Y-U
(more detail)
439 NA Homo sapiens
TAX030477
GO:0090304 biological process nucleic acid metabolic process Any cellular metabolic process involving nucleic acids. (more detail) 3889 NA Homo sapiens
TAX025594
GO:0046483 biological process heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular (more detail) 4579 NA Homo sapiens
TAX016555
GO:0006725 biological process cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized (more detail) 4620 NA Homo sapiens
TAX022578
GO:0034641 biological process cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, a (more detail) 4908 NA Homo sapiens
FEX012447
The normalized gene expressions no less than 30 in the tissue of skeletal muscle. Consensus transcript expression levels summarized per gene in 62 tissues based on transcriptomics da (more detail) 3023 25613900 Homo sapiens
TAX032108
GO:1901360 biological process organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound. (more detail) 4827 NA Homo sapiens
TAX001018
Genes annotated by the GO term GO:0043234. Any protein group composed of two or more subunits, which may or may not be identical. Protein complexes may have other associated non protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. (more detail) 791 NA Homo sapiens
TAX024488
GO:0043632 biological process modification dependent macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by cova (more detail) 464 NA Homo sapiens
TAX034189
GO:1990204 cellular component oxidoreductase complex Any protein complex that possesses oxidoreductase activity. (more detail) 101 NA Homo sapiens
TAX027094
GO:0051603 biological process proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pat (more detail) 526 NA Homo sapiens
TAX032693
GO:1902911 cellular component protein kinase complex A protein complex which is capable of protein kinase activity. (more detail) 99 NA Homo sapiens
TAX024652
GO:0044265 biological process cellular macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecul (more detail) 750 NA Homo sapiens
TAX029255
GO:0071013 cellular component catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in (more detail) 98 NA Homo sapiens
TAX016382
GO:0006511 biological process ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 448 NA Homo sapiens
TAX016256
GO:0006325 biological process chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of (more detail) 607 NA Homo sapiens
TAX033707
GO:1904949 cellular component ATPase complex A protein complex which is capable of ATPase activity. (more detail) 97 NA Homo sapiens
TAX019889
GO:0019941 biological process modification dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 454 NA Homo sapiens
TAX017473
GO:0009057 biological process macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of h (more detail) 907 NA Homo sapiens
TAX018849
GO:0016070 biological process RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main ty (more detail) 3393 NA Homo sapiens
TAX022627
GO:0034708 cellular component methyltransferase complex A protein complex that possesses methyltransferase activity. (more detail) 93 NA Homo sapiens
TAX019096
GO:0016570 biological process histone modification The covalent alteration of one or more amino acid residues within a histone protein. (more detail) 352 NA Homo sapiens
TAX019095
GO:0016569 biological process covalent chromatin modification The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups (more detail) 362 NA Homo sapiens
TAX020874
GO:0031248 cellular component protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule. (more detail) 89 NA Homo sapiens
TAX032529
GO:1902493 cellular component acetyltransferase complex A protein complex which is capable of acetyltransferase activity. (more detail) 89 NA Homo sapiens
FEX012538
The normalized gene expressions no less than 30 in the tissue of skeletal muscle from the Gene Tissue Expression project. Transcript expression levels summarized per gene in 36 tissues based on RNA-seq. The tab-separated f (more detail) 2206 25613900 Homo sapiens
TAX033898
GO:1905368 cellular component peptidase complex A protein complex which is capable of peptidase activity. (more detail) 88 NA Homo sapiens
TAX024743
GO:0044427 cellular component chromosomal part Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associ (more detail) 795 NA Homo sapiens
TAX032553
GO:1902554 cellular component serine/threonine protein kinase complex A protein complex which is capable of protein serine/threonine kinase activity. (more detail) 85 NA Homo sapiens
TAX017939
GO:0010498 biological process proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 279 NA Homo sapiens
TAX024191
GO:0043161 biological process proteasome mediated ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 257 NA Homo sapiens
TAX013265
GO:0000123 cellular component histone acetyltransferase complex A protein complex that possesses histone acetyltransferase activity. (more detail) 79 NA Homo sapiens
TAX015958
GO:0005829 cellular component cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate (more detail) 4846 NA Homo sapiens
TAX017797
GO:0009893 biological process positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 3295 NA Homo sapiens
TAX017992
GO:0010604 biological process positive regulation of macromolecule metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 3056 NA Homo sapiens
TAX000988
Genes annotated by the GO term GO:0044428. Any constituent part of the nucleus, a membrane bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. (more detail) 555 NA Homo sapiens
TAX024504
GO:0043687 biological process post translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been c (more detail) 362 NA Homo sapiens
WIG000698
Genes involved in Antigen processing: Ubiquitination & Proteasome degradation (more detail) 199 NA Homo sapiens
TAX019644
GO:0019219 biological process regulation of nucleobase containing compound metabolic process Any cellular process that modulates the frequency, rate or extent of the chemical reactions and path (more detail) 4087 NA Homo sapiens
TAX029699
GO:0071840 biological process cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of c (more detail) 4929 NA Homo sapiens
TAX021011
GO:0031463 cellular component Cul3 RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form (more detail) 71 NA Homo sapiens
TAX029028
GO:0070603 cellular component SWI/SNF superfamily type complex A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the cata (more detail) 71 NA Homo sapiens
TAX018835
GO:0016043 biological process cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellul (more detail) 4875 NA Homo sapiens
TAX020341
GO:0030163 biological process protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of th (more detail) 368 NA Homo sapiens
TAX017929
GO:0010468 biological process regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the (more detail) 4511 NA Homo sapiens
WIG000763
Genes involved in Class I MHC mediated antigen processing & presentation (more detail) 237 NA Homo sapiens
TAX022730
GO:0035097 cellular component histone methyltransferase complex A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. (more detail) 67 NA Homo sapiens
TAX020926
GO:0031326 biological process regulation of cellular biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resu (more detail) 4217 NA Homo sapiens
TAX017793
GO:0009889 biological process regulation of biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resu (more detail) 4286 NA Homo sapiens
TAX033899
GO:1905369 cellular component endopeptidase complex A protein complex which is capable of endopeptidase activity. (more detail) 64 NA Homo sapiens
TAX019492
GO:0018205 biological process peptidyl lysine modification The modification of peptidyl-lysine. (more detail) 256 NA Homo sapiens
TAX013446
GO:0000502 cellular component proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and s (more detail) 63 NA Homo sapiens
TAX015869
GO:0005681 cellular component spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleopro (more detail) 189 NA Homo sapiens
TAX013261
GO:0000118 cellular component histone deacetylase complex A protein complex that possesses histone deacetylase activity. (more detail) 61 NA Homo sapiens
WIG001825
DNA damage response and chromatin remodeling The packaging of eukaryotic chromosomal DNA into nucleosomes impedes the access of the DNA repair ma (more detail) 157 NA Homo sapiens
TAX016355
GO:0006473 biological process protein acetylation The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from ace (more detail) 129 NA Homo sapiens
TAX019099
GO:0016573 biological process histone acetylation The modification of a histone by the addition of an acetyl group. (more detail) 102 NA Homo sapiens
TAX020687
GO:0030880 cellular component RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one (more detail) 55 NA Homo sapiens
TAX016357
GO:0006475 biological process internal protein amino acid acetylation The addition of an acetyl group to a non-terminal amino acid in a protein. (more detail) 113 NA Homo sapiens
TAX019531
GO:0018394 biological process peptidyl lysine acetylation The acetylation of peptidyl-lysine. (more detail) 110 NA Homo sapiens
TAX024432
GO:0043543 biological process protein acylation The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to (more detail) 166 NA Homo sapiens
WIG001145
Genes involved in Regulation of mitotic cell cycle (more detail) 79 NA Homo sapiens
TAX019530
GO:0018393 biological process internal peptidyl lysine acetylation The addition of an acetyl group to a non-terminal lysine residue in a protein. (more detail) 107 NA Homo sapiens
TAX013410
GO:0000428 cellular component DNA directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity. (more detail) 53 NA Homo sapiens
TAX027542
GO:0055029 cellular component nuclear DNA directed RNA polymerase complex A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity. (more detail) 52 NA Homo sapiens
TAX031140
GO:0098803 cellular component respiratory chain complex Any protein complex that is part of a respiratory chain (more detail) 73 NA Homo sapiens
WIG001261
Genes involved in S Phase (more detail) 107 NA Homo sapiens
WIG000702
Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins (more detail) 67 NA Homo sapiens
TAX032874
GO:1903293 cellular component phosphatase complex A protein complex which is capable of phosphatase activity. (more detail) 50 NA Homo sapiens
TAX017177
GO:0008287 cellular component protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal (more detail) 50 NA Homo sapiens
TAX019572
GO:0019005 cellular component SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form (more detail) 50 NA Homo sapiens
WAG000275
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (more detail) 56 NA Homo sapiens
WAG001078
Autodegradation of Cdh1 by Cdh1:APC/C (more detail) 56 NA Homo sapiens
WIG000993
Genes involved in Mitotic G1 G1/S phases (more detail) 133 NA Homo sapiens
WAG000672
Cdc20:Phospho APC/C mediated degradation of Cyclin A (more detail) 59 NA Homo sapiens
WAG000874
APC/C:Cdc20 mediated degradation of Securin (more detail) 57 NA Homo sapiens
WIG000703
Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (more detail) 66 NA Homo sapiens
WIG000716
Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C (more detail) 58 NA Homo sapiens
WIG000780
Genes involved in Cyclin E associated events during G1/S transition (more detail) 63 NA Homo sapiens
WIG000854
Genes involved in G1/S Transition (more detail) 108 NA Homo sapiens
WIG001181
Genes involved in SCF(Skp2) mediated degradation of p27/p21 (more detail) 54 NA Homo sapiens
TAX025042
GO:0045271 cellular component respiratory chain complex I Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptid (more detail) 44 NA Homo sapiens
TAX015903
GO:0005747 cellular component mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial r (more detail) 44 NA Homo sapiens
TAX020432
