PAGER3: A Pathways, Annotated-lists and Gene signatures Electronic Repository Version 3

Query: Neoplasm of the endocrine system

Result Filters

Size of PAGs

Min

Max

Species

Data Source

PAGs related to the disease: 612 PAGs

PAG ID	PAG Type	PAG Name	Size	Pubmed Reference	Organism	Data source	cohension

The M-type PAG-PAG relationships

Network Visualization

PAG_A	PAG_A_SIZE	PAG_B	PAG_B_SIZE	Overlap	Similarity score	LOGCDF

The R-type PAG-PAG relationships

Network Visualization

PAG_A	PAG_B	Total	PAG_A_OUT	PAG_B_IN	A regulate B	LOGCDF

X + S-NED (more detail) 1 NA Homo sapiens

GOA TAX023591 GO:0039692 biological process single stranded viral RNA replication via double stranded DNA intermediate A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via (more detail) 1 NA Homo sapiens

GOA TAX023616 GO:0040032 biological process post embryonic body morphogenesis The process in which the anatomical structures of the post-embryonic soma are generated and organize (more detail) 1 NA Homo sapiens

GOA TAX028876 GO:0070337 molecular function 3' flap structured DNA binding Interacting selectively and non-covalently with a 3'-flap structure in DNA. A DNA flap structure is (more detail) 1 NA Homo sapiens

GOA TAX022741 GO:0035120 biological process post embryonic appendage morphogenesis The process, occurring after embryonic development, by which the anatomical structures of an appenda (more detail) 1 NA Homo sapiens

GOA TAX024966 GO:0045128 biological process negative regulation of reciprocal meiotic recombination Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal (more detail) 1 NA Homo sapiens

GOA TAX027269 GO:0051933 biological process amino acid neurotransmitter reuptake The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactiva (more detail) 1 NA Homo sapiens

GOA TAX033747 GO:1905025 biological process negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization (more detail) 1 NA Homo sapiens

GOA TAX015063 GO:0004333 molecular function fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H(2)O. (more detail) 1 NA Homo sapiens

GOA TAX033751 GO:1905032 biological process negative regulation of membrane repolarization during cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization (more detail) 1 NA Homo sapiens

GOA TAX028084 GO:0060709 biological process glycogen cell differentiation involved in embryonic placenta development The process in which a relatively unspecialized cell acquires specialized features of a glycogen cel (more detail) 1 NA Homo sapiens

GOA TAX034905 GO:2000755 biological process positive regulation of sphingomyelin catabolic process Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic pro (more detail) 1 NA Homo sapiens

GOA MOX011516 Genes associated with Computational Drug Signature CHEMBL591697 Genes associated with Computational Drug Signature CHEMBL591697, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX011582 Genes associated with Computational Drug Signature CHEMBL598789 Genes associated with Computational Drug Signature CHEMBL598789, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX011584 Genes associated with Computational Drug Signature CHEMBL598810 Genes associated with Computational Drug Signature CHEMBL598810, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX011639 Genes associated with Computational Drug Signature CHEMBL610501 Genes associated with Computational Drug Signature CHEMBL610501, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX015976 Genes associated with Computational Drug Signature ZRCCNCSSKWCRDHSRCC Genes associated with Computational Drug Signature ZRCCNCSSKWCRDHSRCC, curated by the Drug Signature (more detail) 1 25990557 Homo sapiens

DSigDB MOX015983 Genes associated with Computational Drug Signature [3 (1H Imidazol 1 ylmethyl)phenyl]methanol Genes associated with Computational Drug Signature [3-(1H-Imidazol-1-ylmethyl)phenyl]methanol, curat (more detail) 1 25990557 Homo sapiens

DSigDB MOX014746 Genes associated with Computational Drug Signature R FADROZOLE Genes associated with Computational Drug Signature R-FADROZOLE, curated by the Drug Signature Databa (more detail) 1 25990557 Homo sapiens

DSigDB MOX014133 Genes associated with Computational Drug Signature NSC 745795 Genes associated with Computational Drug Signature NSC-745795, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX014136 Genes associated with Computational Drug Signature NSC 745798 Genes associated with Computational Drug Signature NSC-745798, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX014138 Genes associated with Computational Drug Signature NSC 745883 Genes associated with Computational Drug Signature NSC-745883, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX017160 Genes associated with Computational Drug Signature Netoglitazone Genes associated with Computational Drug Signature Netoglitazone, curated by the Drug Signature Data (more detail) 1 25990557 Homo sapiens

DSigDB IEI008648 Protein protein interactors of human gene ND4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ND4 (SwissProt ID=A0 (more detail) 1 17535438 Homo sapiens

