Y-U
(more detail)
439 NA Homo sapiens
TAX019204
GO:0016772 molecular function transferase activity, transferring phosphorus containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acc (more detail) 1015 NA Homo sapiens
TAX029048
GO:0070647 biological process protein modification by small protein conjugation or removal A protein modification process in which one or more groups of a small protein, such as ubiquitin or (more detail) 921 NA Homo sapiens
TAX019217
GO:0016787 molecular function hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. H (more detail) 2610 NA Homo sapiens
TAX018971
GO:0016310 biological process phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosph (more detail) 1124 NA Homo sapiens
TAX019482
GO:0018193 biological process peptidyl amino acid modification The alteration of an amino acid residue in a peptide. (more detail) 844 NA Homo sapiens
TAX016600
GO:0006796 biological process phosphate containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphor (more detail) 1970 NA Homo sapiens
TAX016599
GO:0006793 biological process phosphorus metabolic process The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that c (more detail) 1990 NA Homo sapiens
FEX000742
Breast Speers09 780genes Supplementary table 1- All kinases used in expression profiling (more detail) 745 19808870 Homo sapiens
TAX021555
GO:0032446 biological process protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or (more detail) 671 NA Homo sapiens
FEX002708
Manning02 624genes ProteinKinases protein kinases : The protein kinase complement of the human genome (more detail) 363 12471243 Homo sapiens
TAX019094
GO:0016567 biological process protein ubiquitination The process in which one or more ubiquitin groups are added to a protein. (more detail) 621 NA Homo sapiens
TAX000096
Genes annotated by the GO term GO:0044267. The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. (more detail) 1080 NA Homo sapiens
TAX000089
Genes annotated by the GO term GO:0044260. The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, as carried out by individual cells. (more detail) 1094 NA Homo sapiens
MEX002069
Genes associated with Kinase Inhibitor staurosporine Genes associated with Kinase Inhibitor staurosporine, curated by the Drug Signature Database (DSigDB (more detail) 313 25990557 Homo sapiens
TAX000555
Genes annotated by the GO term GO:0019538. The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. (more detail) 1187 NA Homo sapiens
TAX000557
Genes annotated by the GO term GO:0006464. The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co translational, post translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre translation modification). (more detail) 615 NA Homo sapiens
TAX017144
GO:0008236 molecular function serine type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that in (more detail) 281 NA Homo sapiens
TAX000530
Genes annotated by the GO term GO:0043687. The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. (more detail) 462 NA Homo sapiens
TAX000053
Genes annotated by the GO term GO:0043412. The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties. (more detail) 634 NA Homo sapiens
TAX019423
GO:0017171 molecular function serine hydrolase activity Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad (more detail) 286 NA Homo sapiens
MEX002285
Genes associated with Kinase Inhibitor Lestaurtinib Genes associated with Kinase Inhibitor Lestaurtinib, curated by the Drug Signature Database (DSigDB) (more detail) 270 25990557 Homo sapiens
TAX001329
Genes annotated by the GO term GO:0004672. Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. (more detail) 281 NA Homo sapiens
TAX015037
GO:0004252 molecular function serine type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic m (more detail) 251 NA Homo sapiens
MEX000996
Genes associated with Approved Drug sunitinib Genes associated with Approved Drug sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 256 25990557 Homo sapiens
TAX015788
GO:0005524 molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally import (more detail) 1460 NA Homo sapiens
MEX001673
Genes associated with Kinase Inhibitor SureCN1564574 Genes associated with Kinase Inhibitor SureCN1564574, curated by the Drug Signature Database (DSigDB (more detail) 254 25990557 Homo sapiens
TAX017088
GO:0008144 molecular function drug binding Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substan (more detail) 1709 NA Homo sapiens
TAX021636
GO:0032559 molecular function adenyl ribonucleotide binding Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of (more detail) 1510 NA Homo sapiens
TAX028530
GO:0061659 molecular function ubiquitin like protein ligase activity Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction (more detail) 236 NA Homo sapiens
TAX020566
GO:0030554 molecular function adenyl nucleotide binding Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adeno (more detail) 1520 NA Homo sapiens
TAX028518
GO:0061630 molecular function ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X (more detail) 231 NA Homo sapiens
TAX027094
GO:0051603 biological process proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pat (more detail) 526 NA Homo sapiens
MEX001467
Genes associated with Kinase Inhibitor OTSSP167 Genes associated with Kinase Inhibitor OTSSP167, curated by the Drug Signature Database (DSigDB). (more detail) 234 25990557 Homo sapiens
TAX001314
Genes annotated by the GO term GO:0016773. Catalysis of the transfer of a phosphorus containing group from one compound (donor) to an alcohol group (acceptor). (more detail) 329 NA Homo sapiens
TAX001221
Genes annotated by the GO term GO:0016301. Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. (more detail) 364 NA Homo sapiens
TAX026893
GO:0051246 biological process regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 2724 NA Homo sapiens
TAX023000
GO:0035639 molecular function purine ribonucleoside triphosphate binding Interacting selectively and non-covalently with a purine ribonucleoside triphosphate, a compound con (more detail) 1788 NA Homo sapiens
MEX001791
Genes associated with Kinase Inhibitor NVP TAE684 Genes associated with Kinase Inhibitor NVP-TAE684, curated by the Drug Signature Database (DSigDB). (more detail) 210 25990557 Homo sapiens
TAX017142
GO:0008234 molecular function cysteine type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulf (more detail) 200 NA Homo sapiens
MEX001224
Genes associated with Kinase Inhibitor NVP TAE684 Genes associated with Kinase Inhibitor NVP-TAE684, curated by the Drug Signature Database (DSigDB). (more detail) 203 25990557 Homo sapiens
MEX001653
Genes associated with Kinase Inhibitor staurosporine Genes associated with Kinase Inhibitor staurosporine, curated by the Drug Signature Database (DSigDB (more detail) 195 25990557 Homo sapiens
MEX001635
Genes associated with Kinase Inhibitor BX 912 Genes associated with Kinase Inhibitor BX-912, curated by the Drug Signature Database (DSigDB). (more detail) 203 25990557 Homo sapiens
TAX021632
GO:0032555 molecular function purine ribonucleotide binding Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of (more detail) 1845 NA Homo sapiens
MEX001777
Genes associated with Kinase Inhibitor HG 14 10 04 Genes associated with Kinase Inhibitor HG-14-10-04, curated by the Drug Signature Database (DSigDB). (more detail) 202 25990557 Homo sapiens
TAX013304
GO:0000209 biological process protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. (more detail) 237 NA Homo sapiens
MEX000995
Genes associated with Approved Drug bosutinib Genes associated with Approved Drug bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 199 25990557 Homo sapiens
TAX030822
GO:0097367 molecular function carbohydrate derivative binding Interacting selectively and non-covalently with a carbohydrate derivative. (more detail) 2148 NA Homo sapiens
MEX001522
Genes associated with Kinase Inhibitor 841290 80 0 Genes associated with Kinase Inhibitor 841290-80-0, curated by the Drug Signature Database (DSigDB). (more detail) 201 25990557 Homo sapiens
TAX019366
GO:0017076 molecular function purine nucleotide binding Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a pur (more detail) 1856 NA Homo sapiens
TAX021630
GO:0032553 molecular function ribonucleotide binding Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribon (more detail) 1860 NA Homo sapiens
TAX001337
Genes annotated by the GO term GO:0004674. Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. (more detail) 202 NA Homo sapiens
TAX025737
GO:0046777 biological process protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylat (more detail) 198 NA Homo sapiens
TAX015343
GO:0004721 molecular function phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kin (more detail) 187 NA Homo sapiens
MEX002024
Genes associated with Kinase Inhibitor 841290 80 0 Genes associated with Kinase Inhibitor 841290-80-0, curated by the Drug Signature Database (DSigDB). (more detail) 192 25990557 Homo sapiens
TAX019889
GO:0019941 biological process modification dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 454 NA Homo sapiens
IEI006058
Protein protein interactors of human gene HSP90AA1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene HSP90AA1 (SwissProt (more detail) 831 17535438 Homo sapiens
TAX017145
GO:0008237 molecular function metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, on (more detail) 185 NA Homo sapiens
TAX001431
Genes annotated by the GO term GO:0016772. Catalysis of the transfer of a phosphorus containing group from one compound (donor) to another (acceptor). (more detail) 419 NA Homo sapiens
TAX016382
GO:0006511 biological process ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 448 NA Homo sapiens
TAX024488
GO:0043632 biological process modification dependent macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by cova (more detail) 464 NA Homo sapiens
MEX002397
Genes associated with Kinase Inhibitor Sunitinib Genes associated with Kinase Inhibitor Sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 185 25990557 Homo sapiens
TAX015338
GO:0004713 molecular function protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. (more detail) 181 NA Homo sapiens
IEI006060
Protein protein interactors of human gene HSP90AB1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene HSP90AB1 (SwissProt (more detail) 703 17535438 Homo sapiens
TAX032073
GO:1901265 molecular function nucleoside phosphate binding Interacting selectively and non-covalently with nucleoside phosphate. (more detail) 2092 NA Homo sapiens
MEX002276
Genes associated with Kinase Inhibitor Sunitinib Genes associated with Kinase Inhibitor Sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 183 25990557 Homo sapiens
TAX013287
GO:0000166 molecular function nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleosid (more detail) 2091 NA Homo sapiens
MEX001215
Genes associated with Kinase Inhibitor KW 2449 Genes associated with Kinase Inhibitor KW-2449, curated by the Drug Signature Database (DSigDB). (more detail) 182 25990557 Homo sapiens
TAX000540
Genes annotated by the GO term GO:0006468. The process of introducing a phosphate group on to a protein. (more detail) 270 NA Homo sapiens
TAX016353
GO:0006470 biological process protein dephosphorylation The process of removing one or more phosphoric residues from a protein. (more detail) 203 NA Homo sapiens
TAX000469
Genes annotated by the GO term GO:0016310. The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. (more detail) 303 NA Homo sapiens
PEX001788
Pkinase: Protein kinase domain (more detail) 165 NA Homo sapiens
TAX000052
Genes annotated by the GO term GO:0043283. The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. (more detail) 1637 NA Homo sapiens
TAX026231
GO:0048583 biological process regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to st (more detail) 4003 NA Homo sapiens
TAX019498
GO:0018212 biological process peptidyl tyrosine modification The modification of peptidyl-tyrosine. (more detail) 193 NA Homo sapiens
TAX023252
GO:0036094 molecular function small molecule binding Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeri (more detail) 2457 NA Homo sapiens
TAX024195
GO:0043168 molecular function anion binding Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net (more detail) 2688 NA Homo sapiens
TAX021421
GO:0032268 biological process regulation of cellular protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 2479 NA Homo sapiens
TAX019463
GO:0018108 biological process peptidyl tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. (more detail) 190 NA Homo sapiens
TAX001296
Genes annotated by the GO term GO:0008233. Catalysis of the hydrolysis of peptide bonds. (more detail) 169 NA Homo sapiens
TAX025777
GO:0046872 molecular function metal ion binding Interacting selectively and non-covalently with any metal ion. (more detail) 4109 NA Homo sapiens
MEX002417
Genes associated with Kinase Inhibitor Nintedanib Genes associated with Kinase Inhibitor Nintedanib, curated by the Drug Signature Database (DSigDB). (more detail) 158 25990557 Homo sapiens
MEX002280
Genes associated with Kinase Inhibitor Vargatef Genes associated with Kinase Inhibitor Vargatef, curated by the Drug Signature Database (DSigDB). (more detail) 158 25990557 Homo sapiens
TAX034193
GO:1990234 cellular component transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group (more detail) 724 NA Homo sapiens
TAX024196
GO:0043169 molecular function cation binding Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net (more detail) 4200 NA Homo sapiens
TAX020967
GO:0031399 biological process regulation of protein modification process Any process that modulates the frequency, rate or extent of the covalent alteration of one or more a (more detail) 1744 NA Homo sapiens
TAX032530
GO:1902494 cellular component catalytic complex A protein complex which is capable of catalytic activity. (more detail) 1315 NA Homo sapiens
MEX001768
Genes associated with Kinase Inhibitor HG 9 91 01 Genes associated with Kinase Inhibitor HG-9-91-01, curated by the Drug Signature Database (DSigDB). (more detail) 150 25990557 Homo sapiens
MEX001293
Genes associated with Kinase Inhibitor AST 487 Genes associated with Kinase Inhibitor AST 487, curated by the Drug Signature Database (DSigDB). (more detail) 147 25990557 Homo sapiens
MEX002012
Genes associated with Kinase Inhibitor Foretinib Genes associated with Kinase Inhibitor Foretinib, curated by the Drug Signature Database (DSigDB). (more detail) 149 25990557 Homo sapiens
MEX001450
Genes associated with Kinase Inhibitor 602306 29 6 Genes associated with Kinase Inhibitor 602306-29-6, curated by the Drug Signature Database (DSigDB). (more detail) 154 25990557 Homo sapiens
TAX019460
GO:0018105 biological process peptidyl serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. (more detail) 175 NA Homo sapiens
TAX019495
GO:0018209 biological process peptidyl serine modification The modification of peptidyl-serine. (more detail) 194 NA Homo sapiens
TAX017473
GO:0009057 biological process macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of h (more detail) 907 NA Homo sapiens
MEX001115
Genes associated with Approved Drug crizotinib Genes associated with Approved Drug crizotinib, curated by the Drug Signature Database (DSigDB). (more detail) 146 25990557 Homo sapiens
MEX001676
Genes associated with Kinase Inhibitor 627908 92 3 Genes associated with Kinase Inhibitor 627908-92-3, curated by the Drug Signature Database (DSigDB). (more detail) 146 25990557 Homo sapiens
MEX001712
Genes associated with Kinase Inhibitor HG6 64 1 Genes associated with Kinase Inhibitor HG6-64-1, curated by the Drug Signature Database (DSigDB). (more detail) 145 25990557 Homo sapiens
TAX013278
GO:0000151 cellular component ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase acti (more detail) 304 NA Homo sapiens
MEX002396
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 140 25990557 Homo sapiens
TAX015958
GO:0005829 cellular component cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate (more detail) 4846 NA Homo sapiens
TAX022935
GO:0035556 biological process intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become ac (more detail) 1481 NA Homo sapiens
TAX026202
GO:0048522 biological process positive regulation of cellular process Any process that activates or increases the frequency, rate or extent of a cellular process, any of (more detail) 4935 NA Homo sapiens
MEX002010
Genes associated with Kinase Inhibitor MLS006011171 Genes associated with Kinase Inhibitor MLS006011171, curated by the Drug Signature Database (DSigDB) (more detail) 142 25990557 Homo sapiens
TAX024652
GO:0044265 biological process cellular macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecul (more detail) 750 NA Homo sapiens
TAX015894
GO:0005737 cellular component cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcell (more detail) 4130 NA Homo sapiens
TAX026894
GO:0051247 biological process positive regulation of protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 1570 NA Homo sapiens
MEX002403
Genes associated with Kinase Inhibitor Crizotinib Genes associated with Kinase Inhibitor Crizotinib, curated by the Drug Signature Database (DSigDB). (more detail) 137 25990557 Homo sapiens
TAX019811
GO:0019783 molecular function ubiquitin like protein specific protease activity Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin o (more detail) 131 NA Homo sapiens
MEX001421
Genes associated with Kinase Inhibitor Crizotinib Genes associated with Kinase Inhibitor Crizotinib, curated by the Drug Signature Database (DSigDB). (more detail) 135 25990557 Homo sapiens
TAX021423
GO:0032270 biological process positive regulation of cellular protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 1481 NA Homo sapiens
MEX001285
Genes associated with Kinase Inhibitor WH 4 023 Genes associated with Kinase Inhibitor WH-4-023, curated by the Drug Signature Database (DSigDB). (more detail) 136 25990557 Homo sapiens
MEX001848
Genes associated with Kinase Inhibitor Tg 101348 Genes associated with Kinase Inhibitor Tg-101348, curated by the Drug Signature Database (DSigDB). (more detail) 132 25990557 Homo sapiens
MEX001551
Genes associated with Kinase Inhibitor AZD4547 Genes associated with Kinase Inhibitor AZD4547, curated by the Drug Signature Database (DSigDB). (more detail) 126 25990557 Homo sapiens
MEX001881
Genes associated with Kinase Inhibitor K 252a, Nocardiopsis sp. Genes associated with Kinase Inhibitor K-252a, Nocardiopsis sp., curated by the Drug Signature Datab (more detail) 125 25990557 Homo sapiens
TAX000573
Genes annotated by the GO term GO:0006508. The hydrolysis of a peptide bond or bonds within a protein. (more detail) 184 NA Homo sapiens
TAX031464
GO:0101005 molecular function ubiquitinyl hydrolase activity Catalysis of the hydrolysis of ubiquitin from proteins and other molecules. (more detail) 123 NA Homo sapiens
TAX019096
GO:0016570 biological process histone modification The covalent alteration of one or more amino acid residues within a histone protein. (more detail) 352 NA Homo sapiens
TAX019220
GO:0016791 molecular function phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. (more detail) 278 NA Homo sapiens
TAX023391
GO:0036459 molecular function thiol dependent ubiquitinyl hydrolase activity Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bon (more detail) 122 NA Homo sapiens
TAX030184
GO:0080134 biological process regulation of response to stress Any process that modulates the frequency, rate or extent of a response to stress. Response to stress (more detail) 1361 NA Homo sapiens
TAX019095
GO:0016569 biological process covalent chromatin modification The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups (more detail) 362 NA Homo sapiens
TAX018972
GO:0016311 biological process dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. (more detail) 296 NA Homo sapiens
TAX026232
GO:0048584 biological process positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to (more detail) 2173 NA Homo sapiens
MEX002327
Genes associated with Kinase Inhibitor Midostaurin Genes associated with Kinase Inhibitor Midostaurin, curated by the Drug Signature Database (DSigDB). (more detail) 125 25990557 Homo sapiens
MEX002317
Genes associated with Kinase Inhibitor CGP74514A Genes associated with Kinase Inhibitor CGP74514A, curated by the Drug Signature Database (DSigDB). (more detail) 122 25990557 Homo sapiens
MEX001667
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 116 25990557 Homo sapiens
MEX001279
Genes associated with Kinase Inhibitor AGN PC 04XSRZ Genes associated with Kinase Inhibitor AGN-PC-04XSRZ, curated by the Drug Signature Database (DSigDB (more detail) 119 25990557 Homo sapiens
MEX001869
Genes associated with Kinase Inhibitor Dabrafenib Genes associated with Kinase Inhibitor Dabrafenib, curated by the Drug Signature Database (DSigDB). (more detail) 121 25990557 Homo sapiens
MEX002416
Genes associated with Kinase Inhibitor Dabrafenib Genes associated with Kinase Inhibitor Dabrafenib, curated by the Drug Signature Database (DSigDB). (more detail) 121 25990557 Homo sapiens
TAX015036
GO:0004222 molecular function metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 113 NA Homo sapiens
TAX017820
GO:0009966 biological process regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. (more detail) 3036 NA Homo sapiens
TAX026199
GO:0048519 biological process negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. (more detail) 4829 NA Homo sapiens
TAX013940
GO:0001932 biological process regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an ami (more detail) 1366 NA Homo sapiens
MEX000921
Genes associated with Approved Drug dasatinib Genes associated with Approved Drug dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 144 25990557 Homo sapiens
MEX002025
Genes associated with Kinase Inhibitor PD173955 Genes associated with Kinase Inhibitor PD173955, curated by the Drug Signature Database (DSigDB). (more detail) 114 25990557 Homo sapiens
TAX017146
GO:0008238 molecular function exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus (more detail) 111 NA Homo sapiens
TAX026849
GO:0051174 biological process regulation of phosphorus metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 1662 NA Homo sapiens
TAX019645
GO:0019220 biological process regulation of phosphate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 1660 NA Homo sapiens
TAX023777
GO:0042325 biological process regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into a mole (more detail) 1465 NA Homo sapiens
WIG000921
Genes involved in Immune System (more detail) 893 NA Homo sapiens
TAX020240
GO:0023051 biological process regulation of signaling Any process that modulates the frequency, rate or extent of a signaling process. (more detail) 3402 NA Homo sapiens
TAX017472
GO:0009056 biological process catabolic process The chemical reactions and pathways resulting in the breakdown of substances, including the breakdow (more detail) 1788 NA Homo sapiens
TAX001152
Genes annotated by the GO term GO:0004175. Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub subclasses EC:3.4.21 99. They are classfied according to the presence of essential catalytic residues or ions at their active sites. (more detail) 114 NA Homo sapiens
MEX001267
Genes associated with Kinase Inhibitor OTSSP167 Genes associated with Kinase Inhibitor OTSSP167, curated by the Drug Signature Database (DSigDB). (more detail) 108 25990557 Homo sapiens
TAX020341
GO:0030163 biological process protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of th (more detail) 368 NA Homo sapiens
TAX018027
GO:0010646 biological process regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication i (more detail) 3375 NA Homo sapiens
TAX017992
GO:0010604 biological process positive regulation of macromolecule metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 3056 NA Homo sapiens
MEX000804
Genes associated with Approved Drug sorafenib Genes associated with Approved Drug sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 115 25990557 Homo sapiens
TAX029047
GO:0070646 biological process protein modification by small protein removal A protein modification process in which one or more covalently attached groups of a small protein, s (more detail) 285 NA Homo sapiens
TAX026203
GO:0048523 biological process negative regulation of cellular process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, an (more detail) 4334 NA Homo sapiens
MEX000922
Genes associated with Approved Drug vandetanib Genes associated with Approved Drug vandetanib, curated by the Drug Signature Database (DSigDB). (more detail) 114 25990557 Homo sapiens
TAX020969
GO:0031401 biological process positive regulation of protein modification process Any process that activates or increases the frequency, rate or extent of the covalent alteration of (more detail) 1136 NA Homo sapiens
TAX026848
GO:0051173 biological process positive regulation of nitrogen compound metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 2921 NA Homo sapiens
TAX019871
GO:0019899 molecular function enzyme binding Interacting selectively and non-covalently with any enzyme. (more detail) 2186 NA Homo sapiens
TAX016809
GO:0007165 biological process signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a (more detail) 4709 NA Homo sapiens
TAX017797
GO:0009893 biological process positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 3295 NA Homo sapiens
TAX016695
GO:0006950 biological process response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 2884 NA Homo sapiens
MEX002097
Genes associated with Kinase Inhibitor 1092351 67 1 Genes associated with Kinase Inhibitor 1092351-67-1, curated by the Drug Signature Database (DSigDB) (more detail) 120 25990557 Homo sapiens
TAX027156
GO:0051716 biological process cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 2605 NA Homo sapiens
TAX019105
GO:0016579 biological process protein deubiquitination The removal of one or more ubiquitin groups from a protein. (more detail) 269 NA Homo sapiens
TAX020925
GO:0031325 biological process positive regulation of cellular metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 3034 NA Homo sapiens
TAX015346
GO:0004725 molecular function protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. (more detail) 102 NA Homo sapiens
TAX022824
GO:0035335 biological process peptidyl tyrosine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. (more detail) 102 NA Homo sapiens
MEX001932
Genes associated with Kinase Inhibitor Crizotinib Genes associated with Kinase Inhibitor Crizotinib, curated by the Drug Signature Database (DSigDB). (more detail) 101 25990557 Homo sapiens
MEX001316
Genes associated with Kinase Inhibitor 405169 16 6 Genes associated with Kinase Inhibitor 405169-16-6, curated by the Drug Signature Database (DSigDB). (more detail) 103 25990557 Homo sapiens
MEX001715
Genes associated with Kinase Inhibitor PHA 767491 Genes associated with Kinase Inhibitor PHA-767491, curated by the Drug Signature Database (DSigDB). (more detail) 100 25990557 Homo sapiens
MEX002187
Genes associated with Kinase Inhibitor Antibiotic K 252a Genes associated with Kinase Inhibitor Antibiotic K 252a, curated by the Drug Signature Database (DS (more detail) 100 25990557 Homo sapiens
MEX001460
Genes associated with Kinase Inhibitor CP 466722 Genes associated with Kinase Inhibitor CP-466722, curated by the Drug Signature Database (DSigDB). (more detail) 117 25990557 Homo sapiens
TAX015849
GO:0005654 cellular component nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus. (more detail) 3045 NA Homo sapiens
MEX002384
Genes associated with Kinase Inhibitor A 443654 Genes associated with Kinase Inhibitor A-443654, curated by the Drug Signature Database (DSigDB). (more detail) 104 25990557 Homo sapiens
TAX024744
GO:0044428 cellular component nuclear part Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chrom (more detail) 4273 NA Homo sapiens
MEX002223
Genes associated with Kinase Inhibitor CHEMBL1908395 Genes associated with Kinase Inhibitor CHEMBL1908395, curated by the Drug Signature Database (DSigDB (more detail) 99 25990557 Homo sapiens
TAX023908
GO:0042578 molecular function phosphoric ester hydrolase activity Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosph (more detail) 370 NA Homo sapiens
MEX001872
Genes associated with Kinase Inhibitor Cdk1/2 Inhibitor III Genes associated with Kinase Inhibitor Cdk1/2 Inhibitor III, curated by the Drug Signature Database (more detail) 95 25990557 Homo sapiens
WIG000698
Genes involved in Antigen processing: Ubiquitination & Proteasome degradation (more detail) 199 NA Homo sapiens
TAX020229
GO:0023014 biological process signal transduction by protein phosphorylation A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to (more detail) 319 NA Homo sapiens
IEI014567
Protein protein interactors of human gene UBE2D2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2D2 (SwissProt ID (more detail) 211 17535438 Homo sapiens
TAX028676
GO:0065009 biological process regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biolo (more detail) 3093 NA Homo sapiens
MEX001763
Genes associated with Kinase Inhibitor PKR Inhibitor Genes associated with Kinase Inhibitor PKR Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 92 25990557 Homo sapiens
MEX002413
Genes associated with Kinase Inhibitor Ponatinib Genes associated with Kinase Inhibitor Ponatinib, curated by the Drug Signature Database (DSigDB). (more detail) 90 25990557 Homo sapiens
TAX017168
GO:0008276 molecular function protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein. (more detail) 90 NA Homo sapiens
MEX001047
Genes associated with Approved Drug axitinib Genes associated with Approved Drug axitinib, curated by the Drug Signature Database (DSigDB). (more detail) 104 25990557 Homo sapiens
IEI014566