GO:0030286 cellular component dynein complex Any of several large complexes that contain two or three dynein heavy chains and several light chain (more detail) 44 NA Homo sapiens
TAX020739
GO:0030964 cellular component NADH dehydrogenase complex An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the (more detail) 44 NA Homo sapiens
WIG001222
Genes involved in Signaling by Wnt (more detail) 63 NA Homo sapiens
WIG000744
Genes involved in Cell Cycle Checkpoints (more detail) 112 NA Homo sapiens
WIG001247
Genes involved in Synthesis of DNA (more detail) 91 NA Homo sapiens
WIG001146
Genes involved in Regulation of mRNA Stability by Proteins that Bind AU rich Elements (more detail) 82 NA Homo sapiens
IEI010651
Protein protein interactors of human gene PSMD14 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMD14 (SwissProt ID (more detail) 90 17535438 Homo sapiens
WAG000083
Electron Transport Chain (more detail) 61 NA Homo sapiens
TAX013362
GO:0000307 cellular component cyclin dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit (more detail) 40 NA Homo sapiens
TAX013279
GO:0000152 cellular component nuclear ubiquitin ligase complex A ubiquitin ligase complex found in the nucleus. (more detail) 40 NA Homo sapiens
TAX020228
GO:0022904 biological process respiratory electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors (more detail) 82 NA Homo sapiens
WAG001555
SCF(Skp2) mediated degradation of p27/p21 (more detail) 45 NA Homo sapiens
WIG001182
Genes involved in SCF beta TrCP mediated degradation of Emi1 (more detail) 50 NA Homo sapiens
WIG001055
Genes involved in p53 Dependent G1 DNA Damage Response (more detail) 53 NA Homo sapiens
WIG000793
Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) (more detail) 51 NA Homo sapiens
WAG000326
SCF beta TrCP mediated degradation of Emi1 (more detail) 44 NA Homo sapiens
WIG000667
Genes involved in Activation of NF kappaB in B Cells (more detail) 63 NA Homo sapiens
TAX032557
GO:1902562 cellular component H4 histone acetyltransferase complex A protein complex which is capable of H4 histone acetyltransferase activity. (more detail) 37 NA Homo sapiens
WAG000925
Ubiquitin dependent degradation of Cyclin D1 (more detail) 43 NA Homo sapiens
WAG000936
Vif mediated degradation of APOBEC3G (more detail) 43 NA Homo sapiens
WIG001314
Genes involved in Vif mediated degradation of APOBEC3G (more detail) 48 NA Homo sapiens
WAG001504
Degradation of beta catenin by the destruction complex (more detail) 46 NA Homo sapiens
TAX022372
GO:0034212 molecular function peptide N acetyltransferase activity Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reac (more detail) 66 NA Homo sapiens
WAG001375
Vpu mediated degradation of CD4 (more detail) 44 NA Homo sapiens
WIG000739
Genes involved in CDK mediated phosphorylation and removal of Cdc6 (more detail) 47 NA Homo sapiens
WAG001081
CDK mediated phosphorylation and removal of Cdc6 (more detail) 43 NA Homo sapiens
WIG001047
Genes involved in Orc1 removal from chromatin (more detail) 66 NA Homo sapiens
IEI000180
Protein protein interactors of human gene ACTL6A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ACTL6A (SwissProt ID (more detail) 88 17535438 Homo sapiens
WAG000708
Regulation of activated PAK 2p34 by proteasome mediated degradation (more detail) 41 NA Homo sapiens
TAX022292
GO:0034062 molecular function 5' 3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis (more detail) 41 NA Homo sapiens
WAG000099
Host Interactions of HIV factors (more detail) 41 NA Homo sapiens
TAX030991
GO:0097747 molecular function RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis (more detail) 41 NA Homo sapiens
IEI010650
Protein protein interactors of human gene PSMD13 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMD13 (SwissProt ID (more detail) 89 17535438 Homo sapiens
WAG001344
Regulation of activated PAK 2p34 by proteasome mediated degradation (more detail) 42 NA Homo sapiens
WAG001550
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (more detail) 42 NA Homo sapiens
WIG000775
Genes involved in Cross presentation of soluble exogenous antigens (endosomes) (more detail) 47 NA Homo sapiens
WIG000717
Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 (more detail) 47 NA Homo sapiens
IEI010658
Protein protein interactors of human gene PSMD8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMD8 (SwissProt ID= (more detail) 72 17535438 Homo sapiens
TAX014838
GO:0003899 molecular function DNA directed 5' 3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA (more detail) 38 NA Homo sapiens
TAX017082
GO:0008137 molecular function NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. (more detail) 38 NA Homo sapiens
TAX016146
GO:0006120 biological process mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, medi (more detail) 38 NA Homo sapiens
TAX026414
GO:0050136 molecular function NADH dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. (more detail) 38 NA Homo sapiens
WIG001147
Genes involved in Regulation of ornithine decarboxylase (ODC) (more detail) 48 NA Homo sapiens
WAG000730
Regulation of ornithine decarboxylase (ODC) (more detail) 43 NA Homo sapiens
WIG000600
Proteasome The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such (more detail) 46 NA Homo sapiens
WAG001005
Proteasome The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such (more detail) 41 NA Homo sapiens
WIG001056
Genes involved in p53 Independent G1/S DNA damage checkpoint (more detail) 49 NA Homo sapiens
IEI010635
Protein protein interactors of human gene PSMB6 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMB6 (SwissProt ID= (more detail) 58 17535438 Homo sapiens
TAX014873
GO:0003954 molecular function NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. (more detail) 39 NA Homo sapiens
TAX015961
GO:0005834 cellular component heterotrimeric G protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily (more detail) 33 NA Homo sapiens
TAX033895
GO:1905360 cellular component GTPase complex A protein complex which is capable of GTPase activity. (more detail) 33 NA Homo sapiens
WAG000922
Switching of origins to a post replicative state (more detail) 47 NA Homo sapiens
TAX017049
GO:0008080 molecular function N acetyltransferase activity Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. (more detail) 81 NA Homo sapiens
IEI010657
Protein protein interactors of human gene PSMD7 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMD7 (SwissProt ID= (more detail) 81 17535438 Homo sapiens
WIG001008
Genes involved in M/G1 Transition (more detail) 79 NA Homo sapiens
TAX030168
GO:0080008 cellular component Cul4 RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the (more detail) 32 NA Homo sapiens
FOX000850
Genes in the cancer module 91 (more detail) 36 NA Homo sapiens
TAX017885
GO:0010257 biological process NADH dehydrogenase complex assembly The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogena (more detail) 58 NA Homo sapiens
TAX021908
GO:0032981 biological process mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respi (more detail) 58 NA Homo sapiens
WIG001132
Genes involved in Regulation of Apoptosis (more detail) 57 NA Homo sapiens
WAG000696
Orc1 removal from chromatin (more detail) 55 NA Homo sapiens
WIG000740
Genes involved in CDT1 association with the CDC6:ORC:origin complex (more detail) 55 NA Homo sapiens
TAX015872
GO:0005684 cellular component U2 type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to exc (more detail) 70 NA Homo sapiens
MAX001963
Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 70 NA Homo sapiens
TAX015116
GO:0004402 molecular function histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. (more detail) 56 NA Homo sapiens
FOX000600
Genes in the cancer module 28 (more detail) 32 NA Homo sapiens
WAG000056
CDT1 association with the CDC6:ORC:origin complex (more detail) 50 NA Homo sapiens
TAX024547
GO:0043967 biological process histone H4 acetylation The modification of histone H4 by the addition of an acetyl group. (more detail) 50 NA Homo sapiens
WIG001492
Estrogen mediated S Phase Entry Estrogen-mediated S-Phase Entry (more detail) 48 NA Homo sapiens
TAX028564
GO:0061733 molecular function peptide lysine N acetyltransferase activity Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. (more detail) 58 NA Homo sapiens
TAX029397
GO:0071339 cellular component MLL1 complex A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransfe (more detail) 29 NA Homo sapiens
TAX029250
GO:0071007 cellular component U2 type catalytic step 2 spliceosome A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in wh (more detail) 29 NA Homo sapiens
TAX024813
GO:0044665 cellular component MLL1/2 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protei (more detail) 29 NA Homo sapiens
WIG000828
Genes involved in ER Phagosome pathway (more detail) 60 NA Homo sapiens
WIG000713
Genes involved in Assembly of the pre replicative complex (more detail) 64 NA Homo sapiens
WAG001143
Removal of licensing factors from origins (more detail) 57 NA Homo sapiens
TAX019150
GO:0016655 molecular function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or el (more detail) 51 NA Homo sapiens
TAX033891
GO:1905348 cellular component endonuclease complex A protein complex which is capable of endonuclease activity. (more detail) 28 NA Homo sapiens
TAX032554
GO:1902555 cellular component endoribonuclease complex A protein complex which is capable of endoribonuclease activity. (more detail) 28 NA Homo sapiens
TAX028943
GO:0070461 cellular component SAGA type complex A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the e (more detail) 28 NA Homo sapiens
WIG000615
RNA polymerase (more detail) 28 NA Homo sapiens
TAX024546
GO:0043966 biological process histone H3 acetylation The modification of histone H3 by the addition of an acetyl group. (more detail) 43 NA Homo sapiens
WIG001971
Eukaryotic Transcription Initiation Eukaryotic Transcription Initiation (more detail) 42 NA Homo sapiens
TAX033892
GO:1905354 cellular component exoribonuclease complex A protein complex which is capable of exoribonuclease activity. (more detail) 26 NA Homo sapiens
TAX013295
GO:0000178 cellular component exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuc (more detail) 26 NA Homo sapiens
FOX000834
Genes in the cancer module 77 (more detail) 28 NA Homo sapiens
WIG000409
Proteasome Complex Attachment of the ubiquitin peptide to proteins targets them for proteolytic degradation by a comple (more detail) 28 NA Homo sapiens
WAG001321
Elongation of Intron Containing Transcripts and co transcriptional mRNA splicing (more detail) 44 NA Homo sapiens
IEI010628
Protein protein interactors of human gene PSMA8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMA8 (SwissProt ID= (more detail) 33 17535438 Homo sapiens
WIG001039
Genes involved in Nucleotide Excision Repair (more detail) 49 NA Homo sapiens
FOX000716
Genes in the cancer module 42 (more detail) 25 NA Homo sapiens
TAX001049
Genes annotated by the GO term GO:0000151. A protein complex that includes a ubiquitin protein ligase (E3) and other proteins that may confer substrate specificity on the complex. (more detail) 25 NA Homo sapiens
WIG001615
Parkinson's Disease Pathway Parkinson's Disease Pathway (more detail) 44 NA Homo sapiens
TAX021034
GO:0031519 cellular component PcG protein complex A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polyc (more detail) 44 NA Homo sapiens
TAX021797
GO:0032806 cellular component carboxy terminal domain protein kinase complex A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain rep (more detail) 24 NA Homo sapiens
TAX030812
GO:0097346 cellular component INO80 type complex A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more tha (more detail) 24 NA Homo sapiens
WAG000333
mRNA Splicing Minor Pathway (more detail) 36 NA Homo sapiens
WIG001291
Genes involved in Transcription coupled NER (TC NER) (more detail) 44 NA Homo sapiens
WIG001003
