Y-U
(more detail)
439 NA Homo sapiens
TAX029048
GO:0070647 biological process protein modification by small protein conjugation or removal A protein modification process in which one or more groups of a small protein, such as ubiquitin or (more detail) 921 NA Homo sapiens
TAX032530
GO:1902494 cellular component catalytic complex A protein complex which is capable of catalytic activity. (more detail) 1315 NA Homo sapiens
TAX000089
Genes annotated by the GO term GO:0044260. The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, as carried out by individual cells. (more detail) 1094 NA Homo sapiens
TAX000096
Genes annotated by the GO term GO:0044267. The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. (more detail) 1080 NA Homo sapiens
TAX022578
GO:0034641 biological process cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, a (more detail) 4908 NA Homo sapiens
TAX024663
GO:0044283 biological process small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of small molecules, any low molecular (more detail) 567 NA Homo sapiens
TAX000053
Genes annotated by the GO term GO:0043412. The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties. (more detail) 634 NA Homo sapiens
TAX016574
GO:0006753 biological process nucleoside phosphate metabolic process The chemical reactions and pathways involving any phosphorylated nucleoside. (more detail) 489 NA Homo sapiens
TAX017518
GO:0009117 biological process nucleotide metabolic process The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (or (more detail) 484 NA Homo sapiens
TAX000557
Genes annotated by the GO term GO:0006464. The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co translational, post translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre translation modification). (more detail) 615 NA Homo sapiens
TAX001431
Genes annotated by the GO term GO:0016772. Catalysis of the transfer of a phosphorus containing group from one compound (donor) to another (acceptor). (more detail) 419 NA Homo sapiens
TAX023908
GO:0042578 molecular function phosphoric ester hydrolase activity Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosph (more detail) 370 NA Homo sapiens
TAX030531
GO:0090407 biological process organophosphate biosynthetic process The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phos (more detail) 546 NA Homo sapiens
TAX000555
Genes annotated by the GO term GO:0019538. The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. (more detail) 1187 NA Homo sapiens
TAX032108
GO:1901360 biological process organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound. (more detail) 4827 NA Homo sapiens
TAX031706
GO:0140098 molecular function catalytic activity, acting on RNA Catalytic activity that acts to modify RNA. (more detail) 361 NA Homo sapiens
TAX023935
GO:0042623 molecular function ATPase activity, coupled Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other rea (more detail) 358 NA Homo sapiens
TAX021555
GO:0032446 biological process protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or (more detail) 671 NA Homo sapiens
TAX026039
GO:0048037 molecular function cofactor binding Interacting selectively and non-covalently with a cofactor, a substance that is required for the act (more detail) 486 NA Homo sapiens
TAX019404
GO:0017144 biological process drug metabolic process The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment o (more detail) 538 NA Homo sapiens
TAX032165
GO:1901565 biological process organonitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. (more detail) 719 NA Homo sapiens
TAX032166
GO:1901566 biological process organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organonitrogen compound. (more detail) 925 NA Homo sapiens
FEX002708
Manning02 624genes ProteinKinases protein kinases : The protein kinase complement of the human genome (more detail) 363 12471243 Homo sapiens
TAX017474
GO:0009058 biological process biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-r (more detail) 4323 NA Homo sapiens
TAX017368
GO:0008610 biological process lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an or (more detail) 562 NA Homo sapiens
TAX026858
GO:0051186 biological process cofactor metabolic process The chemical reactions and pathways involving a cofactor, a substance that is required for the activ (more detail) 476 NA Homo sapiens
TAX019094
GO:0016567 biological process protein ubiquitination The process in which one or more ubiquitin groups are added to a protein. (more detail) 621 NA Homo sapiens
TAX001221
Genes annotated by the GO term GO:0016301. Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. (more detail) 364 NA Homo sapiens
MOX004950
Genes associated with Computational Drug Signature cyclosporin A Genes associated with Computational Drug Signature cyclosporin A, curated by the Drug Signature Data (more detail) 4551 25990557 Homo sapiens
TAX032173
GO:1901576 biological process organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecula (more detail) 4266 NA Homo sapiens
MEX002069
Genes associated with Kinase Inhibitor staurosporine Genes associated with Kinase Inhibitor staurosporine, curated by the Drug Signature Database (DSigDB (more detail) 313 25990557 Homo sapiens
TAX024662
GO:0044282 biological process small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular (more detail) 391 NA Homo sapiens
TAX021779
GO:0032787 biological process monocarboxylic acid metabolic process The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one (more detail) 481 NA Homo sapiens
TAX016555
GO:0006725 biological process cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized (more detail) 4620 NA Homo sapiens
TAX001314
Genes annotated by the GO term GO:0016773. Catalysis of the transfer of a phosphorus containing group from one compound (donor) to an alcohol group (acceptor). (more detail) 329 NA Homo sapiens
TAX000052
Genes annotated by the GO term GO:0043283. The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. (more detail) 1637 NA Homo sapiens
TAX025594
GO:0046483 biological process heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular (more detail) 4579 NA Homo sapiens
TAX000530
Genes annotated by the GO term GO:0043687. The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. (more detail) 462 NA Homo sapiens
TAX019423
GO:0017171 molecular function serine hydrolase activity Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad (more detail) 286 NA Homo sapiens
TAX014856
GO:0003924 molecular function GTPase activity Catalysis of the reaction: GTP + H2O = GDP + phosphate. (more detail) 286 NA Homo sapiens
TAX019198
GO:0016757 molecular function transferase activity, transferring glycosyl groups Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). (more detail) 286 NA Homo sapiens
TAX024645
GO:0044249 biological process cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individ (more detail) 4154 NA Homo sapiens
TAX019779
GO:0019693 biological process ribose phosphate metabolic process The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar. (more detail) 368 NA Homo sapiens
TAX016044
GO:0005975 biological process carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds bas (more detail) 455 NA Homo sapiens
TAX015894
GO:0005737 cellular component cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcell (more detail) 4130 NA Homo sapiens
TAX017144
GO:0008236 molecular function serine type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that in (more detail) 281 NA Homo sapiens
TAX030032
GO:0072521 biological process purine containing compound metabolic process The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that c (more detail) 388 NA Homo sapiens
TAX019220
GO:0016791 molecular function phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. (more detail) 278 NA Homo sapiens
TAX032021
GO:1901137 biological process carbohydrate derivative biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrate derivative. (more detail) 443 NA Homo sapiens
TAX001280
Genes annotated by the GO term GO:0016491. Catalysis of an oxidation reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. (more detail) 285 NA Homo sapiens
MEX002285
Genes associated with Kinase Inhibitor Lestaurtinib Genes associated with Kinase Inhibitor Lestaurtinib, curated by the Drug Signature Database (DSigDB) (more detail) 270 25990557 Homo sapiens
TAX016160
GO:0006163 biological process purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleosi (more detail) 354 NA Homo sapiens
TAX017636
GO:0009259 biological process ribonucleotide metabolic process The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleos (more detail) 351 NA Homo sapiens
TAX027156
GO:0051716 biological process cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 2605 NA Homo sapiens
TAX016695
GO:0006950 biological process response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 2884 NA Homo sapiens
TAX034193
GO:1990234 cellular component transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group (more detail) 724 NA Homo sapiens
MEX000996
Genes associated with Approved Drug sunitinib Genes associated with Approved Drug sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 256 25990557 Homo sapiens
TAX018972
GO:0016311 biological process dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. (more detail) 296 NA Homo sapiens
TAX025806
GO:0046914 molecular function transition metal ion binding Interacting selectively and non-covalently with a transition metal ions; a transition metal is an el (more detail) 1053 NA Homo sapiens
TAX017548
GO:0009150 biological process purine ribonucleotide metabolic process The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribo (more detail) 336 NA Homo sapiens
TAX015037
GO:0004252 molecular function serine type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic m (more detail) 251 NA Homo sapiens
TAX028687
GO:0070013 cellular component intracellular organelle lumen An organelle lumen that is part of an intracellular organelle. (more detail) 1199 NA Homo sapiens
TAX024242
GO:0043233 cellular component organelle lumen The internal volume enclosed by the membranes of a particular organelle; includes the volume enclose (more detail) 1199 NA Homo sapiens
TAX021260
GO:0031974 cellular component membrane enclosed lumen The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume (more detail) 1199 NA Homo sapiens
MEX001673
Genes associated with Kinase Inhibitor SureCN1564574 Genes associated with Kinase Inhibitor SureCN1564574, curated by the Drug Signature Database (DSigDB (more detail) 254 25990557 Homo sapiens
TAX001329
Genes annotated by the GO term GO:0004672. Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. (more detail) 281 NA Homo sapiens
FEX012428
The normalized gene expressions no less than 30 in the tissue of liver. Consensus transcript expression levels summarized per gene in 62 tissues based on transcriptomics da (more detail) 2824 25613900 Homo sapiens
TAX019192
GO:0016746 molecular function transferase activity, transferring acyl groups Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). (more detail) 246 NA Homo sapiens
TAX026498
GO:0050662 molecular function coenzyme binding Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofact (more detail) 275 NA Homo sapiens
TAX016151
GO:0006139 biological process nucleobase containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. (more detail) 4414 NA Homo sapiens
TAX001198
Genes annotated by the GO term GO:0016788. Catalysis of the hydrolysis of any ester bond. (more detail) 262 NA Homo sapiens
MOX004729
Genes associated with Computational Drug Signature Tetradioxin Genes associated with Computational Drug Signature Tetradioxin, curated by the Drug Signature Databa (more detail) 3601 25990557 Homo sapiens
TAX022135
GO:0033554 biological process cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 1453 NA Homo sapiens
MOX000853
Genes associated with Computational Drug Signature 7646 79 9 Genes associated with Computational Drug Signature 7646-79-9, curated by the Drug Signature Database (more detail) 2952 25990557 Homo sapiens
TAX028530
GO:0061659 molecular function ubiquitin like protein ligase activity Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction (more detail) 236 NA Homo sapiens
TAX016495
GO:0006644 biological process phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as (more detail) 402 NA Homo sapiens
TAX016559
GO:0006732 biological process coenzyme metabolic process The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors (more detail) 303 NA Homo sapiens
TAX028518
GO:0061630 molecular function ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X (more detail) 231 NA Homo sapiens
MEX001467
Genes associated with Kinase Inhibitor OTSSP167 Genes associated with Kinase Inhibitor OTSSP167, curated by the Drug Signature Database (DSigDB). (more detail) 234 25990557 Homo sapiens
TAX017473
GO:0009057 biological process macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of h (more detail) 907 NA Homo sapiens
TAX015911
GO:0005759 cellular component mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of (more detail) 352 NA Homo sapiens
TAX024744
GO:0044428 cellular component nuclear part Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chrom (more detail) 4273 NA Homo sapiens
TAX018843
GO:0016053 biological process organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound (more detail) 313 NA Homo sapiens
TAX016598
GO:0006790 biological process sulfur compound metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that conta (more detail) 352 NA Homo sapiens
TAX019188
GO:0016741 molecular function transferase activity, transferring one carbon groups Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). (more detail) 224 NA Homo sapiens
TAX025552
GO:0046394 biological process carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid (more detail) 312 NA Homo sapiens
TAX015196
GO:0004518 molecular function nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids. (more detail) 221 NA Homo sapiens
TAX013903
GO:0001882 molecular function nucleoside binding Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or p (more detail) 374 NA Homo sapiens
TAX021626
GO:0032549 molecular function ribonucleoside binding Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine (more detail) 367 NA Homo sapiens
TAX015895
GO:0005739 cellular component mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in th (more detail) 1146 NA Homo sapiens
TAX019569
GO:0019001 molecular function guanyl nucleotide binding Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guano (more detail) 377 NA Homo sapiens
TAX021638
GO:0032561 molecular function guanyl ribonucleotide binding Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of (more detail) 377 NA Homo sapiens
TAX016388
GO:0006520 biological process cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more a (more detail) 288 NA Homo sapiens
TAX019193
GO:0016747 molecular function transferase activity, transferring acyl groups other than amino acyl groups Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to anot (more detail) 216 NA Homo sapiens
TAX025596
GO:0046486 biological process glycerolipid metabolic process The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Dia (more detail) 400 NA Homo sapiens
TAX015789
GO:0005525 molecular function GTP binding Interacting selectively and non-covalently with GTP, guanosine triphosphate. (more detail) 362 NA Homo sapiens
TAX013904
GO:0001883 molecular function purine nucleoside binding Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a puri (more detail) 366 NA Homo sapiens
TAX001193
Genes annotated by the GO term GO:0016817. Catalysis of the hydrolysis of any acid anhydride. (more detail) 223 NA Homo sapiens
TAX027094
GO:0051603 biological process proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pat (more detail) 526 NA Homo sapiens
TAX021627
GO:0032550 molecular function purine ribonucleoside binding Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a (more detail) 363 NA Homo sapiens
TAX021916
GO:0032991 cellular component protein containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipi (more detail) 4915 NA Homo sapiens
TAX017098
GO:0008168 molecular function methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule. (more detail) 213 NA Homo sapiens
TAX001345
Genes annotated by the GO term GO:0016462. Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. (more detail) 221 NA Homo sapiens
TAX000868
Genes annotated by the GO term GO:0005737. All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. (more detail) 2023 NA Homo sapiens
TAX024745
GO:0044429 cellular component mitochondrial part Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in (more detail) 982 NA Homo sapiens
TAX019199
GO:0016758 molecular function transferase activity, transferring hexosyl groups Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). (more detail) 207 NA Homo sapiens
WIG000977
Genes involved in Metabolism of lipids and lipoproteins (more detail) 458 NA Homo sapiens
TAX016485
GO:0006631 biological process fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated (more detail) 294 NA Homo sapiens
MEX001791
Genes associated with Kinase Inhibitor NVP TAE684 Genes associated with Kinase Inhibitor NVP-TAE684, curated by the Drug Signature Database (DSigDB). (more detail) 210 25990557 Homo sapiens
FEX012489
The normalized gene expressions no less than 30 in the tissue of liver from the Human Protein Atlas. Transcript expression levels summarized per gene in 37 tissues based on RNA-seq. The tab-separated f (more detail) 1997 25613900 Homo sapiens
MOX004611
Genes associated with Computational Drug Signature quercetin Genes associated with Computational Drug Signature quercetin, curated by the Drug Signature Database (more detail) 3000 25990557 Homo sapiens
MOX003727
Genes associated with Computational Drug Signature benzo[a]pyrene Genes associated with Computational Drug Signature benzo[a]pyrene, curated by the Drug Signature Dat (more detail) 4201 25990557 Homo sapiens
TAX024239
GO:0043230 cellular component extracellular organelle Organized structure of distinctive morphology and function, occurring outside the cell. Includes, fo (more detail) 2042 NA Homo sapiens
MEX001224
Genes associated with Kinase Inhibitor NVP TAE684 Genes associated with Kinase Inhibitor NVP-TAE684, curated by the Drug Signature Database (DSigDB). (more detail) 203 25990557 Homo sapiens
MEX001635
Genes associated with Kinase Inhibitor BX 912 Genes associated with Kinase Inhibitor BX-912, curated by the Drug Signature Database (DSigDB). (more detail) 203 25990557 Homo sapiens
TAX033013
GO:1903561 cellular component extracellular vesicle Any vesicle that is part of the extracellular region. (more detail) 2041 NA Homo sapiens
TAX028707
GO:0070062 cellular component extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membran (more detail) 2021 NA Homo sapiens
MOX003614
Genes associated with Computational Drug Signature acetaminophen Genes associated with Computational Drug Signature acetaminophen, curated by the Drug Signature Data (more detail) 3910 25990557 Homo sapiens
MEX001522
Genes associated with Kinase Inhibitor 841290 80 0 Genes associated with Kinase Inhibitor 841290-80-0, curated by the Drug Signature Database (DSigDB). (more detail) 201 25990557 Homo sapiens
TAX017142
GO:0008234 molecular function cysteine type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulf (more detail) 200 NA Homo sapiens
TAX001271
Genes annotated by the GO term GO:0017111. Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. (more detail) 207 NA Homo sapiens
MEX001777
Genes associated with Kinase Inhibitor HG 14 10 04 Genes associated with Kinase Inhibitor HG-14-10-04, curated by the Drug Signature Database (DSigDB). (more detail) 202 25990557 Homo sapiens
FEX002230
Lymphoma Melendez05 4229genes SuppTable 1. This file contains row genomic and expression data for each gene. Each gene is identifi (more detail) 2478 15656903 Homo sapiens
TAX032078
GO:1901293 biological process nucleoside phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. (more detail) 264 NA Homo sapiens
TAX016498
GO:0006650 biological process glycerophospholipid metabolic process The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophospha (more detail) 332 NA Homo sapiens
IEI006058
Protein protein interactors of human gene HSP90AA1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene HSP90AA1 (SwissProt (more detail) 831 17535438 Homo sapiens
FEX003014
StemCell Nilsson07 3742genes Table S1. Genes sorted as up-regulated and down-regulated in normal CD34+CD38?Thy-1+ stem cells com (more detail) 3280 17616640 Homo sapiens
TAX031705
GO:0140097 molecular function catalytic activity, acting on DNA Catalytic activity that acts to modify DNA. (more detail) 195 NA Homo sapiens
MEX001653
Genes associated with Kinase Inhibitor staurosporine Genes associated with Kinase Inhibitor staurosporine, curated by the Drug Signature Database (DSigDB (more detail) 195 25990557 Homo sapiens
MEX000995
Genes associated with Approved Drug bosutinib Genes associated with Approved Drug bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 199 25990557 Homo sapiens
TAX017562
GO:0009165 biological process nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that i (more detail) 262 NA Homo sapiens
TAX021263
GO:0031982 cellular component vesicle Any small, fluid-filled, spherical organelle enclosed by membrane. (more detail) 3043 NA Homo sapiens
TAX020805
GO:0031090 cellular component organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane (more detail) 2659 NA Homo sapiens
TAX023723
GO:0042221 biological process response to chemical Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 2510 NA Homo sapiens
MEX002024
Genes associated with Kinase Inhibitor 841290 80 0 Genes associated with Kinase Inhibitor 841290-80-0, curated by the Drug Signature Database (DSigDB). (more detail) 192 25990557 Homo sapiens
FEX012567
The normalized gene expressions no less than 30 in the tissue of liver from the Function Annotation of the Mammalian Genome project. Transcript expression levels summarized per gene in 60 tissues based on CAGE data. The tab-separated (more detail) 2338 25613900 Homo sapiens
TAX020411
GO:0030258 biological process lipid modification The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properti (more detail) 243 NA Homo sapiens
TAX001337
Genes annotated by the GO term GO:0004674. Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. (more detail) 202 NA Homo sapiens
TAX013304
GO:0000209 biological process protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. (more detail) 237 NA Homo sapiens
IEI006060
Protein protein interactors of human gene HSP90AB1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene HSP90AB1 (SwissProt (more detail) 703 17535438 Homo sapiens
TAX019243
GO:0016829 molecular function lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxid (more detail) 187 NA Homo sapiens
TAX015343
GO:0004721 molecular function phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kin (more detail) 187 NA Homo sapiens
TAX018844
GO:0016054 biological process organic acid catabolic process The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound (more detail) 236 NA Homo sapiens
TAX025553
GO:0046395 biological process carboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid (more detail) 236 NA Homo sapiens
TAX025737
GO:0046777 biological process protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylat (more detail) 198 NA Homo sapiens
TAX016124
GO:0006091 biological process generation of precursor metabolites and energy The chemical reactions and pathways resulting in the formation of precursor metabolites, substances (more detail) 351 NA Homo sapiens
MEX002397
Genes associated with Kinase Inhibitor Sunitinib Genes associated with Kinase Inhibitor Sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 185 25990557 Homo sapiens
TAX017145
GO:0008237 molecular function metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, on (more detail) 185 NA Homo sapiens
TAX024652
GO:0044265 biological process cellular macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecul (more detail) 750 NA Homo sapiens
TAX015849
GO:0005654 cellular component nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus. (more detail) 3045 NA Homo sapiens
TAX016210
GO:0006259 biological process DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of (more detail) 752 NA Homo sapiens
MEX002276
Genes associated with Kinase Inhibitor Sunitinib Genes associated with Kinase Inhibitor Sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 183 25990557 Homo sapiens
TAX021416
GO:0032259 biological process methylation The process in which a methyl group is covalently attached to a molecule. (more detail) 286 NA Homo sapiens
MEX001215
Genes associated with Kinase Inhibitor KW 2449 Genes associated with Kinase Inhibitor KW-2449, curated by the Drug Signature Database (DSigDB). (more detail) 182 25990557 Homo sapiens
TAX015338
GO:0004713 molecular function protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. (more detail) 181 NA Homo sapiens
TAX024488
GO:0043632 biological process modification dependent macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by cova (more detail) 464 NA Homo sapiens
FOX000545
Genes in the cancer module 212 (more detail) 317 NA Homo sapiens
TAX024467
GO:0043603 biological process cellular amide metabolic process The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an aci (more detail) 584 NA Homo sapiens
TAX032188
GO:1901615 biological process organic hydroxy compound metabolic process The chemical reactions and pathways involving organic hydroxy compound. (more detail) 418 NA Homo sapiens
MOX004058
Genes associated with Computational Drug Signature estradiol Genes associated with Computational Drug Signature estradiol, curated by the Drug Signature Database (more detail) 4154 25990557 Homo sapiens
TAX013346
GO:0000287 molecular function magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions. (more detail) 201 NA Homo sapiens
FEX012390
The genes express in medium or high level in at least 95% samples in thyroid cancer. Staining profiles for proteins in human tumor tissue based on immunohistochemisty using tissue micro (more detail) 3907 28818916 Homo sapiens
TAX019096
GO:0016570 biological process histone modification The covalent alteration of one or more amino acid residues within a histone protein. (more detail) 352 NA Homo sapiens
TAX000469
Genes annotated by the GO term GO:0016310. The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. (more detail) 303 NA Homo sapiens
TAX019889
GO:0019941 biological process modification dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 454 NA Homo sapiens
TAX019095
GO:0016569 biological process covalent chromatin modification The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups (more detail) 362 NA Homo sapiens
TAX024739
GO:0044421 cellular component extracellular region part Any constituent part of the extracellular region, the space external to the outermost structure of a (more detail) 3267 NA Homo sapiens
FEX000791
Breast Walker10 3588genes SuppTable 1. List of genes and their associated significance levels from three different analyses. (more detail) 2815 20174566 Homo sapiens
TAX015938
GO:0005789 cellular component endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. (more detail) 910 NA Homo sapiens
TAX032180
GO:1901605 biological process alpha amino acid metabolic process The chemical reactions and pathways involving an alpha-amino acid. (more detail) 206 NA Homo sapiens
TAX030478
GO:0090305 biological process nucleic acid phosphodiester bond hydrolysis The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved (more detail) 292 NA Homo sapiens
TAX016382
GO:0006511 biological process ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 448 NA Homo sapiens
FEX000341
Breast Reyal05 3373genesSuppTable2SuppTable2 Table 2: Complete list of genes for which the TC score is above the threshold for the transcription (more detail) 2855 15735024 Homo sapiens
FEX000354
Breast Farmer05 3198genes basal apocrine luminal most discriminant genes by Wilcoxon test for each pairwise comparison in our data (luminal vs basal (more detail) 2895 15897907 Homo sapiens
TAX026860
GO:0051188 biological process cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is re (more detail) 222 NA Homo sapiens
TAX024748
GO:0044432 cellular component endoplasmic reticulum part Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible (more detail) 1289 NA Homo sapiens
TAX028675
GO:0065008 biological process regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological (more detail) 3367 NA Homo sapiens
TAX000540
Genes annotated by the GO term GO:0006468. The process of introducing a phosphate group on to a protein. (more detail) 270 NA Homo sapiens
TAX016353
GO:0006470 biological process protein dephosphorylation The process of removing one or more phosphoric residues from a protein. (more detail) 203 NA Homo sapiens
TAX026893
GO:0051246 biological process regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 2724 NA Homo sapiens
PEX001788
Pkinase: Protein kinase domain (more detail) 165 NA Homo sapiens
WIG002030
metapathway biotransformation metapathway biotransformation (more detail) 174 NA Homo sapiens
TAX001296
Genes annotated by the GO term GO:0008233. Catalysis of the hydrolysis of peptide bonds. (more detail) 169 NA Homo sapiens
TAX032109
GO:1901361 biological process organic cyclic compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. (more detail) 485 NA Homo sapiens
MOX004342
Genes associated with Computational Drug Signature METHYL METHANESULFONATE Genes associated with Computational Drug Signature METHYL METHANESULFONATE, curated by the Drug Sign (more detail) 3627 25990557 Homo sapiens
TAX022935
GO:0035556 biological process intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become ac (more detail) 1481 NA Homo sapiens
TAX019166
GO:0016705 molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred (more detail) 159 NA Homo sapiens
FOX000852
Genes in the cancer module 93 (more detail) 179 NA Homo sapiens
MEX002417
Genes associated with Kinase Inhibitor Nintedanib Genes associated with Kinase Inhibitor Nintedanib, curated by the Drug Signature Database (DSigDB). (more detail) 158 25990557 Homo sapiens
MEX002280
Genes associated with Kinase Inhibitor Vargatef Genes associated with Kinase Inhibitor Vargatef, curated by the Drug Signature Database (DSigDB). (more detail) 158 25990557 Homo sapiens
TAX017409
GO:0008757 molecular function S adenosylmethionine dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. (more detail) 157 NA Homo sapiens
FEX012535
The normalized gene expressions no less than 30 in the tissue of liver from the Gene Tissue Expression project. Transcript expression levels summarized per gene in 36 tissues based on RNA-seq. The tab-separated f (more detail) 1763 25613900 Homo sapiens
TAX019498
GO:0018212 biological process peptidyl tyrosine modification The modification of peptidyl-tyrosine. (more detail) 193 NA Homo sapiens
TAX018834
GO:0016042 biological process lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an or (more detail) 264 NA Homo sapiens
MEX001450
Genes associated with Kinase Inhibitor 602306 29 6 Genes associated with Kinase Inhibitor 602306-29-6, curated by the Drug Signature Database (DSigDB). (more detail) 154 25990557 Homo sapiens
TAX015109
GO:0004386 molecular function helicase activity Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix (more detail) 154 NA Homo sapiens
TAX017393
GO:0008654 biological process phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containin (more detail) 259 NA Homo sapiens
MAX000642
Genes up regulated in CD34+ [GeneID=947] cells isolated from bone marrow of CML (chronic myelogenous leukemia) patients, compared to those from normal donors. In this study, we provide a molecular signature of highly enriched CD34+ cells from bone marrow of u (more detail) 1314 NA Homo sapiens
TAX019463
GO:0018108 biological process peptidyl tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. (more detail) 190 NA Homo sapiens
FEX002890
StemCell Bhattacharya05 2843genes Supplementary Table 1Sa. Overexpression of genes ( (more detail) 2352 16207381 Homo sapiens
TAX001343
Genes annotated by the GO term GO:0017076. Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. (more detail) 204 NA Homo sapiens
WIG001072
Genes involved in Phospholipid metabolism (more detail) 186 NA Homo sapiens
TAX019259
GO:0016853 molecular function isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic na (more detail) 151 NA Homo sapiens
MEX001768
Genes associated with Kinase Inhibitor HG 9 91 01 Genes associated with Kinase Inhibitor HG-9-91-01, curated by the Drug Signature Database (DSigDB). (more detail) 150 25990557 Homo sapiens
TAX029699
GO:0071840 biological process cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of c (more detail) 4929 NA Homo sapiens
TAX018835
GO:0016043 biological process cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellul (more detail) 4875 NA Homo sapiens
TAX019726
GO:0019439 biological process aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance (more detail) 454 NA Homo sapiens
MEX002012
Genes associated with Kinase Inhibitor Foretinib Genes associated with Kinase Inhibitor Foretinib, curated by the Drug Signature Database (DSigDB). (more detail) 149 25990557 Homo sapiens
FEX001146
Immune Kong10 2491genes ImmPort CD40LandAnti IgMvsControl ImmPort genelist of B Cell Stimulation: CD40L and Anti-IgM vs. Control (more detail) 1515 20460173 Homo sapiens
TAX000310
Genes annotated by the GO term GO:0006629. The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty acid esters, and soaps; long chain (fatty) alcohols and waxes; sphingoids and other long chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. (more detail) 321 NA Homo sapiens
TAX022473
GO:0034404 biological process nucleobase containing small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase-containing small mole (more detail) 148 NA Homo sapiens
MEX001293
Genes associated with Kinase Inhibitor AST 487 Genes associated with Kinase Inhibitor AST 487, curated by the Drug Signature Database (DSigDB). (more detail) 147 25990557 Homo sapiens
TAX024893
GO:0045017 biological process glycerolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a gl (more detail) 234 NA Homo sapiens
MEX001676
Genes associated with Kinase Inhibitor 627908 92 3 Genes associated with Kinase Inhibitor 627908-92-3, curated by the Drug Signature Database (DSigDB). (more detail) 146 25990557 Homo sapiens
TAX001272
Genes annotated by the GO term GO:0000166. Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. (more detail) 217 NA Homo sapiens
TAX001344
Genes annotated by the GO term GO:0032555. Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. (more detail) 198 NA Homo sapiens
MEX001712
Genes associated with Kinase Inhibitor HG6 64 1 Genes associated with Kinase Inhibitor HG6-64-1, curated by the Drug Signature Database (DSigDB). (more detail) 145 25990557 Homo sapiens
TAX019231
GO:0016810 molecular function hydrolase activity, acting on carbon nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. (more detail) 145 NA Homo sapiens
WIG000603
Purine metabolism (more detail) 149 NA Homo sapiens
FEX003015
StemCell Nilsson07 3153genes Table S3. Genes ranked by differential expression in 5q- CD34+CD38?Thy-1+ stem cells compared to no (more detail) 2745 17616640 Homo sapiens
WAG000376
Purine metabolism (more detail) 144 NA Homo sapiens
TAX017118
GO:0008194 molecular function UDP glycosyltransferase activity Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. (more detail) 144 NA Homo sapiens
TAX025598
GO:0046488 biological process phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a (more detail) 208 NA Homo sapiens
TAX017521
GO:0009123 biological process nucleoside monophosphate metabolic process The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a (more detail) 177 NA Homo sapiens
TAX025562
GO:0046434 biological process organophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-co (more detail) 153 NA Homo sapiens
MEX001115
Genes associated with Approved Drug crizotinib Genes associated with Approved Drug crizotinib, curated by the Drug Signature Database (DSigDB). (more detail) 146 25990557 Homo sapiens
TAX019495
GO:0018209 biological process peptidyl serine modification The modification of peptidyl-serine. (more detail) 194 NA Homo sapiens
TAX017841
GO:0010033 biological process response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 2019 NA Homo sapiens
TAX019272
GO:0016874 molecular function ligase activity Catalysis of the joining of two substances, or two groups within a single molecule, with the concomi (more detail) 141 NA Homo sapiens
TAX019460
GO:0018105 biological process peptidyl serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. (more detail) 175 NA Homo sapiens
TAX026202
GO:0048522 biological process positive regulation of cellular process Any process that activates or increases the frequency, rate or extent of a cellular process, any of (more detail) 4935 NA Homo sapiens
TAX016708
GO:0006974 biological process cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 703 NA Homo sapiens
TAX024654
GO:0044270 biological process cellular nitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous (more detail) 440 NA Homo sapiens
MEX002396
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 140 25990557 Homo sapiens
TAX025550
GO:0046390 biological process ribose phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylat (more detail) 193 NA Homo sapiens
TAX000086
Genes annotated by the GO term GO:0044255. The chemical reactions and pathways involving lipids, as carried out by individual cells. (more detail) 252 NA Homo sapiens
TAX016109
GO:0006066 biological process alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one o (more detail) 284 NA Homo sapiens
TAX015197
GO:0004519 molecular function endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. (more detail) 138 NA Homo sapiens
MEX002010
Genes associated with Kinase Inhibitor MLS006011171 Genes associated with Kinase Inhibitor MLS006011171, curated by the Drug Signature Database (DSigDB) (more detail) 142 25990557 Homo sapiens
TAX030033
GO:0072522 biological process purine containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. (more detail) 192 NA Homo sapiens
TAX017162
GO:0008270 molecular function zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions. (more detail) 801 NA Homo sapiens
TAX025717
GO:0046700 biological process heterocycle catabolic process The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with (more detail) 438 NA Homo sapiens
TAX001311
Genes annotated by the GO term GO:0042578. Catalysis of the reaction: RPO R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. (more detail) 148 NA Homo sapiens
MEX002403
Genes associated with Kinase Inhibitor Crizotinib Genes associated with Kinase Inhibitor Crizotinib, curated by the Drug Signature Database (DSigDB). (more detail) 137 25990557 Homo sapiens
FEX002495
Ovarian Crijns09 2394Genes 17PathwayPredictor Table S4.Genes from 17 pathways to be related to survival in 157 advanced stage serous ovarian cance (more detail) 1552 19192944 Homo sapiens
TAX028722
GO:0070085 biological process glycosylation The covalent attachment and further modification of carbohydrate residues to a substrate molecule. (more detail) 244 NA Homo sapiens
TAX025588
GO:0046474 biological process glycerophospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivati (more detail) 222 NA Homo sapiens
TAX019210
GO:0016779 molecular function nucleotidyltransferase activity Catalysis of the transfer of a nucleotidyl group to a reactant. (more detail) 136 NA Homo sapiens
MEX001285
Genes associated with Kinase Inhibitor WH 4 023 Genes associated with Kinase Inhibitor WH-4-023, curated by the Drug Signature Database (DSigDB). (more detail) 136 25990557 Homo sapiens
TAX014789
GO:0003774 molecular function motor activity Catalysis of the generation of force resulting either in movement along a microfilament or microtubu (more detail) 135 NA Homo sapiens
TAX027427
GO:0052689 molecular function carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond. (more detail) 135 NA Homo sapiens
MEX001421
Genes associated with Kinase Inhibitor Crizotinib Genes associated with Kinase Inhibitor Crizotinib, curated by the Drug Signature Database (DSigDB). (more detail) 135 25990557 Homo sapiens
TAX000870
Genes annotated by the GO term GO:0044444. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. (more detail) 1322 NA Homo sapiens
TAX019492
GO:0018205 biological process peptidyl lysine modification The modification of peptidyl-lysine. (more detail) 256 NA Homo sapiens
TAX017510
GO:0009108 biological process coenzyme biosynthetic process The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprote (more detail) 171 NA Homo sapiens
MEX002888
Genes associated with Perturbagen Signature clindamycin Genes associated with Perturbagen Signature clindamycin, curated by the Drug Signature Database (DSi (more detail) 1553 25990557 Homo sapiens
TAX032213
GO:1901657 biological process glycosyl compound metabolic process The chemical reactions and pathways involving glycosyl compound. (more detail) 145 NA Homo sapiens
TAX017637
GO:0009260 biological process ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consi (more detail) 188 NA Homo sapiens
TAX016441
GO:0006575 biological process cellular modified amino acid metabolic process The chemical reactions and pathways involving compounds derived from amino acids, organic acids cont (more detail) 195 NA Homo sapiens
FEX000523
Breast Larsson07 3085genes Supplementary table 2. Translationally regulated genes. (more detail) 1977 17638893 Homo sapiens
MOX004956
Genes associated with Computational Drug Signature AFLATOXIN B1 Genes associated with Computational Drug Signature AFLATOXIN B1, curated by the Drug Signature Datab (more detail) 2934 25990557 Homo sapiens
TAX000072
Genes annotated by the GO term GO:0009056. The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. (more detail) 221 NA Homo sapiens
FEX012447
The normalized gene expressions no less than 30 in the tissue of skeletal muscle. Consensus transcript expression levels summarized per gene in 62 tissues based on transcriptomics da (more detail) 3023 25613900 Homo sapiens
TAX024355
GO:0043413 biological process macromolecule glycosylation The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polyn (more detail) 233 NA Homo sapiens
TAX016365
GO:0006486 biological process protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate deriva (more detail) 233 NA Homo sapiens
MEX001848
Genes associated with Kinase Inhibitor Tg 101348 Genes associated with Kinase Inhibitor Tg-101348, curated by the Drug Signature Database (DSigDB). (more detail) 132 25990557 Homo sapiens
TAX026231
GO:0048583 biological process regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to st (more detail) 4003 NA Homo sapiens
TAX000079
Genes annotated by the GO term GO:0044248. The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. (more detail) 208 NA Homo sapiens
TAX019811
GO:0019783 molecular function ubiquitin like protein specific protease activity Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin o (more detail) 131 NA Homo sapiens
TAX030184
GO:0080134 biological process regulation of response to stress Any process that modulates the frequency, rate or extent of a response to stress. Response to stress (more detail) 1361 NA Homo sapiens
TAX029959
GO:0072330 biological process monocarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic (more detail) 197 NA Homo sapiens
TAX019128
GO:0016614 molecular function oxidoreductase activity, acting on CH OH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or ele (more detail) 129 NA Homo sapiens
TAX024356
GO:0043414 biological process macromolecule methylation The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynuc (more detail) 226 NA Homo sapiens
FOX000572
Genes in the cancer module 244 (more detail) 179 NA Homo sapiens
TAX001069
Genes annotated by the GO term GO:0030554. Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. (more detail) 164 NA Homo sapiens
TAX017539
GO:0009141 biological process nucleoside triphosphate metabolic process The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a (more detail) 164 NA Homo sapiens
TAX021421
GO:0032268 biological process regulation of cellular protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 2479 NA Homo sapiens
IEI008723
Protein protein interactors of human gene NEDD8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NEDD8 (SwissProt ID= (more detail) 1043 17535438 Homo sapiens
TAX032168
GO:1901568 biological process fatty acid derivative metabolic process The chemical reactions and pathways involving fatty acid derivative. (more detail) 152 NA Homo sapiens
MOX004199
Genes associated with Computational Drug Signature hydrogen peroxide Genes associated with Computational Drug Signature hydrogen peroxide, curated by the Drug Signature (more detail) 2527 25990557 Homo sapiens
WIG000727
Genes involved in Biological oxidations (more detail) 137 NA Homo sapiens
TAX024393
GO:0043492 molecular function ATPase activity, coupled to movement of substances Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substan (more detail) 126 NA Homo sapiens
MEX001551
Genes associated with Kinase Inhibitor AZD4547 Genes associated with Kinase Inhibitor AZD4547, curated by the Drug Signature Database (DSigDB). (more detail) 126 25990557 Homo sapiens
TAX016161
GO:0006164 biological process purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound co (more detail) 179 NA Homo sapiens
TAX020227
GO:0022900 biological process electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors (more detail) 156 NA Homo sapiens
MEX002327
Genes associated with Kinase Inhibitor Midostaurin Genes associated with Kinase Inhibitor Midostaurin, curated by the Drug Signature Database (DSigDB). (more detail) 125 25990557 Homo sapiens
MEX001881
Genes associated with Kinase Inhibitor K 252a, Nocardiopsis sp. Genes associated with Kinase Inhibitor K-252a, Nocardiopsis sp., curated by the Drug Signature Datab (more detail) 125 25990557 Homo sapiens
TAX017558
GO:0009161 biological process ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting (more detail) 158 NA Homo sapiens
TAX019224
GO:0016798 molecular function hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond. (more detail) 123 NA Homo sapiens
TAX031464
GO:0101005 molecular function ubiquitinyl hydrolase activity Catalysis of the hydrolysis of ubiquitin from proteins and other molecules. (more detail) 123 NA Homo sapiens
MAX001957
Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 401 NA Homo sapiens
TAX001070
Genes annotated by the GO term GO:0032559. Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. (more detail) 158 NA Homo sapiens
TAX023391
GO:0036459 molecular function thiol dependent ubiquitinyl hydrolase activity Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bon (more detail) 122 NA Homo sapiens
TAX017550
GO:0009152 biological process purine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compoun (more detail) 175 NA Homo sapiens
TAX016226
GO:0006281 biological process DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical ag (more detail) 456 NA Homo sapiens
MOX004785
Genes associated with Computational Drug Signature Retinoic acid Genes associated with Computational Drug Signature Retinoic acid, curated by the Drug Signature Data (more detail) 4092 25990557 Homo sapiens
TAX018964
GO:0016298 molecular function lipase activity Catalysis of the hydrolysis of a lipid or phospholipid. (more detail) 121 NA Homo sapiens
MEX002097
Genes associated with Kinase Inhibitor 1092351 67 1 Genes associated with Kinase Inhibitor 1092351-67-1, curated by the Drug Signature Database (DSigDB) (more detail) 120 25990557 Homo sapiens
FEX002891
StemCell Bhattacharya05 2471genes Supplementary Table 1Sb. Over expression of genes ( (more detail) 1986 16207381 Homo sapiens
MAX002337
Genes constituting the BRCA1 PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA1 [GeneID=672] across a compendium of normal tissues. Many cancer-associated genes remain to be identified to clarify the underlying molecular mechanisms (more detail) 1554 NA Homo sapiens
TAX026199
GO:0048519 biological process negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. (more detail) 4829 NA Homo sapiens
MEX001279
Genes associated with Kinase Inhibitor AGN PC 04XSRZ Genes associated with Kinase Inhibitor AGN-PC-04XSRZ, curated by the Drug Signature Database (DSigDB (more detail) 119 25990557 Homo sapiens
TAX020967
GO:0031399 biological process regulation of protein modification process Any process that modulates the frequency, rate or extent of the covalent alteration of one or more a (more detail) 1744 NA Homo sapiens
MEX002317
Genes associated with Kinase Inhibitor CGP74514A Genes associated with Kinase Inhibitor CGP74514A, curated by the Drug Signature Database (DSigDB). (more detail) 122 25990557 Homo sapiens
TAX000573
Genes annotated by the GO term GO:0006508. The hydrolysis of a peptide bond or bonds within a protein. (more detail) 184 NA Homo sapiens
FEX001762
Liver Tzur09 1908genes Table S5. Differentially-expressed genes throughout development; Multiple genes were significantly ( (more detail) 1410 19841744 Homo sapiens
MEX002416
Genes associated with Kinase Inhibitor Dabrafenib Genes associated with Kinase Inhibitor Dabrafenib, curated by the Drug Signature Database (DSigDB). (more detail) 121 25990557 Homo sapiens
MEX001869
Genes associated with Kinase Inhibitor Dabrafenib Genes associated with Kinase Inhibitor Dabrafenib, curated by the Drug Signature Database (DSigDB). (more detail) 121 25990557 Homo sapiens
MEX001460
Genes associated with Kinase Inhibitor CP 466722 Genes associated with Kinase Inhibitor CP-466722, curated by the Drug Signature Database (DSigDB). (more detail) 117 25990557 Homo sapiens
TAX015213
GO:0004540 molecular function ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. (more detail) 117 NA Homo sapiens
WIG000921
Genes involved in Immune System (more detail) 893 NA Homo sapiens
MOX003704
Genes associated with Computational Drug Signature atrazine Genes associated with Computational Drug Signature atrazine, curated by the Drug Signature Database (more detail) 2827 25990557 Homo sapiens
MEX001667
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 116 25990557 Homo sapiens
TAX019130
GO:0016616 molecular function oxidoreductase activity, acting on the CH OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or el (more detail) 116 NA Homo sapiens
FEX012386
The genes express in medium or high level in at least 95% samples in colorectal cancer. Staining profiles for proteins in human tumor tissue based on immunohistochemisty using tissue micro (more detail) 3023 28818916 Homo sapiens
TAX001090
Genes annotated by the GO term GO:0005524. Interacting selectively with ATP, adenosine 5' triphosphate, a universally important coenzyme and enzyme regulator. (more detail) 151 NA Homo sapiens
TAX031034
GO:0098588 cellular component bounding membrane of organelle The lipid bilayer that forms the outer-most layer of an organelle. (more detail) 1871 NA Homo sapiens
MOX000847
Genes associated with Computational Drug Signature Arsenenous acid Genes associated with Computational Drug Signature Arsenenous acid, curated by the Drug Signature Da (more detail) 1244 25990557 Homo sapiens
TAX017797
GO:0009893 biological process positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 3295 NA Homo sapiens
TAX000067
Genes annotated by the GO term GO:0005975. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. (more detail) 176 NA Homo sapiens
MEX002025
Genes associated with Kinase Inhibitor PD173955 Genes associated with Kinase Inhibitor PD173955, curated by the Drug Signature Database (DSigDB). (more detail) 114 25990557 Homo sapiens
FEX012538
The normalized gene expressions no less than 30 in the tissue of skeletal muscle from the Gene Tissue Expression project. Transcript expression levels summarized per gene in 36 tissues based on RNA-seq. The tab-separated f (more detail) 2206 25613900 Homo sapiens
TAX017517
GO:0009116 biological process nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-rib (more detail) 121 NA Homo sapiens
TAX029166
GO:0070887 biological process cellular response to chemical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 1531 NA Homo sapiens
TAX017542
GO:0009144 biological process purine nucleoside triphosphate metabolic process The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting (more detail) 146 NA Homo sapiens
TAX015776
GO:0005506 molecular function iron ion binding Interacting selectively and non-covalently with iron (Fe) ions. (more detail) 151 NA Homo sapiens
TAX015036
GO:0004222 molecular function metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 113 NA Homo sapiens
TAX023938
GO:0042626 molecular function ATPase activity, coupled to transmembrane movement of substances Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a (more detail) 113 NA Homo sapiens
MOX004120
Genes associated with Computational Drug Signature formaldehyde Genes associated with Computational Drug Signature formaldehyde, curated by the Drug Signature Datab (more detail) 3006 25990557 Homo sapiens
TAX017524
GO:0009126 biological process purine nucleoside monophosphate metabolic process The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting (more detail) 145 NA Homo sapiens
TAX017591
GO:0009199 biological process ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting o (more detail) 145 NA Homo sapiens
MAX000195
Genes down regulated in brain from patients with Alzheimer's disease. The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis because of the (more detail) 1158 NA Homo sapiens
TAX016494
GO:0006643 biological process membrane lipid metabolic process The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with (more detail) 190 NA Homo sapiens
MEX000921
Genes associated with Approved Drug dasatinib Genes associated with Approved Drug dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 144 25990557 Homo sapiens
TAX017564
GO:0009167 biological process purine ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consis (more detail) 144 NA Homo sapiens
MEX000804
Genes associated with Approved Drug sorafenib Genes associated with Approved Drug sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 115 25990557 Homo sapiens
TAX017146
GO:0008238 molecular function exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus (more detail) 111 NA Homo sapiens
TAX013278
GO:0000151 cellular component ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase acti (more detail) 304 NA Homo sapiens
TAX001152
Genes annotated by the GO term GO:0004175. Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub subclasses EC:3.4.21 99. They are classfied according to the presence of essential catalytic residues or ions at their active sites. (more detail) 114 NA Homo sapiens
TAX017479
GO:0009063 biological process cellular amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids contain (more detail) 114 NA Homo sapiens
TAX016256
GO:0006325 biological process chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of (more detail) 607 NA Homo sapiens
IEI014567
Protein protein interactors of human gene UBE2D2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2D2 (SwissProt ID (more detail) 211 17535438 Homo sapiens
TAX020341
GO:0030163 biological process protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of th (more detail) 368 NA Homo sapiens
IEI013211
Protein protein interactors of human gene SUMO2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SUMO2 (SwissProt ID= (more detail) 1645 17535438 Homo sapiens
TAX024656
GO:0044272 biological process sulfur compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, suc (more detail) 175 NA Homo sapiens
MEX003284
Genes associated with Perturbagen Signature glibenclamide Genes associated with Perturbagen Signature glibenclamide, curated by the Drug Signature Database (D (more detail) 1269 25990557 Homo sapiens
MEX001267
Genes associated with Kinase Inhibitor OTSSP167 Genes associated with Kinase Inhibitor OTSSP167, curated by the Drug Signature Database (DSigDB). (more detail) 108 25990557 Homo sapiens
MOX002245
Genes associated with Computational Drug Signature resveratrol Genes associated with Computational Drug Signature resveratrol, curated by the Drug Signature Databa (more detail) 1552 25990557 Homo sapiens
FAX000286
Genes with promoter regions [ 2kb,2kb] around transcription start site containing the motif GGGCGGR which matches annotation for SP1: Sp1 transcription factor Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGGCGGR (more detail) 2720 NA Homo sapiens
TAX022590
GO:0034655 biological process nucleobase containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleoti (more detail) 394 NA Homo sapiens
TAX001085
Genes annotated by the GO term GO:0016887. Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. (more detail) 111 NA Homo sapiens
TAX032077
GO:1901292 biological process nucleoside phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. (more detail) 107 NA Homo sapiens
TAX000054
