WIPER

WIPER: Weighted in-path edge ranking for biomolecular association networks
WIPER (Weighted in-Path Edge Ranking) is a new computational technique to help biomedical researchers prioritize both statistically and biologically significant biomolecular associations in disease-specific biomolecular association networks. (Read more)

web services
The web service is under construction, we will release it once been tested to be fully functional. However, we have provide the API service as follows.
API services
You can access the service using R, python, or other third party software (postman) using "post" method.
The simple access using python codes as follows:

import requests
import json
class WiperApi():
def __init__(self):
self.postContent = dict()
self.result = ''
def get_result(self,**kwargs):
self.postContent = kwargs['postContent'] if 'postContent' in kwargs.keys() else ''
r = requests.post('http://discovery.informatics.uab.edu/WIPER/index.php/pages/wiperApi', data = self.postContent)
self.result = json.loads(r.text)
wiper = WiperApi()
wiper.get_result(postContent = {"interaction": 'a b 0.9 b c 0.9 c a 0.9',"sigma": "0.8","ppicutoff": "0.1","pathLengthCutoff":"10","method": "ant","iteration": "2"})
print(wiper.result)

library(biomaRt)
library(jsonlite)
library(httr)
contnt <- list(
interaction='a b 0.9 b c 0.9 c a 0.9',
sigma="0.2",
ppicutoff="0.2",
pathLengthCutoff="10",
method="ant",
iteration="2"
)
req <- httr::POST("http://discovery.informatics.uab.edu/WIPER/index.php/pages/wiperApi",
body=contnt
);
json <- httr::content(req, as = "text")
WIPERresult=fromJSON(json, flatten = TRUE)

Parameters	Description
Interaction	A list of the edges consists of "nodeA", "nodeB", and "edge confidant score". The elements and edges are seperated by space.
Sigma	A damping factor is in a range of [0,1] to determine the probability of probability of a node continue in an information flow.
PPIcutoff	The threshold of edge confidant score is in a range of [0,1] to remove the lower confidant (protein protein interactions) PPIs and traversal paths.
Method	"ant" represents the ant colony algorithm described in the paper "WIPER: Weighted in-path edge ranking for biomolecular association networks". 'page' represents a page-rank algorithm
pathLengthCutoff	The default path length cutoff is infinity. Only those traversal path length no larger than the path length cutoff will be considerated in the edge-to-edge network.
Iterations	The default iteration is 200 in the paper method.

WIPER: Weighted in-path edge ranking for biomolecular association networks

web services

API services