PAGER3: A Pathways, Annotated-lists and Gene signatures Electronic Repository Version 3

Query: Melanoma

Result Filters

Size of PAGs

Min

Max

Species

Data Source

PAGs related to the disease: 430 PAGs

PAG ID	PAG Type	PAG Name	Size	Pubmed Reference	Organism	Data source	cohension

The M-type PAG-PAG relationships

Network Visualization

PAG_A	PAG_A_SIZE	PAG_B	PAG_B_SIZE	Overlap	Similarity score	LOGCDF

The R-type PAG-PAG relationships

Network Visualization

PAG_A	PAG_B	Total	PAG_A_OUT	PAG_B_IN	A regulate B	LOGCDF

X + S-NED (more detail) 1 NA Homo sapiens

GOA TAX034053 GO:1905776 biological process positive regulation of DNA helicase activity Any process that activates or increases the frequency, rate or extent of DNA helicase activity. (more detail) 1 NA Homo sapiens

GOA TAX027865 GO:0060380 biological process regulation of single stranded telomeric DNA binding Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA (more detail) 1 NA Homo sapiens

GOA TAX013459 GO:0000717 biological process nucleotide excision repair, DNA duplex unwinding The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DN (more detail) 1 NA Homo sapiens

GOA MOX012425 Genes associated with Computational Drug Signature Dotac compound Genes associated with Computational Drug Signature Dotac compound, curated by the Drug Signature Dat (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX012157 Genes associated with Computational Drug Signature Dabrafenib Genes associated with Computational Drug Signature Dabrafenib, curated by the Drug Signature Databas (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX014564 Genes associated with Computational Drug Signature PLSQETFSDLWKLLPEN NH2 Genes associated with Computational Drug Signature PLSQETFSDLWKLLPEN-NH2, curated by the Drug Signat (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX014934 Genes associated with Computational Drug Signature S Benzyl L cysteine Genes associated with Computational Drug Signature S-Benzyl-L-cysteine, curated by the Drug Signatur (more detail) 1 25990557.0 Homo sapiens

DSigDB IEI009449 Protein protein interactors of human gene PAGE5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PAGE5 (SwissProt ID= (more detail) 1 17535438 Homo sapiens

I2D IEI009771 Protein protein interactors of human gene PEX5L from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PEX5L (SwissProt ID= (more detail) 1 17535438 Homo sapiens

I2D IEI003599 Protein protein interactors of human gene DLX1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DLX1 (SwissProt ID=P (more detail) 1 17535438 Homo sapiens

I2D IEI005677 Protein protein interactors of human gene H2BW2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene H2BW2 (SwissProt ID= (more detail) 1 17535438 Homo sapiens

I2D IEI000278 Protein protein interactors of human gene ADGRF3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ADGRF3 (SwissProt ID (more detail) 1 17535438 Homo sapiens

I2D TAX031460 GO:0100002 biological process negative regulation of protein kinase activity by protein phosphorylation Any protein phosphorylation process that negatively_regulates protein kinase activity (more detail) 1 NA Homo sapiens

GOA TAX013259 GO:0000111 cellular component nucleotide excision repair factor 2 complex One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA bindi (more detail) 1 NA Homo sapiens

GOA WAG000891 MRN complex relocalizes to nuclear foci (more detail) 1 NA Homo sapiens

Reactome GEX000998 leukemia; noonan syndrome leukemia; noonan syndrome associated genes. PAGER constructed this gene set by grouping all genes wh (more detail) 1 NA Homo sapiens