Genes annotated by the GO term GO:0009058. The energy requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes. (more detail) 453 NA Homo sapiens
TAX019871
GO:0019899 molecular function enzyme binding Interacting selectively and non-covalently with any enzyme. (more detail) 2186 NA Homo sapiens
MEX000922
Genes associated with Approved Drug vandetanib Genes associated with Approved Drug vandetanib, curated by the Drug Signature Database (DSigDB). (more detail) 114 25990557 Homo sapiens
MAX001958
Mitochondrial genes DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 413 NA Homo sapiens
IEI008418
Protein protein interactors of human gene MYC from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MYC (SwissProt ID=P0 (more detail) 993 17535438 Homo sapiens
TAX017597
GO:0009205 biological process purine ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consist (more detail) 139 NA Homo sapiens
FEX012387
The genes express in medium or high level in at least 95% samples in head and neck cancer. Staining profiles for proteins in human tumor tissue based on immunohistochemisty using tissue micro (more detail) 3176 28818916 Homo sapiens
TAX024027
GO:0042802 molecular function identical protein binding Interacting selectively and non-covalently with an identical protein or proteins. (more detail) 1636 NA Homo sapiens
TAX017471
GO:0009055 molecular function electron transfer activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport (more detail) 106 NA Homo sapiens
TAX000449
Genes annotated by the GO term GO:0006082. The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. (more detail) 173 NA Homo sapiens
MEX002436
Genes associated with Perturbagen Signature 0175029 0000 Genes associated with Perturbagen Signature 0175029-0000, curated by the Drug Signature Database (DS (more detail) 3253 25990557 Homo sapiens
MEX003494
Genes associated with Perturbagen Signature lobeline Genes associated with Perturbagen Signature lobeline, curated by the Drug Signature Database (DSigDB (more detail) 1442 25990557 Homo sapiens
TAX026894
GO:0051247 biological process positive regulation of protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 1570 NA Homo sapiens
MEX003462
Genes associated with Perturbagen Signature latamoxef Genes associated with Perturbagen Signature latamoxef, curated by the Drug Signature Database (DSigD (more detail) 1497 25990557 Homo sapiens
IEI014566
Protein protein interactors of human gene UBE2D1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2D1 (SwissProt ID (more detail) 247 17535438 Homo sapiens
WAG000604
Glycan structures biosynthesis 1 (more detail) 104 NA Homo sapiens
TAX031707
GO:0140101 molecular function catalytic activity, acting on a tRNA Catalytic activity that acts to modify a tRNA. (more detail) 104 NA Homo sapiens
TAX000069
Genes annotated by the GO term GO:0019752. The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO ). (more detail) 171 NA Homo sapiens
TAX029047
GO:0070646 biological process protein modification by small protein removal A protein modification process in which one or more covalently attached groups of a small protein, s (more detail) 285 NA Homo sapiens
TAX001426
Genes annotated by the GO term GO:0016757. Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). (more detail) 111 NA Homo sapiens
TAX001312
Genes annotated by the GO term GO:0016791. Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. (more detail) 107 NA Homo sapiens
MEX001316
Genes associated with Kinase Inhibitor 405169 16 6 Genes associated with Kinase Inhibitor 405169-16-6, curated by the Drug Signature Database (DSigDB). (more detail) 103 25990557 Homo sapiens
TAX019147
GO:0016651 molecular function oxidoreductase activity, acting on NAD(P)H Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or el (more detail) 103 NA Homo sapiens
TAX024641
GO:0044242 biological process cellular lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individu (more detail) 170 NA Homo sapiens
MOX001842
Genes associated with Computational Drug Signature ( ) Epigallocatechin gallate Genes associated with Computational Drug Signature (-)-Epigallocatechin gallate, curated by the Drug (more detail) 2014 25990557 Homo sapiens
TAX015346
GO:0004725 molecular function protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. (more detail) 102 NA Homo sapiens
TAX022824
GO:0035335 biological process peptidyl tyrosine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. (more detail) 102 NA Homo sapiens
TAX021423
GO:0032270 biological process positive regulation of cellular protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 1481 NA Homo sapiens
TAX023987
GO:0042737 biological process drug catabolic process The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the di (more detail) 115 NA Homo sapiens
TAX030035
GO:0072524 biological process pyridine containing compound metabolic process The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that (more detail) 115 NA Homo sapiens
TAX019105
GO:0016579 biological process protein deubiquitination The removal of one or more ubiquitin groups from a protein. (more detail) 269 NA Homo sapiens
TAX017563
GO:0009166 biological process nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that i (more detail) 101 NA Homo sapiens
MEX001932
Genes associated with Kinase Inhibitor Crizotinib Genes associated with Kinase Inhibitor Crizotinib, curated by the Drug Signature Database (DSigDB). (more detail) 101 25990557 Homo sapiens
TAX024650
GO:0044262 biological process cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds bas (more detail) 145 NA Homo sapiens
TAX016560
GO:0006733 biological process oxidoreduction coenzyme metabolic process The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme (more detail) 125 NA Homo sapiens
WIG000975
Genes involved in Metabolism of amino acids and derivatives (more detail) 192 NA Homo sapiens
IEI014568
Protein protein interactors of human gene UBE2D3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2D3 (SwissProt ID (more detail) 202 17535438 Homo sapiens
TAX020925
GO:0031325 biological process positive regulation of cellular metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 3034 NA Homo sapiens
MEX002384
Genes associated with Kinase Inhibitor A 443654 Genes associated with Kinase Inhibitor A-443654, curated by the Drug Signature Database (DSigDB). (more detail) 104 25990557 Homo sapiens
TAX026849
GO:0051174 biological process regulation of phosphorus metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 1662 NA Homo sapiens
MEX002187
Genes associated with Kinase Inhibitor Antibiotic K 252a Genes associated with Kinase Inhibitor Antibiotic K 252a, curated by the Drug Signature Database (DS (more detail) 100 25990557 Homo sapiens
MEX001715
Genes associated with Kinase Inhibitor PHA 767491 Genes associated with Kinase Inhibitor PHA-767491, curated by the Drug Signature Database (DSigDB). (more detail) 100 25990557 Homo sapiens
WIG000678
Genes involved in Adaptive Immune System (more detail) 512 NA Homo sapiens
MOX004073
Genes associated with Computational Drug Signature ETHYL METHANESULFONATE Genes associated with Computational Drug Signature ETHYL METHANESULFONATE, curated by the Drug Signa (more detail) 2191 25990557 Homo sapiens
TAX019645
GO:0019220 biological process regulation of phosphate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 1660 NA Homo sapiens
TAX019326
GO:0016999 biological process antibiotic metabolic process The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from (more detail) 121 NA Homo sapiens
MEX002223
Genes associated with Kinase Inhibitor CHEMBL1908395 Genes associated with Kinase Inhibitor CHEMBL1908395, curated by the Drug Signature Database (DSigDB (more detail) 99 25990557 Homo sapiens
TAX013767
GO:0001676 biological process long chain fatty acid metabolic process The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a f (more detail) 106 NA Homo sapiens
TAX016060
GO:0005996 biological process monosaccharide metabolic process The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are (more detail) 196 NA Homo sapiens
MAX001341
Genes involved in DNA repair, compiled manually by the authors. We have identified a gene-profile signature for human primary malignant melanoma associated with met (more detail) 223 NA Homo sapiens
TAX026232
GO:0048584 biological process positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to (more detail) 2173 NA Homo sapiens
TAX015217
GO:0004553 molecular function hydrolase activity, hydrolyzing O glycosyl compounds Catalysis of the hydrolysis of any O-glycosyl bond. (more detail) 98 NA Homo sapiens
WAG000395
Pyrimidine metabolism (more detail) 98 NA Homo sapiens
TAX028695
GO:0070035 molecular function purine NTP dependent helicase activity Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DN (more detail) 98 NA Homo sapiens
TAX017021
GO:0008026 molecular function ATP dependent helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix (more detail) 98 NA Homo sapiens
TAX019001
GO:0016407 molecular function acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule. (more detail) 98 NA Homo sapiens
FEX012498
The normalized gene expressions no less than 30 in the tissue of skeletal muscle from the Human Protein Atlas. Transcript expression levels summarized per gene in 37 tissues based on RNA-seq. The tab-separated f (more detail) 2201 25613900 Homo sapiens
TAX032020
GO:1901136 biological process carbohydrate derivative catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. (more detail) 176 NA Homo sapiens
TAX019004
GO:0016410 molecular function N acyltransferase activity Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. (more detail) 97 NA Homo sapiens
TAX015272
GO:0004620 molecular function phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid. (more detail) 97 NA Homo sapiens
TAX022255
GO:0033875 biological process ribonucleoside bisphosphate metabolic process The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting o (more detail) 124 NA Homo sapiens
TAX022249
GO:0033865 biological process nucleoside bisphosphate metabolic process The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a (more detail) 124 NA Homo sapiens
TAX022276
GO:0034032 biological process purine nucleoside bisphosphate metabolic process The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consistin (more detail) 124 NA Homo sapiens
TAX026203
GO:0048523 biological process negative regulation of cellular process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, an (more detail) 4334 NA Homo sapiens
TAX018605
GO:0015399 molecular function primary active transmembrane transporter activity Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentra (more detail) 121 NA Homo sapiens
TAX018606
GO:0015405 molecular function P P bond hydrolysis driven transmembrane transporter activity Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate (more detail) 121 NA Homo sapiens
FEX002505
Breast Nagaraja10 3054genes Supplementary Table: down in clear cell (1709) (more detail) 2170 20081105 Homo sapiens
FEX012440
The normalized gene expressions no less than 30 in the tissue of kidney. Consensus transcript expression levels summarized per gene in 62 tissues based on transcriptomics da (more detail) 1774 25613900 Homo sapiens
TAX015176
GO:0004497 molecular function monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction o (more detail) 96 NA Homo sapiens
TAX025760
GO:0046834 biological process lipid phosphorylation The process of introducing one or more phosphate groups into a lipid, any member of a group of subst (more detail) 112 NA Homo sapiens
TAX016302
GO:0006399 biological process tRNA metabolic process The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA mo (more detail) 159 NA Homo sapiens
TAX023777
GO:0042325 biological process regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into a mole (more detail) 1465 NA Homo sapiens
TAX017100
GO:0008170 molecular function N methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. (more detail) 95 NA Homo sapiens
MEX001872
Genes associated with Kinase Inhibitor Cdk1/2 Inhibitor III Genes associated with Kinase Inhibitor Cdk1/2 Inhibitor III, curated by the Drug Signature Database (more detail) 95 25990557 Homo sapiens
TAX024237
GO:0043228 cellular component non membrane bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. (more detail) 2397 NA Homo sapiens
TAX025603
GO:0046496 biological process nicotinamide nucleotide metabolic process The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains (more detail) 108 NA Homo sapiens
TAX019691
GO:0019362 biological process pyridine nucleotide metabolic process The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a (more detail) 108 NA Homo sapiens
WIG000698
Genes involved in Antigen processing: Ubiquitination & Proteasome degradation (more detail) 199 NA Homo sapiens
FEX002501
Ovarian Li09 2322genes cisplatinresistance Supplementary Table 3- Differentially expressed genes in isogenic cisplatin-resistant (Round5) vs. c (more detail) 1691 19505326 Homo sapiens
TAX018842
GO:0016052 biological process carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of o (more detail) 107 NA Homo sapiens
MEX001047
Genes associated with Approved Drug axitinib Genes associated with Approved Drug axitinib, curated by the Drug Signature Database (DSigDB). (more detail) 104 25990557 Homo sapiens
FEX000640
Breast Creighton08 2154genes Supplementary Data File 1 (more detail) 1610 18757322 Homo sapiens
FEX012060
hsa miR 26b 5p HITS-CLIP, Functional MTI (Weak) (more detail) 1740 NA Homo sapiens
TAX017519
GO:0009119 biological process ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or py (more detail) 97 NA Homo sapiens
TAX032181
GO:1901606 biological process alpha amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. (more detail) 97 NA Homo sapiens
TAX001086
Genes annotated by the GO term GO:0042623. Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane. (more detail) 93 NA Homo sapiens
TAX020240
GO:0023051 biological process regulation of signaling Any process that modulates the frequency, rate or extent of a signaling process. (more detail) 3402 NA Homo sapiens
TAX024241
GO:0043232 cellular component intracellular non membrane bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane (more detail) 2386 NA Homo sapiens
TAX032546
GO:1902531 biological process regulation of intracellular signal transduction Any process that modulates the frequency, rate or extent of intracellular signal transduction. (more detail) 1788 NA Homo sapiens
MEX001763
Genes associated with Kinase Inhibitor PKR Inhibitor Genes associated with Kinase Inhibitor PKR Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 92 25990557 Homo sapiens
WIG001095
Genes involved in Post translational protein modification (more detail) 178 NA Homo sapiens
FEX000689
Breast Parker09 1918genes IntrinsicGenes Compilation Supplementary Table 5. Compilation of Microarray Intrinsic Genes and PCR Genes (more detail) 1586 19204204 Homo sapiens
TAX016712
GO:0006979 biological process response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 341 NA Homo sapiens
WIG000604
Pyrimidine metabolism (more detail) 95 NA Homo sapiens
TAX001174
Genes annotated by the GO term GO:0003924. Catalysis of the reaction: GTP + H2O = GDP + phosphate. (more detail) 95 NA Homo sapiens
TAX026873
GO:0051213 molecular function dioxygenase activity Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule (more detail) 91 NA Homo sapiens
TAX017992
GO:0010604 biological process positive regulation of macromolecule metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 3056 NA Homo sapiens
TAX017168
GO:0008276 molecular function protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein. (more detail) 90 NA Homo sapiens
MEX002413
Genes associated with Kinase Inhibitor Ponatinib Genes associated with Kinase Inhibitor Ponatinib, curated by the Drug Signature Database (DSigDB). (more detail) 90 25990557 Homo sapiens
TAX025583
GO:0046467 biological process membrane lipid biosynthetic process The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found i (more detail) 119 NA Homo sapiens
TAX021604
GO:0032502 biological process developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anat (more detail) 4753 NA Homo sapiens
FEX012385
The genes express in medium or high level in at least 95% samples in carcinoid. Staining profiles for proteins in human tumor tissue based on immunohistochemisty using tissue micro (more detail) 2147 28818916 Homo sapiens
TAX018027
GO:0010646 biological process regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication i (more detail) 3375 NA Homo sapiens
WAG000382
Aminoacyl tRNA biosynthesis (more detail) 89 NA Homo sapiens
TAX017050
GO:0008081 molecular function phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group (more detail) 89 NA Homo sapiens
WIG000638
Ubiquitin mediated proteolysis Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions (more detail) 130 NA Homo sapiens
FEX003033
StemCell Nuytten08 2072genes Table S2 List of all genes with a significantly changed expression level after the knockdown of EZH2 (more detail) 1664 17724462 Homo sapiens
TAX030717
GO:0097164 biological process ammonium ion metabolic process The chemical reactions and pathways involving the ammonium ion. (more detail) 178 NA Homo sapiens
MEX001740
Genes associated with Kinase Inhibitor A 770041 Genes associated with Kinase Inhibitor A-770041, curated by the Drug Signature Database (DSigDB). (more detail) 92 25990557 Homo sapiens
TAX000078
Genes annotated by the GO term GO:0044262. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. (more detail) 122 NA Homo sapiens
TAX026848
GO:0051173 biological process positive regulation of nitrogen compound metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and (more detail) 2921 NA Homo sapiens
TAX017820
GO:0009966 biological process regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. (more detail) 3036 NA Homo sapiens
TAX016507
GO:0006661 biological process phosphatidylinositol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycopho (more detail) 131 NA Homo sapiens
TAX017522
GO:0009124 biological process nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a comp (more detail) 109 NA Homo sapiens
TAX000427
Genes annotated by the GO term GO:0006807. The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. (more detail) 148 NA Homo sapiens
MEX002312
Genes associated with Kinase Inhibitor Tozasertib Genes associated with Kinase Inhibitor Tozasertib, curated by the Drug Signature Database (DSigDB). (more detail) 87 25990557 Homo sapiens
TAX015034
GO:0004197 molecular function cysteine type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 87 NA Homo sapiens
TAX019232
GO:0016811 molecular function hydrolase activity, acting on carbon nitrogen (but not peptide) bonds, in linear amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. (more detail) 87 NA Homo sapiens
TAX030549
GO:0090501 biological process RNA phosphodiester bond hydrolysis The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by h (more detail) 154 NA Homo sapiens
WIG001528
GPCR Pathway GPCR Pathway (more detail) 214 NA Homo sapiens
TAX017058
GO:0008094 molecular function DNA dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of singl (more detail) 86 NA Homo sapiens
MEX001604
Genes associated with Kinase Inhibitor BRD K29385665 001 01 1 Genes associated with Kinase Inhibitor BRD-K29385665-001-01-1, curated by the Drug Signature Databas (more detail) 86 25990557 Homo sapiens
TAX014210
GO:0002376 biological process immune system process Any process involved in the development or functioning of the immune system, an organismal system fo (more detail) 2289 NA Homo sapiens
MOX000607
Genes associated with Computational Drug Signature trichostatin A Genes associated with Computational Drug Signature trichostatin A, curated by the Drug Signature Dat (more detail) 3377 25990557 Homo sapiens
MEX001926
Genes associated with Kinase Inhibitor AGN PC 045KSD Genes associated with Kinase Inhibitor AGN-PC-045KSD, curated by the Drug Signature Database (DSigDB (more detail) 85 25990557 Homo sapiens
WAG000988
Ubiquitin mediated proteolysis Protein ubiquitition plays an important role in eukaryotic cellular processes. It mainly functions a (more detail) 121 NA Homo sapiens
TAX017939
GO:0010498 biological process proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 279 NA Homo sapiens
TAX025771
GO:0046854 biological process phosphatidylinositol phosphorylation The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophos (more detail) 100 NA Homo sapiens
WIG000763
Genes involved in Class I MHC mediated antigen processing & presentation (more detail) 237 NA Homo sapiens
MEX002400
Genes associated with Kinase Inhibitor Palbociclib Genes associated with Kinase Inhibitor Palbociclib, curated by the Drug Signature Database (DSigDB). (more detail) 83 25990557 Homo sapiens
MEX001840
Genes associated with Kinase Inhibitor SB 218078 Genes associated with Kinase Inhibitor SB 218078, curated by the Drug Signature Database (DSigDB). (more detail) 83 25990557 Homo sapiens
MEX001819
Genes associated with Kinase Inhibitor Palbociclib Genes associated with Kinase Inhibitor Palbociclib, curated by the Drug Signature Database (DSigDB). (more detail) 83 25990557 Homo sapiens
FEX012381
The genes express in medium or high level in at least 95% samples in prostate cancer. Staining profiles for proteins in human tumor tissue based on immunohistochemisty using tissue micro (more detail) 2113 28818916 Homo sapiens
TAX020229
GO:0023014 biological process signal transduction by protein phosphorylation A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to (more detail) 319 NA Homo sapiens
TAX016720
GO:0006996 biological process organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of co (more detail) 2140 NA Homo sapiens
TAX019496
GO:0018210 biological process peptidyl threonine modification The modification of peptidyl-threonine. (more detail) 86 NA Homo sapiens
IEI009617
Protein protein interactors of human gene PCNA from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PCNA (SwissProt ID=P (more detail) 298 17535438 Homo sapiens
MEX002344
Genes associated with Kinase Inhibitor staurosporine Genes associated with Kinase Inhibitor staurosporine, curated by the Drug Signature Database (DSigDB (more detail) 82 25990557 Homo sapiens
TAX015204
GO:0004527 molecular function exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues f (more detail) 82 NA Homo sapiens
WIG000976
Genes involved in Metabolism of carbohydrates (more detail) 235 NA Homo sapiens
MEX002399
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 81 25990557 Homo sapiens
MEX002053
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 81 25990557 Homo sapiens
TAX014790
GO:0003777 molecular function microtubule motor activity Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (u (more detail) 81 NA Homo sapiens
TAX017049
GO:0008080 molecular function N acetyltransferase activity Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. (more detail) 81 NA Homo sapiens
TAX028544
GO:0061695 cellular component transferase complex, transferring phosphorus containing groups A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one (more detail) 190 NA Homo sapiens
TAX001227
Genes annotated by the GO term GO:0016874. Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. (more detail) 84 NA Homo sapiens
TAX027095
GO:0051604 biological process protein maturation Any process leading to the attainment of the full functional capacity of a protein. (more detail) 204 NA Homo sapiens
MEX001982
Genes associated with Kinase Inhibitor Aurora A Inhibitor I Genes associated with Kinase Inhibitor Aurora A Inhibitor I, curated by the Drug Signature Database (more detail) 80 25990557 Homo sapiens
MEX001415
Genes associated with Kinase Inhibitor Kinome 3629 Genes associated with Kinase Inhibitor Kinome_3629, curated by the Drug Signature Database (DSigDB). (more detail) 80 25990557 Homo sapiens
TAX016532
GO:0006690 biological process icosanoid metabolic process The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatt (more detail) 101 NA Homo sapiens
TAX016511
GO:0006665 biological process sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the (more detail) 144 NA Homo sapiens
TAX029958
GO:0072329 biological process monocarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic (more detail) 106 NA Homo sapiens
WAG000599
Glycolysis / Gluconeogenesis Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (e (more detail) 79 NA Homo sapiens
MOX013004
Genes associated with Computational Drug Signature hesperadin Genes associated with Computational Drug Signature hesperadin, curated by the Drug Signature Databas (more detail) 79 25990557 Homo sapiens
TAX022690
GO:0035004 molecular function phosphatidylinositol 3 kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. (more detail) 79 NA Homo sapiens
TAX015433
GO:0004843 molecular function thiol dependent ubiquitin specific protease activity Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ub (more detail) 79 NA Homo sapiens
TAX016486
GO:0006633 biological process fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic (more detail) 100 NA Homo sapiens
TAX017554
GO:0009156 biological process ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a (more detail) 100 NA Homo sapiens
FEX012439
The normalized gene expressions no less than 30 in the tissue of heart muscle. Consensus transcript expression levels summarized per gene in 62 tissues based on transcriptomics da (more detail) 2033 25613900 Homo sapiens
TAX000022
Genes annotated by the GO term GO:0009308. The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. (more detail) 134 NA Homo sapiens
TAX017133
GO:0008213 biological process protein alkylation The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an (more detail) 123 NA Homo sapiens
TAX016361
GO:0006479 biological process protein methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by th (more detail) 123 NA Homo sapiens
TAX030038
GO:0072527 biological process pyrimidine containing compound metabolic process The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound th (more detail) 94 NA Homo sapiens
TAX022139
GO:0033559 biological process unsaturated fatty acid metabolic process The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing o (more detail) 94 NA Homo sapiens
TAX017705
GO:0009451 biological process RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule (more detail) 142 NA Homo sapiens
MEX001742
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 78 25990557 Homo sapiens
FEX000559
Breast Kreike07 3712genes Basal mets Table S5 Results of the supervised analysis using SAM software of 71 triple-negative tumors comparin (more detail) 2302 17910759 Homo sapiens
TAX023843
GO:0042445 biological process hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted b (more detail) 184 NA Homo sapiens
TAX017530
GO:0009132 biological process nucleoside diphosphate metabolic process The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a n (more detail) 81 NA Homo sapiens
TAX025404
GO:0046034 biological process ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important c (more detail) 108 NA Homo sapiens
TAX024191
GO:0043161 biological process proteasome mediated ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 257 NA Homo sapiens
TAX026814
GO:0051128 biological process regulation of cellular component organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arr (more detail) 2353 NA Homo sapiens
TAX001148
Genes annotated by the GO term GO:0009055. Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. (more detail) 77 NA Homo sapiens
TAX019627
GO:0019199 molecular function transmembrane receptor protein kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 77 NA Homo sapiens
TAX019795
GO:0019751 biological process polyol metabolic process The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxy (more detail) 100 NA Homo sapiens
TAX025802
GO:0046906 molecular function tetrapyrrole binding Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole n (more detail) 138 NA Homo sapiens
TAX032190
GO:1901617 biological process organic hydroxy compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic hydroxy compound. (more detail) 160 NA Homo sapiens
WAG001432
Oxidative phosphorylation (more detail) 89 NA Homo sapiens
PEX002586
Pkinase Tyr: Protein tyrosine kinase (more detail) 76 NA Homo sapiens
TAX018841
GO:0016051 biological process carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of o (more detail) 120 NA Homo sapiens
TAX019462
GO:0018107 biological process peptidyl threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. (more detail) 79 NA Homo sapiens
MEX000761
Genes associated with Approved Drug gefitinib Genes associated with Approved Drug gefitinib, curated by the Drug Signature Database (DSigDB). (more detail) 88 25990557 Homo sapiens
FOX000722
Genes in the cancer module 43 (more detail) 96 NA Homo sapiens
TAX019248
GO:0016835 molecular function carbon oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond. (more detail) 75 NA Homo sapiens
MEX001238
Genes associated with Kinase Inhibitor A 674563 Genes associated with Kinase Inhibitor A-674563, curated by the Drug Signature Database (DSigDB). (more detail) 75 25990557 Homo sapiens
TAX019917
GO:0020037 molecular function heme binding Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (more detail) 130 NA Homo sapiens
TAX016603
GO:0006805 biological process xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living or (more detail) 110 NA Homo sapiens
TAX016489
GO:0006637 biological process acyl CoA metabolic process The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the su (more detail) 90 NA Homo sapiens
TAX022852
GO:0035383 biological process thioester metabolic process The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' i (more detail) 90 NA Homo sapiens
TAX001309
Genes annotated by the GO term GO:0004721. Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. (more detail) 78 NA Homo sapiens
WAG000990
Glycerophospholipid metabolism (more detail) 74 NA Homo sapiens
FEX012435
The normalized gene expressions no less than 30 in the tissue of cerebral cortex. Consensus transcript expression levels summarized per gene in 62 tissues based on transcriptomics da (more detail) 2679 25613900 Homo sapiens
TAX017124
GO:0008202 biological process steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophe (more detail) 247 NA Homo sapiens
TAX024432
GO:0043543 biological process protein acylation The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to (more detail) 166 NA Homo sapiens
WIG001490
Estrogen Pathway Estrogen Pathway (more detail) 113 NA Homo sapiens
TAX001428
Genes annotated by the GO term GO:0016758. Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). (more detail) 80 NA Homo sapiens
WAG000995
Starch and sucrose metabolism (more detail) 73 NA Homo sapiens
FEX003128
StemCell Majeti09 3024genes Dataset (ST3). 3 005 differentially expressed genes with 1 451 genes being up-regulated and 1 554 ge (more detail) 2552 19218430 Homo sapiens
TAX032110
GO:1901362 biological process organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic cyclic compound. (more detail) 3181 NA Homo sapiens
FOX000698
Genes in the cancer module 40 (more detail) 82 NA Homo sapiens
WIG000506
Drug metabolism cytochrome P450 (more detail) 72 NA Homo sapiens
TAX016809
GO:0007165 biological process signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a (more detail) 4709 NA Homo sapiens
TAX026496
GO:0050660 molecular function flavin adenine dinucleotide binding Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or th (more detail) 75 NA Homo sapiens
TAX028676
GO:0065009 biological process regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biolo (more detail) 3093 NA Homo sapiens
PEX001521
Ras: Ras family Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, (more detail) 71 NA Homo sapiens
TAX019213
GO:0016782 molecular function transferase activity, transferring sulfur containing groups Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (accepto (more detail) 71 NA Homo sapiens
TAX015344
GO:0004722 molecular function protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein (more detail) 71 NA Homo sapiens
TAX027456
GO:0052813 molecular function phosphatidylinositol bisphosphate kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol (more detail) 71 NA Homo sapiens
TAX034189
GO:1990204 cellular component oxidoreductase complex Any protein complex that possesses oxidoreductase activity. (more detail) 101 NA Homo sapiens
TAX026593
GO:0050790 biological process regulation of catalytic activity Any process that modulates the activity of an enzyme. (more detail) 2233 NA Homo sapiens
FEX012572
The normalized gene expressions no less than 30 in the tissue of cerebral cortex from the Function Annotation of the Mammalian Genome project. Transcript expression levels summarized per gene in 60 tissues based on CAGE data. The tab-separated (more detail) 2294 25613900 Homo sapiens
WIG000561
Metabolism of xenobiotics by cytochrome P450 (more detail) 70 NA Homo sapiens
IEI014585
Protein protein interactors of human gene UBE2N from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2N (SwissProt ID= (more detail) 191 17535438 Homo sapiens
TAX017540
GO:0009142 biological process nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compo (more detail) 92 NA Homo sapiens
WAG000810
Drug metabolism cytochrome P450 (more detail) 69 NA Homo sapiens
TAX019675
GO:0019318 biological process hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbo (more detail) 153 NA Homo sapiens
TAX020329
GO:0030148 biological process sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of l (more detail) 84 NA Homo sapiens
TAX000322
Genes annotated by the GO term GO:0009057. The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates. (more detail) 133 NA Homo sapiens
TAX017391
GO:0008652 biological process cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids contain (more detail) 81 NA Homo sapiens
TAX023750
GO:0042278 biological process purine nucleoside metabolic process The chemical reactions and pathways involving one of a family of organic molecules consisting of a p (more detail) 72 NA Homo sapiens
TAX030477
GO:0090304 biological process nucleic acid metabolic process Any cellular metabolic process involving nucleic acids. (more detail) 3889 NA Homo sapiens
TAX017505
GO:0009100 biological process glycoprotein metabolic process The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bo (more detail) 116 NA Homo sapiens
WAG001215
Metabolism of xenobiotics by cytochrome P450 (more detail) 68 NA Homo sapiens
TAX014777
GO:0003724 molecular function RNA helicase activity Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. (more detail) 68 NA Homo sapiens
TAX025818
GO:0046934 molecular function phosphatidylinositol 4,5 bisphosphate 3 kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl- (more detail) 68 NA Homo sapiens
TAX017111
GO:0008186 molecular function RNA dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, (more detail) 68 NA Homo sapiens
WIG001649
Ras Pathway Ras Pathway (more detail) 146 NA Homo sapiens
TAX017023
GO:0008033 biological process tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an ami (more detail) 111 NA Homo sapiens
FOX000503
Genes in the cancer module 172 (more detail) 95 NA Homo sapiens
TAX024492
GO:0043648 biological process dicarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two ca (more detail) 95 NA Homo sapiens
TAX019047
GO:0016485 biological process protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. (more detail) 147 NA Homo sapiens
TAX019201
GO:0016765 molecular function transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to an (more detail) 67 NA Homo sapiens
TAX014910
GO:0004004 molecular function ATP dependent RNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA (more detail) 67 NA Homo sapiens
TAX001236
Genes annotated by the GO term GO:0016829. Catalysis of the cleavage of C C, C O, C N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. (more detail) 67 NA Homo sapiens
TAX032978
GO:1903509 biological process liposaccharide metabolic process The chemical reactions and pathways involving liposaccharide. (more detail) 101 NA Homo sapiens
TAX030036
GO:0072525 biological process pyridine containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i. (more detail) 73 NA Homo sapiens
TAX022372
GO:0034212 molecular function peptide N acetyltransferase activity Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reac (more detail) 66 NA Homo sapiens
TAX015199
GO:0004521 molecular function endoribonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. (more detail) 66 NA Homo sapiens
TAX017525
GO:0009127 biological process purine nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a (more detail) 86 NA Homo sapiens
TAX017565
GO:0009168 biological process purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphat (more detail) 86 NA Homo sapiens
TAX016510
GO:0006664 biological process glycolipid metabolic process The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined (more detail) 100 NA Homo sapiens
WIG001069
Genes involved in Phase 1 Functionalization of compounds (more detail) 69 NA Homo sapiens
TAX025464
GO:0046128 biological process purine ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base (more detail) 69 NA Homo sapiens
WIG001435
Actin Nucleation by ARP WASP Complex Actin Nucleation by ARP-WASP Complex (more detail) 119 NA Homo sapiens
MAX003160
Genes that comprise the mitochondria gene module A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genom (more detail) 201 NA Homo sapiens
MAX000766
Genes required for proliferation of DLD 1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen. Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancer (more detail) 165 NA Homo sapiens
MEX001550
Genes associated with Kinase Inhibitor Cyt387 Genes associated with Kinase Inhibitor Cyt387, curated by the Drug Signature Database (DSigDB). (more detail) 65 25990557 Homo sapiens
MEX000882
Genes associated with Approved Drug nilotinib Genes associated with Approved Drug nilotinib, curated by the Drug Signature Database (DSigDB). (more detail) 65 25990557 Homo sapiens
FOX000483
Genes in the cancer module 152 (more detail) 110 NA Homo sapiens
WIG000980
Genes involved in Metabolism of nucleotides (more detail) 68 NA Homo sapiens
TAX026890
GO:0051239 biological process regulation of multicellular organismal process Any process that modulates the frequency, rate or extent of a multicellular organismal process, the (more detail) 2813 NA Homo sapiens
WIG001607
P2Y Receptor Signaling P2Y Receptor Signaling (more detail) 126 NA Homo sapiens
WIG000525
Glycerophospholipid metabolism (more detail) 71 NA Homo sapiens
MEX002134
Genes associated with Kinase Inhibitor BRD K83972459 001 01 9 Genes associated with Kinase Inhibitor BRD-K83972459-001-01-9, curated by the Drug Signature Databas (more detail) 64 25990557 Homo sapiens
MEX001346
Genes associated with Kinase Inhibitor WZ4002 Genes associated with Kinase Inhibitor WZ4002, curated by the Drug Signature Database (DSigDB). (more detail) 64 25990557 Homo sapiens
TAX024655
GO:0044271 biological process cellular nitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous (more detail) 3324 NA Homo sapiens
TAX000335
Genes annotated by the GO term GO:0006643. The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. (more detail) 100 NA Homo sapiens
TAX023491
GO:0038095 biological process Fc epsilon receptor signaling pathway A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) t (more detail) 121 NA Homo sapiens
IEI014571
Protein protein interactors of human gene UBE2E1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2E1 (SwissProt ID (more detail) 125 17535438 Homo sapiens
WIG001989
Insulin Signaling Insulin Signaling (more detail) 159 NA Homo sapiens
TAX000307
Genes annotated by the GO term GO:0008610. The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. (more detail) 95 NA Homo sapiens
MEX002376
Genes associated with Kinase Inhibitor PHA 665752 Genes associated with Kinase Inhibitor PHA-665752, curated by the Drug Signature Database (DSigDB). (more detail) 63 25990557 Homo sapiens
TAX018953
GO:0016278 molecular function lysine N methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group (more detail) 63 NA Homo sapiens
WIG000610
Retinol metabolism (more detail) 63 NA Homo sapiens
MEX002414
Genes associated with Kinase Inhibitor Ruzolitinib Genes associated with Kinase Inhibitor Ruzolitinib, curated by the Drug Signature Database (DSigDB). (more detail) 63 25990557 Homo sapiens
TAX032170
GO:1901570 biological process fatty acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of fatty acid derivative. (more detail) 78 NA Homo sapiens
WIG001424
Actin Nucleation and Branching Actin Nucleation and Branching (more detail) 101 NA Homo sapiens
TAX019690
GO:0019359 biological process nicotinamide nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucl (more detail) 69 NA Homo sapiens
TAX019692
GO:0019363 biological process pyridine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotid (more detail) 69 NA Homo sapiens
WIG001070
Genes involved in Phase II conjugation (more detail) 69 NA Homo sapiens
MEX001850
Genes associated with Kinase Inhibitor AGN PC 0D0DBW Genes associated with Kinase Inhibitor AGN-PC-0D0DBW, curated by the Drug Signature Database (DSigDB (more detail) 62 25990557 Homo sapiens
TAX015212
GO:0004536 molecular function deoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. (more detail) 62 NA Homo sapiens
TAX018954
GO:0016279 molecular function protein lysine N methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group (more detail) 62 NA Homo sapiens
WIG001717
Ubiquitin Proteasome Dependent Proteolysis Ubiquitin-Proteasome Dependent Proteolysis (more detail) 77 NA Homo sapiens
TAX000088
Genes annotated by the GO term GO:0044265. The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. (more detail) 100 NA Homo sapiens
TAX017478
GO:0009062 biological process fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic (more detail) 84 NA Homo sapiens
TAX001228
Genes annotated by the GO term GO:0016879. Catalysis of the ligation of two substances via a carbon nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. (more detail) 65 NA Homo sapiens
TAX019773
GO:0019674 biological process NAD metabolic process The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme pr (more detail) 68 NA Homo sapiens
WIG000527
Glycolysis / Gluconeogenesis Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (e (more detail) 61 NA Homo sapiens
MEX001543
Genes associated with Kinase Inhibitor Ruxolitinib Genes associated with Kinase Inhibitor Ruxolitinib, curated by the Drug Signature Database (DSigDB). (more detail) 61 25990557 Homo sapiens
TAX017103
GO:0008173 molecular function RNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. (more detail) 61 NA Homo sapiens
TAX020220
GO:0022853 molecular function active ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other up the solute's concentratio (more detail) 61 NA Homo sapiens
TAX019154
GO:0016667 molecular function oxidoreductase activity, acting on a sulfur group of donors Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hy (more detail) 61 NA Homo sapiens
TAX015339
GO:0004714 molecular function transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 61 NA Homo sapiens
TAX023937
GO:0042625 molecular function ATPase coupled ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP (more detail) 61 NA Homo sapiens
TAX017593
GO:0009201 biological process ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a c (more detail) 81 NA Homo sapiens
FOX000436
Genes in the cancer module 107 (more detail) 78 NA Homo sapiens
WIG000878
Genes involved in Glycerophospholipid biosynthesis (more detail) 78 NA Homo sapiens
TAX019833
GO:0019829 molecular function cation transporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 60 NA Homo sapiens
TAX017143
GO:0008235 molecular function metalloexopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus (more detail) 60 NA Homo sapiens
MOX005046
Genes associated with Computational Drug Signature staurosporine Genes associated with Computational Drug Signature staurosporine, curated by the Drug Signature Data (more detail) 169 25990557 Homo sapiens
TAX019840
GO:0019842 molecular function vitamin binding Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic subs (more detail) 134 NA Homo sapiens
TAX016571
GO:0006749 biological process glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, (more detail) 63 NA Homo sapiens
TAX017579
GO:0009185 biological process ribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of (more detail) 63 NA Homo sapiens
WIG001209
Genes involved in Signaling by Insulin receptor (more detail) 106 NA Homo sapiens
WIG001729
Yersinia Infection Yersinia Infection (more detail) 79 NA Homo sapiens
MEX002406
Genes associated with Kinase Inhibitor Sorafenib Genes associated with Kinase Inhibitor Sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 59 25990557 Homo sapiens
WAG000194
Retinol metabolism (more detail) 59 NA Homo sapiens
TAX023646
GO:0042054 molecular function histone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-hi (more detail) 59 NA Homo sapiens
TAX026924
GO:0051287 molecular function NAD binding Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involv (more detail) 59 NA Homo sapiens
TAX000703
Genes annotated by the GO term GO:0006974. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. (more detail) 157 NA Homo sapiens
TAX017480
GO:0009064 biological process glutamine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the glutamine family, comprising argini (more detail) 68 NA Homo sapiens
TAX001281
Genes annotated by the GO term GO:0016614. Catalysis of an oxidation reduction (redox) reaction in which a CH OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. (more detail) 62 NA Homo sapiens
WAG001218
Glycan structures biosynthesis 2 (more detail) 62 NA Homo sapiens
TAX025480
GO:0046165 biological process alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compou (more detail) 90 NA Homo sapiens
TAX022649
GO:0034754 biological process cellular hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted b (more detail) 107 NA Homo sapiens
WIG001589
NFAT in Immune Response NFAT in Immune Response (more detail) 169 NA Homo sapiens
WAG001429
Porphyrin and chlorophyll metabolism (more detail) 58 NA Homo sapiens
MEX002129
Genes associated with Kinase Inhibitor Flavopiridol Genes associated with Kinase Inhibitor Flavopiridol, curated by the Drug Signature Database (DSigDB) (more detail) 58 25990557 Homo sapiens
TAX025820
GO:0046939 biological process nucleotide phosphorylation The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylate (more detail) 58 NA Homo sapiens
TAX028564
GO:0061733 molecular function peptide lysine N acetyltransferase activity Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. (more detail) 58 NA Homo sapiens
TAX027224
GO:0051865 biological process protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an ide (more detail) 58 NA Homo sapiens
TAX019135
GO:0016627 molecular function oxidoreductase activity, acting on the CH CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or el (more detail) 58 NA Homo sapiens
TAX019639
GO:0019213 molecular function deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. (more detail) 58 NA Homo sapiens
MAX000461
Top 200 marker genes down regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation, high levels of serum AFP [GeneID=174] , and chromosomal instability. Hepatocellular carcinomas represent the third leading cause of cancer-related deaths worldwide. The (more detail) 172 NA Homo sapiens
TAX000157
Genes annotated by the GO term GO:0016311. The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. (more detail) 67 NA Homo sapiens
WIG001599
AMPK Enzyme Complex Pathway AMPK Enzyme Complex Pathway (more detail) 110 NA Homo sapiens
WIG001977
cytochrome P450 cytochrome P450 (more detail) 61 NA Homo sapiens
TAX017573
GO:0009179 biological process purine ribonucleoside diphosphate metabolic process The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisti (more detail) 61 NA Homo sapiens
TAX017533
GO:0009135 biological process purine nucleoside diphosphate metabolic process The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting o (more detail) 61 NA Homo sapiens
TAX016116
GO:0006081 biological process cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH= (more detail) 64 NA Homo sapiens
WAG000378
Tyrosine metabolism (more detail) 57 NA Homo sapiens
TAX019200
GO:0016763 molecular function transferase activity, transferring pentosyl groups Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). (more detail) 57 NA Homo sapiens
TAX019249
GO:0016836 molecular function hydro lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. (more detail) 57 NA Homo sapiens
TAX016078
GO:0006022 biological process aminoglycan metabolic process The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that (more detail) 160 NA Homo sapiens
TAX022405
GO:0034308 biological process primary alcohol metabolic process The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in (more detail) 69 NA Homo sapiens
TAX019445
GO:0018022 biological process peptidyl lysine methylation The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. (more detail) 79 NA Homo sapiens
TAX034340
GO:1990748 biological process cellular detoxification Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substa (more detail) 88 NA Homo sapiens
TAX026852
GO:0051179 biological process localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organel (more detail) 4590 NA Homo sapiens
TAX017543
GO:0009145 biological process purine nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a (more detail) 76 NA Homo sapiens
WIG001836
MAPK signaling The transmission of extracellular signals into their intracellular targets is mediated by a network (more detail) 141 NA Homo sapiens
WIG001963
MAPK signaling pathway MAPK signaling pathway (more detail) 159 NA Homo sapiens
MEX001357
Genes associated with Kinase Inhibitor BX 795 Genes associated with Kinase Inhibitor BX-795, curated by the Drug Signature Database (DSigDB). (more detail) 56 25990557 Homo sapiens
TAX016162
GO:0006165 biological process nucleoside diphosphate phosphorylation The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside t (more detail) 56 NA Homo sapiens
TAX015116
GO:0004402 molecular function histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. (more detail) 56 NA Homo sapiens
MOX015198
Genes associated with Computational Drug Signature staurosporine Genes associated with Computational Drug Signature staurosporine, curated by the Drug Signature Data (more detail) 120 25990557 Homo sapiens
TAX001424
Genes annotated by the GO term GO:0016746. Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). (more detail) 59 NA Homo sapiens
TAX017598
GO:0009206 biological process purine ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate (more detail) 75 NA Homo sapiens
TAX020228
GO:0022904 biological process respiratory electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors (more detail) 82 NA Homo sapiens
TAX000181
Genes annotated by the GO term GO:0006281. The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double strand break repair pathway, and mismatch repair pathway. (more detail) 123 NA Homo sapiens
WIG001754
mTOR Pathway mTOR Pathway (more detail) 115 NA Homo sapiens
MEX002358
Genes associated with Kinase Inhibitor JAK3 Inhibitor VI Genes associated with Kinase Inhibitor JAK3 Inhibitor VI, curated by the Drug Signature Database (DS (more detail) 55 25990557 Homo sapiens
MEX002395
Genes associated with Kinase Inhibitor Vandetanib Genes associated with Kinase Inhibitor Vandetanib, curated by the Drug Signature Database (DSigDB). (more detail) 55 25990557 Homo sapiens
WAG001443
Pyruvate metabolism (more detail) 55 NA Homo sapiens
MEX001371
Genes associated with Kinase Inhibitor Sorafenib Genes associated with Kinase Inhibitor Sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 55 25990557 Homo sapiens
WIG000623
Steroid hormone biosynthesis Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrate (more detail) 55 NA Homo sapiens
MEX001456
Genes associated with Kinase Inhibitor Vandetanib Genes associated with Kinase Inhibitor Vandetanib, curated by the Drug Signature Database (DSigDB). (more detail) 55 25990557 Homo sapiens
MEX002061
Genes associated with Kinase Inhibitor 878739 06 1 Genes associated with Kinase Inhibitor 878739-06-1, curated by the Drug Signature Database (DSigDB). (more detail) 55 25990557 Homo sapiens
FOX000541
Genes in the cancer module 209 (more detail) 88 NA Homo sapiens
WAG000083
Electron Transport Chain (more detail) 61 NA Homo sapiens
TAX031113
GO:0098754 biological process detoxification Any process that reduces or removes the toxicity of a toxic substance. These may include transport o (more detail) 92 NA Homo sapiens
FOX000562
Genes in the cancer module 235 (more detail) 81 NA Homo sapiens
WIG000591
Phosphatidylinositol signaling system (more detail) 76 NA Homo sapiens
MEX001851
Genes associated with Kinase Inhibitor GW305074X Genes associated with Kinase Inhibitor GW305074X, curated by the Drug Signature Database (DSigDB). (more detail) 54 25990557 Homo sapiens
MEX002381
Genes associated with Kinase Inhibitor Neratinib Genes associated with Kinase Inhibitor Neratinib, curated by the Drug Signature Database (DSigDB). (more detail) 54 25990557 Homo sapiens
WIG000545
Inositol phosphate metabolism (more detail) 54 NA Homo sapiens
MEX001204
Genes associated with Kinase Inhibitor Ro 31 8220 mesylate Genes associated with Kinase Inhibitor Ro 31-8220 mesylate, curated by the Drug Signature Database ( (more detail) 54 25990557 Homo sapiens
TAX027442
GO:0052742 molecular function phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. (more detail) 54 NA Homo sapiens
TAX019244
GO:0016830 molecular function carbon carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely (more detail) 54 NA Homo sapiens
TAX029234
GO:0070988 biological process demethylation The process of removing one or more methyl groups from a molecule. (more detail) 60 NA Homo sapiens
TAX025541
GO:0046365 biological process monosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcoho (more detail) 60 NA Homo sapiens
TAX016195
GO:0006220 biological process pyrimidine nucleotide metabolic process The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucl (more detail) 60 NA Homo sapiens
TAX031140
GO:0098803 cellular component respiratory chain complex Any protein complex that is part of a respiratory chain (more detail) 73 NA Homo sapiens
TAX000051
Genes annotated by the GO term GO:0043285. The chemical reactions and pathways resulting in the breakdown of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. (more detail) 113 NA Homo sapiens
WIG001673
Signaling Involved in Cardiac Hypertrophy Signaling Involved in Cardiac Hypertrophy (more detail) 157 NA Homo sapiens
TAX026886
GO:0051234 biological process establishment of localization Any process that localizes a substance or cellular component. This may occur via movement, tethering (more detail) 4136 NA Homo sapiens
TAX031173
GO:0098869 biological process cellular oxidant detoxification Any process carried out at the cellular level that reduces or removes the toxicity superoxide radica (more detail) 84 NA Homo sapiens
MEX001227
Genes associated with Kinase Inhibitor 718630 59 2 Genes associated with Kinase Inhibitor 718630-59-2, curated by the Drug Signature Database (DSigDB). (more detail) 53 25990557 Homo sapiens
TAX019697
GO:0019369 biological process arachidonic acid metabolic process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 (more detail) 53 NA Homo sapiens
TAX023250
GO:0036092 biological process phosphatidylinositol 3 phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, (more detail) 53 NA Homo sapiens
MAX001963
Genes involved in oxidative phosphorylation; based on literature and sequence annotation resources and converted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 70 NA Homo sapiens
TAX023492
GO:0038096 biological process Fc gamma receptor signaling pathway involved in phagocytosis An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external part (more detail) 133 NA Homo sapiens
TAX014234
GO:0002433 biological process immune response regulating cell surface receptor signaling pathway involved in phagocytosis An immune response-regulating cell surface receptor signaling pathway that contributes to the endocy (more detail) 133 NA Homo sapiens
TAX001065
Genes annotated by the GO term GO:0016881. Catalysis of the ligation of an acid to an amino acid via a carbon nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. (more detail) 56 NA Homo sapiens
TAX001289
Genes annotated by the GO term GO:0016616. Catalysis of an oxidation reduction (redox) reaction in which a CH OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. (more detail) 56 NA Homo sapiens
IEI014569
Protein protein interactors of human gene UBE2D4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2D4 (SwissProt ID (more detail) 98 17535438 Homo sapiens
WIG001204
Genes involved in Signaling by FGFR in disease (more detail) 121 NA Homo sapiens
