PAGER3: A Pathways, Annotated-lists and Gene signatures Electronic Repository Version 3

Query: molecular_function ligase activity

Result Filters

Size of PAGs

Min

Max

Species

Data Source

PAGs related to the disease: 156 PAGs

PAG ID	PAG Type	PAG Name	Size	Pubmed Reference	Organism	Data source	cohension

The M-type PAG-PAG relationships

Network Visualization

PAG_A	PAG_A_SIZE	PAG_B	PAG_B_SIZE	Overlap	Similarity score	LOGCDF

The R-type PAG-PAG relationships

Network Visualization

PAG_A	PAG_B	Total	PAG_A_OUT	PAG_B_IN	A regulate B	LOGCDF

E1-ubiquitin + AMP + PPi, where the E1-ubiquitin (more detail) 5 NA Homo sapiens

GOA TAX016332 GO:0006432 biological process phenylalanyl tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetas (more detail) 5 NA Homo sapiens

GOA TAX017669 GO:0009374 molecular function biotin binding Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline (more detail) 5 NA Homo sapiens

GOA TAX015421 GO:0004826 molecular function phenylalanine tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tR (more detail) 5 NA Homo sapiens

GOA TAX016222 GO:0006273 biological process lagging strand elongation The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongati (more detail) 6 NA Homo sapiens

GOA TAX031579 GO:0106074 biological process aminoacyl tRNA metabolism involved in translational fidelity Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or r (more detail) 8 NA Homo sapiens

GOA TAX014096 GO:0002161 molecular function aminoacyl tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA. (more detail) 8 NA Homo sapiens

GOA TAX019456 GO:0018094 biological process protein polyglycylation The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid. (more detail) 4 NA Homo sapiens

GOA TAX029094 GO:0070735 molecular function protein glycine ligase activity Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate (more detail) 4 NA Homo sapiens

GOA PEX001691 CPSase L D2: Carbamoyl phosphate synthase L chain, ATP binding domain Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from gluta (more detail) 4 NA Homo sapiens

Pfam TAX019279 GO:0016882 molecular function cyclo ligase activity Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming (more detail) 4 NA Homo sapiens

GOA TAX017661 GO:0009328 cellular component phenylalanine tRNA ligase complex An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl- (more detail) 4 NA Homo sapiens

GOA TAX022367 GO:0034201 biological process response to oleic acid Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 6 NA Homo sapiens

GOA TAX029070 GO:0070681 biological process glutaminyl tRNAGln biosynthesis via transamidation A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pat (more detail) 3 NA Homo sapiens

GOA TAX020419 GO:0030272 molecular function 5 formyltetrahydrofolate cyclo ligase activity Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H( (more detail) 3 NA Homo sapiens

GOA TAX026475 GO:0050567 molecular function glutaminyl tRNA synthase (glutamine hydrolyzing) activity Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gl (more detail) 3 NA Homo sapiens

GOA TAX020736 GO:0030956 cellular component glutamyl tRNA(Gln) amidotransferase complex A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates (more detail) 3 NA Homo sapiens

GOA POX000299 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 3 NA Homo sapiens

Isozyme POX000347 PathwayGeneSet, HumanCyc Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 3 NA Homo sapiens

Isozyme PEX000906 GATase: Glutamine amidotransferase class I (more detail) 3 NA Homo sapiens

Pfam TAX015380 GO:0004775 molecular function succinate CoA ligase (ADP forming) activity Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. (more detail) 3 NA Homo sapiens

GOA TAX019277 GO:0016880 molecular function acid ammonia (or amide) ligase activity Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with t (more detail) 3 NA Homo sapiens

GOA TAX014895 GO:0003987 molecular function acetate CoA ligase activity Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. (more detail) 3 NA Homo sapiens

GOA POX000371 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 3 NA Homo sapiens

Isozyme WAG000496 Glutathione synthesis (more detail) 3 NA Homo sapiens

Reactome TAX015379 GO:0004774 molecular function succinate CoA ligase activity Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phos (more detail) 3 NA Homo sapiens

GOA TAX014960 GO:0004075 molecular function biotin carboxylase activity Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybi (more detail) 3 NA Homo sapiens

GOA PEX000958 DNA ligase A N: DNA ligase N terminus This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1). It is thoug (more detail) 3 NA Homo sapiens

Pfam POX000282 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 3 NA Homo sapiens

Isozyme MOX014434 Genes associated with Computational Drug Signature Pevonedistat Genes associated with Computational Drug Signature Pevonedistat, curated by the Drug Signature Datab (more detail) 3 25990557 Homo sapiens