GAD NAX005961 RAD50 (more detail) 1 NA Homo sapiens

Genome Data NAX004197 CYSLTR2 (more detail) 1 NA Homo sapiens

Genome Data NAX007407 RAD51C (more detail) 1 NA Homo sapiens

Genome Data NAX008278 MITF (more detail) 1 NA Homo sapiens

Genome Data NAX005109 PIK3CA (more detail) 1 NA Homo sapiens

Genome Data NAX006496 HRAS (more detail) 1 NA Homo sapiens

Genome Data NAX012217 BAP1 (more detail) 1 NA Homo sapiens

Genome Data NAX014424 RAD51 (more detail) 1 NA Homo sapiens

Genome Data NAX016986 SF3B1 (more detail) 1 NA Homo sapiens

Genome Data MOX000750 Genes associated with Computational Drug Signature Dabequin Genes associated with Computational Drug Signature Dabequin, curated by the Drug Signature Database (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX004403 Genes associated with Computational Drug Signature Neocarzinostatin (JAN) Genes associated with Computational Drug Signature Neocarzinostatin (JAN), curated by the Drug Signa (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX003537 Genes associated with Computational Drug Signature 1 (4 chlorobenzyl) 1H indole 3 carbaldehyde Genes associated with Computational Drug Signature 1-(4-chlorobenzyl)-1H-indole-3-carbaldehyde, cura (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX001526 Genes associated with Computational Drug Signature 2 AMINO 4,6 DINITROTOLUENE Genes associated with Computational Drug Signature 2-AMINO-4,6-DINITROTOLUENE, curated by the Drug S (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX006271 Genes associated with Computational Drug Signature 6 Benzyloxy 5 nitroso pyrimidine 2,4 diamine Genes associated with Computational Drug Signature 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine, cur (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX006320 Genes associated with Computational Drug Signature 7,8,3',4' tetrahydroxyflavone Genes associated with Computational Drug Signature 7,8,3',4'-tetrahydroxyflavone, curated by the Dru (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX005601 Genes associated with Computational Drug Signature 2,7 Bis(phenylacetamido)anthraquinone Genes associated with Computational Drug Signature 2,7-Bis(phenylacetamido)anthraquinone, curated by (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX007402 Genes associated with Computational Drug Signature Broussonin C Genes associated with Computational Drug Signature Broussonin C, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX010470 Genes associated with Computational Drug Signature CHEMBL428756 Genes associated with Computational Drug Signature CHEMBL428756, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX011367 Genes associated with Computational Drug Signature CHEMBL569315 Genes associated with Computational Drug Signature CHEMBL569315, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX011139 Genes associated with Computational Drug Signature CHEMBL521733 Genes associated with Computational Drug Signature CHEMBL521733, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX008677 Genes associated with Computational Drug Signature CHEMBL206902 Genes associated with Computational Drug Signature CHEMBL206902, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX008201 Genes associated with Computational Drug Signature CHEMBL144757 Genes associated with Computational Drug Signature CHEMBL144757, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX008864 Genes associated with Computational Drug Signature CHEMBL219096 Genes associated with Computational Drug Signature CHEMBL219096, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX008012 Genes associated with Computational Drug Signature CHEMBL121479 Genes associated with Computational Drug Signature CHEMBL121479, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009995 Genes associated with Computational Drug Signature CHEMBL383563 Genes associated with Computational Drug Signature CHEMBL383563, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009110 Genes associated with Computational Drug Signature CHEMBL244248 Genes associated with Computational Drug Signature CHEMBL244248, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX013345 Genes associated with Computational Drug Signature L 790070 Genes associated with Computational Drug Signature L-790070, curated by the Drug Signature Database (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX013041 Genes associated with Computational Drug Signature Hydrazinecarbothioamide, 2 cyclopentylidene Genes associated with Computational Drug Signature Hydrazinecarbothioamide, 2-cyclopentylidene-, cur (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009237 Genes associated with Computational Drug Signature CHEMBL259767 Genes associated with Computational Drug Signature CHEMBL259767, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009238 Genes associated with Computational Drug Signature CHEMBL259768 Genes associated with Computational Drug Signature CHEMBL259768, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX013266 Genes associated with Computational Drug Signature Kazinol F Genes associated with Computational Drug Signature Kazinol F, curated by the Drug Signature Database (more detail) 1 25990557.0 Homo sapiens

DSigDB TAX019339 GO:0017020 molecular function myosin phosphatase regulator activity Modulation of the activity of the enzyme myosin phosphatase. (more detail) 1 NA Homo sapiens