Protein protein interactors of human gene UBE2D1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2D1 (SwissProt ID (more detail) 247 17535438 Homo sapiens
MEX001740
Genes associated with Kinase Inhibitor A 770041 Genes associated with Kinase Inhibitor A-770041, curated by the Drug Signature Database (DSigDB). (more detail) 92 25990557 Homo sapiens
WIG000638
Ubiquitin mediated proteolysis Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions (more detail) 130 NA Homo sapiens
TAX015034
GO:0004197 molecular function cysteine type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 87 NA Homo sapiens
MEX001604
Genes associated with Kinase Inhibitor BRD K29385665 001 01 1 Genes associated with Kinase Inhibitor BRD-K29385665-001-01-1, curated by the Drug Signature Databas (more detail) 86 25990557 Homo sapiens
IEI014568
Protein protein interactors of human gene UBE2D3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2D3 (SwissProt ID (more detail) 202 17535438 Homo sapiens
TAX017939
GO:0010498 biological process proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 279 NA Homo sapiens
WIG000763
Genes involved in Class I MHC mediated antigen processing & presentation (more detail) 237 NA Homo sapiens
MEX001840
Genes associated with Kinase Inhibitor SB 218078 Genes associated with Kinase Inhibitor SB 218078, curated by the Drug Signature Database (DSigDB). (more detail) 83 25990557 Homo sapiens
WAG000988
Ubiquitin mediated proteolysis Protein ubiquitition plays an important role in eukaryotic cellular processes. It mainly functions a (more detail) 121 NA Homo sapiens
MEX002344
Genes associated with Kinase Inhibitor staurosporine Genes associated with Kinase Inhibitor staurosporine, curated by the Drug Signature Database (DSigDB (more detail) 82 25990557 Homo sapiens
MEX002312
Genes associated with Kinase Inhibitor Tozasertib Genes associated with Kinase Inhibitor Tozasertib, curated by the Drug Signature Database (DSigDB). (more detail) 87 25990557 Homo sapiens
TAX024191
GO:0043161 biological process proteasome mediated ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 257 NA Homo sapiens
MEX002053
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 81 25990557 Homo sapiens
MEX002399
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 81 25990557 Homo sapiens
TAX019496
GO:0018210 biological process peptidyl threonine modification The modification of peptidyl-threonine. (more detail) 86 NA Homo sapiens
MEX001415
Genes associated with Kinase Inhibitor Kinome 3629 Genes associated with Kinase Inhibitor Kinome_3629, curated by the Drug Signature Database (DSigDB). (more detail) 80 25990557 Homo sapiens
TAX015433
GO:0004843 molecular function thiol dependent ubiquitin specific protease activity Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ub (more detail) 79 NA Homo sapiens
MOX013004
Genes associated with Computational Drug Signature hesperadin Genes associated with Computational Drug Signature hesperadin, curated by the Drug Signature Databas (more detail) 79 25990557 Homo sapiens
MEX001819
Genes associated with Kinase Inhibitor Palbociclib Genes associated with Kinase Inhibitor Palbociclib, curated by the Drug Signature Database (DSigDB). (more detail) 83 25990557 Homo sapiens
MEX002400
Genes associated with Kinase Inhibitor Palbociclib Genes associated with Kinase Inhibitor Palbociclib, curated by the Drug Signature Database (DSigDB). (more detail) 83 25990557 Homo sapiens
TAX019627
GO:0019199 molecular function transmembrane receptor protein kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 77 NA Homo sapiens
TAX013286
GO:0000165 biological process MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade (more detail) 294 NA Homo sapiens
PEX002586
Pkinase Tyr: Protein tyrosine kinase (more detail) 76 NA Homo sapiens
MEX001742
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 78 25990557 Homo sapiens
TAX021009
GO:0031461 cellular component cullin RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family a (more detail) 176 NA Homo sapiens
TAX019047
GO:0016485 biological process protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. (more detail) 147 NA Homo sapiens
MEX001982
Genes associated with Kinase Inhibitor Aurora A Inhibitor I Genes associated with Kinase Inhibitor Aurora A Inhibitor I, curated by the Drug Signature Database (more detail) 80 25990557 Homo sapiens
TAX017929
GO:0010468 biological process regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the (more detail) 4511 NA Homo sapiens
TAX019462
GO:0018107 biological process peptidyl threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. (more detail) 79 NA Homo sapiens
TAX001309
Genes annotated by the GO term GO:0004721. Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. (more detail) 78 NA Homo sapiens
MEX001238
Genes associated with Kinase Inhibitor A 674563 Genes associated with Kinase Inhibitor A-674563, curated by the Drug Signature Database (DSigDB). (more detail) 75 25990557 Homo sapiens
TAX021916
GO:0032991 cellular component protein containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipi (more detail) 4915 NA Homo sapiens
MEX000761
Genes associated with Approved Drug gefitinib Genes associated with Approved Drug gefitinib, curated by the Drug Signature Database (DSigDB). (more detail) 88 25990557 Homo sapiens
TAX015344
GO:0004722 molecular function protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein (more detail) 71 NA Homo sapiens
TAX017133
GO:0008213 biological process protein alkylation The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an (more detail) 123 NA Homo sapiens
TAX016361
GO:0006479 biological process protein methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by th (more detail) 123 NA Homo sapiens
MEX001926
Genes associated with Kinase Inhibitor AGN PC 045KSD Genes associated with Kinase Inhibitor AGN-PC-045KSD, curated by the Drug Signature Database (DSigDB (more detail) 85 25990557 Homo sapiens
TAX021604
GO:0032502 biological process developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anat (more detail) 4753 NA Homo sapiens
MEX001550
Genes associated with Kinase Inhibitor Cyt387 Genes associated with Kinase Inhibitor Cyt387, curated by the Drug Signature Database (DSigDB). (more detail) 65 25990557 Homo sapiens
FOX000436
Genes in the cancer module 107 (more detail) 78 NA Homo sapiens
MEX002414
Genes associated with Kinase Inhibitor Ruzolitinib Genes associated with Kinase Inhibitor Ruzolitinib, curated by the Drug Signature Database (DSigDB). (more detail) 63 25990557 Homo sapiens
TAX018954
GO:0016279 molecular function protein lysine N methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group (more detail) 62 NA Homo sapiens
TAX029031
GO:0070613 biological process regulation of protein processing Any process that modulates the frequency, rate or extent of protein processing, any protein maturati (more detail) 173 NA Homo sapiens
TAX023491
GO:0038095 biological process Fc epsilon receptor signaling pathway A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) t (more detail) 121 NA Homo sapiens
IEI014585
Protein protein interactors of human gene UBE2N from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2N (SwissProt ID= (more detail) 191 17535438 Homo sapiens
MEX001346
Genes associated with Kinase Inhibitor WZ4002 Genes associated with Kinase Inhibitor WZ4002, curated by the Drug Signature Database (DSigDB). (more detail) 64 25990557 Homo sapiens
TAX018835
GO:0016043 biological process cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellul (more detail) 4875 NA Homo sapiens
TAX032889
GO:1903317 biological process regulation of protein maturation Any process that modulates the frequency, rate or extent of protein maturation. (more detail) 175 NA Homo sapiens
TAX015339
GO:0004714 molecular function transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 61 NA Homo sapiens
MEX001543
Genes associated with Kinase Inhibitor Ruxolitinib Genes associated with Kinase Inhibitor Ruxolitinib, curated by the Drug Signature Database (DSigDB). (more detail) 61 25990557 Homo sapiens
MOX015198
Genes associated with Computational Drug Signature staurosporine Genes associated with Computational Drug Signature staurosporine, curated by the Drug Signature Data (more detail) 120 25990557 Homo sapiens
MEX002376
Genes associated with Kinase Inhibitor PHA 665752 Genes associated with Kinase Inhibitor PHA-665752, curated by the Drug Signature Database (DSigDB). (more detail) 63 25990557 Homo sapiens
TAX018953
GO:0016278 molecular function lysine N methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group (more detail) 63 NA Homo sapiens
TAX029699
GO:0071840 biological process cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of c (more detail) 4929 NA Homo sapiens
TAX017143
GO:0008235 molecular function metalloexopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus (more detail) 60 NA Homo sapiens
TAX017100
GO:0008170 molecular function N methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. (more detail) 95 NA Homo sapiens
MEX002406
Genes associated with Kinase Inhibitor Sorafenib Genes associated with Kinase Inhibitor Sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 59 25990557 Homo sapiens
TAX023646
GO:0042054 molecular function histone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-hi (more detail) 59 NA Homo sapiens
TAX001312
Genes annotated by the GO term GO:0016791. Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. (more detail) 107 NA Homo sapiens
MEX001850
Genes associated with Kinase Inhibitor AGN PC 0D0DBW Genes associated with Kinase Inhibitor AGN-PC-0D0DBW, curated by the Drug Signature Database (DSigDB (more detail) 62 25990557 Homo sapiens
MEX002134
Genes associated with Kinase Inhibitor BRD K83972459 001 01 9 Genes associated with Kinase Inhibitor BRD-K83972459-001-01-9, curated by the Drug Signature Databas (more detail) 64 25990557 Homo sapiens
MEX001357
Genes associated with Kinase Inhibitor BX 795 Genes associated with Kinase Inhibitor BX-795, curated by the Drug Signature Database (DSigDB). (more detail) 56 25990557 Homo sapiens
MEX002129
Genes associated with Kinase Inhibitor Flavopiridol Genes associated with Kinase Inhibitor Flavopiridol, curated by the Drug Signature Database (DSigDB) (more detail) 58 25990557 Homo sapiens
TAX027224
GO:0051865 biological process protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an ide (more detail) 58 NA Homo sapiens
MEX001371
Genes associated with Kinase Inhibitor Sorafenib Genes associated with Kinase Inhibitor Sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 55 25990557 Homo sapiens
MEX001456
Genes associated with Kinase Inhibitor Vandetanib Genes associated with Kinase Inhibitor Vandetanib, curated by the Drug Signature Database (DSigDB). (more detail) 55 25990557 Homo sapiens
MEX002061
Genes associated with Kinase Inhibitor 878739 06 1 Genes associated with Kinase Inhibitor 878739-06-1, curated by the Drug Signature Database (DSigDB). (more detail) 55 25990557 Homo sapiens
MEX002395
Genes associated with Kinase Inhibitor Vandetanib Genes associated with Kinase Inhibitor Vandetanib, curated by the Drug Signature Database (DSigDB). (more detail) 55 25990557 Homo sapiens
MEX002358
Genes associated with Kinase Inhibitor JAK3 Inhibitor VI Genes associated with Kinase Inhibitor JAK3 Inhibitor VI, curated by the Drug Signature Database (DS (more detail) 55 25990557 Homo sapiens
TAX019445
GO:0018022 biological process peptidyl lysine methylation The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. (more detail) 79 NA Homo sapiens
WIG001717
Ubiquitin Proteasome Dependent Proteolysis Ubiquitin-Proteasome Dependent Proteolysis (more detail) 77 NA Homo sapiens
MEX001204
Genes associated with Kinase Inhibitor Ro 31 8220 mesylate Genes associated with Kinase Inhibitor Ro 31-8220 mesylate, curated by the Drug Signature Database ( (more detail) 54 25990557 Homo sapiens
MEX002381
Genes associated with Kinase Inhibitor Neratinib Genes associated with Kinase Inhibitor Neratinib, curated by the Drug Signature Database (DSigDB). (more detail) 54 25990557 Homo sapiens
TAX000536
Genes annotated by the GO term GO:0006470. The process of removing one or more phosphoric residues from a protein. (more detail) 61 NA Homo sapiens
TAX001341
Genes annotated by the GO term GO:0004713. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. (more detail) 63 NA Homo sapiens
IEI014571
Protein protein interactors of human gene UBE2E1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2E1 (SwissProt ID (more detail) 125 17535438 Homo sapiens
MEX001227
Genes associated with Kinase Inhibitor 718630 59 2 Genes associated with Kinase Inhibitor 718630-59-2, curated by the Drug Signature Database (DSigDB). (more detail) 53 25990557 Homo sapiens
TAX020517
GO:0030449 biological process regulation of complement activation Any process that modulates the frequency, rate or extent of complement activation. (more detail) 111 NA Homo sapiens
TAX034561
GO:2000257 biological process regulation of protein activation cascade Any process that modulates the frequency, rate or extent of protein activation cascade. (more detail) 112 NA Homo sapiens
TAX019494
GO:0018208 biological process peptidyl proline modification The modification of peptidyl-proline. (more detail) 55 NA Homo sapiens
TAX021011
GO:0031463 cellular component Cul3 RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form (more detail) 71 NA Homo sapiens
MEX002048
Genes associated with Kinase Inhibitor 1,9 Pyrazoloanthrone Genes associated with Kinase Inhibitor 1,9-Pyrazoloanthrone, curated by the Drug Signature Database (more detail) 52 25990557 Homo sapiens
MOX003562
Genes associated with Computational Drug Signature PONATINIB Genes associated with Computational Drug Signature PONATINIB, curated by the Drug Signature Database (more detail) 59 25990557 Homo sapiens
TAX014516
GO:0002920 biological process regulation of humoral immune response Any process that modulates the frequency, rate, or extent of a humoral immune response. (more detail) 130 NA Homo sapiens
TAX015340
GO:0004715 molecular function non membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-me (more detail) 51 NA Homo sapiens
TAX001439
Genes annotated by the GO term GO:0019199. (more detail) 51 NA Homo sapiens
IEI007770
Protein protein interactors of human gene MBP from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MBP (SwissProt ID=P0 (more detail) 80 17535438 Homo sapiens
PEX000656
Trypsin: Trypsin (more detail) 53 NA Homo sapiens
TAX001129
Genes annotated by the GO term GO:0008234. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. (more detail) 50 NA Homo sapiens
MEX002421
Genes associated with Kinase Inhibitor Cabozantinib Genes associated with Kinase Inhibitor Cabozantinib, curated by the Drug Signature Database (DSigDB) (more detail) 50 25990557 Homo sapiens
TAX001342
Genes annotated by the GO term GO:0004725. Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. (more detail) 52 NA Homo sapiens
TAX014234
GO:0002433 biological process immune response regulating cell surface receptor signaling pathway involved in phagocytosis An immune response-regulating cell surface receptor signaling pathway that contributes to the endocy (more detail) 133 NA Homo sapiens
TAX023492
GO:0038096 biological process Fc gamma receptor signaling pathway involved in phagocytosis An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external part (more detail) 133 NA Homo sapiens
MEX001333
Genes associated with Kinase Inhibitor Staurosporine, N Benzoyl Genes associated with Kinase Inhibitor Staurosporine, N-Benzoyl, curated by the Drug Signature Datab (more detail) 49 25990557 Homo sapiens
MEX002248
Genes associated with Kinase Inhibitor Go 6976 Genes associated with Kinase Inhibitor Go 6976, curated by the Drug Signature Database (DSigDB). (more detail) 49 25990557 Homo sapiens
TAX023482
GO:0038083 biological process peptidyl tyrosine autophosphorylation The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosi (more detail) 49 NA Homo sapiens
FEX001656
Leukemia Tavolaro10 56genes Table 3. PK genes highly and specifically expressed in CLL. (more detail) 51 20036005 Homo sapiens
TAX001387
Genes annotated by the GO term GO:0008639. Catalysis of the covalent attachment of small proteins, such as ubiquitin or ubiquitin like proteins, to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3, ubiquitin like protein ligase. (more detail) 51 NA Homo sapiens
TAX019097
GO:0016571 biological process histone methylation The modification of histones by addition of methyl groups. (more detail) 84 NA Homo sapiens
TAX000157
Genes annotated by the GO term GO:0016311. The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. (more detail) 67 NA Homo sapiens
FOX000503
Genes in the cancer module 172 (more detail) 95 NA Homo sapiens
WIG001490
Estrogen Pathway Estrogen Pathway (more detail) 113 NA Homo sapiens
TAX001383
Genes annotated by the GO term GO:0019787. Catalysis of ATP dependent isopeptide bond formation between the carboxy terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin like protein, and a substrate lysine residue. (more detail) 50 NA Homo sapiens
MEX001851
Genes associated with Kinase Inhibitor GW305074X Genes associated with Kinase Inhibitor GW305074X, curated by the Drug Signature Database (DSigDB). (more detail) 54 25990557 Homo sapiens
MEX001248
Genes associated with Kinase Inhibitor Ro 3306 Genes associated with Kinase Inhibitor Ro-3306, curated by the Drug Signature Database (DSigDB). (more detail) 47 25990557 Homo sapiens
MEX001345
Genes associated with Kinase Inhibitor GSK690693 Genes associated with Kinase Inhibitor GSK690693, curated by the Drug Signature Database (DSigDB). (more detail) 47 25990557 Homo sapiens
TAX019447
GO:0018024 molecular function histone lysine N methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + (more detail) 47 NA Homo sapiens
MEX001876
Genes associated with Kinase Inhibitor AZD 9291 Genes associated with Kinase Inhibitor AZD-9291, curated by the Drug Signature Database (DSigDB). (more detail) 49 25990557 Homo sapiens
MEX002045
Genes associated with Kinase Inhibitor Cediranib Genes associated with Kinase Inhibitor Cediranib, curated by the Drug Signature Database (DSigDB). (more detail) 46 25990557 Homo sapiens
TAX022138
GO:0033558 molecular function protein deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. (more detail) 46 NA Homo sapiens
TAX015029
GO:0004177 molecular function aminopeptidase activity Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. (more detail) 46 NA Homo sapiens
TAX001245
Genes annotated by the GO term GO:0008237. (more detail) 48 NA Homo sapiens
TAX001445
Genes annotated by the GO term GO:0004842. Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N ubiquityllysine. (more detail) 48 NA Homo sapiens
TAX029196
GO:0070936 biological process protein K48 linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine (more detail) 48 NA Homo sapiens
MEX002029
Genes associated with Kinase Inhibitor SU11652 Genes associated with Kinase Inhibitor SU11652, curated by the Drug Signature Database (DSigDB). (more detail) 45 25990557 Homo sapiens
TAX017083
GO:0008138 molecular function protein tyrosine/serine/threonine phosphatase activity Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine pho (more detail) 45 NA Homo sapiens
MEX002401
Genes associated with Kinase Inhibitor Pazopanib Genes associated with Kinase Inhibitor Pazopanib, curated by the Drug Signature Database (DSigDB). (more detail) 49 25990557 Homo sapiens
MEX001534
Genes associated with Kinase Inhibitor Pazopanib Genes associated with Kinase Inhibitor Pazopanib, curated by the Drug Signature Database (DSigDB). (more detail) 49 25990557 Homo sapiens
MEX002205
Genes associated with Kinase Inhibitor PKR Inhibitor Genes associated with Kinase Inhibitor PKR Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 44 25990557 Homo sapiens
TAX015117
GO:0004407 molecular function histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This react (more detail) 44 NA Homo sapiens
TAX015030
GO:0004180 molecular function carboxypeptidase activity Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a p (more detail) 44 NA Homo sapiens
FEX001679
Leukemia Messina10 53genes Table 3. PK Genes Distinctive of Each ALL Subgroup (more detail) 46 20564080 Homo sapiens
TAX001065
Genes annotated by the GO term GO:0016881. Catalysis of the ligation of an acid to an amino acid via a carbon nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. (more detail) 56 NA Homo sapiens
WIG000372
MAPKinase Signaling Pathway The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major group (more detail) 86 NA Homo sapiens
MEX001367
Genes associated with Kinase Inhibitor Linifanib Genes associated with Kinase Inhibitor Linifanib, curated by the Drug Signature Database (DSigDB). (more detail) 43 25990557 Homo sapiens
TAX001441
Genes annotated by the GO term GO:0004714. Catalysis of the reaction: ATP + a protein L tyrosine = ADP + a protein L tyrosine phosphate, to initiate a change in cell activity. (more detail) 43 NA Homo sapiens
TAX001372
Genes annotated by the GO term GO:0008236. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). (more detail) 45 NA Homo sapiens
MEX001977
Genes associated with Kinase Inhibitor MLN8054 Genes associated with Kinase Inhibitor MLN8054, curated by the Drug Signature Database (DSigDB). (more detail) 42 25990557 Homo sapiens
TAX015337
GO:0004712 molecular function protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein (more detail) 42 NA Homo sapiens
MEX002372
Genes associated with Kinase Inhibitor Sorafenib Genes associated with Kinase Inhibitor Sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 42 25990557 Homo sapiens
TAX001228
Genes annotated by the GO term GO:0016879. Catalysis of the ligation of two substances via a carbon nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. (more detail) 65 NA Homo sapiens
MEX000882
Genes associated with Approved Drug nilotinib Genes associated with Approved Drug nilotinib, curated by the Drug Signature Database (DSigDB). (more detail) 65 25990557 Homo sapiens
TAX022673
GO:0034968 biological process histone lysine methylation The modification of a histone by addition of one or more methyl groups to a lysine residue. (more detail) 65 NA Homo sapiens
MEX001577
Genes associated with Kinase Inhibitor 331771 20 1 Genes associated with Kinase Inhibitor 331771-20-1, curated by the Drug Signature Database (DSigDB). (more detail) 44 25990557 Homo sapiens
TAX031098
GO:0098732 biological process macromolecule deacylation The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, fro (more detail) 73 NA Homo sapiens
TAX001369
Genes annotated by the GO term GO:0017171. Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). (more detail) 46 NA Homo sapiens
WIG001729
Yersinia Infection Yersinia Infection (more detail) 79 NA Homo sapiens
MEX001296
Genes associated with Kinase Inhibitor Ruboxistaurin Genes associated with Kinase Inhibitor Ruboxistaurin, curated by the Drug Signature Database (DSigDB (more detail) 48 25990557 Homo sapiens
MEX002058
Genes associated with Kinase Inhibitor indirubin deriv. 7a Genes associated with Kinase Inhibitor indirubin deriv. 7a, curated by the Drug Signature Database ( (more detail) 41 25990557 Homo sapiens
MEX001533
Genes associated with Kinase Inhibitor SureCN3470757 Genes associated with Kinase Inhibitor SureCN3470757, curated by the Drug Signature Database (DSigDB (more detail) 41 25990557 Homo sapiens
MEX002347
Genes associated with Kinase Inhibitor 918505 84 7 Genes associated with Kinase Inhibitor 918505-84-7, curated by the Drug Signature Database (DSigDB). (more detail) 41 25990557 Homo sapiens
FOX000541
Genes in the cancer module 209 (more detail) 88 NA Homo sapiens
IEI014569
Protein protein interactors of human gene UBE2D4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2D4 (SwissProt ID (more detail) 98 17535438 Homo sapiens
TAX022970
GO:0035601 biological process protein deacylation The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, fro (more detail) 72 NA Homo sapiens
MEX002405
Genes associated with Kinase Inhibitor Vemurafenib Genes associated with Kinase Inhibitor Vemurafenib, curated by the Drug Signature Database (DSigDB). (more detail) 43 25990557 Homo sapiens
MEX002155
Genes associated with Kinase Inhibitor AGN PC 04XSIT Genes associated with Kinase Inhibitor AGN-PC-04XSIT, curated by the Drug Signature Database (DSigDB (more detail) 43 25990557 Homo sapiens
TAX013403
GO:0000413 biological process protein peptidyl prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue. (more detail) 40 NA Homo sapiens
TAX014787
GO:0003755 molecular function peptidyl prolyl cis trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). (more detail) 40 NA Homo sapiens
MEX001839
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX002035
Genes associated with Kinase Inhibitor GSK1838705A Genes associated with Kinase Inhibitor GSK1838705A, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX001834
Genes associated with Kinase Inhibitor 722544 51 6 Genes associated with Kinase Inhibitor 722544-51-6, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX001905
Genes associated with Kinase Inhibitor Axitinib Genes associated with Kinase Inhibitor Axitinib, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX002404
Genes associated with Kinase Inhibitor Axitinib Genes associated with Kinase Inhibitor Axitinib, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX002356
Genes associated with Kinase Inhibitor Dinaciclib Genes associated with Kinase Inhibitor Dinaciclib, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX001356
Genes associated with Kinase Inhibitor Vemurafenib Genes associated with Kinase Inhibitor Vemurafenib, curated by the Drug Signature Database (DSigDB). (more detail) 41 25990557 Homo sapiens
TAX001370
Genes annotated by the GO term GO:0004252. Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). (more detail) 41 NA Homo sapiens
MEX001976
Genes associated with Kinase Inhibitor SureCN186278 Genes associated with Kinase Inhibitor SureCN186278, curated by the Drug Signature Database (DSigDB) (more detail) 45 25990557 Homo sapiens
TAX030871
GO:0097472 molecular function cyclin dependent protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the rea (more detail) 38 NA Homo sapiens
MEX002420
Genes associated with Kinase Inhibitor Nilotinib Genes associated with Kinase Inhibitor Nilotinib, curated by the Drug Signature Database (DSigDB). (more detail) 38 25990557 Homo sapiens
MEX001769
Genes associated with Kinase Inhibitor GSK2606414 Genes associated with Kinase Inhibitor GSK2606414, curated by the Drug Signature Database (DSigDB). (more detail) 38 25990557 Homo sapiens
MEX001100
Genes associated with Approved Drug afatinib Genes associated with Approved Drug afatinib, curated by the Drug Signature Database (DSigDB). (more detail) 38 25990557 Homo sapiens
TAX028981
GO:0070534 biological process protein K63 linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine (more detail) 38 NA Homo sapiens
FOX000529
Genes in the cancer module 199 (more detail) 57 NA Homo sapiens
TAX019263
GO:0016859 molecular function cis trans isomerase activity Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or (more detail) 42 NA Homo sapiens
MEX002353
Genes associated with Kinase Inhibitor BRD K72636697 001 01 5 Genes associated with Kinase Inhibitor BRD-K72636697-001-01-5, curated by the Drug Signature Databas (more detail) 44 25990557 Homo sapiens
MEX001320
Genes associated with Kinase Inhibitor IKK Inhibitor VII Genes associated with Kinase Inhibitor IKK Inhibitor VII, curated by the Drug Signature Database (DS (more detail) 37 25990557 Homo sapiens
MEX001785
Genes associated with Kinase Inhibitor Kinome 1194 Genes associated with Kinase Inhibitor Kinome_1194, curated by the Drug Signature Database (DSigDB). (more detail) 37 25990557 Homo sapiens
TAX001128
Genes annotated by the GO term GO:0004197. Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. (more detail) 37 NA Homo sapiens
MEX002100
Genes associated with Kinase Inhibitor Nilotinib Genes associated with Kinase Inhibitor Nilotinib, curated by the Drug Signature Database (DSigDB). (more detail) 37 25990557 Homo sapiens
TAX015324
GO:0004693 molecular function cyclin dependent protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein (more detail) 37 NA Homo sapiens
MEX002186
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 37 25990557 Homo sapiens
FOX000438
Genes in the cancer module 109 (more detail) 39 NA Homo sapiens
WIG001611
p53 Signaling p53 Signaling (more detail) 84 NA Homo sapiens
MEX001723
Genes associated with Kinase Inhibitor SureCN10127740 Genes associated with Kinase Inhibitor SureCN10127740, curated by the Drug Signature Database (DSigD (more detail) 36 25990557 Homo sapiens
MEX001590
Genes associated with Kinase Inhibitor BMS 387032 Genes associated with Kinase Inhibitor BMS-387032, curated by the Drug Signature Database (DSigDB). (more detail) 36 25990557 Homo sapiens
MEX001454
Genes associated with Kinase Inhibitor Quercetagetin Genes associated with Kinase Inhibitor Quercetagetin, curated by the Drug Signature Database (DSigDB (more detail) 36 25990557 Homo sapiens
TAX019639
GO:0019213 molecular function deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. (more detail) 58 NA Homo sapiens
MEX001485
Genes associated with Kinase Inhibitor Syk Inhibitor Genes associated with Kinase Inhibitor Syk Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 35 25990557 Homo sapiens
MEX001696
Genes associated with Kinase Inhibitor Ki20227 Genes associated with Kinase Inhibitor Ki20227, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX002385
Genes associated with Kinase Inhibitor R547 Genes associated with Kinase Inhibitor R547, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX002126