WAG000397
Fatty acid metabolism (more detail) 52 NA Homo sapiens
WAG000614
Folate biosynthesis (more detail) 52 NA Homo sapiens
TAX017089
GO:0008146 molecular function sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydro (more detail) 52 NA Homo sapiens
WAG001217
Androgen and estrogen metabolism (more detail) 52 NA Homo sapiens
TAX019276
GO:0016879 molecular function ligase activity, forming carbon nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitr (more detail) 52 NA Homo sapiens
MEX002048
Genes associated with Kinase Inhibitor 1,9 Pyrazoloanthrone Genes associated with Kinase Inhibitor 1,9-Pyrazoloanthrone, curated by the Drug Signature Database (more detail) 52 25990557 Homo sapiens
FOX000819
Genes in the cancer module 62 (more detail) 76 NA Homo sapiens
TAX000352
Genes annotated by the GO term GO:0032787. The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO ). (more detail) 87 NA Homo sapiens
WIG001588
NFAT and Cardiac Hypertrophy NFAT and Cardiac Hypertrophy (more detail) 115 NA Homo sapiens
TAX000536
Genes annotated by the GO term GO:0006470. The process of removing one or more phosphoric residues from a protein. (more detail) 61 NA Homo sapiens
TAX019494
GO:0018208 biological process peptidyl proline modification The modification of peptidyl-proline. (more detail) 55 NA Homo sapiens
WIG000475
Arachidonic acid metabolism (more detail) 58 NA Homo sapiens
TAX019571
GO:0019003 molecular function GDP binding Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. (more detail) 58 NA Homo sapiens
TAX014232
GO:0002431 biological process Fc receptor mediated stimulatory signaling pathway A series of molecular signals generated as a consequence of a the binding of the Fc portion of an im (more detail) 135 NA Homo sapiens
TAX016607
GO:0006810 biological process transport The directed movement of substances (such as macromolecules, small molecules, ions) or cellular comp (more detail) 4023 NA Homo sapiens
TAX030550
GO:0090502 biological process RNA phosphodiester bond hydrolysis, endonucleolytic The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds (more detail) 80 NA Homo sapiens
TAX018912
GO:0016209 molecular function antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is (more detail) 80 NA Homo sapiens
TAX019097
GO:0016571 biological process histone methylation The modification of histones by addition of methyl groups. (more detail) 84 NA Homo sapiens
TAX001341
Genes annotated by the GO term GO:0004713. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. (more detail) 63 NA Homo sapiens
TAX032182
GO:1901607 biological process alpha amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of an alpha-amino acid. (more detail) 63 NA Homo sapiens
WAG000201
Arachidonic acid metabolism (more detail) 51 NA Homo sapiens
TAX001439
Genes annotated by the GO term GO:0019199. (more detail) 51 NA Homo sapiens
TAX001182
Genes annotated by the GO term GO:0004386. Catalysis of the unwinding of a DNA or RNA duplex. (more detail) 51 NA Homo sapiens
WIG000507
Drug metabolism other enzymes (more detail) 51 NA Homo sapiens
WAG000404
Butanoate metabolism (more detail) 51 NA Homo sapiens
TAX017227
GO:0008375 molecular function acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a suga (more detail) 51 NA Homo sapiens
TAX030034
GO:0072523 biological process purine containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. (more detail) 51 NA Homo sapiens
TAX017249
GO:0008408 molecular function 3' 5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues f (more detail) 51 NA Homo sapiens
TAX015340
GO:0004715 molecular function non membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-me (more detail) 51 NA Homo sapiens
TAX031323
GO:0099132 biological process ATP hydrolysis coupled cation transmembrane transport The transport of an inorganic cation across a membrane and against an electrochemical gradient, usin (more detail) 51 NA Homo sapiens
TAX020328
GO:0030145 molecular function manganese ion binding Interacting selectively and non-covalently with manganese (Mn) ions. (more detail) 51 NA Homo sapiens
TAX019150
GO:0016655 molecular function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or el (more detail) 51 NA Homo sapiens
TAX017482
GO:0009066 biological process aspartate family amino acid metabolic process The chemical reactions and pathways involving amino acids of the aspartate family, comprising aspara (more detail) 54 NA Homo sapiens
TAX021607
GO:0032508 biological process DNA duplex unwinding The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', ge (more detail) 57 NA Homo sapiens
TAX023490
GO:0038094 biological process Fc gamma receptor signaling pathway A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) t (more detail) 137 NA Homo sapiens
TAX016536
GO:0006694 biological process steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyc (more detail) 126 NA Homo sapiens
TAX026374
GO:0048856 biological process anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an (more detail) 3198 NA Homo sapiens
WIG001237
Genes involved in Sphingolipid metabolism (more detail) 62 NA Homo sapiens
TAX015987
GO:0005875 cellular component microtubule associated complex Any multimeric complex connected to a microtubule. (more detail) 144 NA Homo sapiens
MEX002421
Genes associated with Kinase Inhibitor Cabozantinib Genes associated with Kinase Inhibitor Cabozantinib, curated by the Drug Signature Database (DSigDB) (more detail) 50 25990557 Homo sapiens
WIG000523
Glutathione metabolism (more detail) 50 NA Homo sapiens
TAX001129
Genes annotated by the GO term GO:0008234. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. (more detail) 50 NA Homo sapiens
TAX017226
GO:0008374 molecular function O acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. (more detail) 50 NA Homo sapiens
TAX019264
GO:0016860 molecular function intramolecular oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are th (more detail) 50 NA Homo sapiens
TAX019223
GO:0016796 molecular function exonuclease activity, active with either ribo or deoxyribonucleic acids and producing 5' phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues f (more detail) 50 NA Homo sapiens
TAX014756
GO:0003678 molecular function DNA helicase activity Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. (more detail) 50 NA Homo sapiens
WIG001470
DNA Repair Mechanism DNA Repair Mechanism (more detail) 105 NA Homo sapiens
TAX016518
GO:0006672 biological process ceramide metabolic process The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. (more detail) 76 NA Homo sapiens
MOX003562
Genes associated with Computational Drug Signature PONATINIB Genes associated with Computational Drug Signature PONATINIB, curated by the Drug Signature Database (more detail) 59 25990557 Homo sapiens
TAX016355
GO:0006473 biological process protein acetylation The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from ace (more detail) 129 NA Homo sapiens
PEX000656
Trypsin: Trypsin (more detail) 53 NA Homo sapiens
IEI007770
Protein protein interactors of human gene MBP from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MBP (SwissProt ID=P0 (more detail) 80 17535438 Homo sapiens
TAX013666
GO:0001510 biological process RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonu (more detail) 71 NA Homo sapiens
WIG000579
Oxidative phosphorylation (more detail) 143 NA Homo sapiens
MEX001876
Genes associated with Kinase Inhibitor AZD 9291 Genes associated with Kinase Inhibitor AZD-9291, curated by the Drug Signature Database (DSigDB). (more detail) 49 25990557 Homo sapiens
WAG000380
Drug metabolism other enzymes (more detail) 49 NA Homo sapiens
MEX002401
Genes associated with Kinase Inhibitor Pazopanib Genes associated with Kinase Inhibitor Pazopanib, curated by the Drug Signature Database (DSigDB). (more detail) 49 25990557 Homo sapiens
MEX001534
Genes associated with Kinase Inhibitor Pazopanib Genes associated with Kinase Inhibitor Pazopanib, curated by the Drug Signature Database (DSigDB). (more detail) 49 25990557 Homo sapiens
MEX001333
Genes associated with Kinase Inhibitor Staurosporine, N Benzoyl Genes associated with Kinase Inhibitor Staurosporine, N-Benzoyl, curated by the Drug Signature Datab (more detail) 49 25990557 Homo sapiens
MEX002248
Genes associated with Kinase Inhibitor Go 6976 Genes associated with Kinase Inhibitor Go 6976, curated by the Drug Signature Database (DSigDB). (more detail) 49 25990557 Homo sapiens
TAX026497
GO:0050661 molecular function NADP binding Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenz (more detail) 49 NA Homo sapiens
TAX023482
GO:0038083 biological process peptidyl tyrosine autophosphorylation The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosi (more detail) 49 NA Homo sapiens
TAX031996
GO:1901068 biological process guanosine containing compound metabolic process The chemical reactions and pathways involving guanosine-containing compounds (guanosines). (more detail) 49 NA Homo sapiens
TAX032215
GO:1901659 biological process glycosyl compound biosynthetic process The chemical reactions and pathways resulting in the formation of glycosyl compound. (more detail) 49 NA Homo sapiens
TAX019470
GO:0018130 biological process heterocycle biosynthetic process The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with (more detail) 3045 NA Homo sapiens
TAX022489
GO:0034440 biological process lipid oxidation The removal of one or more electrons from a lipid, with or without the concomitant removal of a prot (more detail) 77 NA Homo sapiens
TAX001342
Genes annotated by the GO term GO:0004725. Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. (more detail) 52 NA Homo sapiens
TAX016580
GO:0006766 biological process vitamin metabolic process The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of un (more detail) 116 NA Homo sapiens
MEX001296
Genes associated with Kinase Inhibitor Ruboxistaurin Genes associated with Kinase Inhibitor Ruboxistaurin, curated by the Drug Signature Database (DSigDB (more detail) 48 25990557 Homo sapiens
WAG000993
Citrate cycle (TCA cycle) The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the fil steps of the (more detail) 48 NA Homo sapiens
WAG000188
Glutathione metabolism (more detail) 48 NA Homo sapiens
TAX019631
GO:0019205 molecular function nucleobase containing compound kinase activity Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside (more detail) 48 NA Homo sapiens
TAX029196
GO:0070936 biological process protein K48 linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine (more detail) 48 NA Homo sapiens
TAX022591
GO:0034656 biological process nucleobase containing small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small mole (more detail) 48 NA Homo sapiens
TAX019709
GO:0019395 biological process fatty acid oxidation The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a (more detail) 76 NA Homo sapiens
TAX016303
GO:0006400 biological process tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule (more detail) 76 NA Homo sapiens
TAX001268
Genes annotated by the GO term GO:0004518. Catalysis of the hydrolysis of ester linkages within nucleic acids. (more detail) 54 NA Homo sapiens
TAX030039
GO:0072528 biological process pyrimidine containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, (more detail) 54 NA Homo sapiens
WIG000476
Arginine and proline metabolism (more detail) 51 NA Homo sapiens
FEX001656
Leukemia Tavolaro10 56genes Table 3. PK genes highly and specifically expressed in CLL. (more detail) 51 20036005 Homo sapiens
TAX001387
Genes annotated by the GO term GO:0008639. Catalysis of the covalent attachment of small proteins, such as ubiquitin or ubiquitin like proteins, to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3, ubiquitin like protein ligase. (more detail) 51 NA Homo sapiens
TAX000227
Genes annotated by the GO term GO:0006091. The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. (more detail) 121 NA Homo sapiens
TAX016371
GO:0006493 biological process protein O linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to (more detail) 100 NA Homo sapiens
TAX021011
GO:0031463 cellular component Cul3 RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form (more detail) 71 NA Homo sapiens
TAX019725
GO:0019438 biological process aromatic compound biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance (more detail) 3051 NA Homo sapiens
TAX000024
Genes annotated by the GO term GO:0006519. The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids. (more detail) 94 NA Homo sapiens
TAX001238
Genes annotated by the GO term GO:0000287. Interacting selectively with magnesium (Mg) ions. (more detail) 59 NA Homo sapiens
MEX001248
Genes associated with Kinase Inhibitor Ro 3306 Genes associated with Kinase Inhibitor Ro-3306, curated by the Drug Signature Database (DSigDB). (more detail) 47 25990557 Homo sapiens
WAG001223
Tryptophan metabolism (more detail) 47 NA Homo sapiens
TAX001274
Genes annotated by the GO term GO:0016779. Catalysis of the transfer of a nucleotidyl group to a reactant. (more detail) 47 NA Homo sapiens
FEX001051
Eye+J425 Hendig09 48genes Table 1. Gene expression profile of ABC transporters of control cDNA and cDNA derived from Y79 cells (more detail) 47 19266166 Homo sapiens
MEX001345
Genes associated with Kinase Inhibitor GSK690693 Genes associated with Kinase Inhibitor GSK690693, curated by the Drug Signature Database (DSigDB). (more detail) 47 25990557 Homo sapiens
TAX019163
GO:0016684 molecular function oxidoreductase activity, acting on peroxide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen (more detail) 47 NA Homo sapiens
TAX019167
GO:0016706 molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2 oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduc (more detail) 47 NA Homo sapiens
TAX019447
GO:0018024 molecular function histone lysine N methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + (more detail) 47 NA Homo sapiens
TAX017560
GO:0009163 biological process nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic mol (more detail) 47 NA Homo sapiens
TAX021507
GO:0032392 biological process DNA geometric change The process in which a transformation is induced in the geometry of a DNA double helix, resulting in (more detail) 66 NA Homo sapiens
TAX017657
GO:0009311 biological process oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (abou (more detail) 56 NA Homo sapiens
TAX029286
GO:0071103 biological process DNA conformation change A cellular process that results in a change in the spatial configuration of a DNA molecule. A confor (more detail) 107 NA Homo sapiens
TAX001383
Genes annotated by the GO term GO:0019787. Catalysis of ATP dependent isopeptide bond formation between the carboxy terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin like protein, and a substrate lysine residue. (more detail) 50 NA Homo sapiens
WIG000781
Genes involved in Cytochrome P450 arranged by substrate type (more detail) 50 NA Homo sapiens
WIG001200
Genes involved in Signaling by FGFR (more detail) 108 NA Homo sapiens
TAX022138
GO:0033558 molecular function protein deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. (more detail) 46 NA Homo sapiens
MEX002045
Genes associated with Kinase Inhibitor Cediranib Genes associated with Kinase Inhibitor Cediranib, curated by the Drug Signature Database (DSigDB). (more detail) 46 25990557 Homo sapiens
TAX015029
GO:0004177 molecular function aminopeptidase activity Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. (more detail) 46 NA Homo sapiens
TAX018967
GO:0016303 molecular function 1 phosphatidylinositol 3 kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3 (more detail) 46 NA Homo sapiens
TAX001369
Genes annotated by the GO term GO:0017171. Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). (more detail) 46 NA Homo sapiens
TAX000468
Genes annotated by the GO term GO:0006644. The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono or diester. (more detail) 74 NA Homo sapiens
TAX016372
GO:0006497 biological process protein lipidation The covalent attachment of lipid groups to an amino acid in a protein. (more detail) 76 NA Homo sapiens
TAX016123
GO:0006090 biological process pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. (more detail) 67 NA Homo sapiens
TAX017690
GO:0009435 biological process NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, (more detail) 52 NA Homo sapiens
WIG000621
Starch and sucrose metabolism (more detail) 52 NA Homo sapiens
WIG000712
Genes involved in Asparagine N linked glycosylation (more detail) 80 NA Homo sapiens
TAX001427
Genes annotated by the GO term GO:0016747. Catalysis of the transfer of an acyl group, other than amino acyl, from one compound (donor) to another (acceptor). (more detail) 49 NA Homo sapiens
TAX016191
GO:0006213 biological process pyrimidine nucleoside metabolic process The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic (more detail) 49 NA Homo sapiens
TAX016045
GO:0005976 biological process polysaccharide metabolic process The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more th (more detail) 73 NA Homo sapiens
TAX016575
GO:0006754 biological process ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a (more detail) 64 NA Homo sapiens
WIG000537
GnRH signaling pathway Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the (more detail) 101 NA Homo sapiens
TAX001195
Genes annotated by the GO term GO:0016810. Catalysis of the hydrolysis of any carbon nitrogen bond, C N, with the exception of peptide bonds. (more detail) 45 NA Homo sapiens
MEX001422
Genes associated with Kinase Inhibitor 929095 18 1 Genes associated with Kinase Inhibitor 929095-18-1, curated by the Drug Signature Database (DSigDB). (more detail) 45 25990557 Homo sapiens
MEX002029
Genes associated with Kinase Inhibitor SU11652 Genes associated with Kinase Inhibitor SU11652, curated by the Drug Signature Database (DSigDB). (more detail) 45 25990557 Homo sapiens
TAX001372
Genes annotated by the GO term GO:0008236. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). (more detail) 45 NA Homo sapiens
MEX001976
Genes associated with Kinase Inhibitor SureCN186278 Genes associated with Kinase Inhibitor SureCN186278, curated by the Drug Signature Database (DSigDB) (more detail) 45 25990557 Homo sapiens
TAX017083
GO:0008138 molecular function protein tyrosine/serine/threonine phosphatase activity Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine pho (more detail) 45 NA Homo sapiens
TAX024491
GO:0043647 biological process inositol phosphate metabolic process The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with (more detail) 54 NA Homo sapiens
WIG001504
FGF Pathway FGF Pathway (more detail) 77 NA Homo sapiens
WIG001566
Alpha Adrenergic Signaling Alpha-Adrenergic Signaling (more detail) 59 NA Homo sapiens
WIG000515
Fc epsilon RI signaling pathway Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (more detail) 79 NA Homo sapiens
WIG001957
G Protein Signaling Pathways G Protein Signaling Pathways (more detail) 93 NA Homo sapiens
TAX026859
GO:0051187 biological process cofactor catabolic process The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is re (more detail) 51 NA Homo sapiens
TAX015931
GO:0005782 cellular component peroxisomal matrix The volume contained within the membranes of a peroxisome; in many cells the matrix contains a cryst (more detail) 51 NA Homo sapiens
TAX021226
GO:0031907 cellular component microbody lumen The volume enclosed by the membranes of a microbody. (more detail) 51 NA Homo sapiens
TAX020347
GO:0030170 molecular function pyridoxal phosphate binding Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)- (more detail) 51 NA Homo sapiens
TAX028841
GO:0070279 molecular function vitamin B6 binding Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxa (more detail) 51 NA Homo sapiens
TAX001245
Genes annotated by the GO term GO:0008237. (more detail) 48 NA Homo sapiens
TAX001445
Genes annotated by the GO term GO:0004842. Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N ubiquityllysine. (more detail) 48 NA Homo sapiens
IEI007708
Protein protein interactors of human gene MAPT from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MAPT (SwissProt ID=P (more detail) 98 17535438 Homo sapiens
TAX020517
GO:0030449 biological process regulation of complement activation Any process that modulates the frequency, rate or extent of complement activation. (more detail) 111 NA Homo sapiens
WIG000809
Genes involved in Downstream signaling of activated FGFR (more detail) 96 NA Homo sapiens
WIG001984
Tryptophan metabolism Tryptophan metabolism (more detail) 44 NA Homo sapiens
MEX002353
Genes associated with Kinase Inhibitor BRD K72636697 001 01 5 Genes associated with Kinase Inhibitor BRD-K72636697-001-01-5, curated by the Drug Signature Databas (more detail) 44 25990557 Homo sapiens
WIG000461
ABC transporters The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are (more detail) 44 NA Homo sapiens
MEX002205
Genes associated with Kinase Inhibitor PKR Inhibitor Genes associated with Kinase Inhibitor PKR Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 44 25990557 Homo sapiens
MEX001577
Genes associated with Kinase Inhibitor 331771 20 1 Genes associated with Kinase Inhibitor 331771-20-1, curated by the Drug Signature Database (DSigDB). (more detail) 44 25990557 Homo sapiens
TAX016181
GO:0006195 biological process purine nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound co (more detail) 44 NA Homo sapiens
TAX019297
GO:0016903 molecular function oxidoreductase activity, acting on the aldehyde or oxo group of donors Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts (more detail) 44 NA Homo sapiens
TAX015256
GO:0004601 molecular function peroxidase activity Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. (more detail) 44 NA Homo sapiens
TAX015117
GO:0004407 molecular function histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This react (more detail) 44 NA Homo sapiens
TAX019289
GO:0016893 molecular function endonuclease activity, active with either ribo or deoxyribonucleic acids and producing 5' phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yi (more detail) 44 NA Homo sapiens
TAX015030
GO:0004180 molecular function carboxypeptidase activity Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a p (more detail) 44 NA Homo sapiens
TAX000140
Genes annotated by the GO term GO:0051186. The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. (more detail) 53 NA Homo sapiens
WAG000811
Fc epsilon RI signaling pathway Fc epsilon RI-mediated sigling pathways in mast cells are initiated by the interaction of antigen (A (more detail) 65 NA Homo sapiens
TAX022673
GO:0034968 biological process histone lysine methylation The modification of a histone by addition of one or more methyl groups to a lysine residue. (more detail) 65 NA Homo sapiens
WIG000512
ErbB signaling pathway The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor l (more detail) 86 NA Homo sapiens
TAX019677
GO:0019320 biological process hexose catabolic process The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a (more detail) 50 NA Homo sapiens
WIG001693
Thrombin Signaling Thrombin Signaling (more detail) 105 NA Homo sapiens
TAX025401
GO:0046031 biological process ADP metabolic process The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. (more detail) 47 NA Homo sapiens
TAX015984
GO:0005871 cellular component kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related prot (more detail) 55 NA Homo sapiens
TAX031137
GO:0098800 cellular component inner mitochondrial membrane protein complex Any protein complex that is part of the inner mitochondrial membrane. (more detail) 112 NA Homo sapiens
TAX034561
GO:2000257 biological process regulation of protein activation cascade Any process that modulates the frequency, rate or extent of protein activation cascade. (more detail) 112 NA Homo sapiens
MOX001678
Genes associated with Computational Drug Signature myricetin Genes associated with Computational Drug Signature myricetin, curated by the Drug Signature Database (more detail) 99 25990557 Homo sapiens
WIG000882
Genes involved in Glycosaminoglycan metabolism (more detail) 108 NA Homo sapiens
WIG000640
Valine, leucine and isoleucine degradation (more detail) 43 NA Homo sapiens
TAX001441
Genes annotated by the GO term GO:0004714. Catalysis of the reaction: ATP + a protein L tyrosine = ADP + a protein L tyrosine phosphate, to initiate a change in cell activity. (more detail) 43 NA Homo sapiens
WIG000524
Glycerolipid metabolism (more detail) 43 NA Homo sapiens
MEX002405
Genes associated with Kinase Inhibitor Vemurafenib Genes associated with Kinase Inhibitor Vemurafenib, curated by the Drug Signature Database (DSigDB). (more detail) 43 25990557 Homo sapiens
WAG000387
Thiamine metabolism (more detail) 43 NA Homo sapiens
MEX001367
Genes associated with Kinase Inhibitor Linifanib Genes associated with Kinase Inhibitor Linifanib, curated by the Drug Signature Database (DSigDB). (more detail) 43 25990557 Homo sapiens
TAX018446
GO:0015036 molecular function disulfide oxidoreductase activity Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide (more detail) 43 NA Homo sapiens
WIG000597
Progesterone mediated oocyte maturation Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the s (more detail) 85 NA Homo sapiens
WAG000200
Gap junction Gap junctions contain intercellular channels that allow direct communication between the cytosolic c (more detail) 83 NA Homo sapiens
TAX017628
GO:0009247 biological process glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-ac (more detail) 57 NA Homo sapiens
TAX032189
GO:1901616 biological process organic hydroxy compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. (more detail) 64 NA Homo sapiens
WIG000800
Genes involved in DNA Repair (more detail) 102 NA Homo sapiens
TAX016357
GO:0006475 biological process internal protein amino acid acetylation The addition of an acetyl group to a non-terminal amino acid in a protein. (more detail) 113 NA Homo sapiens
FEX001679
Leukemia Messina10 53genes Table 3. PK Genes Distinctive of Each ALL Subgroup (more detail) 46 20564080 Homo sapiens
WIG000574
N Glycan biosynthesis N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glyc (more detail) 46 NA Homo sapiens
WAG001630
N Glycan biosynthesis N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glyc (more detail) 46 NA Homo sapiens
TAX017941
GO:0010501 biological process RNA secondary structure unwinding The process in which a secondary structure of RNA are broken or 'melted'. (more detail) 46 NA Homo sapiens
WIG001659
Retinol Metabolism in Human Liver Retinol Metabolism in Human Liver (more detail) 59 NA Homo sapiens
MOX002422
Genes associated with Computational Drug Signature docetaxel Genes associated with Computational Drug Signature docetaxel, curated by the Drug Signature Database (more detail) 109 25990557 Homo sapiens
WEX000001
Amino Acid Synthesis & Transport The genes related to amino acid synthesis & transport (metabolism) in tumor, immune, stroma using ne (more detail) 54 NA Homo sapiens
WIG001823
Base excision and single strand break repair Base excision repair (BER) is primarily responsible for removing small, non-helix distorting base le (more detail) 94 NA Homo sapiens
TAX017654
GO:0009308 biological process amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character (more detail) 61 NA Homo sapiens
TAX000242
Genes annotated by the GO term GO:0009100. The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. (more detail) 88 NA Homo sapiens
WIG000521
Gap junction Gap junctions contain intercellular channels that allow direct communication between the cytosolic c (more detail) 88 NA Homo sapiens
IEI014597
Protein protein interactors of human gene UBE2W from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2W (SwissProt ID= (more detail) 76 17535438 Homo sapiens
WAG000603
GnRH signaling pathway Godotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the an (more detail) 86 NA Homo sapiens
IEI014582
Protein protein interactors of human gene UBE2L3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2L3 (SwissProt ID (more detail) 114 17535438 Homo sapiens
TAX000214
Genes annotated by the GO term GO:0006631. The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. (more detail) 63 NA Homo sapiens
FEX001590
Leukemia Sanchez Guijo08 67genes Supplementary Table 2p. Genes differentially expressed in Normal bone marrow (BM) samples and comple (more detail) 63 18722011 Homo sapiens
TAX024050
GO:0042866 biological process pyruvate biosynthetic process The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate. (more detail) 42 NA Homo sapiens
TAX034406
GO:1990939 molecular function ATP dependent microtubule motor activity Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP. (more detail) 42 NA Homo sapiens
TAX015337
GO:0004712 molecular function protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein (more detail) 42 NA Homo sapiens
TAX022291
GO:0034061 molecular function DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synth (more detail) 42 NA Homo sapiens
TAX019263
GO:0016859 molecular function cis trans isomerase activity Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or (more detail) 42 NA Homo sapiens
WAG000807
Valine, leucine and isoleucine degradation (more detail) 42 NA Homo sapiens
FOX000844
Genes in the cancer module 86 (more detail) 42 NA Homo sapiens
WIG000471
Amino sugar and nucleotide sugar metabolism (more detail) 42 NA Homo sapiens
WAG000994
Fructose and mannose metabolism (more detail) 42 NA Homo sapiens
MEX002372
Genes associated with Kinase Inhibitor Sorafenib Genes associated with Kinase Inhibitor Sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 42 25990557 Homo sapiens
WAG000198
Inositol phosphate metabolism (more detail) 42 NA Homo sapiens
WIG000514
Fatty acid metabolism (more detail) 42 NA Homo sapiens
MEX001977
Genes associated with Kinase Inhibitor MLN8054 Genes associated with Kinase Inhibitor MLN8054, curated by the Drug Signature Database (DSigDB). (more detail) 42 25990557 Homo sapiens
TAX016366
GO:0006487 biological process protein N linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to (more detail) 65 NA Homo sapiens
TAX000334
Genes annotated by the GO term GO:0046467. The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. (more detail) 48 NA Homo sapiens
TAX025112
GO:0045454 biological process cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. (more detail) 67 NA Homo sapiens
WIG001535
Aldosterone Signaling in Epithelial Cells Aldosterone Signaling in Epithelial Cells (more detail) 60 NA Homo sapiens
WIG000934
Genes involved in Insulin receptor signalling cascade (more detail) 85 NA Homo sapiens
TAX001230
Genes annotated by the GO term GO:0016298. Catalysis of the hydrolysis of a lipid or phospholipid. (more detail) 50 NA Homo sapiens
TAX019208
GO:0016776 molecular function phosphotransferase activity, phosphate group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate (more detail) 41 NA Homo sapiens
TAX030991
GO:0097747 molecular function RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis (more detail) 41 NA Homo sapiens
TAX022292
GO:0034062 molecular function 5' 3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis (more detail) 41 NA Homo sapiens
TAX032214
GO:1901658 biological process glycosyl compound catabolic process The chemical reactions and pathways resulting in the breakdown of glycosyl compound. (more detail) 41 NA Homo sapiens
TAX015198
GO:0004520 molecular function endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal brea (more detail) 41 NA Homo sapiens
WAG001619
Pentose phosphate pathway The pentose phosphate pathway is a process of glucose turnover that produces DPH as reducing equival (more detail) 41 NA Homo sapiens
TAX001370
Genes annotated by the GO term GO:0004252. Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). (more detail) 41 NA Homo sapiens
MEX001533
Genes associated with Kinase Inhibitor SureCN3470757 Genes associated with Kinase Inhibitor SureCN3470757, curated by the Drug Signature Database (DSigDB (more detail) 41 25990557 Homo sapiens
MEX001356
Genes associated with Kinase Inhibitor Vemurafenib Genes associated with Kinase Inhibitor Vemurafenib, curated by the Drug Signature Database (DSigDB). (more detail) 41 25990557 Homo sapiens
TAX001446
Genes annotated by the GO term GO:0008194. Catalysis of the transfer of a glycosyl group from a UDP sugar to a small hydrophobic molecule. (more detail) 41 NA Homo sapiens
MEX002058
Genes associated with Kinase Inhibitor indirubin deriv. 7a Genes associated with Kinase Inhibitor indirubin deriv. 7a, curated by the Drug Signature Database ( (more detail) 41 25990557 Homo sapiens
MEX002347
Genes associated with Kinase Inhibitor 918505 84 7 Genes associated with Kinase Inhibitor 918505-84-7, curated by the Drug Signature Database (DSigDB). (more detail) 41 25990557 Homo sapiens
WAG001229
Glutamate metabolism (more detail) 41 NA Homo sapiens
WAG001446
beta Alanine metabolism (more detail) 41 NA Homo sapiens
WIG001081
Genes involved in PI Metabolism (more detail) 47 NA Homo sapiens
WIG001512
G Beta Gamma Signaling G-Beta Gamma Signaling (more detail) 66 NA Homo sapiens
TAX023813
GO:0042398 biological process cellular modified amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids (more detail) 44 NA Homo sapiens
TAX023714
GO:0042180 biological process cellular ketone metabolic process The chemical reactions and pathways involving any of a class of organic compounds that contain the c (more detail) 68 NA Homo sapiens
TAX023687
GO:0042133 biological process neurotransmitter metabolic process The chemical reactions and pathways involving neurotransmitters, any of a group of substances that a (more detail) 88 NA Homo sapiens
TAX000028
Genes annotated by the GO term GO:0006520. The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. (more detail) 72 NA Homo sapiens
TAX019531
GO:0018394 biological process peptidyl lysine acetylation The acetylation of peptidyl-lysine. (more detail) 110 NA Homo sapiens
WIG001045
Genes involved in Opioid Signalling (more detail) 76 NA Homo sapiens
WIG001198
Genes involved in Signaling by ERBB2 (more detail) 97 NA Homo sapiens
TAX023850
GO:0042455 biological process ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside i (more detail) 40 NA Homo sapiens
TAX014787
GO:0003755 molecular function peptidyl prolyl cis trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). (more detail) 40 NA Homo sapiens
TAX019274
GO:0016877 molecular function ligase activity, forming carbon sulfur bonds Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis (more detail) 40 NA Homo sapiens
WAG001624
Sphingolipid metabolism (more detail) 40 NA Homo sapiens
WIG000636
Tyrosine metabolism (more detail) 40 NA Homo sapiens
TAX013403
GO:0000413 biological process protein peptidyl prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue. (more detail) 40 NA Homo sapiens
TAX001087
Genes annotated by the GO term GO:0043492. Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance. (more detail) 40 NA Homo sapiens
WAG000390
Alanine and aspartate metabolism (more detail) 40 NA Homo sapiens
WIG000592
Porphyrin and chlorophyll metabolism (more detail) 40 NA Homo sapiens
TAX001199
Genes annotated by the GO term GO:0016798. Catalysis of the hydrolysis of any glycosyl bond. (more detail) 46 NA Homo sapiens
TAX016487
GO:0006635 biological process fatty acid beta oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fa (more detail) 56 NA Homo sapiens
TAX024651
GO:0044264 biological process cellular polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosacchari (more detail) 67 NA Homo sapiens
MEX002155
Genes associated with Kinase Inhibitor AGN PC 04XSIT Genes associated with Kinase Inhibitor AGN-PC-04XSIT, curated by the Drug Signature Database (DSigDB (more detail) 43 25990557 Homo sapiens
WIG001551
Huntington Disease Pathway Huntington Disease Pathway (more detail) 69 NA Homo sapiens
WIG001076
Genes involved in PI3K Cascade (more detail) 69 NA Homo sapiens
FEX000743
Breast Speers09 52genes OverExpressedNegativeCancer Supplementary Table 2: Kinases overexpressed in ER?negative breast cancer (more detail) 51 19808870 Homo sapiens
TAX000186
Genes annotated by the GO term GO:0006118. The transport of electrons from an electron donor to an electron acceptor. (more detail) 51 NA Homo sapiens
TAX031098
GO:0098732 biological process macromolecule deacylation The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, fro (more detail) 73 NA Homo sapiens
WIG000643
VEGF signaling pathway There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelia (more detail) 75 NA Homo sapiens
WIG001429
CCR3 Pathway in Eosinophils CCR3 Pathway in Eosinophils (more detail) 75 NA Homo sapiens
WAG001226
ErbB signaling pathway The ErbB family of receptor tyrosine kises (RTKs) couples binding of extracellular growth factor lig (more detail) 75 NA Homo sapiens
TAX019530
GO:0018393 biological process internal peptidyl lysine acetylation The addition of an acetyl group to a non-terminal lysine residue in a protein. (more detail) 107 NA Homo sapiens
FEX001153
Immune Kong10 5640genes ImmPort ComprehensiveListofImmune RelatedGenes ImmPort Comprehensive List of Immune-Related Genes (more detail) 4375 20460173 Homo sapiens
WIG001672
Signaling in Gap Junctions Signaling in Gap Junctions (more detail) 94 NA Homo sapiens
MEX002404
Genes associated with Kinase Inhibitor Axitinib Genes associated with Kinase Inhibitor Axitinib, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
TAX001194
Genes annotated by the GO term GO:0016820. Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. (more detail) 39 NA Homo sapiens
MEX001905
Genes associated with Kinase Inhibitor Axitinib Genes associated with Kinase Inhibitor Axitinib, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX001839
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX001834
Genes associated with Kinase Inhibitor 722544 51 6 Genes associated with Kinase Inhibitor 722544-51-6, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
WIG000605
Pyruvate metabolism (more detail) 39 NA Homo sapiens
MEX002356
Genes associated with Kinase Inhibitor Dinaciclib Genes associated with Kinase Inhibitor Dinaciclib, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MEX002035
Genes associated with Kinase Inhibitor GSK1838705A Genes associated with Kinase Inhibitor GSK1838705A, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
WIG000555
Lysine degradation (more detail) 39 NA Homo sapiens
TAX013249
GO:0000096 biological process sulfur amino acid metabolic process The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, ho (more detail) 39 NA Homo sapiens
WAG000621
Pentose and glucuronate interconversions (more detail) 39 NA Homo sapiens
TAX025587
GO:0046473 biological process phosphatidic acid metabolic process The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphat (more detail) 39 NA Homo sapiens
TAX016577
GO:0006757 biological process ATP generation from ADP The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. (more detail) 39 NA Homo sapiens
TAX014873
GO:0003954 molecular function NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. (more detail) 39 NA Homo sapiens
TAX017488
GO:0009072 biological process aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic (more detail) 39 NA Homo sapiens
TAX021560
GO:0032451 molecular function demethylase activity Catalysis of the removal of a methyl group from a substrate. (more detail) 39 NA Homo sapiens
TAX027050
GO:0051540 molecular function metal cluster binding Interacting selectively and non-covalently with a cluster of atoms including both metal ions and non (more detail) 64 NA Homo sapiens
TAX027046
GO:0051536 molecular function iron sulfur cluster binding Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and su (more detail) 64 NA Homo sapiens
TAX024752
GO:0044439 cellular component peroxisomal part Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to (more detail) 99 NA Homo sapiens
TAX024751
GO:0044438 cellular component microbody part Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bo (more detail) 99 NA Homo sapiens
WIG001611
p53 Signaling p53 Signaling (more detail) 84 NA Homo sapiens
WIG000873
Genes involved in Glucose metabolism (more detail) 66 NA Homo sapiens
TAX016245
GO:0006304 biological process DNA modification The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its propert (more detail) 82 NA Homo sapiens
TAX022970
GO:0035601 biological process protein deacylation The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, fro (more detail) 72 NA Homo sapiens
FEX000745
Breast Speers09 52genes IDKinasesOverExpressed Table 2. Kinases identified in analysis as most highly overexpressed in ER-negative tumors (more detail) 50 19808870 Homo sapiens
TAX022274
GO:0034030 biological process ribonucleoside bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a c (more detail) 57 NA Homo sapiens
TAX022250
GO:0033866 biological process nucleoside bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compo (more detail) 57 NA Homo sapiens
TAX022277
GO:0034033 biological process purine nucleoside bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, (more detail) 57 NA Homo sapiens
TAX029734
GO:0071897 biological process DNA biosynthetic process The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of (more detail) 102 NA Homo sapiens
TAX016079
GO:0006023 biological process aminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containi (more detail) 102 NA Homo sapiens
IEI014577
Protein protein interactors of human gene UBE2H from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2H (SwissProt ID= (more detail) 87 17535438 Homo sapiens
WIG000633
Tryptophan metabolism (more detail) 38 NA Homo sapiens
MEX002420
Genes associated with Kinase Inhibitor Nilotinib Genes associated with Kinase Inhibitor Nilotinib, curated by the Drug Signature Database (DSigDB). (more detail) 38 25990557 Homo sapiens
WAG000815
ABC transporters The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are (more detail) 38 NA Homo sapiens
WAG000619
Glycerolipid metabolism (more detail) 38 NA Homo sapiens
MEX001100
Genes associated with Approved Drug afatinib Genes associated with Approved Drug afatinib, curated by the Drug Signature Database (DSigDB). (more detail) 38 25990557 Homo sapiens
WAG001435
Lysine degradation (more detail) 38 NA Homo sapiens
MEX001769
Genes associated with Kinase Inhibitor GSK2606414 Genes associated with Kinase Inhibitor GSK2606414, curated by the Drug Signature Database (DSigDB). (more detail) 38 25990557 Homo sapiens
TAX016126
GO:0006096 biological process glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with (more detail) 38 NA Homo sapiens
TAX014838
GO:0003899 molecular function DNA directed 5' 3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA (more detail) 38 NA Homo sapiens
TAX030551
GO:0090503 biological process RNA phosphodiester bond hydrolysis, exonucleolytic The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds (more detail) 38 NA Homo sapiens
TAX028981
GO:0070534 biological process protein K63 linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine (more detail) 38 NA Homo sapiens
TAX026414
GO:0050136 molecular function NADH dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. (more detail) 38 NA Homo sapiens
TAX019003
GO:0016409 molecular function palmitoyltransferase activity Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. (more detail) 38 NA Homo sapiens
TAX016500
GO:0006654 biological process phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative (more detail) 38 NA Homo sapiens
TAX017082
GO:0008137 molecular function NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. (more detail) 38 NA Homo sapiens
TAX030871
GO:0097472 molecular function cyclin dependent protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the rea (more detail) 38 NA Homo sapiens
TAX018644
GO:0015662 molecular function ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 38 NA Homo sapiens
MAX003164
Genes negatively correlated with recurrence free survival in patients with hepatitis B related (HBV) hepatocellular carcinoma (HCC). PURPOSE: The poor prognosis of hepatocellular carcinoma (HCC) is, in part, due to the high rate of r (more detail) 79 NA Homo sapiens
TAX016196
GO:0006221 biological process pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compoun (more detail) 44 NA Homo sapiens
MOX017357
Genes associated with Computational Drug Signature myricetin Genes associated with Computational Drug Signature myricetin, curated by the Drug Signature Database (more detail) 75 25990557 Homo sapiens
TAX017514
GO:0009112 biological process nucleobase metabolic process The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent (more detail) 41 NA Homo sapiens
TAX015928
GO:0005777 cellular component peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxi (more detail) 101 NA Homo sapiens
TAX016080
GO:0006024 biological process glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group (more detail) 101 NA Homo sapiens
TAX030081
GO:0072593 biological process reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions forme (more detail) 99 NA Homo sapiens
TAX016529
GO:0006687 biological process glycosphingolipid metabolic process The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphi (more detail) 58 NA Homo sapiens
WIG000372
MAPKinase Signaling Pathway The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major group (more detail) 86 NA Homo sapiens
TAX000019
Genes annotated by the GO term GO:0006066. The chemical reactions and pathways involving alcohols, any of a class of alkyl compounds containing a hydroxyl group. (more detail) 86 NA Homo sapiens
WIG001487
ErbB4 Pathway ErbB4 Pathway (more detail) 51 NA Homo sapiens
WIG000589
Peroxisome Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. (more detail) 78 NA Homo sapiens
WAG000608
Linoleic acid metabolism (more detail) 37 NA Homo sapiens
FOX000605
Genes in the cancer module 286 (more detail) 37 NA Homo sapiens
TAX001128
Genes annotated by the GO term GO:0004197. Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. (more detail) 37 NA Homo sapiens
MEX001785
Genes associated with Kinase Inhibitor Kinome 1194 Genes associated with Kinase Inhibitor Kinome_1194, curated by the Drug Signature Database (DSigDB). (more detail) 37 25990557 Homo sapiens
MEX002186
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 37 25990557 Homo sapiens
MEX001320
Genes associated with Kinase Inhibitor IKK Inhibitor VII Genes associated with Kinase Inhibitor IKK Inhibitor VII, curated by the Drug Signature Database (DS (more detail) 37 25990557 Homo sapiens
MEX002100
Genes associated with Kinase Inhibitor Nilotinib Genes associated with Kinase Inhibitor Nilotinib, curated by the Drug Signature Database (DSigDB). (more detail) 37 25990557 Homo sapiens
TAX015324
GO:0004693 molecular function cyclin dependent protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein (more detail) 37 NA Homo sapiens
TAX015209
GO:0004532 molecular function exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA mole (more detail) 37 NA Homo sapiens
WIG001654
Antiproliferative Role of SSTR2 Antiproliferative Role of SSTR2 (more detail) 43 NA Homo sapiens
FOX000845
Genes in the cancer module 87 (more detail) 43 NA Homo sapiens
TAX001319
Genes annotated by the GO term GO:0015399. Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. (more detail) 40 NA Homo sapiens
TAX022575
GO:0034637 biological process cellular carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of o (more detail) 48 NA Homo sapiens
TAX017929
GO:0010468 biological process regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the (more detail) 4511 NA Homo sapiens
WIG001413
VEGF Signaling Pathway Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevaci (more detail) 55 NA Homo sapiens
WIG001485
ErbB Family Pathway ErbB Family Pathway (more detail) 63 NA Homo sapiens
MEX001723
Genes associated with Kinase Inhibitor SureCN10127740 Genes associated with Kinase Inhibitor SureCN10127740, curated by the Drug Signature Database (DSigD (more detail) 36 25990557 Homo sapiens
TAX001429
Genes annotated by the GO term GO:0016741. Catalysis of the transfer of a one carbon group from one compound (donor) to another (acceptor). (more detail) 36 NA Homo sapiens
WAG000611
Aminophosphonate metabolism (more detail) 36 NA Homo sapiens
MEX001454
Genes associated with Kinase Inhibitor Quercetagetin Genes associated with Kinase Inhibitor Quercetagetin, curated by the Drug Signature Database (DSigDB (more detail) 36 25990557 Homo sapiens
MEX001590
Genes associated with Kinase Inhibitor BMS 387032 Genes associated with Kinase Inhibitor BMS-387032, curated by the Drug Signature Database (DSigDB). (more detail) 36 25990557 Homo sapiens
WIG000619
Sphingolipid metabolism (more detail) 36 NA Homo sapiens
TAX019287
GO:0016891 molecular function endoribonuclease activity, producing 5' phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks t (more detail) 36 NA Homo sapiens
TAX015090
GO:0004364 molecular function glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromati (more detail) 36 NA Homo sapiens
TAX014909
GO:0004003 molecular function ATP dependent DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DN (more detail) 36 NA Homo sapiens
TAX001305
Genes annotated by the GO term GO:0004620. Catalysis of the hydrolysis of a glycerophospholipid. (more detail) 42 NA Homo sapiens
FOX000438
Genes in the cancer module 109 (more detail) 39 NA Homo sapiens
TAX019328
GO:0017001 biological process antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced b (more detail) 39 NA Homo sapiens
TAX022826
GO:0035337 biological process fatty acyl CoA metabolic process The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in whic (more detail) 39 NA Homo sapiens
MOX017041
Genes associated with Computational Drug Signature ebselen Genes associated with Computational Drug Signature ebselen, curated by the Drug Signature Database ( (more detail) 82 25990557 Homo sapiens
WIG001783
BCR Pathway BCR Pathway (more detail) 93 NA Homo sapiens
TAX016581
GO:0006767 biological process water soluble vitamin metabolic process The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in (more detail) 80 NA Homo sapiens
WIG001722
VEGF and S 1P Signaling VEGF and S-1P Signaling (more detail) 49 NA Homo sapiens
WAG000806
VEGF signaling pathway There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelia (more detail) 60 NA Homo sapiens
MOX013816
Genes associated with Computational Drug Signature myricetin Genes associated with Computational Drug Signature myricetin, curated by the Drug Signature Database (more detail) 62 25990557 Homo sapiens
WIG001479
Ephrin Eph Signaling Ephrin-Eph Signaling (more detail) 66 NA Homo sapiens
TAX001247
Genes annotated by the GO term GO:0008168. Catalysis of the transfer of a methyl group to an acceptor molecule. (more detail) 35 NA Homo sapiens
MEX001512
Genes associated with Kinase Inhibitor Doramapimod Genes associated with Kinase Inhibitor Doramapimod, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX001696
Genes associated with Kinase Inhibitor Ki20227 Genes associated with Kinase Inhibitor Ki20227, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX002126
Genes associated with Kinase Inhibitor 841290 80 0 Genes associated with Kinase Inhibitor 841290-80-0, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
WAG000624
Glycine, serine and threonine metabolism Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD: (more detail) 35 NA Homo sapiens
MEX002398
Genes associated with Kinase Inhibitor Erlotinib Genes associated with Kinase Inhibitor Erlotinib, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX002063
Genes associated with Kinase Inhibitor Erlotinib Genes associated with Kinase Inhibitor Erlotinib, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX002385
Genes associated with Kinase Inhibitor R547 Genes associated with Kinase Inhibitor R547, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MEX001485
Genes associated with Kinase Inhibitor Syk Inhibitor Genes associated with Kinase Inhibitor Syk Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 35 25990557 Homo sapiens
TAX019132
GO:0016620 molecular function oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts (more detail) 35 NA Homo sapiens
TAX016561
GO:0006734 biological process NADH metabolic process The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a co (more detail) 35 NA Homo sapiens
TAX019245
GO:0016831 molecular function carboxy lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. (more detail) 35 NA Homo sapiens
TAX024150
GO:0043094 biological process cellular metabolic compound salvage Any process which produces a useful metabolic compound from derivatives of it without de novo synthe (more detail) 35 NA Homo sapiens
TAX019235
GO:0016814 molecular function hydrolase activity, acting on carbon nitrogen (but not peptide) bonds, in cyclic amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound (more detail) 35 NA Homo sapiens
TAX019169
GO:0016709 molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred (more detail) 35 NA Homo sapiens
TAX017229
GO:0008378 molecular function galactosyltransferase activity Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydr (more detail) 35 NA Homo sapiens
TAX016087
GO:0006040 biological process amino sugar metabolic process The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in p (more detail) 38 NA Homo sapiens
TAX020687
GO:0030880 cellular component RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one (more detail) 55 NA Homo sapiens
TAX000240
Genes annotated by the GO term GO:0009101. The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. (more detail) 73 NA Homo sapiens
IEI014572
Protein protein interactors of human gene UBE2E2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2E2 (SwissProt ID (more detail) 80 17535438 Homo sapiens
TAX024598
GO:0044106 biological process cellular amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character (more detail) 52 NA Homo sapiens
TAX001310
Genes annotated by the GO term GO:0008081. Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. (more detail) 40 NA Homo sapiens
TAX001219
Genes annotated by the GO term GO:0016853. Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. (more detail) 34 NA Homo sapiens
MEX001554
Genes associated with Kinase Inhibitor TAK 715 Genes associated with Kinase Inhibitor TAK-715, curated by the Drug Signature Database (DSigDB). (more detail) 34 25990557 Homo sapiens
MEX002394
Genes associated with Kinase Inhibitor TG100 115 Genes associated with Kinase Inhibitor TG100-115, curated by the Drug Signature Database (DSigDB). (more detail) 34 25990557 Homo sapiens
WIG000488
Butanoate metabolism (more detail) 34 NA Homo sapiens
TAX018441
GO:0015020 molecular function glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. (more detail) 34 NA Homo sapiens
TAX019219
GO:0016790 molecular function thiolester hydrolase activity Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiole (more detail) 34 NA Homo sapiens
TAX017228
GO:0008376 molecular function acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an (more detail) 34 NA Homo sapiens
TAX025764
GO:0046839 biological process phospholipid dephosphorylation The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a gr (more detail) 34 NA Homo sapiens
TAX019657
GO:0019239 molecular function deaminase activity Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). (more detail) 34 NA Homo sapiens
TAX017240
GO:0008395 molecular function steroid hydroxylase activity Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. (more detail) 34 NA Homo sapiens
TAX030040
GO:0072529 biological process pyrimidine containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, (more detail) 34 NA Homo sapiens
WIG001339
Proton Pump Inhibitor Pathway, Pharmacodynamics Genes involved in the proton pump activation and trafficking. (more detail) 45 NA Homo sapiens
TAX001290
Genes annotated by the GO term GO:0016705. Catalysis of an oxidation reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. (more detail) 37 NA Homo sapiens
TAX000137
Genes annotated by the GO term GO:0006732. The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. (more detail) 37 NA Homo sapiens
IEI014581
Protein protein interactors of human gene UBE2K from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2K (SwissProt ID= (more detail) 87 17535438 Homo sapiens
WIG002003
Glycolysis and Gluconeogenesis Glycolysis and Gluconeogenesis (more detail) 47 NA Homo sapiens
WIG001652
Relaxin Pathway Relaxin Pathway (more detail) 62 NA Homo sapiens
TAX029570
GO:0071616 biological process acyl CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzy (more detail) 42 NA Homo sapiens
TAX022853
GO:0035384 biological process thioester biosynthetic process The chemical reactions and pathways resulting in the formation of a thioester, a compound of general (more detail) 42 NA Homo sapiens
WIG001472
EGF Pathway EGF Pathway (more detail) 77 NA Homo sapiens
WEX000055
Lipid Metabolism The genes related to lipid metabolism (metabolism) in tumor, immune, stroma using next-generation se (more detail) 77 NA Homo sapiens
TAX016442
GO:0006576 biological process cellular biogenic amine metabolic process The chemical reactions and pathways occurring at the level of individual cells involving any of a gr (more detail) 51 NA Homo sapiens