I2D GEX001289 pendred's syndrome pendred's syndrome associated genes. PAGER constructed this gene set by grouping all genes which are (more detail) 1 NA Homo sapiens

GAD GEX001203 non type 1 diabetes mellitus non-type 1 diabetes mellitus associated genes. PAGER constructed this gene set by grouping all genes (more detail) 1 NA Homo sapiens

GAD GEX001609 tumor progression of bcr/abl negative chronic myeloproliferative disorders tumor progression of bcr/abl negative chronic myeloproliferative disorders associated genes. PAGER c (more detail) 1 NA Homo sapiens

GAD NAX005729 APC (more detail) 1 NA Homo sapiens

Genome Data NAX003051 DAXX (more detail) 1 NA Homo sapiens

Genome Data NAX000644 NRTN (more detail) 1 NA Homo sapiens

Genome Data NAX000165 CLCNKB (more detail) 1 NA Homo sapiens

Genome Data NAX003367 MSH3 (more detail) 1 NA Homo sapiens

Genome Data NAX004701 PRKAR1A (more detail) 1 NA Homo sapiens

Genome Data NAX010311 TERT (more detail) 1 NA Homo sapiens

Genome Data NAX009764 FASLG (more detail) 1 NA Homo sapiens

Genome Data NAX011982 EPCAM (more detail) 1 NA Homo sapiens

Genome Data NAX009402 TG (more detail) 1 NA Homo sapiens

Genome Data NAX010041 CDC73 (more detail) 1 NA Homo sapiens

Genome Data NAX011282 IDH2 (more detail) 1 NA Homo sapiens

Genome Data NAX009324 FOXE1 (more detail) 1 NA Homo sapiens

Genome Data NAX016264 PKD1 (more detail) 1 NA Homo sapiens

Genome Data NAX016268 RASGRP1 (more detail) 1 NA Homo sapiens

Genome Data NAX016345 DNMT3A (more detail) 1 NA Homo sapiens

Genome Data NAX016446 TSC2 (more detail) 1 NA Homo sapiens

Genome Data NAX014537 KEAP1 (more detail) 1 NA Homo sapiens

Genome Data NAX011028 PTEN (more detail) 1 NA Homo sapiens

Genome Data MEX001444 Genes associated with Kinase Inhibitor GW644007X Genes associated with Kinase Inhibitor GW644007X, curated by the Drug Signature Database (DSigDB). (more detail) 1 25990557 Homo sapiens

DSigDB NAX017663 DICER1 (more detail) 1 NA Homo sapiens

Genome Data NAX017841 KCNE3 (more detail) 1 NA Homo sapiens

Genome Data NAX018019 PKD2 (more detail) 1 NA Homo sapiens

Genome Data MEX001624 Genes associated with Kinase Inhibitor CHEMBL519697 Genes associated with Kinase Inhibitor CHEMBL519697, curated by the Drug Signature Database (DSigDB) (more detail) 1 25990557 Homo sapiens

DSigDB MEX001475 Genes associated with Kinase Inhibitor GW441756X Genes associated with Kinase Inhibitor GW441756X, curated by the Drug Signature Database (DSigDB). (more detail) 1 25990557 Homo sapiens

DSigDB MOX003997 Genes associated with Computational Drug Signature DIMETHYLCARBAMODITHIOIC ACID Genes associated with Computational Drug Signature DIMETHYLCARBAMODITHIOIC ACID, curated by the Drug (more detail) 1 25990557 Homo sapiens

DSigDB MOX003587 Genes associated with Computational Drug Signature Dabrafenib Genes associated with Computational Drug Signature Dabrafenib, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX005603 Genes associated with Computational Drug Signature 2,7 Bis(propionamido)anthraquinone Genes associated with Computational Drug Signature 2,7-Bis(propionamido)anthraquinone, curated by th (more detail) 1 25990557 Homo sapiens

DSigDB MOX005604 Genes associated with Computational Drug Signature 2,7 Bis[2 (butylamino)acetamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[2-(butylamino)acetamido]anthraquinone, cu (more detail) 1 25990557 Homo sapiens

DSigDB MOX005383 Genes associated with Computational Drug Signature 1 (6 methoxynaphthalen 2 yl)imidazole Genes associated with Computational Drug Signature 1-(6-methoxynaphthalen-2-yl)imidazole, curated by (more detail) 1 25990557 Homo sapiens

DSigDB MOX005614 Genes associated with Computational Drug Signature 2,7 Bis[3 (butylamino)propionamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[3-(butylamino)propionamido]anthraquinone, (more detail) 1 25990557 Homo sapiens