Genes associated with Kinase Inhibitor 841290 80 0 Genes associated with Kinase Inhibitor 841290-80-0, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX001512
Genes associated with Kinase Inhibitor Doramapimod Genes associated with Kinase Inhibitor Doramapimod, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX001422
Genes associated with Kinase Inhibitor 929095 18 1 Genes associated with Kinase Inhibitor 929095-18-1, curated by the Drug Signature Database (DSigDB). (more detail) 45 25990557 Homo sapiens
TAX000542
Genes annotated by the GO term GO:0030163. The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. (more detail) 65 NA Homo sapiens
MEX001554
Genes associated with Kinase Inhibitor TAK 715 Genes associated with Kinase Inhibitor TAK-715, curated by the Drug Signature Database (DSigDB). (more detail) 34 25990557 Homo sapiens
WAG001226
ErbB signaling pathway The ErbB family of receptor tyrosine kises (RTKs) couples binding of extracellular growth factor lig (more detail) 75 NA Homo sapiens
TAX016358
GO:0006476 biological process protein deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from ac (more detail) 62 NA Homo sapiens
TAX001352
Genes annotated by the GO term GO:0004702. (more detail) 33 NA Homo sapiens
MEX002298
Genes associated with Kinase Inhibitor IPA 3 Genes associated with Kinase Inhibitor IPA-3, curated by the Drug Signature Database (DSigDB). (more detail) 33 25990557 Homo sapiens
MEX002418
Genes associated with Kinase Inhibitor Regorafenib Genes associated with Kinase Inhibitor Regorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 33 25990557 Homo sapiens
MEX002398
Genes associated with Kinase Inhibitor Erlotinib Genes associated with Kinase Inhibitor Erlotinib, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX002063
Genes associated with Kinase Inhibitor Erlotinib Genes associated with Kinase Inhibitor Erlotinib, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
TAX000561
Genes annotated by the GO term GO:0016485. The posttranslational modification of a protein, particularly secretory proteins and proteins targeted for membranes or specific cellular locations. (more detail) 48 NA Homo sapiens
MEX001438
Genes associated with Kinase Inhibitor Ro 3306 Genes associated with Kinase Inhibitor Ro-3306, curated by the Drug Signature Database (DSigDB). (more detail) 32 25990557 Homo sapiens
MEX002328
Genes associated with Kinase Inhibitor SureCN571763 Genes associated with Kinase Inhibitor SureCN571763, curated by the Drug Signature Database (DSigDB) (more detail) 32 25990557 Homo sapiens
TAX001238
Genes annotated by the GO term GO:0000287. Interacting selectively with magnesium (Mg) ions. (more detail) 59 NA Homo sapiens
TAX019101
GO:0016575 biological process histone deacetylation The modification of histones by removal of acetyl groups. (more detail) 60 NA Homo sapiens
TAX016383
GO:0006513 biological process protein monoubiquitination Addition of a single ubiquitin group to a protein. (more detail) 60 NA Homo sapiens
WIG001485
ErbB Family Pathway ErbB Family Pathway (more detail) 63 NA Homo sapiens
MEX001223
Genes associated with Kinase Inhibitor NVP TAE684 Genes associated with Kinase Inhibitor NVP-TAE684, curated by the Drug Signature Database (DSigDB). (more detail) 31 25990557 Homo sapiens
MEX002019
Genes associated with Kinase Inhibitor Canertinib Genes associated with Kinase Inhibitor Canertinib, curated by the Drug Signature Database (DSigDB). (more detail) 31 25990557 Homo sapiens
WIG001487
ErbB4 Pathway ErbB4 Pathway (more detail) 51 NA Homo sapiens
FOX000843
Genes in the cancer module 85 (more detail) 51 NA Homo sapiens
TAX000093
Genes annotated by the GO term GO:0044257. The chemical reactions and pathways resulting in the breakdown of a protein by individual cells. (more detail) 54 NA Homo sapiens
MEX001395
Genes associated with Kinase Inhibitor Indirubin Derivative E804 Genes associated with Kinase Inhibitor Indirubin Derivative E804, curated by the Drug Signature Data (more detail) 30 25990557 Homo sapiens
PEX001394
Y phosphatase: Protein tyrosine phosphatase (more detail) 30 NA Homo sapiens
MEX001409
Genes associated with Kinase Inhibitor PP242 Genes associated with Kinase Inhibitor PP242, curated by the Drug Signature Database (DSigDB). (more detail) 30 25990557 Homo sapiens
MEX001663
Genes associated with Kinase Inhibitor RAF265 Genes associated with Kinase Inhibitor RAF265, curated by the Drug Signature Database (DSigDB). (more detail) 30 25990557 Homo sapiens
TAX001160
Genes annotated by the GO term GO:0008238. Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. (more detail) 30 NA Homo sapiens
TAX028527
GO:0061650 molecular function ubiquitin like protein conjugating enzyme activity Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction (more detail) 30 NA Homo sapiens
TAX020194
GO:0022617 biological process extracellular matrix disassembly A process that results in the breakdown of the extracellular matrix. (more detail) 59 NA Homo sapiens
MEX002028
Genes associated with Kinase Inhibitor CHEMBL1673039 Genes associated with Kinase Inhibitor CHEMBL1673039, curated by the Drug Signature Database (DSigDB (more detail) 29 25990557 Homo sapiens
MEX001623
Genes associated with Kinase Inhibitor AT7519 Genes associated with Kinase Inhibitor AT7519, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
PEX001905
UQ con: Ubiquitin conjugating enzyme Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows c (more detail) 29 NA Homo sapiens
MEX002239
Genes associated with Kinase Inhibitor Kinome 635 Genes associated with Kinase Inhibitor Kinome_635, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
MEX001589
Genes associated with Kinase Inhibitor dorsomorphin Genes associated with Kinase Inhibitor dorsomorphin, curated by the Drug Signature Database (DSigDB) (more detail) 29 25990557 Homo sapiens
TAX029291
GO:0071108 biological process protein K48 linked deubiquitination A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquiti (more detail) 29 NA Homo sapiens
TAX021561
GO:0032452 molecular function histone demethylase activity Catalysis of the removal of a methyl group from a histone. (more detail) 29 NA Homo sapiens
MEX002250
Genes associated with Kinase Inhibitor BI D1870 Genes associated with Kinase Inhibitor BI-D1870, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
MEX001410
Genes associated with Kinase Inhibitor NG25 Genes associated with Kinase Inhibitor NG25, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
FOX000584
Genes in the cancer module 259 (more detail) 46 NA Homo sapiens
TAX019103
GO:0016577 biological process histone demethylation The modification of histones by removal of methyl groups. (more detail) 31 NA Homo sapiens
MAX003161
Genes that comprise the proteasome gene module A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genom (more detail) 49 NA Homo sapiens
TAX016364
GO:0006482 biological process protein demethylation The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by (more detail) 33 NA Homo sapiens
TAX017134
GO:0008214 biological process protein dealkylation The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an (more detail) 33 NA Homo sapiens
TAX000811
Genes annotated by the GO term GO:0006512. The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein. (more detail) 47 NA Homo sapiens
FEX000745
Breast Speers09 52genes IDKinasesOverExpressed Table 2. Kinases identified in analysis as most highly overexpressed in ER-negative tumors (more detail) 50 19808870 Homo sapiens
MOX012175
Genes associated with Computational Drug Signature Dasatinib Genes associated with Computational Drug Signature Dasatinib, curated by the Drug Signature Database (more detail) 50 25990557 Homo sapiens
TAX028519
GO:0061631 molecular function ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y (more detail) 28 NA Homo sapiens
TAX015031
GO:0004181 molecular function metallocarboxypeptidase activity Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanis (more detail) 28 NA Homo sapiens
MEX002007
Genes associated with Kinase Inhibitor GSK 650394 Genes associated with Kinase Inhibitor GSK 650394, curated by the Drug Signature Database (DSigDB). (more detail) 28 25990557 Homo sapiens
MEX001110
Genes associated with Approved Drug pazopanib hydrochloride Genes associated with Approved Drug pazopanib hydrochloride, curated by the Drug Signature Database (more detail) 28 25990557 Homo sapiens
TAX015317
GO:0004683 molecular function calmodulin dependent protein kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a pro (more detail) 28 NA Homo sapiens
MEX001704
Genes associated with Kinase Inhibitor ITK inhibitor Genes associated with Kinase Inhibitor ITK inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 28 25990557 Homo sapiens
MEX001287
Genes associated with Kinase Inhibitor BI 2536 Genes associated with Kinase Inhibitor BI 2536, curated by the Drug Signature Database (DSigDB). (more detail) 30 25990557 Homo sapiens
FEX000743
Breast Speers09 52genes OverExpressedNegativeCancer Supplementary Table 2: Kinases overexpressed in ER?negative breast cancer (more detail) 51 19808870 Homo sapiens
IEI014277
Protein protein interactors of human gene TRIM8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM8 (SwissProt ID= (more detail) 51 17535438 Homo sapiens
MEX001278
Genes associated with Kinase Inhibitor AGN PC 0INJ9Y Genes associated with Kinase Inhibitor AGN-PC-0INJ9Y, curated by the Drug Signature Database (DSigDB (more detail) 32 25990557 Homo sapiens
TAX024198
GO:0043171 biological process peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more ( (more detail) 32 NA Homo sapiens
MEX001616
Genes associated with Kinase Inhibitor AGN PC 087NKJ Genes associated with Kinase Inhibitor AGN-PC-087NKJ, curated by the Drug Signature Database (DSigDB (more detail) 27 25990557 Homo sapiens
TAX019783
GO:0019707 molecular function protein cysteine S acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule. (more detail) 27 NA Homo sapiens
MEX002246
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 27 25990557 Homo sapiens
MEX001642
Genes associated with Kinase Inhibitor AGN PC 04T5ZK Genes associated with Kinase Inhibitor AGN-PC-04T5ZK, curated by the Drug Signature Database (DSigDB (more detail) 27 25990557 Homo sapiens
TAX019782
GO:0019706 molecular function protein cysteine S palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecul (more detail) 27 NA Homo sapiens
WIG001413
VEGF Signaling Pathway Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevaci (more detail) 55 NA Homo sapiens
TAX020569
GO:0030574 biological process collagen catabolic process The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extrac (more detail) 37 NA Homo sapiens
TAX000556
Genes annotated by the GO term GO:0032446. A process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin like protein, are covalently attached to a target protein. (more detail) 42 NA Homo sapiens
PEX000431
DSPc: Dual specificity phosphatase, catalytic domain Ser/Thr and Tyr protein phosphatases. The enzymes tertiary fold is highly similar to that of tyrosin (more detail) 29 NA Homo sapiens
MOX007315
Genes associated with Computational Drug Signature bisindolylmaleimide iv Genes associated with Computational Drug Signature bisindolylmaleimide iv, curated by the Drug Signa (more detail) 29 25990557 Homo sapiens
TAX019011
GO:0016417 molecular function S acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. (more detail) 31 NA Homo sapiens
MEX001412
Genes associated with Kinase Inhibitor Tyrphostin AG 1478 Genes associated with Kinase Inhibitor Tyrphostin AG 1478, curated by the Drug Signature Database (D (more detail) 31 25990557 Homo sapiens
TAX028678
GO:0070001 molecular function aspartic type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water (more detail) 26 NA Homo sapiens
TAX015335
GO:0004709 molecular function MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can b (more detail) 26 NA Homo sapiens
MEX002214
Genes associated with Kinase Inhibitor 3ztx Genes associated with Kinase Inhibitor 3ztx, curated by the Drug Signature Database (DSigDB). (more detail) 26 25990557 Homo sapiens
MEX002158
Genes associated with Kinase Inhibitor Enzastaurin Genes associated with Kinase Inhibitor Enzastaurin, curated by the Drug Signature Database (DSigDB). (more detail) 26 25990557 Homo sapiens
MEX002195
Genes associated with Kinase Inhibitor BX 912 Genes associated with Kinase Inhibitor BX-912, curated by the Drug Signature Database (DSigDB). (more detail) 26 25990557 Homo sapiens
MEX002192
Genes associated with Kinase Inhibitor ILORASERTIB Genes associated with Kinase Inhibitor ILORASERTIB, curated by the Drug Signature Database (DSigDB). (more detail) 26 25990557 Homo sapiens
TAX028715
GO:0070076 biological process histone lysine demethylation The modification of a histone by the removal of a methyl group from a lysine residue. (more detail) 28 NA Homo sapiens
MEX001261
Genes associated with Kinase Inhibitor Torin 1 Genes associated with Kinase Inhibitor Torin 1, curated by the Drug Signature Database (DSigDB). (more detail) 28 25990557 Homo sapiens
MEX002110
Genes associated with Kinase Inhibitor AGN PC 0HSSYL Genes associated with Kinase Inhibitor AGN-PC-0HSSYL, curated by the Drug Signature Database (DSigDB (more detail) 30 25990557 Homo sapiens
TAX000570
Genes annotated by the GO term GO:0016567. The process by which one or more ubiquitin moieties are added to a protein. (more detail) 39 NA Homo sapiens
WIG001587
Alzheimer¿s Disease Pathway Alzheimer¿s Disease Pathway (more detail) 42 NA Homo sapiens
MEX001658
Genes associated with Kinase Inhibitor GW768505A Genes associated with Kinase Inhibitor GW768505A, curated by the Drug Signature Database (DSigDB). (more detail) 25 25990557 Homo sapiens
TAX015033
GO:0004190 molecular function aspartic type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 25 NA Homo sapiens
MEX002062
Genes associated with Kinase Inhibitor Crenolanib Genes associated with Kinase Inhibitor Crenolanib, curated by the Drug Signature Database (DSigDB). (more detail) 25 25990557 Homo sapiens
TAX013301
GO:0000186 biological process activation of MAPKK activity The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). (more detail) 51 NA Homo sapiens
TAX001243
Genes annotated by the GO term GO:0004222. Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. (more detail) 27 NA Homo sapiens
TAX000541
Genes annotated by the GO term GO:0016540. Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. (more detail) 31 NA Homo sapiens
WIG000133
Regulation of p38 alpha and p38 beta (more detail) 31 NA Homo sapiens
WIG000791
Genes involved in Degradation of the extracellular matrix (more detail) 29 NA Homo sapiens
WIG000969
Genes involved in MAP kinase activation in TLR cascade (more detail) 49 NA Homo sapiens
MEX001309
Genes associated with Kinase Inhibitor CHEMBL552425 Genes associated with Kinase Inhibitor CHEMBL552425, curated by the Drug Signature Database (DSigDB) (more detail) 24 25990557 Homo sapiens
MEX002337
Genes associated with Kinase Inhibitor su6656 Genes associated with Kinase Inhibitor su6656, curated by the Drug Signature Database (DSigDB). (more detail) 24 25990557 Homo sapiens
MEX001535
Genes associated with Kinase Inhibitor go 7874 Genes associated with Kinase Inhibitor go 7874, curated by the Drug Signature Database (DSigDB). (more detail) 24 25990557 Homo sapiens
MEX001794
Genes associated with Kinase Inhibitor MLN8054 Genes associated with Kinase Inhibitor MLN8054, curated by the Drug Signature Database (DSigDB). (more detail) 24 25990557 Homo sapiens
TAX019816
GO:0019789 molecular function SUMO transferase activity Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO (more detail) 24 NA Homo sapiens
TAX001338
Genes annotated by the GO term GO:0004722. Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. (more detail) 24 NA Homo sapiens
MEX002139
Genes associated with Kinase Inhibitor JAK Inhibitor I Genes associated with Kinase Inhibitor JAK Inhibitor I, curated by the Drug Signature Database (DSig (more detail) 24 25990557 Homo sapiens
MEX002386
Genes associated with Kinase Inhibitor GW843682X Genes associated with Kinase Inhibitor GW843682X, curated by the Drug Signature Database (DSigDB). (more detail) 30 25990557 Homo sapiens
TAX000535
Genes annotated by the GO term GO:0046777. The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. (more detail) 30 NA Homo sapiens
TAX019098
GO:0016572 biological process histone phosphorylation The modification of histones by addition of phosphate groups. (more detail) 28 NA Homo sapiens
MEX002221
Genes associated with Kinase Inhibitor Sunitinib Genes associated with Kinase Inhibitor Sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 23 25990557 Homo sapiens
MEX001418
Genes associated with Kinase Inhibitor TSU 68 Genes associated with Kinase Inhibitor TSU-68, curated by the Drug Signature Database (DSigDB). (more detail) 23 25990557 Homo sapiens
MEX002057
Genes associated with Kinase Inhibitor Kinome 800 Genes associated with Kinase Inhibitor Kinome_800, curated by the Drug Signature Database (DSigDB). (more detail) 23 25990557 Homo sapiens
MEX002206
Genes associated with Kinase Inhibitor BI 2536 Genes associated with Kinase Inhibitor BI 2536, curated by the Drug Signature Database (DSigDB). (more detail) 23 25990557 Homo sapiens
TAX031709
GO:0140103 molecular function catalytic activity, acting on a glycoprotein catalytic activity, acting on a glycosylated protein (more detail) 23 NA Homo sapiens
TAX028682
GO:0070006 molecular function metalloaminopeptidase activity Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanis (more detail) 23 NA Homo sapiens
WIG001014
Genes involved in Negative regulation of FGFR signaling (more detail) 37 NA Homo sapiens
MEX001396
Genes associated with Kinase Inhibitor Gefitinib Genes associated with Kinase Inhibitor Gefitinib, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001956
Genes associated with Kinase Inhibitor 844499 71 4 Genes associated with Kinase Inhibitor 844499-71-4, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001537
Genes associated with Kinase Inhibitor NCGC00346967 01 Genes associated with Kinase Inhibitor NCGC00346967-01, curated by the Drug Signature Database (DSig (more detail) 22 25990557 Homo sapiens
MEX002410
Genes associated with Kinase Inhibitor Gefitinib Genes associated with Kinase Inhibitor Gefitinib, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001613
Genes associated with Kinase Inhibitor CHEMBL1241473 Genes associated with Kinase Inhibitor CHEMBL1241473, curated by the Drug Signature Database (DSigDB (more detail) 22 25990557 Homo sapiens
MEX001455
Genes associated with Kinase Inhibitor CHEMBL468963 Genes associated with Kinase Inhibitor CHEMBL468963, curated by the Drug Signature Database (DSigDB) (more detail) 22 25990557 Homo sapiens
MEX001859
Genes associated with Kinase Inhibitor 405169 16 6 Genes associated with Kinase Inhibitor 405169-16-6, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001434
Genes associated with Kinase Inhibitor Brivanib Genes associated with Kinase Inhibitor Brivanib, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001972
Genes associated with Kinase Inhibitor 722544 51 6 Genes associated with Kinase Inhibitor 722544-51-6, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001895
Genes associated with Kinase Inhibitor Motesanib Genes associated with Kinase Inhibitor Motesanib, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
FOX000621
Genes in the cancer module 303 (more detail) 28 NA Homo sapiens
FOX000543
Genes in the cancer module 210 (more detail) 28 NA Homo sapiens
TAX019306
GO:0016925 biological process protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target pro (more detail) 38 NA Homo sapiens
TAX021560
GO:0032451 molecular function demethylase activity Catalysis of the removal of a methyl group from a substrate. (more detail) 39 NA Homo sapiens
MEX002324
Genes associated with Kinase Inhibitor CHEMBL1967116 Genes associated with Kinase Inhibitor CHEMBL1967116, curated by the Drug Signature Database (DSigDB (more detail) 21 25990557 Homo sapiens
MEX001818
Genes associated with Kinase Inhibitor TPCA 1 Genes associated with Kinase Inhibitor TPCA-1, curated by the Drug Signature Database (DSigDB). (more detail) 21 25990557 Homo sapiens
TAX019268
GO:0016864 molecular function intramolecular oxidoreductase activity, transposing S S bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are th (more detail) 21 NA Homo sapiens
TAX015035
GO:0004198 molecular function calcium dependent cysteine type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using (more detail) 21 NA Homo sapiens
TAX015038
GO:0004298 molecular function threonine type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which (more detail) 21 NA Homo sapiens
TAX014788
GO:0003756 molecular function protein disulfide isomerase activity Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. (more detail) 21 NA Homo sapiens
MAX000760
Genes in the blue cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis (more detail) 21 NA Homo sapiens
MEX001652
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 21 25990557 Homo sapiens
MEX002120
Genes associated with Kinase Inhibitor GW559768X Genes associated with Kinase Inhibitor GW559768X, curated by the Drug Signature Database (DSigDB). (more detail) 21 25990557 Homo sapiens
TAX028680
GO:0070003 molecular function threonine type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydr (more detail) 21 NA Homo sapiens
MEX002394
Genes associated with Kinase Inhibitor TG100 115 Genes associated with Kinase Inhibitor TG100-115, curated by the Drug Signature Database (DSigDB). (more detail) 34 25990557 Homo sapiens
TAX022177
GO:0033619 biological process membrane protein proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or e (more detail) 37 NA Homo sapiens
MAX000764
Genes required for CTNNB1 [GeneID=1499] activity in DLD 1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen. Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancer (more detail) 32 NA Homo sapiens
MEX001882
Genes associated with Kinase Inhibitor 918505 84 7 Genes associated with Kinase Inhibitor 918505-84-7, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
MEX001726
Genes associated with Kinase Inhibitor GSK1007102B Genes associated with Kinase Inhibitor GSK1007102B, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
MEX001606
Genes associated with Kinase Inhibitor Lck Inhibitor Genes associated with Kinase Inhibitor Lck Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 20 25990557 Homo sapiens
MEX001585
Genes associated with Kinase Inhibitor NCGC00346963 01 Genes associated with Kinase Inhibitor NCGC00346963-01, curated by the Drug Signature Database (DSig (more detail) 20 25990557 Homo sapiens
MEX002422
Genes associated with Kinase Inhibitor Lenvatinib Genes associated with Kinase Inhibitor Lenvatinib, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
FEX001381
Leukemia Bradbury05 23genes RelatedProteinsMC TABLE S2 Expression of deacetylases and related proteins in mononuclear cells from 23 primary AML pa (more detail) 20 16121216 Homo sapiens
MEX001484
Genes associated with Kinase Inhibitor Kinome 511 Genes associated with Kinase Inhibitor Kinome_511, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
MEX001208
Genes associated with Kinase Inhibitor gw5074 Genes associated with Kinase Inhibitor gw5074, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
FEX001380
Leukemia Bradbury05 23genes AssociatedProteinsPMBC Table S1 Expression of deacetylases and associated proteins in peripheral blood mononuclear cells (P (more detail) 20 16121216 Homo sapiens
MEX002011
Genes associated with Kinase Inhibitor SB 203580 Genes associated with Kinase Inhibitor SB 203580, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
MEX001890
Genes associated with Kinase Inhibitor Kinome 1221 Genes associated with Kinase Inhibitor Kinome_1221, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
MEX001463
Genes associated with Kinase Inhibitor LDN193189 Genes associated with Kinase Inhibitor LDN193189, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
TAX001440
Genes annotated by the GO term GO:0019198. The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal dependent manner. (more detail) 19 NA Homo sapiens
TAX015295
GO:0004653 molecular function polypeptide N acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosami (more detail) 19 NA Homo sapiens
MEX002268
Genes associated with Kinase Inhibitor indirubin deriv. 7a Genes associated with Kinase Inhibitor indirubin deriv. 7a, curated by the Drug Signature Database ( (more detail) 19 25990557 Homo sapiens
MEX001303
Genes associated with Kinase Inhibitor Kinome 1198 Genes associated with Kinase Inhibitor Kinome_1198, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
TAX015544
GO:0005003 molecular function ephrin receptor activity Combining with an ephrin to initiate a change in cell activity. (more detail) 19 NA Homo sapiens
MEX002301
Genes associated with Kinase Inhibitor TCMDC 138201 Genes associated with Kinase Inhibitor TCMDC-138201, curated by the Drug Signature Database (DSigDB) (more detail) 19 25990557 Homo sapiens
MEX001386
Genes associated with Kinase Inhibitor Masitinib Genes associated with Kinase Inhibitor Masitinib, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
MEX001650
Genes associated with Kinase Inhibitor GNE 7915 Genes associated with Kinase Inhibitor GNE-7915, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
MOX015829
Genes associated with Computational Drug Signature Velcade(Bortezomib) Genes associated with Computational Drug Signature Velcade(Bortezomib), curated by the Drug Signatur (more detail) 35 25990557 Homo sapiens
MEX000819
Genes associated with Approved Drug bortezomib Genes associated with Approved Drug bortezomib, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
TAX019003
GO:0016409 molecular function palmitoyltransferase activity Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. (more detail) 38 NA Homo sapiens
WIG001028
Genes involved in NOD1/2 Signaling Pathway (more detail) 30 NA Homo sapiens
FOX000697
Genes in the cancer module 4 (more detail) 21 NA Homo sapiens
TAX019525
GO:0018345 biological process protein palmitoylation The covalent attachment of a palmitoyl group to a protein. (more detail) 28 NA Homo sapiens
TAX028983
GO:0070536 biological process protein K63 linked deubiquitination A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquiti (more detail) 28 NA Homo sapiens
WIG000850
Genes involved in FRS2 mediated cascade (more detail) 36 NA Homo sapiens
TAX023514
GO:0038128 biological process ERBB2 signaling pathway A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of rec (more detail) 31 NA Homo sapiens
FOX000840
Genes in the cancer module 82 (more detail) 24 NA Homo sapiens
MEX002326
Genes associated with Kinase Inhibitor Kinome 858 Genes associated with Kinase Inhibitor Kinome_858, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX002295
Genes associated with Kinase Inhibitor NVP TAE684 Genes associated with Kinase Inhibitor NVP-TAE684, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX002303
Genes associated with Kinase Inhibitor Kinome 1901 Genes associated with Kinase Inhibitor Kinome_1901, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX002032
Genes associated with Kinase Inhibitor Syk Inhibitor II Genes associated with Kinase Inhibitor Syk Inhibitor II, curated by the Drug Signature Database (DSi (more detail) 18 25990557 Homo sapiens
MEX001921
Genes associated with Kinase Inhibitor LRRK2 IN 1 Genes associated with Kinase Inhibitor LRRK2-IN-1, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
PEX002478
JmjC: JmjC domain, hydroxylase The JmjC domain belongs to the Cupin superfamily 3. JmjC-domain proteins may be protein hydroxylases (more detail) 18 NA Homo sapiens
MEX002201
Genes associated with Kinase Inhibitor 405554 55 4 Genes associated with Kinase Inhibitor 405554-55-4, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX001286
Genes associated with Kinase Inhibitor Syk Inhibitor Genes associated with Kinase Inhibitor Syk Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 18 25990557 Homo sapiens
MEX001999
Genes associated with Kinase Inhibitor Quizartinib Genes associated with Kinase Inhibitor Quizartinib, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX002234
Genes associated with Kinase Inhibitor czc 25146 Genes associated with Kinase Inhibitor czc-25146, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX002297
Genes associated with Kinase Inhibitor ( ) Epigallocatechin gallate Genes associated with Kinase Inhibitor (-)-Epigallocatechin gallate, curated by the Drug Signature D (more detail) 18 25990557 Homo sapiens
MEX002371
Genes associated with Kinase Inhibitor Kinome 454 Genes associated with Kinase Inhibitor Kinome_454, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
TAX022680
GO:0034979 molecular function NAD dependent protein deacetylase activity Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. (more detail) 18 NA Homo sapiens
PEX000769
SET: SET domain SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein i (more detail) 22 NA Homo sapiens
MOX007314
Genes associated with Computational Drug Signature bisindolylmaleimide i Genes associated with Computational Drug Signature bisindolylmaleimide i, curated by the Drug Signat (more detail) 27 25990557 Homo sapiens
TAX019469
GO:0018126 biological process protein hydroxylation The addition of a hydroxy group to a protein amino acid. (more detail) 25 NA Homo sapiens
TAX019048
GO:0016486 biological process peptide hormone processing The generation of a mature peptide hormone by posttranslational processing of a prohormone. (more detail) 33 NA Homo sapiens
TAX020843
GO:0031146 biological process SCF dependent proteasomal ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 23 NA Homo sapiens