DSigDB PEX001133 DNA ligase A C: ATP dependent DNA ligase C terminal region This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1). It is thou (more detail) 3 NA Homo sapiens

Pfam PEX001079 PARP reg: Poly(ADP ribose) polymerase, regulatory domain Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itsel (more detail) 3 NA Homo sapiens

Pfam PEX001933 DNA ligase A M: ATP dependent DNA ligase domain This domain belongs to a more diverse superfamily, including Pfam:PF01331 and Pfam:PF01653 3. (more detail) 3 NA Homo sapiens

Pfam FOX000660 Genes in the cancer module 35 (more detail) 4 NA Homo sapiens

MSigDB TAX035153 GO:2001295 biological process malonyl CoA biosynthetic process The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivat (more detail) 2 NA Homo sapiens

GOA TAX019890 GO:0019948 molecular function SUMO activating enzyme activity Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, (more detail) 2 NA Homo sapiens

GOA TAX019754 GO:0019542 biological process propionate biosynthetic process The chemical reactions and pathways resulting in the formation of propionate, the anion derived from (more detail) 2 NA Homo sapiens

GOA TAX033424 GO:1904387 biological process cellular response to L phenylalanine derivative Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 2 NA Homo sapiens

GOA TAX034233 GO:1990404 molecular function protein ADP ribosylase activity The transfer, from NAD, of ADP-ribose to a protein amino acid residue. (more detail) 2 NA Homo sapiens

GOA TAX030473 GO:0090298 biological process negative regulation of mitochondrial DNA replication Any process that decreases the rate, frequency or extent of the process in which new strands of DNA (more detail) 2 NA Homo sapiens

GOA TAX030667 GO:0097069 biological process cellular response to thyroxine stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene ex (more detail) 2 NA Homo sapiens

GOA TAX024831 GO:0044752 biological process response to human chorionic gonadotropin Any process that results in a change in state or activity of a cell or organism (in terms of movemen (more detail) 2 NA Homo sapiens

GOA TAX019809 GO:0019781 molecular function NEDD8 activating enzyme activity Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade. (more detail) 2 NA Homo sapiens

GOA TAX019384 GO:0017109 cellular component glutamate cysteine ligase complex An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine. (more detail) 2 NA Homo sapiens

GOA TAX029095 GO:0070736 molecular function protein glycine ligase activity, initiating Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of o (more detail) 2 NA Homo sapiens

GOA TAX032280 GO:1901859 biological process negative regulation of mitochondrial DNA metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metab (more detail) 2 NA Homo sapiens

GOA TAX032985 GO:1903518 biological process positive regulation of single strand break repair Any process that activates or increases the frequency, rate or extent of single strand break repair. (more detail) 2 NA Homo sapiens

GOA TAX030078 GO:0072590 molecular function N acetyl L aspartate L glutamate ligase activity Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspa (more detail) 2 NA Homo sapiens

GOA TAX024624 GO:0044210 biological process 'de novo' CTP biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) fro (more detail) 2 NA Homo sapiens

GOA TAX033818 GO:1905202 cellular component methylcrotonoyl CoA carboxylase complex A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity. (more detail) 2 NA Homo sapiens

GOA MOX009904 Genes associated with Computational Drug Signature CHEMBL378186 Genes associated with Computational Drug Signature CHEMBL378186, curated by the Drug Signature Datab (more detail) 2 25990557 Homo sapiens

DSigDB TAX015083 GO:0004356 molecular function glutamate ammonia ligase activity Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate. (more detail) 2 NA Homo sapiens

GOA TAX014880 GO:0003963 molecular function RNA 3' phosphate cyclase activity Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'- (more detail) 2 NA Homo sapiens

GOA POX000163 PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme TAX016320 GO:0006420 biological process arginyl tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl- (more detail) 2 NA Homo sapiens

GOA TAX016321 GO:0006421 biological process asparaginyl tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. Th (more detail) 2 NA Homo sapiens

GOA MOX012075 Genes associated with Computational Drug Signature CP 640186 Genes associated with Computational Drug Signature CP-640186, curated by the Drug Signature Database (more detail) 2 25990557 Homo sapiens

DSigDB TAX013714 GO:0001579 biological process medium chain fatty acid transport The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, b (more detail) 2 NA Homo sapiens

GOA TAX015165 GO:0004485 molecular function methylcrotonoyl CoA carboxylase activity Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-Co (more detail) 2 NA Homo sapiens

GOA PEX001270 Biotin carb C: Biotin carboxylase C terminal domain Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalys (more detail) 2 NA Homo sapiens