Genes involved in mRNA Splicing Minor Pathway (more detail) 41 NA Homo sapiens
WIG001803
ABCG and ABCA Regulation of Sterol Metabolism ABCG and ABCA Regulation of Sterol Metabolism (more detail) 30 NA Homo sapiens
TAX031011
GO:0098533 cellular component ATPase dependent transmembrane transport complex A transmembrane protein complex that functions in ATPase dependent active transport across a membran (more detail) 22 NA Homo sapiens
WAG000846
proteasome complex Attachment of the ubiquitin peptide to proteins targets them for proteolytic degradation by a comple (more detail) 24 NA Homo sapiens
TAX015117
GO:0004407 molecular function histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This react (more detail) 44 NA Homo sapiens
TAX029253
GO:0071011 cellular component precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP t (more detail) 44 NA Homo sapiens
WIG001516
G2 M Phase Transition G2-M Phase Transition (more detail) 41 NA Homo sapiens
IEI010637
Protein protein interactors of human gene PSMB8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMB8 (SwissProt ID= (more detail) 42 17535438 Homo sapiens
WAG000706
RNA Polymerase II Transcription Initiation And Promoter Clearance (more detail) 39 NA Homo sapiens
WAG000279
Formation and Maturation of mRNA Transcript (more detail) 39 NA Homo sapiens
WAG000905
HIV 1 Transcription Pre Initiation (more detail) 39 NA Homo sapiens
WAG001124
RNA Polymerase II Transcription Initiation (more detail) 39 NA Homo sapiens
WAG000105
RNA Polymerase II Promoter Escape (more detail) 39 NA Homo sapiens
WAG001340
RNA Polymerase II Transcription Pre Initiation (more detail) 39 NA Homo sapiens
WAG000907
RNA Polymerase II Transcription (more detail) 39 NA Homo sapiens
WAG000124
Transcription of the HIV genome (more detail) 39 NA Homo sapiens
WAG001112
HIV 1 Transcription Initiation (more detail) 39 NA Homo sapiens
WAG001123
RNA Polymerase II HIV 1 Promoter Escape (more detail) 39 NA Homo sapiens
WAG000808
RNA polymerase (more detail) 21 NA Homo sapiens
TAX015868
GO:0005680 cellular component anaphase promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby tr (more detail) 21 NA Homo sapiens
TAX001016
Genes annotated by the GO term GO:0000502. A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. (more detail) 21 NA Homo sapiens
TAX013283
GO:0000159 cellular component protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulat (more detail) 21 NA Homo sapiens
WIG001172
Genes involved in RNA Polymerase II Transcription Pre Initiation And Promoter Opening (more detail) 40 NA Homo sapiens
WAG000321
Transcription coupled NER (TC NER) (more detail) 28 NA Homo sapiens
WAG000080
Dual incision reaction in TC NER (more detail) 28 NA Homo sapiens
WAG000071
Formation of transcription coupled NER (TC NER) repair complex (more detail) 28 NA Homo sapiens
WIG000848
Genes involved in Formation of transcription coupled NER (TC NER) repair complex (more detail) 29 NA Homo sapiens
TAX000910
Genes annotated by the GO term GO:0000118. Complex that possesses histone deacetylase activity. (more detail) 20 NA Homo sapiens
IEI013221
Protein protein interactors of human gene SUPT3H from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SUPT3H (SwissProt ID (more detail) 36 17535438 Homo sapiens
WAG000723
RNA Pol II CTD phosphorylation and interaction with CE (more detail) 25 NA Homo sapiens
WAG000313
RNA Pol II CTD phosphorylation and interaction with CE (more detail) 25 NA Homo sapiens
TAX020843
GO:0031146 biological process SCF dependent proteasomal ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 23 NA Homo sapiens
TAX024556
GO:0043984 biological process histone H4 K16 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 (more detail) 19 NA Homo sapiens
TAX015982
GO:0005868 cellular component cytoplasmic dynein complex Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microt (more detail) 19 NA Homo sapiens
TAX016026
GO:0005942 cellular component phosphatidylinositol 3 kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any p (more detail) 19 NA Homo sapiens
TAX022793
GO:0035267 cellular component NuA4 histone acetyltransferase complex A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and struct (more detail) 19 NA Homo sapiens
TAX024211
GO:0043189 cellular component H4/H2A histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histones H4 and H2A. (more detail) 19 NA Homo sapiens
WIG000845
Genes involved in Formation of RNA Pol II elongation complex (more detail) 36 NA Homo sapiens
TAX020842
GO:0031145 biological process anaphase promoting complex dependent catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 36 NA Homo sapiens
WAG001156
mRNA Capping (more detail) 27 NA Homo sapiens
FOX000551
Genes in the cancer module 22 (more detail) 34 NA Homo sapiens
TAX015857
GO:0005665 cellular component RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a m (more detail) 18 NA Homo sapiens
WAG000527
Tat mediated elongation of the HIV 1 transcript (more detail) 35 NA Homo sapiens
WAG000718
Processing of Capped Intron Containing Pre mRNA (more detail) 35 NA Homo sapiens
WIG001550
Huntingtin Comparative Pathway Huntingtin Comparative Pathway (more detail) 26 NA Homo sapiens
WIG000998
Genes involved in mRNA Capping (more detail) 29 NA Homo sapiens
WIG000846
Genes involved in Formation of the HIV 1 Early Elongation Complex (more detail) 29 NA Homo sapiens
TAX025119
GO:0045503 molecular function dynein light chain binding Interacting selectively and non-covalently with a light chain of the dynein complex. (more detail) 21 NA Homo sapiens
WAG001346
Regulation of APC/C activators between G1/S and early anaphase (more detail) 19 NA Homo sapiens
TAX015963
GO:0005839 cellular component proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. (more detail) 19 NA Homo sapiens
TAX020196
GO:0022624 cellular component proteasome accessory complex A protein complex, that caps one or both ends of the proteasome core complex and regulates entry int (more detail) 17 NA Homo sapiens
TAX015858
GO:0005666 cellular component RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a (more detail) 17 NA Homo sapiens
TAX019107
GO:0016581 cellular component NuRD complex An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activi (more detail) 17 NA Homo sapiens
TAX030562
GO:0090545 cellular component CHD type complex A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) famil (more detail) 17 NA Homo sapiens
WAG001111
HIV 1 Transcription Elongation (more detail) 31 NA Homo sapiens
WAG001499
Formation of the Early Elongation Complex (more detail) 31 NA Homo sapiens
WAG001302
Formation of the HIV 1 Early Elongation Complex (more detail) 31 NA Homo sapiens
TAX025121
GO:0045505 molecular function dynein intermediate chain binding Interacting selectively and non-covalently with an intermediate chain of the dynein complex. (more detail) 28 NA Homo sapiens
TAX016286
GO:0006370 biological process 7 methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. (more detail) 32 NA Homo sapiens
TAX019083
GO:0016538 molecular function cyclin dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein (more detail) 29 NA Homo sapiens
WIG001468
DNA Methylation and Transcriptional Repression DNA Methylation and Transcriptional Repression (more detail) 23 NA Homo sapiens
TAX029123
GO:0070822 cellular component Sin3 type complex Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core (more detail) 16 NA Homo sapiens
IEI006404
Protein protein interactors of human gene INO80D from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene INO80D (SwissProt ID (more detail) 16 17535438 Homo sapiens
TAX020758
GO:0031011 cellular component Ino80 complex A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activi (more detail) 16 NA Homo sapiens
TAX015976
GO:0005858 cellular component axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjace (more detail) 16 NA Homo sapiens
TAX022034
GO:0033202 cellular component DNA helicase complex A protein complex that possesses DNA helicase activity. (more detail) 16 NA Homo sapiens
TAX013293
GO:0000176 cellular component nuclear exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuc (more detail) 16 NA Homo sapiens
TAX023906
GO:0042575 cellular component DNA polymerase complex A protein complex that possesses DNA polymerase activity and is involved in template directed synthe (more detail) 16 NA Homo sapiens
TAX019879
GO:0019908 cellular component nuclear cyclin dependent protein kinase holoenzyme complex Cyclin-dependent protein kinase (CDK) complex found in the nucleus. (more detail) 16 NA Homo sapiens
TAX001361
Genes annotated by the GO term GO:0034062. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. (more detail) 16 NA Homo sapiens
TAX022731
GO:0035098 cellular component ESC/E(Z) complex A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Dr (more detail) 16 NA Homo sapiens
WAG000074
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (more detail) 16 NA Homo sapiens
TAX015038
GO:0004298 molecular function threonine type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which (more detail) 21 NA Homo sapiens
TAX028680
GO:0070003 molecular function threonine type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydr (more detail) 21 NA Homo sapiens
WIG000898
Genes involved in G protein activation (more detail) 27 NA Homo sapiens
TAX015870
GO:0005682 cellular component U5 snRNP A ribonucleoprotein complex that contains small nuclear RNA U5. (more detail) 22 NA Homo sapiens
WAG001293
APC/C:Cdc20 mediated degradation of Cyclin B (more detail) 17 NA Homo sapiens
WIG001165
Genes involved in RNA Polymerase III Chain Elongation (more detail) 17 NA Homo sapiens
TAX013599
GO:0001056 molecular function RNA polymerase III activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA (more detail) 15 NA Homo sapiens
TAX015862
GO:0005671 cellular component Ada2/Gcn5/Ada3 transcription activator complex A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of tra (more detail) 15 NA Homo sapiens
TAX030557
GO:0090533 cellular component cation transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in (more detail) 15 NA Homo sapiens
TAX024554
GO:0043982 biological process histone H4 K8 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 (more detail) 15 NA Homo sapiens
TAX024553
GO:0043981 biological process histone H4 K5 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 (more detail) 15 NA Homo sapiens
TAX019069
GO:0016514 cellular component SWI/SNF complex A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconser (more detail) 15 NA Homo sapiens
TAX013266
GO:0000124 cellular component SAGA complex A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog the (more detail) 15 NA Homo sapiens
WAG000667
APC/C mediated degradation of cell cycle proteins (more detail) 15 NA Homo sapiens
PEX001185
Proteasome: Proteasome subunit The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essenti (more detail) 15 NA Homo sapiens
TAX021119
GO:0031683 molecular function G protein beta/gamma subunit complex binding Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. (more detail) 20 NA Homo sapiens
TAX015874
GO:0005686 cellular component U2 snRNP A ribonucleoprotein complex that contains small nuclear RNA U2. (more detail) 20 NA Homo sapiens
TAX000966
Genes annotated by the GO term GO:0005746. The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I, III and IV can transport protons if embedded in an oriented membrane, such as an intact mitochondrial inner membrane. (more detail) 26 NA Homo sapiens
WIG001275
Genes involved in Thromboxane signalling through TP receptor (more detail) 23 NA Homo sapiens
WAG000906
Inactivation of APC/C via direct inhibition of the APC/C complex (more detail) 18 NA Homo sapiens
TAX017351
GO:0008569 molecular function ATP dependent microtubule motor activity, minus end directed Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP. (more detail) 18 NA Homo sapiens
