PAGER3: A Pathways, Annotated-lists and Gene signatures Electronic Repository Version 3

Query: Melanoma

Result Filters

Size of PAGs

Min

Max

Species

Data Source

PAGs related to the disease: 430 PAGs

PAG ID	PAG Type	PAG Name	Size	Pubmed Reference	Organism	Data source	cohension

The M-type PAG-PAG relationships

Network Visualization

PAG_A	PAG_A_SIZE	PAG_B	PAG_B_SIZE	Overlap	Similarity score	LOGCDF

The R-type PAG-PAG relationships

Network Visualization

PAG_A	PAG_B	Total	PAG_A_OUT	PAG_B_IN	A regulate B	LOGCDF

X + S-NED (more detail) 1 NA Homo sapiens

GOA TAX027979 GO:0060542 biological process regulation of strand invasion Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the (more detail) 1 NA Homo sapiens

GOA TAX024573 GO:0044029 biological process hypomethylation of CpG island An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. (more detail) 1 NA Homo sapiens

GOA TAX020583 GO:0030616 molecular function transforming growth factor beta receptor, common partner cytoplasmic mediator activity A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator (more detail) 1 NA Homo sapiens

GOA TAX033944 GO:1905464 biological process positive regulation of DNA duplex unwinding Any process that activates or increases the frequency, rate or extent of DNA duplex unwinding. (more detail) 1 NA Homo sapiens

GOA TAX033207 GO:1903925 biological process response to bisphenol A Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 1 NA Homo sapiens

GOA TAX033208 GO:1903926 biological process cellular response to bisphenol A Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 1 NA Homo sapiens

GOA TAX014659 GO:0003251 biological process positive regulation of cell proliferation involved in heart valve morphogenesis Any process that increases the rate, frequency or extent of cell proliferation that contributes to t (more detail) 1 NA Homo sapiens

GOA TAX027868 GO:0060383 biological process positive regulation of DNA strand elongation Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elonga (more detail) 1 NA Homo sapiens

GOA MOX011827 Genes associated with Computational Drug Signature CHEMBL89250 Genes associated with Computational Drug Signature CHEMBL89250, curated by the Drug Signature Databa (more detail) 1 25990557 Homo sapiens

DSigDB MOX012161 Genes associated with Computational Drug Signature Daedalin A Genes associated with Computational Drug Signature Daedalin A, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX015777 Genes associated with Computational Drug Signature UNII ZN90E4027M Genes associated with Computational Drug Signature UNII-ZN90E4027M, curated by the Drug Signature Da (more detail) 1 25990557 Homo sapiens

DSigDB MOX015264 Genes associated with Computational Drug Signature SureCN12261351 Genes associated with Computational Drug Signature SureCN12261351, curated by the Drug Signature Dat (more detail) 1 25990557 Homo sapiens

DSigDB MOX014134 Genes associated with Computational Drug Signature NSC 745796 Genes associated with Computational Drug Signature NSC-745796, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB IEI009449 Protein protein interactors of human gene PAGE5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PAGE5 (SwissProt ID= (more detail) 1 17535438 Homo sapiens

I2D IEI009771 Protein protein interactors of human gene PEX5L from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PEX5L (SwissProt ID= (more detail) 1 17535438 Homo sapiens

I2D IEI003599 Protein protein interactors of human gene DLX1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DLX1 (SwissProt ID=P (more detail) 1 17535438 Homo sapiens

I2D IEI005677 Protein protein interactors of human gene H2BW2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene H2BW2 (SwissProt ID= (more detail) 1 17535438 Homo sapiens

I2D IEI000278 Protein protein interactors of human gene ADGRF3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ADGRF3 (SwissProt ID (more detail) 1 17535438 Homo sapiens