TAX022751
GO:0035173 molecular function histone kinase activity Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-so (more detail) 17 NA Homo sapiens
TAX024026
GO:0042800 molecular function histone methyltransferase activity (H3 K4 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L (more detail) 17 NA Homo sapiens
MEX001909
Genes associated with Kinase Inhibitor gw8510 Genes associated with Kinase Inhibitor gw8510, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MEX002318
Genes associated with Kinase Inhibitor GW801372X Genes associated with Kinase Inhibitor GW801372X, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
TAX018821
GO:0016018 molecular function cyclosporin A binding Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains (more detail) 17 NA Homo sapiens
MEX001683
Genes associated with Kinase Inhibitor Kinome 452 Genes associated with Kinase Inhibitor Kinome_452, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MEX001852
Genes associated with Kinase Inhibitor PD166285 Genes associated with Kinase Inhibitor PD166285, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
TAX017218
GO:0008353 molecular function RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA (more detail) 17 NA Homo sapiens
MEX001699
Genes associated with Kinase Inhibitor GW806742X Genes associated with Kinase Inhibitor GW806742X, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MEX001654
Genes associated with Kinase Inhibitor CHEMBL2062936 Genes associated with Kinase Inhibitor CHEMBL2062936, curated by the Drug Signature Database (DSigDB (more detail) 17 25990557 Homo sapiens
MEX002171
Genes associated with Kinase Inhibitor PF 03814735 Genes associated with Kinase Inhibitor PF-03814735, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
TAX019197
GO:0016755 molecular function transferase activity, transferring amino acyl groups Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). (more detail) 17 NA Homo sapiens
MEX001560
Genes associated with Kinase Inhibitor TWS119 Genes associated with Kinase Inhibitor TWS119, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MOX007549
Genes associated with Computational Drug Signature Cdk9 Inhibitor II Genes associated with Computational Drug Signature Cdk9 Inhibitor II, curated by the Drug Signature (more detail) 21 25990557 Homo sapiens
MOX015246
Genes associated with Computational Drug Signature Sunitinib Genes associated with Computational Drug Signature Sunitinib, curated by the Drug Signature Database (more detail) 19 25990557 Homo sapiens
WIG001781
4 1BB Pathway 4-1BB Pathway (more detail) 31 NA Homo sapiens
WIG000580
O Glycan biosynthesis O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis (more detail) 26 NA Homo sapiens
IEI003821
Protein protein interactors of human gene DTX3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DTX3 (SwissProt ID=Q (more detail) 26 17535438 Homo sapiens
WIG001719
UVB Induced MAPK Signaling UVB-Induced MAPK Signaling (more detail) 29 NA Homo sapiens
FOX000560
Genes in the cancer module 233 (more detail) 22 NA Homo sapiens
WIG000841
Genes involved in FGFR ligand binding and activation (more detail) 22 NA Homo sapiens
MEX001440
Genes associated with Kinase Inhibitor Kinome 866 Genes associated with Kinase Inhibitor Kinome_866, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
MEX001336
Genes associated with Kinase Inhibitor Kinome 2010 Genes associated with Kinase Inhibitor Kinome_2010, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
MEX001830
Genes associated with Kinase Inhibitor CHEMBL463931 Genes associated with Kinase Inhibitor CHEMBL463931, curated by the Drug Signature Database (DSigDB) (more detail) 16 25990557 Homo sapiens
MEX001468
Genes associated with Kinase Inhibitor Kinome 1242 Genes associated with Kinase Inhibitor Kinome_1242, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
TAX019626
GO:0019198 molecular function transmembrane receptor protein phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 16 NA Homo sapiens
WIG000656
Genes involved in Activated point mutants of FGFR2 (more detail) 16 NA Homo sapiens
TAX015326
GO:0004697 molecular function protein kinase C activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylgl (more detail) 16 NA Homo sapiens
FEX001680
Leukemia Messina10 16genes Table 4. PK Genes Specifically Expressed in B-NEG Patients Versus at Least 2 Other Groups (more detail) 16 20564080 Homo sapiens
TAX019229
GO:0016805 molecular function dipeptidase activity Catalysis of the hydrolysis of a dipeptide. (more detail) 16 NA Homo sapiens
MEX001349
Genes associated with Kinase Inhibitor CHEMBL1982466 Genes associated with Kinase Inhibitor CHEMBL1982466, curated by the Drug Signature Database (DSigDB (more detail) 16 25990557 Homo sapiens
MEX002341
Genes associated with Kinase Inhibitor GW806290X Genes associated with Kinase Inhibitor GW806290X, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
MEX001310
Genes associated with Kinase Inhibitor Kinome 473 Genes associated with Kinase Inhibitor Kinome_473, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
TAX015543
GO:0005001 molecular function transmembrane receptor protein tyrosine phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 16 NA Homo sapiens
TAX015313
GO:0004675 molecular function transmembrane receptor protein serine/threonine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 16 NA Homo sapiens
FEX000581
Breast Finetti08 16genes Table 1. List of the 16 kinases from the gene cluster identified byquality threshold-clustering (more detail) 16 18245477 Homo sapiens
MEX001867
Genes associated with Kinase Inhibitor HG 9 91 01 Genes associated with Kinase Inhibitor HG-9-91-01, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
TAX019401
GO:0017136 molecular function NAD dependent histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This react (more detail) 16 NA Homo sapiens
MAX000762
Genes in the green cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis (more detail) 16 NA Homo sapiens
MAX000763
Genes in the red cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis (more detail) 16 NA Homo sapiens
TAX030707
GO:0097153 molecular function cysteine type endopeptidase activity involved in apoptotic process Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 16 NA Homo sapiens
TAX023177
GO:0035970 biological process peptidyl threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. (more detail) 16 NA Homo sapiens
TAX028683
GO:0070008 molecular function serine type exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus (more detail) 16 NA Homo sapiens
WIG001701
TNFR2 Pathway TNFR2 Pathway (more detail) 30 NA Homo sapiens
WIG001734
Mechanism of Anthrax Toxins Mechanism of Anthrax Toxins (more detail) 20 NA Homo sapiens
MEX001105
Genes associated with Approved Drug regorafenib Genes associated with Approved Drug regorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
TAX001049
Genes annotated by the GO term GO:0000151. A protein complex that includes a ubiquitin protein ligase (E3) and other proteins that may confer substrate specificity on the complex. (more detail) 25 NA Homo sapiens
WIG001202
Genes involved in Signaling by FGFR1 mutants (more detail) 28 NA Homo sapiens
WIG000136
p38 MAPK signaling pathway (more detail) 26 NA Homo sapiens
MOX013523
Genes associated with Computational Drug Signature LY 294002 Genes associated with Computational Drug Signature LY 294002, curated by the Drug Signature Database (more detail) 29 25990557 Homo sapiens
MOX005959
Genes associated with Computational Drug Signature 4,5,6,7 tetrabromobenzotriazole Genes associated with Computational Drug Signature 4,5,6,7-tetrabromobenzotriazole, curated by the D (more detail) 29 25990557 Homo sapiens
MEX001079
Genes associated with Approved Drug vargatef Genes associated with Approved Drug vargatef, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX002159
Genes associated with Kinase Inhibitor Kinome 6 Genes associated with Kinase Inhibitor Kinome_6, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
PEX001185
Proteasome: Proteasome subunit The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essenti (more detail) 15 NA Homo sapiens
MOX014298
Genes associated with Computational Drug Signature oxindole i Genes associated with Computational Drug Signature oxindole i, curated by the Drug Signature Databas (more detail) 15 25990557 Homo sapiens
MEX002164
Genes associated with Kinase Inhibitor GSK1220512A Genes associated with Kinase Inhibitor GSK1220512A, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX002180
Genes associated with Kinase Inhibitor Alsterpaullone, 2 Cyanoethyl Genes associated with Kinase Inhibitor Alsterpaullone, 2-Cyanoethyl, curated by the Drug Signature D (more detail) 15 25990557 Homo sapiens
FEX001389
Leukemia Chiaretti05 16genes Table 4. Kinase genes with high-level gene expression in samples without known molecular rearrangeme (more detail) 15 16243790 Homo sapiens
TAX017150
GO:0008242 molecular function omega peptidase activity Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by is (more detail) 15 NA Homo sapiens
MEX002132
Genes associated with Kinase Inhibitor CGP 60474 Genes associated with Kinase Inhibitor CGP 60474, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX001973
Genes associated with Kinase Inhibitor GSK429286A Genes associated with Kinase Inhibitor GSK429286A, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
TAX015334
GO:0004708 molecular function MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu (more detail) 15 NA Homo sapiens
MEX001388
Genes associated with Kinase Inhibitor Kinome 406 Genes associated with Kinase Inhibitor Kinome_406, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX001548
Genes associated with Kinase Inhibitor su6656 Genes associated with Kinase Inhibitor su6656, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX001966
Genes associated with Kinase Inhibitor CHEMBL1950303 Genes associated with Kinase Inhibitor CHEMBL1950303, curated by the Drug Signature Database (DSigDB (more detail) 15 25990557 Homo sapiens
MAX000761
Genes in the gray cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis (more detail) 15 NA Homo sapiens
MEX002345
Genes associated with Kinase Inhibitor bisindolylmaleimide i Genes associated with Kinase Inhibitor bisindolylmaleimide i, curated by the Drug Signature Database (more detail) 15 25990557 Homo sapiens
MEX001495
Genes associated with Kinase Inhibitor H 89 DIHYDROCHLORIDE Genes associated with Kinase Inhibitor H-89 DIHYDROCHLORIDE, curated by the Drug Signature Database (more detail) 15 25990557 Homo sapiens
TAX015963
GO:0005839 cellular component proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. (more detail) 19 NA Homo sapiens
MEX001914
Genes associated with Kinase Inhibitor 929095 18 1 Genes associated with Kinase Inhibitor 929095-18-1, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
WAG000206
O Glycan biosynthesis O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis (more detail) 24 NA Homo sapiens
MOX003346
Genes associated with Computational Drug Signature Tozasertib Genes associated with Computational Drug Signature Tozasertib, curated by the Drug Signature Databas (more detail) 24 25990557 Homo sapiens
MOX003517
Genes associated with Computational Drug Signature Carfilzomib Genes associated with Computational Drug Signature Carfilzomib, curated by the Drug Signature Databa (more detail) 27 25990557 Homo sapiens
MOX015586
Genes associated with Computational Drug Signature Tozasertib Genes associated with Computational Drug Signature Tozasertib, curated by the Drug Signature Databas (more detail) 22 25990557 Homo sapiens
IEI014615
Protein protein interactors of human gene UBOX5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBOX5 (SwissProt ID= (more detail) 20 17535438 Homo sapiens
MEX002361
Genes associated with Kinase Inhibitor CHEMBL495696 Genes associated with Kinase Inhibitor CHEMBL495696, curated by the Drug Signature Database (DSigDB) (more detail) 14 25990557 Homo sapiens
MEX001718
Genes associated with Kinase Inhibitor Kinome 450 Genes associated with Kinase Inhibitor Kinome_450, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002082
Genes associated with Kinase Inhibitor GW795493X Genes associated with Kinase Inhibitor GW795493X, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
TAX022133
GO:0033549 molecular function MAP kinase phosphatase activity Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. (more detail) 14 NA Homo sapiens
MEX002228
Genes associated with Kinase Inhibitor Kinome 3196 Genes associated with Kinase Inhibitor Kinome_3196, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX001207
Genes associated with Kinase Inhibitor Kinome 439 Genes associated with Kinase Inhibitor Kinome_439, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002412
Genes associated with Kinase Inhibitor Tofacitinib Genes associated with Kinase Inhibitor Tofacitinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX001318
Genes associated with Kinase Inhibitor Ibrutinib Genes associated with Kinase Inhibitor Ibrutinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002375
Genes associated with Kinase Inhibitor dorsomorphin Genes associated with Kinase Inhibitor dorsomorphin, curated by the Drug Signature Database (DSigDB) (more detail) 14 25990557 Homo sapiens
MEX001709
Genes associated with Kinase Inhibitor Kinome 1216 Genes associated with Kinase Inhibitor Kinome_1216, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002135
Genes associated with Kinase Inhibitor Bisindolylmaleimide XI, HCl Genes associated with Kinase Inhibitor Bisindolylmaleimide XI, HCl, curated by the Drug Signature Da (more detail) 14 25990557 Homo sapiens
PEX002210
Pro isomerase: Cyclophilin type peptidyl prolyl cis trans isomerase/CLD The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 (more detail) 14 NA Homo sapiens
MEX001964
Genes associated with Kinase Inhibitor Kinome 859 Genes associated with Kinase Inhibitor Kinome_859, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002015
Genes associated with Kinase Inhibitor BS 181 Genes associated with Kinase Inhibitor BS-181, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002419
Genes associated with Kinase Inhibitor Ibrutinib Genes associated with Kinase Inhibitor Ibrutinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX001731
Genes associated with Kinase Inhibitor TCMDC 141371 Genes associated with Kinase Inhibitor TCMDC-141371, curated by the Drug Signature Database (DSigDB) (more detail) 14 25990557 Homo sapiens
MEX002123
Genes associated with Kinase Inhibitor Fostamatinib Genes associated with Kinase Inhibitor Fostamatinib, curated by the Drug Signature Database (DSigDB) (more detail) 14 25990557 Homo sapiens
TAX026437
GO:0050321 molecular function tau protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. (more detail) 14 NA Homo sapiens
MEX002415
Genes associated with Kinase Inhibitor Ceritinib Genes associated with Kinase Inhibitor Ceritinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002083
Genes associated with Kinase Inhibitor Go 6976 Genes associated with Kinase Inhibitor Go 6976, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
WIG000838
Genes involved in FGFR1 ligand binding and activation (more detail) 14 NA Homo sapiens
MEX002204
Genes associated with Kinase Inhibitor curcumin Genes associated with Kinase Inhibitor curcumin, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002283
Genes associated with Kinase Inhibitor Kinome 708 Genes associated with Kinase Inhibitor Kinome_708, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
TAX021563
GO:0032454 molecular function histone demethylase activity (H3 K9 specific) Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = s (more detail) 14 NA Homo sapiens
TAX015333
GO:0004707 molecular function MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphoryla (more detail) 14 NA Homo sapiens
MEX001945
Genes associated with Kinase Inhibitor Kinome 239 Genes associated with Kinase Inhibitor Kinome_239, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002094
Genes associated with Kinase Inhibitor Tasocitinib Genes associated with Kinase Inhibitor Tasocitinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002269
Genes associated with Kinase Inhibitor 841290 80 0 Genes associated with Kinase Inhibitor 841290-80-0, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
FEX002584
Prostate Wang02 25genes Table 1 Candidate genes responsive to (-) epigallocatechin-3-gallate in human prostate cancer LNCaP (more detail) 23 12175522 Homo sapiens
TAX016381
GO:0006509 biological process membrane protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular do (more detail) 23 NA Homo sapiens
WIG001468
DNA Methylation and Transcriptional Repression DNA Methylation and Transcriptional Repression (more detail) 23 NA Homo sapiens
TAX030738
GO:0097194 biological process execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the a (more detail) 26 NA Homo sapiens
WIG000827
Genes involved in ERK/MAPK targets (more detail) 21 NA Homo sapiens
MOX007316
Genes associated with Computational Drug Signature bisindolylmaleimide IX Genes associated with Computational Drug Signature bisindolylmaleimide IX, curated by the Drug Signa (more detail) 21 25990557 Homo sapiens
MOX011953
Genes associated with Computational Drug Signature CI 1040 Genes associated with Computational Drug Signature CI-1040, curated by the Drug Signature Database ( (more detail) 24 25990557 Homo sapiens
WIG001035
Genes involved in Nuclear Events (kinase and transcription factor activation) (more detail) 24 NA Homo sapiens
IEI011206
Protein protein interactors of human gene RFFL from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RFFL (SwissProt ID=Q (more detail) 19 17535438 Homo sapiens
WIG000888
Genes involved in GRB2 events in ERBB2 signaling (more detail) 22 NA Homo sapiens
TAX030744
GO:0097200 molecular function cysteine type endopeptidase activity involved in execution phase of apoptosis Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 13 NA Homo sapiens
MEX002041
Genes associated with Kinase Inhibitor Kinome 506 Genes associated with Kinase Inhibitor Kinome_506, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
PEX001420
Pkinase C: Protein kinase C terminal domain (more detail) 13 NA Homo sapiens
MOX005545
Genes associated with Computational Drug Signature 1H Pyrrole 2,5 dione, 3,4 bis(4 methoxyphenyl) Genes associated with Computational Drug Signature 1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)-, (more detail) 13 25990557 Homo sapiens
MEX001488
Genes associated with Kinase Inhibitor GSK2213727A Genes associated with Kinase Inhibitor GSK2213727A, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MEX001397
Genes associated with Kinase Inhibitor AGN PC 04WTVX Genes associated with Kinase Inhibitor AGN-PC-04WTVX, curated by the Drug Signature Database (DSigDB (more detail) 13 25990557 Homo sapiens
TAX019450
GO:0018027 biological process peptidyl lysine dimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. (more detail) 13 NA Homo sapiens
TAX019337
GO:0017017 molecular function MAP kinase tyrosine/serine/threonine phosphatase activity Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/ (more detail) 13 NA Homo sapiens
TAX001333
Genes annotated by the GO term GO:0008276. Catalysis of the transfer of a methyl group (CH3 ) to a protein. (more detail) 13 NA Homo sapiens
MEX002141
Genes associated with Kinase Inhibitor roscovitine Genes associated with Kinase Inhibitor roscovitine, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
TAX001076
Genes annotated by the GO term GO:0004177. Catalysis of the hydrolysis of N terminal amino acid residues from oligopeptides or polypeptides. (more detail) 13 NA Homo sapiens
FOX000769
Genes in the cancer module 50 (more detail) 13 NA Homo sapiens
MEX002319
Genes associated with Kinase Inhibitor Kinome 491 Genes associated with Kinase Inhibitor Kinome_491, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MEX001688
Genes associated with Kinase Inhibitor GW575808A Genes associated with Kinase Inhibitor GW575808A, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MOX005546
Genes associated with Computational Drug Signature 1H Pyrrole 2,5 dione, 3,4 diphenyl Genes associated with Computational Drug Signature 1H-Pyrrole-2,5-dione, 3,4-diphenyl-, curated by t (more detail) 13 25990557 Homo sapiens
MOX006679
Genes associated with Computational Drug Signature AGN PC 00BUNE Genes associated with Computational Drug Signature AGN-PC-00BUNE, curated by the Drug Signature Data (more detail) 13 25990557 Homo sapiens
TAX017147
GO:0008239 molecular function dipeptidyl peptidase activity Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. (more detail) 13 NA Homo sapiens
MEX002215
Genes associated with Kinase Inhibitor resveratrol Genes associated with Kinase Inhibitor resveratrol, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MOX015215
Genes associated with Computational Drug Signature SU11652 Genes associated with Computational Drug Signature SU11652, curated by the Drug Signature Database ( (more detail) 13 25990557 Homo sapiens
MEX001844
Genes associated with Kinase Inhibitor CHEMBL1999931 Genes associated with Kinase Inhibitor CHEMBL1999931, curated by the Drug Signature Database (DSigDB (more detail) 13 25990557 Homo sapiens
MEX001504
Genes associated with Kinase Inhibitor PKCbeta Inhibitor Genes associated with Kinase Inhibitor PKCbeta Inhibitor, curated by the Drug Signature Database (DS (more detail) 13 25990557 Homo sapiens
TAX021044
GO:0031543 molecular function peptidyl proline dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + s (more detail) 13 NA Homo sapiens
MEX002003
Genes associated with Kinase Inhibitor Kinome 474 Genes associated with Kinase Inhibitor Kinome_474, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
TAX034223
GO:1990380 molecular function Lys48 specific deubiquitinase activity Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. (more detail) 13 NA Homo sapiens
TAX022498
GO:0034450 molecular function ubiquitin ubiquitin ligase activity Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction (more detail) 13 NA Homo sapiens
TAX015790
GO:0005527 molecular function macrolide binding Interacting selectively and non-covalently with a macrolide, any of a large group of structurally re (more detail) 15 NA Homo sapiens
WAG000664
Regulation of p38 alpha and p38 beta (more detail) 15 NA Homo sapiens
TAX015791
GO:0005528 molecular function FK506 binding Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. (more detail) 15 NA Homo sapiens
TAX022014
GO:0033169 biological process histone H3 K9 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the his (more detail) 15 NA Homo sapiens
FEX003369
Viral Sun01 27genes Apoptosis Related TABLE 2. Expression Profile of Apoptosis-Related Genes in BC-2 Cells and Its Effect by MAP30 (more detail) 25 11573962 Homo sapiens
MOX013298
Genes associated with Computational Drug Signature KN 62 Genes associated with Computational Drug Signature KN-62, curated by the Drug Signature Database (DS (more detail) 18 25990557 Homo sapiens
FOX000805
Genes in the cancer module 562 (more detail) 21 NA Homo sapiens
PEX001246
UCH: Ubiquitin carboxyl terminal hydrolase (more detail) 12 NA Homo sapiens
MEX001610
Genes associated with Kinase Inhibitor CHEMBL1965660 Genes associated with Kinase Inhibitor CHEMBL1965660, curated by the Drug Signature Database (DSigDB (more detail) 12 25990557 Homo sapiens
MEX001775
Genes associated with Kinase Inhibitor Kinome 3513 Genes associated with Kinase Inhibitor Kinome_3513, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001806
Genes associated with Kinase Inhibitor Vandetanib Genes associated with Kinase Inhibitor Vandetanib, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001427
Genes associated with Kinase Inhibitor GSK1326255A Genes associated with Kinase Inhibitor GSK1326255A, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001323
Genes associated with Kinase Inhibitor Tyrphostin AG 1478 Genes associated with Kinase Inhibitor Tyrphostin AG 1478, curated by the Drug Signature Database (D (more detail) 12 25990557 Homo sapiens
TAX001240
Genes annotated by the GO term GO:0004707. Catalysis of the phosphorylation of proteins. Mitogen activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation or differentiation inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. (more detail) 12 NA Homo sapiens
MEX001913
Genes associated with Kinase Inhibitor Purvalanol B Genes associated with Kinase Inhibitor Purvalanol B, curated by the Drug Signature Database (DSigDB) (more detail) 12 25990557 Homo sapiens
TAX018950
GO:0016273 molecular function arginine N methyltransferase activity Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine (more detail) 12 NA Homo sapiens
MEX001816
Genes associated with Kinase Inhibitor Kinome 490 Genes associated with Kinase Inhibitor Kinome_490, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001992
Genes associated with Kinase Inhibitor bisindolylmaleimide i Genes associated with Kinase Inhibitor bisindolylmaleimide i, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
PEX000754
Peptidase M10: Matrixin The members of this family are enzymes that cleave peptides. These proteases require zinc for cataly (more detail) 12 NA Homo sapiens
TAX015032
GO:0004185 molecular function serine type carboxypeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a (more detail) 12 NA Homo sapiens
TAX018951
GO:0016274 molecular function protein arginine N methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine (more detail) 12 NA Homo sapiens
FEX001162
Immune Kong10 12genes ImmPort TGF betaFamilyMemberReceptors ImmPort genelist of cytokine receptors: TGF-beta Family Member Receptors (more detail) 12 20460173 Homo sapiens
MEX001329
Genes associated with Kinase Inhibitor Afatinib Genes associated with Kinase Inhibitor Afatinib, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001944
Genes associated with Kinase Inhibitor GSK1173862A Genes associated with Kinase Inhibitor GSK1173862A, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX002294
Genes associated with Kinase Inhibitor PYRAZOLOPYRIDAZINE 1 Genes associated with Kinase Inhibitor PYRAZOLOPYRIDAZINE 1, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
TAX018169
GO:0010857 molecular function calcium dependent protein kinase activity Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the pres (more detail) 12 NA Homo sapiens
MEX001644
Genes associated with Kinase Inhibitor 172889 27 9 Genes associated with Kinase Inhibitor 172889-27-9, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX002340
Genes associated with Kinase Inhibitor Kinome 10 Genes associated with Kinase Inhibitor Kinome_10, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX002002
Genes associated with Kinase Inhibitor Aurora Kinase/Cdk Inhibitor Genes associated with Kinase Inhibitor Aurora Kinase/Cdk Inhibitor, curated by the Drug Signature Da (more detail) 12 25990557 Homo sapiens
TAX001244
Genes annotated by the GO term GO:0008235. Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. (more detail) 12 NA Homo sapiens
MEX001423
Genes associated with Kinase Inhibitor Kinome 249 Genes associated with Kinase Inhibitor Kinome_249, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001634
Genes associated with Kinase Inhibitor Tandutinib Genes associated with Kinase Inhibitor Tandutinib, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001510
Genes associated with Kinase Inhibitor go 6983 Genes associated with Kinase Inhibitor go 6983, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
WIG000839
Genes involved in FGFR2c ligand binding and activation (more detail) 12 NA Homo sapiens
MEX001933
Genes associated with Kinase Inhibitor rottlerin Genes associated with Kinase Inhibitor rottlerin, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX002367
Genes associated with Kinase Inhibitor Kinome 501 Genes associated with Kinase Inhibitor Kinome_501, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001931
Genes associated with Kinase Inhibitor GW305178X Genes associated with Kinase Inhibitor GW305178X, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX002408
Genes associated with Kinase Inhibitor Afatinib Genes associated with Kinase Inhibitor Afatinib, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001209
Genes associated with Kinase Inhibitor 172889 26 8 Genes associated with Kinase Inhibitor 172889-26-8, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
TAX022775
GO:0035246 biological process peptidyl arginine N methylation The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein. (more detail) 12 NA Homo sapiens
MEX001428
Genes associated with Kinase Inhibitor Imatinib Genes associated with Kinase Inhibitor Imatinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MOX007338
Genes associated with Computational Drug Signature BMS 536924 Genes associated with Computational Drug Signature BMS-536924, curated by the Drug Signature Databas (more detail) 14 25990557 Homo sapiens
MEX002411
Genes associated with Kinase Inhibitor Imatinib Genes associated with Kinase Inhibitor Imatinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
TAX019741
GO:0019511 biological process peptidyl proline hydroxylation The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. (more detail) 14 NA Homo sapiens
MOX010842
Genes associated with Computational Drug Signature CHEMBL475540 Genes associated with Computational Drug Signature CHEMBL475540, curated by the Drug Signature Datab (more detail) 14 25990557 Homo sapiens
TAX019104
GO:0016578 biological process histone deubiquitination The modification of histones by removal of ubiquitin groups. (more detail) 22 NA Homo sapiens
IEI011407