TAX025484
GO:0046173 biological process polyol biosynthetic process The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing t (more detail) 39 NA Homo sapiens
TAX000467
Genes annotated by the GO term GO:0008654. The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono or diester. (more detail) 39 NA Homo sapiens
MOX004390
Genes associated with Computational Drug Signature AC1L1I3Y Genes associated with Computational Drug Signature AC1L1I3Y, curated by the Drug Signature Database (more detail) 39 25990557 Homo sapiens
MEX002298
Genes associated with Kinase Inhibitor IPA 3 Genes associated with Kinase Inhibitor IPA-3, curated by the Drug Signature Database (DSigDB). (more detail) 33 25990557 Homo sapiens
WAG001437
Histidine metabolism (more detail) 33 NA Homo sapiens
WIG000950
Genes involved in Ion transport by P type ATPases (more detail) 33 NA Homo sapiens
TAX001352
Genes annotated by the GO term GO:0004702. (more detail) 33 NA Homo sapiens
WAG000386
Aminosugars metabolism (more detail) 33 NA Homo sapiens
MEX002418
Genes associated with Kinase Inhibitor Regorafenib Genes associated with Kinase Inhibitor Regorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 33 25990557 Homo sapiens
TAX025467
GO:0046131 biological process pyrimidine ribonucleoside metabolic process The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine b (more detail) 33 NA Homo sapiens
TAX030893
GO:0097502 biological process mannosylation The covalent attachment of a mannose residue to a substrate molecule. (more detail) 33 NA Homo sapiens
TAX017561
GO:0009164 biological process nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic mol (more detail) 33 NA Homo sapiens
TAX013410
GO:0000428 cellular component DNA directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity. (more detail) 53 NA Homo sapiens
WIG000560
Melanoma Five distinct stages have been proposed in the evolution of melanoma on the basis of histological cr (more detail) 71 NA Homo sapiens
TAX001201
Genes annotated by the GO term GO:0004553. Catalysis of the hydrolysis of any O glycosyl bond. (more detail) 36 NA Homo sapiens
WIG001307
Genes involved in Triglyceride Biosynthesis (more detail) 36 NA Homo sapiens
WIG000883
Genes involved in Glycosphingolipid metabolism (more detail) 36 NA Homo sapiens
WIG000189
Thromboxane A2 receptor signaling (more detail) 55 NA Homo sapiens
WEX000108
VEGF Signaling The genes related to vegf signaling (signaling pathways) in tumor, stroma using next-generation sequ (more detail) 69 NA Homo sapiens
FOX000529
Genes in the cancer module 199 (more detail) 57 NA Homo sapiens
WIG000511
Epithelial cell signaling in Helicobacter pylori infection Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV se (more detail) 67 NA Homo sapiens
TAX000542
Genes annotated by the GO term GO:0030163. The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. (more detail) 65 NA Homo sapiens
TAX025614
GO:0046513 biological process ceramide biosynthetic process The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoi (more detail) 41 NA Homo sapiens
TAX016146
GO:0006120 biological process mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, medi (more detail) 38 NA Homo sapiens
TAX027542
GO:0055029 cellular component nuclear DNA directed RNA polymerase complex A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity. (more detail) 52 NA Homo sapiens
TAX021379
GO:0032200 biological process telomere organization A process that is carried out at the cellular level which results in the assembly, arrangement of co (more detail) 83 NA Homo sapiens
TAX017638
GO:0009261 biological process ribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consi (more detail) 32 NA Homo sapiens
TAX019292
GO:0016896 molecular function exoribonuclease activity, producing 5' phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residu (more detail) 32 NA Homo sapiens
TAX024198
GO:0043171 biological process peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more ( (more detail) 32 NA Homo sapiens
TAX025409
GO:0046039 biological process GTP metabolic process The chemical reactions and pathways involving GTP, guanosine triphosphate. (more detail) 32 NA Homo sapiens
MEX001438
Genes associated with Kinase Inhibitor Ro 3306 Genes associated with Kinase Inhibitor Ro-3306, curated by the Drug Signature Database (DSigDB). (more detail) 32 25990557 Homo sapiens
MEX002328
Genes associated with Kinase Inhibitor SureCN571763 Genes associated with Kinase Inhibitor SureCN571763, curated by the Drug Signature Database (DSigDB) (more detail) 32 25990557 Homo sapiens
TAX001432
Genes annotated by the GO term GO:0016782. Catalysis of the transfer of a sulfur containing group from one compound (donor) to another (acceptor). (more detail) 32 NA Homo sapiens
WAG001614
Bile acid biosynthesis Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile ac (more detail) 32 NA Homo sapiens
WIG000519
Fructose and mannose metabolism (more detail) 32 NA Homo sapiens
WAG000818
Riboflavin metabolism (more detail) 32 NA Homo sapiens
MEX001278
Genes associated with Kinase Inhibitor AGN PC 0INJ9Y Genes associated with Kinase Inhibitor AGN-PC-0INJ9Y, curated by the Drug Signature Database (DSigDB (more detail) 32 25990557 Homo sapiens
FOX000598
Genes in the cancer module 278 (more detail) 32 NA Homo sapiens
WAG000202
Nitrogen metabolism The biological process of the nitrogen cycle is a complex interplay among many microorganisms cataly (more detail) 32 NA Homo sapiens
TAX024454
GO:0043574 biological process peroxisomal transport Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle tha (more detail) 68 NA Homo sapiens
WAG001428
Long term depression Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar l (more detail) 62 NA Homo sapiens
MOX014986
Genes associated with Computational Drug Signature SB 202190 Genes associated with Computational Drug Signature SB 202190, curated by the Drug Signature Database (more detail) 45 25990557 Homo sapiens
TAX029972
GO:0072350 biological process tricarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three (more detail) 40 NA Homo sapiens
MOX012500
Genes associated with Computational Drug Signature ellagic acid Genes associated with Computational Drug Signature ellagic acid, curated by the Drug Signature Datab (more detail) 75 25990557 Homo sapiens
TAX000065
Genes annotated by the GO term GO:0016051. The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. (more detail) 47 NA Homo sapiens
MAX003161
Genes that comprise the proteasome gene module A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genom (more detail) 49 NA Homo sapiens
TAX025585
GO:0046470 biological process phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospho (more detail) 69 NA Homo sapiens
TAX030100
GO:0072662 biological process protein localization to peroxisome A process in which a protein is transported to, or maintained at, a location in a peroxisome. (more detail) 67 NA Homo sapiens
TAX030101
GO:0072663 biological process establishment of protein localization to peroxisome The directed movement of a protein to a specific location in a peroxisome. (more detail) 67 NA Homo sapiens
TAX016481
GO:0006625 biological process protein targeting to peroxisome The process of directing proteins towards the peroxisome, usually using signals contained within the (more detail) 67 NA Homo sapiens
WIG001205
Genes involved in Signaling by FGFR mutants (more detail) 42 NA Homo sapiens
TAX013337
GO:0000271 biological process polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of man (more detail) 37 NA Homo sapiens
TAX000775
Genes annotated by the GO term GO:0006790. The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. (more detail) 37 NA Homo sapiens
WAG001431
Melanoma Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western popu (more detail) 65 NA Homo sapiens
WAG001216
Base excision repair Base excision repair (BER) is the predomint D damage repair pathway for the processing of small base (more detail) 31 NA Homo sapiens
TAX017552
GO:0009154 biological process purine ribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compoun (more detail) 31 NA Homo sapiens
WIG000526
Glycine, serine and threonine metabolism Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis , and glycine is derived (more detail) 31 NA Homo sapiens
MEX001412
Genes associated with Kinase Inhibitor Tyrphostin AG 1478 Genes associated with Kinase Inhibitor Tyrphostin AG 1478, curated by the Drug Signature Database (D (more detail) 31 25990557 Homo sapiens
WIG002043
TCA Cycle TCA Cycle (more detail) 31 NA Homo sapiens
FEX002831
StemCell Gillet04 57genes Table 2 Possible chemotherapy substrates of ABC transporters as determined by COMPARE analysis of mi (more detail) 31 15604263 Homo sapiens
TAX019011
GO:0016417 molecular function S acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. (more detail) 31 NA Homo sapiens
WIG000598
Propanoate metabolism (more detail) 31 NA Homo sapiens
TAX001105
Genes annotated by the GO term GO:0016835. Catalysis of the breakage of a carbon oxygen bond. (more detail) 31 NA Homo sapiens
MEX002019
Genes associated with Kinase Inhibitor Canertinib Genes associated with Kinase Inhibitor Canertinib, curated by the Drug Signature Database (DSigDB). (more detail) 31 25990557 Homo sapiens
MEX001223
Genes associated with Kinase Inhibitor NVP TAE684 Genes associated with Kinase Inhibitor NVP-TAE684, curated by the Drug Signature Database (DSigDB). (more detail) 31 25990557 Homo sapiens
WIG001115
Genes involved in Purine metabolism (more detail) 31 NA Homo sapiens
FOX000551
Genes in the cancer module 22 (more detail) 34 NA Homo sapiens
WIG001219
Genes involved in Signaling by SCF KIT (more detail) 76 NA Homo sapiens
TAX025042
GO:0045271 cellular component respiratory chain complex I Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptid (more detail) 44 NA Homo sapiens
TAX015903
GO:0005747 cellular component mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial r (more detail) 44 NA Homo sapiens
TAX020739
GO:0030964 cellular component NADH dehydrogenase complex An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the (more detail) 44 NA Homo sapiens
TAX017485
GO:0009069 biological process serine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, (more detail) 39 NA Homo sapiens
WEX000061
Melanoma The genes related to melanoma (physiology & disease) in tumor using next-generation sequencer (NGS) (more detail) 70 NA Homo sapiens
WIG001610
Androgen Signaling Androgen Signaling (more detail) 66 NA Homo sapiens
WIG001071
Genes involved in Phospholipase C mediated cascade (more detail) 52 NA Homo sapiens
WIG001718
UVA Induced MAPK Signaling UVA-Induced MAPK Signaling (more detail) 41 NA Homo sapiens
WEX000007
Autophagy The genes related to autophagy (cell function) in tumor using next-generation sequencer (NGS) readou (more detail) 62 NA Homo sapiens
TAX016358
GO:0006476 biological process protein deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from ac (more detail) 62 NA Homo sapiens
TAX016130
GO:0006101 biological process citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrat (more detail) 36 NA Homo sapiens
TAX000093
Genes annotated by the GO term GO:0044257. The chemical reactions and pathways resulting in the breakdown of a protein by individual cells. (more detail) 54 NA Homo sapiens
MAX003008
DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites. Zinc-finger protein 143 (ZNF143) is a human homolog of Xenopus transcriptional activator staf that i (more detail) 56 NA Homo sapiens
MEX001409
Genes associated with Kinase Inhibitor PP242 Genes associated with Kinase Inhibitor PP242, curated by the Drug Signature Database (DSigDB). (more detail) 30 25990557 Homo sapiens
TAX001425
Genes annotated by the GO term GO:0016765. Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). (more detail) 30 NA Homo sapiens
WIG001255
Genes involved in Synthesis of PIPs at the plasma membrane (more detail) 30 NA Homo sapiens
TAX013292
GO:0000175 molecular function 3' 5' exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. (more detail) 30 NA Homo sapiens
WAG000406
Nucleotide sugars metabolism (more detail) 30 NA Homo sapiens
TAX001160
Genes annotated by the GO term GO:0008238. Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. (more detail) 30 NA Homo sapiens
MEX002386
Genes associated with Kinase Inhibitor GW843682X Genes associated with Kinase Inhibitor GW843682X, curated by the Drug Signature Database (DSigDB). (more detail) 30 25990557 Homo sapiens
MEX001287
Genes associated with Kinase Inhibitor BI 2536 Genes associated with Kinase Inhibitor BI 2536, curated by the Drug Signature Database (DSigDB). (more detail) 30 25990557 Homo sapiens
PEX001394
Y phosphatase: Protein tyrosine phosphatase (more detail) 30 NA Homo sapiens
MEX001663
Genes associated with Kinase Inhibitor RAF265 Genes associated with Kinase Inhibitor RAF265, curated by the Drug Signature Database (DSigDB). (more detail) 30 25990557 Homo sapiens
MEX001395
Genes associated with Kinase Inhibitor Indirubin Derivative E804 Genes associated with Kinase Inhibitor Indirubin Derivative E804, curated by the Drug Signature Data (more detail) 30 25990557 Homo sapiens
WAG001442
Propanoate metabolism (more detail) 30 NA Homo sapiens
WIG000465
Alanine, aspartate and glutamate metabolism (more detail) 30 NA Homo sapiens
MEX002110
Genes associated with Kinase Inhibitor AGN PC 0HSSYL Genes associated with Kinase Inhibitor AGN-PC-0HSSYL, curated by the Drug Signature Database (DSigDB (more detail) 30 25990557 Homo sapiens
FAX003057
GSEA KEGG Lung Cancer Tissue Explants (Extracellular Vesicles) Purine Metabolism Top 3 KEGG pathways enriched in lung cancer tissue extract extracellular vesicle particles compared (more detail) 30 32795414 Homo sapiens
TAX028527
GO:0061650 molecular function ubiquitin like protein conjugating enzyme activity Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction (more detail) 30 NA Homo sapiens
TAX027493
GO:0052866 molecular function phosphatidylinositol phosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate( (more detail) 30 NA Homo sapiens
TAX022779
GO:0035250 molecular function UDP galactosyltransferase activity Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. (more detail) 30 NA Homo sapiens
TAX019275
GO:0016878 molecular function acid thiol ligase activity Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydro (more detail) 30 NA Homo sapiens
TAX030597
GO:0090662 biological process ATP hydrolysis coupled transmembrane transport The transport of molecules across a membrane and against an electrochemical gradient, using energy f (more detail) 30 NA Homo sapiens
TAX015275
GO:0004623 molecular function phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. (more detail) 30 NA Homo sapiens
TAX016564
GO:0006739 biological process NADP metabolic process The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzym (more detail) 30 NA Homo sapiens
TAX016745
GO:0007031 biological process peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of co (more detail) 73 NA Homo sapiens
TAX001106
Genes annotated by the GO term GO:0004091. Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. (more detail) 33 NA Homo sapiens
TAX017639
GO:0009262 biological process deoxyribonucleotide metabolic process The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyr (more detail) 33 NA Homo sapiens
TAX015961
GO:0005834 cellular component heterotrimeric G protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily (more detail) 33 NA Homo sapiens
TAX033895
GO:1905360 cellular component GTPase complex A protein complex which is capable of GTPase activity. (more detail) 33 NA Homo sapiens
TAX016364
GO:0006482 biological process protein demethylation The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by (more detail) 33 NA Homo sapiens
TAX017134
GO:0008214 biological process protein dealkylation The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an (more detail) 33 NA Homo sapiens
WIG001683
Sweet Taste Signaling Sweet Taste Signaling (more detail) 43 NA Homo sapiens
WIG000191
Signaling events mediated by VEGFR1 and VEGFR2 (more detail) 69 NA Homo sapiens
WIG001780
BAD Phosphorylation BAD Phosphorylation (more detail) 69 NA Homo sapiens
TAX025479
GO:0046164 biological process alcohol catabolic process The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compou (more detail) 47 NA Homo sapiens
TAX014759
GO:0003684 molecular function damaged DNA binding Interacting selectively and non-covalently with damaged DNA. (more detail) 65 NA Homo sapiens
WIG000047
Endothelins (more detail) 63 NA Homo sapiens
WIG001613
PACAP Signaling PACAP Signaling (more detail) 53 NA Homo sapiens
MOX014711
Genes associated with Computational Drug Signature quercetin Genes associated with Computational Drug Signature quercetin, curated by the Drug Signature Database (more detail) 57 25990557 Homo sapiens
WIG001737
Melatonin Signaling Melatonin Signaling (more detail) 55 NA Homo sapiens
WIG001478
EphB EphrinB Signaling EphB-EphrinB Signaling (more detail) 55 NA Homo sapiens
WIG000484
Base excision repair Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small (more detail) 35 NA Homo sapiens
TAX022216
GO:0033692 biological process cellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (more detail) 35 NA Homo sapiens
TAX017793
GO:0009889 biological process regulation of biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resu (more detail) 4286 NA Homo sapiens
TAX021561
GO:0032452 molecular function histone demethylase activity Catalysis of the removal of a methyl group from a histone. (more detail) 29 NA Homo sapiens
TAX018919
GO:0016229 molecular function steroid dehydrogenase activity Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. (more detail) 29 NA Homo sapiens
TAX017490
GO:0009074 biological process aromatic amino acid family catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino (more detail) 29 NA Homo sapiens
TAX019005
GO:0016411 molecular function acylglycerol O acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. (more detail) 29 NA Homo sapiens
TAX029291
GO:0071108 biological process protein K48 linked deubiquitination A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquiti (more detail) 29 NA Homo sapiens
TAX017105
GO:0008175 molecular function tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. (more detail) 29 NA Homo sapiens
MEX001410
Genes associated with Kinase Inhibitor NG25 Genes associated with Kinase Inhibitor NG25, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
MEX002250
Genes associated with Kinase Inhibitor BI D1870 Genes associated with Kinase Inhibitor BI-D1870, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
MEX002028
Genes associated with Kinase Inhibitor CHEMBL1673039 Genes associated with Kinase Inhibitor CHEMBL1673039, curated by the Drug Signature Database (DSigDB (more detail) 29 25990557 Homo sapiens
FOX000553
Genes in the cancer module 221 (more detail) 29 NA Homo sapiens
WAG000197
Biosynthesis of steroids (more detail) 29 NA Homo sapiens
MEX002239
Genes associated with Kinase Inhibitor Kinome 635 Genes associated with Kinase Inhibitor Kinome_635, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
MEX001589
Genes associated with Kinase Inhibitor dorsomorphin Genes associated with Kinase Inhibitor dorsomorphin, curated by the Drug Signature Database (DSigDB) (more detail) 29 25990557 Homo sapiens
WAG000987
Cyanoamino acid metabolism (more detail) 29 NA Homo sapiens
PEX001905
UQ con: Ubiquitin conjugating enzyme Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows c (more detail) 29 NA Homo sapiens
MEX001623
Genes associated with Kinase Inhibitor AT7519 Genes associated with Kinase Inhibitor AT7519, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
TAX000556
Genes annotated by the GO term GO:0032446. A process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin like protein, are covalently attached to a target protein. (more detail) 42 NA Homo sapiens
TAX016129
GO:0006099 biological process tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively o (more detail) 32 NA Homo sapiens
WIG000553
Long term depression Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar l (more detail) 68 NA Homo sapiens
WIG001291
Genes involved in Transcription coupled NER (TC NER) (more detail) 44 NA Homo sapiens
FOX000601
Genes in the cancer module 280 (more detail) 44 NA Homo sapiens
TAX020432
GO:0030286 cellular component dynein complex Any of several large complexes that contain two or three dynein heavy chains and several light chain (more detail) 44 NA Homo sapiens
WIG001591
NGF Pathway NGF Pathway (more detail) 64 NA Homo sapiens
TAX000238
Genes annotated by the GO term GO:0006650. The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O acyl, O alkyl, or O alkenyl group attached to the glycerol residue. (more detail) 46 NA Homo sapiens
TAX019101
GO:0016575 biological process histone deacetylation The modification of histones by removal of acetyl groups. (more detail) 60 NA Homo sapiens
FEX003254
Stomach Bonelli10 61genes Table 4 Functional grouping of genes that were upregulated and downregulated after ibuprofen treatme (more detail) 60 20548326 Homo sapiens
TAX000561
Genes annotated by the GO term GO:0016485. The posttranslational modification of a protein, particularly secretory proteins and proteins targeted for membranes or specific cellular locations. (more detail) 48 NA Homo sapiens
WEX000065
Mitochondrial Metabolism / TCA The genes related to mitochondrial metabolism / tca (metabolism) in tumor, immune, stroma using next (more detail) 52 NA Homo sapiens
WIG001080
Genes involved in PI 3K cascade (more detail) 54 NA Homo sapiens
TAX019485
GO:0018196 biological process peptidyl asparagine modification The modification of peptidyl-asparagine. (more detail) 39 NA Homo sapiens
MOX014987
Genes associated with Computational Drug Signature SB 203580 Genes associated with Computational Drug Signature SB 203580, curated by the Drug Signature Database (more detail) 34 25990557 Homo sapiens
WIG000500
Cysteine and methionine metabolism Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine throu (more detail) 34 NA Homo sapiens
WIG001121
Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle (more detail) 41 NA Homo sapiens
TAX015276
GO:0004629 molecular function phospholipase C activity Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. (more detail) 28 NA Homo sapiens
TAX025470
GO:0046134 biological process pyrimidine nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of one of a family of organic molecul (more detail) 28 NA Homo sapiens
TAX028519
GO:0061631 molecular function ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y (more detail) 28 NA Homo sapiens
TAX023721
GO:0042219 biological process cellular modified amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids (more detail) 28 NA Homo sapiens
TAX015317
GO:0004683 molecular function calmodulin dependent protein kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a pro (more detail) 28 NA Homo sapiens
TAX031322
GO:0099131 biological process ATP hydrolysis coupled ion transmembrane transport The transport of an inorganic ion across a membrane and against an electrochemical gradient, using e (more detail) 28 NA Homo sapiens
TAX015031
GO:0004181 molecular function metallocarboxypeptidase activity Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanis (more detail) 28 NA Homo sapiens
TAX024836
GO:0044769 molecular function ATPase activity, coupled to transmembrane movement of ions, rotational mechanism Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP (more detail) 28 NA Homo sapiens
MEX001261
Genes associated with Kinase Inhibitor Torin 1 Genes associated with Kinase Inhibitor Torin 1, curated by the Drug Signature Database (DSigDB). (more detail) 28 25990557 Homo sapiens
TAX001408
Genes annotated by the GO term GO:0008146. Catalysis of the transfer of a sulfate group from 3' phosphoadenosine 5' phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3' phosphoadenosine 5' phosphate. (more detail) 28 NA Homo sapiens
FOX000621
Genes in the cancer module 303 (more detail) 28 NA Homo sapiens
MEX001704
Genes associated with Kinase Inhibitor ITK inhibitor Genes associated with Kinase Inhibitor ITK inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 28 25990557 Homo sapiens
MEX001110
Genes associated with Approved Drug pazopanib hydrochloride Genes associated with Approved Drug pazopanib hydrochloride, curated by the Drug Signature Database (more detail) 28 25990557 Homo sapiens
MEX002007
Genes associated with Kinase Inhibitor GSK 650394 Genes associated with Kinase Inhibitor GSK 650394, curated by the Drug Signature Database (DSigDB). (more detail) 28 25990557 Homo sapiens
FOX000834
Genes in the cancer module 77 (more detail) 28 NA Homo sapiens
FOX000516
Genes in the cancer module 184 (more detail) 28 NA Homo sapiens
WIG000615
RNA polymerase (more detail) 28 NA Homo sapiens
TAX001252
Genes annotated by the GO term GO:0004497. Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. (more detail) 31 NA Homo sapiens
WIG000133
Regulation of p38 alpha and p38 beta (more detail) 31 NA Homo sapiens
WIG000497
Citrate cycle (TCA cycle) The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of th (more detail) 31 NA Homo sapiens
TAX019103
GO:0016577 biological process histone demethylation The modification of histones by removal of methyl groups. (more detail) 31 NA Homo sapiens
TAX019778
GO:0019692 biological process deoxyribose phosphate metabolic process The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deox (more detail) 31 NA Homo sapiens
WIG001498
Fc EpsilonRI Pathway Fc-EpsilonRI Pathway (more detail) 63 NA Homo sapiens
WIG000850
Genes involved in FRS2 mediated cascade (more detail) 36 NA Homo sapiens
WAG000800
Epithelial cell signaling in Helicobacter pylori infection Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV se (more detail) 59 NA Homo sapiens
TAX000811
Genes annotated by the GO term GO:0006512. The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein. (more detail) 47 NA Homo sapiens
FEX002545
pancreas Miyake06 52genes Table 1 Fifty-two genes were examined using customized cDNA array (more detail) 49 16699793 Homo sapiens
IEI014277
Protein protein interactors of human gene TRIM8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM8 (SwissProt ID= (more detail) 51 17535438 Homo sapiens
TAX016083
GO:0006029 biological process proteoglycan metabolic process The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydr (more detail) 51 NA Homo sapiens
MOX012473
Genes associated with Computational Drug Signature ebselen Genes associated with Computational Drug Signature ebselen, curated by the Drug Signature Database ( (more detail) 68 25990557 Homo sapiens
TAX019510
GO:0018279 biological process protein N linked glycosylation via asparagine The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine (more detail) 38 NA Homo sapiens
WIG001428
CCKBR Gastrin Stimulated Signaling CCKBR-Gastrin Stimulated Signaling (more detail) 66 NA Homo sapiens
TAX024125
GO:0043038 biological process amino acid activation The modification of an amino acid to an active form, for incorporation into a peptide, protein or ot (more detail) 33 NA Homo sapiens
WIG001502
Fc GammaR Mediated Phagocytosis in Macrophages Fc-GammaR-Mediated Phagocytosis in Macrophages (more detail) 64 NA Homo sapiens
TAX018811
GO:0015988 biological process energy coupled proton transmembrane transport, against electrochemical gradient The transport of protons across a membrane and against an electrochemical gradient, using energy fro (more detail) 27 NA Homo sapiens
TAX019164
GO:0016701 molecular function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred (more detail) 27 NA Homo sapiens
TAX018813
GO:0015991 biological process ATP hydrolysis coupled proton transport The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis. (more detail) 27 NA Homo sapiens
TAX022230
GO:0033764 molecular function steroid dehydrogenase activity, acting on the CH OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or el (more detail) 27 NA Homo sapiens
TAX001092
Genes annotated by the GO term GO:0008026. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. (more detail) 27 NA Homo sapiens
WIG001386
Sorafenib Pharmacodynamics Mechanism of action of sorafenib (more detail) 27 NA Homo sapiens
TAX001202
Genes annotated by the GO term GO:0016836. Catalysis of the cleavage of a carbon oxygen bond by elimination of water. (more detail) 27 NA Homo sapiens
MEX001616
Genes associated with Kinase Inhibitor AGN PC 087NKJ Genes associated with Kinase Inhibitor AGN-PC-087NKJ, curated by the Drug Signature Database (DSigDB (more detail) 27 25990557 Homo sapiens
MEX001642
Genes associated with Kinase Inhibitor AGN PC 04T5ZK Genes associated with Kinase Inhibitor AGN-PC-04T5ZK, curated by the Drug Signature Database (DSigDB (more detail) 27 25990557 Homo sapiens
TAX022548
GO:0034593 molecular function phosphatidylinositol bisphosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate (more detail) 27 NA Homo sapiens
FEX000284
Breast Bieche04 27genes Table 2. Target genes tested; 27 xenobiotic-metabolizing target genes the ESR1/ERalpha gene (coding (more detail) 27 15084249 Homo sapiens
WIG000587
Pentose and glucuronate interconversions (more detail) 27 NA Homo sapiens
MEX002246
Genes associated with Kinase Inhibitor Bosutinib Genes associated with Kinase Inhibitor Bosutinib, curated by the Drug Signature Database (DSigDB). (more detail) 27 25990557 Homo sapiens
WAG001003
Phenylalanine, tyrosine and tryptophan biosynthesis (more detail) 27 NA Homo sapiens
TAX019782
GO:0019706 molecular function protein cysteine S palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecul (more detail) 27 NA Homo sapiens
TAX019783
GO:0019707 molecular function protein cysteine S acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule. (more detail) 27 NA Homo sapiens
TAX019171
GO:0016712 molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred (more detail) 27 NA Homo sapiens
WIG000541
Histidine metabolism (more detail) 27 NA Homo sapiens
WAG000996
Glycan structures degradation (more detail) 27 NA Homo sapiens
TAX014836
GO:0003887 molecular function DNA directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synth (more detail) 27 NA Homo sapiens
TAX025826
GO:0046949 biological process fatty acyl CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative o (more detail) 30 NA Homo sapiens
WAG000805
Selenoamino acid metabolism (more detail) 30 NA Homo sapiens
WAG000998
Arginine and proline metabolism (more detail) 30 NA Homo sapiens
TAX016383
GO:0006513 biological process protein monoubiquitination Addition of a single ubiquitin group to a protein. (more detail) 60 NA Homo sapiens
TAX000717
Genes annotated by the GO term GO:0006979. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. (more detail) 44 NA Homo sapiens
WIG000895
Genes involved in G alpha (z) signalling events (more detail) 44 NA Homo sapiens
TAX025540
GO:0046364 biological process monosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcoho (more detail) 54 NA Homo sapiens
TAX013230
GO:0000049 molecular function tRNA binding Interacting selectively and non-covalently with transfer RNA. (more detail) 48 NA Homo sapiens
MOX012175
Genes associated with Computational Drug Signature Dasatinib Genes associated with Computational Drug Signature Dasatinib, curated by the Drug Signature Database (more detail) 50 25990557 Homo sapiens
TAX019794
GO:0019748 biological process secondary metabolic process The chemical reactions and pathways resulting in many of the chemical changes of compounds that are (more detail) 50 NA Homo sapiens
WIG001917
TSH signaling pathway TSH signaling pathway (more detail) 65 NA Homo sapiens
WIG001014
Genes involved in Negative regulation of FGFR signaling (more detail) 37 NA Homo sapiens
TAX020569
GO:0030574 biological process collagen catabolic process The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extrac (more detail) 37 NA Homo sapiens
TAX017675
GO:0009395 biological process phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containin (more detail) 32 NA Homo sapiens
TAX024126
GO:0043039 biological process tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their correspo (more detail) 32 NA Homo sapiens
TAX020524
GO:0030488 biological process tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. (more detail) 32 NA Homo sapiens
MAX001954
Genes involved in gluconeogenesis; based on literature and sequence annotation resources and converted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 32 NA Homo sapiens
TAX023844
GO:0042446 biological process hormone biosynthetic process The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring s (more detail) 61 NA Homo sapiens
TAX000570
Genes annotated by the GO term GO:0016567. The process by which one or more ubiquitin moieties are added to a protein. (more detail) 39 NA Homo sapiens
TAX027049
GO:0051539 molecular function 4 iron, 4 sulfur cluster binding Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster co (more detail) 41 NA Homo sapiens
TAX015130
GO:0004435 molecular function phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglyce (more detail) 26 NA Homo sapiens
TAX028507
GO:0061615 biological process glycolytic process through fructose 6 phosphate The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, oc (more detail) 26 NA Homo sapiens
TAX028678
GO:0070001 molecular function aspartic type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water (more detail) 26 NA Homo sapiens
TAX018999
GO:0016405 molecular function CoA ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. (more detail) 26 NA Homo sapiens
TAX019143
GO:0016645 molecular function oxidoreductase activity, acting on the CH NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or el (more detail) 26 NA Homo sapiens
TAX025582
GO:0046466 biological process membrane lipid catabolic process The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found i (more detail) 26 NA Homo sapiens
TAX015335
GO:0004709 molecular function MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can b (more detail) 26 NA Homo sapiens
TAX019136
GO:0016628 molecular function oxidoreductase activity, acting on the CH CH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or el (more detail) 26 NA Homo sapiens
TAX028509
GO:0061620 biological process glycolytic process through glucose 6 phosphate The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occu (more detail) 26 NA Homo sapiens
TAX019165
GO:0016702 molecular function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred (more detail) 26 NA Homo sapiens
TAX017481
GO:0009065 biological process glutamine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine famil (more detail) 26 NA Homo sapiens
TAX014869
GO:0003950 molecular function NAD+ ADP ribosyltransferase activity Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)- (more detail) 26 NA Homo sapiens
TAX014929
GO:0004033 molecular function aldo keto reductase (NADP) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. (more detail) 26 NA Homo sapiens
TAX029006
GO:0070566 molecular function adenylyltransferase activity Catalysis of the transfer of an adenylyl group to an acceptor. (more detail) 26 NA Homo sapiens
WAG000821
Urea cycle and metabolism of amino groups (more detail) 26 NA Homo sapiens
WAG000377
Ether lipid metabolism (more detail) 26 NA Homo sapiens
WIG000588
Pentose phosphate pathway The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equiv (more detail) 26 NA Homo sapiens
WIG000580
O Glycan biosynthesis O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis (more detail) 26 NA Homo sapiens
MEX002158
Genes associated with Kinase Inhibitor Enzastaurin Genes associated with Kinase Inhibitor Enzastaurin, curated by the Drug Signature Database (DSigDB). (more detail) 26 25990557 Homo sapiens
MEX002195
Genes associated with Kinase Inhibitor BX 912 Genes associated with Kinase Inhibitor BX-912, curated by the Drug Signature Database (DSigDB). (more detail) 26 25990557 Homo sapiens
WAG000817
Pantothenate and CoA biosynthesis (more detail) 26 NA Homo sapiens
MEX002214
Genes associated with Kinase Inhibitor 3ztx Genes associated with Kinase Inhibitor 3ztx, curated by the Drug Signature Database (DSigDB). (more detail) 26 25990557 Homo sapiens
WIG000520
Galactose metabolism (more detail) 26 NA Homo sapiens
MEX002192
Genes associated with Kinase Inhibitor ILORASERTIB Genes associated with Kinase Inhibitor ILORASERTIB, curated by the Drug Signature Database (DSigDB). (more detail) 26 25990557 Homo sapiens
WIG000529
Glycosaminoglycan biosynthesis heparan sulfate (more detail) 26 NA Homo sapiens
TAX017674
GO:0009394 biological process 2' deoxyribonucleotide metabolic process The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'- (more detail) 29 NA Homo sapiens
MOX007315
Genes associated with Computational Drug Signature bisindolylmaleimide iv Genes associated with Computational Drug Signature bisindolylmaleimide iv, curated by the Drug Signa (more detail) 29 25990557 Homo sapiens
PEX000431
DSPc: Dual specificity phosphatase, catalytic domain Ser/Thr and Tyr protein phosphatases. The enzymes tertiary fold is highly similar to that of tyrosin (more detail) 29 NA Homo sapiens
TAX013226
GO:0000038 biological process very long chain fatty acid metabolic process The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22 (more detail) 29 NA Homo sapiens
TAX000426
Genes annotated by the GO term GO:0044270. The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. (more detail) 29 NA Homo sapiens
TAX001178
Genes annotated by the GO term GO:0019001. Interacting selectively with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. (more detail) 45 NA Homo sapiens
FOX000843
Genes in the cancer module 85 (more detail) 51 NA Homo sapiens
WIG001039
Genes involved in Nucleotide Excision Repair (more detail) 49 NA Homo sapiens
TAX000436
Genes annotated by the GO term GO:0055086. The chemical reactions and pathways involving nucleobases, nucleosides and nucleotides. (more detail) 49 NA Homo sapiens
TAX025572
GO:0046456 biological process icosanoid biosynthetic process The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 (more detail) 36 NA Homo sapiens
TAX017616
GO:0009225 biological process nucleotide sugar metabolic process The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrat (more detail) 31 NA Homo sapiens
MOX015675
Genes associated with Computational Drug Signature U 0126 Genes associated with Computational Drug Signature U-0126, curated by the Drug Signature Database (D (more detail) 31 25990557 Homo sapiens
TAX000465
Genes annotated by the GO term GO:0030384. The chemical reactions and pathways involving phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. They are important constituents of cell membranes. (more detail) 31 NA Homo sapiens
TAX021908
GO:0032981 biological process mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respi (more detail) 58 NA Homo sapiens
TAX017885
GO:0010257 biological process NADH dehydrogenase complex assembly The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogena (more detail) 58 NA Homo sapiens
TAX019306
GO:0016925 biological process protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target pro (more detail) 38 NA Homo sapiens
WIG000138
p53 pathway (more detail) 56 NA Homo sapiens
TAX021931
GO:0033013 biological process tetrapyrrole metabolic process The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrol (more detail) 54 NA Homo sapiens
TAX028715
GO:0070076 biological process histone lysine demethylation The modification of a histone by the removal of a methyl group from a lysine residue. (more detail) 28 NA Homo sapiens
WIG000728
Genes involved in Biosynthesis of the N glycan precursor (dolichol lipid linked oligosaccharide, LLO) and transfer to a nascent protein (more detail) 28 NA Homo sapiens
WIG000899
Genes involved in G protein beta:gamma signalling (more detail) 28 NA Homo sapiens
TAX001256
Genes annotated by the GO term GO:0003774. Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. (more detail) 28 NA Homo sapiens
TAX024579
GO:0044042 biological process glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose re (more detail) 50 NA Homo sapiens
TAX016115
GO:0006073 biological process cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose re (more detail) 50 NA Homo sapiens
FOX000656
Genes in the cancer module 343 (more detail) 25 NA Homo sapiens
WIG001249
Genes involved in Synthesis of PA (more detail) 25 NA Homo sapiens
WIG000478
Ascorbate and aldarate metabolism (more detail) 25 NA Homo sapiens
MEX001658
Genes associated with Kinase Inhibitor GW768505A Genes associated with Kinase Inhibitor GW768505A, curated by the Drug Signature Database (DSigDB). (more detail) 25 25990557 Homo sapiens
FOX000623
Genes in the cancer module 306 (more detail) 25 NA Homo sapiens
FOX000624
Genes in the cancer module 307 (more detail) 25 NA Homo sapiens
TAX013221
GO:0000030 molecular function mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrat (more detail) 25 NA Homo sapiens
FOX000716
Genes in the cancer module 42 (more detail) 25 NA Homo sapiens
TAX001282
Genes annotated by the GO term GO:0016651. Catalysis of an oxidation reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. (more detail) 25 NA Homo sapiens
FOX000467
Genes in the cancer module 135 (more detail) 25 NA Homo sapiens
TAX000025
Genes annotated by the GO term GO:0009063. The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. (more detail) 25 NA Homo sapiens
WIG000534
Glycosphingolipid biosynthesis lacto and neolacto series (more detail) 25 NA Homo sapiens
MEX002062
Genes associated with Kinase Inhibitor Crenolanib Genes associated with Kinase Inhibitor Crenolanib, curated by the Drug Signature Database (DSigDB). (more detail) 25 25990557 Homo sapiens
TAX001356
Genes annotated by the GO term GO:0004540. Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. (more detail) 25 NA Homo sapiens
TAX001143
Genes annotated by the GO term GO:0003678. Catalysis of the unwinding of a DNA duplex. (more detail) 25 NA Homo sapiens
TAX028510
GO:0061621 biological process canonical glycolysis The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokin (more detail) 25 NA Homo sapiens
TAX015033
GO:0004190 molecular function aspartic type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 25 NA Homo sapiens
TAX019269
GO:0016866 molecular function intramolecular transferase activity Catalysis of the transfer of a functional group from one position to another within a single molecul (more detail) 25 NA Homo sapiens
TAX022825
GO:0035336 biological process long chain fatty acyl CoA metabolic process The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme (more detail) 25 NA Homo sapiens
TAX026415
GO:0050145 molecular function nucleoside monophosphate kinase activity Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. (more detail) 25 NA Homo sapiens
TAX014985
GO:0004112 molecular function cyclic nucleotide phosphodiesterase activity Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. (more detail) 25 NA Homo sapiens
TAX028556
GO:0061718 biological process glucose catabolic process to pyruvate The chemical reactions and pathways resulting in the breakdown of glucose, with the production of py (more detail) 25 NA Homo sapiens
TAX019159
GO:0016675 molecular function oxidoreductase activity, acting on a heme group of donors Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or ele (more detail) 25 NA Homo sapiens
TAX018445
GO:0015035 molecular function protein disulfide oxidoreductase activity Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide (more detail) 25 NA Homo sapiens
TAX016562
GO:0006735 biological process NADH regeneration A metabolic process that generates a pool of NADH by the reduction of NAD+. (more detail) 25 NA Homo sapiens
TAX001177
Genes annotated by the GO term GO:0005525. Interacting selectively with GTP, guanosine triphosphate. (more detail) 44 NA Homo sapiens
FOX000584
Genes in the cancer module 259 (more detail) 46 NA Homo sapiens
TAX018880
GO:0016126 biological process sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more (more detail) 46 NA Homo sapiens
TAX020194
GO:0022617 biological process extracellular matrix disassembly A process that results in the breakdown of the extracellular matrix. (more detail) 59 NA Homo sapiens
WIG001714
TRKA Signaling TRKA Signaling (more detail) 59 NA Homo sapiens
TAX000085
Genes annotated by the GO term GO:0044242. The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. (more detail) 35 NA Homo sapiens
MOX016792
Genes associated with Computational Drug Signature nadide Genes associated with Computational Drug Signature nadide, curated by the Drug Signature Database (D (more detail) 57 25990557 Homo sapiens
WIG001766
LPS Stimulated MAPK Signaling LPS Stimulated MAPK Signaling (more detail) 55 NA Homo sapiens
TAX024657
GO:0044273 biological process sulfur compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, suc (more detail) 55 NA Homo sapiens
TAX023903
GO:0042572 biological process retinol metabolic process The chemical reactions and pathways involving retinol, one of the three compounds that makes up vita (more detail) 30 NA Homo sapiens
TAX016533
GO:0006691 biological process leukotriene metabolic process The chemical reactions and pathways involving leukotriene, a pharmacologically active substance deri (more detail) 30 NA Homo sapiens
TAX016403
GO:0006536 biological process glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. (more detail) 30 NA Homo sapiens
WIG000513
Ether lipid metabolism (more detail) 30 NA Homo sapiens
TAX000237
Genes annotated by the GO term GO:0046474. The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O acyl, O alkyl, or O alkenyl group attached to the glycerol residue. (more detail) 30 NA Homo sapiens
WIG001446
Chks in Checkpoint Regulation Chks in Checkpoint Regulation (more detail) 51 NA Homo sapiens
WIG000986
Genes involved in Metabolism of vitamins and cofactors (more detail) 51 NA Homo sapiens
WIG000916
Genes involved in Interleukin 2 signaling (more detail) 41 NA Homo sapiens
WIG000144
Class I PI3K signaling events (more detail) 49 NA Homo sapiens
WIG001443
Ceramide Pathway Ceramide Pathway (more detail) 49 NA Homo sapiens
TAX016046
GO:0005977 biological process glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan compo (more detail) 49 NA Homo sapiens
IEI014583
Protein protein interactors of human gene UBE2L6 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2L6 (SwissProt ID (more detail) 47 17535438 Homo sapiens
TAX017506
GO:0009101 biological process glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that co (more detail) 43 NA Homo sapiens
TAX017581
GO:0009187 biological process cyclic nucleotide metabolic process The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phospha (more detail) 43 NA Homo sapiens
TAX001243
Genes annotated by the GO term GO:0004222. Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. (more detail) 27 NA Homo sapiens
TAX000021
Genes annotated by the GO term GO:0009310. The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. (more detail) 27 NA Homo sapiens
MOX007314
Genes associated with Computational Drug Signature bisindolylmaleimide i Genes associated with Computational Drug Signature bisindolylmaleimide i, curated by the Drug Signat (more detail) 27 25990557 Homo sapiens
TAX001338
Genes annotated by the GO term GO:0004722. Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. (more detail) 24 NA Homo sapiens
MEX001794
Genes associated with Kinase Inhibitor MLN8054 Genes associated with Kinase Inhibitor MLN8054, curated by the Drug Signature Database (DSigDB). (more detail) 24 25990557 Homo sapiens
PEX000547
DEAD: DEAD/DEAH box helicase Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding (more detail) 24 NA Homo sapiens
MEX001309
Genes associated with Kinase Inhibitor CHEMBL552425 Genes associated with Kinase Inhibitor CHEMBL552425, curated by the Drug Signature Database (DSigDB) (more detail) 24 25990557 Homo sapiens
TAX001360
Genes annotated by the GO term GO:0003724. Catalysis of the unwinding of an RNA helix. (more detail) 24 NA Homo sapiens
MEX002139
Genes associated with Kinase Inhibitor JAK Inhibitor I Genes associated with Kinase Inhibitor JAK Inhibitor I, curated by the Drug Signature Database (DSig (more detail) 24 25990557 Homo sapiens
WIG001399
Acetaminophen Pathway, Pharmacokinetics Stylized diagram showing acetaminophen metabolism and transport in the liver and kidney. (more detail) 24 NA Homo sapiens
MEX001535
Genes associated with Kinase Inhibitor go 7874 Genes associated with Kinase Inhibitor go 7874, curated by the Drug Signature Database (DSigDB). (more detail) 24 25990557 Homo sapiens
MEX002337
Genes associated with Kinase Inhibitor su6656 Genes associated with Kinase Inhibitor su6656, curated by the Drug Signature Database (DSigDB). (more detail) 24 25990557 Homo sapiens
TAX001088
Genes annotated by the GO term GO:0042625. Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. (more detail) 24 NA Homo sapiens
WAG000206
O Glycan biosynthesis O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis (more detail) 24 NA Homo sapiens
TAX001150
Genes annotated by the GO term GO:0004519. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. (more detail) 24 NA Homo sapiens
TAX023381
GO:0036442 molecular function proton exporting ATPase activity Enables the transfer of protons from one side of a membrane to the other according to the reaction: (more detail) 24 NA Homo sapiens
TAX015407
GO:0004812 molecular function aminoacyl tRNA ligase activity Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diph (more detail) 24 NA Homo sapiens
TAX019160
GO:0016676 molecular function oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or ele (more detail) 24 NA Homo sapiens
TAX014987
GO:0004114 molecular function 3',5' cyclic nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. (more detail) 24 NA Homo sapiens
TAX029760
GO:0071949 molecular function FAD binding Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleoti (more detail) 24 NA Homo sapiens
TAX017824
GO:0009975 molecular function cyclase activity Catalysis of a ring closure reaction. (more detail) 24 NA Homo sapiens
TAX018434
GO:0015002 molecular function heme copper terminal oxidase activity Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proto (more detail) 24 NA Homo sapiens
TAX025761
GO:0046835 biological process carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the (more detail) 24 NA Homo sapiens
TAX019273
GO:0016875 molecular function ligase activity, forming carbon oxygen bonds Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis (more detail) 24 NA Homo sapiens
TAX019816
GO:0019789 molecular function SUMO transferase activity Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO (more detail) 24 NA Homo sapiens
TAX018802
GO:0015949 biological process nucleobase containing small molecule interconversion The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule i (more detail) 24 NA Homo sapiens
TAX014997
GO:0004129 molecular function cytochrome c oxidase activity Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. (more detail) 24 NA Homo sapiens
TAX017609
GO:0009218 biological process pyrimidine ribonucleotide metabolic process The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of (more detail) 24 NA Homo sapiens
WIG000005
Alpha synuclein signaling (more detail) 32 NA Homo sapiens
MAX000764
Genes required for CTNNB1 [GeneID=1499] activity in DLD 1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen. Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancer (more detail) 32 NA Homo sapiens
TAX016488
GO:0006636 biological process unsaturated fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fat (more detail) 32 NA Homo sapiens
IEI010635
Protein protein interactors of human gene PSMB6 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMB6 (SwissProt ID= (more detail) 58 17535438 Homo sapiens
WIG000650
Genes involved in ABC family proteins mediated transport (more detail) 34 NA Homo sapiens
WIG000644
Vibrio cholerae infection Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-ch (more detail) 54 NA Homo sapiens
WIG001777
VEGF Pathway VEGF Pathway (more detail) 54 NA Homo sapiens
TAX016070
GO:0006007 biological process glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexo (more detail) 29 NA Homo sapiens
TAX016318
GO:0006418 biological process tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of t (more detail) 29 NA Homo sapiens
TAX025586
GO:0046471 biological process phosphatidylglycerol metabolic process The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids (more detail) 29 NA Homo sapiens
WIG000552
Linoleic acid metabolism (more detail) 29 NA Homo sapiens
MEX000260
Genes associated with Approved Drug pentoxifylline Genes associated with Approved Drug pentoxifylline, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
WIG001933
One Carbon Metabolism One Carbon Metabolism (more detail) 29 NA Homo sapiens
WIG000791
Genes involved in Degradation of the extracellular matrix (more detail) 29 NA Homo sapiens
WIG001500
Fc GammaR Pathway Fc-GammaR Pathway (more detail) 38 NA Homo sapiens
MOX015670
Genes associated with Computational Drug Signature Tyrphostin AG 538 Genes associated with Computational Drug Signature Tyrphostin AG 538, curated by the Drug Signature (more detail) 48 25990557 Homo sapiens
MOX005159
Genes associated with Computational Drug Signature Equol Genes associated with Computational Drug Signature Equol, curated by the Drug Signature Database (DS (more detail) 40 25990557 Homo sapiens
WIG001971
Eukaryotic Transcription Initiation Eukaryotic Transcription Initiation (more detail) 42 NA Homo sapiens
WIG002028
Glucuronidation Glucuronidation (more detail) 26 NA Homo sapiens
WAG000393
Glycosylphosphatidylinositol(GPI) anchor biosynthesis Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glyco (more detail) 26 NA Homo sapiens
TAX020950
GO:0031365 biological process N terminal protein amino acid modification The alteration of the N-terminal amino acid residue in a protein. (more detail) 26 NA Homo sapiens
TAX016558
GO:0006730 biological process one carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation (more detail) 26 NA Homo sapiens
TAX020848
GO:0031167 biological process rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. (more detail) 26 NA Homo sapiens
TAX023287
GO:0036151 biological process phosphatidylcholine acyl chain remodeling Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation r (more detail) 26 NA Homo sapiens
TAX019040
GO:0016469 cellular component proton transporting two sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, (more detail) 31 NA Homo sapiens
TAX000541
Genes annotated by the GO term GO:0016540. Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. (more detail) 31 NA Homo sapiens
WIG000961
Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis (more detail) 31 NA Homo sapiens
WIG000735
Genes involved in CD28 co stimulation (more detail) 31 NA Homo sapiens
WAG001219
Galactose metabolism (more detail) 23 NA Homo sapiens
MEX002057
Genes associated with Kinase Inhibitor Kinome 800 Genes associated with Kinase Inhibitor Kinome_800, curated by the Drug Signature Database (DSigDB). (more detail) 23 25990557 Homo sapiens
WIG000568
Nitrogen metabolism (more detail) 23 NA Homo sapiens
MEX002206
Genes associated with Kinase Inhibitor BI 2536 Genes associated with Kinase Inhibitor BI 2536, curated by the Drug Signature Database (DSigDB). (more detail) 23 25990557 Homo sapiens
MAX003001
Genes whose expression most significantly correlated with cancer cell line sensitivity to the proapoptotic ligand APO2 [GeneID=8797] . Apo2L/TRAIL stimulates cancer cell death through the proapoptotic receptors DR4 and DR5, but the det (more detail) 23 NA Homo sapiens
PEX000352
p450: Cytochrome P450 Cytochrome P450s are haem-thiolate proteins 6 involved in the oxidative degradation of various compo (more detail) 23 NA Homo sapiens
TAX001287
Genes annotated by the GO term GO:0016627. Catalysis of an oxidation reduction (redox) reaction in which a CH CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. (more detail) 23 NA Homo sapiens
WAG000199
Sulfur metabolism Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an impo (more detail) 23 NA Homo sapiens
MEX001418
Genes associated with Kinase Inhibitor TSU 68 Genes associated with Kinase Inhibitor TSU-68, curated by the Drug Signature Database (DSigDB). (more detail) 23 25990557 Homo sapiens
FEX002584
Prostate Wang02 25genes Table 1 Candidate genes responsive to (-) epigallocatechin-3-gallate in human prostate cancer LNCaP (more detail) 23 12175522 Homo sapiens
MEX002221
Genes associated with Kinase Inhibitor Sunitinib Genes associated with Kinase Inhibitor Sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 23 25990557 Homo sapiens
WIG001119
Genes involved in Pyrimidine metabolism (more detail) 23 NA Homo sapiens
WIG000877
Genes involved in Glutathione conjugation (more detail) 23 NA Homo sapiens
TAX016106
GO:0006063 biological process uronic acid metabolic process The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived (more detail) 23 NA Homo sapiens
TAX015274
GO:0004622 molecular function lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. (more detail) 23 NA Homo sapiens
TAX028682