DSigDB MOX005615 Genes associated with Computational Drug Signature 2,7 Bis[3 (ethylamino)propionamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[3-(ethylamino)propionamido]anthraquinone, (more detail) 1 25990557 Homo sapiens

DSigDB MOX005616 Genes associated with Computational Drug Signature 2,7 Bis[3 (piperazino)propionamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[3-(piperazino)propionamido]anthraquinone, (more detail) 1 25990557 Homo sapiens

DSigDB MOX005618 Genes associated with Computational Drug Signature 2,7 Diaminoanthraquinone Genes associated with Computational Drug Signature 2,7-Diaminoanthraquinone, curated by the Drug Sig (more detail) 1 25990557 Homo sapiens

DSigDB MOX005619 Genes associated with Computational Drug Signature 2,7 Dinitroantraquinone Genes associated with Computational Drug Signature 2,7-Dinitroantraquinone, curated by the Drug Sign (more detail) 1 25990557 Homo sapiens

DSigDB MOX010757 Genes associated with Computational Drug Signature CHEMBL461457 Genes associated with Computational Drug Signature CHEMBL461457, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX010487 Genes associated with Computational Drug Signature CHEMBL431682 Genes associated with Computational Drug Signature CHEMBL431682, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX008201 Genes associated with Computational Drug Signature CHEMBL144757 Genes associated with Computational Drug Signature CHEMBL144757, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX008024 Genes associated with Computational Drug Signature CHEMBL122341 Genes associated with Computational Drug Signature CHEMBL122341, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX008328 Genes associated with Computational Drug Signature CHEMBL179383 Genes associated with Computational Drug Signature CHEMBL179383, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX007539 Genes associated with Computational Drug Signature CCNCSSKWCRAHSRCC Genes associated with Computational Drug Signature CCNCSSKWCRAHSRCC, curated by the Drug Signature D (more detail) 1 25990557 Homo sapiens

DSigDB MOX007540 Genes associated with Computational Drug Signature CCNCSSKWCRDHARCC Genes associated with Computational Drug Signature CCNCSSKWCRDHARCC, curated by the Drug Signature D (more detail) 1 25990557 Homo sapiens

DSigDB MOX007905 Genes associated with Computational Drug Signature CHEMBL115899 Genes associated with Computational Drug Signature CHEMBL115899, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX013476 Genes associated with Computational Drug Signature lividomycin A Genes associated with Computational Drug Signature lividomycin A, curated by the Drug Signature Data (more detail) 1 25990557 Homo sapiens

DSigDB MOX010595 Genes associated with Computational Drug Signature CHEMBL440299 Genes associated with Computational Drug Signature CHEMBL440299, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX010331 Genes associated with Computational Drug Signature CHEMBL413666 Genes associated with Computational Drug Signature CHEMBL413666, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX010955 Genes associated with Computational Drug Signature CHEMBL496013 Genes associated with Computational Drug Signature CHEMBL496013, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX011268 Genes associated with Computational Drug Signature CHEMBL55819 Genes associated with Computational Drug Signature CHEMBL55819, curated by the Drug Signature Databa (more detail) 1 25990557 Homo sapiens

DSigDB MOX010387 Genes associated with Computational Drug Signature CHEMBL418898 Genes associated with Computational Drug Signature CHEMBL418898, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX010993 Genes associated with Computational Drug Signature CHEMBL500664 Genes associated with Computational Drug Signature CHEMBL500664, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX010427 Genes associated with Computational Drug Signature CHEMBL425576 Genes associated with Computational Drug Signature CHEMBL425576, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB TAX029796 GO:0072036 biological process mesenchymal to epithelial transition involved in renal vesicle formation A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular ad (more detail) 1 NA Homo sapiens

GOA TAX029807 GO:0072055 biological process renal cortex development The process whose specific outcome is the progression of the renal cortex over time, from its format (more detail) 1 NA Homo sapiens

GOA TAX030577 GO:0090600 molecular function alpha 1,3 glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues w (more detail) 1 NA Homo sapiens

GOA TAX031072 GO:0098680 molecular function template free RNA nucleotidyltransferase Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition o (more detail) 1 NA Homo sapiens

GOA TAX024329 GO:0043379 biological process memory T cell differentiation The process in which a newly activated T cell acquires specialized features of a memory T cell. (more detail) 1 NA Homo sapiens

GOA TAX029939 GO:0072287 biological process metanephric distal tubule morphogenesis The process in which the anatomical structures of a metanephric distal tubule are generated and orga (more detail) 1 NA Homo sapiens

GOA TAX017477 GO:0009061 biological process anaerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and f (more detail) 1 NA Homo sapiens