Protein protein interactors of human gene RNF166 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF166 (SwissProt ID (more detail) 17 17535438 Homo sapiens
IEI014251
Protein protein interactors of human gene TRIM46 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM46 (SwissProt ID (more detail) 17 17535438 Homo sapiens
WAG000661
p38 MAPK signaling pathway (more detail) 17 NA Homo sapiens
TAX020902
GO:0031293 biological process membrane protein intracellular domain proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domai (more detail) 20 NA Homo sapiens
TAX000910
Genes annotated by the GO term GO:0000118. Complex that possesses histone deacetylase activity. (more detail) 20 NA Homo sapiens
TAX029192
GO:0070932 biological process histone H3 deacetylation The modification of histone H3 by the removal of one or more acetyl groups. (more detail) 20 NA Homo sapiens
WIG000779
Genes involved in Cyclin A/B1 associated events during G2/M transition (more detail) 15 NA Homo sapiens
IEI003380
Protein protein interactors of human gene DCUN1D5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DCUN1D5 (SwissProt I (more detail) 15 17535438 Homo sapiens
TAX028492
GO:0061578 molecular function Lys63 specific deubiquitinase activity Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. (more detail) 11 NA Homo sapiens
MEX001687
Genes associated with Kinase Inhibitor Saracatinib Genes associated with Kinase Inhibitor Saracatinib, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX001203
Genes associated with Kinase Inhibitor Cdk2 Inhibitor IV, NU6140 Genes associated with Kinase Inhibitor Cdk2 Inhibitor IV, NU6140, curated by the Drug Signature Data (more detail) 11 25990557 Homo sapiens
WIG001194
Genes involved in Signaling by activated point mutants of FGFR1 (more detail) 11 NA Homo sapiens
MEX001255
Genes associated with Kinase Inhibitor Kinome 1199 Genes associated with Kinase Inhibitor Kinome_1199, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
TAX021301
GO:0032041 molecular function NAD dependent histone deacetylase activity (H3 K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine ( (more detail) 11 NA Homo sapiens
TAX017216
GO:0008349 molecular function MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kin (more detail) 11 NA Homo sapiens
TAX001108
Genes annotated by the GO term GO:0004180. Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C terminal end of a peptide or polypeptide. (more detail) 11 NA Homo sapiens
TAX017810
GO:0009931 molecular function calcium dependent protein serine/threonine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a pro (more detail) 11 NA Homo sapiens
TAX019803
GO:0019774 cellular component proteasome core complex, beta subunit complex The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. (more detail) 11 NA Homo sapiens
MEX001348
Genes associated with Kinase Inhibitor GW589933X Genes associated with Kinase Inhibitor GW589933X, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX001639
Genes associated with Kinase Inhibitor Ruboxistaurin Genes associated with Kinase Inhibitor Ruboxistaurin, curated by the Drug Signature Database (DSigDB (more detail) 11 25990557 Homo sapiens
MEX001836
Genes associated with Kinase Inhibitor CHEMBL456252 Genes associated with Kinase Inhibitor CHEMBL456252, curated by the Drug Signature Database (DSigDB) (more detail) 11 25990557 Homo sapiens
MOX014978
Genes associated with Computational Drug Signature Saracatinib Genes associated with Computational Drug Signature Saracatinib, curated by the Drug Signature Databa (more detail) 11 25990557 Homo sapiens
TAX000560
Genes annotated by the GO term GO:0000209. Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain. (more detail) 11 NA Homo sapiens
MEX001269
Genes associated with Kinase Inhibitor A 443654 Genes associated with Kinase Inhibitor A-443654, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX002305
Genes associated with Kinase Inhibitor Kinome 248 Genes associated with Kinase Inhibitor Kinome_248, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX002211
Genes associated with Kinase Inhibitor Kinome 812 Genes associated with Kinase Inhibitor Kinome_812, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX002233
Genes associated with Kinase Inhibitor CHEMBL1969102 Genes associated with Kinase Inhibitor CHEMBL1969102, curated by the Drug Signature Database (DSigDB (more detail) 11 25990557 Homo sapiens
MEX001674
Genes associated with Kinase Inhibitor InSolution¿¿KT5720 Genes associated with Kinase Inhibitor InSolution¿¿KT5720, curated by the Drug Signa (more detail) 11 25990557 Homo sapiens
MOX009947
Genes associated with Computational Drug Signature CHEMBL380598 Genes associated with Computational Drug Signature CHEMBL380598, curated by the Drug Signature Datab (more detail) 11 25990557 Homo sapiens
MOX012940
Genes associated with Computational Drug Signature GSK690693 Genes associated with Computational Drug Signature GSK690693, curated by the Drug Signature Database (more detail) 11 25990557 Homo sapiens
WIG001203
Genes involved in Signaling by FGFR3 mutants (more detail) 11 NA Homo sapiens
WIG000434
Activation of Src by Protein tyrosine phosphatase alpha Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a prote (more detail) 11 NA Homo sapiens
MEX001244
Genes associated with Kinase Inhibitor 761437 28 9 Genes associated with Kinase Inhibitor 761437-28-9, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX001927
Genes associated with Kinase Inhibitor Kinome 528 Genes associated with Kinase Inhibitor Kinome_528, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX001625
Genes associated with Kinase Inhibitor PDK1/Akt/Flt Dual Pathway Inhibitor Genes associated with Kinase Inhibitor PDK1/Akt/Flt Dual Pathway Inhibitor, curated by the Drug Sign (more detail) 11 25990557 Homo sapiens
MEX001817
Genes associated with Kinase Inhibitor alsterpaullone Genes associated with Kinase Inhibitor alsterpaullone, curated by the Drug Signature Database (DSigD (more detail) 11 25990557 Homo sapiens
MEX001820
Genes associated with Kinase Inhibitor CHEMBL1970317 Genes associated with Kinase Inhibitor CHEMBL1970317, curated by the Drug Signature Database (DSigDB (more detail) 11 25990557 Homo sapiens
TAX020794
GO:0031078 molecular function histone deacetylase activity (H3 K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine ( (more detail) 11 NA Homo sapiens
WIG000931
Genes involved in Initial triggering of complement (more detail) 13 NA Homo sapiens
WIG000293
Complement Pathway The complement pathway consists of a series of over thirty proteins in plasma that are part of the i (more detail) 19 NA Homo sapiens
IEI005115
Protein protein interactors of human gene GCM1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GCM1 (SwissProt ID=Q (more detail) 14 17535438 Homo sapiens
IEI001350
Protein protein interactors of human gene BIRC8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene BIRC8 (SwissProt ID= (more detail) 14 17535438 Homo sapiens
TAX019085
GO:0016540 biological process protein autoprocessing Processing which a protein carries out itself. This involves actions such as the autolytic removal o (more detail) 14 NA Homo sapiens
MOX012907
Genes associated with Computational Drug Signature Go 6976 Genes associated with Computational Drug Signature Go 6976, curated by the Drug Signature Database ( (more detail) 12 25990557 Homo sapiens
MOX014858
Genes associated with Computational Drug Signature Ro 4396686 Genes associated with Computational Drug Signature Ro-4396686, curated by the Drug Signature Databas (more detail) 12 25990557 Homo sapiens
WIG000840
Genes involved in FGFR4 ligand binding and activation (more detail) 12 NA Homo sapiens
WIG000826
Genes involved in ERKs are inactivated (more detail) 12 NA Homo sapiens
IEI014170
Protein protein interactors of human gene TRAF7 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRAF7 (SwissProt ID= (more detail) 12 17535438 Homo sapiens
TAX017292
GO:0008474 molecular function palmitoyl (protein) hydrolase activity Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. (more detail) 10 NA Homo sapiens
MEX001919
Genes associated with Kinase Inhibitor BMS 345541 free base Genes associated with Kinase Inhibitor BMS-345541 free base, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MEX000910
Genes associated with Approved Drug telaprevir Genes associated with Approved Drug telaprevir, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX001737
Genes associated with Kinase Inhibitor GW612286X Genes associated with Kinase Inhibitor GW612286X, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX001700
Genes associated with Kinase Inhibitor PD 173074 Genes associated with Kinase Inhibitor PD 173074, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX001743
Genes associated with Kinase Inhibitor CHEMBL1956068 Genes associated with Kinase Inhibitor CHEMBL1956068, curated by the Drug Signature Database (DSigDB (more detail) 10 25990557 Homo sapiens
MEX002168
Genes associated with Kinase Inhibitor GW782612X Genes associated with Kinase Inhibitor GW782612X, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX002334
Genes associated with Kinase Inhibitor Nilotinib Genes associated with Kinase Inhibitor Nilotinib, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX002193
Genes associated with Kinase Inhibitor Kinome 1218 Genes associated with Kinase Inhibitor Kinome_1218, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MOX014383
Genes associated with Computational Drug Signature PD 0173956 Genes associated with Computational Drug Signature PD-0173956, curated by the Drug Signature Databas (more detail) 10 25990557 Homo sapiens
TAX001324
Genes annotated by the GO term GO:0033558. Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. (more detail) 10 NA Homo sapiens
MEX001588
Genes associated with Kinase Inhibitor AG F 35231 Genes associated with Kinase Inhibitor AG-F-35231, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX002245
Genes associated with Kinase Inhibitor Kinome 192 Genes associated with Kinase Inhibitor Kinome_192, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX002390
Genes associated with Kinase Inhibitor CHEMBL212299 Genes associated with Kinase Inhibitor CHEMBL212299, curated by the Drug Signature Database (DSigDB) (more detail) 10 25990557 Homo sapiens
MOX008993
Genes associated with Computational Drug Signature CHEMBL230686 Genes associated with Computational Drug Signature CHEMBL230686, curated by the Drug Signature Datab (more detail) 10 25990557 Homo sapiens
PEX001303
Cyclin N: Cyclin, N terminal domain Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is r (more detail) 10 NA Homo sapiens
MEX001313
Genes associated with Kinase Inhibitor GSK2220400A Genes associated with Kinase Inhibitor GSK2220400A, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MOX014394
Genes associated with Computational Drug Signature PD166326 Genes associated with Computational Drug Signature PD166326, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
TAX019449
GO:0018026 biological process peptidyl lysine monomethylation The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. (more detail) 10 NA Homo sapiens
TAX001188
Genes annotated by the GO term GO:0042054. Catalysis of the transfer of a methyl group (CH3 ) to a histone. (more detail) 10 NA Homo sapiens
MEX001222
Genes associated with Kinase Inhibitor GSK 3 Inhibitor XIII Genes associated with Kinase Inhibitor GSK-3 Inhibitor XIII, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MEX001641
Genes associated with Kinase Inhibitor 1 [4 (4 Aminothieno[2,3 D]pyrimidin 5 Yl)phenyl] 3 [2 Fluoro 5 (Trifluoromethyl)phenyl]urea Genes associated with Kinase Inhibitor 1-[4-(4-Aminothieno[2,3-D]pyrimidin-5-Yl)phenyl]-3-[2-Fluoro- (more detail) 10 25990557 Homo sapiens
MEX001679
Genes associated with Kinase Inhibitor Kinome 504 Genes associated with Kinase Inhibitor Kinome_504, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX002075
Genes associated with Kinase Inhibitor 1 [4 (4 aminothieno[2,3 d]pyrimidin 5 yl)phenyl] 3 (3 methylphenyl)urea Genes associated with Kinase Inhibitor 1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylp (more detail) 10 25990557 Homo sapiens
MEX001630
Genes associated with Kinase Inhibitor Kinome 2812 Genes associated with Kinase Inhibitor Kinome_2812, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX001900
Genes associated with Kinase Inhibitor BMS 345541 free base Genes associated with Kinase Inhibitor BMS-345541 free base, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
TAX031099
GO:0098734 biological process macromolecule depalmitoylation The removal of palymitoyl groups from a macromolecule. (more detail) 10 NA Homo sapiens
TAX023130
GO:0035871 biological process protein K11 linked deubiquitination A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquiti (more detail) 10 NA Homo sapiens
TAX027223
GO:0051864 molecular function histone demethylase activity (H3 K36 specific) Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = (more detail) 10 NA Homo sapiens
IEI008506
Protein protein interactors of human gene MYT1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MYT1 (SwissProt ID=Q (more detail) 10 17535438 Homo sapiens
TAX031043
GO:0098599 molecular function palmitoyl hydrolase activity Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate. (more detail) 10 NA Homo sapiens
TAX022776
GO:0035247 biological process peptidyl arginine omega N methylation The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue (more detail) 10 NA Homo sapiens
TAX028990
GO:0070544 biological process histone H3 K36 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the hi (more detail) 10 NA Homo sapiens
FEX001589
Leukemia Sanchez Guijo08 19genes SuppTable2o Genes involved in protein phosphorilation (more detail) 17 18722011 Homo sapiens
WAG000992
Renin angiotensin system (more detail) 17 NA Homo sapiens
MOX014380
Genes associated with Computational Drug Signature PD 173074 Genes associated with Computational Drug Signature PD 173074, curated by the Drug Signature Database (more detail) 17 25990557 Homo sapiens
WIG000609
Renin angiotensin system (more detail) 17 NA Homo sapiens
MOX003478
Genes associated with Computational Drug Signature NVP TAE684 Genes associated with Computational Drug Signature NVP-TAE684, curated by the Drug Signature Databas (more detail) 17 25990557 Homo sapiens
IEI010346
Protein protein interactors of human gene PPP1R14A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PPP1R14A (SwissProt (more detail) 17 17535438 Homo sapiens
IEI015826
Protein protein interactors of human gene ZNRF1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ZNRF1 (SwissProt ID= (more detail) 17 17535438 Homo sapiens
TAX023476
GO:0038061 biological process NIK/NF kappaB signaling The process in which a signal is passed on to downstream components within the cell through the NIK- (more detail) 17 NA Homo sapiens
WIG000059
ErbB receptor signaling network (more detail) 15 NA Homo sapiens
WIG001131
Genes involved in Regulation of AMPK activity via LKB1 (more detail) 15 NA Homo sapiens
IEI011434
Protein protein interactors of human gene RNF25 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF25 (SwissProt ID= (more detail) 15 17535438 Homo sapiens
MOX007591
Genes associated with Computational Drug Signature CGS 27023A Genes associated with Computational Drug Signature CGS-27023A, curated by the Drug Signature Databas (more detail) 13 25990557 Homo sapiens
IEI014257
Protein protein interactors of human gene TRIM50 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM50 (SwissProt ID (more detail) 13 17535438 Homo sapiens
TAX001147
Genes annotated by the GO term GO:0008144. Interacting selectively with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. (more detail) 16 NA Homo sapiens
MOX003367
Genes associated with Computational Drug Signature Lapatinib Genes associated with Computational Drug Signature Lapatinib, curated by the Drug Signature Database (more detail) 16 25990557 Homo sapiens
TAX019500
GO:0018216 biological process peptidyl arginine methylation The addition of a methyl group to an arginine residue in a protein. (more detail) 16 NA Homo sapiens
IEI003055
Protein protein interactors of human gene CSN1S1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CSN1S1 (SwissProt ID (more detail) 16 17535438 Homo sapiens
TAX016350
GO:0006465 biological process signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific l (more detail) 11 NA Homo sapiens
TAX013995
GO:0002003 biological process angiotensin maturation The process leading to the attainment of the full functional capacity of angiotensin by conversion o (more detail) 11 NA Homo sapiens
TAX001135
Genes annotated by the GO term GO:0019213. Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. (more detail) 11 NA Homo sapiens
FOX000544
Genes in the cancer module 211 (more detail) 11 NA Homo sapiens
TAX001266
Genes annotated by the GO term GO:0004715. Catalysis of the reaction: ATP + a protein L tyrosine = ADP + a protein L tyrosine phosphate. (more detail) 11 NA Homo sapiens
MEX001433
Genes associated with Kinase Inhibitor S1107 Selleck Genes associated with Kinase Inhibitor S1107_Selleck, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MEX001374
Genes associated with Kinase Inhibitor CHEMBL411903 Genes associated with Kinase Inhibitor CHEMBL411903, curated by the Drug Signature Database (DSigDB) (more detail) 9 25990557 Homo sapiens
MEX002078
Genes associated with Kinase Inhibitor Kinome 2052 Genes associated with Kinase Inhibitor Kinome_2052, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002191
Genes associated with Kinase Inhibitor CHEMBL241517 Genes associated with Kinase Inhibitor CHEMBL241517, curated by the Drug Signature Database (DSigDB) (more detail) 9 25990557 Homo sapiens
PEX002570
zf RING 2: Ring finger domain (more detail) 9 NA Homo sapiens
MEX001377
Genes associated with Kinase Inhibitor Kinome 468 Genes associated with Kinase Inhibitor Kinome_468, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001398
Genes associated with Kinase Inhibitor JNK Inhibitor V Genes associated with Kinase Inhibitor JNK Inhibitor V, curated by the Drug Signature Database (DSig (more detail) 9 25990557 Homo sapiens
MEX001289
Genes associated with Kinase Inhibitor SU11274 Genes associated with Kinase Inhibitor SU11274, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001380
Genes associated with Kinase Inhibitor lfm a13 Genes associated with Kinase Inhibitor lfm-a13, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002147
Genes associated with Kinase Inhibitor CHEMBL1979883 Genes associated with Kinase Inhibitor CHEMBL1979883, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MEX002183
Genes associated with Kinase Inhibitor PDGF Receptor Tyrosine Kinase Inhibitor V Genes associated with Kinase Inhibitor PDGF Receptor Tyrosine Kinase Inhibitor V, curated by the Dru (more detail) 9 25990557 Homo sapiens
MEX001211
Genes associated with Kinase Inhibitor purvalanol A Genes associated with Kinase Inhibitor purvalanol A, curated by the Drug Signature Database (DSigDB) (more detail) 9 25990557 Homo sapiens
PEX001977
Peptidase C14: Caspase domain (more detail) 9 NA Homo sapiens
WAG000332
mRNA Processing (more detail) 9 NA Homo sapiens
MEX001260
Genes associated with Kinase Inhibitor Sunitinib Genes associated with Kinase Inhibitor Sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001049
Genes associated with Approved Drug sunitinib malate Genes associated with Approved Drug sunitinib malate, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MEX002000
Genes associated with Kinase Inhibitor CHEMBL1993941 Genes associated with Kinase Inhibitor CHEMBL1993941, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MOX007345
Genes associated with Computational Drug Signature BMS 754807 Genes associated with Computational Drug Signature BMS-754807, curated by the Drug Signature Databas (more detail) 9 25990557 Homo sapiens
TAX014794
GO:0003810 molecular function protein glutamine gamma glutamyltransferase activity Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This re (more detail) 9 NA Homo sapiens
TAX015321
GO:0004690 molecular function cyclic nucleotide dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the pres (more detail) 9 NA Homo sapiens
PEX001840
EphA2 TM: Ephrin type A receptor 2 transmembrane domain Epha2_TM represents the left-handed dimer transmembrane domain of of EphA2 receptor. This domain ol (more detail) 9 NA Homo sapiens
MEX001372
Genes associated with Kinase Inhibitor Kinome 1335 Genes associated with Kinase Inhibitor Kinome_1335, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001354
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001911
Genes associated with Kinase Inhibitor ML 9 Genes associated with Kinase Inhibitor ML-9, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001691
Genes associated with Kinase Inhibitor Kinome 413 Genes associated with Kinase Inhibitor Kinome_413, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002119
Genes associated with Kinase Inhibitor GW809897X Genes associated with Kinase Inhibitor GW809897X, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
TAX021046
GO:0031545 molecular function peptidyl proline 4 dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-pro (more detail) 9 NA Homo sapiens
MEX001071
Genes associated with Approved Drug belinostat Genes associated with Approved Drug belinostat, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001887
Genes associated with Kinase Inhibitor aminopurvalanol A Genes associated with Kinase Inhibitor aminopurvalanol A, curated by the Drug Signature Database (DS (more detail) 9 25990557 Homo sapiens
MEX001563
Genes associated with Kinase Inhibitor Kinome 2079 Genes associated with Kinase Inhibitor Kinome_2079, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002033
Genes associated with Kinase Inhibitor Sorafenib Genes associated with Kinase Inhibitor Sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002068
Genes associated with Kinase Inhibitor BX 320 Genes associated with Kinase Inhibitor BX-320, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001793
Genes associated with Kinase Inhibitor CHEMBL1979577 Genes associated with Kinase Inhibitor CHEMBL1979577, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MOX013420
Genes associated with Computational Drug Signature leucettamine B Genes associated with Computational Drug Signature leucettamine B, curated by the Drug Signature Dat (more detail) 9 25990557 Homo sapiens
TAX014054
GO:0002084 biological process protein depalmitoylation The removal of palymitoyl groups from a lipoprotein. (more detail) 9 NA Homo sapiens
TAX020953
GO:0031371 cellular component ubiquitin conjugating enzyme complex Any complex that possesses ubiquitin conjugating enzyme activity. (more detail) 9 NA Homo sapiens
TAX015558
GO:0005024 molecular function transforming growth factor beta activated receptor activity Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side (more detail) 9 NA Homo sapiens
MOX012197
Genes associated with Computational Drug Signature Debromohymenialdisine Genes associated with Computational Drug Signature Debromohymenialdisine, curated by the Drug Signat (more detail) 9 25990557 Homo sapiens
TAX001241
Genes annotated by the GO term GO:0004709. Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. (more detail) 9 NA Homo sapiens
MEX001449
Genes associated with Kinase Inhibitor CHEMBL47203 Genes associated with Kinase Inhibitor CHEMBL47203, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001403
Genes associated with Kinase Inhibitor NCGC00346961 01 Genes associated with Kinase Inhibitor NCGC00346961-01, curated by the Drug Signature Database (DSig (more detail) 9 25990557 Homo sapiens
MEX001253
Genes associated with Kinase Inhibitor Kinome 242 Genes associated with Kinase Inhibitor Kinome_242, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002310
Genes associated with Kinase Inhibitor Tozasertib Genes associated with Kinase Inhibitor Tozasertib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002218
Genes associated with Kinase Inhibitor BX 517 Genes associated with Kinase Inhibitor BX-517, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001901
Genes associated with Kinase Inhibitor Kinome 709 Genes associated with Kinase Inhibitor Kinome_709, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002231
Genes associated with Kinase Inhibitor 1 NM PP1 Genes associated with Kinase Inhibitor 1-NM-PP1, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001682
Genes associated with Kinase Inhibitor 7 Hydroxystaurosporine Genes associated with Kinase Inhibitor 7-Hydroxystaurosporine, curated by the Drug Signature Databas (more detail) 9 25990557 Homo sapiens
MEX002104
Genes associated with Kinase Inhibitor PF 477736 Genes associated with Kinase Inhibitor PF-477736, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002121
Genes associated with Kinase Inhibitor CHEMBL2062937 Genes associated with Kinase Inhibitor CHEMBL2062937, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MEX001823
Genes associated with Kinase Inhibitor GW843682X Genes associated with Kinase Inhibitor GW843682X, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
PEX001660
HECT: HECT domain (ubiquitin transferase) The name HECT comes from Homologous to the E6-AP Carboxyl Terminus. (more detail) 9 NA Homo sapiens
TAX001384
Genes annotated by the GO term GO:0019783. Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin like sequences from larger leaving groups. (more detail) 9 NA Homo sapiens
MEX001888
Genes associated with Kinase Inhibitor Oxindole Based Inhibitor 54 Genes associated with Kinase Inhibitor Oxindole-Based Inhibitor 54, curated by the Drug Signature Da (more detail) 9 25990557 Homo sapiens
TAX032253
GO:1901748 biological process leukotriene D4 metabolic process The chemical reactions and pathways involving leukotriene D4. (more detail) 9 NA Homo sapiens
IEI012886
Protein protein interactors of human gene SPINK5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SPINK5 (SwissProt ID (more detail) 9 17535438 Homo sapiens
TAX032254
GO:1901750 biological process leukotriene D4 biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene D4. (more detail) 9 NA Homo sapiens
IEI011435
Protein protein interactors of human gene RNF26 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF26 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
TAX023363
GO:0036374 molecular function glutathione hydrolase activity Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. (more detail) 9 NA Homo sapiens
IEI005680
Protein protein interactors of human gene H3 5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene H3-5 (SwissProt ID=Q (more detail) 14 17535438 Homo sapiens
IEI011282
Protein protein interactors of human gene RHOBTB2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RHOBTB2 (SwissProt I (more detail) 14 17535438 Homo sapiens
IEI011375
Protein protein interactors of human gene RNF103 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF103 (SwissProt ID (more detail) 14 17535438 Homo sapiens
IEI007094
Protein protein interactors of human gene KSR2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene KSR2 (SwissProt ID=Q (more detail) 14 17535438 Homo sapiens
WIG000096
IL5 mediated signaling events (more detail) 14 NA Homo sapiens
PEX001173
zf C3HC4 3: Zinc finger, C3HC4 type (RING finger) (more detail) 14 NA Homo sapiens
WAG001077
Apoptotic cleavage of cellular proteins (more detail) 14 NA Homo sapiens
TAX016771
GO:0007077 biological process mitotic nuclear envelope disassembly The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell (more detail) 12 NA Homo sapiens
IEI012174
Protein protein interactors of human gene SHC2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SHC2 (SwissProt ID=P (more detail) 12 17535438 Homo sapiens
TAX028832
GO:0070262 biological process peptidyl serine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine. (more detail) 12 NA Homo sapiens
IEI003378
Protein protein interactors of human gene DCUN1D3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DCUN1D3 (SwissProt I (more detail) 12 17535438 Homo sapiens
IEI011402
Protein protein interactors of human gene RNF150 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF150 (SwissProt ID (more detail) 12 17535438 Homo sapiens
TAX022860
GO:0035404 biological process histone serine phosphorylation The modification of histones by addition of a phosphate group to a serine residue. (more detail) 12 NA Homo sapiens
WIG000355
IL 3 signaling pathway Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding (more detail) 15 NA Homo sapiens
TAX020991
GO:0031434 molecular function mitogen activated protein kinase kinase binding Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any prote (more detail) 15 NA Homo sapiens
MEX001518
Genes associated with Kinase Inhibitor GDC 0941 Genes associated with Kinase Inhibitor GDC-0941, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX001864
Genes associated with Kinase Inhibitor Torin 2 Genes associated with Kinase Inhibitor Torin 2, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
IEI013079
Protein protein interactors of human gene STAP2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene STAP2 (SwissProt ID= (more detail) 15 17535438 Homo sapiens
MOX014386
Genes associated with Computational Drug Signature PD 0183812 Genes associated with Computational Drug Signature PD-0183812, curated by the Drug Signature Databas (more detail) 10 25990557 Homo sapiens
TAX013894
GO:0001867 biological process complement activation, lectin pathway Any process involved in the activation of any of the steps of the lectin pathway of the complement c (more detail) 10 NA Homo sapiens
MOX013102
Genes associated with Computational Drug Signature IK 682 Genes associated with Computational Drug Signature IK-682, curated by the Drug Signature Database (D (more detail) 10 25990557 Homo sapiens