GO:0070006 molecular function metalloaminopeptidase activity Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanis (more detail) 23 NA Homo sapiens
TAX019763
GO:0019585 biological process glucuronate metabolic process The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the (more detail) 23 NA Homo sapiens
TAX017483
GO:0009067 biological process aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate famil (more detail) 23 NA Homo sapiens
TAX031999
GO:1901071 biological process glucosamine containing compound metabolic process The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). (more detail) 23 NA Homo sapiens
TAX019258
GO:0016849 molecular function phosphorus oxygen lyase activity Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation (more detail) 23 NA Homo sapiens
TAX019203
GO:0016769 molecular function transferase activity, transferring nitrogenous groups Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). (more detail) 23 NA Homo sapiens
TAX017352
GO:0008574 molecular function ATP dependent microtubule motor activity, plus end directed Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP. (more detail) 23 NA Homo sapiens
TAX023288
GO:0036152 biological process phosphatidylethanolamine acyl chain remodeling Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylat (more detail) 23 NA Homo sapiens
TAX017101
GO:0008171 molecular function O methyltransferase activity Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. (more detail) 23 NA Homo sapiens
TAX031709
GO:0140103 molecular function catalytic activity, acting on a glycoprotein catalytic activity, acting on a glycosylated protein (more detail) 23 NA Homo sapiens
TAX023848
GO:0042451 biological process purine nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a fa (more detail) 23 NA Homo sapiens
TAX025465
GO:0046129 biological process purine ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucle (more detail) 23 NA Homo sapiens
IEI002474
Protein protein interactors of human gene CHFR from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CHFR (SwissProt ID=Q (more detail) 53 17535438 Homo sapiens
WIG001544
HMGB1 Pathway HMGB1 Pathway (more detail) 51 NA Homo sapiens
TAX013301
GO:0000186 biological process activation of MAPKK activity The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). (more detail) 51 NA Homo sapiens
TAX013467
GO:0000726 biological process non recombinational repair A DNA repair process in which that does not require the exchange of genetic material between the bro (more detail) 51 NA Homo sapiens
TAX016244
GO:0006303 biological process double strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or (more detail) 51 NA Homo sapiens
MEX000819
Genes associated with Approved Drug bortezomib Genes associated with Approved Drug bortezomib, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MOX014382
Genes associated with Computational Drug Signature PD 98059 Genes associated with Computational Drug Signature PD 98059, curated by the Drug Signature Database (more detail) 35 25990557 Homo sapiens
WIG001438
Cell Cycle Control of Chromosomal Replication Cell Cycle Control of Chromosomal Replication (more detail) 35 NA Homo sapiens
TAX023894
GO:0042558 biological process pteridine containing compound metabolic process The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyri (more detail) 35 NA Homo sapiens
WIG001647
RAR Alpha/PML Fusion During APL RAR-Alpha/PML Fusion During APL (more detail) 49 NA Homo sapiens
MOX000217
Genes associated with Computational Drug Signature Ursolic acid Genes associated with Computational Drug Signature Ursolic acid, curated by the Drug Signature Datab (more detail) 47 25990557 Homo sapiens
TAX014114
GO:0002200 biological process somatic diversification of immune receptors The somatic process allowing for the production of immune receptors whose specificity is not encoded (more detail) 47 NA Homo sapiens
TAX028710
GO:0070069 cellular component cytochrome complex A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing prot (more detail) 28 NA Homo sapiens
TAX024658
GO:0044275 biological process cellular carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of o (more detail) 28 NA Homo sapiens
TAX019098
GO:0016572 biological process histone phosphorylation The modification of histones by addition of phosphate groups. (more detail) 28 NA Homo sapiens
WIG001191
Genes involved in SHC mediated cascade (more detail) 28 NA Homo sapiens
WAG000080
Dual incision reaction in TC NER (more detail) 28 NA Homo sapiens
WAG000321
Transcription coupled NER (TC NER) (more detail) 28 NA Homo sapiens
WAG000071
Formation of transcription coupled NER (TC NER) repair complex (more detail) 28 NA Homo sapiens
WIG001669
Semaphorin Signaling Semaphorin Signaling (more detail) 39 NA Homo sapiens
WIG000061
Plasma membrane estrogen receptor signaling (more detail) 41 NA Homo sapiens
TAX016537
GO:0006695 biological process cholesterol biosynthetic process The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-o (more detail) 41 NA Homo sapiens
TAX034228
GO:1990391 cellular component DNA repair complex A protein complex involved in DNA repair processes including direct reversal, base excision repair, (more detail) 41 NA Homo sapiens
MOX000194
Genes associated with Computational Drug Signature Myristicin Genes associated with Computational Drug Signature Myristicin, curated by the Drug Signature Databas (more detail) 41 25990557 Homo sapiens
WIG000802
Genes involved in DNA strand elongation (more detail) 30 NA Homo sapiens
TAX000535
Genes annotated by the GO term GO:0046777. The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. (more detail) 30 NA Homo sapiens
TAX001064
Genes annotated by the GO term GO:0016407. Catalysis of the transfer of an acetyl group to an acceptor molecule. (more detail) 25 NA Homo sapiens
WAG000723
RNA Pol II CTD phosphorylation and interaction with CE (more detail) 25 NA Homo sapiens
WIG000535
Glycosylphosphatidylinositol(GPI) anchor biosynthesis Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glyco (more detail) 25 NA Homo sapiens
WIG000896
Genes involved in G beta:gamma signalling through PI3Kgamma (more detail) 25 NA Homo sapiens
WAG000313
RNA Pol II CTD phosphorylation and interaction with CE (more detail) 25 NA Homo sapiens
TAX016354
GO:0006471 biological process protein ADP ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. (more detail) 25 NA Homo sapiens
PEX001208
adh short: short chain dehydrogenase This family contains a wide variety of dehydrogenases. (more detail) 22 NA Homo sapiens
MEX001434
Genes associated with Kinase Inhibitor Brivanib Genes associated with Kinase Inhibitor Brivanib, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001613
Genes associated with Kinase Inhibitor CHEMBL1241473 Genes associated with Kinase Inhibitor CHEMBL1241473, curated by the Drug Signature Database (DSigDB (more detail) 22 25990557 Homo sapiens
TAX019628
GO:0019200 molecular function carbohydrate kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecu (more detail) 22 NA Homo sapiens
MEX001537
Genes associated with Kinase Inhibitor NCGC00346967 01 Genes associated with Kinase Inhibitor NCGC00346967-01, curated by the Drug Signature Database (DSig (more detail) 22 25990557 Homo sapiens
MEX001859
Genes associated with Kinase Inhibitor 405169 16 6 Genes associated with Kinase Inhibitor 405169-16-6, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
WIG000528
Glycosaminoglycan biosynthesis chondroitin sulfate Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide unit (more detail) 22 NA Homo sapiens
TAX001285
Genes annotated by the GO term GO:0016903. Catalysis of an oxidation reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. (more detail) 22 NA Homo sapiens
WIG001958
Fatty Acid Biosynthesis Fatty Acid Biosynthesis (more detail) 22 NA Homo sapiens
TAX032235
GO:1901687 biological process glutathione derivative biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione derivative. (more detail) 22 NA Homo sapiens
FOX000550
Genes in the cancer module 219 (more detail) 22 NA Homo sapiens
WIG000470
Aminoacyl tRNA biosynthesis (more detail) 22 NA Homo sapiens
TAX017611
GO:0009220 biological process pyrimidine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a com (more detail) 22 NA Homo sapiens
TAX028873
GO:0070330 molecular function aromatase activity Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. (more detail) 22 NA Homo sapiens
PEX000769
SET: SET domain SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein i (more detail) 22 NA Homo sapiens
TAX025471
GO:0046135 biological process pyrimidine nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecul (more detail) 22 NA Homo sapiens
TAX001141
Genes annotated by the GO term GO:0008094. Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single or double stranded DNA; drives another reaction. (more detail) 22 NA Homo sapiens
TAX001411
Genes annotated by the GO term GO:0008757. Catalysis of the transfer of a methyl group from S adenosyl L methionine to a substrate. (more detail) 22 NA Homo sapiens
MEX002410
Genes associated with Kinase Inhibitor Gefitinib Genes associated with Kinase Inhibitor Gefitinib, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001972
Genes associated with Kinase Inhibitor 722544 51 6 Genes associated with Kinase Inhibitor 722544-51-6, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
WIG000841
Genes involved in FGFR ligand binding and activation (more detail) 22 NA Homo sapiens
FOX000626
Genes in the cancer module 310 (more detail) 22 NA Homo sapiens
WIG000485
beta Alanine metabolism (more detail) 22 NA Homo sapiens
MEX001895
Genes associated with Kinase Inhibitor Motesanib Genes associated with Kinase Inhibitor Motesanib, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MEX001396
Genes associated with Kinase Inhibitor Gefitinib Genes associated with Kinase Inhibitor Gefitinib, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
TAX025773
GO:0046856 biological process phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol. (more detail) 22 NA Homo sapiens
TAX019225
GO:0016799 molecular function hydrolase activity, hydrolyzing N glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond. (more detail) 22 NA Homo sapiens
WIG000567
Nicotinate and nicotinamide metabolism (more detail) 22 NA Homo sapiens
MEX001956
Genes associated with Kinase Inhibitor 844499 71 4 Genes associated with Kinase Inhibitor 844499-71-4, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
TAX016530
GO:0006688 biological process glycosphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with (more detail) 22 NA Homo sapiens
TAX032234
GO:1901685 biological process glutathione derivative metabolic process The chemical reactions and pathways involving glutathione derivative. (more detail) 22 NA Homo sapiens
FOX000576
Genes in the cancer module 249 (more detail) 22 NA Homo sapiens
FOX000560
Genes in the cancer module 233 (more detail) 22 NA Homo sapiens
MEX001455
Genes associated with Kinase Inhibitor CHEMBL468963 Genes associated with Kinase Inhibitor CHEMBL468963, curated by the Drug Signature Database (DSigDB) (more detail) 22 25990557 Homo sapiens
TAX019290
GO:0016894 molecular function endonuclease activity, active with either ribo or deoxyribonucleic acids and producing 3' phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yi (more detail) 22 NA Homo sapiens
TAX019278
GO:0016881 molecular function acid amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomita (more detail) 22 NA Homo sapiens
TAX020330
GO:0030149 biological process sphingolipid catabolic process The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of l (more detail) 22 NA Homo sapiens
TAX000264
Genes annotated by the GO term GO:0042445. The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. (more detail) 32 NA Homo sapiens
WIG001421
Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics (more detail) 32 NA Homo sapiens
WIG001274
Genes involved in Thrombin signalling through proteinase activated receptors (PARs) (more detail) 32 NA Homo sapiens
TAX019676
GO:0019319 biological process hexose biosynthetic process The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a (more detail) 48 NA Homo sapiens
TAX024420
GO:0043531 molecular function ADP binding Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. (more detail) 34 NA Homo sapiens
WIG001585
NF kappaB Activation by Viruses NF-kappaB Activation by Viruses (more detail) 46 NA Homo sapiens
WIG000504
DNA replication A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DN (more detail) 36 NA Homo sapiens
TAX032596
GO:1902653 biological process secondary alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of secondary alcohol. (more detail) 42 NA Homo sapiens
WIG001587
Alzheimer¿s Disease Pathway Alzheimer¿s Disease Pathway (more detail) 42 NA Homo sapiens
WIG000183
PAR1 mediated thrombin signaling events (more detail) 42 NA Homo sapiens
TAX000308
Genes annotated by the GO term GO:0016042. The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. (more detail) 38 NA Homo sapiens
TAX016119
GO:0006084 biological process acetyl CoA metabolic process The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the su (more detail) 27 NA Homo sapiens
WIG001430
CCR5 Pathway in Macrophages CCR5 Pathway in Macrophages (more detail) 40 NA Homo sapiens
MOX004346
Genes associated with Computational Drug Signature methyldopa Genes associated with Computational Drug Signature methyldopa, curated by the Drug Signature Databas (more detail) 40 25990557 Homo sapiens
WIG000848
Genes involved in Formation of transcription coupled NER (TC NER) repair complex (more detail) 29 NA Homo sapiens
TAX023990
GO:0042743 biological process hydrogen peroxide metabolic process The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byprod (more detail) 29 NA Homo sapiens
MOX013523
Genes associated with Computational Drug Signature LY 294002 Genes associated with Computational Drug Signature LY 294002, curated by the Drug Signature Database (more detail) 29 25990557 Homo sapiens
TAX000463
Genes annotated by the GO term GO:0046489. The chemical reactions and pathways resulting in the formation of phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. (more detail) 24 NA Homo sapiens
WIG000616
Selenoamino acid metabolism (more detail) 24 NA Homo sapiens
TAX000537
Genes annotated by the GO term GO:0006497. The covalent or non covalent attachment of lipid moieties to an amino acid in a protein. (more detail) 24 NA Homo sapiens
TAX000066
Genes annotated by the GO term GO:0016052. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. (more detail) 24 NA Homo sapiens
TAX001276
Genes annotated by the GO term GO:0016410. Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. (more detail) 24 NA Homo sapiens
WIG000969
Genes involved in MAP kinase activation in TLR cascade (more detail) 49 NA Homo sapiens
MOX016467
Genes associated with Computational Drug Signature caffeic acid Genes associated with Computational Drug Signature caffeic acid, curated by the Drug Signature Datab (more detail) 49 25990557 Homo sapiens
IEI008698
Protein protein interactors of human gene NDUFS1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NDUFS1 (SwissProt ID (more detail) 49 17535438 Homo sapiens
WAG000808
RNA polymerase (more detail) 21 NA Homo sapiens
PEX000844
KR: KR domain This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the (more detail) 21 NA Homo sapiens
MEX001818
Genes associated with Kinase Inhibitor TPCA 1 Genes associated with Kinase Inhibitor TPCA-1, curated by the Drug Signature Database (DSigDB). (more detail) 21 25990557 Homo sapiens
WAG000383
Chondroitin sulfate biosynthesis Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide unit (more detail) 21 NA Homo sapiens
WIG001954
Triacylglyceride Synthesis Triacylglyceride Synthesis (more detail) 21 NA Homo sapiens
MEX002120
Genes associated with Kinase Inhibitor GW559768X Genes associated with Kinase Inhibitor GW559768X, curated by the Drug Signature Database (DSigDB). (more detail) 21 25990557 Homo sapiens
PEX002320
adh short C2: Enoyl (Acyl carrier protein) reductase (more detail) 21 NA Homo sapiens
WAG000607
gamma Hexachlorocyclohexane degradation (more detail) 21 NA Homo sapiens
MEX001652
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 21 25990557 Homo sapiens
WIG000673
Genes involved in Acyl chain remodelling of PC (more detail) 21 NA Homo sapiens
MEX002324
Genes associated with Kinase Inhibitor CHEMBL1967116 Genes associated with Kinase Inhibitor CHEMBL1967116, curated by the Drug Signature Database (DSigDB (more detail) 21 25990557 Homo sapiens
WIG000752
Genes involved in Cholesterol biosynthesis (more detail) 21 NA Homo sapiens
FOX000614
Genes in the cancer module 295 (more detail) 21 NA Homo sapiens
FOX000679
Genes in the cancer module 373 (more detail) 21 NA Homo sapiens
WAG001441
1,4 Dichlorobenzene degradation (more detail) 21 NA Homo sapiens
TAX013275
GO:0000146 molecular function microfilament motor activity Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (more detail) 21 NA Homo sapiens
WAG001622
Taurine and hypotaurine metabolism (more detail) 21 NA Homo sapiens
MAX000760
Genes in the blue cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis (more detail) 21 NA Homo sapiens
WAG000605
Biosynthesis of unsaturated fatty acids (more detail) 21 NA Homo sapiens
WIG000531
Glycosaminoglycan degradation (more detail) 21 NA Homo sapiens
WIG001388
Valproic Acid Pathway, Pharmacokinetics Graphic representation of the candidate genes involved in valproic acid pharmacokinetics. (more detail) 21 NA Homo sapiens
TAX022794
GO:0035268 biological process protein mannosylation The addition of a mannose residue to a protein acceptor molecule. (more detail) 21 NA Homo sapiens
TAX017389
GO:0008649 molecular function rRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in (more detail) 21 NA Homo sapiens
TAX015403
GO:0004806 molecular function triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. (more detail) 21 NA Homo sapiens
TAX031708
GO:0140102 molecular function catalytic activity, acting on a rRNA Catalytic activity that acts to modify a ribosomal RNA. (more detail) 21 NA Homo sapiens
TAX014788
GO:0003756 molecular function protein disulfide isomerase activity Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. (more detail) 21 NA Homo sapiens
TAX025468
GO:0046132 biological process pyrimidine ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside i (more detail) 21 NA Homo sapiens
TAX017300
GO:0008483 molecular function transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. (more detail) 21 NA Homo sapiens
TAX015035
GO:0004198 molecular function calcium dependent cysteine type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using (more detail) 21 NA Homo sapiens
TAX019139
GO:0016638 molecular function oxidoreductase activity, acting on the CH NH2 group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or e (more detail) 21 NA Homo sapiens
TAX019268
GO:0016864 molecular function intramolecular oxidoreductase activity, transposing S S bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are th (more detail) 21 NA Homo sapiens
TAX023849
GO:0042454 biological process ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside i (more detail) 21 NA Homo sapiens
TAX025833
GO:0046961 molecular function proton transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: (more detail) 21 NA Homo sapiens
TAX028680
GO:0070003 molecular function threonine type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydr (more detail) 21 NA Homo sapiens
TAX019701
GO:0019373 biological process epoxygenase P450 pathway The chemical reactions and pathways by which arachidonic acid is converted to other compounds includ (more detail) 21 NA Homo sapiens
TAX015038
GO:0004298 molecular function threonine type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which (more detail) 21 NA Homo sapiens
TAX026839
GO:0051156 biological process glucose 6 phosphate metabolic process The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative o (more detail) 21 NA Homo sapiens
TAX015257
GO:0004602 molecular function glutathione peroxidase activity Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. (more detail) 21 NA Homo sapiens
TAX016110
GO:0006067 biological process ethanol metabolic process The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flam (more detail) 21 NA Homo sapiens
TAX018640
GO:0015645 molecular function fatty acid ligase activity Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. (more detail) 21 NA Homo sapiens
WIG001227
Genes involved in Signal amplification (more detail) 31 NA Homo sapiens
IEI014772
Protein protein interactors of human gene USP28 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene USP28 (SwissProt ID= (more detail) 47 17535438 Homo sapiens
IEI004226
Protein protein interactors of human gene EPOR from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EPOR (SwissProt ID=P (more detail) 45 17535438 Homo sapiens
WIG000099
IL8 and CXCR2 mediated signaling events (more detail) 33 NA Homo sapiens
MOX013518
Genes associated with Computational Drug Signature luteolin Genes associated with Computational Drug Signature luteolin, curated by the Drug Signature Database (more detail) 43 25990557 Homo sapiens
TAX023690
GO:0042136 biological process neurotransmitter biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of substances that (more detail) 43 NA Homo sapiens
MOX015829
Genes associated with Computational Drug Signature Velcade(Bortezomib) Genes associated with Computational Drug Signature Velcade(Bortezomib), curated by the Drug Signatur (more detail) 35 25990557 Homo sapiens
TAX030027
GO:0072512 biological process trivalent inorganic cation transport The directed movement of inorganic cations with a valency of three into, out of or within a cell, or (more detail) 41 NA Homo sapiens
TAX018654
GO:0015682 biological process ferric iron transport The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or betwee (more detail) 41 NA Homo sapiens
WIG001090
Genes involved in PLC beta mediated events (more detail) 41 NA Homo sapiens
TAX016384
GO:0006515 biological process protein quality control for misfolded or incompletely synthesized proteins The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. (more detail) 26 NA Homo sapiens
TAX020369
GO:0030201 biological process heparan sulfate proteoglycan metabolic process The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any membe (more detail) 26 NA Homo sapiens
IEI003821
Protein protein interactors of human gene DTX3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DTX3 (SwissProt ID=Q (more detail) 26 17535438 Homo sapiens
WIG000098
IL8 and CXCR1 mediated signaling events (more detail) 26 NA Homo sapiens
WIG000880
Genes involved in Glycolysis (more detail) 28 NA Homo sapiens
WIG001202
Genes involved in Signaling by FGFR1 mutants (more detail) 28 NA Homo sapiens
FOX000543
Genes in the cancer module 210 (more detail) 28 NA Homo sapiens
WIG000409
Proteasome Complex Attachment of the ubiquitin peptide to proteins targets them for proteolytic degradation by a comple (more detail) 28 NA Homo sapiens
TAX019489
GO:0018200 biological process peptidyl glutamic acid modification The modification of peptidyl-glutamic acid. (more detail) 28 NA Homo sapiens
TAX022594
GO:0034661 biological process ncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs (more detail) 28 NA Homo sapiens
TAX016386
GO:0006517 biological process protein deglycosylation The removal of sugar residues from a glycosylated protein. (more detail) 28 NA Homo sapiens
WEX000036
Glycolysis & Glucose Transport The genes related to glycolysis & glucose transport (metabolism) in tumor, immune, stroma using next (more detail) 28 NA Homo sapiens
TAX000077
Genes annotated by the GO term GO:0044275. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. (more detail) 23 NA Homo sapiens
WIG000933
Genes involved in Insulin receptor recycling (more detail) 23 NA Homo sapiens
TAX017187
GO:0008299 biological process isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (more detail) 23 NA Homo sapiens
TAX017656
GO:0009310 biological process amine catabolic process The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakl (more detail) 23 NA Homo sapiens
TAX016153
GO:0006144 biological process purine nucleobase metabolic process The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen (more detail) 23 NA Homo sapiens
TAX023884
GO:0042537 biological process benzene containing compound metabolic process The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, co (more detail) 23 NA Homo sapiens
TAX023815
GO:0042402 biological process cellular biogenic amine catabolic process The chemical reactions and pathways occurring at the level of individual cells resulting in the brea (more detail) 23 NA Homo sapiens
MOX001490
Genes associated with Computational Drug Signature catechol Genes associated with Computational Drug Signature catechol, curated by the Drug Signature Database (more detail) 46 25990557 Homo sapiens
TAX032217
GO:1901661 biological process quinone metabolic process The chemical reactions and pathways involving quinone. (more detail) 30 NA Homo sapiens
WIG001615
Parkinson's Disease Pathway Parkinson's Disease Pathway (more detail) 44 NA Homo sapiens
WIG000573
Nucleotide excision repair Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by c (more detail) 44 NA Homo sapiens
WIG000917
Genes involved in Interleukin 3, 5 and GM CSF signaling (more detail) 44 NA Homo sapiens
WIG000057
ErbB2/ErbB3 signaling events (more detail) 44 NA Homo sapiens
FOX000702
Genes in the cancer module 403 (more detail) 44 NA Homo sapiens
IEI014256
Protein protein interactors of human gene TRIM5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM5 (SwissProt ID= (more detail) 44 17535438 Homo sapiens
TAX014808
GO:0003841 molecular function 1 acylglycerol 3 phosphate O acyltransferase activity Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol- (more detail) 20 NA Homo sapiens
TAX025579
GO:0046463 biological process acylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or tr (more detail) 20 NA Homo sapiens
TAX017225
GO:0008373 molecular function sialyltransferase activity Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of (more detail) 20 NA Homo sapiens
TAX030894
GO:0097503 biological process sialylation The covalent attachment of sialic acid to a substrate molecule. (more detail) 20 NA Homo sapiens
TAX025692
GO:0046653 biological process tetrahydrofolate metabolic process The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a fola (more detail) 20 NA Homo sapiens
TAX020980
GO:0031418 molecular function L ascorbic acid binding Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4- (more detail) 20 NA Homo sapiens
TAX025576
GO:0046460 biological process neutral lipid biosynthetic process The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only solubl (more detail) 20 NA Homo sapiens
TAX014912
GO:0004012 molecular function phospholipid translocating ATPase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by (more detail) 20 NA Homo sapiens
TAX029571
GO:0071617 molecular function lysophospholipid acyltransferase activity Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. (more detail) 20 NA Homo sapiens
TAX019002
GO:0016408 molecular function C acyltransferase activity Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. (more detail) 20 NA Homo sapiens
TAX016422
GO:0006555 biological process methionine metabolic process The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a su (more detail) 20 NA Homo sapiens
TAX025454
GO:0046112 biological process nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base t (more detail) 20 NA Homo sapiens
TAX025549
GO:0046386 biological process deoxyribose phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phospho (more detail) 20 NA Homo sapiens
TAX023709
GO:0042171 molecular function lysophosphatidic acid acyltransferase activity Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphati (more detail) 20 NA Homo sapiens
MEX001585
Genes associated with Kinase Inhibitor NCGC00346963 01 Genes associated with Kinase Inhibitor NCGC00346963-01, curated by the Drug Signature Database (DSig (more detail) 20 25990557 Homo sapiens
WIG000674
Genes involved in Acyl chain remodelling of PE (more detail) 20 NA Homo sapiens
TAX001197
Genes annotated by the GO term GO:0016811. Catalysis of the hydrolysis of any non peptide carbon nitrogen bond in a linear amide. (more detail) 20 NA Homo sapiens
FEX001381
Leukemia Bradbury05 23genes RelatedProteinsMC TABLE S2 Expression of deacetylases and related proteins in mononuclear cells from 23 primary AML pa (more detail) 20 16121216 Homo sapiens
WAG000400
Lysine biosynthesis (more detail) 20 NA Homo sapiens
TAX001430
Genes annotated by the GO term GO:0016763. Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). (more detail) 20 NA Homo sapiens
MEX001882
Genes associated with Kinase Inhibitor 918505 84 7 Genes associated with Kinase Inhibitor 918505-84-7, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
WAG000615
Heparan sulfate biosynthesis Heparan sulfate (HS) and heparin (Hep) are glycosaminoglycans with repeating disaccharide units that (more detail) 20 NA Homo sapiens
FOX000642
Genes in the cancer module 327 (more detail) 20 NA Homo sapiens
WAG001224
Alkaloid biosynthesis II (more detail) 20 NA Homo sapiens
WIG000486
Biosynthesis of unsaturated fatty acids (more detail) 20 NA Homo sapiens
MEX001484
Genes associated with Kinase Inhibitor Kinome 511 Genes associated with Kinase Inhibitor Kinome_511, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
WAG001438
Nicotinate and nicotinamide metabolism (more detail) 20 NA Homo sapiens
FOX000835
Genes in the cancer module 78 (more detail) 20 NA Homo sapiens
MEX002422
Genes associated with Kinase Inhibitor Lenvatinib Genes associated with Kinase Inhibitor Lenvatinib, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
MEX001726
Genes associated with Kinase Inhibitor GSK1007102B Genes associated with Kinase Inhibitor GSK1007102B, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
WIG001328
Phenytoin Pathway, Pharmacokinetics Genes involved in the metabolism of phenytoin in the human liver cell. (more detail) 20 NA Homo sapiens
MEX001208
Genes associated with Kinase Inhibitor gw5074 Genes associated with Kinase Inhibitor gw5074, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
MEX001606
Genes associated with Kinase Inhibitor Lck Inhibitor Genes associated with Kinase Inhibitor Lck Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 20 25990557 Homo sapiens
TAX001089
Genes annotated by the GO term GO:0015662. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high energy aspartyl phosphoryl enzyme intermediate. (more detail) 20 NA Homo sapiens
FEX001380
Leukemia Bradbury05 23genes AssociatedProteinsPMBC Table S1 Expression of deacetylases and associated proteins in peripheral blood mononuclear cells (P (more detail) 20 16121216 Homo sapiens
WAG001222
Glyoxylate and dicarboxylate metabolism (more detail) 20 NA Homo sapiens
MOX003172
Genes associated with Computational Drug Signature PURPURIN Genes associated with Computational Drug Signature PURPURIN, curated by the Drug Signature Database (more detail) 42 25990557 Homo sapiens
MEX000565
Genes associated with Approved Drug methyldopa Genes associated with Approved Drug methyldopa, curated by the Drug Signature Database (DSigDB). (more detail) 42 25990557 Homo sapiens
MOX001631
Genes associated with Computational Drug Signature Allyl sulfide Genes associated with Computational Drug Signature Allyl sulfide, curated by the Drug Signature Data (more detail) 42 25990557 Homo sapiens
MOX000196
Genes associated with Computational Drug Signature naringenin Genes associated with Computational Drug Signature naringenin, curated by the Drug Signature Databas (more detail) 42 25990557 Homo sapiens
TAX020343
GO:0030166 biological process proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in (more detail) 32 NA Homo sapiens
WIG000064
FAS (CD95) signaling pathway (more detail) 38 NA Homo sapiens
IEI010638
Protein protein interactors of human gene PSMB9 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMB9 (SwissProt ID= (more detail) 38 17535438 Homo sapiens
MOX017106
Genes associated with Computational Drug Signature methyldopa Genes associated with Computational Drug Signature methyldopa, curated by the Drug Signature Databas (more detail) 36 25990557 Homo sapiens
WIG000953
Genes involved in Iron uptake and transport (more detail) 36 NA Homo sapiens
TAX024002
GO:0042759 biological process long chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty (more detail) 25 NA Homo sapiens
TAX001270
Genes annotated by the GO term GO:0019205. Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. (more detail) 25 NA Homo sapiens
WIG000682
Genes involved in ADP signalling through P2Y purinoceptor 1 (more detail) 25 NA Homo sapiens
IEI007654
Protein protein interactors of human gene MAP3K11 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MAP3K11 (SwissProt I (more detail) 45 17535438 Homo sapiens
TAX016125
GO:0006094 biological process gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol (more detail) 45 NA Homo sapiens
WAG001156
mRNA Capping (more detail) 27 NA Homo sapiens
TAX000043
Genes annotated by the GO term GO:0006725. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons. (more detail) 27 NA Homo sapiens
WIG000307
Phospholipids as signalling intermediaries Sphingosine-1-phosphate (S1P) is an example of lipid messengers with both intracellular and extracel (more detail) 27 NA Homo sapiens
WIG001152
Genes involved in Regulation of Water Balance by Renal Aquaporins (more detail) 43 NA Homo sapiens
TAX001122
Genes annotated by the GO term GO:0048037. Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. (more detail) 22 NA Homo sapiens
WIG001366
Doxorubicin Pathway, Pharmacokinetics Diagrammatic representation of the transport and metabolism of doxorubicin. (more detail) 22 NA Homo sapiens
TAX001292
Genes annotated by the GO term GO:0019825. Interacting selectively with oxygen (O2). (more detail) 22 NA Homo sapiens
TAX016408
GO:0006541 biological process glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. (more detail) 22 NA Homo sapiens
TAX017545
GO:0009147 biological process pyrimidine nucleoside triphosphate metabolic process The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consist (more detail) 22 NA Homo sapiens
MOX005959
Genes associated with Computational Drug Signature 4,5,6,7 tetrabromobenzotriazole Genes associated with Computational Drug Signature 4,5,6,7-tetrabromobenzotriazole, curated by the D (more detail) 29 25990557 Homo sapiens
WAG001001
Nucleotide excision repair Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky D damage caused by com (more detail) 41 NA Homo sapiens
WIG001516
G2 M Phase Transition G2-M Phase Transition (more detail) 41 NA Homo sapiens
WIG000232
JNK MAPK Pathway na (more detail) 39 NA Homo sapiens
TAX000441
Genes annotated by the GO term GO:0009117. The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono , di or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). (more detail) 39 NA Homo sapiens
TAX013281
GO:0000154 biological process rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecu (more detail) 39 NA Homo sapiens
TAX024726
GO:0044390 molecular function ubiquitin like protein conjugating enzyme binding Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as (more detail) 39 NA Homo sapiens
TAX023514
GO:0038128 biological process ERBB2 signaling pathway A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of rec (more detail) 31 NA Homo sapiens
FOX000622
Genes in the cancer module 305 (more detail) 19 NA Homo sapiens
MEX002011
Genes associated with Kinase Inhibitor SB 203580 Genes associated with Kinase Inhibitor SB 203580, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
WIG002023
Tamoxifen metabolism Tamoxifen metabolism (more detail) 19 NA Homo sapiens
MEX002268
Genes associated with Kinase Inhibitor indirubin deriv. 7a Genes associated with Kinase Inhibitor indirubin deriv. 7a, curated by the Drug Signature Database ( (more detail) 19 25990557 Homo sapiens
MOX015246
Genes associated with Computational Drug Signature Sunitinib Genes associated with Computational Drug Signature Sunitinib, curated by the Drug Signature Database (more detail) 19 25990557 Homo sapiens
WAG001434
Valine, leucine and isoleucine biosynthesis (more detail) 19 NA Homo sapiens
MEX001463
Genes associated with Kinase Inhibitor LDN193189 Genes associated with Kinase Inhibitor LDN193189, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
TAX001440
Genes annotated by the GO term GO:0019198. The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal dependent manner. (more detail) 19 NA Homo sapiens
MEX001386
Genes associated with Kinase Inhibitor Masitinib Genes associated with Kinase Inhibitor Masitinib, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
MEX001650
Genes associated with Kinase Inhibitor GNE 7915 Genes associated with Kinase Inhibitor GNE-7915, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
WAG000394
Tetrachloroethene degradation (more detail) 19 NA Homo sapiens
TAX001213
Genes annotated by the GO term GO:0016860. Catalysis of an oxidation reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. (more detail) 19 NA Homo sapiens
MEX002301
Genes associated with Kinase Inhibitor TCMDC 138201 Genes associated with Kinase Inhibitor TCMDC-138201, curated by the Drug Signature Database (DSigDB) (more detail) 19 25990557 Homo sapiens
MOX015811
Genes associated with Computational Drug Signature Valspodar Genes associated with Computational Drug Signature Valspodar, curated by the Drug Signature Database (more detail) 19 25990557 Homo sapiens
MEX001890
Genes associated with Kinase Inhibitor Kinome 1221 Genes associated with Kinase Inhibitor Kinome_1221, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
WIG001244
Genes involved in Synthesis of bile acids and bile salts (more detail) 19 NA Homo sapiens
WIG001992
Urea cycle and metabolism of amino groups Urea cycle and metabolism of amino groups (more detail) 19 NA Homo sapiens
WAG001230
Vitamin B6 metabolism (more detail) 19 NA Homo sapiens
MEX001303
Genes associated with Kinase Inhibitor Kinome 1198 Genes associated with Kinase Inhibitor Kinome_1198, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
TAX015206
GO:0004529 molecular function exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molec (more detail) 19 NA Homo sapiens
TAX031519
GO:0102567 molecular function phospholipase A2 activity (consuming 1,2 dipalmitoylphosphatidylcholine) Catalysis of the reaction: 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn- (more detail) 19 NA Homo sapiens
TAX015295
GO:0004653 molecular function polypeptide N acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosami (more detail) 19 NA Homo sapiens
TAX017641
GO:0009264 biological process deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound (more detail) 19 NA Homo sapiens
TAX022408
GO:0034311 biological process diol metabolic process The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, g (more detail) 19 NA Homo sapiens
TAX015544
GO:0005003 molecular function ephrin receptor activity Combining with an ephrin to initiate a change in cell activity. (more detail) 19 NA Homo sapiens
TAX018959
GO:0016289 molecular function CoA hydrolase activity Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. (more detail) 19 NA Homo sapiens
TAX019291
GO:0016895 molecular function exodeoxyribonuclease activity, producing 5' phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide r (more detail) 19 NA Homo sapiens
TAX019777
GO:0019682 biological process glyceraldehyde 3 phosphate metabolic process The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate (more detail) 19 NA Homo sapiens
TAX031520
GO:0102568 molecular function phospholipase A2 activity consuming 1,2 dioleoylphosphatidylethanolamine) Catalysis of the reaction: 1-18:1-2-18:1-phosphatidylethanolamine + H2O = 1-oleoyl-sn-glycero-3-phos (more detail) 19 NA Homo sapiens
TAX014915
GO:0004016 molecular function adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. (more detail) 19 NA Homo sapiens
TAX022827
GO:0035338 biological process long chain fatty acyl CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any de (more detail) 19 NA Homo sapiens
TAX019211
GO:0016780 molecular function phosphotransferase activity, for other substituted phosphate groups Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl re (more detail) 19 NA Homo sapiens
TAX016185
GO:0006206 biological process pyrimidine nucleobase metabolic process The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogeno (more detail) 19 NA Homo sapiens
TAX022177
GO:0033619 biological process membrane protein proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or e (more detail) 37 NA Homo sapiens
TAX000193
Genes annotated by the GO term GO:0015980. (more detail) 37 NA Homo sapiens
MOX014776
Genes associated with Computational Drug Signature Redoxal Genes associated with Computational Drug Signature Redoxal, curated by the Drug Signature Database ( (more detail) 37 25990557 Homo sapiens
WAG000620
DNA replication A complex network of interacting proteins and enzymes is required for D replication. Generally, D re (more detail) 33 NA Homo sapiens
WIG001699
TNF Induced Apoptosis Implicating Sphingolipids TNF-Induced Apoptosis Implicating Sphingolipids (more detail) 33 NA Homo sapiens
TAX023310
GO:0036260 biological process RNA capping The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA (more detail) 33 NA Homo sapiens
TAX017706
GO:0009452 biological process 7 methylguanosine RNA capping The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine lin (more detail) 33 NA Homo sapiens
WIG001993
Glycogen Metabolism Glycogen Metabolism (more detail) 35 NA Homo sapiens
TAX019030
GO:0016445 biological process somatic diversification of immunoglobulins The somatic process that results in the generation of sequence diversity of immunoglobulins. (more detail) 35 NA Homo sapiens
WIG001335
Fluoropyrimidine Pathway, Pharmacokinetics Representation of the metabolic pathways for fluoropyrimidines. (more detail) 24 NA Homo sapiens
WIG001308
Genes involved in tRNA Aminoacylation (more detail) 24 NA Homo sapiens
FOX000840
Genes in the cancer module 82 (more detail) 24 NA Homo sapiens
WIG000958
Genes involved in Kinesins (more detail) 24 NA Homo sapiens
WIG001554
IL 1 Pathway IL-1 Pathway (more detail) 42 NA Homo sapiens
WIG001077
Genes involved in PI3K events in ERBB2 signaling (more detail) 42 NA Homo sapiens
IEI004764
Protein protein interactors of human gene FH from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene FH (SwissProt ID=P07 (more detail) 42 17535438 Homo sapiens
TAX031590
GO:0106118 biological process regulation of sterol biosynthetic process Any process that modulates the frequency, rate or extent of a sterol biosynthetic process. (more detail) 42 NA Homo sapiens
TAX025129
GO:0045540 biological process regulation of cholesterol biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resu (more detail) 42 NA Homo sapiens
TAX019484
GO:0018195 biological process peptidyl arginine modification The modification of peptidyl-arginine. (more detail) 26 NA Homo sapiens
TAX033406
GO:1904353 biological process regulation of telomere capping Any process that modulates the frequency, rate or extent of telomere capping. (more detail) 26 NA Homo sapiens
TAX000312
Genes annotated by the GO term GO:0042158. The chemical reactions and pathways resulting in the formation of any conjugated, water soluble protein in which the nonprotein moiety consists of a lipid or lipids. (more detail) 26 NA Homo sapiens
WIG001236
Genes involved in Sphingolipid de novo biosynthesis (more detail) 26 NA Homo sapiens
WIG001094
Genes involved in Post translational modification: synthesis of GPI anchored proteins (more detail) 26 NA Homo sapiens
WIG000050
EPHB forward signaling (more detail) 40 NA Homo sapiens
WEX000031
FGFR Signaling The genes related to fgfr signaling (signaling pathways) in tumor using next-generation sequencer (N (more detail) 40 NA Homo sapiens
MOX005343
Genes associated with Computational Drug Signature 1,9 Pyrazoloanthrone Genes associated with Computational Drug Signature 1,9-Pyrazoloanthrone, curated by the Drug Signatu (more detail) 28 25990557 Homo sapiens
TAX000765
Genes annotated by the GO term GO:0006665. The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long chain amine diol sphingosine or a closely related base (a sphingoid). (more detail) 28 NA Homo sapiens
TAX019525
GO:0018345 biological process protein palmitoylation The covalent attachment of a palmitoyl group to a protein. (more detail) 28 NA Homo sapiens
TAX032554
GO:1902555 cellular component endoribonuclease complex A protein complex which is capable of endoribonuclease activity. (more detail) 28 NA Homo sapiens
TAX028983
GO:0070536 biological process protein K63 linked deubiquitination A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquiti (more detail) 28 NA Homo sapiens
TAX033891
GO:1905348 cellular component endonuclease complex A protein complex which is capable of endonuclease activity. (more detail) 28 NA Homo sapiens
MOX007098
Genes associated with Computational Drug Signature Asterric acid Genes associated with Computational Drug Signature Asterric acid, curated by the Drug Signature Data (more detail) 38 25990557 Homo sapiens
TAX017493
GO:0009081 biological process branched chain amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, com (more detail) 21 NA Homo sapiens
TAX025119
GO:0045503 molecular function dynein light chain binding Interacting selectively and non-covalently with a light chain of the dynein complex. (more detail) 21 NA Homo sapiens
TAX001138
Genes annotated by the GO term GO:0004536. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. (more detail) 21 NA Homo sapiens
TAX013469
GO:0000729 biological process DNA double strand break processing The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand (more detail) 21 NA Homo sapiens
FOX000697
Genes in the cancer module 4 (more detail) 21 NA Homo sapiens
MOX007549
Genes associated with Computational Drug Signature Cdk9 Inhibitor II Genes associated with Computational Drug Signature Cdk9 Inhibitor II, curated by the Drug Signature (more detail) 21 25990557 Homo sapiens
MOX012690
Genes associated with Computational Drug Signature Fisetin Genes associated with Computational Drug Signature Fisetin, curated by the Drug Signature Database ( (more detail) 21 25990557 Homo sapiens
TAX001275
Genes annotated by the GO term GO:0008080. Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. (more detail) 21 NA Homo sapiens
TAX022148
GO:0033572 biological process transferrin transport The directed movement of transferrin into, out of or within a cell, or between cells, by means of so (more detail) 36 NA Homo sapiens
MOX014817
Genes associated with Computational Drug Signature Rhein Genes associated with Computational Drug Signature Rhein, curated by the Drug Signature Database (DS (more detail) 36 25990557 Homo sapiens
WIG001803
ABCG and ABCA Regulation of Sterol Metabolism ABCG and ABCA Regulation of Sterol Metabolism (more detail) 30 NA Homo sapiens
FEX001891
Lung Kobayashi06 42genes Table 2. E2F target genes down-regulated by CL-387 785 at 24 hours (more detail) 30 17145885 Homo sapiens
TAX016241
GO:0006298 biological process mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds w (more detail) 30 NA Homo sapiens
TAX016229
GO:0006284 biological process base excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excisio (more detail) 30 NA Homo sapiens
WIG001694
Thrombopoietin Pathway Thrombopoietin Pathway (more detail) 32 NA Homo sapiens
TAX016286
GO:0006370 biological process 7 methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. (more detail) 32 NA Homo sapiens
TAX028590
GO:0061783 molecular function peptidoglycan muralytic activity A catalytic activity that contributes to the degradation of peptidoglycan. (more detail) 18 NA Homo sapiens
FOX000613
Genes in the cancer module 294 (more detail) 18 NA Homo sapiens
MEX002303
Genes associated with Kinase Inhibitor Kinome 1901 Genes associated with Kinase Inhibitor Kinome_1901, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
FOX000431
Genes in the cancer module 102 (more detail) 18 NA Homo sapiens
TAX001159
Genes annotated by the GO term GO:0004527. Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. (more detail) 18 NA Homo sapiens
MEX001286
Genes associated with Kinase Inhibitor Syk Inhibitor Genes associated with Kinase Inhibitor Syk Inhibitor, curated by the Drug Signature Database (DSigDB (more detail) 18 25990557 Homo sapiens
MEX001452
Genes associated with Kinase Inhibitor AGN PC 09LLI8 Genes associated with Kinase Inhibitor AGN-PC-09LLI8, curated by the Drug Signature Database (DSigDB (more detail) 18 25990557 Homo sapiens
WIG001331
Tamoxifen Pathway, Pharmacokinetics Tamoxifen metabolism in the liver. (more detail) 18 NA Homo sapiens
MEX002201
Genes associated with Kinase Inhibitor 405554 55 4 Genes associated with Kinase Inhibitor 405554-55-4, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX002371
Genes associated with Kinase Inhibitor Kinome 454 Genes associated with Kinase Inhibitor Kinome_454, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX001999
Genes associated with Kinase Inhibitor Quizartinib Genes associated with Kinase Inhibitor Quizartinib, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
TAX025528
GO:0046337 biological process phosphatidylethanolamine metabolic process The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glyceropho (more detail) 18 NA Homo sapiens
TAX001104
Genes annotated by the GO term GO:0016830. Catalysis of the cleavage of C C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. (more detail) 18 NA Homo sapiens
MEX002032
Genes associated with Kinase Inhibitor Syk Inhibitor II Genes associated with Kinase Inhibitor Syk Inhibitor II, curated by the Drug Signature Database (DSi (more detail) 18 25990557 Homo sapiens
TAX017351
GO:0008569 molecular function ATP dependent microtubule motor activity, minus end directed Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP. (more detail) 18 NA Homo sapiens
TAX019723
GO:0019432 biological process triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of gl (more detail) 18 NA Homo sapiens
FOX000663
Genes in the cancer module 354 (more detail) 18 NA Homo sapiens
TAX015361
GO:0004745 molecular function retinol dehydrogenase activity Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. (more detail) 18 NA Homo sapiens
TAX017250
GO:0008409 molecular function 5' 3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues f (more detail) 18 NA Homo sapiens
MEX002295
Genes associated with Kinase Inhibitor NVP TAE684 Genes associated with Kinase Inhibitor NVP-TAE684, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
TAX001359
Genes annotated by the GO term GO:0008186. Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction. (more detail) 18 NA Homo sapiens
TAX001144
Genes annotated by the GO term GO:0034061. Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer. (more detail) 18 NA Homo sapiens
TAX015107
GO:0004383 molecular function guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. (more detail) 18 NA Homo sapiens
TAX015215
GO:0004550 molecular function nucleoside diphosphate kinase activity Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. (more detail) 18 NA Homo sapiens
MEX000105
Genes associated with Approved Drug valproic acid Genes associated with Approved Drug valproic acid, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX002234
Genes associated with Kinase Inhibitor czc 25146 Genes associated with Kinase Inhibitor czc-25146, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
WAG001227
Phenylalanine metabolism (more detail) 18 NA Homo sapiens
TAX022680
GO:0034979 molecular function NAD dependent protein deacetylase activity Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. (more detail) 18 NA Homo sapiens
TAX017045
GO:0008074 cellular component guanylate cyclase complex, soluble Complex that possesses guanylate cyclase activity and is not bound to a membrane. (more detail) 18 NA Homo sapiens
MEX002326
Genes associated with Kinase Inhibitor Kinome 858 Genes associated with Kinase Inhibitor Kinome_858, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
TAX001206
Genes annotated by the GO term GO:0004428. Catalysis of the phosphorylation of myo inositol (1,2,3,5/4,6 cyclohexanehexol) or a phosphatidylinositol. (more detail) 18 NA Homo sapiens
WAG000385
Styrene degradation (more detail) 18 NA Homo sapiens
TAX027429
GO:0052695 biological process cellular glucuronidation The modification of an organic chemical by the conjugation of glucuronic acid. The substances result (more detail) 18 NA Homo sapiens
MEX001105
Genes associated with Approved Drug regorafenib Genes associated with Approved Drug regorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MEX002297
Genes associated with Kinase Inhibitor ( ) Epigallocatechin gallate Genes associated with Kinase Inhibitor (-)-Epigallocatechin gallate, curated by the Drug Signature D (more detail) 18 25990557 Homo sapiens
WIG000992
Genes involved in Mitochondrial tRNA aminoacylation (more detail) 18 NA Homo sapiens
WIG001042
Genes involved in N glycan antennae elongation in the medial/trans Golgi (more detail) 18 NA Homo sapiens
TAX027445
GO:0052745 molecular function inositol phosphate phosphatase activity Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This r (more detail) 18 NA Homo sapiens
TAX014304
GO:0002566 biological process somatic diversification of immune receptors via somatic mutation The process in which immune receptor genes are diversified through somatic mutation. (more detail) 18 NA Homo sapiens
PEX002478
JmjC: JmjC domain, hydroxylase The JmjC domain belongs to the Cupin superfamily 3. JmjC-domain proteins may be protein hydroxylases (more detail) 18 NA Homo sapiens
TAX017495
GO:0009083 biological process branched chain amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched (more detail) 18 NA Homo sapiens
MEX001921
Genes associated with Kinase Inhibitor LRRK2 IN 1 Genes associated with Kinase Inhibitor LRRK2-IN-1, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
WIG001242
Genes involved in Sulfur amino acid metabolism (more detail) 23 NA Homo sapiens
WIG001275
Genes involved in Thromboxane signalling through TP receptor (more detail) 23 NA Homo sapiens
WIG001468
DNA Methylation and Transcriptional Repression DNA Methylation and Transcriptional Repression (more detail) 23 NA Homo sapiens
TAX020843
GO:0031146 biological process SCF dependent proteasomal ubiquitin dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis (more detail) 23 NA Homo sapiens
TAX017130
GO:0008210 biological process estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the (more detail) 23 NA Homo sapiens
TAX000951
Genes annotated by the GO term GO:0005792. Any of the small, heterogeneous, artifactual, vesicular particles, 50 150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g. (more detail) 41 NA Homo sapiens
WIG001292
Genes involved in Transferrin endocytosis and recycling (more detail) 25 NA Homo sapiens
WIG001391
Vemurafenib Pathway, Pharmacodynamics Vemurafenib Pathway, Pharmacodynamics (more detail) 25 NA Homo sapiens
TAX017476
GO:0009060 biological process aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and f (more detail) 39 NA Homo sapiens
TAX022207
GO:0033683 biological process nucleotide excision repair, DNA incision A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision oc (more detail) 39 NA Homo sapiens
MOX001700
Genes associated with Computational Drug Signature 1,2 NAPHTHOQUINONE Genes associated with Computational Drug Signature 1,2-NAPHTHOQUINONE, curated by the Drug Signature (more detail) 39 25990557 Homo sapiens
MEX000402
Genes associated with Approved Drug colchicine Genes associated with Approved Drug colchicine, curated by the Drug Signature Database (DSigDB). (more detail) 39 25990557 Homo sapiens
MOX017791
Genes associated with Computational Drug Signature suramin Genes associated with Computational Drug Signature suramin, curated by the Drug Signature Database ( (more detail) 39 25990557 Homo sapiens
WIG000071
GMCSF mediated signaling events (more detail) 37 NA Homo sapiens
WEX000034
Glutamine Metabolism The genes related to glutamine metabolism (metabolism) in tumor, immune, stroma using next-generatio (more detail) 27 NA Homo sapiens
TAX025424
GO:0046068 biological process cGMP metabolic process The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. (more detail) 27 NA Homo sapiens
MOX003517
Genes associated with Computational Drug Signature Carfilzomib Genes associated with Computational Drug Signature Carfilzomib, curated by the Drug Signature Databa (more detail) 27 25990557 Homo sapiens
WIG000898
Genes involved in G protein activation (more detail) 27 NA Homo sapiens
TAX000258
Genes annotated by the GO term GO:0046483. The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). (more detail) 27 NA Homo sapiens
MEX000398
Genes associated with Approved Drug levodopa Genes associated with Approved Drug levodopa, curated by the Drug Signature Database (DSigDB). (more detail) 35 25990557 Homo sapiens
MOX016143