WIG001074
Genes involved in Phosphorylation of the APC/C (more detail) 18 NA Homo sapiens
WIG000989
Genes involved in MicroRNA (miRNA) Biogenesis (more detail) 18 NA Homo sapiens
MAX002049
Composition of the 2 MDa human TFTC complex containing KAT2A [GeneID=2648] . Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific transcriptional (more detail) 18 NA Homo sapiens
MOX003517
Genes associated with Computational Drug Signature Carfilzomib Genes associated with Computational Drug Signature Carfilzomib, curated by the Drug Signature Databa (more detail) 27 25990557 Homo sapiens
IEI015150
Protein protein interactors of human gene YEATS2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene YEATS2 (SwissProt ID (more detail) 24 17535438 Homo sapiens
WIG000701
Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B (more detail) 21 NA Homo sapiens
WAG000509
Phosphorylation of the APC/C (more detail) 16 NA Homo sapiens
TAX024548
GO:0043968 biological process histone H2A acetylation The modification of histone H2A by the addition of an acetyl group. (more detail) 16 NA Homo sapiens
TAX029542
GO:0071565 cellular component nBAF complex A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and protei (more detail) 14 NA Homo sapiens
TAX013285
GO:0000164 cellular component protein phosphatase type 1 complex A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosp (more detail) 14 NA Homo sapiens
TAX022068
GO:0033276 cellular component transcription factor TFTC complex A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, bu (more detail) 14 NA Homo sapiens
WAG001326
MicroRNA biogenesis (more detail) 14 NA Homo sapiens
WAG000466
APC/C:Cdc20 mediated degradation of mitotic proteins (more detail) 19 NA Homo sapiens
WIG000929
Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (more detail) 19 NA Homo sapiens
WIG001169
Genes involved in RNA Polymerase III Transcription Termination (more detail) 19 NA Homo sapiens
TAX001032
Genes annotated by the GO term GO:0030532. A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs. (more detail) 22 NA Homo sapiens
WIG000768
Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (more detail) 17 NA Homo sapiens
WAG000455
APC Cdc20 mediated degradation of Nek2A (more detail) 20 NA Homo sapiens
FOX000769
Genes in the cancer module 50 (more detail) 13 NA Homo sapiens
TAX026083
GO:0048188 cellular component Set1C/COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex c (more detail) 13 NA Homo sapiens
TAX019106
GO:0016580 cellular component Sin3 complex A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor (more detail) 13 NA Homo sapiens
TAX013294
GO:0000177 cellular component cytoplasmic exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity pr (more detail) 13 NA Homo sapiens
FOX000577
Genes in the cancer module 25 (more detail) 13 NA Homo sapiens
TAX000537
Genes annotated by the GO term GO:0006497. The covalent or non covalent attachment of lipid moieties to an amino acid in a protein. (more detail) 24 NA Homo sapiens
WIG000683
Genes involved in ADP signalling through P2Y purinoceptor 12 (more detail) 21 NA Homo sapiens
WIG001153
Genes involved in Regulatory RNA pathways (more detail) 21 NA Homo sapiens
WAG001130
RNA Polymerase I Chain Elongation (more detail) 19 NA Homo sapiens
WAG000724
RNA Polymerase I Transcription (more detail) 19 NA Homo sapiens
MAX002048
Composition of the 2 MDa human STAGA complex containing KAT2A [GeneID=2648] . Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific transcriptional (more detail) 14 NA Homo sapiens
TAX013280
GO:0000153 cellular component cytoplasmic ubiquitin ligase complex A ubiquitin ligase complex found in the cytoplasm. (more detail) 12 NA Homo sapiens
TAX021073
GO:0031597 cellular component cytosolic proteasome complex A proteasome complex found in the cytosol of a cell. (more detail) 12 NA Homo sapiens
TAX022733
GO:0035102 cellular component PRC1 complex A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-11 (more detail) 12 NA Homo sapiens
TAX015905
GO:0005750 cellular component mitochondrial respiratory chain complex III A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial r (more detail) 12 NA Homo sapiens
TAX029541
GO:0071564 cellular component npBAF complex A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin (more detail) 12 NA Homo sapiens
TAX022628
GO:0034709 cellular component methylosome A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifi (more detail) 12 NA Homo sapiens
TAX015866
GO:0005675 cellular component holo TFIIH complex A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the lar (more detail) 12 NA Homo sapiens
TAX020718
GO:0030914 cellular component STAGA complex A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation (more detail) 12 NA Homo sapiens
TAX020617
GO:0030677 cellular component ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-t (more detail) 12 NA Homo sapiens
TAX015998
GO:0005890 cellular component sodium:potassium exchanging ATPase complex Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits (more detail) 12 NA Homo sapiens
TAX017151
GO:0008250 cellular component oligosaccharyltransferase complex A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers li (more detail) 12 NA Homo sapiens
TAX025045
GO:0045275 cellular component respiratory chain complex III A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two proto (more detail) 12 NA Homo sapiens
TAX021012
GO:0031464 cellular component Cul4A RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form (more detail) 12 NA Homo sapiens
WAG000115
RNA Polymerase I Promoter Clearance (more detail) 20 NA Homo sapiens
WAG000314
RNA Polymerase I Transcription Initiation (more detail) 20 NA Homo sapiens
WIG001177
Genes involved in RNA Polymerase I Transcription Termination (more detail) 20 NA Homo sapiens
WAG001545
RNA Polymerase I Promoter Escape (more detail) 20 NA Homo sapiens
WAG000705
RNA Polymerase I Transcription Termination (more detail) 20 NA Homo sapiens
TAX001023
Genes annotated by the GO term GO:0045271. Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. (more detail) 17 NA Homo sapiens
TAX000967
Genes annotated by the GO term GO:0005747. A part of the respiratory chain located in the mitochondrion. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron sulfur clusters containing non heme iron. The iron undergoes oxidation reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. (more detail) 17 NA Homo sapiens
TAX017218
GO:0008353 molecular function RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA (more detail) 17 NA Homo sapiens
TAX024026
GO:0042800 molecular function histone methyltransferase activity (H3 K4 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L (more detail) 17 NA Homo sapiens
TAX000973
Genes annotated by the GO term GO:0030964. An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyses the transfer of a pair of electrons from NADH to a quinone. (more detail) 17 NA Homo sapiens
IEI006403
Protein protein interactors of human gene INO80C from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene INO80C (SwissProt ID (more detail) 21 17535438 Homo sapiens
TAX015214
GO:0004549 molecular function tRNA specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. (more detail) 15 NA Homo sapiens
IEI006888
Protein protein interactors of human gene KLF1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene KLF1 (SwissProt ID=Q (more detail) 18 17535438 Homo sapiens
TAX030929
GO:0097602 molecular function cullin family protein binding Interacting selectively and non-covalently with any member of the cullin family, hydrophobic protein (more detail) 18 NA Homo sapiens
FEX001628
Leukemia Ueno09 26genes Table 2. Changes in cell cycle-related genes after PU.1 induction (more detail) 18 19749795 Homo sapiens
TAX025030
GO:0045239 cellular component tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. (more detail) 13 NA Homo sapiens
WIG001109
Genes involved in Prostacyclin signalling through prostacyclin receptor (more detail) 19 NA Homo sapiens
IEI000196
Protein protein interactors of human gene ACTR5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ACTR5 (SwissProt ID= (more detail) 19 17535438 Homo sapiens
IEI007759
Protein protein interactors of human gene MBD3L2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MBD3L2 (SwissProt ID (more detail) 11 17535438 Homo sapiens
IEI000557
Protein protein interactors of human gene ANAPC15 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ANAPC15 (SwissProt I (more detail) 11 17535438 Homo sapiens
TAX025031
GO:0045240 cellular component dihydrolipoyl dehydrogenase complex A protein complex that possesses alpha-ketoglutarate dehydrogenase activity. (more detail) 11 NA Homo sapiens
TAX020794
GO:0031078 molecular function histone deacetylase activity (H3 K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine ( (more detail) 11 NA Homo sapiens
TAX017234
GO:0008385 cellular component IkappaB kinase complex A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is (more detail) 11 NA Homo sapiens
TAX014102
GO:0002178 cellular component palmitoyltransferase complex A protein complex with palmitoyltransferase activity. (more detail) 11 NA Homo sapiens
TAX019112
GO:0016591 cellular component RNA polymerase II, holoenzyme A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as (more detail) 11 NA Homo sapiens
TAX013598
GO:0001055 molecular function RNA polymerase II activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA (more detail) 11 NA Homo sapiens
TAX021010
GO:0031462 cellular component Cul2 RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form (more detail) 11 NA Homo sapiens
TAX021301
GO:0032041 molecular function NAD dependent histone deacetylase activity (H3 K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine ( (more detail) 11 NA Homo sapiens
TAX015893
GO:0005736 cellular component RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a mu (more detail) 11 NA Homo sapiens
IEI000198
Protein protein interactors of human gene ACTR8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ACTR8 (SwissProt ID= (more detail) 16 17535438 Homo sapiens
WIG001315
Genes involved in Viral Messenger RNA Synthesis (more detail) 14 NA Homo sapiens
TAX000881
Genes annotated by the GO term GO:0000428. A protein complex that possesses DNA directed RNA polymerase activity. (more detail) 17 NA Homo sapiens
TAX001027
Genes annotated by the GO term GO:0030880. Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. (more detail) 17 NA Homo sapiens
TAX000981
Genes annotated by the GO term GO:0055029. A protein complex, located in the nucleus, that possesses DNA directed RNA polymerase activity. (more detail) 17 NA Homo sapiens
WAG000909
RNA Polymerase III Transcription Termination (more detail) 12 NA Homo sapiens
TAX017338
GO:0008540 cellular component proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome co (more detail) 12 NA Homo sapiens
WAG001527
RNA Polymerase III Chain Elongation (more detail) 12 NA Homo sapiens
WAG000308
RNA Polymerase III Transcription (more detail) 12 NA Homo sapiens
IEI000558
Protein protein interactors of human gene ANAPC16 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ANAPC16 (SwissProt I (more detail) 18 17535438 Homo sapiens
TAX016356
GO:0006474 biological process N terminal protein amino acid acetylation The acetylation of the N-terminal amino acid of proteins. (more detail) 15 NA Homo sapiens
IEI007758
Protein protein interactors of human gene MBD3L1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MBD3L1 (SwissProt ID (more detail) 10 17535438 Homo sapiens
TAX020976
GO:0031414 cellular component N terminal protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acce (more detail) 10 NA Homo sapiens
TAX021065
GO:0031588 cellular component nucleotide activated protein kinase complex A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be (more detail) 10 NA Homo sapiens