GOA MOX012161 Genes associated with Computational Drug Signature Daedalin A Genes associated with Computational Drug Signature Daedalin A, curated by the Drug Signature Databas (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX012271 Genes associated with Computational Drug Signature Diarylurea deriv. 15 Genes associated with Computational Drug Signature Diarylurea deriv. 15, curated by the Drug Signatu (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX014132 Genes associated with Computational Drug Signature NSC 745794 Genes associated with Computational Drug Signature NSC-745794, curated by the Drug Signature Databas (more detail) 1 25990557.0 Homo sapiens

DSigDB IEI010941 Protein protein interactors of human gene RAD51AP2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RAD51AP2 (SwissProt (more detail) 1 17535438 Homo sapiens

I2D IEI001608 Protein protein interactors of human gene C2orf74 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene C2orf74 (SwissProt I (more detail) 1 17535438 Homo sapiens

I2D NAX008071 ERCC3 (more detail) 1 NA Homo sapiens

Genome Data NAX001929 KLLN (more detail) 1 NA Homo sapiens

Genome Data NAX001431 CHEK2 (more detail) 1 NA Homo sapiens

Genome Data NAX011830 DDB2 (more detail) 1 NA Homo sapiens

Genome Data NAX014049 CTSC (more detail) 1 NA Homo sapiens

Genome Data NAX008961 AKT1 (more detail) 1 NA Homo sapiens

Genome Data NAX011028 PTEN (more detail) 1 NA Homo sapiens

Genome Data MEX002243 Genes associated with Kinase Inhibitor SB 682330 A Genes associated with Kinase Inhibitor SB-682330-A, curated by the Drug Signature Database (DSigDB). (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX003501 Genes associated with Computational Drug Signature Lomeguatrib Genes associated with Computational Drug Signature Lomeguatrib, curated by the Drug Signature Databa (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX003595 Genes associated with Computational Drug Signature 944396 07 0 Genes associated with Computational Drug Signature 944396-07-0, curated by the Drug Signature Databa (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX005998 Genes associated with Computational Drug Signature 4 (5 mercapto 1,3,4 oxadiazol 2 yl)phenol Genes associated with Computational Drug Signature 4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol, curate (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX006010 Genes associated with Computational Drug Signature 4 adamantyl resorcinol Genes associated with Computational Drug Signature 4-adamantyl resorcinol, curated by the Drug Signa (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX005595 Genes associated with Computational Drug Signature 2,7 Bis(benzoamido)anthraquinone Genes associated with Computational Drug Signature 2,7-Bis(benzoamido)anthraquinone, curated by the (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX005605 Genes associated with Computational Drug Signature 2,7 Bis[2 (diethylamino)acetamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[2-(diethylamino)acetamido]anthraquinone, (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX005617 Genes associated with Computational Drug Signature 2,7 Bis[3 (propylamino)propionamido]anthraquinone Genes associated with Computational Drug Signature 2,7-Bis[3-(propylamino)propionamido]anthraquinone (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX005619 Genes associated with Computational Drug Signature 2,7 Dinitroantraquinone Genes associated with Computational Drug Signature 2,7-Dinitroantraquinone, curated by the Drug Sign (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX006173 Genes associated with Computational Drug Signature 5 (4 Pyridyl) 1,3,4 oxadiazole 2 thiol Genes associated with Computational Drug Signature 5-(4-Pyridyl)-1,3,4-oxadiazole-2-thiol, curated b (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX006823 Genes associated with Computational Drug Signature AGN PC 0BMIYW Genes associated with Computational Drug Signature AGN-PC-0BMIYW, curated by the Drug Signature Data (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX008095 Genes associated with Computational Drug Signature CHEMBL1269349 Genes associated with Computational Drug Signature CHEMBL1269349, curated by the Drug Signature Data (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX008098 Genes associated with Computational Drug Signature CHEMBL1269399 Genes associated with Computational Drug Signature CHEMBL1269399, curated by the Drug Signature Data (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX010050 Genes associated with Computational Drug Signature CHEMBL388025 Genes associated with Computational Drug Signature CHEMBL388025, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009151 Genes associated with Computational Drug Signature CHEMBL248499 Genes associated with Computational Drug Signature CHEMBL248499, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009197 Genes associated with Computational Drug Signature CHEMBL256865 Genes associated with Computational Drug Signature CHEMBL256865, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX013444 Genes associated with Computational Drug Signature LGX 818 Genes associated with Computational Drug Signature LGX-818, curated by the Drug Signature Database ( (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009842 Genes associated with Computational Drug Signature CHEMBL373440 Genes associated with Computational Drug Signature CHEMBL373440, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009844 Genes associated with Computational Drug Signature CHEMBL373636 Genes associated with Computational Drug Signature CHEMBL373636, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX010168 Genes associated with Computational Drug Signature CHEMBL399354 Genes associated with Computational Drug Signature CHEMBL399354, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009243 Genes associated with Computational Drug Signature CHEMBL260172 Genes associated with Computational Drug Signature CHEMBL260172, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX010692 Genes associated with Computational Drug Signature CHEMBL450696 Genes associated with Computational Drug Signature CHEMBL450696, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009872 Genes associated with Computational Drug Signature CHEMBL375850 Genes associated with Computational Drug Signature CHEMBL375850, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009875 Genes associated with Computational Drug Signature CHEMBL375991 Genes associated with Computational Drug Signature CHEMBL375991, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009876 Genes associated with Computational Drug Signature CHEMBL375993 Genes associated with Computational Drug Signature CHEMBL375993, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX009272 Genes associated with Computational Drug Signature CHEMBL262340 Genes associated with Computational Drug Signature CHEMBL262340, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB TAX018397 GO:0014853 biological process regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of (more detail) 1 NA Homo sapiens