MOX007171
Genes associated with Computational Drug Signature balanol Genes associated with Computational Drug Signature balanol, curated by the Drug Signature Database ( (more detail) 10 25990557 Homo sapiens
PEX001072
FKBP C: FKBP type peptidyl prolyl cis trans isomerase (more detail) 10 NA Homo sapiens
MOX017941
Genes associated with Computational Drug Signature Afatinib Genes associated with Computational Drug Signature Afatinib, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MOX013460
Genes associated with Computational Drug Signature Linifanib Genes associated with Computational Drug Signature Linifanib, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
TAX001291
Genes annotated by the GO term GO:0016706. Catalysis of an oxidation reduction (redox) reaction in which hydrogen or electrons are transferred from 2 oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. (more detail) 10 NA Homo sapiens
WIG000951
Genes involved in IRAK1 recruits IKK complex (more detail) 10 NA Homo sapiens
IEI015829
Protein protein interactors of human gene ZNRF4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ZNRF4 (SwissProt ID= (more detail) 10 17535438 Homo sapiens
TAX022681
GO:0034982 biological process mitochondrial protein processing The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. (more detail) 10 NA Homo sapiens
IEI007758
Protein protein interactors of human gene MBD3L1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MBD3L1 (SwissProt ID (more detail) 10 17535438 Homo sapiens
MOX011633
Genes associated with Computational Drug Signature CHEMBL608532 Genes associated with Computational Drug Signature CHEMBL608532, curated by the Drug Signature Datab (more detail) 8 25990557 Homo sapiens
MEX001325
Genes associated with Kinase Inhibitor Kinome 463 Genes associated with Kinase Inhibitor Kinome_463, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002316
Genes associated with Kinase Inhibitor GW693917A Genes associated with Kinase Inhibitor GW693917A, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001541
Genes associated with Kinase Inhibitor Bay 65 1942 hydrochloride Genes associated with Kinase Inhibitor Bay 65-1942 hydrochloride, curated by the Drug Signature Data (more detail) 8 25990557 Homo sapiens
MEX001547
Genes associated with Kinase Inhibitor 732983 37 8 Genes associated with Kinase Inhibitor 732983-37-8, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MOX009479
Genes associated with Computational Drug Signature CHEMBL292495 Genes associated with Computational Drug Signature CHEMBL292495, curated by the Drug Signature Datab (more detail) 8 25990557 Homo sapiens
TAX017290
GO:0008469 molecular function histone arginine N methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine (more detail) 8 NA Homo sapiens
TAX019802
GO:0019773 cellular component proteasome core complex, alpha subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. (more detail) 8 NA Homo sapiens
PEX002016
JmjN: jmjN domain (more detail) 8 NA Homo sapiens
MEX001920
Genes associated with Kinase Inhibitor GW784307A Genes associated with Kinase Inhibitor GW784307A, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002300
Genes associated with Kinase Inhibitor GSK619487A Genes associated with Kinase Inhibitor GSK619487A, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
PEX002107
Peptidase C1: Papain family cysteine protease (more detail) 8 NA Homo sapiens
TAX021562
GO:0032453 molecular function histone demethylase activity (H3 K4 specific) Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein. (more detail) 8 NA Homo sapiens
TAX019307
GO:0016926 biological process protein desumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target pr (more detail) 8 NA Homo sapiens
WIG000201
Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. na (more detail) 8 NA Homo sapiens
MEX001264
Genes associated with Kinase Inhibitor SB 747651A Genes associated with Kinase Inhibitor SB-747651A, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001657
Genes associated with Kinase Inhibitor Kinome 3177 Genes associated with Kinase Inhibitor Kinome_3177, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001661
Genes associated with Kinase Inhibitor CGP 57380 Genes associated with Kinase Inhibitor CGP 57380, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002242
Genes associated with Kinase Inhibitor Kinome 3566 Genes associated with Kinase Inhibitor Kinome_3566, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001627
Genes associated with Kinase Inhibitor GW770249X Genes associated with Kinase Inhibitor GW770249X, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001462
Genes associated with Kinase Inhibitor SU9516 Genes associated with Kinase Inhibitor SU9516, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001470
Genes associated with Kinase Inhibitor Kinome 258 Genes associated with Kinase Inhibitor Kinome_258, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001489
Genes associated with Kinase Inhibitor Kinome 458 Genes associated with Kinase Inhibitor Kinome_458, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
PEX002015
Ephrin lbd: Ephrin receptor ligand binding domain The Eph receptors, which bind to ephrins Pfam:PF00812 are a large family of receptor tyrosine kinase (more detail) 8 NA Homo sapiens
MEX001586
Genes associated with Kinase Inhibitor Cdk4 Inhibitor Genes associated with Kinase Inhibitor Cdk4 Inhibitor, curated by the Drug Signature Database (DSigD (more detail) 8 25990557 Homo sapiens
MEX002272
Genes associated with Kinase Inhibitor Kinome 876 Genes associated with Kinase Inhibitor Kinome_876, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002351
Genes associated with Kinase Inhibitor 406209 26 5 Genes associated with Kinase Inhibitor 406209-26-5, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001480
Genes associated with Kinase Inhibitor Src Kinase Inhibitor I Genes associated with Kinase Inhibitor Src Kinase Inhibitor I, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
TAX015546
GO:0005005 molecular function transmembrane ephrin receptor activity Combining with a transmembrane ephrin to initiate a change in cell activity. (more detail) 8 NA Homo sapiens
MEX001319
Genes associated with Kinase Inhibitor CHEMBL592030 Genes associated with Kinase Inhibitor CHEMBL592030, curated by the Drug Signature Database (DSigDB) (more detail) 8 25990557 Homo sapiens
MEX001241
Genes associated with Kinase Inhibitor Kinome 77 Genes associated with Kinase Inhibitor Kinome_77, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001338
Genes associated with Kinase Inhibitor 5Z 7 Oxozeaenol Genes associated with Kinase Inhibitor 5Z-7-Oxozeaenol, curated by the Drug Signature Database (DSig (more detail) 8 25990557 Homo sapiens
MEX001609
Genes associated with Kinase Inhibitor 2zv2 Genes associated with Kinase Inhibitor 2zv2, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002309
Genes associated with Kinase Inhibitor Kinome 203 Genes associated with Kinase Inhibitor Kinome_203, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001406
Genes associated with Kinase Inhibitor CHEMBL1967720 Genes associated with Kinase Inhibitor CHEMBL1967720, curated by the Drug Signature Database (DSigDB (more detail) 8 25990557 Homo sapiens
MOX014852
Genes associated with Computational Drug Signature ro 32 0432 Genes associated with Computational Drug Signature ro 32-0432, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
MOX001093
Genes associated with Computational Drug Signature SODIUM HYDROSULFIDE Genes associated with Computational Drug Signature SODIUM HYDROSULFIDE, curated by the Drug Signatur (more detail) 8 25990557 Homo sapiens
MEX002140
Genes associated with Kinase Inhibitor Vatalanib Genes associated with Kinase Inhibitor Vatalanib, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002257
Genes associated with Kinase Inhibitor 4 anilinopyrimidine 8c Genes associated with Kinase Inhibitor 4-anilinopyrimidine 8c, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
TAX017198
GO:0008318 molecular function protein prenyltransferase activity Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group (more detail) 8 NA Homo sapiens
MOX015025
Genes associated with Computational Drug Signature SC 44463 Genes associated with Computational Drug Signature SC-44463, curated by the Drug Signature Database (more detail) 8 25990557 Homo sapiens
TAX029096
GO:0070739 molecular function protein glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue (more detail) 8 NA Homo sapiens
TAX023318
GO:0036289 biological process peptidyl serine autophosphorylation The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine r (more detail) 8 NA Homo sapiens
TAX022635
GO:0034720 biological process histone H3 K4 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the his (more detail) 8 NA Homo sapiens
TAX022977
GO:0035608 biological process protein deglutamylation The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encode (more detail) 8 NA Homo sapiens
TAX029097
GO:0070740 molecular function tubulin glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl (more detail) 8 NA Homo sapiens
TAX030195
GO:0085020 biological process protein K6 linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine (more detail) 8 NA Homo sapiens
MOX003268
Genes associated with Computational Drug Signature Dehydroxymethylepoxyquinomicin Genes associated with Computational Drug Signature Dehydroxymethylepoxyquinomicin, curated by the Dr (more detail) 13 25990557 Homo sapiens
MOX003404
Genes associated with Computational Drug Signature Talmapimod Genes associated with Computational Drug Signature Talmapimod, curated by the Drug Signature Databas (more detail) 13 25990557 Homo sapiens
TAX026083
GO:0048188 cellular component Set1C/COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex c (more detail) 13 NA Homo sapiens
WIG000278
CBL mediated ligand induced downregulation of EGF receptors As with many cell-surface receptors, activation of the EGF receptor can result in receptor internali (more detail) 13 NA Homo sapiens
IEI003982
Protein protein interactors of human gene EFNA5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EFNA5 (SwissProt ID= (more detail) 13 17535438 Homo sapiens
IEI014580
Protein protein interactors of human gene UBE2J2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2J2 (SwissProt ID (more detail) 13 17535438 Homo sapiens
IEI003377
Protein protein interactors of human gene DCUN1D2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DCUN1D2 (SwissProt I (more detail) 13 17535438 Homo sapiens
IEI007759
Protein protein interactors of human gene MBD3L2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MBD3L2 (SwissProt ID (more detail) 11 17535438 Homo sapiens
IEI010773
Protein protein interactors of human gene PTX3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PTX3 (SwissProt ID=P (more detail) 11 17535438 Homo sapiens
TAX024446
GO:0043560 molecular function insulin receptor substrate binding Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins (more detail) 11 NA Homo sapiens
WIG000411
Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle Sonic Hedgehog (Shh) is a secreted protein identified genetically as an important developmental fact (more detail) 11 NA Homo sapiens
TAX016573
GO:0006751 biological process glutathione catabolic process The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutam (more detail) 11 NA Homo sapiens
MOX015148
Genes associated with Computational Drug Signature Sorafenib Genes associated with Computational Drug Signature Sorafenib, curated by the Drug Signature Database (more detail) 11 25990557 Homo sapiens
WIG000396
Deregulation of CDK5 in Alzheimers Disease Cyclin-dependent kinase 5 (cdk5), a multi-functional kinase, and its neuron-specific activator p35 a (more detail) 11 NA Homo sapiens
TAX022022
GO:0033182 biological process regulation of histone ubiquitination Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a h (more detail) 9 NA Homo sapiens
MOX015748
Genes associated with Computational Drug Signature UNII J8AY0Z4CBP Genes associated with Computational Drug Signature UNII-J8AY0Z4CBP, curated by the Drug Signature Da (more detail) 9 25990557 Homo sapiens
TAX031751
GO:0150065 biological process regulation of deacetylase activity Any process that modulates the frequency, rate or extent of deacetylase activity. (more detail) 9 NA Homo sapiens
MOX001834
Genes associated with Computational Drug Signature NSC336628 Genes associated with Computational Drug Signature NSC336628, curated by the Drug Signature Database (more detail) 9 25990557 Homo sapiens
MOX010669
Genes associated with Computational Drug Signature CHEMBL448246 Genes associated with Computational Drug Signature CHEMBL448246, curated by the Drug Signature Datab (more detail) 9 25990557 Homo sapiens
MOX014196
Genes associated with Computational Drug Signature nu6102 Genes associated with Computational Drug Signature nu6102, curated by the Drug Signature Database (D (more detail) 9 25990557 Homo sapiens
MOX008615
Genes associated with Computational Drug Signature CHEMBL204357 Genes associated with Computational Drug Signature CHEMBL204357, curated by the Drug Signature Datab (more detail) 9 25990557 Homo sapiens
WIG000856
Genes involved in G2/M DNA damage checkpoint (more detail) 9 NA Homo sapiens
TAX029193
GO:0070933 biological process histone H4 deacetylation The modification of histone H4 by the removal of one or more acetyl groups. (more detail) 9 NA Homo sapiens
TAX022916
GO:0035520 biological process monoubiquitinated protein deubiquitination The removal of the ubiquitin group from a monoubiquitinated protein. (more detail) 9 NA Homo sapiens
IEI001403
Protein protein interactors of human gene BORA from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene BORA (SwissProt ID=Q (more detail) 9 17535438 Homo sapiens
MOX006363
Genes associated with Computational Drug Signature 722544 51 6 Genes associated with Computational Drug Signature 722544-51-6, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX011447
Genes associated with Computational Drug Signature CHEMBL575896 Genes associated with Computational Drug Signature CHEMBL575896, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
MOX011982
Genes associated with Computational Drug Signature Cipemastat Genes associated with Computational Drug Signature Cipemastat, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
TAX019818
GO:0019798 molecular function procollagen proline dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L (more detail) 7 NA Homo sapiens
TAX015322
GO:0004691 molecular function cAMP dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the pres (more detail) 7 NA Homo sapiens
MOX011736
Genes associated with Computational Drug Signature CHEMBL73495 Genes associated with Computational Drug Signature CHEMBL73495, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX011743
Genes associated with Computational Drug Signature CHEMBL74983 Genes associated with Computational Drug Signature CHEMBL74983, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
FEX002728
Sarcoma Baird05 12genes Table 2. Tyrosine kinases and receptor tyrosine kinases associated with individual tumor groups (sho (more detail) 7 16230383 Homo sapiens
MEX001322
Genes associated with Kinase Inhibitor CHEMBL189231 Genes associated with Kinase Inhibitor CHEMBL189231, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MEX001540
Genes associated with Kinase Inhibitor GW300660X Genes associated with Kinase Inhibitor GW300660X, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001808
Genes associated with Kinase Inhibitor TG003 Genes associated with Kinase Inhibitor TG003, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001824
Genes associated with Kinase Inhibitor Kinome 575 Genes associated with Kinase Inhibitor Kinome_575, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX006665
Genes associated with Computational Drug Signature AGN PC 001QKA Genes associated with Computational Drug Signature AGN-PC-001QKA, curated by the Drug Signature Data (more detail) 7 25990557 Homo sapiens
MOX011430
Genes associated with Computational Drug Signature CHEMBL574589 Genes associated with Computational Drug Signature CHEMBL574589, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
TAX019812
GO:0019784 molecular function NEDD8 specific protease activity Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated (more detail) 7 NA Homo sapiens
TAX015311
GO:0004673 molecular function protein histidine kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. (more detail) 7 NA Homo sapiens
TAX015316
GO:0004679 molecular function AMP activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the pres (more detail) 7 NA Homo sapiens
PEX001284
Hist deacetyl: Histone deacetylase domain Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is cau (more detail) 7 NA Homo sapiens
WAG000881
Cyclin A/B1 associated events during G2/M transition (more detail) 7 NA Homo sapiens
MEX001379
Genes associated with Kinase Inhibitor Kinome 683 Genes associated with Kinase Inhibitor Kinome_683, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001916
Genes associated with Kinase Inhibitor (E) N Methyl 2 ((3 (2 (pyridin 2 yl)vinyl) 1H indazol 6 yl)thio)benzamide Genes associated with Kinase Inhibitor (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)th (more detail) 7 25990557 Homo sapiens
MEX001607
Genes associated with Kinase Inhibitor Kinome 41 Genes associated with Kinase Inhibitor Kinome_41, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002330
Genes associated with Kinase Inhibitor Kinome 423 Genes associated with Kinase Inhibitor Kinome_423, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001494
Genes associated with Kinase Inhibitor EGFR/ErbB 2/ErbB 4 Inhibitor Genes associated with Kinase Inhibitor EGFR/ErbB-2/ErbB-4 Inhibitor, curated by the Drug Signature D (more detail) 7 25990557 Homo sapiens
MEX002185
Genes associated with Kinase Inhibitor Kinome 507 Genes associated with Kinase Inhibitor Kinome_507, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX013193
Genes associated with Computational Drug Signature isogranulatimide Genes associated with Computational Drug Signature isogranulatimide, curated by the Drug Signature D (more detail) 7 25990557 Homo sapiens
TAX019505
GO:0018243 biological process protein O linked glycosylation via threonine The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; (more detail) 7 NA Homo sapiens
TAX015545
GO:0005004 molecular function GPI linked ephrin receptor activity Combining with a GPI-anchored ephrin to initiate a change in cell activity. (more detail) 7 NA Homo sapiens
TAX015329
GO:0004703 molecular function G protein coupled receptor kinase activity Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosp (more detail) 7 NA Homo sapiens
PEX000267
BIR: Inhibitor of Apoptosis domain BIR stands for Baculovirus Inhibitor of apoptosis protein Repeat. It is found repeated in inhibitor (more detail) 7 NA Homo sapiens
PEX000031
Peptidase M14: Zinc carboxypeptidase (more detail) 7 NA Homo sapiens
PEX000832
Proteasome A N: Proteasome subunit A N terminal signature This domain is conserved in the A subunits of the proteasome complex proteins. (more detail) 7 NA Homo sapiens
MOX014397
Genes associated with Computational Drug Signature PD173955 Genes associated with Computational Drug Signature PD173955, curated by the Drug Signature Database (more detail) 7 25990557 Homo sapiens
MEX001845
Genes associated with Kinase Inhibitor Lapatinib Genes associated with Kinase Inhibitor Lapatinib, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX005843
Genes associated with Computational Drug Signature 3 (4 Hydroxy phenyl) 2,3 diphenyl acrylonitrile Genes associated with Computational Drug Signature 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile, (more detail) 7 25990557 Homo sapiens
MOX013239
Genes associated with Computational Drug Signature JNJ 10198409 Genes associated with Computational Drug Signature JNJ-10198409, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
TAX019884
GO:0019919 biological process peptidyl arginine methylation, to asymmetrical dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-argini (more detail) 7 NA Homo sapiens
TAX015345
GO:0004723 molecular function calcium dependent protein serine/threonine phosphatase activity Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein (more detail) 7 NA Homo sapiens
TAX015347
GO:0004726 molecular function non membrane spanning protein tyrosine phosphatase activity Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spa (more detail) 7 NA Homo sapiens
PEX001617
Cullin: Cullin family (more detail) 7 NA Homo sapiens
MOX015778
Genes associated with Computational Drug Signature UNII ZZ6VH5MZ17 Genes associated with Computational Drug Signature UNII-ZZ6VH5MZ17, curated by the Drug Signature Da (more detail) 7 25990557 Homo sapiens
MEX001877
Genes associated with Kinase Inhibitor CHEMBL508928 Genes associated with Kinase Inhibitor CHEMBL508928, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MEX002291
Genes associated with Kinase Inhibitor CHEMBL188268 Genes associated with Kinase Inhibitor CHEMBL188268, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MEX002157
Genes associated with Kinase Inhibitor Kinome 2847 Genes associated with Kinase Inhibitor Kinome_2847, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX006666
Genes associated with Computational Drug Signature AGN PC 001QKE Genes associated with Computational Drug Signature AGN-PC-001QKE, curated by the Drug Signature Data (more detail) 7 25990557 Homo sapiens
MOX011199
Genes associated with Computational Drug Signature CHEMBL538718 Genes associated with Computational Drug Signature CHEMBL538718, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
TAX015557
GO:0005021 molecular function vascular endothelial growth factor activated receptor activity Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the pl (more detail) 7 NA Homo sapiens
MEX001256
Genes associated with Kinase Inhibitor 1 [4 (4 amino 6 methylthieno[2,3 d]pyrimidin 5 yl)phenyl] 3 (3,5 dimethylphenyl)urea Genes associated with Kinase Inhibitor 1-[4-(4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]-3-( (more detail) 7 25990557 Homo sapiens
MEX001611
Genes associated with Kinase Inhibitor Kinome 125 Genes associated with Kinase Inhibitor Kinome_125, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001619
Genes associated with Kinase Inhibitor GW410563A Genes associated with Kinase Inhibitor GW410563A, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001936
Genes associated with Kinase Inhibitor SU 5416 Genes associated with Kinase Inhibitor SU 5416, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002282
Genes associated with Kinase Inhibitor Akt inhibitor VIII Genes associated with Kinase Inhibitor Akt inhibitor VIII, curated by the Drug Signature Database (D (more detail) 7 25990557 Homo sapiens
MEX001693
Genes associated with Kinase Inhibitor Kinome 421 Genes associated with Kinase Inhibitor Kinome_421, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002065
Genes associated with Kinase Inhibitor Kinome 1078 Genes associated with Kinase Inhibitor Kinome_1078, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX006051
Genes associated with Computational Drug Signature 4 cycloheptyliden(4 hydroxyphenyl)methylphenol Genes associated with Computational Drug Signature 4-cycloheptyliden(4-hydroxyphenyl)methylphenol, c (more detail) 7 25990557 Homo sapiens
PEX000009
OTU: OTU like cysteine protease This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumou (more detail) 7 NA Homo sapiens
MOX012111
Genes associated with Computational Drug Signature Cyclofenil diphenol Genes associated with Computational Drug Signature Cyclofenil diphenol, curated by the Drug Signatur (more detail) 7 25990557 Homo sapiens
MOX014469
Genes associated with Computational Drug Signature Phenol, 4,4' (3 methyl 1 butenylidene)bis Genes associated with Computational Drug Signature Phenol, 4,4'-(3-methyl-1-butenylidene)bis-, curat (more detail) 7 25990557 Homo sapiens
MOX014577
Genes associated with Computational Drug Signature PONATINIB Genes associated with Computational Drug Signature PONATINIB, curated by the Drug Signature Database (more detail) 7 25990557 Homo sapiens
MEX001660
Genes associated with Kinase Inhibitor GW827099X Genes associated with Kinase Inhibitor GW827099X, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001608
Genes associated with Kinase Inhibitor Kinome 332 Genes associated with Kinase Inhibitor Kinome_332, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002270
Genes associated with Kinase Inhibitor Tozasertib Genes associated with Kinase Inhibitor Tozasertib, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001637
Genes associated with Kinase Inhibitor MRT67307 Genes associated with Kinase Inhibitor MRT67307, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX006664
Genes associated with Computational Drug Signature AGN PC 001QK8 Genes associated with Computational Drug Signature AGN-PC-001QK8, curated by the Drug Signature Data (more detail) 7 25990557 Homo sapiens
MOX011418
Genes associated with Computational Drug Signature CHEMBL573935 Genes associated with Computational Drug Signature CHEMBL573935, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
TAX017916
GO:0010452 biological process histone H3 K36 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of (more detail) 7 NA Homo sapiens
MOX011750
Genes associated with Computational Drug Signature CHEMBL76100 Genes associated with Computational Drug Signature CHEMBL76100, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MEX001754
Genes associated with Kinase Inhibitor Kinome 471 Genes associated with Kinase Inhibitor Kinome_471, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX009490
Genes associated with Computational Drug Signature CHEMBL294120 Genes associated with Computational Drug Signature CHEMBL294120, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
TAX019329
GO:0017002 molecular function activin activated receptor activity Combining with activin and transmitting the signal from one side of the membrane to the other to ini (more detail) 7 NA Homo sapiens
PEX002651
Asp: Eukaryotic aspartyl protease Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably a (more detail) 7 NA Homo sapiens
MOX014637
Genes associated with Computational Drug Signature Prostratin Genes associated with Computational Drug Signature Prostratin, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
MEX001245
Genes associated with Kinase Inhibitor Kinome 131 Genes associated with Kinase Inhibitor Kinome_131, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002258
Genes associated with Kinase Inhibitor GW795486X Genes associated with Kinase Inhibitor GW795486X, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001614
Genes associated with Kinase Inhibitor Kinome 245 Genes associated with Kinase Inhibitor Kinome_245, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002271
Genes associated with Kinase Inhibitor Oxindole Based Inhibitor 80 Genes associated with Kinase Inhibitor Oxindole-Based Inhibitor 80, curated by the Drug Signature Da (more detail) 7 25990557 Homo sapiens
MEX001792
Genes associated with Kinase Inhibitor GSK994854A Genes associated with Kinase Inhibitor GSK994854A, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001870
Genes associated with Kinase Inhibitor CHEMBL458415 Genes associated with Kinase Inhibitor CHEMBL458415, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
TAX022861
GO:0035405 biological process histone threonine phosphorylation The modification of histones by addition of a phosphate group to a threonine residue. (more detail) 7 NA Homo sapiens
TAX022755
GO:0035184 molecular function histone threonine kinase activity Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any (more detail) 7 NA Homo sapiens
TAX022682
GO:0034983 biological process peptidyl lysine deacetylation The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. (more detail) 7 NA Homo sapiens
TAX022773
GO:0035242 molecular function protein arginine omega N asymmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is o (more detail) 7 NA Homo sapiens
FEX000816
Cervical VazquezOrtiz05 24genes Table 1. Summary of altered gene expression in cervical cancer by cDNA array. Ratio (T/N) intensity (more detail) 12 15989693 Homo sapiens
WIG000805
Genes involved in Downregulation of ERBB2:ERBB3 signaling (more detail) 12 NA Homo sapiens
PEX002387
FGF: Fibroblast growth factor Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide (more detail) 12 NA Homo sapiens
WIG000685
Genes involved in AKT phosphorylates targets in the cytosol (more detail) 12 NA Homo sapiens
TAX026019
GO:0048012 biological process hepatocyte growth factor receptor signaling pathway The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor (more detail) 12 NA Homo sapiens
MOX013103
Genes associated with Computational Drug Signature Ilomastat Genes associated with Computational Drug Signature Ilomastat, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
TAX015866
GO:0005675 cellular component holo TFIIH complex A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the lar (more detail) 12 NA Homo sapiens
TAX027414
GO:0052629 molecular function phosphatidylinositol 3,5 bisphosphate 3 phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl- (more detail) 12 NA Homo sapiens
IEI012033
Protein protein interactors of human gene SERPINB13 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SERPINB13 (SwissProt (more detail) 10 17535438 Homo sapiens
TAX034131
GO:1990001 biological process inhibition of cysteine type endopeptidase activity involved in apoptotic process Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an a (more detail) 10 NA Homo sapiens