Genes associated with Computational Drug Signature beta D Glucose 6 phosphate Genes associated with Computational Drug Signature beta-D-Glucose 6-phosphate, curated by the Drug S (more detail) 35 25990557 Homo sapiens
TAX016588
GO:0006778 biological process porphyrin containing compound metabolic process The chemical reactions and pathways involving any member of a large group of derivatives or analogs (more detail) 35 NA Homo sapiens
TAX016578
GO:0006760 biological process folic acid containing compound metabolic process The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group (more detail) 29 NA Homo sapiens
MOX000482
Genes associated with Computational Drug Signature Alizarin Genes associated with Computational Drug Signature Alizarin, curated by the Drug Signature Database (more detail) 29 25990557 Homo sapiens
WIG000998
Genes involved in mRNA Capping (more detail) 29 NA Homo sapiens
WIG000870
Genes involved in Glucagon signaling in metabolic regulation (more detail) 33 NA Homo sapiens
WIG000872
Genes involved in Gluconeogenesis (more detail) 33 NA Homo sapiens
MOX000389
Genes associated with Computational Drug Signature Myricitrin Genes associated with Computational Drug Signature Myricitrin, curated by the Drug Signature Databas (more detail) 33 25990557 Homo sapiens
MOX002638
Genes associated with Computational Drug Signature alpha Hexylcinnamaldehyde Genes associated with Computational Drug Signature alpha-Hexylcinnamaldehyde, curated by the Drug Si (more detail) 33 25990557 Homo sapiens
MOX016417
Genes associated with Computational Drug Signature TERT BUTYL HYDROPEROXIDE Genes associated with Computational Drug Signature TERT-BUTYL HYDROPEROXIDE, curated by the Drug Sig (more detail) 33 25990557 Homo sapiens
TAX016370
GO:0006491 biological process N glycan processing The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosacc (more detail) 20 NA Homo sapiens
TAX017484
GO:0009068 biological process aspartate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate famil (more detail) 20 NA Homo sapiens
TAX020193
GO:0022616 biological process DNA strand elongation The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end o (more detail) 20 NA Homo sapiens
IEI014615
Protein protein interactors of human gene UBOX5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBOX5 (SwissProt ID= (more detail) 20 17535438 Homo sapiens
TAX000572
Genes annotated by the GO term GO:0006029. The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. (more detail) 20 NA Homo sapiens
WIG001734
Mechanism of Anthrax Toxins Mechanism of Anthrax Toxins (more detail) 20 NA Homo sapiens
WIG000759
Genes involved in Citric acid cycle (TCA cycle) (more detail) 20 NA Homo sapiens
WIG000897
Genes involved in G beta:gamma signalling through PLC beta (more detail) 20 NA Homo sapiens
WIG000887
Genes involved in GPVI mediated activation cascade (more detail) 31 NA Homo sapiens
WIG000014
Nongenotropic Androgen signaling (more detail) 31 NA Homo sapiens
TAX022751
GO:0035173 molecular function histone kinase activity Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-so (more detail) 17 NA Homo sapiens
TAX015858
GO:0005666 cellular component RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a (more detail) 17 NA Homo sapiens
TAX025954
GO:0047617 molecular function acyl CoA hydrolase activity Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. (more detail) 17 NA Homo sapiens
TAX019260
GO:0016854 molecular function racemase and epimerase activity Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. (more detail) 17 NA Homo sapiens
TAX019197
GO:0016755 molecular function transferase activity, transferring amino acyl groups Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). (more detail) 17 NA Homo sapiens
TAX019031
GO:0016446 biological process somatic hypermutation of immunoglobulin genes Mutations occurring somatically that result in amino acid changes in the rearranged V regions of imm (more detail) 17 NA Homo sapiens
TAX024026
GO:0042800 molecular function histone methyltransferase activity (H3 K4 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L (more detail) 17 NA Homo sapiens
TAX017239
GO:0008392 molecular function arachidonic acid epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyei (more detail) 17 NA Homo sapiens
TAX014870
GO:0003951 molecular function NAD+ kinase activity Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). (more detail) 17 NA Homo sapiens
TAX018821
GO:0016018 molecular function cyclosporin A binding Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains (more detail) 17 NA Homo sapiens
TAX024200
GO:0043174 biological process nucleoside salvage Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucl (more detail) 17 NA Homo sapiens
TAX024493
GO:0043649 biological process dicarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic ac (more detail) 17 NA Homo sapiens
TAX016392
GO:0006525 biological process arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. (more detail) 17 NA Homo sapiens
TAX018968
GO:0016307 molecular function phosphatidylinositol phosphate kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bis (more detail) 17 NA Homo sapiens
TAX024495
GO:0043651 biological process linoleic acid metabolic process The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that (more detail) 17 NA Homo sapiens
TAX017238
GO:0008391 molecular function arachidonic acid monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduc (more detail) 17 NA Homo sapiens
TAX017218
GO:0008353 molecular function RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA (more detail) 17 NA Homo sapiens
TAX025407
GO:0046037 biological process GMP metabolic process The chemical reactions and pathways involving GMP, guanosine monophosphate. (more detail) 17 NA Homo sapiens
TAX027262
GO:0051923 biological process sulfation The addition of a sulfate group to a molecule. (more detail) 17 NA Homo sapiens
TAX019144
GO:0016646 molecular function oxidoreductase activity, acting on the CH NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or el (more detail) 17 NA Homo sapiens
TAX019178
GO:0016722 molecular function oxidoreductase activity, oxidizing metal ions Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. (more detail) 17 NA Homo sapiens
PEX002548
Helicase C: Helicase conserved C terminal domain The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide (more detail) 17 NA Homo sapiens
MEX000745
Genes associated with Approved Drug vardenafil Genes associated with Approved Drug vardenafil, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
TAX013250
GO:0000097 biological process sulfur amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, com (more detail) 17 NA Homo sapiens
WIG000590
Phenylalanine metabolism (more detail) 17 NA Homo sapiens
FOX000659
Genes in the cancer module 349 (more detail) 17 NA Homo sapiens
PEX000666
Kinesin: Kinesin motor domain (more detail) 17 NA Homo sapiens
WAG001618
Reductive carboxylate cycle (CO2 fixation) (more detail) 17 NA Homo sapiens
WIG001416
Cyclophosphamide Pathway, Pharmacodynamics Model non-tissue-specific cancer cell displaying genes which may be involved in the cyclophosphamide (more detail) 17 NA Homo sapiens
MEX002171
Genes associated with Kinase Inhibitor PF 03814735 Genes associated with Kinase Inhibitor PF-03814735, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MEX001852
Genes associated with Kinase Inhibitor PD166285 Genes associated with Kinase Inhibitor PD166285, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
TAX001093
Genes annotated by the GO term GO:0004004. Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix. (more detail) 17 NA Homo sapiens
MEX001683
Genes associated with Kinase Inhibitor Kinome 452 Genes associated with Kinase Inhibitor Kinome_452, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MEX001699
Genes associated with Kinase Inhibitor GW806742X Genes associated with Kinase Inhibitor GW806742X, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MEX001654
Genes associated with Kinase Inhibitor CHEMBL2062936 Genes associated with Kinase Inhibitor CHEMBL2062936, curated by the Drug Signature Database (DSigDB (more detail) 17 25990557 Homo sapiens
WIG002024
Sulfation Biotransformation Reaction Sulfation Biotransformation Reaction (more detail) 17 NA Homo sapiens
MEX002318
Genes associated with Kinase Inhibitor GW801372X Genes associated with Kinase Inhibitor GW801372X, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
FOX000764
Genes in the cancer module 492 (more detail) 17 NA Homo sapiens
WAG001629
D Glutamine and D glutamate metabolism (more detail) 17 NA Homo sapiens
WIG001344
Bisphosphonate Pathway, Pharmacodynamics Representation of genes involved in bisphosphonates' effects in osteoclasts. (more detail) 17 NA Homo sapiens
MEX001560
Genes associated with Kinase Inhibitor TWS119 Genes associated with Kinase Inhibitor TWS119, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
WIG000576
One carbon pool by folate (more detail) 17 NA Homo sapiens
WIG000731
Genes involved in Branched chain amino acid catabolism (more detail) 17 NA Homo sapiens
MEX001909
Genes associated with Kinase Inhibitor gw8510 Genes associated with Kinase Inhibitor gw8510, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MEX001914
Genes associated with Kinase Inhibitor 929095 18 1 Genes associated with Kinase Inhibitor 929095-18-1, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
WAG000814
Methionine metabolism (more detail) 22 NA Homo sapiens
MAX001953
Genes involved in free fatty acid oxidation; based on literature and sequence annotation resources and coverted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 22 NA Homo sapiens
WIG000888
Genes involved in GRB2 events in ERBB2 signaling (more detail) 22 NA Homo sapiens
FEX000744
Breast Speers09 24genes Supplementary Table 3. Kinases overexpressed in ER-positive breast cancer (more detail) 22 19808870 Homo sapiens
MOX000542
Genes associated with Computational Drug Signature Amentoflavone Genes associated with Computational Drug Signature Amentoflavone, curated by the Drug Signature Data (more detail) 22 25990557 Homo sapiens
WIG000058
ErbB4 signaling events (more detail) 38 NA Homo sapiens
IEI011157
Protein protein interactors of human gene RECQL5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RECQL5 (SwissProt ID (more detail) 38 17535438 Homo sapiens
GEX000249
bladder cancer bladder cancer associated genes. PAGER constructed this gene set by grouping all genes which are ass (more detail) 36 NA Homo sapiens
MOX000923
Genes associated with Computational Drug Signature cinnamyl alcohol Genes associated with Computational Drug Signature cinnamyl alcohol, curated by the Drug Signature D (more detail) 36 25990557 Homo sapiens
MOX014519
Genes associated with Computational Drug Signature piceatannol Genes associated with Computational Drug Signature piceatannol, curated by the Drug Signature Databa (more detail) 34 25990557 Homo sapiens
MOX004709
Genes associated with Computational Drug Signature suramin Genes associated with Computational Drug Signature suramin, curated by the Drug Signature Database ( (more detail) 34 25990557 Homo sapiens
TAX023783
GO:0042339 biological process keratan sulfate metabolic process The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units (more detail) 34 NA Homo sapiens
TAX016377
GO:0006505 biological process GPI anchor metabolic process The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechan (more detail) 26 NA Homo sapiens
TAX000152
Genes annotated by the GO term GO:0030705. The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell. (more detail) 26 NA Homo sapiens
WIG001381
Metformin Pathway, Pharmacodynamic Metformin Pathway, Pharmacodynamic (more detail) 32 NA Homo sapiens
WAG000625
phospholipids as signalling intermediaries Sphingosine-1-phosphate (S1P) is an example of lipid messengers with both intracellular and extracel (more detail) 28 NA Homo sapiens
MOX017198
Genes associated with Computational Drug Signature Carfilzomib Genes associated with Computational Drug Signature Carfilzomib, curated by the Drug Signature Databa (more detail) 30 25990557 Homo sapiens
TAX000538
Genes annotated by the GO term GO:0006487. The posttranslational glycosylation of protein via the N4 atom of peptidyl asparagine or the N1' atom peptidyl tryptophan. (more detail) 30 NA Homo sapiens
WIG001028
Genes involved in NOD1/2 Signaling Pathway (more detail) 30 NA Homo sapiens
IEI011807
Protein protein interactors of human gene SATB1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SATB1 (SwissProt ID= (more detail) 30 17535438 Homo sapiens
WIG000720
Genes involved in Base Excision Repair (more detail) 19 NA Homo sapiens
TAX019698
GO:0019370 biological process leukotriene biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically a (more detail) 19 NA Homo sapiens
TAX023239
GO:0036065 biological process fucosylation The covalent attachment of a fucosyl group to an acceptor molecule. (more detail) 19 NA Homo sapiens
TAX017617
GO:0009226 biological process nucleotide sugar biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide- (more detail) 19 NA Homo sapiens
TAX017546
GO:0009148 biological process pyrimidine nucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate (more detail) 19 NA Homo sapiens
TAX025485
GO:0046174 biological process polyol catabolic process The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing t (more detail) 19 NA Homo sapiens
TAX019536
GO:0018410 biological process C terminal protein amino acid modification The alteration of the C-terminal amino acid residue in a protein. (more detail) 19 NA Homo sapiens
TAX018854
GO:0016075 biological process rRNA catabolic process The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural (more detail) 19 NA Homo sapiens
MEX002341
Genes associated with Kinase Inhibitor GW806290X Genes associated with Kinase Inhibitor GW806290X, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
TAX001249
Genes annotated by the GO term GO:0003777. Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). (more detail) 16 NA Homo sapiens
MOX011958
Genes associated with Computational Drug Signature Cianidanol Genes associated with Computational Drug Signature Cianidanol, curated by the Drug Signature Databas (more detail) 16 25990557 Homo sapiens
TAX001286
Genes annotated by the GO term GO:0016620. Catalysis of an oxidation reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. (more detail) 16 NA Homo sapiens
MEX001349
Genes associated with Kinase Inhibitor CHEMBL1982466 Genes associated with Kinase Inhibitor CHEMBL1982466, curated by the Drug Signature Database (DSigDB (more detail) 16 25990557 Homo sapiens
WIG000578
Other glycan degradation (more detail) 16 NA Homo sapiens
WIG000583
Pantothenate and CoA biosynthesis (more detail) 16 NA Homo sapiens
MEX001440
Genes associated with Kinase Inhibitor Kinome 866 Genes associated with Kinase Inhibitor Kinome_866, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
FEX000581
Breast Finetti08 16genes Table 1. List of the 16 kinases from the gene cluster identified byquality threshold-clustering (more detail) 16 18245477 Homo sapiens
TAX001121
Genes annotated by the GO term GO:0050662. Interacting selectively with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. (more detail) 16 NA Homo sapiens
PEX001876
ADH zinc N: Zinc binding dehydrogenase (more detail) 16 NA Homo sapiens
MEX001867
Genes associated with Kinase Inhibitor HG 9 91 01 Genes associated with Kinase Inhibitor HG-9-91-01, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
MEX001310
Genes associated with Kinase Inhibitor Kinome 473 Genes associated with Kinase Inhibitor Kinome_473, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
WIG000536
Glyoxylate and dicarboxylate metabolism (more detail) 16 NA Homo sapiens
TAX001414
Genes annotated by the GO term GO:0016790. Catalysis of the reaction: RCO SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO SR'), such as that found in acetyl coenzyme A. (more detail) 16 NA Homo sapiens
WAG000399
Cysteine metabolism (more detail) 16 NA Homo sapiens
WAG000402
One carbon pool by folate (more detail) 16 NA Homo sapiens
WIG000656
Genes involved in Activated point mutants of FGFR2 (more detail) 16 NA Homo sapiens
WIG000675
Genes involved in Acyl chain remodelling of PG (more detail) 16 NA Homo sapiens
MAX000762
Genes in the green cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis (more detail) 16 NA Homo sapiens
WIG000622
Steroid biosynthesis (more detail) 16 NA Homo sapiens
WAG001613
Caffeine metabolism (more detail) 16 NA Homo sapiens
MEX001336
Genes associated with Kinase Inhibitor Kinome 2010 Genes associated with Kinase Inhibitor Kinome_2010, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
MEX001468
Genes associated with Kinase Inhibitor Kinome 1242 Genes associated with Kinase Inhibitor Kinome_1242, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
MEX001830
Genes associated with Kinase Inhibitor CHEMBL463931 Genes associated with Kinase Inhibitor CHEMBL463931, curated by the Drug Signature Database (DSigDB) (more detail) 16 25990557 Homo sapiens
MAX000763
Genes in the red cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis (more detail) 16 NA Homo sapiens
WIG000594
Primary bile acid biosynthesis Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile ac (more detail) 16 NA Homo sapiens
TAX001196
Genes annotated by the GO term GO:0016814. Catalysis of the hydrolysis of any non peptide carbon nitrogen bond in a cyclic amidine, a compound of the form R C(=NH) NH2. (more detail) 16 NA Homo sapiens
WIG002027
Estrogen metabolism Estrogen metabolism (more detail) 16 NA Homo sapiens
FOX000773
Genes in the cancer module 505 (more detail) 16 NA Homo sapiens
WAG000392
Glycosaminoglycan degradation (more detail) 16 NA Homo sapiens
FEX001680
Leukemia Messina10 16genes Table 4. PK Genes Specifically Expressed in B-NEG Patients Versus at Least 2 Other Groups (more detail) 16 20564080 Homo sapiens
TAX001361
Genes annotated by the GO term GO:0034062. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. (more detail) 16 NA Homo sapiens
TAX019229
GO:0016805 molecular function dipeptidase activity Catalysis of the hydrolysis of a dipeptide. (more detail) 16 NA Homo sapiens
TAX019155
GO:0016668 molecular function oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hy (more detail) 16 NA Homo sapiens
TAX015543
GO:0005001 molecular function transmembrane receptor protein tyrosine phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 16 NA Homo sapiens
TAX019623
GO:0019184 biological process nonribosomal peptide biosynthetic process The biosynthetic process in which peptide bond formation occurs in the absence of the translational (more detail) 16 NA Homo sapiens
TAX014972
GO:0004089 molecular function carbonate dehydratase activity Catalysis of the reaction: H2CO3 = CO2 + H2O. (more detail) 16 NA Homo sapiens
TAX028910
GO:0070403 molecular function NAD+ binding Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinu (more detail) 16 NA Homo sapiens
TAX023177
GO:0035970 biological process peptidyl threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. (more detail) 16 NA Homo sapiens
TAX019401
GO:0017136 molecular function NAD dependent histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This react (more detail) 16 NA Homo sapiens
TAX023895
GO:0042559 biological process pteridine containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of any compound containing pteridine (more detail) 16 NA Homo sapiens
TAX026206
GO:0048531 molecular function beta 1,3 galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, formin (more detail) 16 NA Homo sapiens
TAX028683
GO:0070008 molecular function serine type exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus (more detail) 16 NA Homo sapiens
TAX019141
GO:0016641 molecular function oxidoreductase activity, acting on the CH NH2 group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or e (more detail) 16 NA Homo sapiens
TAX019626
GO:0019198 molecular function transmembrane receptor protein phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 16 NA Homo sapiens
TAX014902
GO:0003995 molecular function acyl CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. (more detail) 16 NA Homo sapiens
TAX017301
GO:0008484 molecular function sulfuric ester hydrolase activity Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfur (more detail) 16 NA Homo sapiens
TAX017936
GO:0010485 molecular function H4 histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. (more detail) 16 NA Homo sapiens
TAX015313
GO:0004675 molecular function transmembrane receptor protein serine/threonine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to in (more detail) 16 NA Homo sapiens
TAX026500
GO:0050664 molecular function oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or el (more detail) 16 NA Homo sapiens
TAX025589
GO:0046475 biological process glycerophospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivati (more detail) 16 NA Homo sapiens
TAX024154
GO:0043101 biological process purine containing compound salvage Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or n (more detail) 16 NA Homo sapiens
TAX014881
GO:0003964 molecular function RNA directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes (more detail) 16 NA Homo sapiens
TAX015301
GO:0004659 molecular function prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). (more detail) 16 NA Homo sapiens
TAX017061
GO:0008106 molecular function alcohol dehydrogenase (NADP+) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. (more detail) 16 NA Homo sapiens
TAX025622
GO:0046527 molecular function glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrat (more detail) 16 NA Homo sapiens
TAX016068
GO:0006004 biological process fucose metabolic process The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers (more detail) 16 NA Homo sapiens
TAX015326
GO:0004697 molecular function protein kinase C activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylgl (more detail) 16 NA Homo sapiens
TAX017600
GO:0009208 biological process pyrimidine ribonucleoside triphosphate metabolic process The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound con (more detail) 16 NA Homo sapiens
TAX030707
GO:0097153 molecular function cysteine type endopeptidase activity involved in apoptotic process Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 16 NA Homo sapiens
MOX000907
Genes associated with Computational Drug Signature POTASSIUM BROMATE Genes associated with Computational Drug Signature POTASSIUM BROMATE, curated by the Drug Signature (more detail) 21 25990557 Homo sapiens
WIG001068
Genes involved in Peroxisomal lipid metabolism (more detail) 21 NA Homo sapiens
MOX007316
Genes associated with Computational Drug Signature bisindolylmaleimide IX Genes associated with Computational Drug Signature bisindolylmaleimide IX, curated by the Drug Signa (more detail) 21 25990557 Homo sapiens
WIG000683
Genes involved in ADP signalling through P2Y purinoceptor 12 (more detail) 21 NA Homo sapiens
TAX000138
Genes annotated by the GO term GO:0051188. The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. (more detail) 21 NA Homo sapiens
MEX001103
Genes associated with Approved Drug cefotaxime sodium salt Genes associated with Approved Drug cefotaxime sodium salt, curated by the Drug Signature Database ( (more detail) 21 25990557 Homo sapiens
TAX017680
GO:0009404 biological process toxin metabolic process The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) th (more detail) 21 NA Homo sapiens
TAX019710
GO:0019400 biological process alditol metabolic process The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyc (more detail) 21 NA Homo sapiens
TAX013556
GO:0000959 biological process mitochondrial RNA metabolic process The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occu (more detail) 35 NA Homo sapiens
WIG000056
EGF receptor (ErbB1) signaling pathway (more detail) 35 NA Homo sapiens
MOX000388
Genes associated with Computational Drug Signature morin Genes associated with Computational Drug Signature morin, curated by the Drug Signature Database (DS (more detail) 35 25990557 Homo sapiens
MOX000315
Genes associated with Computational Drug Signature CUMENE HYDROPEROXIDE Genes associated with Computational Drug Signature CUMENE HYDROPEROXIDE, curated by the Drug Signatu (more detail) 23 25990557 Homo sapiens
MOX006180
Genes associated with Computational Drug Signature 5 Amino 2 naphthalenesulfonic acid Genes associated with Computational Drug Signature 5-Amino-2-naphthalenesulfonic acid, curated by th (more detail) 23 25990557 Homo sapiens
TAX017120
GO:0008198 molecular function ferrous iron binding Interacting selectively and non-covalently with ferrous iron, Fe(II). (more detail) 23 NA Homo sapiens
TAX025064
GO:0045332 biological process phospholipid translocation The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leafl (more detail) 23 NA Homo sapiens
WIG000869
Genes involved in Global Genomic NER (GG NER) (more detail) 33 NA Homo sapiens
IEI010628
Protein protein interactors of human gene PSMA8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PSMA8 (SwissProt ID= (more detail) 33 17535438 Homo sapiens
WIG001781
4 1BB Pathway 4-1BB Pathway (more detail) 31 NA Homo sapiens
MOX004106
Genes associated with Computational Drug Signature floxuridine Genes associated with Computational Drug Signature floxuridine, curated by the Drug Signature Databa (more detail) 31 25990557 Homo sapiens
MOX000707
Genes associated with Computational Drug Signature Plumbagin Genes associated with Computational Drug Signature Plumbagin, curated by the Drug Signature Database (more detail) 31 25990557 Homo sapiens
WIG001113
Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation (more detail) 25 NA Homo sapiens
WIG000927
Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline (more detail) 25 NA Homo sapiens
MOX001530
Genes associated with Computational Drug Signature 1,4 NAPHTHOQUINONE Genes associated with Computational Drug Signature 1,4-NAPHTHOQUINONE, curated by the Drug Signature (more detail) 25 25990557 Homo sapiens
TAX019469
GO:0018126 biological process protein hydroxylation The addition of a hydroxy group to a protein amino acid. (more detail) 25 NA Homo sapiens
MOX006330
Genes associated with Computational Drug Signature 7 AMINO 4 HYDROXY 2 NAPHTHALENESULFONIC ACID Genes associated with Computational Drug Signature 7-AMINO-4-HYDROXY-2-NAPHTHALENESULFONIC ACID, cur (more detail) 29 25990557 Homo sapiens
WIG000166
S1P3 pathway (more detail) 29 NA Homo sapiens
WIG000846
Genes involved in Formation of the HIV 1 Early Elongation Complex (more detail) 29 NA Homo sapiens
WIG001975
MAPK Cascade MAPK Cascade (more detail) 29 NA Homo sapiens
IEI005311
Protein protein interactors of human gene GNB3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GNB3 (SwissProt ID=P (more detail) 29 17535438 Homo sapiens
IEI007698
Protein protein interactors of human gene MAPK8IP3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MAPK8IP3 (SwissProt (more detail) 29 17535438 Homo sapiens
IEI008705
Protein protein interactors of human gene NDUFS8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NDUFS8 (SwissProt ID (more detail) 29 17535438 Homo sapiens
MOX000814
Genes associated with Computational Drug Signature Benzo(a)pyrene 7,8 dihydrodiol Genes associated with Computational Drug Signature Benzo(a)pyrene 7,8-dihydrodiol, curated by the Dr (more detail) 27 25990557 Homo sapiens
WIG000830
Genes involved in Extension of Telomeres (more detail) 27 NA Homo sapiens
MOX005086
Genes associated with Computational Drug Signature benzoic acid Genes associated with Computational Drug Signature benzoic acid, curated by the Drug Signature Datab (more detail) 27 25990557 Homo sapiens
MOX007515
Genes associated with Computational Drug Signature catechol Genes associated with Computational Drug Signature catechol, curated by the Drug Signature Database (more detail) 27 25990557 Homo sapiens
TAX001192
Genes annotated by the GO term GO:0015078. Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. (more detail) 27 NA Homo sapiens
MOX004764
Genes associated with Computational Drug Signature ticlopidine Genes associated with Computational Drug Signature ticlopidine, curated by the Drug Signature Databa (more detail) 18 25990557 Homo sapiens
MOX015857
Genes associated with Computational Drug Signature vinblastine Genes associated with Computational Drug Signature vinblastine, curated by the Drug Signature Databa (more detail) 18 25990557 Homo sapiens
WIG001243
Genes involved in Synthesis and interconversion of nucleotide di and triphosphates (more detail) 18 NA Homo sapiens
TAX000774
Genes annotated by the GO term GO:0044272. The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. (more detail) 18 NA Homo sapiens
TAX000474
Genes annotated by the GO term GO:0005976. The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages. (more detail) 18 NA Homo sapiens
FOX000705
Genes in the cancer module 408 (more detail) 18 NA Homo sapiens
WIG000837
Genes involved in Fatty Acyl CoA Biosynthesis (more detail) 18 NA Homo sapiens
MOX013298
Genes associated with Computational Drug Signature KN 62 Genes associated with Computational Drug Signature KN-62, curated by the Drug Signature Database (DS (more detail) 18 25990557 Homo sapiens
MOX002268
Genes associated with Computational Drug Signature N Hydroxy phip Genes associated with Computational Drug Signature N-Hydroxy phip, curated by the Drug Signature Dat (more detail) 18 25990557 Homo sapiens
WIG000875
Genes involved in Glucuronidation (more detail) 18 NA Homo sapiens
TAX000030
Genes annotated by the GO term GO:0006040. The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. (more detail) 18 NA Homo sapiens
TAX023991
GO:0042744 biological process hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). (more detail) 18 NA Homo sapiens
TAX016132
GO:0006103 biological process 2 oxoglutarate metabolic process The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is (more detail) 18 NA Homo sapiens
TAX023284
GO:0036148 biological process phosphatidylglycerol acyl chain remodeling Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation (more detail) 18 NA Homo sapiens
TAX018886
GO:0016137 biological process glycoside metabolic process The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is sub (more detail) 18 NA Homo sapiens
TAX017610
GO:0009219 biological process pyrimidine deoxyribonucleotide metabolic process The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of (more detail) 18 NA Homo sapiens
WIG001318
Genes involved in Xenobiotics (more detail) 15 NA Homo sapiens
TAX000571
Genes annotated by the GO term GO:0030166. The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. (more detail) 15 NA Homo sapiens
WAG000997
Limonene and pinene degradation (more detail) 15 NA Homo sapiens
WIG000266
Roles of fl arrestin dependent Recruitment of Src Kinases in GPCR Signaling The binding of -arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyr (more detail) 15 NA Homo sapiens
WIG001330
Estrogen Metabolism Pathway Estrogen metabolism in the liver. (more detail) 15 NA Homo sapiens
MEX001518
Genes associated with Kinase Inhibitor GDC 0941 Genes associated with Kinase Inhibitor GDC-0941, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
WIG000628
Terpenoid backbone biosynthesis (more detail) 15 NA Homo sapiens
TAX001409
Genes annotated by the GO term GO:0008484. Catalysis of the reaction: RSO R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. (more detail) 15 NA Homo sapiens
MAX000761
Genes in the gray cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis (more detail) 15 NA Homo sapiens
WIG001420
Methotrexate Pathway (Cancer Cell), Pharmacodynamics Methotrexate cellular disposition and effects. (more detail) 15 NA Homo sapiens
MEX002345
Genes associated with Kinase Inhibitor bisindolylmaleimide i Genes associated with Kinase Inhibitor bisindolylmaleimide i, curated by the Drug Signature Database (more detail) 15 25990557 Homo sapiens
MEX001495
Genes associated with Kinase Inhibitor H 89 DIHYDROCHLORIDE Genes associated with Kinase Inhibitor H-89 DIHYDROCHLORIDE, curated by the Drug Signature Database (more detail) 15 25990557 Homo sapiens
WIG002006
Biogenic Amine Synthesis Biogenic Amine Synthesis (more detail) 15 NA Homo sapiens
FOX000724
Genes in the cancer module 431 (more detail) 15 NA Homo sapiens
MOX014298
Genes associated with Computational Drug Signature oxindole i Genes associated with Computational Drug Signature oxindole i, curated by the Drug Signature Databas (more detail) 15 25990557 Homo sapiens
MEX001973
Genes associated with Kinase Inhibitor GSK429286A Genes associated with Kinase Inhibitor GSK429286A, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX002132
Genes associated with Kinase Inhibitor CGP 60474 Genes associated with Kinase Inhibitor CGP 60474, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
FOX000780
Genes in the cancer module 519 (more detail) 15 NA Homo sapiens
MAX002681
Selected electrophile and drug detoxication genes down regulated in A549 and H460 cells (lung cancer) upon knockdown of NFE2L2 [GeneID=4780] by RNAi. Nuclear factor erythroid-2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that re (more detail) 15 NA Homo sapiens
MEX002180
Genes associated with Kinase Inhibitor Alsterpaullone, 2 Cyanoethyl Genes associated with Kinase Inhibitor Alsterpaullone, 2-Cyanoethyl, curated by the Drug Signature D (more detail) 15 25990557 Homo sapiens
MEX001548
Genes associated with Kinase Inhibitor su6656 Genes associated with Kinase Inhibitor su6656, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX001966
Genes associated with Kinase Inhibitor CHEMBL1950303 Genes associated with Kinase Inhibitor CHEMBL1950303, curated by the Drug Signature Database (DSigDB (more detail) 15 25990557 Homo sapiens
WIG001246
Genes involved in Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol (more detail) 15 NA Homo sapiens
PEX001185
Proteasome: Proteasome subunit The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essenti (more detail) 15 NA Homo sapiens
TAX001101
Genes annotated by the GO term GO:0019200. Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. (more detail) 15 NA Homo sapiens
TAX013599
GO:0001056 molecular function RNA polymerase III activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA (more detail) 15 NA Homo sapiens
MEX002164
Genes associated with Kinase Inhibitor GSK1220512A Genes associated with Kinase Inhibitor GSK1220512A, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
FOX000524
Genes in the cancer module 194 (more detail) 15 NA Homo sapiens
FOX000557
Genes in the cancer module 227 (more detail) 15 NA Homo sapiens
FOX000746
Genes in the cancer module 462 (more detail) 15 NA Homo sapiens
WAG000522
Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol (more detail) 15 NA Homo sapiens
TAX001063
Genes annotated by the GO term GO:0008375. Catalysis of the transfer of an N acetylglucosaminyl residue from UDP N acetyl glucosamine to an oligosaccharide. (more detail) 15 NA Homo sapiens
MEX001133
Genes associated with Approved Drug eribulin mesylate Genes associated with Approved Drug eribulin mesylate, curated by the Drug Signature Database (DSigD (more detail) 15 25990557 Homo sapiens
FEX001389
Leukemia Chiaretti05 16genes Table 4. Kinase genes with high-level gene expression in samples without known molecular rearrangeme (more detail) 15 16243790 Homo sapiens
TAX001169
Genes annotated by the GO term GO:0004364. Catalysis of the reaction: R X + glutathione = H X + R S glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. (more detail) 15 NA Homo sapiens
WIG001924
Fatty Acid Omega Oxidation Fatty Acid Omega Oxidation (more detail) 15 NA Homo sapiens
MEX001046
Genes associated with Approved Drug ixabepilone Genes associated with Approved Drug ixabepilone, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX002159
Genes associated with Kinase Inhibitor Kinome 6 Genes associated with Kinase Inhibitor Kinome_6, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX001864
Genes associated with Kinase Inhibitor Torin 2 Genes associated with Kinase Inhibitor Torin 2, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
WIG001503
Feeder Pathways for Glycolysis Feeder Pathways for Glycolysis (more detail) 15 NA Homo sapiens
WAG000396
Alkaloid biosynthesis I (more detail) 15 NA Homo sapiens
MEX001388
Genes associated with Kinase Inhibitor Kinome 406 Genes associated with Kinase Inhibitor Kinome_406, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX001079
Genes associated with Approved Drug vargatef Genes associated with Approved Drug vargatef, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MEX001086
Genes associated with Approved Drug cabazitaxel Genes associated with Approved Drug cabazitaxel, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
TAX022522
GO:0034483 molecular function heparan sulfate sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5' (more detail) 15 NA Homo sapiens
TAX017150
GO:0008242 molecular function omega peptidase activity Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by is (more detail) 15 NA Homo sapiens
TAX022407
GO:0034310 biological process primary alcohol catabolic process The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcoho (more detail) 15 NA Homo sapiens
TAX021445
GO:0032300 cellular component mismatch repair complex Any complex formed of proteins that act in mismatch repair. (more detail) 15 NA Homo sapiens
TAX024577
GO:0044036 biological process cell wall macromolecule metabolic process The chemical reactions and pathways involving macromolecules forming, or destined to form, part of t (more detail) 15 NA Homo sapiens
TAX018938
GO:0016254 biological process preassembly of GPI anchor in ER membrane The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the e (more detail) 15 NA Homo sapiens
TAX018797
GO:0015936 biological process coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')panta (more detail) 15 NA Homo sapiens
TAX023285
GO:0036149 biological process phosphatidylinositol acyl chain remodeling Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation (more detail) 15 NA Homo sapiens
TAX015214
GO:0004549 molecular function tRNA specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. (more detail) 15 NA Homo sapiens
TAX019678
GO:0019321 biological process pentose metabolic process The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five car (more detail) 15 NA Homo sapiens
TAX016452
GO:0006586 biological process indolalkylamine metabolic process The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives contain (more detail) 15 NA Homo sapiens
TAX015201
GO:0004523 molecular function RNA DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. (more detail) 15 NA Homo sapiens
TAX016064
GO:0006000 biological process fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose (more detail) 15 NA Homo sapiens
TAX022131
GO:0033539 biological process fatty acid beta oxidation using acyl CoA dehydrogenase A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which convert (more detail) 15 NA Homo sapiens
TAX016356
GO:0006474 biological process N terminal protein amino acid acetylation The acetylation of the N-terminal amino acid of proteins. (more detail) 15 NA Homo sapiens
TAX016496
GO:0006646 biological process phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a (more detail) 15 NA Homo sapiens
TAX027444
GO:0052744 molecular function phosphatidylinositol monophosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phospha (more detail) 15 NA Homo sapiens
TAX025949
GO:0047555 molecular function 3',5' cyclic GMP phosphodiesterase activity Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. (more detail) 15 NA Homo sapiens
TAX016090
GO:0006044 biological process N acetylglucosamine metabolic process The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structur (more detail) 15 NA Homo sapiens
TAX015131
GO:0004438 molecular function phosphatidylinositol 3 phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo- (more detail) 15 NA Homo sapiens
TAX015216
GO:0004551 molecular function nucleotide diphosphatase activity Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. (more detail) 15 NA Homo sapiens
TAX031557
GO:0106018 molecular function phosphatidylinositol 3,5 bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-my (more detail) 15 NA Homo sapiens
TAX018786
GO:0015923 molecular function mannosidase activity Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cycl (more detail) 15 NA Homo sapiens
TAX019256
GO:0016846 molecular function carbon sulfur lyase activity Catalysis of the elimination of hydrogen sulfide or substituted H2S. (more detail) 15 NA Homo sapiens
TAX015334
GO:0004708 molecular function MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu (more detail) 15 NA Homo sapiens
TAX014988
GO:0004115 molecular function 3',5' cyclic AMP phosphodiesterase activity Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. (more detail) 15 NA Homo sapiens
TAX017601
GO:0009209 biological process pyrimidine ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosp (more detail) 15 NA Homo sapiens
TAX014925
GO:0004029 molecular function aldehyde dehydrogenase (NAD) activity Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. (more detail) 15 NA Homo sapiens
TAX018789
GO:0015926 molecular function glucosidase activity Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cycl (more detail) 15 NA Homo sapiens
TAX022409
GO:0034312 biological process diol biosynthetic process The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two (more detail) 15 NA Homo sapiens
TAX016572
GO:0006750 biological process glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutam (more detail) 15 NA Homo sapiens
TAX025046
GO:0045277 cellular component respiratory chain complex IV A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, inc (more detail) 15 NA Homo sapiens
TAX022019
GO:0033178 cellular component proton transporting two sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes A (more detail) 15 NA Homo sapiens
TAX022132
GO:0033540 biological process fatty acid beta oxidation using acyl CoA oxidase A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans (more detail) 15 NA Homo sapiens
TAX017527
GO:0009129 biological process pyrimidine nucleoside monophosphate metabolic process The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consis (more detail) 15 NA Homo sapiens
TAX017630
GO:0009250 biological process glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consistin (more detail) 20 NA Homo sapiens
TAX016047
GO:0005978 biological process glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly b (more detail) 20 NA Homo sapiens
MAX001956
Genes involved in glycolysis; based on literature and sequence annotation resources and converted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 20 NA Homo sapiens
WIG001743
Mismatch Repair Pathway in Eukaryotes Mismatch Repair Pathway in Eukaryotes (more detail) 20 NA Homo sapiens
WIG000049
EPHA forward signaling (more detail) 34 NA Homo sapiens
MOX017372
Genes associated with Computational Drug Signature N Stearoyl D sphingosine Genes associated with Computational Drug Signature N-Stearoyl-D-sphingosine, curated by the Drug Sig (more detail) 34 25990557 Homo sapiens
MOX013261
Genes associated with Computational Drug Signature kaempferol Genes associated with Computational Drug Signature kaempferol, curated by the Drug Signature Databas (more detail) 34 25990557 Homo sapiens
FOX000838
Genes in the cancer module 80 (more detail) 32 NA Homo sapiens
MOX013134
Genes associated with Computational Drug Signature indirubin deriv. 7a Genes associated with Computational Drug Signature indirubin deriv. 7a, curated by the Drug Signatur (more detail) 32 25990557 Homo sapiens
WAG000447
Alpha synuclein signaling (more detail) 22 NA Homo sapiens
TAX022907
GO:0035510 biological process DNA dealkylation The removal of an alkyl group from one or more nucleotides within an DNA molecule. (more detail) 22 NA Homo sapiens
MOX004445
Genes associated with Computational Drug Signature OLEANOLIC ACID Genes associated with Computational Drug Signature OLEANOLIC ACID, curated by the Drug Signature Dat (more detail) 30 25990557 Homo sapiens
WIG000018
ATM pathway (more detail) 30 NA Homo sapiens
TAX025121
GO:0045505 molecular function dynein intermediate chain binding Interacting selectively and non-covalently with an intermediate chain of the dynein complex. (more detail) 28 NA Homo sapiens
TAX017129
GO:0008209 biological process androgen metabolic process The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the (more detail) 28 NA Homo sapiens
MOX001067
Genes associated with Computational Drug Signature 4 Nitrophenol Genes associated with Computational Drug Signature 4-Nitrophenol, curated by the Drug Signature Data (more detail) 24 25990557 Homo sapiens
MEX000557
Genes associated with Approved Drug etoposide Genes associated with Approved Drug etoposide, curated by the Drug Signature Database (DSigDB). (more detail) 24 25990557 Homo sapiens
TAX000142
Genes annotated by the GO term GO:0016569. The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. (more detail) 24 NA Homo sapiens
WAG000846
proteasome complex Attachment of the ubiquitin peptide to proteins targets them for proteolytic degradation by a comple (more detail) 24 NA Homo sapiens
MOX001135
Genes associated with Computational Drug Signature HEXANE Genes associated with Computational Drug Signature HEXANE, curated by the Drug Signature Database (D (more detail) 24 25990557 Homo sapiens
MOX011953
Genes associated with Computational Drug Signature CI 1040 Genes associated with Computational Drug Signature CI-1040, curated by the Drug Signature Database ( (more detail) 24 25990557 Homo sapiens
TAX016378
GO:0006506 biological process GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GP (more detail) 24 NA Homo sapiens
TAX025418
GO:0046058 biological process cAMP metabolic process The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclo (more detail) 24 NA Homo sapiens
TAX023835
GO:0042430 biological process indole containing compound metabolic process The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) sk (more detail) 24 NA Homo sapiens
TAX022369
GO:0034204 biological process lipid translocation The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the o (more detail) 24 NA Homo sapiens
TAX030738
GO:0097194 biological process execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the a (more detail) 26 NA Homo sapiens
WIG000136
p38 MAPK signaling pathway (more detail) 26 NA Homo sapiens
TAX000966
Genes annotated by the GO term GO:0005746. The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I, III and IV can transport protons if embedded in an oriented membrane, such as an intact mitochondrial inner membrane. (more detail) 26 NA Homo sapiens
MOX003680
Genes associated with Computational Drug Signature androstenedione Genes associated with Computational Drug Signature androstenedione, curated by the Drug Signature Da (more detail) 26 25990557 Homo sapiens
TAX019557
GO:0018904 biological process ether metabolic process The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R (more detail) 17 NA Homo sapiens
IEI014251
Protein protein interactors of human gene TRIM46 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM46 (SwissProt ID (more detail) 17 17535438 Homo sapiens
IEI011407
Protein protein interactors of human gene RNF166 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF166 (SwissProt ID (more detail) 17 17535438 Homo sapiens
TAX017592
GO:0009200 biological process deoxyribonucleoside triphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consist (more detail) 17 NA Homo sapiens
MOX002578
Genes associated with Computational Drug Signature benzo[a]pyrene 7,8 dione Genes associated with Computational Drug Signature benzo[a]pyrene-7,8-dione, curated by the Drug Sig (more detail) 17 25990557 Homo sapiens
WIG001165
Genes involved in RNA Polymerase III Chain Elongation (more detail) 17 NA Homo sapiens
WIG001156
Genes involved in Resolution of AP sites via the multiple nucleotide patch replacement pathway (more detail) 17 NA Homo sapiens
FOX000658
Genes in the cancer module 346 (more detail) 17 NA Homo sapiens
WIG001253
Genes involved in Synthesis of PIPs at the Golgi membrane (more detail) 17 NA Homo sapiens
MOX000172
Genes associated with Computational Drug Signature ferulic acid Genes associated with Computational Drug Signature ferulic acid, curated by the Drug Signature Datab (more detail) 17 25990557 Homo sapiens
TAX001082
Genes annotated by the GO term GO:0016209. Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. (more detail) 17 NA Homo sapiens
TAX017309
GO:0008499 molecular function UDP galactose:beta N acetylglucosamine beta 1,3 galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosam (more detail) 14 NA Homo sapiens
TAX019385
GO:0017110 molecular function nucleoside diphosphatase activity Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. (more detail) 14 NA Homo sapiens
TAX017153
GO:0008252 molecular function nucleotidase activity Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. (more detail) 14 NA Homo sapiens
TAX017515
GO:0009113 biological process purine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two (more detail) 14 NA Homo sapiens
TAX019705
GO:0019377 biological process glycolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-ac (more detail) 14 NA Homo sapiens
TAX019085
GO:0016540 biological process protein autoprocessing Processing which a protein carries out itself. This involves actions such as the autolytic removal o (more detail) 14 NA Homo sapiens
TAX014793
GO:0003796 molecular function lysozyme activity Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D- (more detail) 14 NA Homo sapiens
TAX017871
GO:0010181 molecular function FMN binding Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) (more detail) 14 NA Homo sapiens
TAX017511
GO:0009109 biological process coenzyme catabolic process The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprote (more detail) 14 NA Homo sapiens
TAX017528
GO:0009130 biological process pyrimidine nucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphat (more detail) 14 NA Homo sapiens
TAX016401
GO:0006534 biological process cysteine metabolic process The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. (more detail) 14 NA Homo sapiens
TAX015333
GO:0004707 molecular function MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphoryla (more detail) 14 NA Homo sapiens
TAX021563
GO:0032454 molecular function histone demethylase activity (H3 K9 specific) Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = s (more detail) 14 NA Homo sapiens
TAX019608
GO:0019104 molecular function DNA N glycosylase activity Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target d (more detail) 14 NA Homo sapiens
TAX019632
GO:0019206 molecular function nucleoside kinase activity Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. (more detail) 14 NA Homo sapiens
TAX025821
GO:0046940 biological process nucleoside monophosphate phosphorylation The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a (more detail) 14 NA Homo sapiens
TAX022018
GO:0033177 cellular component proton transporting two sector ATPase complex, proton transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out (more detail) 14 NA Homo sapiens
TAX026437
GO:0050321 molecular function tau protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. (more detail) 14 NA Homo sapiens
TAX025533
GO:0046348 biological process amino sugar catabolic process The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing (more detail) 14 NA Homo sapiens
TAX022133
GO:0033549 molecular function MAP kinase phosphatase activity Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. (more detail) 14 NA Homo sapiens
TAX019700
GO:0019372 biological process lipoxygenase pathway The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or (more detail) 14 NA Homo sapiens
TAX025406
GO:0046036 biological process CTP metabolic process The chemical reactions and pathways involving CTP, cytidine triphosphate. (more detail) 14 NA Homo sapiens
TAX025532
GO:0046341 biological process CDP diacylglycerol metabolic process The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substanc (more detail) 14 NA Homo sapiens
TAX015222
GO:0004559 molecular function alpha mannosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides (more detail) 14 NA Homo sapiens
TAX016205
GO:0006241 biological process CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. (more detail) 14 NA Homo sapiens
TAX015745
GO:0005388 molecular function calcium transporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 14 NA Homo sapiens
WEX000006
Arginine Metabolism The genes related to arginine metabolism (metabolism) in tumor, immune, stroma using next-generation (more detail) 14 NA Homo sapiens
TAX025616
GO:0046519 biological process sphingoid metabolic process The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sph (more detail) 14 NA Homo sapiens
TAX017605
GO:0009214 biological process cyclic nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide (more detail) 14 NA Homo sapiens
TAX022795
GO:0035269 biological process protein O linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl (more detail) 14 NA Homo sapiens
MEX002228
Genes associated with Kinase Inhibitor Kinome 3196 Genes associated with Kinase Inhibitor Kinome_3196, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX001964
Genes associated with Kinase Inhibitor Kinome 859 Genes associated with Kinase Inhibitor Kinome_859, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
FOX000747
Genes in the cancer module 464 (more detail) 14 NA Homo sapiens
WIG000982
Genes involved in Metabolism of porphyrins (more detail) 14 NA Homo sapiens
WIG000676
Genes involved in Acyl chain remodelling of PI (more detail) 14 NA Homo sapiens
TAX001142
Genes annotated by the GO term GO:0003887. Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. (more detail) 14 NA Homo sapiens
MOX006556
Genes associated with Computational Drug Signature AC1NRCGS Genes associated with Computational Drug Signature AC1NRCGS, curated by the Drug Signature Database (more detail) 14 25990557 Homo sapiens
WIG001041
Genes involved in N Glycan antennae elongation (more detail) 14 NA Homo sapiens
MEX002269
Genes associated with Kinase Inhibitor 841290 80 0 Genes associated with Kinase Inhibitor 841290-80-0, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002283
Genes associated with Kinase Inhibitor Kinome 708 Genes associated with Kinase Inhibitor Kinome_708, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX001718
Genes associated with Kinase Inhibitor Kinome 450 Genes associated with Kinase Inhibitor Kinome_450, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
FOX000464
Genes in the cancer module 132 (more detail) 14 NA Homo sapiens
WIG000981
Genes involved in Metabolism of polyamines (more detail) 14 NA Homo sapiens
PEX002210
Pro isomerase: Cyclophilin type peptidyl prolyl cis trans isomerase/CLD The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 (more detail) 14 NA Homo sapiens
WAG000617
Fatty acid biosynthesis (more detail) 14 NA Homo sapiens
WAG001623
alpha Linolenic acid metabolism (more detail) 14 NA Homo sapiens
MEX001709
Genes associated with Kinase Inhibitor Kinome 1216 Genes associated with Kinase Inhibitor Kinome_1216, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002083
Genes associated with Kinase Inhibitor Go 6976 Genes associated with Kinase Inhibitor Go 6976, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX001207
Genes associated with Kinase Inhibitor Kinome 439 Genes associated with Kinase Inhibitor Kinome_439, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
TAX001127
Genes annotated by the GO term GO:0004112. Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. (more detail) 14 NA Homo sapiens
WIG000530
Glycosaminoglycan biosynthesis keratan sulfate (more detail) 14 NA Homo sapiens
MEX000096
Genes associated with Approved Drug dichlorphenamide Genes associated with Approved Drug dichlorphenamide, curated by the Drug Signature Database (DSigDB (more detail) 14 25990557 Homo sapiens
MEX001945
Genes associated with Kinase Inhibitor Kinome 239 Genes associated with Kinase Inhibitor Kinome_239, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX001731
Genes associated with Kinase Inhibitor TCMDC 141371 Genes associated with Kinase Inhibitor TCMDC-141371, curated by the Drug Signature Database (DSigDB) (more detail) 14 25990557 Homo sapiens
MEX002082
Genes associated with Kinase Inhibitor GW795493X Genes associated with Kinase Inhibitor GW795493X, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002123
Genes associated with Kinase Inhibitor Fostamatinib Genes associated with Kinase Inhibitor Fostamatinib, curated by the Drug Signature Database (DSigDB) (more detail) 14 25990557 Homo sapiens
TAX000236
Genes annotated by the GO term GO:0009064. The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. (more detail) 14 NA Homo sapiens
WIG001256
Genes involved in Synthesis of substrates in N glycan biosythesis (more detail) 14 NA Homo sapiens
WIG000677
Genes involved in Acyl chain remodelling of PS (more detail) 14 NA Homo sapiens
WAG001004
Ascorbate and aldarate metabolism (more detail) 14 NA Homo sapiens
WAG000403