I2D NAX004660 ERCC4 (more detail) 1 NA Homo sapiens

Genome Data NAX014453 TYR (more detail) 1 NA Homo sapiens

Genome Data NAX011830 DDB2 (more detail) 1 NA Homo sapiens

Genome Data NAX014049 CTSC (more detail) 1 NA Homo sapiens

Genome Data NAX010115 POT1 (more detail) 1 NA Homo sapiens

Genome Data NAX013161 ERCC6 (more detail) 1 NA Homo sapiens

Genome Data MEX001493 Genes associated with Kinase Inhibitor Chk2 Inhibitor II Genes associated with Kinase Inhibitor Chk2 Inhibitor II, curated by the Drug Signature Database (DS (more detail) 1 25990557 Homo sapiens

DSigDB MEX003684 Genes associated with Perturbagen Signature nalidixic acid Genes associated with Perturbagen Signature nalidixic acid, curated by the Drug Signature Database ( (more detail) 1 25990557 Homo sapiens

DSigDB MOX003587 Genes associated with Computational Drug Signature Dabrafenib Genes associated with Computational Drug Signature Dabrafenib, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX003881 Genes associated with Computational Drug Signature Coke Genes associated with Computational Drug Signature Coke, curated by the Drug Signature Database (DSi (more detail) 1 25990557 Homo sapiens

DSigDB MOX000021 Genes associated with Computational Drug Signature Dihydrocaffeic acid Genes associated with Computational Drug Signature Dihydrocaffeic acid, curated by the Drug Signatur (more detail) 1 25990557 Homo sapiens

DSigDB MOX005737 Genes associated with Computational Drug Signature 2 methyl 3H naphtho[3,2 e]benzimidazole 6,11 dione Genes associated with Computational Drug Signature 2-methyl-3H-naphtho[3,2-e]benzimidazole-6,11-dion (more detail) 1 25990557 Homo sapiens

DSigDB MOX005596 Genes associated with Computational Drug Signature 2,7 Bis(butyramido)anthraquinone Genes associated with Computational Drug Signature 2,7-Bis(butyramido)anthraquinone, curated by the (more detail) 1 25990557 Homo sapiens

DSigDB MOX005592 Genes associated with Computational Drug Signature 2,7 Bis(3 chloropropionamido)anthraquinone Genes associated with Computational Drug Signature 2,7-Bis(3-chloropropionamido)anthraquinone, curat (more detail) 1 25990557 Homo sapiens

DSigDB MOX005415 Genes associated with Computational Drug Signature 1 Ethylidenethiosemicarbazide Genes associated with Computational Drug Signature 1-Ethylidenethiosemicarbazide, curated by the Dru (more detail) 1 25990557 Homo sapiens

DSigDB MOX005421 Genes associated with Computational Drug Signature 1 hydroxy 3 (4 nitrophenyl)urea Genes associated with Computational Drug Signature 1-hydroxy-3-(4-nitrophenyl)urea, curated by the D (more detail) 1 25990557 Homo sapiens

DSigDB MOX005612 Genes associated with Computational Drug Signature 2,7 Bis[2 (propylamino)acetamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[2-(propylamino)acetamido]anthraquinone, c (more detail) 1 25990557 Homo sapiens

DSigDB MOX002945 Genes associated with Computational Drug Signature Benzeneseleninic acid Genes associated with Computational Drug Signature Benzeneseleninic acid, curated by the Drug Signat (more detail) 1 25990557 Homo sapiens

DSigDB MOX006823 Genes associated with Computational Drug Signature AGN PC 0BMIYW Genes associated with Computational Drug Signature AGN-PC-0BMIYW, curated by the Drug Signature Data (more detail) 1 25990557 Homo sapiens

DSigDB MOX011047 Genes associated with Computational Drug Signature CHEMBL505588 Genes associated with Computational Drug Signature CHEMBL505588, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX010797 Genes associated with Computational Drug Signature CHEMBL467890 Genes associated with Computational Drug Signature CHEMBL467890, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX010550 Genes associated with Computational Drug Signature CHEMBL437510 Genes associated with Computational Drug Signature CHEMBL437510, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX008101 Genes associated with Computational Drug Signature CHEMBL1269426 Genes associated with Computational Drug Signature CHEMBL1269426, curated by the Drug Signature Data (more detail) 1 25990557 Homo sapiens