GOA TAX018397 GO:0014853 biological process regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of (more detail) 1 NA Homo sapiens

GOA TAX019339 GO:0017020 molecular function myosin phosphatase regulator activity Modulation of the activity of the enzyme myosin phosphatase. (more detail) 1 NA Homo sapiens

GOA TAX025048 GO:0045282 cellular component plasma membrane succinate dehydrogenase complex A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur pr (more detail) 1 NA Homo sapiens

GOA TAX025638 GO:0046554 molecular function malate dehydrogenase (NADP+) activity Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. (more detail) 1 NA Homo sapiens

GOA TAX026904 GO:0051257 biological process meiotic spindle midzone assembly The formation of the spindle midzone, the area in the center of the spindle where the spindle microt (more detail) 1 NA Homo sapiens

GOA TAX026156 GO:0048352 biological process paraxial mesoderm structural organization The process that contributes to the act of creating the structural organization of the paraxial meso (more detail) 1 NA Homo sapiens

GOA TAX033207 GO:1903925 biological process response to bisphenol A Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 1 NA Homo sapiens

GOA TAX033208 GO:1903926 biological process cellular response to bisphenol A Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 1 NA Homo sapiens

GOA TAX032174 GO:1901580 biological process regulation of telomeric RNA transcription from RNA pol II promoter Any process that modulates the frequency, rate or extent of telomeric RNA transcription from RNA pol (more detail) 1 NA Homo sapiens

GOA TAX033047 GO:1903618 biological process regulation of transdifferentiation Any process that modulates the frequency, rate or extent of transdifferentiation. (more detail) 1 NA Homo sapiens

GOA TAX033441 GO:1904414 biological process positive regulation of cardiac ventricle development Any process that activates or increases the frequency, rate or extent of cardiac ventricle developme (more detail) 1 NA Homo sapiens

GOA TAX033812 GO:1905176 biological process positive regulation of vascular smooth muscle cell dedifferentiation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell (more detail) 1 NA Homo sapiens

GOA TAX015884 GO:0005715 cellular component late recombination nodule An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis (more detail) 1 NA Homo sapiens

GOA TAX031855 GO:1900163 biological process positive regulation of phospholipid scramblase activity Any process that activates or increases the frequency, rate or extent of phospholipid scramblase act (more detail) 1 NA Homo sapiens

GOA TAX033875 GO:1905316 biological process superior endocardial cushion morphogenesis The developmental process by which a superior endocardial cushion is generated and organized. (more detail) 1 NA Homo sapiens

GOA TAX028437 GO:0061444 biological process endocardial cushion cell development The process whose specific outcome is the progression of an endocardial cushion cell over time, from (more detail) 1 NA Homo sapiens

GOA MOX012400 Genes associated with Computational Drug Signature DNC012429 Genes associated with Computational Drug Signature DNC012429, curated by the Drug Signature Database (more detail) 1 25990557 Homo sapiens

DSigDB MOX012402 Genes associated with Computational Drug Signature DNC012448 Genes associated with Computational Drug Signature DNC012448, curated by the Drug Signature Database (more detail) 1 25990557 Homo sapiens

DSigDB MOX012403 Genes associated with Computational Drug Signature DNC012452 Genes associated with Computational Drug Signature DNC012452, curated by the Drug Signature Database (more detail) 1 25990557 Homo sapiens

DSigDB MOX012157 Genes associated with Computational Drug Signature Dabrafenib Genes associated with Computational Drug Signature Dabrafenib, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX011563 Genes associated with Computational Drug Signature CHEMBL597101 Genes associated with Computational Drug Signature CHEMBL597101, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX012561 Genes associated with Computational Drug Signature Erismodegib Genes associated with Computational Drug Signature Erismodegib, curated by the Drug Signature Databa (more detail) 1 25990557 Homo sapiens

DSigDB MOX011632 Genes associated with Computational Drug Signature CHEMBL608437 Genes associated with Computational Drug Signature CHEMBL608437, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX015391 Genes associated with Computational Drug Signature T6387866 Genes associated with Computational Drug Signature T6387866, curated by the Drug Signature Database (more detail) 1 25990557 Homo sapiens

DSigDB MOX015718 Genes associated with Computational Drug Signature UNII 5YL4IQ1078 Genes associated with Computational Drug Signature UNII-5YL4IQ1078, curated by the Drug Signature Da (more detail) 1 25990557 Homo sapiens

DSigDB MOX014137 Genes associated with Computational Drug Signature NSC 745799 Genes associated with Computational Drug Signature NSC-745799, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB IEI004270 Protein protein interactors of human gene ERICH3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ERICH3 (SwissProt ID (more detail) 1 17535438 Homo sapiens