Fatty acid elongation in mitochondria (more detail) 14 NA Homo sapiens
WAG000405
Keratan sulfate biosynthesis Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, (more detail) 14 NA Homo sapiens
WIG000611
Riboflavin metabolism (more detail) 14 NA Homo sapiens
FOX000669
Genes in the cancer module 360 (more detail) 14 NA Homo sapiens
PEX001911
Sulfotransfer 1: Sulfotransferase domain (more detail) 14 NA Homo sapiens
WAG000802
N Glycan degradation (more detail) 14 NA Homo sapiens
MEX001428
Genes associated with Kinase Inhibitor Imatinib Genes associated with Kinase Inhibitor Imatinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002015
Genes associated with Kinase Inhibitor BS 181 Genes associated with Kinase Inhibitor BS-181, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002361
Genes associated with Kinase Inhibitor CHEMBL495696 Genes associated with Kinase Inhibitor CHEMBL495696, curated by the Drug Signature Database (DSigDB) (more detail) 14 25990557 Homo sapiens
MEX002375
Genes associated with Kinase Inhibitor dorsomorphin Genes associated with Kinase Inhibitor dorsomorphin, curated by the Drug Signature Database (DSigDB) (more detail) 14 25990557 Homo sapiens
MEX002411
Genes associated with Kinase Inhibitor Imatinib Genes associated with Kinase Inhibitor Imatinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
FOX000435
Genes in the cancer module 106 (more detail) 14 NA Homo sapiens
WIG001257
Genes involved in Synthesis of very long chain fatty acyl CoAs (more detail) 14 NA Homo sapiens
WIG000838
Genes involved in FGFR1 ligand binding and activation (more detail) 14 NA Homo sapiens
WAG000510
Polymerase switching on the C strand of the telomere (more detail) 14 NA Homo sapiens
TAX001109
Genes annotated by the GO term GO:0016831. Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. (more detail) 14 NA Homo sapiens
MEX002204
Genes associated with Kinase Inhibitor curcumin Genes associated with Kinase Inhibitor curcumin, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002135
Genes associated with Kinase Inhibitor Bisindolylmaleimide XI, HCl Genes associated with Kinase Inhibitor Bisindolylmaleimide XI, HCl, curated by the Drug Signature Da (more detail) 14 25990557 Homo sapiens
MOX007338
Genes associated with Computational Drug Signature BMS 536924 Genes associated with Computational Drug Signature BMS-536924, curated by the Drug Signature Databas (more detail) 14 25990557 Homo sapiens
WIG000783
Genes involved in Cytosolic sulfonation of small molecules (more detail) 14 NA Homo sapiens
TAX013251
GO:0000098 biological process sulfur amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, com (more detail) 14 NA Homo sapiens
MOX013208
Genes associated with Computational Drug Signature Isoquercitrin Genes associated with Computational Drug Signature Isoquercitrin, curated by the Drug Signature Data (more detail) 14 25990557 Homo sapiens
MEX002412
Genes associated with Kinase Inhibitor Tofacitinib Genes associated with Kinase Inhibitor Tofacitinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002415
Genes associated with Kinase Inhibitor Ceritinib Genes associated with Kinase Inhibitor Ceritinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
WAG001539
Polymerase switching (more detail) 14 NA Homo sapiens
MEX002419
Genes associated with Kinase Inhibitor Ibrutinib Genes associated with Kinase Inhibitor Ibrutinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MEX002094
Genes associated with Kinase Inhibitor Tasocitinib Genes associated with Kinase Inhibitor Tasocitinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
WIG000533
Glycosphingolipid biosynthesis globo series (more detail) 14 NA Homo sapiens
TAX001136
Genes annotated by the GO term GO:0019239. Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). (more detail) 14 NA Homo sapiens
WIG001410
Irinotecan Pathway, Pharmacodynamics Model non-tissue specific cancer cell displaying genes which may be involved in the irinotecan pathw (more detail) 14 NA Homo sapiens
WIG001419
Ifosfamide Pathway, Pharmacodynamics Model non-tissue specific cancer cell displaying genes which may be involved in the ifosfamide pathw (more detail) 14 NA Homo sapiens
MEX001318
Genes associated with Kinase Inhibitor Ibrutinib Genes associated with Kinase Inhibitor Ibrutinib, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
TAX017496
GO:0009084 biological process glutamine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the glutamine famil (more detail) 19 NA Homo sapiens
TAX015963
GO:0005839 cellular component proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. (more detail) 19 NA Homo sapiens
FOX000731
Genes in the cancer module 440 (more detail) 19 NA Homo sapiens
WIG000468
alpha Linolenic acid metabolism (more detail) 19 NA Homo sapiens
WIG001970
Nucleotide Metabolism Nucleotide Metabolism (more detail) 19 NA Homo sapiens
WIG001109
Genes involved in Prostacyclin signalling through prostacyclin receptor (more detail) 19 NA Homo sapiens
WAG001302
Formation of the HIV 1 Early Elongation Complex (more detail) 31 NA Homo sapiens
MEX000765
Genes associated with Approved Drug methotrexate Genes associated with Approved Drug methotrexate, curated by the Drug Signature Database (DSigDB). (more detail) 31 25990557 Homo sapiens
WAG001499
Formation of the Early Elongation Complex (more detail) 31 NA Homo sapiens
WAG001111
HIV 1 Transcription Elongation (more detail) 31 NA Homo sapiens
TAX016225
GO:0006278 biological process RNA dependent DNA biosynthetic process A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. rever (more detail) 31 NA Homo sapiens
IEI004368
Protein protein interactors of human gene EXOSC7 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EXOSC7 (SwissProt ID (more detail) 31 17535438 Homo sapiens
TAX027065
GO:0051568 biological process histone H3 K4 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of t (more detail) 29 NA Homo sapiens
MOX013135
Genes associated with Computational Drug Signature INDIRUBIN 3' MONOXIME Genes associated with Computational Drug Signature INDIRUBIN-3'-MONOXIME, curated by the Drug Signat (more detail) 29 25990557 Homo sapiens
MEX000168
Genes associated with Approved Drug amrinone Genes associated with Approved Drug amrinone, curated by the Drug Signature Database (DSigDB). (more detail) 29 25990557 Homo sapiens
WIG000957
Genes involved in Keratan sulfate/keratin metabolism (more detail) 29 NA Homo sapiens
WIG001719
UVB Induced MAPK Signaling UVB-Induced MAPK Signaling (more detail) 29 NA Homo sapiens
MOX000976
Genes associated with Computational Drug Signature 2 methoxy 13 methyl 6,7,8,9,11,12,14,15,16,17 decahydrocyclopenta[a]phenanthrene 3,17 diol Genes associated with Computational Drug Signature 2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-dec (more detail) 29 25990557 Homo sapiens
IEI005481
Protein protein interactors of human gene GRB14 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GRB14 (SwissProt ID= (more detail) 21 17535438 Homo sapiens
IEI003206
Protein protein interactors of human gene CYB5A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CYB5A (SwissProt ID= (more detail) 21 17535438 Homo sapiens
TAX023904
GO:0042573 biological process retinoic acid metabolic process The chemical reactions and pathways involving retinoic acid, one of the three components that makes (more detail) 21 NA Homo sapiens
TAX021234
GO:0031935 biological process regulation of chromatin silencing Any process that affects the rate, extent or location of chromatin silencing. (more detail) 21 NA Homo sapiens
TAX023689
GO:0042135 biological process neurotransmitter catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of substances that (more detail) 21 NA Homo sapiens
TAX016174
GO:0006182 biological process cGMP biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosph (more detail) 21 NA Homo sapiens
TAX021380
GO:0032201 biological process telomere maintenance via semi conservative replication The process in which telomeric DNA is synthesized semi-conservatively by the conventional replicatio (more detail) 21 NA Homo sapiens
WIG000164
S1P1 pathway (more detail) 21 NA Homo sapiens
MOX006598
Genes associated with Computational Drug Signature acetate Genes associated with Computational Drug Signature acetate, curated by the Drug Signature Database ( (more detail) 21 25990557 Homo sapiens
WIG000736
Genes involved in CD28 dependent PI3K/Akt signaling (more detail) 21 NA Homo sapiens
MOX000751
Genes associated with Computational Drug Signature 2,6 DICHLORO 4 NITROPHENOL Genes associated with Computational Drug Signature 2,6-DICHLORO-4-NITROPHENOL, curated by the Drug S (more detail) 21 25990557 Homo sapiens
MOX015996
Genes associated with Computational Drug Signature 2 ketoglutaric acid Genes associated with Computational Drug Signature 2-ketoglutaric acid, curated by the Drug Signatur (more detail) 27 25990557 Homo sapiens
FOX000556
Genes in the cancer module 226 (more detail) 27 NA Homo sapiens
WIG000920
Genes involved in Interleukin receptor SHC signaling (more detail) 27 NA Homo sapiens
WIG000294
Transcription factor CREB and its extracellular signals The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcriptio (more detail) 27 NA Homo sapiens
FOX000633
Genes in the cancer module 318 (more detail) 27 NA Homo sapiens
IEI008389
Protein protein interactors of human gene MUL1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MUL1 (SwissProt ID=Q (more detail) 27 17535438 Homo sapiens
MOX004388
Genes associated with Computational Drug Signature nadide Genes associated with Computational Drug Signature nadide, curated by the Drug Signature Database (D (more detail) 23 25990557 Homo sapiens
MOX015671
Genes associated with Computational Drug Signature Tyrphostin B42 Genes associated with Computational Drug Signature Tyrphostin B42, curated by the Drug Signature Dat (more detail) 23 25990557 Homo sapiens
TAX000260
Genes annotated by the GO term GO:0016570. The covalent alteration of one or more amino acid residues within a histone protein. (more detail) 23 NA Homo sapiens
TAX000734
Genes annotated by the GO term GO:0006401. The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5' phosphodiester linkage. (more detail) 23 NA Homo sapiens
WAG000831
fmlp induced chemokine gene expression in hmc 1 cells Neutrophils respond to bacterial infection by releasing reactive oxygen species that kill bacteria a (more detail) 23 NA Homo sapiens
MEX000207
Genes associated with Approved Drug 5 aminosalicylic acid Genes associated with Approved Drug 5-aminosalicylic acid, curated by the Drug Signature Database (D (more detail) 23 25990557 Homo sapiens
TAX022279
GO:0034035 biological process purine ribonucleoside bisphosphate metabolic process The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consi (more detail) 23 NA Homo sapiens
TAX026447
GO:0050427 biological process 3' phosphoadenosine 5' phosphosulfate metabolic process The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occ (more detail) 23 NA Homo sapiens
TAX016381
GO:0006509 biological process membrane protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular do (more detail) 23 NA Homo sapiens
TAX019487
GO:0018198 biological process peptidyl cysteine modification The modification of peptidyl-cysteine. (more detail) 23 NA Homo sapiens
TAX017584
GO:0009190 biological process cyclic nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide (more detail) 25 NA Homo sapiens
TAX032937
GO:1903409 biological process reactive oxygen species biosynthetic process The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molec (more detail) 25 NA Homo sapiens
TAX016535
GO:0006693 biological process prostaglandin metabolic process The chemical reactions and pathways involving prostaglandins, any of a group of biologically active (more detail) 25 NA Homo sapiens
TAX016534
GO:0006692 biological process prostanoid metabolic process The chemical reactions and pathways involving prostanoids, any compound based on or derived from the (more detail) 25 NA Homo sapiens
TAX027419
GO:0052652 biological process cyclic purine nucleotide metabolic process The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phospha (more detail) 25 NA Homo sapiens
WAG001239
influence of ras and rho proteins on g1 to s transition The cell cycle transition from G1 to S phase is a key regulatory point in the cell cycle. This tran (more detail) 25 NA Homo sapiens
WAG000650
bioactive peptide induced signaling pathway Many different peptides act as sigling molecules, including the proinflammatory peptide bradykinin, (more detail) 25 NA Homo sapiens
TAX001049
Genes annotated by the GO term GO:0000151. A protein complex that includes a ubiquitin protein ligase (E3) and other proteins that may confer substrate specificity on the complex. (more detail) 25 NA Homo sapiens
TAX000446
Genes annotated by the GO term GO:0006730. The chemical reactions and pathways involving compounds containing a single carbon atom. (more detail) 25 NA Homo sapiens
MOX013248
Genes associated with Computational Drug Signature juglone Genes associated with Computational Drug Signature juglone, curated by the Drug Signature Database ( (more detail) 25 25990557 Homo sapiens
MOX001246
Genes associated with Computational Drug Signature 2 Propenoicacid, 3 phenyl Genes associated with Computational Drug Signature 2-Propenoicacid, 3-phenyl-, curated by the Drug S (more detail) 16 25990557 Homo sapiens
MEX000018
Genes associated with Approved Drug acetazolamide Genes associated with Approved Drug acetazolamide, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
MAX001962
Tricarboxylic acid related genes; based on literature and sequence annotation resources and converted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 16 NA Homo sapiens
WIG000691
Genes involved in Amino acid synthesis and interconversion (transamination) (more detail) 16 NA Homo sapiens
FOX000700
Genes in the cancer module 401 (more detail) 16 NA Homo sapiens
MEX003101
Genes associated with Perturbagen Signature dyclonine Genes associated with Perturbagen Signature dyclonine, curated by the Drug Signature Database (DSigD (more detail) 16 25990557 Homo sapiens
TAX001165
Genes annotated by the GO term GO:0008378. Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. (more detail) 16 NA Homo sapiens
MOX015798
Genes associated with Computational Drug Signature Ursolic acid Genes associated with Computational Drug Signature Ursolic acid, curated by the Drug Signature Datab (more detail) 16 25990557 Homo sapiens
TAX001186
Genes annotated by the GO term GO:0004402. Catalysis of the reaction: acetyl CoA + histone = CoA + acetyl histone. (more detail) 16 NA Homo sapiens
WIG001962
Mitochondrial LC Fatty Acid Beta Oxidation Mitochondrial LC-Fatty Acid Beta-Oxidation (more detail) 16 NA Homo sapiens
WAG001358
Synthesis of glycosylphosphatidylinositol (GPI) (more detail) 16 NA Homo sapiens
TAX000092
Genes annotated by the GO term GO:0044264. The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. (more detail) 16 NA Homo sapiens
WIG000042
DNA PK pathway in nonhomologous end joining (more detail) 16 NA Homo sapiens
TAX025530
GO:0046339 biological process diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R (more detail) 16 NA Homo sapiens
TAX016519
GO:0006677 biological process glycosylceramide metabolic process The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacem (more detail) 16 NA Homo sapiens
TAX016411
GO:0006544 biological process glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. (more detail) 16 NA Homo sapiens
TAX015976
GO:0005858 cellular component axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjace (more detail) 16 NA Homo sapiens
TAX018435
GO:0015012 biological process heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, (more detail) 16 NA Homo sapiens
TAX030179
GO:0080111 biological process DNA demethylation The removal of a methyl group from one or more nucleotides within an DNA molecule. (more detail) 16 NA Homo sapiens
TAX016113
GO:0006071 biological process glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, vi (more detail) 18 NA Homo sapiens
TAX016443
GO:0006577 biological process amino acid betaine metabolic process The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino ac (more detail) 18 NA Homo sapiens
WIG000989
Genes involved in MicroRNA (miRNA) Biogenesis (more detail) 18 NA Homo sapiens
FEX001727
Liver Cox06 20genes Table 3. Gene expression profiles of lipid metabolism and lipid catabolism genes (more detail) 18 16484296 Homo sapiens
TAX001315
Genes annotated by the GO term GO:0016776. Catalysis of the transfer of a phosphorus containing group from one compound (donor) to a phosphate group (acceptor). (more detail) 18 NA Homo sapiens
MEX000802
Genes associated with Approved Drug lapatinib Genes associated with Approved Drug lapatinib, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MOX000334
Genes associated with Computational Drug Signature ERIODICTYOL Genes associated with Computational Drug Signature ERIODICTYOL, curated by the Drug Signature Databa (more detail) 18 25990557 Homo sapiens
MOX014670
Genes associated with Computational Drug Signature purvalanol A Genes associated with Computational Drug Signature purvalanol A, curated by the Drug Signature Datab (more detail) 18 25990557 Homo sapiens
MOX018079
Genes associated with Computational Drug Signature HARMINE Genes associated with Computational Drug Signature HARMINE, curated by the Drug Signature Database ( (more detail) 18 25990557 Homo sapiens
MEX000414
Genes associated with Approved Drug cytarabine Genes associated with Approved Drug cytarabine, curated by the Drug Signature Database (DSigDB). (more detail) 18 25990557 Homo sapiens
MOX013656
Genes associated with Computational Drug Signature methotrexate Genes associated with Computational Drug Signature methotrexate, curated by the Drug Signature Datab (more detail) 28 25990557 Homo sapiens
WIG000734
Genes involved in Ca dependent events (more detail) 28 NA Homo sapiens
MOX004282
Genes associated with Computational Drug Signature MANEB Genes associated with Computational Drug Signature MANEB, curated by the Drug Signature Database (DS (more detail) 28 25990557 Homo sapiens
TAX001076
Genes annotated by the GO term GO:0004177. Catalysis of the hydrolysis of N terminal amino acid residues from oligopeptides or polypeptides. (more detail) 13 NA Homo sapiens
MEX002319
Genes associated with Kinase Inhibitor Kinome 491 Genes associated with Kinase Inhibitor Kinome_491, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
WAG000544
Xenobiotics (more detail) 13 NA Homo sapiens
MOX015215
Genes associated with Computational Drug Signature SU11652 Genes associated with Computational Drug Signature SU11652, curated by the Drug Signature Database ( (more detail) 13 25990557 Homo sapiens
MEX002215
Genes associated with Kinase Inhibitor resveratrol Genes associated with Kinase Inhibitor resveratrol, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MEX002141
Genes associated with Kinase Inhibitor roscovitine Genes associated with Kinase Inhibitor roscovitine, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MOX007591
Genes associated with Computational Drug Signature CGS 27023A Genes associated with Computational Drug Signature CGS-27023A, curated by the Drug Signature Databas (more detail) 13 25990557 Homo sapiens
WIG000624
Sulfur metabolism (more detail) 13 NA Homo sapiens
WIG000990
Genes involved in Mitochondrial Fatty Acid Beta Oxidation (more detail) 13 NA Homo sapiens
TAX001130
Genes annotated by the GO term GO:0004129. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. (more detail) 13 NA Homo sapiens
PEX000151
PDEase I: 3'5' cyclic nucleotide phosphodiesterase (more detail) 13 NA Homo sapiens
MEX001688
Genes associated with Kinase Inhibitor GW575808A Genes associated with Kinase Inhibitor GW575808A, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MEX001472
Genes associated with Kinase Inhibitor PI 103 Genes associated with Kinase Inhibitor PI-103, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
WAG000886
Endogenous sterols (more detail) 13 NA Homo sapiens
TAX001103
Genes annotated by the GO term GO:0004089. Catalysis of the reaction: H2CO3 = CO2 + H2O. (more detail) 13 NA Homo sapiens
TAX001059
Genes annotated by the GO term GO:0004114. Catalysis of the reaction: nucleoside 3',5' cyclic phosphate + H2O = nucleoside 5' phosphate. (more detail) 13 NA Homo sapiens
FOX000641
Genes in the cancer module 326 (more detail) 13 NA Homo sapiens
PEX001420
Pkinase C: Protein kinase C terminal domain (more detail) 13 NA Homo sapiens
MEX001488
Genes associated with Kinase Inhibitor GSK2213727A Genes associated with Kinase Inhibitor GSK2213727A, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MOX005546
Genes associated with Computational Drug Signature 1H Pyrrole 2,5 dione, 3,4 diphenyl Genes associated with Computational Drug Signature 1H-Pyrrole-2,5-dione, 3,4-diphenyl-, curated by t (more detail) 13 25990557 Homo sapiens
MOX006679
Genes associated with Computational Drug Signature AGN PC 00BUNE Genes associated with Computational Drug Signature AGN-PC-00BUNE, curated by the Drug Signature Data (more detail) 13 25990557 Homo sapiens
WIG001797
Biosynthesis of Steroid Hormones Biosynthesis of Steroid Hormones (more detail) 13 NA Homo sapiens
MOX005545
Genes associated with Computational Drug Signature 1H Pyrrole 2,5 dione, 3,4 bis(4 methoxyphenyl) Genes associated with Computational Drug Signature 1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)-, (more detail) 13 25990557 Homo sapiens
MEX000308
Genes associated with Approved Drug sulfanilamide Genes associated with Approved Drug sulfanilamide, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MEX002003
Genes associated with Kinase Inhibitor Kinome 474 Genes associated with Kinase Inhibitor Kinome_474, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MEX001504
Genes associated with Kinase Inhibitor PKCbeta Inhibitor Genes associated with Kinase Inhibitor PKCbeta Inhibitor, curated by the Drug Signature Database (DS (more detail) 13 25990557 Homo sapiens
MEX001844
Genes associated with Kinase Inhibitor CHEMBL1999931 Genes associated with Kinase Inhibitor CHEMBL1999931, curated by the Drug Signature Database (DSigDB (more detail) 13 25990557 Homo sapiens
WIG000680
Genes involved in Adenylate cyclase inhibitory pathway (more detail) 13 NA Homo sapiens
MEX001397
Genes associated with Kinase Inhibitor AGN PC 04WTVX Genes associated with Kinase Inhibitor AGN-PC-04WTVX, curated by the Drug Signature Database (DSigDB (more detail) 13 25990557 Homo sapiens
MEX002041
Genes associated with Kinase Inhibitor Kinome 506 Genes associated with Kinase Inhibitor Kinome_506, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
FOX000577
Genes in the cancer module 25 (more detail) 13 NA Homo sapiens
WIG001091
Genes involved in Polymerase switching (more detail) 13 NA Homo sapiens
FOX000769
Genes in the cancer module 50 (more detail) 13 NA Homo sapiens
TAX001304
Genes annotated by the GO term GO:0004623. Catalysis of the reaction: phosphatidylcholine + H2O = 1 acylglycerophosphocholine + a carboxylate. (more detail) 13 NA Homo sapiens
PEX000778
ADH N: Alcohol dehydrogenase GroES like domain This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc bindi (more detail) 13 NA Homo sapiens
PEX000005
Carb anhydrase: Eukaryotic type carbonic anhydrase (more detail) 13 NA Homo sapiens
WIG001117
Genes involved in Purine salvage (more detail) 13 NA Homo sapiens
FOX000478
Genes in the cancer module 148 (more detail) 13 NA Homo sapiens
TAX001333
Genes annotated by the GO term GO:0008276. Catalysis of the transfer of a methyl group (CH3 ) to a protein. (more detail) 13 NA Homo sapiens
WAG000799
3 Chloroacrylic acid degradation (more detail) 13 NA Homo sapiens
WIG001363
Antimetabolite Pathway Folate Cycle, Pharmacodynamics Model non-tissue specific cancer cell displaying candidate genes which may be involved in the pharma (more detail) 13 NA Homo sapiens
TAX001153
Genes annotated by the GO term GO:0004521. Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. (more detail) 13 NA Homo sapiens
TAX016206
GO:0006244 biological process pyrimidine nucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compoun (more detail) 13 NA Homo sapiens
TAX028909
GO:0070402 molecular function NADPH binding Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine din (more detail) 13 NA Homo sapiens
TAX022498
GO:0034450 molecular function ubiquitin ubiquitin ligase activity Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction (more detail) 13 NA Homo sapiens
TAX022550
GO:0034595 molecular function phosphatidylinositol phosphate 5 phosphatase activity Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. (more detail) 13 NA Homo sapiens
TAX018447
GO:0015037 molecular function peptide disulfide oxidoreductase activity Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide (more detail) 13 NA Homo sapiens
TAX030744
GO:0097200 molecular function cysteine type endopeptidase activity involved in execution phase of apoptosis Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism i (more detail) 13 NA Homo sapiens
TAX024004
GO:0042761 biological process very long chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain len (more detail) 13 NA Homo sapiens
TAX017154
GO:0008253 molecular function 5' nucleotidase activity Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. (more detail) 13 NA Homo sapiens
TAX016128
GO:0006098 biological process pentose phosphate shunt The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidi (more detail) 13 NA Homo sapiens
TAX020528
GO:0030497 biological process fatty acid elongation The elongation of a fatty acid chain by the sequential addition of two-carbon units. (more detail) 13 NA Homo sapiens
TAX019267
GO:0016863 molecular function intramolecular oxidoreductase activity, transposing C=C bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are th (more detail) 13 NA Homo sapiens
TAX019251
GO:0016840 molecular function carbon nitrogen lyase activity Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond o (more detail) 13 NA Homo sapiens
TAX017147
GO:0008239 molecular function dipeptidyl peptidase activity Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. (more detail) 13 NA Homo sapiens
TAX019450
GO:0018027 biological process peptidyl lysine dimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. (more detail) 13 NA Homo sapiens
TAX019017
GO:0016423 molecular function tRNA (guanine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA contain (more detail) 13 NA Homo sapiens
TAX017825
GO:0009982 molecular function pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule (more detail) 13 NA Homo sapiens
TAX029259
GO:0071025 biological process RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs. (more detail) 13 NA Homo sapiens
TAX017253
GO:0008417 molecular function fucosyltransferase activity Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate (more detail) 13 NA Homo sapiens
TAX015906
GO:0005751 cellular component mitochondrial respiratory chain complex IV A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial r (more detail) 13 NA Homo sapiens
TAX023905
GO:0042574 biological process retinal metabolic process The chemical reactions and pathways involving retinal, a compound that plays an important role in th (more detail) 13 NA Homo sapiens
TAX024182
GO:0043142 molecular function single stranded DNA dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of singl (more detail) 13 NA Homo sapiens
TAX031998
GO:1901070 biological process guanosine containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (gu (more detail) 13 NA Homo sapiens
TAX019157
GO:0016671 molecular function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hy (more detail) 13 NA Homo sapiens
TAX024178
GO:0043138 molecular function 3' 5' DNA helicase activity Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. (more detail) 13 NA Homo sapiens
TAX021044
GO:0031543 molecular function peptidyl proline dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + s (more detail) 13 NA Homo sapiens
TAX015151
GO:0004467 molecular function long chain fatty acid CoA ligase activity Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a (more detail) 13 NA Homo sapiens
TAX017119
GO:0008195 molecular function phosphatidate phosphatase activity Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosp (more detail) 13 NA Homo sapiens
TAX017659
GO:0009313 biological process oligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with b (more detail) 13 NA Homo sapiens
TAX019337
GO:0017017 molecular function MAP kinase tyrosine/serine/threonine phosphatase activity Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/ (more detail) 13 NA Homo sapiens
TAX019771
GO:0019646 biological process aerobic electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors (more detail) 13 NA Homo sapiens
TAX018825
GO:0016024 biological process CDP diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacyl (more detail) 13 NA Homo sapiens
TAX023257
GO:0036109 biological process alpha linolenic acid metabolic process The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty aci (more detail) 13 NA Homo sapiens
TAX024199
GO:0043173 biological process nucleotide salvage Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified wi (more detail) 13 NA Homo sapiens
TAX025615
GO:0046514 biological process ceramide catabolic process The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphing (more detail) 13 NA Homo sapiens
TAX034223
GO:1990380 molecular function Lys48 specific deubiquitinase activity Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. (more detail) 13 NA Homo sapiens
TAX016149
GO:0006123 biological process mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, (more detail) 13 NA Homo sapiens
TAX019325
GO:0016998 biological process cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a (more detail) 13 NA Homo sapiens
TAX014841
GO:0003906 molecular function DNA (apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a da (more detail) 13 NA Homo sapiens
TAX015211
GO:0004535 molecular function poly(A) specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. (more detail) 13 NA Homo sapiens
TAX021932
GO:0033014 biological process tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments cont (more detail) 26 NA Homo sapiens
TAX021453
GO:0032309 biological process icosanoid secretion The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell (more detail) 26 NA Homo sapiens
TAX015592
GO:0005104 molecular function fibroblast growth factor receptor binding Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). (more detail) 26 NA Homo sapiens
MOX001260
Genes associated with Computational Drug Signature 1 NAPHTHOL Genes associated with Computational Drug Signature 1-NAPHTHOL, curated by the Drug Signature Databas (more detail) 26 25990557 Homo sapiens
MOX017660
Genes associated with Computational Drug Signature Rhodamine 123 Genes associated with Computational Drug Signature Rhodamine 123, curated by the Drug Signature Data (more detail) 26 25990557 Homo sapiens
MOX015667
Genes associated with Computational Drug Signature Tyrphostin 23 Genes associated with Computational Drug Signature Tyrphostin 23, curated by the Drug Signature Data (more detail) 26 25990557 Homo sapiens
WIG000542
Homologous recombination Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs (more detail) 26 NA Homo sapiens
MOX000942
Genes associated with Computational Drug Signature Mangostin Genes associated with Computational Drug Signature Mangostin, curated by the Drug Signature Database (more detail) 26 25990557 Homo sapiens
TAX000743
Genes annotated by the GO term GO:0019748. The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. (more detail) 26 NA Homo sapiens
TAX023286
GO:0036150 biological process phosphatidylserine acyl chain remodeling Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation re (more detail) 20 NA Homo sapiens
TAX021119
GO:0031683 molecular function G protein beta/gamma subunit complex binding Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. (more detail) 20 NA Homo sapiens
MOX004209
Genes associated with Computational Drug Signature HYPOCHLOROUS ACID Genes associated with Computational Drug Signature HYPOCHLOROUS ACID, curated by the Drug Signature (more detail) 20 25990557 Homo sapiens
WIG001595
Notch Signaling Notch Signaling (more detail) 20 NA Homo sapiens
MOX001014
Genes associated with Computational Drug Signature acacetin Genes associated with Computational Drug Signature acacetin, curated by the Drug Signature Database (more detail) 20 25990557 Homo sapiens
WIG001190
Genes involved in SHC1 events in ERBB4 signaling (more detail) 20 NA Homo sapiens
MOX006583
Genes associated with Computational Drug Signature acacetin Genes associated with Computational Drug Signature acacetin, curated by the Drug Signature Database (more detail) 20 25990557 Homo sapiens
MEX000544
Genes associated with Approved Drug doxorubicin Genes associated with Approved Drug doxorubicin, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
WIG001600
Nucleotide Excision Repair Pathway Nucleotide Excision Repair Pathway (more detail) 24 NA Homo sapiens
MOX005911
Genes associated with Computational Drug Signature 3 O Methylquercetin Genes associated with Computational Drug Signature 3-O-Methylquercetin, curated by the Drug Signatur (more detail) 24 25990557 Homo sapiens
MEX001111
Genes associated with Approved Drug carfilzomib Genes associated with Approved Drug carfilzomib, curated by the Drug Signature Database (DSigDB). (more detail) 24 25990557 Homo sapiens
FOX000208
Neighborhood of SERPINI2 Neighborhood of SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 in the GNF2 expres (more detail) 24 NA Homo sapiens
WIG001938
Signal Transduction of S1P Receptor Signal Transduction of S1P Receptor (more detail) 24 NA Homo sapiens
MOX003346
Genes associated with Computational Drug Signature Tozasertib Genes associated with Computational Drug Signature Tozasertib, curated by the Drug Signature Databas (more detail) 24 25990557 Homo sapiens
WIG000165
S1P2 pathway (more detail) 24 NA Homo sapiens
WIG000971
Genes involved in Meiotic Recombination (more detail) 24 NA Homo sapiens
IEI005342
Protein protein interactors of human gene GNS from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GNS (SwissProt ID=P1 (more detail) 24 17535438 Homo sapiens
WIG001027
Genes involved in Nitric oxide stimulates guanylate cyclase (more detail) 22 NA Homo sapiens
MEX000776
Genes associated with Approved Drug docetaxel Genes associated with Approved Drug docetaxel, curated by the Drug Signature Database (DSigDB). (more detail) 22 25990557 Homo sapiens
MOX002028
Genes associated with Computational Drug Signature gambogic acid Genes associated with Computational Drug Signature gambogic acid, curated by the Drug Signature Data (more detail) 22 25990557 Homo sapiens
MOX015586
Genes associated with Computational Drug Signature Tozasertib Genes associated with Computational Drug Signature Tozasertib, curated by the Drug Signature Databas (more detail) 22 25990557 Homo sapiens
FOX000713
Genes in the cancer module 417 (more detail) 22 NA Homo sapiens
WIG000432
Aspirin Blocks Signaling Pathway Involved in Platelet Activation Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotti (more detail) 22 NA Homo sapiens
MOX004153
Genes associated with Computational Drug Signature GLYCYRRHETINIC ACID Genes associated with Computational Drug Signature GLYCYRRHETINIC ACID, curated by the Drug Signatur (more detail) 22 25990557 Homo sapiens
TAX017655
GO:0009309 biological process amine biosynthetic process The chemical reactions and pathways resulting in the formation of any organic compound that is weakl (more detail) 22 NA Homo sapiens
WIG000821
Genes involved in Endogenous sterols (more detail) 15 NA Homo sapiens
WAG000664
Regulation of p38 alpha and p38 beta (more detail) 15 NA Homo sapiens
FOX000725
Genes in the cancer module 432 (more detail) 15 NA Homo sapiens
MOX012985
Genes associated with Computational Drug Signature HARMINE Genes associated with Computational Drug Signature HARMINE, curated by the Drug Signature Database ( (more detail) 15 25990557 Homo sapiens
WIG000532
Glycosphingolipid biosynthesis ganglio series (more detail) 15 NA Homo sapiens
TAX013560
GO:0000963 biological process mitochondrial RNA processing The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more ma (more detail) 15 NA Homo sapiens
TAX022014
GO:0033169 biological process histone H3 K9 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the his (more detail) 15 NA Homo sapiens
TAX015791
GO:0005528 molecular function FK506 binding Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. (more detail) 15 NA Homo sapiens
TAX017512
GO:0009110 biological process vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unre (more detail) 15 NA Homo sapiens
TAX015790
GO:0005527 molecular function macrolide binding Interacting selectively and non-covalently with a macrolide, any of a large group of structurally re (more detail) 15 NA Homo sapiens
TAX016220
GO:0006271 biological process DNA strand elongation involved in DNA replication The process in which a DNA strand is synthesized from template DNA during replication by the action (more detail) 15 NA Homo sapiens
TAX016369
GO:0006490 biological process oligosaccharide lipid intermediate biosynthetic process The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermedi (more detail) 15 NA Homo sapiens
TAX031691
GO:0140053 biological process mitochondrial gene expression The process in which a mitochondrial gene's sequence is converted into a mature gene product or prod (more detail) 15 NA Homo sapiens
TAX017776
GO:0009812 biological process flavonoid metabolic process The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivati (more detail) 15 NA Homo sapiens
MOX013784
Genes associated with Computational Drug Signature morin Genes associated with Computational Drug Signature morin, curated by the Drug Signature Database (DS (more detail) 27 25990557 Homo sapiens
WIG001226
Genes involved in Signalling to RAS (more detail) 27 NA Homo sapiens
WIG000724
Genes involved in Bile acid and bile salt metabolism (more detail) 27 NA Homo sapiens
TAX000234
Genes annotated by the GO term GO:0006006. The chemical reactions and pathways involving glucose, the aldohexose gluco hexose. D glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo and hetero oligosaccharides and polysaccharides. (more detail) 27 NA Homo sapiens
WIG001972
Oxidative Stress Oxidative Stress (more detail) 27 NA Homo sapiens
IEI011563
Protein protein interactors of human gene RPP38 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RPP38 (SwissProt ID= (more detail) 27 17535438 Homo sapiens
IEI008396
Protein protein interactors of human gene MVD from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MVD (SwissProt ID=P5 (more detail) 27 17535438 Homo sapiens
IEI001790
Protein protein interactors of human gene CARD11 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CARD11 (SwissProt ID (more detail) 27 17535438 Homo sapiens
TAX021019
GO:0031489 molecular function myosin V binding Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule inv (more detail) 17 NA Homo sapiens
TAX017486
GO:0009070 biological process serine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the serine family, (more detail) 17 NA Homo sapiens
TAX018810
GO:0015986 biological process ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive fo (more detail) 17 NA Homo sapiens
TAX018809
GO:0015985 biological process energy coupled proton transport, down electrochemical gradient The transport of protons across a membrane to generate an electrochemical gradient (proton-motive fo (more detail) 17 NA Homo sapiens
IEI015826
Protein protein interactors of human gene ZNRF1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ZNRF1 (SwissProt ID= (more detail) 17 17535438 Homo sapiens
IEI003978
Protein protein interactors of human gene EFNA1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EFNA1 (SwissProt ID= (more detail) 17 17535438 Homo sapiens
WIG000795
Genes involved in Destabilization of mRNA by KSRP (more detail) 17 NA Homo sapiens
MOX001945
Genes associated with Computational Drug Signature AT 877 Genes associated with Computational Drug Signature AT 877, curated by the Drug Signature Database (D (more detail) 17 25990557 Homo sapiens
WIG000794
Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) (more detail) 17 NA Homo sapiens
FEX001589
Leukemia Sanchez Guijo08 19genes SuppTable2o Genes involved in protein phosphorilation (more detail) 17 18722011 Homo sapiens
WIG001248
Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) (more detail) 17 NA Homo sapiens
MOX016316
Genes associated with Computational Drug Signature QUINACRINE DIHYDROCHLORIDE Genes associated with Computational Drug Signature QUINACRINE DIHYDROCHLORIDE, curated by the Drug S (more detail) 17 25990557 Homo sapiens
TAX013709
GO:0001573 biological process ganglioside metabolic process The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to othe (more detail) 17 NA Homo sapiens
WAG000661
p38 MAPK signaling pathway (more detail) 17 NA Homo sapiens
WIG001389
Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics Schematic representation of mycophenolic acid metabolism. (more detail) 17 NA Homo sapiens
TAX019446
GO:0018023 biological process peptidyl lysine trimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. (more detail) 25 NA Homo sapiens
TAX016249
GO:0006308 biological process DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of (more detail) 25 NA Homo sapiens
TAX013310
GO:0000217 molecular function DNA secondary structure binding Interacting selectively and non-covalently with DNA containing secondary structure elements such as (more detail) 25 NA Homo sapiens
MOX002959
Genes associated with Computational Drug Signature apicidin Genes associated with Computational Drug Signature apicidin, curated by the Drug Signature Database (more detail) 25 25990557 Homo sapiens
WIG000279
CCR3 signaling in Eosinophils Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic rea (more detail) 23 NA Homo sapiens
WIG000562
Mismatch repair DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintain (more detail) 23 NA Homo sapiens
MOX004212
Genes associated with Computational Drug Signature ifosfamide Genes associated with Computational Drug Signature ifosfamide, curated by the Drug Signature Databas (more detail) 23 25990557 Homo sapiens
MOX004879
Genes associated with Computational Drug Signature ETYA Genes associated with Computational Drug Signature ETYA, curated by the Drug Signature Database (DSi (more detail) 23 25990557 Homo sapiens
MOX001350
Genes associated with Computational Drug Signature IN1541 Genes associated with Computational Drug Signature IN1541, curated by the Drug Signature Database (D (more detail) 23 25990557 Homo sapiens
TAX026462
GO:0050482 biological process arachidonic acid secretion The controlled release of arachidonic acid from a cell or a tissue. (more detail) 23 NA Homo sapiens
TAX033225
GO:1903963 biological process arachidonate transport The directed movement of an arachidonate into, out of or within a cell, or between cells, by means o (more detail) 23 NA Homo sapiens
MOX016709
Genes associated with Computational Drug Signature Disulfides Genes associated with Computational Drug Signature Disulfides, curated by the Drug Signature Databas (more detail) 19 25990557 Homo sapiens
WIG000960
Genes involved in Lagging Strand Synthesis (more detail) 19 NA Homo sapiens
WIG001169
Genes involved in RNA Polymerase III Transcription Termination (more detail) 19 NA Homo sapiens
WAG000640
role of erk5 in neuronal survival pathway Axons extend significant distances to innervate target tissues. At the site of innervation, target (more detail) 19 NA Homo sapiens
WIG000654
Genes involved in Activated AMPK stimulates fatty acid oxidation in muscle (more detail) 19 NA Homo sapiens
TAX000097
Genes annotated by the GO term GO:0045333. The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). (more detail) 19 NA Homo sapiens
MEX000050
Genes associated with Approved Drug bumetanide Genes associated with Approved Drug bumetanide, curated by the Drug Signature Database (DSigDB). (more detail) 19 25990557 Homo sapiens
IEI011206
Protein protein interactors of human gene RFFL from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RFFL (SwissProt ID=Q (more detail) 19 17535438 Homo sapiens
IEI012263
Protein protein interactors of human gene SLA from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SLA (SwissProt ID=Q1 (more detail) 19 17535438 Homo sapiens
TAX017658
GO:0009312 biological process oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with b (more detail) 19 NA Homo sapiens
TAX023426
GO:0036508 biological process protein alpha 1,2 demannosylation The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. (more detail) 19 NA Homo sapiens
TAX023425
GO:0036507 biological process protein demannosylation The removal of one or more mannose residues from a mannosylated protein. (more detail) 19 NA Homo sapiens
TAX001134
Genes annotated by the GO term GO:0003684. Interacting selectively with damaged DNA. (more detail) 21 NA Homo sapiens
MOX000169
Genes associated with Computational Drug Signature hypericin Genes associated with Computational Drug Signature hypericin, curated by the Drug Signature Database (more detail) 21 25990557 Homo sapiens
FOX000805
Genes in the cancer module 562 (more detail) 21 NA Homo sapiens
MOX003294
Genes associated with Computational Drug Signature purvalanol A Genes associated with Computational Drug Signature purvalanol A, curated by the Drug Signature Datab (more detail) 21 25990557 Homo sapiens
MEX000017
Genes associated with Approved Drug acetaminophen Genes associated with Approved Drug acetaminophen, curated by the Drug Signature Database (DSigDB). (more detail) 21 25990557 Homo sapiens
WIG000827
Genes involved in ERK/MAPK targets (more detail) 21 NA Homo sapiens
MOX004310
Genes associated with Computational Drug Signature merbromin Genes associated with Computational Drug Signature merbromin, curated by the Drug Signature Database (more detail) 21 25990557 Homo sapiens
TAX000184
Genes annotated by the GO term GO:0006302. The repair of double strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. (more detail) 21 NA Homo sapiens
TAX023814
GO:0042401 biological process cellular biogenic amine biosynthetic process The chemical reactions and pathways occurring at the level of individual cells resulting in the form (more detail) 21 NA Homo sapiens
IEI011386
Protein protein interactors of human gene RNF125 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF125 (SwissProt ID (more detail) 21 17535438 Homo sapiens
IEI010228
Protein protein interactors of human gene POLR2K from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene POLR2K (SwissProt ID (more detail) 21 17535438 Homo sapiens
TAX032424
GO:1902224 biological process ketone body metabolic process The chemical reactions and pathways involving ketone body. (more detail) 12 NA Homo sapiens
TAX024153
GO:0043097 biological process pyrimidine nucleoside salvage Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting (more detail) 12 NA Homo sapiens
TAX019327
GO:0017000 biological process antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produce (more detail) 12 NA Homo sapiens
TAX018950
GO:0016273 molecular function arginine N methyltransferase activity Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine (more detail) 12 NA Homo sapiens
TAX017394
GO:0008655 biological process pyrimidine containing compound salvage Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide (more detail) 12 NA Homo sapiens
TAX031968
GO:1900750 molecular function oligopeptide binding Interacting selectively and non-covalently with an oligopeptide. (more detail) 12 NA Homo sapiens
TAX025469
GO:0046133 biological process pyrimidine ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside i (more detail) 12 NA Homo sapiens
TAX015032
GO:0004185 molecular function serine type carboxypeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a (more detail) 12 NA Homo sapiens
TAX016111
GO:0006068 biological process ethanol catabolic process The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, (more detail) 12 NA Homo sapiens
TAX017541
GO:0009143 biological process nucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compo (more detail) 12 NA Homo sapiens
TAX029235
GO:0070989 biological process oxidative demethylation The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. ele (more detail) 12 NA Homo sapiens
TAX017614
GO:0009223 biological process pyrimidine deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, (more detail) 12 NA Homo sapiens
TAX017523
GO:0009125 biological process nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a comp (more detail) 12 NA Homo sapiens
TAX020617
GO:0030677 cellular component ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-t (more detail) 12 NA Homo sapiens
TAX031558
GO:0106019 molecular function phosphatidylinositol 4,5 bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-my (more detail) 12 NA Homo sapiens
TAX020718
GO:0030914 cellular component STAGA complex A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation (more detail) 12 NA Homo sapiens
TAX017498
GO:0009086 biological process methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio) (more detail) 12 NA Homo sapiens
TAX016435
GO:0006568 biological process tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol- (more detail) 12 NA Homo sapiens
TAX018792
GO:0015929 molecular function hexosaminidase activity Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) re (more detail) 12 NA Homo sapiens
TAX019732
GO:0019471 biological process 4 hydroxyproline metabolic process The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino a (more detail) 12 NA Homo sapiens
TAX018951
GO:0016274 molecular function protein arginine N methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine (more detail) 12 NA Homo sapiens
TAX025721
GO:0046710 biological process GDP metabolic process The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. (more detail) 12 NA Homo sapiens
TAX016112
GO:0006069 biological process ethanol oxidation An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetat (more detail) 12 NA Homo sapiens
TAX022775
GO:0035246 biological process peptidyl arginine N methylation The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein. (more detail) 12 NA Homo sapiens
TAX025593
GO:0046479 biological process glycosphingolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with (more detail) 12 NA Homo sapiens
TAX019207
GO:0016775 molecular function phosphotransferase activity, nitrogenous group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenou (more detail) 12 NA Homo sapiens
TAX019214
GO:0016783 molecular function sulfurtransferase activity Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). (more detail) 12 NA Homo sapiens
TAX019226
GO:0016801 molecular function hydrolase activity, acting on ether bonds Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. (more detail) 12 NA Homo sapiens
TAX019285
GO:0016889 molecular function endodeoxyribonuclease activity, producing 3' phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal bre (more detail) 12 NA Homo sapiens
TAX014950
GO:0004062 molecular function aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bispho (more detail) 12 NA Homo sapiens
TAX018169
GO:0010857 molecular function calcium dependent protein kinase activity Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the pres (more detail) 12 NA Homo sapiens
TAX019149
GO:0016653 molecular function oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or el (more detail) 12 NA Homo sapiens
TAX027414
GO:0052629 molecular function phosphatidylinositol 3,5 bisphosphate 3 phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl- (more detail) 12 NA Homo sapiens
TAX020705
GO:0030898 molecular function actin dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an ac (more detail) 12 NA Homo sapiens
MEX001610
Genes associated with Kinase Inhibitor CHEMBL1965660 Genes associated with Kinase Inhibitor CHEMBL1965660, curated by the Drug Signature Database (DSigDB (more detail) 12 25990557 Homo sapiens
TAX001283
Genes annotated by the GO term GO:0016684. Catalysis of an oxidation reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. (more detail) 12 NA Homo sapiens
FEX001162
Immune Kong10 12genes ImmPort TGF betaFamilyMemberReceptors ImmPort genelist of cytokine receptors: TGF-beta Family Member Receptors (more detail) 12 20460173 Homo sapiens
WIG000839
Genes involved in FGFR2c ligand binding and activation (more detail) 12 NA Homo sapiens
WIG001148
Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex (more detail) 12 NA Homo sapiens
MEX001329
Genes associated with Kinase Inhibitor Afatinib Genes associated with Kinase Inhibitor Afatinib, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX002340
Genes associated with Kinase Inhibitor Kinome 10 Genes associated with Kinase Inhibitor Kinome_10, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001806
Genes associated with Kinase Inhibitor Vandetanib Genes associated with Kinase Inhibitor Vandetanib, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
TAX001240
Genes annotated by the GO term GO:0004707. Catalysis of the phosphorylation of proteins. Mitogen activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation or differentiation inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. (more detail) 12 NA Homo sapiens
PEX001225
NUDIX: NUDIX domain (more detail) 12 NA Homo sapiens
WAG001232
Synthesis and degradation of ketone bodies (more detail) 12 NA Homo sapiens
MEX001634
Genes associated with Kinase Inhibitor Tandutinib Genes associated with Kinase Inhibitor Tandutinib, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001775
Genes associated with Kinase Inhibitor Kinome 3513 Genes associated with Kinase Inhibitor Kinome_3513, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001816
Genes associated with Kinase Inhibitor Kinome 490 Genes associated with Kinase Inhibitor Kinome_490, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MOX004782
Genes associated with Computational Drug Signature tranylcypromine Genes associated with Computational Drug Signature tranylcypromine, curated by the Drug Signature Da (more detail) 12 25990557 Homo sapiens
WIG000840
Genes involved in FGFR4 ligand binding and activation (more detail) 12 NA Homo sapiens
FOX000593
Genes in the cancer module 272 (more detail) 12 NA Homo sapiens
FOX000701
Genes in the cancer module 402 (more detail) 12 NA Homo sapiens
MEX001913
Genes associated with Kinase Inhibitor Purvalanol B Genes associated with Kinase Inhibitor Purvalanol B, curated by the Drug Signature Database (DSigDB) (more detail) 12 25990557 Homo sapiens
MEX002294
Genes associated with Kinase Inhibitor PYRAZOLOPYRIDAZINE 1 Genes associated with Kinase Inhibitor PYRAZOLOPYRIDAZINE 1, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
MEX002367
Genes associated with Kinase Inhibitor Kinome 501 Genes associated with Kinase Inhibitor Kinome_501, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
TAX001277
Genes annotated by the GO term GO:0008170. Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. (more detail) 12 NA Homo sapiens
MEX001423
Genes associated with Kinase Inhibitor Kinome 249 Genes associated with Kinase Inhibitor Kinome_249, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX000703
Genes associated with Approved Drug brinzolamide Genes associated with Approved Drug brinzolamide, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX002002
Genes associated with Kinase Inhibitor Aurora Kinase/Cdk Inhibitor Genes associated with Kinase Inhibitor Aurora Kinase/Cdk Inhibitor, curated by the Drug Signature Da (more detail) 12 25990557 Homo sapiens
PEX001280
Methyltransf 25: Methyltransferase domain This family appears to be a methyltransferase domain. (more detail) 12 NA Homo sapiens
MEX001644
Genes associated with Kinase Inhibitor 172889 27 9 Genes associated with Kinase Inhibitor 172889-27-9, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001209
Genes associated with Kinase Inhibitor 172889 26 8 Genes associated with Kinase Inhibitor 172889-26-8, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MOX005504
Genes associated with Computational Drug Signature 153436 54 5 Genes associated with Computational Drug Signature 153436-54-5, curated by the Drug Signature Databa (more detail) 12 25990557 Homo sapiens
TAX001207
Genes annotated by the GO term GO:0004437. Catalysis of the removal of a phosphate group from phosphorylated myo inositol (1,2,3,5/4,6 cyclohexanehexol) or a phosphatidylinositol. (more detail) 12 NA Homo sapiens
TAX001232
Genes annotated by the GO term GO:0001727. Catalysis of the phosphorylation of a simple or complex lipid. (more detail) 12 NA Homo sapiens
WIG001162
Genes involved in Reversible Hydration of Carbon Dioxide (more detail) 12 NA Homo sapiens
WIG000267
Role of fl arrestins in the activation and targeting of MAP kinases The binding of -arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation (more detail) 12 NA Homo sapiens
PEX001140
GST N: Glutathione S transferase, N terminal domain Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment (more detail) 12 NA Homo sapiens