TAX032698
GO:1902916 biological process positive regulation of protein polyubiquitination Any process that activates or increases the frequency, rate or extent of protein polyubiquitination. (more detail) 10 NA Homo sapiens
IEI013729
Protein protein interactors of human gene TIMP3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TIMP3 (SwissProt ID= (more detail) 10 17535438 Homo sapiens
IEI014826
Protein protein interactors of human gene UVSSA from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UVSSA (SwissProt ID= (more detail) 10 17535438 Homo sapiens
IEI007734
Protein protein interactors of human gene MASP2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MASP2 (SwissProt ID= (more detail) 10 17535438 Homo sapiens
IEI008542
Protein protein interactors of human gene NACC2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NACC2 (SwissProt ID= (more detail) 10 17535438 Homo sapiens
TAX030815
GO:0097354 biological process prenylation The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups (more detail) 10 NA Homo sapiens
MOX005477
Genes associated with Computational Drug Signature 10Z Hymenialdisine Genes associated with Computational Drug Signature 10Z-Hymenialdisine, curated by the Drug Signature (more detail) 10 25990557 Homo sapiens
TAX027064
GO:0051567 biological process histone H3 K9 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of t (more detail) 10 NA Homo sapiens
MAX002889
Protein kinase genes most significantly up regulated in ASPS (alveolar soft part sarcoma) tumors compared to four other types of primitive sarcomas. Specific chromosomal translocations encoding chimeric transcription factors are considered to play c (more detail) 10 NA Homo sapiens
TAX001339
Genes annotated by the GO term GO:0004712. Catalysis of the reaction: ATP + a protein serine/threonine/tyrosine = ADP + protein serine/threonine/tyrosine phosphate. (more detail) 10 NA Homo sapiens
MOX003319
Genes associated with Computational Drug Signature UNII W39547M0FP Genes associated with Computational Drug Signature UNII-W39547M0FP, curated by the Drug Signature Da (more detail) 10 25990557 Homo sapiens
TAX019522
GO:0018342 biological process protein prenylation The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups (more detail) 10 NA Homo sapiens
TAX017946
GO:0010510 biological process regulation of acetyl CoA biosynthetic process from pyruvate Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resu (more detail) 8 NA Homo sapiens
MOX014671
Genes associated with Computational Drug Signature Purvalanol B Genes associated with Computational Drug Signature Purvalanol B, curated by the Drug Signature Datab (more detail) 8 25990557 Homo sapiens
TAX026733
GO:0051013 biological process microtubule severing The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dim (more detail) 8 NA Homo sapiens
MOX016138
Genes associated with Computational Drug Signature 6 aminohexanoic acid Genes associated with Computational Drug Signature 6-aminohexanoic acid, curated by the Drug Signatu (more detail) 8 25990557 Homo sapiens
MOX015639
Genes associated with Computational Drug Signature Triphenylacrylonitrile Genes associated with Computational Drug Signature Triphenylacrylonitrile, curated by the Drug Signa (more detail) 8 25990557 Homo sapiens
MAX002393
G1 to S phase regulators significantly changed in DanG cells (pancreatic cancer) treated with Ly294002 [PubChem=3973] , a phosphoinositide 3 kinase (PI3K) inhibitor. The phosphoinositide-3-kinase (PI3K)/AKT signaling pathway controls fundamental processes of cancer (more detail) 8 NA Homo sapiens
WIG000771
Genes involved in Creation of C4 and C2 activators (more detail) 8 NA Homo sapiens
MOX017541
Genes associated with Computational Drug Signature PONATINIB Genes associated with Computational Drug Signature PONATINIB, curated by the Drug Signature Database (more detail) 8 25990557 Homo sapiens
TAX016709
GO:0006975 biological process DNA damage induced protein phosphorylation The widespread phosphorylation of various molecules, triggering many downstream processes, that occu (more detail) 8 NA Homo sapiens
IEI006924
Protein protein interactors of human gene KLHL21 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene KLHL21 (SwissProt ID (more detail) 8 17535438 Homo sapiens
IEI007712
Protein protein interactors of human gene MARCHF3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MARCHF3 (SwissProt I (more detail) 8 17535438 Homo sapiens
IEI005586
Protein protein interactors of human gene GTF2H5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GTF2H5 (SwissProt ID (more detail) 8 17535438 Homo sapiens
IEI012242
Protein protein interactors of human gene SIT1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SIT1 (SwissProt ID=Q (more detail) 8 17535438 Homo sapiens
IEI004283
Protein protein interactors of human gene ERO1B from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ERO1B (SwissProt ID= (more detail) 8 17535438 Homo sapiens
IEI002453
Protein protein interactors of human gene CHAT from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CHAT (SwissProt ID=P (more detail) 8 17535438 Homo sapiens
IEI001586
Protein protein interactors of human gene C2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene C2 (SwissProt ID=P06 (more detail) 8 17535438 Homo sapiens
MEX002056
Genes associated with Kinase Inhibitor Kinome 477 Genes associated with Kinase Inhibitor Kinome_477, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001802
Genes associated with Kinase Inhibitor Kinome 3522 Genes associated with Kinase Inhibitor Kinome_3522, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001521
Genes associated with Kinase Inhibitor Kinome 1109 Genes associated with Kinase Inhibitor Kinome_1109, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001220
Genes associated with Kinase Inhibitor Go 6976 Genes associated with Kinase Inhibitor Go 6976, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
TAX019102
GO:0016576 biological process histone dephosphorylation The modification of histones by removal of phosphate groups. (more detail) 6 NA Homo sapiens
TAX025844
GO:0046975 molecular function histone methyltransferase activity (H3 K36 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl- (more detail) 6 NA Homo sapiens
PEX000751
Reprolysin: Reprolysin (M12B) family zinc metalloprotease The members of this family are enzymes that cleave peptides. These proteases require zinc for cataly (more detail) 6 NA Homo sapiens
PEX001552
zf UBP: Zn finger in ubiquitin hydrolases and other protein (more detail) 6 NA Homo sapiens
PEX000885
Cyclin C: Cyclin, C terminal domain Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is r (more detail) 6 NA Homo sapiens
MEX001230
Genes associated with Kinase Inhibitor amlexanox Genes associated with Kinase Inhibitor amlexanox, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001306
Genes associated with Kinase Inhibitor Kinome 1286 Genes associated with Kinase Inhibitor Kinome_1286, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002217
Genes associated with Kinase Inhibitor Kinome 838 Genes associated with Kinase Inhibitor Kinome_838, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002059
Genes associated with Kinase Inhibitor isogranulatimide Genes associated with Kinase Inhibitor isogranulatimide, curated by the Drug Signature Database (DSi (more detail) 6 25990557 Homo sapiens
MEX002067
Genes associated with Kinase Inhibitor INDIRUBIN 3' MONOXIME Genes associated with Kinase Inhibitor INDIRUBIN-3'-MONOXIME, curated by the Drug Signature Database (more detail) 6 25990557 Homo sapiens
MEX002088
Genes associated with Kinase Inhibitor CHEMBL403402 Genes associated with Kinase Inhibitor CHEMBL403402, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX001458
Genes associated with Kinase Inhibitor Kinome 1067 Genes associated with Kinase Inhibitor Kinome_1067, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001459
Genes associated with Kinase Inhibitor GW784752X Genes associated with Kinase Inhibitor GW784752X, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001827
Genes associated with Kinase Inhibitor WHI P154 Genes associated with Kinase Inhibitor WHI-P154, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001863
Genes associated with Kinase Inhibitor XMD8 92 Genes associated with Kinase Inhibitor XMD8-92, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002190
Genes associated with Kinase Inhibitor Kinome 464 Genes associated with Kinase Inhibitor Kinome_464, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MOX013717
Genes associated with Computational Drug Signature Midostaurin Genes associated with Computational Drug Signature Midostaurin, curated by the Drug Signature Databa (more detail) 6 25990557 Homo sapiens
MOX014436
Genes associated with Computational Drug Signature PF 573228 Genes associated with Computational Drug Signature PF 573228, curated by the Drug Signature Database (more detail) 6 25990557 Homo sapiens
WAG001313
Cyclin A:Cdk2 associated events at S phase entry (more detail) 6 NA Homo sapiens
MAX003295
Selected genes down regulated in DU145 and PC 3 cells (prostate cancer) after treatment with the NSAID (non steroid anti inflammatory drug) sulindac [PubChem=5352] . Numerous studies show that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in chemopreve (more detail) 6 NA Homo sapiens
MEX001437
Genes associated with Kinase Inhibitor GW396574X Genes associated with Kinase Inhibitor GW396574X, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002244
Genes associated with Kinase Inhibitor GW830365A Genes associated with Kinase Inhibitor GW830365A, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001583
Genes associated with Kinase Inhibitor Kinome 424 Genes associated with Kinase Inhibitor Kinome_424, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001994
Genes associated with Kinase Inhibitor Kinome 1896 Genes associated with Kinase Inhibitor Kinome_1896, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001757
Genes associated with Kinase Inhibitor Kinome 132 Genes associated with Kinase Inhibitor Kinome_132, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001784
Genes associated with Kinase Inhibitor TPCA 1 Genes associated with Kinase Inhibitor TPCA-1, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001814
Genes associated with Kinase Inhibitor CHEMBL273187 Genes associated with Kinase Inhibitor CHEMBL273187, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX001865
Genes associated with Kinase Inhibitor CHEMBL1090360 Genes associated with Kinase Inhibitor CHEMBL1090360, curated by the Drug Signature Database (DSigDB (more detail) 6 25990557 Homo sapiens
MEX001216
Genes associated with Kinase Inhibitor Oxindole Based Inhibitor 19 Genes associated with Kinase Inhibitor Oxindole-Based Inhibitor 19, curated by the Drug Signature Da (more detail) 6 25990557 Homo sapiens
MOX007562
Genes associated with Computational Drug Signature CEP 5104 Genes associated with Computational Drug Signature CEP-5104, curated by the Drug Signature Database (more detail) 6 25990557 Homo sapiens
TAX015330
GO:0004704 molecular function NF kappaB inducing kinase activity Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase comp (more detail) 6 NA Homo sapiens
PEX002503
Kelch 1: Kelch motif The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copi (more detail) 6 NA Homo sapiens
PEX000244
PG binding 1: Putative peptidoglycan binding domain This domain is composed of three alpha helices 1. This domain is found at the N or C terminus of a (more detail) 6 NA Homo sapiens
MEX001281
Genes associated with Kinase Inhibitor Kinome 768 Genes associated with Kinase Inhibitor Kinome_768, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001302
Genes associated with Kinase Inhibitor Kinome 569 Genes associated with Kinase Inhibitor Kinome_569, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001359
Genes associated with Kinase Inhibitor CHEMBL374044 Genes associated with Kinase Inhibitor CHEMBL374044, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX001908
Genes associated with Kinase Inhibitor CHEMBL213505 Genes associated with Kinase Inhibitor CHEMBL213505, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX002302
Genes associated with Kinase Inhibitor Kinome 108 Genes associated with Kinase Inhibitor Kinome_108, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002022
Genes associated with Kinase Inhibitor 877400 66 3 Genes associated with Kinase Inhibitor 877400-66-3, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001487
Genes associated with Kinase Inhibitor GW683134A Genes associated with Kinase Inhibitor GW683134A, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001173
Genes associated with Approved Drug ponatinib Genes associated with Approved Drug ponatinib, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MOX009556
Genes associated with Computational Drug Signature CHEMBL306412 Genes associated with Computational Drug Signature CHEMBL306412, curated by the Drug Signature Datab (more detail) 6 25990557 Homo sapiens
TAX017256
GO:0008420 molecular function RNA polymerase II CTD heptapeptide repeat phosphatase activity Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polyme (more detail) 6 NA Homo sapiens
TAX019504
GO:0018242 biological process protein O linked glycosylation via serine The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the m (more detail) 6 NA Homo sapiens
TAX019815
GO:0019788 molecular function NEDD8 transferase activity Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NE (more detail) 6 NA Homo sapiens
PEX001578
Furin like: Furin like cysteine rich region (more detail) 6 NA Homo sapiens
WAG000269
EphrinB EPHB pathway (more detail) 6 NA Homo sapiens
MEX001242
Genes associated with Kinase Inhibitor Entrectinib Genes associated with Kinase Inhibitor Entrectinib, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001257
Genes associated with Kinase Inhibitor CHEMBL402846 Genes associated with Kinase Inhibitor CHEMBL402846, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX002210
Genes associated with Kinase Inhibitor LY 294002 Genes associated with Kinase Inhibitor LY 294002, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002150
Genes associated with Kinase Inhibitor pp1 analog Genes associated with Kinase Inhibitor pp1 analog, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
TAX017900
GO:0010340 molecular function carboxyl O methyltransferase activity Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a (more detail) 6 NA Homo sapiens
PEX002476
Hemopexin: Hemopexin Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur (more detail) 6 NA Homo sapiens
PEX001609
Recep L domain: Receptor L domain The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists o (more detail) 6 NA Homo sapiens
MEX001400
Genes associated with Kinase Inhibitor Kinome 461 Genes associated with Kinase Inhibitor Kinome_461, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002241
Genes associated with Kinase Inhibitor BI 78D3 Genes associated with Kinase Inhibitor BI-78D3, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001986
Genes associated with Kinase Inhibitor PHA 767491 Genes associated with Kinase Inhibitor PHA-767491, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002349
Genes associated with Kinase Inhibitor CHEMBL373798 Genes associated with Kinase Inhibitor CHEMBL373798, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX002362
Genes associated with Kinase Inhibitor BI 2536 Genes associated with Kinase Inhibitor BI 2536, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002021
Genes associated with Kinase Inhibitor Flt 3 Inhibitor II Genes associated with Kinase Inhibitor Flt-3 Inhibitor II, curated by the Drug Signature Database (D (more detail) 6 25990557 Homo sapiens
MEX002085
Genes associated with Kinase Inhibitor RNA Dependent Protein Kinase Inhibitor, Negative Control Genes associated with Kinase Inhibitor RNA-Dependent Protein Kinase Inhibitor, Negative Control, cur (more detail) 6 25990557 Homo sapiens
MEX001511
Genes associated with Kinase Inhibitor Kinome 584 Genes associated with Kinase Inhibitor Kinome_584, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002162
Genes associated with Kinase Inhibitor CHEMBL260092 Genes associated with Kinase Inhibitor CHEMBL260092, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX002194
Genes associated with Kinase Inhibitor Kinome 460 Genes associated with Kinase Inhibitor Kinome_460, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
TAX027311
GO:0051998 molecular function protein carboxyl O methyltransferase activity Catalysis of the transfer of a methyl group to a carboxyl group on a protein. (more detail) 6 NA Homo sapiens
TAX015936
GO:0005787 cellular component signal peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal seque (more detail) 6 NA Homo sapiens
MEX001299
Genes associated with Kinase Inhibitor Kinome 2199 Genes associated with Kinase Inhibitor Kinome_2199, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001648
Genes associated with Kinase Inhibitor Kinome 2200 Genes associated with Kinase Inhibitor Kinome_2200, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001626
Genes associated with Kinase Inhibitor CHEMBL1096634 Genes associated with Kinase Inhibitor CHEMBL1096634, curated by the Drug Signature Database (DSigDB (more detail) 6 25990557 Homo sapiens
MEX001990
Genes associated with Kinase Inhibitor GSK269962A Genes associated with Kinase Inhibitor GSK269962A, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001672
Genes associated with Kinase Inhibitor Kinome 2672 Genes associated with Kinase Inhibitor Kinome_2672, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001526
Genes associated with Kinase Inhibitor Kinome 2680 Genes associated with Kinase Inhibitor Kinome_2680, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MOX007182
Genes associated with Computational Drug Signature batimastat Genes associated with Computational Drug Signature batimastat, curated by the Drug Signature Databas (more detail) 6 25990557 Homo sapiens
MOX012705
Genes associated with Computational Drug Signature Flt 3 Inhibitor II Genes associated with Computational Drug Signature Flt-3 Inhibitor II, curated by the Drug Signature (more detail) 6 25990557 Homo sapiens
MOX014398
Genes associated with Computational Drug Signature PD180970 Genes associated with Computational Drug Signature PD180970, curated by the Drug Signature Database (more detail) 6 25990557 Homo sapiens
TAX013282
GO:0000155 molecular function phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular (more detail) 6 NA Homo sapiens
MEX001231
Genes associated with Kinase Inhibitor CHEMBL1096626 Genes associated with Kinase Inhibitor CHEMBL1096626, curated by the Drug Signature Database (DSigDB (more detail) 6 25990557 Homo sapiens
MEX002315
Genes associated with Kinase Inhibitor CHEMBL404366 Genes associated with Kinase Inhibitor CHEMBL404366, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX002219
Genes associated with Kinase Inhibitor HYPOTHEMYCIN Genes associated with Kinase Inhibitor HYPOTHEMYCIN, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX001593
Genes associated with Kinase Inhibitor Kinome 1056 Genes associated with Kinase Inhibitor Kinome_1056, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001954
Genes associated with Kinase Inhibitor CHEMBL271441 Genes associated with Kinase Inhibitor CHEMBL271441, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX001997
Genes associated with Kinase Inhibitor Chelerythrine chloride Genes associated with Kinase Inhibitor Chelerythrine chloride, curated by the Drug Signature Databas (more detail) 6 25990557 Homo sapiens
MEX002364
Genes associated with Kinase Inhibitor Kinome 476 Genes associated with Kinase Inhibitor Kinome_476, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001744
Genes associated with Kinase Inhibitor CHEMBL1964441 Genes associated with Kinase Inhibitor CHEMBL1964441, curated by the Drug Signature Database (DSigDB (more detail) 6 25990557 Homo sapiens
MEX001780
Genes associated with Kinase Inhibitor Kinome 875 Genes associated with Kinase Inhibitor Kinome_875, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX001807
Genes associated with Kinase Inhibitor Kinome 583 Genes associated with Kinase Inhibitor Kinome_583, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MOX003412
Genes associated with Computational Drug Signature COX 2 Inhibitor I Genes associated with Computational Drug Signature COX-2 Inhibitor I, curated by the Drug Signature (more detail) 6 25990557 Homo sapiens
MOX013789
Genes associated with Computational Drug Signature Motesanib Genes associated with Computational Drug Signature Motesanib, curated by the Drug Signature Database (more detail) 6 25990557 Homo sapiens
TAX016483
GO:0006627 biological process protein processing involved in protein targeting to mitochondrion The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process (more detail) 6 NA Homo sapiens
PEX002036
Peptidase M1: Peptidase family M1 domain Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing a (more detail) 6 NA Homo sapiens
WAG000283
Cyclin E associated events during G1/S transition (more detail) 6 NA Homo sapiens
MEX001254
Genes associated with Kinase Inhibitor GW830263A Genes associated with Kinase Inhibitor GW830263A, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
MEX002266
Genes associated with Kinase Inhibitor CHEMBL272938 Genes associated with Kinase Inhibitor CHEMBL272938, curated by the Drug Signature Database (DSigDB) (more detail) 6 25990557 Homo sapiens
MEX002018
Genes associated with Kinase Inhibitor Wee1 Inhibitor Genes associated with Kinase Inhibitor Wee1 Inhibitor, curated by the Drug Signature Database (DSigD (more detail) 6 25990557 Homo sapiens
IEI014872
Protein protein interactors of human gene VGF from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene VGF (SwissProt ID=O1 (more detail) 6 17535438 Homo sapiens
TAX029119
GO:0070816 biological process phosphorylation of RNA polymerase II C terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of (more detail) 6 NA Homo sapiens
IEI004747
Protein protein interactors of human gene FGF5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene FGF5 (SwissProt ID=P (more detail) 6 17535438 Homo sapiens
TAX023876
GO:0042500 molecular function aspartic endopeptidase activity, intramembrane cleaving Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a (more detail) 6 NA Homo sapiens
TAX022752
GO:0035174 molecular function histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of (more detail) 6 NA Homo sapiens
TAX029759
GO:0071947 biological process protein deubiquitination involved in ubiquitin dependent protein catabolic process The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-depende (more detail) 6 NA Homo sapiens
TAX022915
GO:0035519 biological process protein K29 linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine (more detail) 6 NA Homo sapiens
WAG000263
Ras signaling in the CD4+ TCR pathway (more detail) 9 NA Homo sapiens
TAX034836
GO:2000644 biological process regulation of receptor catabolic process Any process that modulates the frequency, rate or extent of receptor catabolic process. (more detail) 9 NA Homo sapiens
IEI000385
Protein protein interactors of human gene AHCYL2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene AHCYL2 (SwissProt ID (more detail) 9 17535438 Homo sapiens
MEX002402
Genes associated with Kinase Inhibitor Lapatinib Genes associated with Kinase Inhibitor Lapatinib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
IEI004989
Protein protein interactors of human gene GAB3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GAB3 (SwissProt ID=Q (more detail) 9 17535438 Homo sapiens
MOX005434
Genes associated with Computational Drug Signature 1 NM PP1 Genes associated with Computational Drug Signature 1-NM-PP1, curated by the Drug Signature Database (more detail) 9 25990557 Homo sapiens
TAX022427
GO:0034350 biological process regulation of glial cell apoptotic process Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. (more detail) 9 NA Homo sapiens
MOX017130
Genes associated with Computational Drug Signature Ruxolitinib Genes associated with Computational Drug Signature Ruxolitinib, curated by the Drug Signature Databa (more detail) 9 25990557 Homo sapiens
IEI014238
Protein protein interactors of human gene TRIM34 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM34 (SwissProt ID (more detail) 9 17535438 Homo sapiens
MOX001810
Genes associated with Computational Drug Signature N Chlorothylnitrosourea sarcosinamide Genes associated with Computational Drug Signature N-Chlorothylnitrosourea sarcosinamide, curated by (more detail) 9 25990557 Homo sapiens
IEI006261
Protein protein interactors of human gene IGLC1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene IGLC1 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
IEI013066
Protein protein interactors of human gene STAB2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene STAB2 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
WAG000929
Removal of aminoterminal propeptides from gamma carboxylated proteins (more detail) 9 NA Homo sapiens
TAX016855
GO:0007220 biological process Notch receptor processing The series of successive proteolytic cleavages of the Notch protein, which result in an active form (more detail) 9 NA Homo sapiens
PEX001484
Rhodanese: Rhodanese like domain Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain (more detail) 9 NA Homo sapiens
IEI003981
Protein protein interactors of human gene EFNA4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EFNA4 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
TAX001019
Genes annotated by the GO term GO:0008287. A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. (more detail) 9 NA Homo sapiens
IEI004644
Protein protein interactors of human gene FBXO31 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene FBXO31 (SwissProt ID (more detail) 9 17535438 Homo sapiens
TAX022662
GO:0034770 biological process histone H4 K20 methylation The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of (more detail) 9 NA Homo sapiens
IEI004295
Protein protein interactors of human gene ESCO1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ESCO1 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
IEI005839
Protein protein interactors of human gene HIF3A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene HIF3A (SwissProt ID= (more detail) 9 17535438 Homo sapiens
TAX024814
GO:0044666 cellular component MLL3/4 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protei (more detail) 9 NA Homo sapiens
TAX026609
GO:0050812 biological process regulation of acyl CoA biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resu (more detail) 9 NA Homo sapiens
TAX032862
GO:1903265 biological process positive regulation of tumor necrosis factor mediated signaling pathway Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-media (more detail) 9 NA Homo sapiens
TAX019502
GO:0018230 biological process peptidyl L cysteine S palmitoylation The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form (more detail) 7 NA Homo sapiens
TAX013284
GO:0000160 biological process phosphorelay signal transduction system A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphoryl (more detail) 7 NA Homo sapiens
TAX016869
GO:0007256 biological process activation of JNKK activity The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are i (more detail) 7 NA Homo sapiens
MOX015199
Genes associated with Computational Drug Signature Staurosporine, N Benzoyl Genes associated with Computational Drug Signature Staurosporine, N-Benzoyl, curated by the Drug Sig (more detail) 7 25990557 Homo sapiens
MOX003409
Genes associated with Computational Drug Signature gw8510 Genes associated with Computational Drug Signature gw8510, curated by the Drug Signature Database (D (more detail) 7 25990557 Homo sapiens
MOX001703
Genes associated with Computational Drug Signature bafilomycin A1 Genes associated with Computational Drug Signature bafilomycin A1, curated by the Drug Signature Dat (more detail) 7 25990557 Homo sapiens
TAX019503
GO:0018231 biological process peptidyl S diacylglycerol L cysteine biosynthetic process from peptidyl cysteine The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and p (more detail) 7 NA Homo sapiens
TAX032022
GO:1901142 biological process insulin metabolic process The chemical reactions and pathways involving insulin. (more detail) 7 NA Homo sapiens
TAX021014
GO:0031466 cellular component Cul5 RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form (more detail) 7 NA Homo sapiens
MEX001399
Genes associated with Kinase Inhibitor MLS002232309 Genes associated with Kinase Inhibitor MLS002232309, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MOX012970
Genes associated with Computational Drug Signature gw8510 Genes associated with Computational Drug Signature gw8510, curated by the Drug Signature Database (D (more detail) 7 25990557 Homo sapiens
TAX034762
GO:2000544 biological process regulation of endothelial cell chemotaxis to fibroblast growth factor Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblas (more detail) 7 NA Homo sapiens
TAX033648
GO:1904847 biological process regulation of cell chemotaxis to fibroblast growth factor Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth fac (more detail) 7 NA Homo sapiens
TAX022823
GO:0035333 biological process Notch receptor processing, ligand dependent The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand bind (more detail) 7 NA Homo sapiens
TAX030298
GO:0090045 biological process positive regulation of deacetylase activity Any process that activates or increases the frequency, rate or extent of deacetylase activity, the c (more detail) 7 NA Homo sapiens