GOA TAX025044 GO:0045273 cellular component respiratory chain complex II A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase (more detail) 1 NA Homo sapiens

GOA TAX034408 GO:1990955 molecular function G rich single stranded DNA binding Interacting selectively and non-covalently with G-rich, single-stranded DNA. (more detail) 1 NA Homo sapiens

GOA TAX014659 GO:0003251 biological process positive regulation of cell proliferation involved in heart valve morphogenesis Any process that increases the rate, frequency or extent of cell proliferation that contributes to t (more detail) 1 NA Homo sapiens

GOA TAX033048 GO:1903620 biological process positive regulation of transdifferentiation Any process that activates or increases the frequency, rate or extent of transdifferentiation. (more detail) 1 NA Homo sapiens

GOA MOX012108 Genes associated with Computational Drug Signature Cyclo( D Tyr Arg Arg Nal Gly ) Genes associated with Computational Drug Signature Cyclo(-D-Tyr-Arg-Arg-Nal-Gly-), curated by the Dr (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX011551 Genes associated with Computational Drug Signature CHEMBL595241 Genes associated with Computational Drug Signature CHEMBL595241, curated by the Drug Signature Datab (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX012270 Genes associated with Computational Drug Signature Diarylurea deriv. 14a Genes associated with Computational Drug Signature Diarylurea deriv. 14a, curated by the Drug Signat (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX015777 Genes associated with Computational Drug Signature UNII ZN90E4027M Genes associated with Computational Drug Signature UNII-ZN90E4027M, curated by the Drug Signature Da (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX014135 Genes associated with Computational Drug Signature NSC 745797 Genes associated with Computational Drug Signature NSC-745797, curated by the Drug Signature Databas (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX014136 Genes associated with Computational Drug Signature NSC 745798 Genes associated with Computational Drug Signature NSC-745798, curated by the Drug Signature Databas (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX014140 Genes associated with Computational Drug Signature NSC 745886 Genes associated with Computational Drug Signature NSC-745886, curated by the Drug Signature Databas (more detail) 1 25990557.0 Homo sapiens

DSigDB MOX014142 Genes associated with Computational Drug Signature NSC 745888 Genes associated with Computational Drug Signature NSC-745888, curated by the Drug Signature Databas (more detail) 1 25990557.0 Homo sapiens

DSigDB IEI005448 Protein protein interactors of human gene GPR52 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GPR52 (SwissProt ID= (more detail) 1 17535438 Homo sapiens