TAX015203
GO:0004526 molecular function ribonuclease P activity Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. (more detail) 10 NA Homo sapiens
TAX020757
GO:0031010 cellular component ISWI type complex Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. I (more detail) 10 NA Homo sapiens
PEX001303
Cyclin N: Cyclin, N terminal domain Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is r (more detail) 10 NA Homo sapiens
TAX020619
GO:0030681 cellular component multimeric ribonuclease P complex A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules (more detail) 10 NA Homo sapiens
TAX000998
Genes annotated by the GO term GO:0008250. A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits, at least in yeast. (more detail) 10 NA Homo sapiens
TAX024110
GO:0043020 cellular component NADPH oxidase complex A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) cha (more detail) 10 NA Homo sapiens
TAX000992
Genes annotated by the GO term GO:0000152. A ubiquitin ligase complex found in the nucleus. (more detail) 10 NA Homo sapiens
WAG000028
the prc2 complex sets long term gene silencing through modification of histone tails Packaging of D into chromatin allows the cell to store its genetic information efficiently and has a (more detail) 10 NA Homo sapiens
TAX013512
GO:0000812 cellular component Swr1 complex A multisubunit protein complex that is involved in chromatin remodeling. It is required for the inco (more detail) 10 NA Homo sapiens
TAX019401
GO:0017136 molecular function NAD dependent histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This react (more detail) 16 NA Homo sapiens
FOX000689
Genes in the cancer module 388 (more detail) 16 NA Homo sapiens
TAX017936
GO:0010485 molecular function H4 histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. (more detail) 16 NA Homo sapiens
IEI000556
Protein protein interactors of human gene ANAPC13 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ANAPC13 (SwissProt I (more detail) 13 17535438 Homo sapiens
TAX031318
GO:0099116 biological process tRNA 5' end processing The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA. (more detail) 13 NA Homo sapiens
TAX013567
GO:0000974 cellular component Prp19 complex A protein complex consisting of Prp19 and associated proteins that is involved in the transition fro (more detail) 13 NA Homo sapiens
WIG000999
Genes involved in mRNA Decay by 3' to 5' Exoribonuclease (more detail) 11 NA Homo sapiens
TAX019803
GO:0019774 cellular component proteasome core complex, beta subunit complex The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. (more detail) 11 NA Homo sapiens
TAX017347
GO:0008556 molecular function potassium transporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 11 NA Homo sapiens
TAX015875
GO:0005687 cellular component U4 snRNP A ribonucleoprotein complex that contains small nuclear RNA U4. (more detail) 11 NA Homo sapiens
TAX016148
GO:0006122 biological process mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylatio (more detail) 11 NA Homo sapiens
TAX029017
GO:0070578 cellular component RISC loading complex A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RIS (more detail) 9 NA Homo sapiens
TAX024562
GO:0043995 molecular function histone acetyltransferase activity (H4 K5 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acety (more detail) 9 NA Homo sapiens
WAG000332
mRNA Processing (more detail) 9 NA Homo sapiens
MAX002047
Composition of the 2 MDa human PCAF complex. Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific transcriptional (more detail) 9 NA Homo sapiens
TAX024563
GO:0043996 molecular function histone acetyltransferase activity (H4 K8 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acety (more detail) 9 NA Homo sapiens
TAX020953
GO:0031371 cellular component ubiquitin conjugating enzyme complex Any complex that possesses ubiquitin conjugating enzyme activity. (more detail) 9 NA Homo sapiens
TAX025842
GO:0046972 molecular function histone acetyltransferase activity (H4 K16 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acet (more detail) 9 NA Homo sapiens
TAX015240
GO:0004579 molecular function dolichyl diphosphooligosaccharide protein glycotransferase activity Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl dipho (more detail) 9 NA Homo sapiens
MEX001071
Genes associated with Approved Drug belinostat Genes associated with Approved Drug belinostat, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
TAX023292
GO:0036157 cellular component outer dynein arm Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Out (more detail) 9 NA Homo sapiens
TAX024814
GO:0044666 cellular component MLL3/4 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protei (more detail) 9 NA Homo sapiens
TAX001019
Genes annotated by the GO term GO:0008287. A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. (more detail) 9 NA Homo sapiens
TAX013597
GO:0001054 molecular function RNA polymerase I activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA (more detail) 9 NA Homo sapiens
TAX028832
GO:0070262 biological process peptidyl serine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine. (more detail) 12 NA Homo sapiens
TAX025120
GO:0045504 molecular function dynein heavy chain binding Interacting selectively and non-covalently with a heavy chain of the dynein complex. (more detail) 10 NA Homo sapiens
TAX001324
Genes annotated by the GO term GO:0033558. Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. (more detail) 10 NA Homo sapiens
TAX015237
GO:0004576 molecular function oligosaccharyl transferase activity Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbo (more detail) 10 NA Homo sapiens
TAX022481
GO:0034427 biological process nuclear transcribed mRNA catabolic process, exonucleolytic, 3' 5' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occu (more detail) 10 NA Homo sapiens
TAX019522
GO:0018342 biological process protein prenylation The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups (more detail) 10 NA Homo sapiens
TAX015746
GO:0005391 molecular function sodium:potassium exchanging ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 10 NA Homo sapiens
TAX030815
GO:0097354 biological process prenylation The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups (more detail) 10 NA Homo sapiens
TAX029259
GO:0071025 biological process RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs. (more detail) 13 NA Homo sapiens
IEI004199
Protein protein interactors of human gene EPC2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EPC2 (SwissProt ID=Q (more detail) 13 17535438 Homo sapiens
TAX030169
GO:0080009 biological process mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule. (more detail) 13 NA Homo sapiens
TAX017020
GO:0008024 cellular component cyclin/CDK positive transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productiv (more detail) 8 NA Homo sapiens
TAX025051
GO:0045293 cellular component mRNA editing complex A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleo (more detail) 8 NA Homo sapiens
TAX020858
GO:0031211 cellular component endoplasmic reticulum palmitoyltransferase complex A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C (more detail) 8 NA Homo sapiens
TAX017198
GO:0008318 molecular function protein prenyltransferase activity Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group (more detail) 8 NA Homo sapiens
WIG001541
Hepatic ABC Transporters Hepatic ABC Transporters (more detail) 8 NA Homo sapiens
TAX023370
GO:0036396 cellular component RNA N6 methyladenosine methyltransferase complex A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to (more detail) 8 NA Homo sapiens
TAX025035
GO:0045254 cellular component pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises sub (more detail) 8 NA Homo sapiens
TAX019134
GO:0016624 molecular function oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts (more detail) 8 NA Homo sapiens
TAX021072
GO:0031595 cellular component nuclear proteasome complex A proteasome found in the nucleus of a cell. (more detail) 8 NA Homo sapiens
TAX019356
GO:0017059 cellular component serine C palmitoyltransferase complex An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphin (more detail) 8 NA Homo sapiens
TAX019802
GO:0019773 cellular component proteasome core complex, alpha subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. (more detail) 8 NA Homo sapiens
TAX013447
GO:0000506 cellular component glycosylphosphatidylinositol N acetylglucosaminyltransferase (GPI GnT) complex An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidyli (more detail) 8 NA Homo sapiens
TAX022518
GO:0034475 biological process U4 snRNA 3' end processing Any process involved in forming the mature 3' end of a U4 snRNA molecule. (more detail) 8 NA Homo sapiens
TAX034129
GO:1905961 cellular component protein cysteine S palmitoyltransferase complex A protein complex which is capable of protein-cysteine S-palmitoyltransferase activity. (more detail) 8 NA Homo sapiens
TAX032129
GO:1901409 biological process positive regulation of phosphorylation of RNA polymerase II C terminal domain Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA poly (more detail) 8 NA Homo sapiens
TAX029254
GO:0071012 cellular component catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic sp (more detail) 8 NA Homo sapiens
TAX029261
GO:0071027 biological process nuclear RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs within the nuc (more detail) 11 NA Homo sapiens
TAX001135
Genes annotated by the GO term GO:0019213. Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. (more detail) 11 NA Homo sapiens
WAG000850
mechanisms of transcriptional repression by dna methylation Tumorigenesis is known to be a multistep process in which defects in various cancer genes accumulate (more detail) 11 NA Homo sapiens
TAX015253
GO:0004596 molecular function peptide alpha N acetyltransferase activity Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the (more detail) 11 NA Homo sapiens
WAG000888
Lagging Strand Synthesis (more detail) 9 NA Homo sapiens
WAG000285
DNA strand elongation (more detail) 9 NA Homo sapiens
TAX013771
GO:0001682 biological process tRNA 5' leader removal Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. (more detail) 9 NA Homo sapiens
TAX015962
GO:0005838 cellular component proteasome regulatory particle A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex rec (more detail) 9 NA Homo sapiens
WAG000293
Leading Strand Synthesis (more detail) 9 NA Homo sapiens
WAG001548
Telomere C strand (Lagging Strand) Synthesis (more detail) 9 NA Homo sapiens
TAX023364
GO:0036376 biological process sodium ion export across plasma membrane The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the (more detail) 9 NA Homo sapiens
WAG001128
Processive synthesis on the lagging strand (more detail) 9 NA Homo sapiens
TAX029188
GO:0070922 biological process small RNA loading onto RISC The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (more detail) 9 NA Homo sapiens
IEI003378
Protein protein interactors of human gene DCUN1D3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DCUN1D3 (SwissProt I (more detail) 12 17535438 Homo sapiens
WIG000928
Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 (more detail) 12 NA Homo sapiens
MAX003000
Subunits of the anaphase promoting complex (APC). Genomic instability can be found in most cancer cells. Cell proliferation is under tight control to (more detail) 12 NA Homo sapiens
WIG001448
Chromatin Remodeling Chromatin Remodeling (more detail) 12 NA Homo sapiens
TAX024212
GO:0043190 cellular component ATP binding cassette (ABC) transporter complex A complex for the transport of metabolites into and out of the cell, typically comprised of four dom (more detail) 7 NA Homo sapiens
TAX029976
GO:0072357 cellular component PTW/PP1 phosphatase complex A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or (more detail) 7 NA Homo sapiens