TAX032246
GO:1901725 biological process regulation of histone deacetylase activity Any process that modulates the frequency, rate or extent of histone deacetylase activity. (more detail) 7 NA Homo sapiens
IEI009682
Protein protein interactors of human gene PDGFC from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PDGFC (SwissProt ID= (more detail) 7 17535438 Homo sapiens
WAG000274
Classical antibody mediated complement activation (more detail) 5 NA Homo sapiens
MEX001448
Genes associated with Kinase Inhibitor GSK571989A Genes associated with Kinase Inhibitor GSK571989A, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001542
Genes associated with Kinase Inhibitor Kinome 3161 Genes associated with Kinase Inhibitor Kinome_3161, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001732
Genes associated with Kinase Inhibitor 3erk Genes associated with Kinase Inhibitor 3erk, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002070
Genes associated with Kinase Inhibitor Kinome 568 Genes associated with Kinase Inhibitor Kinome_568, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002184
Genes associated with Kinase Inhibitor CHEMBL394619 Genes associated with Kinase Inhibitor CHEMBL394619, curated by the Drug Signature Database (DSigDB) (more detail) 5 25990557 Homo sapiens
MOX007563
Genes associated with Computational Drug Signature CEP 6331 Genes associated with Computational Drug Signature CEP-6331, curated by the Drug Signature Database (more detail) 5 25990557 Homo sapiens
TAX018131
GO:0010815 biological process bradykinin catabolic process The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin. (more detail) 5 NA Homo sapiens
TAX025843
GO:0046974 molecular function histone methyltransferase activity (H3 K9 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L (more detail) 5 NA Homo sapiens
TAX015548
GO:0005007 molecular function fibroblast growth factor activated receptor activity Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to (more detail) 5 NA Homo sapiens
MEX001413
Genes associated with Kinase Inhibitor GW621970X Genes associated with Kinase Inhibitor GW621970X, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002227
Genes associated with Kinase Inhibitor CHEMBL404367 Genes associated with Kinase Inhibitor CHEMBL404367, curated by the Drug Signature Database (DSigDB) (more detail) 5 25990557 Homo sapiens
MEX001587
Genes associated with Kinase Inhibitor Kinome 312 Genes associated with Kinase Inhibitor Kinome_312, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001947
Genes associated with Kinase Inhibitor GW771127A Genes associated with Kinase Inhibitor GW771127A, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001677
Genes associated with Kinase Inhibitor GSK554170A Genes associated with Kinase Inhibitor GSK554170A, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002043
Genes associated with Kinase Inhibitor Src Kinase Inhibitor I Genes associated with Kinase Inhibitor Src Kinase Inhibitor I, curated by the Drug Signature Databas (more detail) 5 25990557 Homo sapiens
MEX001752
Genes associated with Kinase Inhibitor Kinome 1123 Genes associated with Kinase Inhibitor Kinome_1123, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002125
Genes associated with Kinase Inhibitor Kinome 126 Genes associated with Kinase Inhibitor Kinome_126, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002148
Genes associated with Kinase Inhibitor Kinome 1143 Genes associated with Kinase Inhibitor Kinome_1143, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002189
Genes associated with Kinase Inhibitor GDC 0879 Genes associated with Kinase Inhibitor GDC-0879, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
PEX002447
ERAP1 C: ERAP1 like C terminal domain This large domain is composed of 16 alpha helices organized as 8 HEAT-like repeats. This domain for (more detail) 5 NA Homo sapiens
MOX012427
Genes associated with Computational Drug Signature Dovitinib Genes associated with Computational Drug Signature Dovitinib, curated by the Drug Signature Database (more detail) 5 25990557 Homo sapiens
MEX001263
Genes associated with Kinase Inhibitor Kinome 2305 Genes associated with Kinase Inhibitor Kinome_2305, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001275
Genes associated with Kinase Inhibitor 405169 16 6 Genes associated with Kinase Inhibitor 405169-16-6, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001368
Genes associated with Kinase Inhibitor GW876790X Genes associated with Kinase Inhibitor GW876790X, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001714
Genes associated with Kinase Inhibitor GW770220A Genes associated with Kinase Inhibitor GW770220A, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001776
Genes associated with Kinase Inhibitor JNK Inhibitor V Genes associated with Kinase Inhibitor JNK Inhibitor V, curated by the Drug Signature Database (DSig (more detail) 5 25990557 Homo sapiens
MEX001822
Genes associated with Kinase Inhibitor Kinome 1140 Genes associated with Kinase Inhibitor Kinome_1140, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001529
Genes associated with Kinase Inhibitor GW833373X Genes associated with Kinase Inhibitor GW833373X, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002188
Genes associated with Kinase Inhibitor GSK2334470 Genes associated with Kinase Inhibitor GSK2334470, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
TAX016038
GO:0005964 cellular component phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. (more detail) 5 NA Homo sapiens
TAX015303
GO:0004661 molecular function protein geranylgeranyltransferase activity Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether li (more detail) 5 NA Homo sapiens
MOX014396
Genes associated with Computational Drug Signature PD173952 Genes associated with Computational Drug Signature PD173952, curated by the Drug Signature Database (more detail) 5 25990557 Homo sapiens
MOX014890
Genes associated with Computational Drug Signature RS 130830 Genes associated with Computational Drug Signature RS-130830, curated by the Drug Signature Database (more detail) 5 25990557 Homo sapiens
POX000463
PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 5 NA Homo sapiens
TAX031545
GO:0103068 molecular function leukotriene C4 gamma glutamyl transferase activity Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma (more detail) 5 NA Homo sapiens
MEX001360
Genes associated with Kinase Inhibitor Kinome 2119 Genes associated with Kinase Inhibitor Kinome_2119, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001596
Genes associated with Kinase Inhibitor Linifanib Genes associated with Kinase Inhibitor Linifanib, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002027
Genes associated with Kinase Inhibitor Cediranib Genes associated with Kinase Inhibitor Cediranib, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001733
Genes associated with Kinase Inhibitor genistein Genes associated with Kinase Inhibitor genistein, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001868
Genes associated with Kinase Inhibitor Kinome 436 Genes associated with Kinase Inhibitor Kinome_436, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MOX010000
Genes associated with Computational Drug Signature CHEMBL383990 Genes associated with Computational Drug Signature CHEMBL383990, curated by the Drug Signature Datab (more detail) 5 25990557 Homo sapiens
TAX022029
GO:0033192 molecular function calmodulin dependent protein phosphatase activity Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + pho (more detail) 5 NA Homo sapiens
PEX000357
F box like: F box like This is an F-box-like family. (more detail) 5 NA Homo sapiens
MOX015958
Genes associated with Computational Drug Signature ZK CDK Genes associated with Computational Drug Signature ZK CDK, curated by the Drug Signature Database (D (more detail) 5 25990557 Homo sapiens
MOX014385
Genes associated with Computational Drug Signature PD 0179483 Genes associated with Computational Drug Signature PD-0179483, curated by the Drug Signature Databas (more detail) 5 25990557 Homo sapiens
TAX031534
GO:0102953 molecular function hypoglycin A gamma glutamyl transpeptidase activity Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B (more detail) 5 NA Homo sapiens
MEX001315
Genes associated with Kinase Inhibitor Kinome 1318 Genes associated with Kinase Inhibitor Kinome_1318, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001656
Genes associated with Kinase Inhibitor Kinome 601 Genes associated with Kinase Inhibitor Kinome_601, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001681
Genes associated with Kinase Inhibitor N (2 (Diethylamino)ethyl) 5 ((5 fluoro 2 oxoindolin 3 ylidene)methyl) 2,4 dimethyl 1H pyrrole 3 carboxamide Genes associated with Kinase Inhibitor N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene (more detail) 5 25990557 Homo sapiens
MEX001722
Genes associated with Kinase Inhibitor AST 487 Genes associated with Kinase Inhibitor AST 487, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001506
Genes associated with Kinase Inhibitor Kinome 28 Genes associated with Kinase Inhibitor Kinome_28, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MOX002615
Genes associated with Computational Drug Signature 2,3,5 (Trigsyl)HQ Genes associated with Computational Drug Signature 2,3,5-(Trigsyl)HQ, curated by the Drug Signature (more detail) 5 25990557 Homo sapiens
TAX019534
GO:0018401 biological process peptidyl proline hydroxylation to 4 hydroxy L proline The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2 (more detail) 5 NA Homo sapiens
TAX025845
GO:0046976 molecular function histone methyltransferase activity (H3 K27 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl- (more detail) 5 NA Homo sapiens
TAX014855
GO:0003923 molecular function GPI anchor transamidase activity Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol ancho (more detail) 5 NA Homo sapiens
PEX000536
Gla: Vitamin K dependent carboxylation/gamma carboxyglutamic (GLA) domain This domain is responsible for the high-affinity binding of calcium ions. This domain contains pos (more detail) 5 NA Homo sapiens
PEX002171
SIR2: Sir2 family This region is characteristic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These (more detail) 5 NA Homo sapiens
PEX000875
BTK: BTK motif Zinc-binding motif containing conserved cysteines and a histidine. Always found C-terminal to PH dom (more detail) 5 NA Homo sapiens
MOX015916
Genes associated with Computational Drug Signature y 27632 Genes associated with Computational Drug Signature y-27632, curated by the Drug Signature Database ( (more detail) 5 25990557 Homo sapiens
POX000489
PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 5 NA Homo sapiens
MEX001969
Genes associated with Kinase Inhibitor SB 216763 Genes associated with Kinase Inhibitor SB 216763, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002383
Genes associated with Kinase Inhibitor Kinome 825 Genes associated with Kinase Inhibitor Kinome_825, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002051
Genes associated with Kinase Inhibitor 5 [5,6 Bis(Methyloxy) 1h Benzimidazol 1 Yl] 3 {[1 (2 Chlorophenyl)ethyl]oxy} 2 Thiophenecarboxamide Genes associated with Kinase Inhibitor 5-[5,6-Bis(Methyloxy)-1h-Benzimidazol-1-Yl]-3-{[1-(2-Chloroph (more detail) 5 25990557 Homo sapiens
MEX001483
Genes associated with Kinase Inhibitor IKK 3 Inhibitor Genes associated with Kinase Inhibitor IKK-3 Inhibitor, curated by the Drug Signature Database (DSig (more detail) 5 25990557 Homo sapiens
MOX008674
Genes associated with Computational Drug Signature CHEMBL206866 Genes associated with Computational Drug Signature CHEMBL206866, curated by the Drug Signature Datab (more detail) 5 25990557 Homo sapiens
MOX013152
Genes associated with Computational Drug Signature inositol 1,3,4,5 tetrakisphosphate Genes associated with Computational Drug Signature inositol 1,3,4,5-tetrakisphosphate, curated by th (more detail) 5 25990557 Homo sapiens
TAX018279
GO:0010994 biological process free ubiquitin chain polymerization The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin mon (more detail) 5 NA Homo sapiens
TAX031148
GO:0098821 molecular function BMP receptor activity Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal ac (more detail) 5 NA Homo sapiens
TAX015320
GO:0004689 molecular function phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. (more detail) 5 NA Homo sapiens
MEX001251
Genes associated with Kinase Inhibitor Canertinib Genes associated with Kinase Inhibitor Canertinib, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001298
Genes associated with Kinase Inhibitor Pazopanib Genes associated with Kinase Inhibitor Pazopanib, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX002001
Genes associated with Kinase Inhibitor ZM 336372 Genes associated with Kinase Inhibitor ZM 336372, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001810
Genes associated with Kinase Inhibitor GSK614526A Genes associated with Kinase Inhibitor GSK614526A, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001853
Genes associated with Kinase Inhibitor IRAK 1/4 Inhibitor Genes associated with Kinase Inhibitor IRAK-1/4 Inhibitor, curated by the Drug Signature Database (D (more detail) 5 25990557 Homo sapiens
MOX013280
Genes associated with Computational Drug Signature Kinome 3019 Genes associated with Computational Drug Signature Kinome_3019, curated by the Drug Signature Databa (more detail) 5 25990557 Homo sapiens
TAX022124
GO:0033503 cellular component HULC complex A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin (more detail) 5 NA Homo sapiens
MOX015016
Genes associated with Computational Drug Signature SB 747651A Genes associated with Computational Drug Signature SB-747651A, curated by the Drug Signature Databas (more detail) 5 25990557 Homo sapiens
MOX014451
Genes associated with Computational Drug Signature PHA 767491 Genes associated with Computational Drug Signature PHA-767491, curated by the Drug Signature Databas (more detail) 5 25990557 Homo sapiens
MOX014384
Genes associated with Computational Drug Signature PD 0173958 Genes associated with Computational Drug Signature PD-0173958, curated by the Drug Signature Databas (more detail) 5 25990557 Homo sapiens
MEX001929
Genes associated with Kinase Inhibitor GW654652C Genes associated with Kinase Inhibitor GW654652C, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001631
Genes associated with Kinase Inhibitor Kinome 1106 Genes associated with Kinase Inhibitor Kinome_1106, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001665
Genes associated with Kinase Inhibitor Kinome 857 Genes associated with Kinase Inhibitor Kinome_857, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001711
Genes associated with Kinase Inhibitor Kinome 1107 Genes associated with Kinase Inhibitor Kinome_1107, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MEX001759
Genes associated with Kinase Inhibitor Kinome 2098 Genes associated with Kinase Inhibitor Kinome_2098, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
MOX005931
Genes associated with Computational Drug Signature 303727 31 3 Genes associated with Computational Drug Signature 303727-31-3, curated by the Drug Signature Databa (more detail) 5 25990557 Homo sapiens
MOX007353
Genes associated with Computational Drug Signature Boceprevir Genes associated with Computational Drug Signature Boceprevir, curated by the Drug Signature Databas (more detail) 5 25990557 Homo sapiens
TAX017350
GO:0008568 molecular function microtubule severing ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule a (more detail) 5 NA Homo sapiens
TAX019308
GO:0016929 molecular function SUMO specific protease activity Catalysis of the hydrolysis of peptide or isopeptide bonds within SUMO, or between the SUMO and a la (more detail) 5 NA Homo sapiens
MOX015688
Genes associated with Computational Drug Signature UK 356618 Genes associated with Computational Drug Signature UK-356618, curated by the Drug Signature Database (more detail) 5 25990557 Homo sapiens
TAX024006
GO:0042765 cellular component GPI anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the com (more detail) 5 NA Homo sapiens
TAX028745
GO:0070122 molecular function isopeptidase activity Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a (more detail) 5 NA Homo sapiens
TAX028532
GO:0061665 molecular function SUMO ligase activity Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, (more detail) 5 NA Homo sapiens
TAX022979
GO:0035610 biological process protein side chain deglutamylation The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added (more detail) 5 NA Homo sapiens
TAX029537
GO:0071558 molecular function histone demethylase activity (H3 K27 specific) Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein. (more detail) 5 NA Homo sapiens
TAX024025
GO:0042799 molecular function histone methyltransferase activity (H4 K20 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl- (more detail) 5 NA Homo sapiens
TAX023210
GO:0036021 cellular component endolysosome lumen The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organe (more detail) 5 NA Homo sapiens
IEI004560
Protein protein interactors of human gene FAM9A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene FAM9A (SwissProt ID= (more detail) 5 17535438 Homo sapiens
TAX022978
GO:0035609 biological process C terminal protein deglutamylation The removal of a C-terminal, gene-encoded glutamate residue from a protein. (more detail) 5 NA Homo sapiens
TAX029671
GO:0071797 cellular component LUBAC complex A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targe (more detail) 5 NA Homo sapiens
TAX024682
GO:0044314 biological process protein K27 linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine (more detail) 5 NA Homo sapiens
WEX000004
Angiotensin System The genes related to angiotensin system (physiology & disease) in tumor using next-generation sequen (more detail) 5 NA Homo sapiens
TAX029536
GO:0071557 biological process histone H3 K27 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the hi (more detail) 5 NA Homo sapiens
TAX030056
GO:0072557 cellular component IPAF inflammasome complex A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among it (more detail) 5 NA Homo sapiens
WAG000300
Gamma carboxylation, transport, and amino terminal cleavage of proteins (more detail) 8 NA Homo sapiens
TAX021983
GO:0033129 biological process positive regulation of histone phosphorylation Any process that activates or increases the frequency, rate or extent of the addition of one or more (more detail) 8 NA Homo sapiens
TAX027613
GO:0060020 biological process Bergmann glial cell differentiation The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, spec (more detail) 8 NA Homo sapiens
TAX021236
GO:0031937 biological process positive regulation of chromatin silencing Any process that activates or increases the frequency, rate or extent of chromatin silencing. (more detail) 8 NA Homo sapiens
MOX012657
Genes associated with Computational Drug Signature Fasudil Genes associated with Computational Drug Signature Fasudil, curated by the Drug Signature Database ( (more detail) 8 25990557 Homo sapiens
MOX002219
Genes associated with Computational Drug Signature Fosbretabulin Genes associated with Computational Drug Signature Fosbretabulin, curated by the Drug Signature Data (more detail) 8 25990557 Homo sapiens
MOX000603
Genes associated with Computational Drug Signature phytosphingosine Genes associated with Computational Drug Signature phytosphingosine, curated by the Drug Signature D (more detail) 8 25990557 Homo sapiens
MOX004149
Genes associated with Computational Drug Signature GLYCOCHENODEOXYCHOLIC ACID Genes associated with Computational Drug Signature GLYCOCHENODEOXYCHOLIC ACID, curated by the Drug S (more detail) 8 25990557 Homo sapiens
MOX003200
Genes associated with Computational Drug Signature Canertinib dihydrochloride Genes associated with Computational Drug Signature Canertinib dihydrochloride, curated by the Drug S (more detail) 8 25990557 Homo sapiens
MOX002297
Genes associated with Computational Drug Signature Dexanabinol Genes associated with Computational Drug Signature Dexanabinol, curated by the Drug Signature Databa (more detail) 8 25990557 Homo sapiens
TAX013418
GO:0000439 cellular component core TFIIH complex The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or (more detail) 8 NA Homo sapiens
MAX000765
Genes required for both proliferation and CTNNB1 [GeneID=1499] activity in DLD 1 cell (colon cancer with APC [GeneID=324] deletions). Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancer (more detail) 8 NA Homo sapiens
MOX006911
Genes associated with Computational Drug Signature ALOISINE A Genes associated with Computational Drug Signature ALOISINE A, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
WAG000128
Transport of gamma carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus (more detail) 8 NA Homo sapiens
MOX004579
Genes associated with Computational Drug Signature Prodigiosin Genes associated with Computational Drug Signature Prodigiosin, curated by the Drug Signature Databa (more detail) 8 25990557 Homo sapiens
MOX012534
Genes associated with Computational Drug Signature Entinostat Genes associated with Computational Drug Signature Entinostat, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
IEI013148
Protein protein interactors of human gene STRADB from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene STRADB (SwissProt ID (more detail) 8 17535438 Homo sapiens
IEI009742
Protein protein interactors of human gene PEG3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PEG3 (SwissProt ID=Q (more detail) 8 17535438 Homo sapiens
IEI012926
Protein protein interactors of human gene SPRY4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SPRY4 (SwissProt ID= (more detail) 8 17535438 Homo sapiens
IEI009053
Protein protein interactors of human gene NRG1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NRG1 (SwissProt ID=Q (more detail) 8 17535438 Homo sapiens
IEI005132
Protein protein interactors of human gene GDF5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GDF5 (SwissProt ID=P (more detail) 8 17535438 Homo sapiens
TAX023188
GO:0035988 biological process chondrocyte proliferation The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of t (more detail) 8 NA Homo sapiens
IEI008089
Protein protein interactors of human gene MOB3A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MOB3A (SwissProt ID= (more detail) 8 17535438 Homo sapiens
TAX022428
GO:0034351 biological process negative regulation of glial cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic (more detail) 8 NA Homo sapiens
TAX032372
GO:1902101 biological process positive regulation of metaphase/anaphase transition of cell cycle Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transiti (more detail) 8 NA Homo sapiens
TAX029093
GO:0070734 biological process histone H3 K27 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of (more detail) 8 NA Homo sapiens
MOX002472
Genes associated with Computational Drug Signature 2' Cyano 2' deoxyarabinofuranosylcytosine Genes associated with Computational Drug Signature 2'-Cyano-2'-deoxyarabinofuranosylcytosine, curate (more detail) 6 25990557 Homo sapiens
MOX005984
Genes associated with Computational Drug Signature 4 (2 Oxo 2 phenyl acetyl) benzoic acid Genes associated with Computational Drug Signature 4-(2-Oxo-2-phenyl-acetyl)-benzoic acid, curated b (more detail) 6 25990557 Homo sapiens
PEX002739
Peptidase S9: Prolyl oligopeptidase family (more detail) 6 NA Homo sapiens
TAX018939
GO:0016255 biological process attachment of GPI anchor to protein A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant (more detail) 6 NA Homo sapiens
MOX000952
Genes associated with Computational Drug Signature tiaprofenic acid Genes associated with Computational Drug Signature tiaprofenic acid, curated by the Drug Signature D (more detail) 6 25990557 Homo sapiens
MAX002162
Candidate substrate proteins of AURKA [GeneID=6790] . Mammalian Aurora-A is related to a serine/threonine protein kinase that was originally identified by (more detail) 6 NA Homo sapiens
MOX007373
Genes associated with Computational Drug Signature Brivanib Genes associated with Computational Drug Signature Brivanib, curated by the Drug Signature Database (more detail) 6 25990557 Homo sapiens
MOX003598
Genes associated with Computational Drug Signature pycnidione Genes associated with Computational Drug Signature pycnidione, curated by the Drug Signature Databas (more detail) 6 25990557 Homo sapiens
MOX014309
Genes associated with Computational Drug Signature Oxyresveratrol Genes associated with Computational Drug Signature Oxyresveratrol, curated by the Drug Signature Dat (more detail) 6 25990557 Homo sapiens
PEX001071
Peptidase M28: Peptidase family M28 (more detail) 6 NA Homo sapiens
TAX019524
GO:0018344 biological process protein geranylgeranylation The covalent attachment of a geranylgeranyl group to a protein. (more detail) 6 NA Homo sapiens
MEX001959
Genes associated with Kinase Inhibitor MLN 120B Genes associated with Kinase Inhibitor MLN-120B, curated by the Drug Signature Database (DSigDB). (more detail) 6 25990557 Homo sapiens
WAG000008
cbl mediated ligand induced downregulation of egf receptors pathway As with many cell-surface receptors, activation of the EGF receptor can result in receptor interliza (more detail) 6 NA Homo sapiens
MOX014509
Genes associated with Computational Drug Signature phosphothreonine Genes associated with Computational Drug Signature phosphothreonine, curated by the Drug Signature D (more detail) 6 25990557 Homo sapiens
PEX001002
Kringle: Kringle domain Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipop (more detail) 6 NA Homo sapiens
MOX009915
Genes associated with Computational Drug Signature CHEMBL378903 Genes associated with Computational Drug Signature CHEMBL378903, curated by the Drug Signature Datab (more detail) 6 25990557 Homo sapiens
MOX015542
Genes associated with Computational Drug Signature tiaprofenic acid Genes associated with Computational Drug Signature tiaprofenic acid, curated by the Drug Signature D (more detail) 6 25990557 Homo sapiens
MOX014326
Genes associated with Computational Drug Signature p38 MAP Kinase Inhibitor III Genes associated with Computational Drug Signature p38 MAP Kinase Inhibitor III, curated by the Drug (more detail) 6 25990557 Homo sapiens
WAG000633
deregulation of cdk5 in alzheimers disease Cyclin-dependent kise 5 (cdk5), a multi-functiol kise, and its neuron-specific activator p35 are req (more detail) 6 NA Homo sapiens
MOX000407
Genes associated with Computational Drug Signature phosphoramidon Genes associated with Computational Drug Signature phosphoramidon, curated by the Drug Signature Dat (more detail) 6 25990557 Homo sapiens
MOX013575
Genes associated with Computational Drug Signature Marimastat Genes associated with Computational Drug Signature Marimastat, curated by the Drug Signature Databas (more detail) 6 25990557 Homo sapiens
TAX021287
GO:0032020 biological process ISG15 protein conjugation The covalent addition to a protein of ISG15, a ubiquitin-like protein. (more detail) 6 NA Homo sapiens
PEX002377
PrmA: Ribosomal protein L11 methyltransferase (PrmA) This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences. (more detail) 6 NA Homo sapiens
TAX020698
GO:0030891 cellular component VCB complex A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for e (more detail) 6 NA Homo sapiens
IEI013520
Protein protein interactors of human gene TCTEX1D4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TCTEX1D4 (SwissProt (more detail) 6 17535438 Homo sapiens
IEI009732
Protein protein interactors of human gene PDZRN3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PDZRN3 (SwissProt ID (more detail) 6 17535438 Homo sapiens
TAX030721
GO:0097169 cellular component AIM2 inflammasome complex A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein (more detail) 6 NA Homo sapiens
IEI012247
Protein protein interactors of human gene SIX4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SIX4 (SwissProt ID=Q (more detail) 6 17535438 Homo sapiens
IEI001449
Protein protein interactors of human gene BRSK1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene BRSK1 (SwissProt ID= (more detail) 6 17535438 Homo sapiens
IEI010761
Protein protein interactors of human gene PTPRR from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PTPRR (SwissProt ID= (more detail) 6 17535438 Homo sapiens
IEI011644
Protein protein interactors of human gene RRP8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RRP8 (SwissProt ID=O (more detail) 6 17535438 Homo sapiens
IEI011139
Protein protein interactors of human gene RCOR2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RCOR2 (SwissProt ID= (more detail) 6 17535438 Homo sapiens
WEX000017
Cytotoxicity The genes related to cytotoxicity (immune response) in immune using next-generation sequencer (NGS) (more detail) 6 NA Homo sapiens
IEI015628
Protein protein interactors of human gene ZNF57 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ZNF57 (SwissProt ID= (more detail) 6 17535438 Homo sapiens
TAX030843
GO:0097413 cellular component Lewy body Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosp (more detail) 6 NA Homo sapiens
TAX029475
GO:0071458 cellular component integral component of cytoplasmic side of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate o (more detail) 6 NA Homo sapiens
IEI014328
Protein protein interactors of human gene TRPS1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRPS1 (SwissProt ID= (more detail) 6 17535438 Homo sapiens
TAX028758
GO:0070141 biological process response to UV A Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 6 NA Homo sapiens
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GOA 