DSigDB MOX008201 Genes associated with Computational Drug Signature CHEMBL144757 Genes associated with Computational Drug Signature CHEMBL144757, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX008872 Genes associated with Computational Drug Signature CHEMBL219339 Genes associated with Computational Drug Signature CHEMBL219339, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX008902 Genes associated with Computational Drug Signature CHEMBL221291 Genes associated with Computational Drug Signature CHEMBL221291, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX009110 Genes associated with Computational Drug Signature CHEMBL244248 Genes associated with Computational Drug Signature CHEMBL244248, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX009142 Genes associated with Computational Drug Signature CHEMBL246622 Genes associated with Computational Drug Signature CHEMBL246622, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX009852 Genes associated with Computational Drug Signature CHEMBL374108 Genes associated with Computational Drug Signature CHEMBL374108, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX013267 Genes associated with Computational Drug Signature KAZINOL S Genes associated with Computational Drug Signature KAZINOL S, curated by the Drug Signature Database (more detail) 1 25990557 Homo sapiens

DSigDB MOX009875 Genes associated with Computational Drug Signature CHEMBL375991 Genes associated with Computational Drug Signature CHEMBL375991, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX009881 Genes associated with Computational Drug Signature CHEMBL376219 Genes associated with Computational Drug Signature CHEMBL376219, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB TAX015705 GO:0005302 molecular function L tyrosine transmembrane transporter activity Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3 (more detail) 1 NA Homo sapiens

GOA TAX016768 GO:0007066 biological process female meiosis sister chromatid cohesion The joining of the sister chromatids of a replicated chromosome along the entire length of the chrom (more detail) 1 NA Homo sapiens

GOA TAX024572 GO:0044028 biological process DNA hypomethylation An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA. (more detail) 1 NA Homo sapiens

GOA TAX033048 GO:1903620 biological process positive regulation of transdifferentiation Any process that activates or increases the frequency, rate or extent of transdifferentiation. (more detail) 1 NA Homo sapiens

GOA TAX033436 GO:1904404 biological process response to formaldehyde Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 1 NA Homo sapiens

GOA TAX028084 GO:0060709 biological process glycogen cell differentiation involved in embryonic placenta development The process in which a relatively unspecialized cell acquires specialized features of a glycogen cel (more detail) 1 NA Homo sapiens

GOA MOX017324 Genes associated with Computational Drug Signature MI 63 Genes associated with Computational Drug Signature MI-63, curated by the Drug Signature Database (DS (more detail) 1 25990557 Homo sapiens

DSigDB MOX012157 Genes associated with Computational Drug Signature Dabrafenib Genes associated with Computational Drug Signature Dabrafenib, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX012271 Genes associated with Computational Drug Signature Diarylurea deriv. 15 Genes associated with Computational Drug Signature Diarylurea deriv. 15, curated by the Drug Signatu (more detail) 1 25990557 Homo sapiens

DSigDB MOX014133 Genes associated with Computational Drug Signature NSC 745795 Genes associated with Computational Drug Signature NSC-745795, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX014140 Genes associated with Computational Drug Signature NSC 745886 Genes associated with Computational Drug Signature NSC-745886, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX014145 Genes associated with Computational Drug Signature NSC 87877 Genes associated with Computational Drug Signature NSC-87877, curated by the Drug Signature Database (more detail) 1 25990557 Homo sapiens

DSigDB MOX014813 Genes associated with Computational Drug Signature RG 7112 Genes associated with Computational Drug Signature RG-7112, curated by the Drug Signature Database ( (more detail) 1 25990557 Homo sapiens

DSigDB IEI010941 Protein protein interactors of human gene RAD51AP2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RAD51AP2 (SwissProt (more detail) 1 17535438 Homo sapiens

I2D IEI001608 Protein protein interactors of human gene C2orf74 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene C2orf74 (SwissProt I (more detail) 1 17535438 Homo sapiens