TAX029109
GO:0070776 cellular component MOZ/MORF histone acetyltransferase complex A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities (more detail) 7 NA Homo sapiens
TAX029108
GO:0070775 cellular component H3 histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histone H3. (more detail) 7 NA Homo sapiens
TAX034216
GO:1990316 cellular component Atg1/ULK1 kinase complex A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along w (more detail) 7 NA Homo sapiens
PEX001284
Hist deacetyl: Histone deacetylase domain Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is cau (more detail) 7 NA Homo sapiens
TAX022691
GO:0035005 molecular function 1 phosphatidylinositol 4 phosphate 3 kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo- (more detail) 7 NA Homo sapiens
TAX022701
GO:0035032 cellular component phosphatidylinositol 3 kinase complex, class III A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinas (more detail) 7 NA Homo sapiens
TAX019878
GO:0019907 cellular component cyclin dependent protein kinase activating kinase holoenzyme complex A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases b (more detail) 7 NA Homo sapiens
TAX015850
GO:0005655 cellular component nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' en (more detail) 7 NA Homo sapiens
PEX002507
RNase PH: 3' exoribonuclease family, domain 1 This family includes 3-5 exoribonucleases. Ribonuclease PH contains a single copy of this domain, a (more detail) 7 NA Homo sapiens
TAX024489
GO:0043633 biological process polyadenylation dependent RNA catabolic process The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by init (more detail) 7 NA Homo sapiens
TAX025034
GO:0045252 cellular component oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; (more detail) 7 NA Homo sapiens
TAX015316
GO:0004679 molecular function AMP activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the pres (more detail) 7 NA Homo sapiens
PEX000832
Proteasome A N: Proteasome subunit A N terminal signature This domain is conserved in the A subunits of the proteasome complex proteins. (more detail) 7 NA Homo sapiens
TAX020719
GO:0030915 cellular component Smc5 Smc6 complex A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereo (more detail) 7 NA Homo sapiens
TAX024555
GO:0043983 biological process histone H4 K12 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 (more detail) 7 NA Homo sapiens
TAX031574
GO:0106068 cellular component SUMO ligase complex A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase an (more detail) 7 NA Homo sapiens
PEX001617
Cullin: Cullin family (more detail) 7 NA Homo sapiens
TAX017339
GO:0008541 cellular component proteasome regulatory particle, lid subcomplex The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added o (more detail) 7 NA Homo sapiens
TAX021014
GO:0031466 cellular component Cul5 RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form (more detail) 7 NA Homo sapiens
IEI011560
Protein protein interactors of human gene RPP25 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RPP25 (SwissProt ID= (more detail) 10 17535438 Homo sapiens
IEI008542
Protein protein interactors of human gene NACC2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NACC2 (SwissProt ID= (more detail) 10 17535438 Homo sapiens
TAX032128
GO:1901407 biological process regulation of phosphorylation of RNA polymerase II C terminal domain Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-t (more detail) 10 NA Homo sapiens
IEI014826
Protein protein interactors of human gene UVSSA from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UVSSA (SwissProt ID= (more detail) 10 17535438 Homo sapiens
MEX000534
Genes associated with Approved Drug deslanoside Genes associated with Approved Drug deslanoside, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
IEI011564
Protein protein interactors of human gene RPP40 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RPP40 (SwissProt ID= (more detail) 11 17535438 Homo sapiens
TAX020834
GO:0031125 biological process rRNA 3' end processing Any process involved in forming the mature 3' end of an rRNA molecule. (more detail) 11 NA Homo sapiens
TAX000560
Genes annotated by the GO term GO:0000209. Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain. (more detail) 11 NA Homo sapiens
IEI005586
Protein protein interactors of human gene GTF2H5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GTF2H5 (SwissProt ID (more detail) 8 17535438 Homo sapiens
TAX031734
GO:0150005 cellular component enzyme activator complex A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catal (more detail) 8 NA Homo sapiens
TAX013418
GO:0000439 cellular component core TFIIH complex The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or (more detail) 8 NA Homo sapiens
TAX030640
GO:0097027 molecular function ubiquitin protein transferase activator activity Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent att (more detail) 8 NA Homo sapiens
TAX029272
GO:0071046 biological process nuclear polyadenylation dependent ncRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a non (more detail) 6 NA Homo sapiens
TAX029119
GO:0070816 biological process phosphorylation of RNA polymerase II C terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of (more detail) 6 NA Homo sapiens
TAX030076
GO:0072588 cellular component box H/ACA RNP complex A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dy (more detail) 6 NA Homo sapiens
TAX029263
GO:0071029 biological process nuclear ncRNA surveillance The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the n (more detail) 6 NA Homo sapiens
TAX029266
GO:0071035 biological process nuclear polyadenylation dependent rRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a rib (more detail) 6 NA Homo sapiens
WAG000528
Telomere C strand synthesis initiation (more detail) 6 NA Homo sapiens
TAX030808
GO:0097342 cellular component ripoptosome A protein complex whose core components are the receptor-interacting serine/threonine-protein kinase (more detail) 6 NA Homo sapiens
TAX015936
GO:0005787 cellular component signal peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal seque (more detail) 6 NA Homo sapiens
WAG000531
Regulation of pyruvate dehydrogenase complex (PDC) (more detail) 6 NA Homo sapiens
PEX002615
RNase PH C: 3' exoribonuclease family, domain 2 This family includes 3-5 exoribonucleases. Ribonuclease PH contains a single copy of this domain, a (more detail) 6 NA Homo sapiens
TAX013290
GO:0000172 cellular component ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA (more detail) 6 NA Homo sapiens
MEX000536
Genes associated with Approved Drug fludarabine phosphate Genes associated with Approved Drug fludarabine phosphate, curated by the Drug Signature Database (D (more detail) 6 25990557 Homo sapiens
TAX023373
GO:0036402 molecular function proteasome activating ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrat (more detail) 6 NA Homo sapiens
TAX022535
GO:0034513 molecular function box H/ACA snoRNA binding Interacting selectively and non-covalently with box H/ACA small nucleolar RNA. (more detail) 6 NA Homo sapiens
TAX022555
GO:0034603 molecular function pyruvate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. (more detail) 6 NA Homo sapiens
TAX015354
GO:0004738 molecular function pyruvate dehydrogenase activity Catalysis of the oxidative decarboxylation of pyruvate. (more detail) 6 NA Homo sapiens
TAX022556
GO:0034604 molecular function pyruvate dehydrogenase (NAD+) activity Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH. (more detail) 6 NA Homo sapiens
TAX020698
GO:0030891 cellular component VCB complex A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for e (more detail) 6 NA Homo sapiens
PEX002503
Kelch 1: Kelch motif The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copi (more detail) 6 NA Homo sapiens
TAX024490
GO:0043634 biological process polyadenylation dependent ncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, (more detail) 6 NA Homo sapiens
TAX019524
GO:0018344 biological process protein geranylgeranylation The covalent attachment of a geranylgeranyl group to a protein. (more detail) 6 NA Homo sapiens
TAX020987
GO:0031429 cellular component box H/ACA snoRNP complex A box H/ACA RNP complex that is located in the nucleolus. (more detail) 6 NA Homo sapiens
TAX019110
GO:0016589 cellular component NURF complex An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 hom (more detail) 6 NA Homo sapiens
TAX015853
GO:0005658 cellular component alpha DNA polymerase:primase complex A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two pri (more detail) 6 NA Homo sapiens
TAX020507
GO:0030422 biological process production of siRNA involved in RNA interference Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotide (more detail) 6 NA Homo sapiens
TAX020286
GO:0030062 cellular component mitochondrial tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TC (more detail) 6 NA Homo sapiens
TAX019426
GO:0017176 molecular function phosphatidylinositol N acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-gluc (more detail) 6 NA Homo sapiens
PEX000885
Cyclin C: Cyclin, C terminal domain Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is r (more detail) 6 NA Homo sapiens
WAG000686
DNA replication initiation (more detail) 6 NA Homo sapiens
TAX022632
GO:0034715 cellular component pICln Sm protein complex A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, S (more detail) 6 NA Homo sapiens
TAX029262
GO:0071028 biological process nuclear mRNA surveillance The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nu (more detail) 9 NA Homo sapiens
TAX017074
GO:0008121 molecular function ubiquinol cytochrome c reductase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 9 NA Homo sapiens
TAX019162
GO:0016681 molecular function oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts (more detail) 9 NA Homo sapiens
TAX022719
GO:0035068 cellular component micro ribonucleoprotein complex A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucle (more detail) 9 NA Homo sapiens
IEI007339
Protein protein interactors of human gene LMTK2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene LMTK2 (SwissProt ID= (more detail) 7 17535438 Homo sapiens
TAX022800
GO:0035280 biological process miRNA loading onto RISC involved in gene silencing by miRNA The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing (more detail) 7 NA Homo sapiens
TAX021191
GO:0031821 molecular function G protein coupled serotonin receptor binding Interacting selectively and non-covalently with a metabotropic serotonin receptor. (more detail) 7 NA Homo sapiens
TAX018856
GO:0016078 biological process tRNA catabolic process The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of rel (more detail) 7 NA Homo sapiens
WAG000477
Cyclin D associated events in G1 (more detail) 7 NA Homo sapiens
TAX022124
GO:0033503 cellular component HULC complex A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin (more detail) 5 NA Homo sapiens
TAX024419
GO:0043527 cellular component tRNA methyltransferase complex A multimeric protein complex involved in the methylation of specific nucleotides in tRNA. (more detail) 5 NA Homo sapiens
PEX000357
F box like: F box like This is an F-box-like family. (more detail) 5 NA Homo sapiens
TAX034794
GO:2000582 biological process positive regulation of ATP dependent microtubule motor activity, plus end directed Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule m (more detail) 5 NA Homo sapiens
TAX021015
GO:0031467 cellular component Cul7 RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form (more detail) 5 NA Homo sapiens
TAX021013
GO:0031465 cellular component Cul4B RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form (more detail) 5 NA Homo sapiens
TAX014855
GO:0003923 molecular function GPI anchor transamidase activity Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol ancho (more detail) 5 NA Homo sapiens