Pfam PEX000599 Carboxyl trans: Carboxyl transferase domain All of the members in this family are biotin dependent carboxylases. The carboxyl transferase domai (more detail) 2 NA Homo sapiens

Pfam PEX002329 WGR: WGR domain This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism r (more detail) 2 NA Homo sapiens

Pfam POX000073 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme TAX015381 GO:0004776 molecular function succinate CoA ligase (GDP forming) activity Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. (more detail) 2 NA Homo sapiens

GOA TAX016409 GO:0006542 biological process glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbuta (more detail) 2 NA Homo sapiens

GOA TAX019717 GO:0019413 biological process acetate biosynthetic process The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. (more detail) 2 NA Homo sapiens

GOA TAX015408 GO:0004813 molecular function alanine tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). (more detail) 2 NA Homo sapiens

GOA TAX015060 GO:0004329 molecular function formate tetrahydrofolate ligase activity Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrof (more detail) 2 NA Homo sapiens

GOA PEX000442 zf PARP: Poly(ADP ribose) polymerase and DNA Ligase Zn finger region Poly(ADP-ribose) polymerase is an important regulatory component of the cellular response to DNA dam (more detail) 2 NA Homo sapiens

Pfam PEX000004 CTP synth N: CTP synthase N terminus This family consists of the N-terminal region of the CTP synthase protein (EC:6.3.4.2). This family (more detail) 2 NA Homo sapiens

Pfam POX000056 PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme TAX016319 GO:0006419 biological process alanyl tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA (more detail) 2 NA Homo sapiens

GOA TAX014971 GO:0004088 molecular function carbamoyl phosphate synthase (glutamine hydrolyzing) activity Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamo (more detail) 2 NA Homo sapiens

GOA PEX001124 ACC central: Acetyl CoA carboxylase, central region The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-termina (more detail) 2 NA Homo sapiens

Pfam PEX001152 tRNA synt 2d: tRNA synthetases class II core domain (F) Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phe (more detail) 2 NA Homo sapiens

Pfam POX000099 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme TAX016396 GO:0006529 biological process asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpro (more detail) 2 NA Homo sapiens

GOA TAX017634 GO:0009257 biological process 10 formyltetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the for (more detail) 2 NA Homo sapiens

GOA TAX019720 GO:0019427 biological process acetyl CoA biosynthetic process from acetate The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either di (more detail) 2 NA Homo sapiens

GOA TAX014098 GO:0002169 cellular component 3 methylcrotonyl CoA carboxylase complex, mitochondrial A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In ma (more detail) 2 NA Homo sapiens

GOA TAX015409 GO:0004814 molecular function arginine tRNA ligase activity Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). (more detail) 2 NA Homo sapiens

GOA POX000262 PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme POX000203 PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme TAX014970 GO:0004087 molecular function carbamoyl phosphate synthase (ammonia) activity Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + (more detail) 2 NA Homo sapiens

GOA TAX014897 GO:0003989 molecular function acetyl CoA carboxylase activity Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. (more detail) 2 NA Homo sapiens

GOA TAX015084 GO:0004357 molecular function glutamate cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H( (more detail) 2 NA Homo sapiens

GOA TAX014833 GO:0003883 molecular function CTP synthase activity Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. (more detail) 2 NA Homo sapiens

GOA POX000176 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme POX000085 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme POX000035 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme TAX014954 GO:0004066 molecular function asparagine synthase (glutamine hydrolyzing) activity Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-gl (more detail) 2 NA Homo sapiens

GOA MOX004708 Genes associated with Computational Drug Signature suprofen Genes associated with Computational Drug Signature suprofen, curated by the Drug Signature Database (more detail) 2 25990557 Homo sapiens

DSigDB POX000268 IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 2 NA Homo sapiens

Isozyme PEX002708 Biotin carb N: Biotin carboxylase, N terminal domain This domain is structurally related to the PreATP-grasp domain. The family contains the N-terminus o (more detail) 2 NA Homo sapiens

Pfam PEX001373 tRNA synt 1b: tRNA synthetases class I (W and Y) (more detail) 2 NA Homo sapiens

Pfam PEX000644 AMP binding C: AMP binding enzyme C terminal domain This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core th (more detail) 2 NA Homo sapiens

Pfam TAX015300 GO:0004658 molecular function propionyl CoA carboxylase activity Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. (more detail) 2 NA Homo sapiens

GOA TAX018913 GO:0016211 molecular function ammonia ligase activity Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with conc (more detail) 2 NA Homo sapiens