I2D NAX000043 ERCC5 (more detail) 1 NA Homo sapiens

Genome Data NAX006401 PALLD (more detail) 1 NA Homo sapiens

Genome Data NAX005109 PIK3CA (more detail) 1 NA Homo sapiens

Genome Data NAX010485 BRAF (more detail) 1 NA Homo sapiens

Genome Data NAX009747 CXCR4 (more detail) 1 NA Homo sapiens

Genome Data NAX016335 CDKN2B (more detail) 1 NA Homo sapiens

Genome Data MEX002243 Genes associated with Kinase Inhibitor SB 682330 A Genes associated with Kinase Inhibitor SB-682330-A, curated by the Drug Signature Database (DSigDB). (more detail) 1 25990557 Homo sapiens

DSigDB MOX000750 Genes associated with Computational Drug Signature Dabequin Genes associated with Computational Drug Signature Dabequin, curated by the Drug Signature Database (more detail) 1 25990557 Homo sapiens

DSigDB MOX001526 Genes associated with Computational Drug Signature 2 AMINO 4,6 DINITROTOLUENE Genes associated with Computational Drug Signature 2-AMINO-4,6-DINITROTOLUENE, curated by the Drug S (more detail) 1 25990557 Homo sapiens

DSigDB MOX000108 Genes associated with Computational Drug Signature 9 Acridinethiol Genes associated with Computational Drug Signature 9-Acridinethiol, curated by the Drug Signature Da (more detail) 1 25990557 Homo sapiens

DSigDB MOX006010 Genes associated with Computational Drug Signature 4 adamantyl resorcinol Genes associated with Computational Drug Signature 4-adamantyl resorcinol, curated by the Drug Signa (more detail) 1 25990557 Homo sapiens

DSigDB MOX005605 Genes associated with Computational Drug Signature 2,7 Bis[2 (diethylamino)acetamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[2-(diethylamino)acetamido]anthraquinone, (more detail) 1 25990557 Homo sapiens

DSigDB MOX004822 Genes associated with Computational Drug Signature uracil Genes associated with Computational Drug Signature uracil, curated by the Drug Signature Database (D (more detail) 1 25990557 Homo sapiens

DSigDB MOX005845 Genes associated with Computational Drug Signature 3 (5 Mercapto [1,3,4]oxadiazol 2 yl) phenol Genes associated with Computational Drug Signature 3-(5-Mercapto-[1,3,4]oxadiazol-2-yl)-phenol, cura (more detail) 1 25990557 Homo sapiens

DSigDB MOX005613 Genes associated with Computational Drug Signature 2,7 Bis[2 (pyrrolidino)acetamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[2-(pyrrolidino)acetamido]anthraquinone, c (more detail) 1 25990557 Homo sapiens

DSigDB MOX006185 Genes associated with Computational Drug Signature 5 benzyl 1,3,4 oxadiazole 2 thiol Genes associated with Computational Drug Signature 5-benzyl-1,3,4-oxadiazole-2-thiol, curated by the (more detail) 1 25990557 Homo sapiens

DSigDB MOX005956 Genes associated with Computational Drug Signature 4,4' Dihydroxychalcone Genes associated with Computational Drug Signature 4,4'-Dihydroxychalcone, curated by the Drug Signa (more detail) 1 25990557 Homo sapiens

DSigDB MOX006235 Genes associated with Computational Drug Signature 5 Phenyl 1,3,4 thiadiazole 2 thiol Genes associated with Computational Drug Signature 5-Phenyl-1,3,4-thiadiazole-2-thiol, curated by th (more detail) 1 25990557 Homo sapiens

DSigDB MOX007759 Genes associated with Computational Drug Signature CHEMBL1087578 Genes associated with Computational Drug Signature CHEMBL1087578, curated by the Drug Signature Data (more detail) 1 25990557 Homo sapiens

DSigDB MOX010750 Genes associated with Computational Drug Signature CHEMBL459604 Genes associated with Computational Drug Signature CHEMBL459604, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX011367 Genes associated with Computational Drug Signature CHEMBL569315 Genes associated with Computational Drug Signature CHEMBL569315, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX008677 Genes associated with Computational Drug Signature CHEMBL206902 Genes associated with Computational Drug Signature CHEMBL206902, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX008682 Genes associated with Computational Drug Signature CHEMBL207146 Genes associated with Computational Drug Signature CHEMBL207146, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX007919 Genes associated with Computational Drug Signature CHEMBL1163927 Genes associated with Computational Drug Signature CHEMBL1163927, curated by the Drug Signature Data (more detail) 1 25990557 Homo sapiens