TAX019034
GO:0016454 molecular function C palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. (more detail) 5 NA Homo sapiens
TAX013529
GO:0000835 cellular component ER ubiquitin ligase complex A ubiquitin ligase complex found in the ER. (more detail) 5 NA Homo sapiens
MOX003166
Genes associated with Computational Drug Signature Inecalcitol Genes associated with Computational Drug Signature Inecalcitol, curated by the Drug Signature Databa (more detail) 5 25990557 Homo sapiens
TAX029267
GO:0071038 biological process nuclear polyadenylation dependent tRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an ab (more detail) 5 NA Homo sapiens
TAX029671
GO:0071797 cellular component LUBAC complex A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targe (more detail) 5 NA Homo sapiens
TAX024724
GO:0044388 molecular function small protein activating enzyme binding Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin (more detail) 5 NA Homo sapiens
TAX020977
GO:0031415 cellular component NatA complex A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, o (more detail) 5 NA Homo sapiens
TAX030955
GO:0097651 cellular component phosphatidylinositol 3 kinase complex, class I A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phos (more detail) 5 NA Homo sapiens
TAX013530
GO:0000836 cellular component Hrd1p ubiquitin ligase complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membran (more detail) 5 NA Homo sapiens
TAX016030
GO:0005947 cellular component mitochondrial alpha ketoglutarate dehydrogenase complex Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity. (more detail) 5 NA Homo sapiens
TAX034793
GO:2000580 biological process regulation of ATP dependent microtubule motor activity, plus end directed Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity (more detail) 5 NA Homo sapiens
MOX015958
Genes associated with Computational Drug Signature ZK CDK Genes associated with Computational Drug Signature ZK CDK, curated by the Drug Signature Database (D (more detail) 5 25990557 Homo sapiens
POX000477
IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 5 NA Homo sapiens
GEX168117
Tsurusaki et al., 2012 03 18, Nature Genetics, Mutations affecting components of the SWI/SNF complex cause Coffin Siris syndrome Coffin-Siris syndrome Mutation type(Germline mutation) (more detail) 5 22426308 Homo sapiens
TAX017376
GO:0008622 cellular component epsilon DNA polymerase complex A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of (more detail) 5 NA Homo sapiens
TAX025036
GO:0045257 cellular component succinate dehydrogenase complex (ubiquinone) The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; invol (more detail) 5 NA Homo sapiens
TAX025049
GO:0045283 cellular component fumarate reductase complex A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise t (more detail) 5 NA Homo sapiens
TAX034163
GO:1990111 cellular component spermatoproteasome complex A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the (more detail) 5 NA Homo sapiens
TAX015904
GO:0005749 cellular component mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial r (more detail) 5 NA Homo sapiens
POX000489
PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 5 NA Homo sapiens
TAX013427
GO:0000459 biological process exonucleolytic trimming involved in rRNA processing Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule. (more detail) 5 NA Homo sapiens
TAX015303
GO:0004661 molecular function protein geranylgeranyltransferase activity Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether li (more detail) 5 NA Homo sapiens
TAX013433
GO:0000467 biological process exonucleolytic trimming to generate mature 3' end of 5.8S rRNA from tricistronic rRNA transcript (SSU rRNA, 5.8S rRNA, LSU rRNA) Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecul (more detail) 5 NA Homo sapiens
TAX013255
GO:0000104 molecular function succinate dehydrogenase activity Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. (more detail) 5 NA Homo sapiens
TAX013267
GO:0000125 cellular component PCAF complex A large multiprotein complex that possesses histone acetyltransferase activity and is involved in re (more detail) 5 NA Homo sapiens
TAX015370
GO:0004758 molecular function serine C palmitoyltransferase activity Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. (more detail) 5 NA Homo sapiens
TAX024006
GO:0042765 cellular component GPI anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the com (more detail) 5 NA Homo sapiens
TAX025047
GO:0045281 cellular component succinate dehydrogenase complex A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur pr (more detail) 5 NA Homo sapiens
TAX013803
GO:0001739 cellular component sex chromatin Chromatin that is part of a sex chromosome. (more detail) 5 NA Homo sapiens
TAX016038
GO:0005964 cellular component phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. (more detail) 5 NA Homo sapiens
TAX015320
GO:0004689 molecular function phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. (more detail) 5 NA Homo sapiens
POX000474
PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 5 NA Homo sapiens
TAX030014
GO:0072487 cellular component MSL complex A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at (more detail) 5 NA Homo sapiens
IEI014526
Protein protein interactors of human gene TXNRD2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TXNRD2 (SwissProt ID (more detail) 8 17535438 Homo sapiens
IEI011862
Protein protein interactors of human gene SCML1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SCML1 (SwissProt ID= (more detail) 8 17535438 Homo sapiens
MEX001975
Genes associated with Kinase Inhibitor 1173900 33 8 Genes associated with Kinase Inhibitor 1173900-33-8, curated by the Drug Signature Database (DSigDB) (more detail) 8 25990557 Homo sapiens
WAG000110
Phosphorylase kinase activates glycogen phosphorylase (more detail) 8 NA Homo sapiens
TAX016121
GO:0006086 biological process acetyl CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. (more detail) 8 NA Homo sapiens
TAX024014
GO:0042775 biological process mitochondrial ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that (more detail) 8 NA Homo sapiens
MAX002393
G1 to S phase regulators significantly changed in DanG cells (pancreatic cancer) treated with Ly294002 [PubChem=3973] , a phosphoinositide 3 kinase (PI3K) inhibitor. The phosphoinositide-3-kinase (PI3K)/AKT signaling pathway controls fundamental processes of cancer (more detail) 8 NA Homo sapiens
MOX012534
Genes associated with Computational Drug Signature Entinostat Genes associated with Computational Drug Signature Entinostat, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
TAX033171
GO:1903862 biological process positive regulation of oxidative phosphorylation Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation. (more detail) 6 NA Homo sapiens
TAX032278
GO:1901857 biological process positive regulation of cellular respiration Any process that activates or increases the frequency, rate or extent of cellular respiration. (more detail) 6 NA Homo sapiens
TAX033931
GO:1905446 biological process regulation of mitochondrial ATP synthesis coupled electron transport Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled elec (more detail) 6 NA Homo sapiens
TAX029277
GO:0071051 biological process polyadenylation dependent snoRNA 3' end processing Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylati (more detail) 6 NA Homo sapiens
TAX019435
GO:0017196 biological process N terminal peptidyl methionine acetylation The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionin (more detail) 6 NA Homo sapiens
TAX025819
GO:0046935 molecular function 1 phosphatidylinositol 3 kinase regulator activity Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. (more detail) 6 NA Homo sapiens
TAX028298
GO:0061087 biological process positive regulation of histone H3 K27 methylation Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3- (more detail) 6 NA Homo sapiens
TAX018939
GO:0016255 biological process attachment of GPI anchor to protein A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant (more detail) 6 NA Homo sapiens
TAX027595
GO:0055131 molecular function C3HC4 type RING finger domain binding Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3 (more detail) 6 NA Homo sapiens
FEX001280
Leukemia Wang03 06genes Table 1. Up-Regulated Genes in NB4 cells (more detail) 6 12890387 Homo sapiens
TAX034792
GO:2000576 biological process positive regulation of microtubule motor activity Any process that activates or increases the frequency, rate or extent of microtubule motor activity. (more detail) 6 NA Homo sapiens
TAX013389
GO:0000389 biological process mRNA 3' splice site recognition Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome (more detail) 6 NA Homo sapiens
TAX017888
GO:0010265 biological process SCF complex assembly The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc (more detail) 6 NA Homo sapiens
TAX030077
GO:0072589 cellular component box H/ACA scaRNP complex A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, (more detail) 4 NA Homo sapiens
IEI010806
Protein protein interactors of human gene PYDC1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PYDC1 (SwissProt ID= (more detail) 4 17535438 Homo sapiens
TAX028689
GO:0070022 cellular component transforming growth factor beta receptor complex A homodimeric receptor complex that consists of two TGF-beta receptor monomers. (more detail) 4 NA Homo sapiens
TAX032863
GO:1903276 biological process regulation of sodium ion export across plasma membrane Any process that modulates the frequency, rate or extent of sodium ion export across the plasma memb (more detail) 4 NA Homo sapiens
TAX029249
GO:0071006 cellular component U2 type catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precataly (more detail) 4 NA Homo sapiens
TAX028490
GO:0061575 molecular function cyclin dependent protein serine/threonine kinase activator activity Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. (more detail) 4 NA Homo sapiens
TAX032864
GO:1903278 biological process positive regulation of sodium ion export across plasma membrane Any process that activates or increases the frequency, rate or extent of sodium ion export across th (more detail) 4 NA Homo sapiens
TAX029269
GO:0071043 biological process CUT metabolic process The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcr (more detail) 4 NA Homo sapiens
TAX029265
GO:0071034 biological process CUT catabolic process The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs (more detail) 4 NA Homo sapiens
TAX033933
GO:1905448 biological process positive regulation of mitochondrial ATP synthesis coupled electron transport Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis (more detail) 4 NA Homo sapiens
IEI008168
Protein protein interactors of human gene MRGPRX1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MRGPRX1 (SwissProt I (more detail) 4 17535438 Homo sapiens
TAX029273
GO:0071047 biological process polyadenylation dependent mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, i (more detail) 4 NA Homo sapiens
TAX029268
GO:0071042 biological process nuclear polyadenylation dependent mRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a mes (more detail) 4 NA Homo sapiens
PEX001061
PI3Ka: Phosphoinositide 3 kinase family, accessory domain (PIK domain) PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested 2 (more detail) 4 NA Homo sapiens
PEX002114
G alpha: G protein alpha subunit G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G prot (more detail) 4 NA Homo sapiens
MOX007766
Genes associated with Computational Drug Signature CHEMBL1088704 Genes associated with Computational Drug Signature CHEMBL1088704, curated by the Drug Signature Data (more detail) 4 25990557 Homo sapiens
MOX010824
Genes associated with Computational Drug Signature CHEMBL471042 Genes associated with Computational Drug Signature CHEMBL471042, curated by the Drug Signature Datab (more detail) 4 25990557 Homo sapiens
TAX021771
GO:0032777 cellular component Piccolo NuA4 histone acetyltransferase complex A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin o (more detail) 4 NA Homo sapiens
TAX023291
GO:0036156 cellular component inner dynein arm Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The (more detail) 4 NA Homo sapiens
TAX016034
GO:0005955 cellular component calcineurin complex A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and r (more detail) 4 NA Homo sapiens
PEX001701
Cullin Nedd8: Cullin protein neddylation domain This is the neddylation site of cullin proteins which are a family of structurally related proteins (more detail) 4 NA Homo sapiens
POX000416
PathwayGeneSet, HumanCyc Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 4 NA Homo sapiens
WAG000897
Oxidative decarboxylation of alpha ketoisovalerate to isobutyryl CoA by branched chain alpha ketoacid dehydrogenase (more detail) 4 NA Homo sapiens
MOX008587
Genes associated with Computational Drug Signature CHEMBL203028 Genes associated with Computational Drug Signature CHEMBL203028, curated by the Drug Signature Datab (more detail) 4 25990557 Homo sapiens
TAX022397
GO:0034271 cellular component phosphatidylinositol 3 kinase complex, class III, type I A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, t (more detail) 4 NA Homo sapiens
TAX030596
GO:0090661 cellular component box H/ACA telomerase RNP complex A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the (more detail) 4 NA Homo sapiens
TAX024481
GO:0043625 cellular component delta DNA polymerase complex A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans i (more detail) 4 NA Homo sapiens
TAX013212
GO:0000015 cellular component phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phosp (more detail) 4 NA Homo sapiens
TAX022828
GO:0035339 cellular component SPOTS complex A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as (more detail) 4 NA Homo sapiens
TAX016265
GO:0006344 biological process maintenance of chromatin silencing The maintenance of chromatin in a transcriptionally silent state such as heterochromatin. (more detail) 4 NA Homo sapiens
TAX020830
GO:0031120 biological process snRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. (more detail) 4 NA Homo sapiens
WAG001515
Oxidative decarboxylation of alpha keto beta methylvalerate to alpha methylbutyryl CoA by branched chain alpha ketoacid dehydrogenase (more detail) 4 NA Homo sapiens
TAX013308
GO:0000214 cellular component tRNA intron endonuclease complex A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and (more detail) 4 NA Homo sapiens
WAG000090
Oxidative decarboxylation of alpha ketoisocaproate to isovaleryl CoA by branched chain alpha ketoacid dehydrogenase (more detail) 4 NA Homo sapiens
TAX022398
GO:0034272 cellular component phosphatidylinositol 3 kinase complex, class III, type II A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) (more detail) 4 NA Homo sapiens
TAX022721
GO:0035087 biological process siRNA loading onto RISC involved in RNA interference The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleav (more detail) 4 NA Homo sapiens
TAX030584
GO:0090625 biological process mRNA cleavage involved in gene silencing by siRNA The process in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incor (more detail) 4 NA Homo sapiens
TAX019521
GO:0018335 biological process protein succinylation The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid r (more detail) 4 NA Homo sapiens
TAX015305
GO:0004663 molecular function Rab geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-prot (more detail) 4 NA Homo sapiens
MOX011820
Genes associated with Computational Drug Signature CHEMBL88332 Genes associated with Computational Drug Signature CHEMBL88332, curated by the Drug Signature Databa (more detail) 4 25990557 Homo sapiens
MOX007844
Genes associated with Computational Drug Signature CHEMBL109796 Genes associated with Computational Drug Signature CHEMBL109796, curated by the Drug Signature Datab (more detail) 4 25990557 Homo sapiens
TAX020433
GO:0030289 cellular component protein phosphatase 4 complex A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatas (more detail) 4 NA Homo sapiens
TAX016041
GO:0005968 cellular component Rab protein geranylgeranyltransferase complex A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and whi (more detail) 4 NA Homo sapiens
MOX015023
Genes associated with Computational Drug Signature sbha Genes associated with Computational Drug Signature sbha, curated by the Drug Signature Database (DSi (more detail) 4 25990557 Homo sapiens
MOX014748
Genes associated with Computational Drug Signature R547 Genes associated with Computational Drug Signature R547, curated by the Drug Signature Database (DSi (more detail) 4 25990557 Homo sapiens
MOX014349
Genes associated with Computational Drug Signature Panobinostat Genes associated with Computational Drug Signature Panobinostat, curated by the Drug Signature Datab (more detail) 4 25990557 Homo sapiens
MOX008252
Genes associated with Computational Drug Signature CHEMBL165162 Genes associated with Computational Drug Signature CHEMBL165162, curated by the Drug Signature Datab (more detail) 4 25990557 Homo sapiens
PEX000032
BACK: BTB And C terminal Kelch This domain is found associated with Pfam:PF00651 and Pfam:PF01344 1. The BACK domain is found juxta (more detail) 4 NA Homo sapiens
POX000405
PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 4 NA Homo sapiens
POX000439
PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 4 NA Homo sapiens
TAX031789
GO:1900060 biological process negative regulation of ceramide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic (more detail) 4 NA Homo sapiens
TAX021026
GO:0031501 cellular component mannosyltransferase complex A complex that posseses mannosyltransferase activity. (more detail) 4 NA Homo sapiens
TAX017661
GO:0009328 cellular component phenylalanine tRNA ligase complex An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl- (more detail) 4 NA Homo sapiens
TAX017107
GO:0008177 molecular function succinate dehydrogenase (ubiquinone) activity Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol. (more detail) 4 NA Homo sapiens
MOX008250
Genes associated with Computational Drug Signature CHEMBL164872 Genes associated with Computational Drug Signature CHEMBL164872, curated by the Drug Signature Datab (more detail) 4 25990557 Homo sapiens
MEX002198
Genes associated with Kinase Inhibitor Cdk/Crk Inhibitor Genes associated with Kinase Inhibitor Cdk/Crk Inhibitor, curated by the Drug Signature Database (DS (more detail) 4 25990557 Homo sapiens
MEX001647
Genes associated with Kinase Inhibitor 503468 95 9 Genes associated with Kinase Inhibitor 503468-95-9, curated by the Drug Signature Database (DSigDB). (more detail) 4 25990557 Homo sapiens
POX000395
IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 4 NA Homo sapiens
TAX015281
GO:0004634 molecular function phosphopyruvate hydratase activity Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. (more detail) 4 NA Homo sapiens
TAX020508
GO:0030423 biological process targeting of mRNA for destruction involved in RNA interference The process in which small interfering RNAs target cognate mRNA molecules for degradation. (more detail) 4 NA Homo sapiens
TAX030365
GO:0090155 biological process negative regulation of sphingolipid biosynthetic process Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid (more detail) 4 NA Homo sapiens
POX000400
IsozymeGeneSet, KEGG Enzyme Genes associated with IsozymeGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 4 NA Homo sapiens
TAX031581
GO:0106077 biological process histone succinylation The modification of a histone by the addition of an succinyl group. (more detail) 4 NA Homo sapiens
MOX007871
Genes associated with Computational Drug Signature CHEMBL111806 Genes associated with Computational Drug Signature CHEMBL111806, curated by the Drug Signature Datab (more detail) 4 25990557 Homo sapiens
TAX016218
GO:0006269 biological process DNA replication, synthesis of RNA primer The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA (more detail) 5 NA Homo sapiens
TAX015421
GO:0004826 molecular function phenylalanine tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tR (more detail) 5 NA Homo sapiens
TAX026956
GO:0051343 biological process positive regulation of cyclic nucleotide phosphodiesterase activity Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodi (more detail) 5 NA Homo sapiens
TAX031132
GO:0098795 biological process mRNA cleavage involved in gene silencing Cleavage of an mRNA occurring as part of the mechanism of gene silencing. (more detail) 5 NA Homo sapiens
TAX020587
GO:0030620 molecular function U2 snRNA binding Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA). (more detail) 5 NA Homo sapiens
TAX019138
GO:0016635 molecular function oxidoreductase activity, acting on the CH CH group of donors, quinone or related compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or el (more detail) 5 NA Homo sapiens
MOX006851
Genes associated with Computational Drug Signature AGN PC 0MWF7I Genes associated with Computational Drug Signature AGN-PC-0MWF7I, curated by the Drug Signature Data (more detail) 5 25990557 Homo sapiens
TAX022799
GO:0035279 biological process mRNA cleavage involved in gene silencing by miRNA The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into (more detail) 5 NA Homo sapiens
POX000486
PathwayGeneSet, Reactome Genes associated with PathwayGeneSet. PAGER constructed this gene-set from an Isozyme study (Bulent (more detail) 5 NA Homo sapiens
MOX013388
Genes associated with Computational Drug Signature LARGAZOLE Genes associated with Computational Drug Signature LARGAZOLE, curated by the Drug Signature Database (more detail) 5 25990557 Homo sapiens
TAX016332
GO:0006432 biological process phenylalanyl tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetas (more detail) 5 NA Homo sapiens
WAG000511
Processive synthesis on the C strand of the telomere (more detail) 5 NA Homo sapiens
MEX001640
Genes associated with Kinase Inhibitor GDC 0941 Genes associated with Kinase Inhibitor GDC-0941, curated by the Drug Signature Database (DSigDB). (more detail) 5 25990557 Homo sapiens
TAX013562
GO:0000965 biological process mitochondrial RNA 3' end processing Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondria (more detail) 5 NA Homo sapiens
IEI014263
Protein protein interactors of human gene TRIM58 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM58 (SwissProt ID (more detail) 5 17535438 Homo sapiens
TAX029136
GO:0070842 biological process aggresome assembly The aggregation, arrangement and bonding together of a set of components to form an aggresome; requi (more detail) 5 NA Homo sapiens
TAX029200
GO:0070940 biological process dephosphorylation of RNA polymerase II C terminal domain The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA (more detail) 5 NA Homo sapiens
IEI009915
Protein protein interactors of human gene PIGU from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PIGU (SwissProt ID=Q (more detail) 5 17535438 Homo sapiens
TAX033742
GO:1905007 biological process positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Any process that activates or increases the frequency, rate or extent of epithelial to mesenchymal t (more detail) 5 NA Homo sapiens
IEI001108
Protein protein interactors of human gene ATP6V0D2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ATP6V0D2 (SwissProt (more detail) 5 17535438 Homo sapiens
IEI011250
Protein protein interactors of human gene RGS18 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RGS18 (SwissProt ID= (more detail) 5 17535438 Homo sapiens
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