DSigDB MOX009138 Genes associated with Computational Drug Signature CHEMBL246045 Genes associated with Computational Drug Signature CHEMBL246045, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX009858 Genes associated with Computational Drug Signature CHEMBL374862 Genes associated with Computational Drug Signature CHEMBL374862, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX010656 Genes associated with Computational Drug Signature CHEMBL446756 Genes associated with Computational Drug Signature CHEMBL446756, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX009272 Genes associated with Computational Drug Signature CHEMBL262340 Genes associated with Computational Drug Signature CHEMBL262340, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB TAX029374 GO:0071301 biological process cellular response to vitamin B1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 1 NA Homo sapiens

GOA TAX018056 GO:0010705 biological process meiotic DNA double strand break processing involved in reciprocal meiotic recombination The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the (more detail) 1 NA Homo sapiens

GOA TAX025044 GO:0045273 cellular component respiratory chain complex II A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase (more detail) 1 NA Homo sapiens

GOA TAX014842 GO:0003908 molecular function methylated DNA [protein] cysteine S methyltransferase activity Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without (more detail) 1 NA Homo sapiens

GOA TAX034288 GO:1990572 cellular component TERT RMRP complex A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of (more detail) 1 NA Homo sapiens

GOA TAX034408 GO:1990955 molecular function G rich single stranded DNA binding Interacting selectively and non-covalently with G-rich, single-stranded DNA. (more detail) 1 NA Homo sapiens

GOA TAX015181 GO:0004503 molecular function monophenol monooxygenase activity Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O. (more detail) 1 NA Homo sapiens

GOA TAX033869 GO:1905305 biological process negative regulation of cardiac myofibril assembly Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assem (more detail) 1 NA Homo sapiens

GOA TAX034940 GO:2000808 biological process negative regulation of synaptic vesicle clustering Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle cluste (more detail) 1 NA Homo sapiens

GOA TAX028464 GO:0061519 biological process macrophage homeostasis The process of regulating the proliferation and elimination of macrophage cells such that the total (more detail) 1 NA Homo sapiens

GOA MOX011551 Genes associated with Computational Drug Signature CHEMBL595241 Genes associated with Computational Drug Signature CHEMBL595241, curated by the Drug Signature Datab (more detail) 1 25990557 Homo sapiens

DSigDB MOX012270 Genes associated with Computational Drug Signature Diarylurea deriv. 14a Genes associated with Computational Drug Signature Diarylurea deriv. 14a, curated by the Drug Signat (more detail) 1 25990557 Homo sapiens

DSigDB MOX015175 Genes associated with Computational Drug Signature SRI 224 Genes associated with Computational Drug Signature SRI-224, curated by the Drug Signature Database ( (more detail) 1 25990557 Homo sapiens

DSigDB MOX014128 Genes associated with Computational Drug Signature NSC 66811 Genes associated with Computational Drug Signature NSC-66811, curated by the Drug Signature Database (more detail) 1 25990557 Homo sapiens

DSigDB MOX014137 Genes associated with Computational Drug Signature NSC 745799 Genes associated with Computational Drug Signature NSC-745799, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX014138 Genes associated with Computational Drug Signature NSC 745883 Genes associated with Computational Drug Signature NSC-745883, curated by the Drug Signature Databas (more detail) 1 25990557 Homo sapiens

DSigDB MOX013976 Genes associated with Computational Drug Signature Naphtho[2,3 f]quinoxaline 7,12 dione, 2,3 dimethyl Genes associated with Computational Drug Signature Naphtho[2,3-f]quinoxaline-7,12-dione, 2,3-dimethy (more detail) 1 25990557 Homo sapiens

DSigDB IEI005448 Protein protein interactors of human gene GPR52 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GPR52 (SwissProt ID= (more detail) 1 17535438 Homo sapiens