PEX000754
Peptidase M10: Matrixin The members of this family are enzymes that cleave peptides. These proteases require zinc for cataly (more detail) 12 NA Homo sapiens
MEX000972
Genes associated with Approved Drug dorzolamide Genes associated with Approved Drug dorzolamide, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001323
Genes associated with Kinase Inhibitor Tyrphostin AG 1478 Genes associated with Kinase Inhibitor Tyrphostin AG 1478, curated by the Drug Signature Database (D (more detail) 12 25990557 Homo sapiens
MEX001933
Genes associated with Kinase Inhibitor rottlerin Genes associated with Kinase Inhibitor rottlerin, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX002408
Genes associated with Kinase Inhibitor Afatinib Genes associated with Kinase Inhibitor Afatinib, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
TAX001244
Genes annotated by the GO term GO:0008235. Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. (more detail) 12 NA Homo sapiens
TAX001062
Genes annotated by the GO term GO:0008376. Catalysis of the transfer of an N acetylgalactosaminyl residue from UDP N acetyl galactosamine to an oligosaccharide. (more detail) 12 NA Homo sapiens
FOX000432
Genes in the cancer module 103 (more detail) 12 NA Homo sapiens
FOX000803
Genes in the cancer module 56 (more detail) 12 NA Homo sapiens
PEX001246
UCH: Ubiquitin carboxyl terminal hydrolase (more detail) 12 NA Homo sapiens
PEX001984
Methyltransf 11: Methyltransferase domain Members of this family are SAM dependent methyltransferases. (more detail) 12 NA Homo sapiens
MEX001427
Genes associated with Kinase Inhibitor GSK1326255A Genes associated with Kinase Inhibitor GSK1326255A, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001931
Genes associated with Kinase Inhibitor GW305178X Genes associated with Kinase Inhibitor GW305178X, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001944
Genes associated with Kinase Inhibitor GSK1173862A Genes associated with Kinase Inhibitor GSK1173862A, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
MEX001510
Genes associated with Kinase Inhibitor go 6983 Genes associated with Kinase Inhibitor go 6983, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
TAX001060
Genes annotated by the GO term GO:0008408. Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. (more detail) 12 NA Homo sapiens
MEX001992
Genes associated with Kinase Inhibitor bisindolylmaleimide i Genes associated with Kinase Inhibitor bisindolylmaleimide i, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
MOX001304
Genes associated with Computational Drug Signature Benzo[a]pyrene 1,6 dione Genes associated with Computational Drug Signature Benzo[a]pyrene-1,6-dione, curated by the Drug Sig (more detail) 14 25990557 Homo sapiens
TAX000931
Genes annotated by the GO term GO:0005871. Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. (more detail) 14 NA Homo sapiens
WAG001326
MicroRNA biogenesis (more detail) 14 NA Homo sapiens
MOX010842
Genes associated with Computational Drug Signature CHEMBL475540 Genes associated with Computational Drug Signature CHEMBL475540, curated by the Drug Signature Datab (more detail) 14 25990557 Homo sapiens
MOX017039
Genes associated with Computational Drug Signature carbidopa Genes associated with Computational Drug Signature carbidopa, curated by the Drug Signature Database (more detail) 14 25990557 Homo sapiens
MOX012560
Genes associated with Computational Drug Signature ERIODICTYOL Genes associated with Computational Drug Signature ERIODICTYOL, curated by the Drug Signature Databa (more detail) 14 25990557 Homo sapiens
WIG001315
Genes involved in Viral Messenger RNA Synthesis (more detail) 14 NA Homo sapiens
FOX000651
Genes in the cancer module 335 (more detail) 14 NA Homo sapiens
WIG001402
Abacavir Pathway, Pharmacokinetics/Pharmacodynamics Schematic representation of abacavir metabolism and mechanism of action. The potential mechanism of (more detail) 14 NA Homo sapiens
MAX002048
Composition of the 2 MDa human STAGA complex containing KAT2A [GeneID=2648] . Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific transcriptional (more detail) 14 NA Homo sapiens
WIG001769
Base Excision Repair Pathway Base Excision Repair Pathway (more detail) 14 NA Homo sapiens
TAX019741
GO:0019511 biological process peptidyl proline hydroxylation The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. (more detail) 14 NA Homo sapiens
TAX016526
GO:0006684 biological process sphingomyelin metabolic process The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholi (more detail) 14 NA Homo sapiens
TAX016093
GO:0006047 biological process UDP N acetylglucosamine metabolic process The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-ace (more detail) 14 NA Homo sapiens
TAX016367
GO:0006488 biological process dolichol linked oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, u (more detail) 14 NA Homo sapiens
TAX025607
GO:0046500 biological process S adenosylmethionine metabolic process The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an (more detail) 14 NA Homo sapiens
IEI005115
Protein protein interactors of human gene GCM1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GCM1 (SwissProt ID=Q (more detail) 14 17535438 Homo sapiens
TAX015902
GO:0005746 cellular component mitochondrial respiratory chain The protein complexes that form the mitochondrial electron transport system (the respiratory chain), (more detail) 14 NA Homo sapiens
MOX012891
Genes associated with Computational Drug Signature GNF Pf 3464 Genes associated with Computational Drug Signature GNF-Pf-3464, curated by the Drug Signature Databa (more detail) 24 25990557 Homo sapiens
WIG001176
Genes involved in RNA Polymerase I Transcription Initiation (more detail) 24 NA Homo sapiens
WIG001035
Genes involved in Nuclear Events (kinase and transcription factor activation) (more detail) 24 NA Homo sapiens
MOX001029
Genes associated with Computational Drug Signature Cryptolepine Genes associated with Computational Drug Signature Cryptolepine, curated by the Drug Signature Datab (more detail) 24 25990557 Homo sapiens
WIG000329
Cell Cycle: G2/M Checkpoint The G2/M DNA damage checkpoint prevents the cell from entering mitosis (M phase) if the genome is da (more detail) 24 NA Homo sapiens
MOX005317
Genes associated with Computational Drug Signature 1,2 NAPHTHOQUINONE Genes associated with Computational Drug Signature 1,2-NAPHTHOQUINONE, curated by the Drug Signature (more detail) 24 25990557 Homo sapiens
FEX003493
Viral Cairo08 25genes Table S5. Overrepresented pathways (p (more detail) 24 19061838 Homo sapiens
IEI004326
Protein protein interactors of human gene ETV1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ETV1 (SwissProt ID=P (more detail) 24 17535438 Homo sapiens
IEI012134
Protein protein interactors of human gene SH2B2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SH2B2 (SwissProt ID= (more detail) 24 17535438 Homo sapiens
IEI003819
Protein protein interactors of human gene DTX1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DTX1 (SwissProt ID=Q (more detail) 24 17535438 Homo sapiens
IEI009698
Protein protein interactors of human gene PDK1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PDK1 (SwissProt ID=Q (more detail) 24 17535438 Homo sapiens
TAX019032
GO:0016447 biological process somatic recombination of immunoglobulin gene segments The process in which immunoglobulin genes are formed through recombination of the germline genetic e (more detail) 24 NA Homo sapiens
TAX026040
GO:0048038 molecular function quinone binding Interacting selectively and non-covalently with a quinone, any member of a class of diketones deriva (more detail) 16 NA Homo sapiens
TAX016215
GO:0006266 biological process DNA ligation The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. (more detail) 16 NA Homo sapiens
TAX020501
GO:0030397 biological process membrane disassembly The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. (more detail) 16 NA Homo sapiens
TAX023906
GO:0042575 cellular component DNA polymerase complex A protein complex that possesses DNA polymerase activity and is involved in template directed synthe (more detail) 16 NA Homo sapiens
IEI001335
Protein protein interactors of human gene BICD2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene BICD2 (SwissProt ID= (more detail) 16 17535438 Homo sapiens
TAX019500
GO:0018216 biological process peptidyl arginine methylation The addition of a methyl group to an arginine residue in a protein. (more detail) 16 NA Homo sapiens
TAX026778
GO:0051081 biological process nuclear envelope disassembly The controlled breakdown of the nuclear envelope in the context of a normal process. (more detail) 16 NA Homo sapiens
WIG001374
Carbamazepine Pathway, Pharmacokinetics Stylized liver cell depicting candidate genes involved in the pharmacokinetics of carbamazepine. (more detail) 16 NA Homo sapiens
TAX013338
GO:0000272 biological process polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of man (more detail) 16 NA Homo sapiens
WIG001513
G Protein Signaling through Tubby Protein G-Protein Signaling through Tubby Protein (more detail) 16 NA Homo sapiens
MOX002183
Genes associated with Computational Drug Signature 3,5 dinitrocatechol Genes associated with Computational Drug Signature 3,5-dinitrocatechol, curated by the Drug Signatur (more detail) 16 25990557 Homo sapiens
MOX001547
Genes associated with Computational Drug Signature trequinsin Genes associated with Computational Drug Signature trequinsin, curated by the Drug Signature Databas (more detail) 16 25990557 Homo sapiens
MOX003367
Genes associated with Computational Drug Signature Lapatinib Genes associated with Computational Drug Signature Lapatinib, curated by the Drug Signature Database (more detail) 16 25990557 Homo sapiens
MOX004175
Genes associated with Computational Drug Signature HARMINE Genes associated with Computational Drug Signature HARMINE, curated by the Drug Signature Database ( (more detail) 16 25990557 Homo sapiens
MOX000852
Genes associated with Computational Drug Signature benzo[a]pyrene 3,6 dione Genes associated with Computational Drug Signature benzo[a]pyrene-3,6-dione, curated by the Drug Sig (more detail) 16 25990557 Homo sapiens
MOX004223
Genes associated with Computational Drug Signature iodoacetamide Genes associated with Computational Drug Signature iodoacetamide, curated by the Drug Signature Data (more detail) 22 25990557 Homo sapiens
MOX001128
Genes associated with Computational Drug Signature Oltipraz Genes associated with Computational Drug Signature Oltipraz, curated by the Drug Signature Database (more detail) 22 25990557 Homo sapiens
MOX004645
Genes associated with Computational Drug Signature scopoletin Genes associated with Computational Drug Signature scopoletin, curated by the Drug Signature Databas (more detail) 22 25990557 Homo sapiens
GEX167499
Liver enzyme levels (alkaline phosphatase) Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (more detail) 22 22001757 Homo sapiens
WAG001236
links between pyk2 and map kinases This diagram is a compilation of Pyk2 effort cascades. In specific cell types the receptor and effo (more detail) 22 NA Homo sapiens
TAX027047
GO:0051537 molecular function 2 iron, 2 sulfur cluster binding Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster co (more detail) 22 NA Homo sapiens
TAX031011
GO:0098533 cellular component ATPase dependent transmembrane transport complex A transmembrane protein complex that functions in ATPase dependent active transport across a membran (more detail) 22 NA Homo sapiens
TAX019104
GO:0016578 biological process histone deubiquitination The modification of histones by removal of ubiquitin groups. (more detail) 22 NA Homo sapiens
IEI011408
Protein protein interactors of human gene RNF167 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF167 (SwissProt ID (more detail) 22 17535438 Homo sapiens
IEI004282
Protein protein interactors of human gene ERO1A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ERO1A (SwissProt ID= (more detail) 22 17535438 Homo sapiens
IEI009445
Protein protein interactors of human gene PAG1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PAG1 (SwissProt ID=Q (more detail) 20 17535438 Homo sapiens
TAX029192
GO:0070932 biological process histone H3 deacetylation The modification of histone H3 by the removal of one or more acetyl groups. (more detail) 20 NA Homo sapiens
TAX028946
GO:0070469 cellular component respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated wi (more detail) 20 NA Homo sapiens
IEI010190
Protein protein interactors of human gene POLB from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene POLB (SwissProt ID=P (more detail) 20 17535438 Homo sapiens
IEI014977
Protein protein interactors of human gene WDCP from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene WDCP (SwissProt ID=Q (more detail) 20 17535438 Homo sapiens
IEI008679
Protein protein interactors of human gene NDUFAF1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NDUFAF1 (SwissProt I (more detail) 20 17535438 Homo sapiens
TAX000910
Genes annotated by the GO term GO:0000118. Complex that possesses histone deacetylase activity. (more detail) 20 NA Homo sapiens
MOX000173
Genes associated with Computational Drug Signature 1,2,9,10 tetramethoxyaporphine Genes associated with Computational Drug Signature 1,2,9,10-tetramethoxyaporphine, curated by the Dr (more detail) 20 25990557 Homo sapiens
MOX000808
Genes associated with Computational Drug Signature cypermethrin Genes associated with Computational Drug Signature cypermethrin, curated by the Drug Signature Datab (more detail) 20 25990557 Homo sapiens
MAX000644
The lung adenocarcinoma TSP (tumor sequencing project) genes mutations in which show positive correlation with the higher overall mutation rate. Determining the genetic basis of cancer requires comprehensive analyses of large collections of hist (more detail) 20 NA Homo sapiens
MOX006184
Genes associated with Computational Drug Signature 5 Aminosalicylic acid Genes associated with Computational Drug Signature 5-Aminosalicylic acid, curated by the Drug Signat (more detail) 20 25990557 Homo sapiens
MOX003497
Genes associated with Computational Drug Signature Veliparib Genes associated with Computational Drug Signature Veliparib, curated by the Drug Signature Database (more detail) 18 25990557 Homo sapiens
WIG001364
Doxorubicin Pathway (Cancer Cell), Pharmacodynamics Representation of the candidate genes involved in the action of doxorubicin in a stylized cancer cel (more detail) 18 NA Homo sapiens
WIG001376
Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics Representation of candidate genes involved in the metabolism of lamivudine and its mechanism of anti (more detail) 18 NA Homo sapiens
TAX000539
Genes annotated by the GO term GO:0006493. The formation of O glycans by addition of glycosyl groups either to the hydroxyl group of peptidyl serine, peptidyl threonine, peptidyl hydroxylysine, or peptidyl hydroxyproline, or to the phenol group of peptidyl tyrosine. (more detail) 18 NA Homo sapiens
MOX015249
Genes associated with Computational Drug Signature suramin Genes associated with Computational Drug Signature suramin, curated by the Drug Signature Database ( (more detail) 18 25990557 Homo sapiens
MOX017028
Genes associated with Computational Drug Signature Guanidine hydrochloride Genes associated with Computational Drug Signature Guanidine hydrochloride, curated by the Drug Sign (more detail) 18 25990557 Homo sapiens
TAX015857
GO:0005665 cellular component RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a m (more detail) 18 NA Homo sapiens
TAX016145
GO:0006119 biological process oxidative phosphorylation The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operati (more detail) 18 NA Homo sapiens
TAX020794
GO:0031078 molecular function histone deacetylase activity (H3 K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine ( (more detail) 11 NA Homo sapiens
TAX025414
GO:0046051 biological process UTP metabolic process The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. (more detail) 11 NA Homo sapiens
TAX015041
GO:0004303 molecular function estradiol 17 beta dehydrogenase activity Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. (more detail) 11 NA Homo sapiens
TAX032169
GO:1901569 biological process fatty acid derivative catabolic process The chemical reactions and pathways resulting in the breakdown of fatty acid derivative. (more detail) 11 NA Homo sapiens
TAX015907
GO:0005753 cellular component mitochondrial proton transporting ATP synthase complex A proton-transporting ATP synthase complex found in the mitochondrial membrane. (more detail) 11 NA Homo sapiens
TAX028492
GO:0061578 molecular function Lys63 specific deubiquitinase activity Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. (more detail) 11 NA Homo sapiens
TAX029261
GO:0071027 biological process nuclear RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs within the nuc (more detail) 11 NA Homo sapiens
TAX016516
GO:0006670 biological process sphingosine metabolic process The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-o (more detail) 11 NA Homo sapiens
TAX031324
GO:0099133 biological process ATP hydrolysis coupled anion transmembrane transport The transport of an inorganic anion across a membrane and against an electrochemical gradient, using (more detail) 11 NA Homo sapiens
TAX019284
GO:0016888 molecular function endodeoxyribonuclease activity, producing 5' phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal bre (more detail) 11 NA Homo sapiens
TAX025400
GO:0046030 molecular function inositol trisphosphate phosphatase activity Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. (more detail) 11 NA Homo sapiens
TAX015390
GO:0004791 molecular function thioredoxin disulfide reductase activity Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide. (more detail) 11 NA Homo sapiens
TAX026503
GO:0050667 biological process homocysteine metabolic process The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercapt (more detail) 11 NA Homo sapiens
TAX021301
GO:0032041 molecular function NAD dependent histone deacetylase activity (H3 K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine ( (more detail) 11 NA Homo sapiens
TAX015008
GO:0004143 molecular function diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. (more detail) 11 NA Homo sapiens
TAX017216
GO:0008349 molecular function MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kin (more detail) 11 NA Homo sapiens
TAX030592
GO:0090656 biological process t circle formation A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t (more detail) 11 NA Homo sapiens
TAX017810
GO:0009931 molecular function calcium dependent protein serine/threonine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a pro (more detail) 11 NA Homo sapiens
TAX019803
GO:0019774 cellular component proteasome core complex, beta subunit complex The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. (more detail) 11 NA Homo sapiens
TAX024281
GO:0043295 molecular function glutathione binding Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amin (more detail) 11 NA Homo sapiens
TAX019234
GO:0016813 molecular function hydrolase activity, acting on carbon nitrogen (but not peptide) bonds, in linear amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound (more detail) 11 NA Homo sapiens
TAX026404
GO:0050072 molecular function m7G(5')pppN diphosphatase activity Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosi (more detail) 11 NA Homo sapiens
TAX025817
GO:0046933 molecular function proton transporting ATP synthase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: (more detail) 11 NA Homo sapiens
TAX014953
GO:0004065 molecular function arylsulfatase activity Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. (more detail) 11 NA Homo sapiens
TAX032422
GO:1902221 biological process erythrose 4 phosphate/phosphoenolpyruvate family amino acid metabolic process The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino (more detail) 11 NA Homo sapiens
TAX017347
GO:0008556 molecular function potassium transporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 11 NA Homo sapiens
TAX024446
GO:0043560 molecular function insulin receptor substrate binding Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins (more detail) 11 NA Homo sapiens
TAX025534
GO:0046349 biological process amino sugar biosynthetic process The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing (more detail) 11 NA Homo sapiens
TAX015049
GO:0004312 molecular function fatty acid synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n (more detail) 11 NA Homo sapiens
TAX016175
GO:0006183 biological process GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. (more detail) 11 NA Homo sapiens
TAX015294
GO:0004652 molecular function polynucleotide adenylyltransferase activity Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition o (more detail) 11 NA Homo sapiens
TAX016426
GO:0006559 biological process L phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpro (more detail) 11 NA Homo sapiens
TAX023196
GO:0035999 biological process tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydr (more detail) 11 NA Homo sapiens
TAX025037
GO:0045259 cellular component proton transporting ATP synthase complex A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP dur (more detail) 11 NA Homo sapiens
TAX019270
GO:0016868 molecular function intramolecular transferase activity, phosphotransferases Catalysis of the transfer of a phosphate group from one position to another within a single molecule (more detail) 11 NA Homo sapiens
TAX023907
GO:0042577 molecular function lipid phosphatase activity Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. (more detail) 11 NA Homo sapiens
TAX024888
GO:0045006 biological process DNA deamination The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosi (more detail) 11 NA Homo sapiens
TAX018897
GO:0016175 molecular function superoxide generating NADPH oxidase activity Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. (more detail) 11 NA Homo sapiens
TAX027431
GO:0052697 biological process xenobiotic glucuronidation The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant gluc (more detail) 11 NA Homo sapiens
TAX027443
GO:0052743 molecular function inositol tetrakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosp (more detail) 11 NA Homo sapiens
TAX015893
GO:0005736 cellular component RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a mu (more detail) 11 NA Homo sapiens
TAX014907
GO:0004000 molecular function adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3. (more detail) 11 NA Homo sapiens
TAX025827
GO:0046950 biological process cellular ketone body metabolic process The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoa (more detail) 11 NA Homo sapiens
TAX015108
GO:0004385 molecular function guanylate kinase activity Catalysis of the reaction: ATP + GMP = ADP + GDP. (more detail) 11 NA Homo sapiens
TAX016425
GO:0006558 biological process L phenylalanine metabolic process The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylp (more detail) 11 NA Homo sapiens
TAX017559
GO:0009162 biological process deoxyribonucleoside monophosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consis (more detail) 11 NA Homo sapiens
TAX017676
GO:0009396 biological process folic acid containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. (more detail) 11 NA Homo sapiens
TAX019699
GO:0019371 biological process cyclooxygenase pathway The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in (more detail) 11 NA Homo sapiens
TAX025410
GO:0046040 biological process IMP metabolic process The chemical reactions and pathways involving IMP, inosine monophosphate. (more detail) 11 NA Homo sapiens
TAX015253
GO:0004596 molecular function peptide alpha N acetyltransferase activity Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the (more detail) 11 NA Homo sapiens
TAX032423
GO:1902222 biological process erythrose 4 phosphate/phosphoenolpyruvate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolp (more detail) 11 NA Homo sapiens
TAX017549
GO:0009151 biological process purine deoxyribonucleotide metabolic process The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of d (more detail) 11 NA Homo sapiens
TAX024234
GO:0043225 molecular function ATPase coupled anion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 11 NA Homo sapiens
TAX016573
GO:0006751 biological process glutathione catabolic process The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutam (more detail) 11 NA Homo sapiens
MEX001820
Genes associated with Kinase Inhibitor CHEMBL1970317 Genes associated with Kinase Inhibitor CHEMBL1970317, curated by the Drug Signature Database (DSigDB (more detail) 11 25990557 Homo sapiens
MEX001836
Genes associated with Kinase Inhibitor CHEMBL456252 Genes associated with Kinase Inhibitor CHEMBL456252, curated by the Drug Signature Database (DSigDB) (more detail) 11 25990557 Homo sapiens
WIG001312
Genes involved in Unwinding of DNA (more detail) 11 NA Homo sapiens
TAX000802
Genes annotated by the GO term GO:0006100. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle. (more detail) 11 NA Homo sapiens
WIG000434
Activation of Src by Protein tyrosine phosphatase alpha Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a prote (more detail) 11 NA Homo sapiens
PEX001174
Aldo ket red: Aldo/keto reductase family This family includes a number of K+ ion channel beta chain regulatory domains - these are reported t (more detail) 11 NA Homo sapiens
MEX001639
Genes associated with Kinase Inhibitor Ruboxistaurin Genes associated with Kinase Inhibitor Ruboxistaurin, curated by the Drug Signature Database (DSigDB (more detail) 11 25990557 Homo sapiens
MEX001687
Genes associated with Kinase Inhibitor Saracatinib Genes associated with Kinase Inhibitor Saracatinib, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
TAX000444
Genes annotated by the GO term GO:0031365. The alteration of the N terminal amino acid residue in a protein. (more detail) 11 NA Homo sapiens
WIG001118
Genes involved in Pyrimidine catabolism (more detail) 11 NA Homo sapiens
GEX000537
cytogenetic studies cytogenetic studies associated genes. PAGER constructed this gene set by grouping all genes which ar (more detail) 11 NA Homo sapiens
TAX001108
Genes annotated by the GO term GO:0004180. Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C terminal end of a peptide or polypeptide. (more detail) 11 NA Homo sapiens
TAX001072
Genes annotated by the GO term GO:0004033. Catalysis of the NADPH dependent reduction of carbonyl compounds. (more detail) 11 NA Homo sapiens
PEX002663
PARP: Poly(ADP ribose) polymerase catalytic domain Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itsel (more detail) 11 NA Homo sapiens
TAX013598
GO:0001055 molecular function RNA polymerase II activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA (more detail) 11 NA Homo sapiens
MEX001255
Genes associated with Kinase Inhibitor Kinome 1199 Genes associated with Kinase Inhibitor Kinome_1199, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX001203
Genes associated with Kinase Inhibitor Cdk2 Inhibitor IV, NU6140 Genes associated with Kinase Inhibitor Cdk2 Inhibitor IV, NU6140, curated by the Drug Signature Data (more detail) 11 25990557 Homo sapiens
MOX009947
Genes associated with Computational Drug Signature CHEMBL380598 Genes associated with Computational Drug Signature CHEMBL380598, curated by the Drug Signature Datab (more detail) 11 25990557 Homo sapiens
WIG001194
Genes involved in Signaling by activated point mutants of FGFR1 (more detail) 11 NA Homo sapiens
TAX001114
Genes annotated by the GO term GO:0019829. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). (more detail) 11 NA Homo sapiens
TAX001084
Genes annotated by the GO term GO:0004065. Catalysis of the reaction: a phenol sulfate + H2O = a phenol + SO4(2 ) (sulfate). (more detail) 11 NA Homo sapiens
TAX000560
Genes annotated by the GO term GO:0000209. Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain. (more detail) 11 NA Homo sapiens
WIG001768
Lysine Degradation in Human Liver Lysine Degradation in Human Liver (more detail) 11 NA Homo sapiens
MEX001927
Genes associated with Kinase Inhibitor Kinome 528 Genes associated with Kinase Inhibitor Kinome_528, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MOX003439
Genes associated with Computational Drug Signature trans 1,2 Dihydro 1,2 naphthalenediol Genes associated with Computational Drug Signature trans-1,2-Dihydro-1,2-naphthalenediol, curated by (more detail) 11 25990557 Homo sapiens
FOX000544
Genes in the cancer module 211 (more detail) 11 NA Homo sapiens
MOX012697
Genes associated with Computational Drug Signature flavin adenine dinucleotide Genes associated with Computational Drug Signature flavin adenine dinucleotide, curated by the Drug (more detail) 11 25990557 Homo sapiens
WAG001626
C21 Steroid hormone metabolism Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrate (more detail) 11 NA Homo sapiens
MOX012940
Genes associated with Computational Drug Signature GSK690693 Genes associated with Computational Drug Signature GSK690693, curated by the Drug Signature Database (more detail) 11 25990557 Homo sapiens
WIG001356
Imatinib Pathway, Pharmacokinetics/Pharmacodynamics Imatinib Pathway, Pharmacokinetics/Pharmacodynamics (more detail) 11 NA Homo sapiens
MEX001269
Genes associated with Kinase Inhibitor A 443654 Genes associated with Kinase Inhibitor A-443654, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX001348
Genes associated with Kinase Inhibitor GW589933X Genes associated with Kinase Inhibitor GW589933X, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX002305
Genes associated with Kinase Inhibitor Kinome 248 Genes associated with Kinase Inhibitor Kinome_248, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX001817
Genes associated with Kinase Inhibitor alsterpaullone Genes associated with Kinase Inhibitor alsterpaullone, curated by the Drug Signature Database (DSigD (more detail) 11 25990557 Homo sapiens
MOX003154
Genes associated with Computational Drug Signature Tipifarnib Genes associated with Computational Drug Signature Tipifarnib, curated by the Drug Signature Databas (more detail) 11 25990557 Homo sapiens
WIG001203
Genes involved in Signaling by FGFR3 mutants (more detail) 11 NA Homo sapiens
WAG001010
roles of beta arrestin dependent recruitment of src kinases in gpcr signaling The binding of ?arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyr (more detail) 11 NA Homo sapiens
TAX001135
Genes annotated by the GO term GO:0019213. Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. (more detail) 11 NA Homo sapiens
MEX001674
Genes associated with Kinase Inhibitor InSolution¿¿KT5720 Genes associated with Kinase Inhibitor InSolution¿¿KT5720, curated by the Drug Signa (more detail) 11 25990557 Homo sapiens
TAX013656
GO:0001325 biological process formation of extrachromosomal circular DNA Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not (more detail) 11 NA Homo sapiens
MOX001119
Genes associated with Computational Drug Signature 15(S) HETE d8 Genes associated with Computational Drug Signature 15(S)-HETE-d8, curated by the Drug Signature Data (more detail) 11 25990557 Homo sapiens
FOX000681
Genes in the cancer module 377 (more detail) 11 NA Homo sapiens
WAG000408
Geraniol degradation (more detail) 11 NA Homo sapiens
TAX001091
Genes annotated by the GO term GO:0004003. Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. (more detail) 11 NA Homo sapiens
WIG001360
Benzodiazepine Pathway, Pharmacokinetics Benzodiazepine Pathway, Pharmacokinetics (more detail) 11 NA Homo sapiens
MEX001244
Genes associated with Kinase Inhibitor 761437 28 9 Genes associated with Kinase Inhibitor 761437-28-9, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX000232
Genes associated with Approved Drug nevirapine Genes associated with Approved Drug nevirapine, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX001625
Genes associated with Kinase Inhibitor PDK1/Akt/Flt Dual Pathway Inhibitor Genes associated with Kinase Inhibitor PDK1/Akt/Flt Dual Pathway Inhibitor, curated by the Drug Sign (more detail) 11 25990557 Homo sapiens
TAX001151
Genes annotated by the GO term GO:0016893. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5' phosphomonoesters. (more detail) 11 NA Homo sapiens
WIG000737
Genes involved in CD28 dependent Vav1 pathway (more detail) 11 NA Homo sapiens
MEX002211
Genes associated with Kinase Inhibitor Kinome 812 Genes associated with Kinase Inhibitor Kinome_812, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX002233
Genes associated with Kinase Inhibitor CHEMBL1969102 Genes associated with Kinase Inhibitor CHEMBL1969102, curated by the Drug Signature Database (DSigDB (more detail) 11 25990557 Homo sapiens
WIG000999
Genes involved in mRNA Decay by 3' to 5' Exoribonuclease (more detail) 11 NA Homo sapiens
MOX014978
Genes associated with Computational Drug Signature Saracatinib Genes associated with Computational Drug Signature Saracatinib, curated by the Drug Signature Databa (more detail) 11 25990557 Homo sapiens
WAG001211
Benzoate degradation via CoA ligation (more detail) 11 NA Homo sapiens
WIG001054
Genes involved in p38MAPK events (more detail) 13 NA Homo sapiens
MOX014917
Genes associated with Computational Drug Signature RUTIN Genes associated with Computational Drug Signature RUTIN, curated by the Drug Signature Database (DS (more detail) 13 25990557 Homo sapiens
MEX000071
Genes associated with Approved Drug chlorthalidone Genes associated with Approved Drug chlorthalidone, curated by the Drug Signature Database (DSigDB). (more detail) 13 25990557 Homo sapiens
MOX003003
Genes associated with Computational Drug Signature Fraxetin Genes associated with Computational Drug Signature Fraxetin, curated by the Drug Signature Database (more detail) 13 25990557 Homo sapiens
WIG001927
Irinotecan Pathway Irinotecan Pathway (more detail) 13 NA Homo sapiens
TAX000730
Genes annotated by the GO term GO:0009259. The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5' hydroxyl group of its glycose moiety. (more detail) 13 NA Homo sapiens
WIG001403
Irinotecan Pathway, Pharmacokinetics Model human liver cell showing blood, bile and intestinal compartments, indicating tissue specific i (more detail) 13 NA Homo sapiens
TAX013294
GO:0000177 cellular component cytoplasmic exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity pr (more detail) 13 NA Homo sapiens
WIG000931
Genes involved in Initial triggering of complement (more detail) 13 NA Homo sapiens
MOX003926
Genes associated with Computational Drug Signature N,N Diethyl 3 methylbenzamide Genes associated with Computational Drug Signature N,N-Diethyl-3-methylbenzamide, curated by the Dru (more detail) 13 25990557 Homo sapiens
PEX001641
Thioredoxin: Thioredoxin Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of (more detail) 13 NA Homo sapiens
TAX031318
GO:0099116 biological process tRNA 5' end processing The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA. (more detail) 13 NA Homo sapiens
TAX016385
GO:0006516 biological process glycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that co (more detail) 13 NA Homo sapiens
TAX017640
GO:0009263 biological process deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound (more detail) 13 NA Homo sapiens
TAX021890
GO:0032958 biological process inositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6 (more detail) 13 NA Homo sapiens
IEI008390
Protein protein interactors of human gene MUS81 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MUS81 (SwissProt ID= (more detail) 13 17535438 Homo sapiens
TAX025030
GO:0045239 cellular component tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. (more detail) 13 NA Homo sapiens
TAX016543
GO:0006703 biological process estrogen biosynthetic process The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones th (more detail) 13 NA Homo sapiens
TAX026083
GO:0048188 cellular component Set1C/COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex c (more detail) 13 NA Homo sapiens
WIG001167
Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter (more detail) 23 NA Homo sapiens
WIG000416
Rac 1 cell motility signaling pathway Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellul (more detail) 23 NA Homo sapiens
WIG000277
Caspase Cascade in Apoptosis Apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface recep (more detail) 23 NA Homo sapiens
WIG000602
Proximal tubule bicarbonate reclamation One of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, t (more detail) 23 NA Homo sapiens
FOX000526
Genes in the cancer module 196 (more detail) 23 NA Homo sapiens
MOX004329
Genes associated with Computational Drug Signature L methionine Genes associated with Computational Drug Signature L-methionine, curated by the Drug Signature Datab (more detail) 23 25990557 Homo sapiens
WIG000147
Signaling events mediated by PRL (more detail) 23 NA Homo sapiens
WIG000220
G alpha 12 Pathway na (more detail) 23 NA Homo sapiens
TAX016589
GO:0006779 biological process porphyrin containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of der (more detail) 23 NA Homo sapiens
IEI002242
Protein protein interactors of human gene CDK13 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CDK13 (SwissProt ID= (more detail) 23 17535438 Homo sapiens
MAX001955
Genes involved in glycogen metabolism; based on literature and sequence annotation resources and converted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 21 NA Homo sapiens
WIG000777
Genes involved in CTLA4 inhibitory signaling (more detail) 21 NA Homo sapiens
FOX000579
Genes in the cancer module 253 (more detail) 21 NA Homo sapiens
MOX012798
Genes associated with Computational Drug Signature Gallic acid Genes associated with Computational Drug Signature Gallic acid, curated by the Drug Signature Databa (more detail) 21 25990557 Homo sapiens
WIG000163
Sphingosine 1 phosphate (S1P) pathway (more detail) 21 NA Homo sapiens
FEX003495
Viral Cairo08 52genes Table S6b. Overrepresented GO Terms among Genes Differently Expressed between HBs and Nontumor Liver (more detail) 21 19061838 Homo sapiens
MOX000619
Genes associated with Computational Drug Signature Dihydrocapsaicin Genes associated with Computational Drug Signature Dihydrocapsaicin, curated by the Drug Signature D (more detail) 21 25990557 Homo sapiens
WAG000204
Mismatch repair D mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintainin (more detail) 21 NA Homo sapiens
WIG001153
Genes involved in Regulatory RNA pathways (more detail) 21 NA Homo sapiens
IEI014575
Protein protein interactors of human gene UBE2G1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2G1 (SwissProt ID (more detail) 21 17535438 Homo sapiens
TAX019088
GO:0016556 biological process mRNA modification The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecu (more detail) 21 NA Homo sapiens
MOX015668
Genes associated with Computational Drug Signature Tyrphostin 25 Genes associated with Computational Drug Signature Tyrphostin 25, curated by the Drug Signature Data (more detail) 15 25990557 Homo sapiens
FEX001587
Leukemia Sanchez Guijo08 15genes SuppTable2m Genes related to the ubiquitination process (more detail) 15 18722011 Homo sapiens
MAX000512
Proteins that regulate activity of PRKDC [GeneID=5591] . Double-strand breaks (DSBs) arise endogenously during normal cellular processes and exogenously by g (more detail) 15 NA Homo sapiens
MOX012062
Genes associated with Computational Drug Signature coumarin Genes associated with Computational Drug Signature coumarin, curated by the Drug Signature Database (more detail) 15 25990557 Homo sapiens
WIG001407
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics Etoposide cellular disposition and effects. (more detail) 15 NA Homo sapiens
WIG001225
Genes involved in Signalling to p38 via RIT and RIN (more detail) 15 NA Homo sapiens
TAX000017
Genes annotated by the GO term GO:0009060. The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. (more detail) 15 NA Homo sapiens
WIG000114
LPA4 mediated signaling events (more detail) 15 NA Homo sapiens
WIG000184
PAR4 mediated thrombin signaling events (more detail) 15 NA Homo sapiens
MOX005809
Genes associated with Computational Drug Signature 3,5 dinitrocatechol Genes associated with Computational Drug Signature 3,5-dinitrocatechol, curated by the Drug Signatur (more detail) 15 25990557 Homo sapiens
TAX001306
Genes annotated by the GO term GO:0004629. Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2 diacylglycerol + choline phosphate. (more detail) 15 NA Homo sapiens
TAX000239
Genes annotated by the GO term GO:0006664. The chemical reactions and pathways involving glycolipids, compounds containing (usually) 1 4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. (more detail) 15 NA Homo sapiens
WAG001459
aspirin blocks signaling pathway involved in platelet activation Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotti (more detail) 15 NA Homo sapiens
WIG000779
Genes involved in Cyclin A/B1 associated events during G2/M transition (more detail) 15 NA Homo sapiens
FOX000788
Genes in the cancer module 530 (more detail) 15 NA Homo sapiens
MEX000095
Genes associated with Approved Drug diclofenac Genes associated with Approved Drug diclofenac, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
MOX013566
Genes associated with Computational Drug Signature Mangostin Genes associated with Computational Drug Signature Mangostin, curated by the Drug Signature Database (more detail) 15 25990557 Homo sapiens
WIG001365
Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics Representation of the candidate genes involved in adverse effects of doxorubicin in a stylized cardi (more detail) 15 NA Homo sapiens
MEX000755
Genes associated with Approved Drug valdecoxib Genes associated with Approved Drug valdecoxib, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
TAX029270
GO:0071044 biological process histone mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). (more detail) 15 NA Homo sapiens
TAX022432
GO:0034356 biological process NAD biosynthesis via nicotinamide riboside salvage pathway The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (more detail) 15 NA Homo sapiens
IEI011248
Protein protein interactors of human gene RGS16 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RGS16 (SwissProt ID= (more detail) 15 17535438 Homo sapiens
IEI003380
Protein protein interactors of human gene DCUN1D5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DCUN1D5 (SwissProt I (more detail) 15 17535438 Homo sapiens
TAX024494
GO:0043650 biological process dicarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic ac (more detail) 15 NA Homo sapiens
TAX020991
GO:0031434 molecular function mitogen activated protein kinase kinase binding Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any prote (more detail) 15 NA Homo sapiens
WAG001130
RNA Polymerase I Chain Elongation (more detail) 19 NA Homo sapiens
MOX015673
Genes associated with Computational Drug Signature U 0126 Genes associated with Computational Drug Signature U 0126, curated by the Drug Signature Database (D (more detail) 19 25990557 Homo sapiens
WAG000724
RNA Polymerase I Transcription (more detail) 19 NA Homo sapiens
MOX016511
Genes associated with Computational Drug Signature CEFIXIME Genes associated with Computational Drug Signature CEFIXIME, curated by the Drug Signature Database (more detail) 19 25990557 Homo sapiens
TAX016253
GO:0006312 biological process mitotic recombination The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homolo (more detail) 19 NA Homo sapiens
TAX033408
GO:1904355 biological process positive regulation of telomere capping Any process that activates or increases the frequency, rate or extent of telomere capping. (more detail) 17 NA Homo sapiens
IEI003883
Protein protein interactors of human gene DYRK4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DYRK4 (SwissProt ID= (more detail) 17 17535438 Homo sapiens
IEI007898
Protein protein interactors of human gene METAP2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene METAP2 (SwissProt ID (more detail) 17 17535438 Homo sapiens
IEI010232
Protein protein interactors of human gene POLR3B from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene POLR3B (SwissProt ID (more detail) 17 17535438 Homo sapiens
TAX026454
GO:0050435 biological process amyloid beta metabolic process The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer (more detail) 17 NA Homo sapiens
TAX001023
Genes annotated by the GO term GO:0045271. Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. (more detail) 17 NA Homo sapiens
TAX000973
Genes annotated by the GO term GO:0030964. An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyses the transfer of a pair of electrons from NADH to a quinone. (more detail) 17 NA Homo sapiens
TAX000967
Genes annotated by the GO term GO:0005747. A part of the respiratory chain located in the mitochondrion. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron sulfur clusters containing non heme iron. The iron undergoes oxidation reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. (more detail) 17 NA Homo sapiens
WIG000879
Genes involved in Glycogen breakdown (glycogenolysis) (more detail) 17 NA Homo sapiens
MOX003478
Genes associated with Computational Drug Signature NVP TAE684 Genes associated with Computational Drug Signature NVP-TAE684, curated by the Drug Signature Databas (more detail) 17 25990557 Homo sapiens
MOX002364
Genes associated with Computational Drug Signature o6 benzylguanine Genes associated with Computational Drug Signature o6-benzylguanine, curated by the Drug Signature D (more detail) 17 25990557 Homo sapiens
MEX000211
Genes associated with Approved Drug methazolamide Genes associated with Approved Drug methazolamide, curated by the Drug Signature Database (DSigDB). (more detail) 17 25990557 Homo sapiens
MOX002790
Genes associated with Computational Drug Signature bisindolylmaleimide iv Genes associated with Computational Drug Signature bisindolylmaleimide iv, curated by the Drug Signa (more detail) 17 25990557 Homo sapiens
WIG000204
PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. na (more detail) 17 NA Homo sapiens
WIG001201
Genes involved in Signaling by FGFR1 fusion mutants (more detail) 17 NA Homo sapiens
MOX014722
Genes associated with Computational Drug Signature quinalizarin Genes associated with Computational Drug Signature quinalizarin, curated by the Drug Signature Datab (more detail) 17 25990557 Homo sapiens
GEX000094
anemia, sickle cell anemia, sickle cell associated genes. PAGER constructed this gene set by grouping all genes which ar (more detail) 17 NA Homo sapiens
TAX000267
Genes annotated by the GO term GO:0006690. The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. (more detail) 17 NA Homo sapiens
MOX007059
Genes associated with Computational Drug Signature Arachidonic Acid (d8) Genes associated with Computational Drug Signature Arachidonic Acid (d8), curated by the Drug Signat (more detail) 17 25990557 Homo sapiens
GEX000778
head and neck cancer head and neck cancer associated genes. PAGER constructed this gene set by grouping all genes which a (more detail) 17 NA Homo sapiens
TAX013394
GO:0000400 molecular function four way junction DNA binding Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Hol (more detail) 17 NA Homo sapiens
MOX014380
Genes associated with Computational Drug Signature PD 173074 Genes associated with Computational Drug Signature PD 173074, curated by the Drug Signature Database (more detail) 17 25990557 Homo sapiens
TAX000822
Genes annotated by the GO term GO:0006766. The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water soluble or fat soluble and usually serve as components of coenzyme systems. (more detail) 17 NA Homo sapiens
WIG000796
Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) (more detail) 17 NA Homo sapiens
TAX017487
GO:0009071 biological process serine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, (more detail) 10 NA Homo sapiens
TAX016437
GO:0006570 biological process tyrosine metabolic process The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxy (more detail) 10 NA Homo sapiens
TAX017568
GO:0009173 biological process pyrimidine ribonucleoside monophosphate metabolic process The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound co (more detail) 10 NA Homo sapiens
TAX017823
GO:0009972 biological process cytidine deamination The removal of amino group in the presence of water. (more detail) 10 NA Homo sapiens
TAX025120
GO:0045504 molecular function dynein heavy chain binding Interacting selectively and non-covalently with a heavy chain of the dynein complex. (more detail) 10 NA Homo sapiens
TAX019161
GO:0016679 molecular function oxidoreductase activity, acting on diphenols and related substances as donors Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts a (more detail) 10 NA Homo sapiens
TAX025413
GO:0046049 biological process UMP metabolic process The chemical reactions and pathways involving UMP, uridine monophosphate. (more detail) 10 NA Homo sapiens
TAX020619
GO:0030681 cellular component multimeric ribonuclease P complex A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules (more detail) 10 NA Homo sapiens
TAX015237
GO:0004576 molecular function oligosaccharyl transferase activity Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbo (more detail) 10 NA Homo sapiens
TAX017386
GO:0008641 molecular function ubiquitin like modifier activating enzyme activity Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through (more detail) 10 NA Homo sapiens
TAX022776
GO:0035247 biological process peptidyl arginine omega N methylation The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue (more detail) 10 NA Homo sapiens
TAX017292
GO:0008474 molecular function palmitoyl (protein) hydrolase activity Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. (more detail) 10 NA Homo sapiens
TAX022551
GO:0034596 molecular function phosphatidylinositol phosphate 4 phosphatase activity Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. (more detail) 10 NA Homo sapiens
TAX031043
GO:0098599 molecular function palmitoyl hydrolase activity Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate. (more detail) 10 NA Homo sapiens
TAX019038
GO:0016461 cellular component unconventional myosin complex A portmanteau term for myosins other than myosin II. (more detail) 10 NA Homo sapiens
TAX023713
GO:0042178 biological process xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound (more detail) 10 NA Homo sapiens
TAX025921
GO:0047372 molecular function acylglycerol lipase activity Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. (more detail) 10 NA Homo sapiens
TAX025608
GO:0046501 biological process protoporphyrinogen IX metabolic process The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the (more detail) 10 NA Homo sapiens
TAX023130
GO:0035871 biological process protein K11 linked deubiquitination A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquiti (more detail) 10 NA Homo sapiens
TAX024001
GO:0042758 biological process long chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty ac (more detail) 10 NA Homo sapiens
TAX018787
GO:0015924 molecular function mannosyl oligosaccharide mannosidase activity Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharid (more detail) 10 NA Homo sapiens
TAX019179
GO:0016723 molecular function oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or (more detail) 10 NA Homo sapiens
TAX027223
GO:0051864 molecular function histone demethylase activity (H3 K36 specific) Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = (more detail) 10 NA Homo sapiens
TAX019630
GO:0019203 molecular function carbohydrate phosphatase activity Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. (more detail) 10 NA Homo sapiens
TAX026434
GO:0050308 molecular function sugar phosphatase activity Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. (more detail) 10 NA Homo sapiens
TAX023838
GO:0042436 biological process indole containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole ( (more detail) 10 NA Homo sapiens
TAX021250
GO:0031957 molecular function very long chain fatty acid CoA ligase activity Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-Co (more detail) 10 NA Homo sapiens
TAX018798
GO:0015937 biological process coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5 (more detail) 10 NA Homo sapiens
TAX025932
GO:0047429 molecular function nucleoside triphosphate diphosphatase activity Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. (more detail) 10 NA Homo sapiens
TAX031702
GO:0140078 molecular function class I DNA (apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving a (more detail) 10 NA Homo sapiens
TAX016436
GO:0006569 biological process tryptophan catabolic process The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid (more detail) 10 NA Homo sapiens
TAX016200
GO:0006228 biological process UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. (more detail) 10 NA Homo sapiens
TAX031099
GO:0098734 biological process macromolecule depalmitoylation The removal of palymitoyl groups from a macromolecule. (more detail) 10 NA Homo sapiens
TAX028786
GO:0070189 biological process kynurenine metabolic process The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine. (more detail) 10 NA Homo sapiens
IEI008506
Protein protein interactors of human gene MYT1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MYT1 (SwissProt ID=Q (more detail) 10 17535438 Homo sapiens
TAX019449
GO:0018026 biological process peptidyl lysine monomethylation The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. (more detail) 10 NA Homo sapiens
TAX018960
GO:0016290 molecular function palmitoyl CoA hydrolase activity Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. (more detail) 10 NA Homo sapiens
TAX025496
GO:0046218 biological process indolalkylamine catabolic process The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole (more detail) 10 NA Homo sapiens
TAX016178
GO:0006188 biological process IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. (more detail) 10 NA Homo sapiens
TAX022020
GO:0033179 cellular component proton transporting V type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transpo (more detail) 10 NA Homo sapiens
TAX016414
GO:0006547 biological process histidine metabolic process The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. (more detail) 10 NA Homo sapiens
TAX016230
GO:0006285 biological process base excision repair, AP site formation The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recog (more detail) 10 NA Homo sapiens
TAX017184
GO:0008296 molecular function 3' 5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. (more detail) 10 NA Homo sapiens
TAX019288
GO:0016892 molecular function endoribonuclease activity, producing 3' phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks t (more detail) 10 NA Homo sapiens
TAX025763
GO:0046838 biological process phosphorylated carbohydrate dephosphorylation The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound b (more detail) 10 NA Homo sapiens
WEX000075
Nucleotide Synthesis The genes related to nucleotide synthesis (metabolism) in tumor, immune, stroma using next-generatio (more detail) 10 NA Homo sapiens
TAX025403
GO:0046033 biological process AMP metabolic process The chemical reactions and pathways involving AMP, adenosine monophosphate. (more detail) 10 NA Homo sapiens
TAX025440
GO:0046087 biological process cytidine metabolic process The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucl (more detail) 10 NA Homo sapiens
TAX025489
GO:0046185 biological process aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound wi (more detail) 10 NA Homo sapiens
TAX015203
GO:0004526 molecular function ribonuclease P activity Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. (more detail) 10 NA Homo sapiens
TAX032000
GO:1901072 biological process glucosamine containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds ( (more detail) 10 NA Homo sapiens
TAX016193
GO:0006216 biological process cytidine catabolic process The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a wid (more detail) 10 NA Homo sapiens
TAX028990
GO:0070544 biological process histone H3 K36 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the hi (more detail) 10 NA Homo sapiens
TAX019262
GO:0016857 molecular function racemase and epimerase activity, acting on carbohydrates and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrat (more detail) 10 NA Homo sapiens
TAX019282
GO:0016886 molecular function ligase activity, forming phosphoric ester bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric (more detail) 10 NA Homo sapiens
TAX020835
GO:0031126 biological process snoRNA 3' end processing Any process involved in forming the mature 3' end of a snoRNA molecule. (more detail) 10 NA Homo sapiens
TAX015746
GO:0005391 molecular function sodium:potassium exchanging ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 10 NA Homo sapiens
TAX016197
GO:0006222 biological process UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. (more detail) 10 NA Homo sapiens
TAX017569
GO:0009174 biological process pyrimidine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophos (more detail) 10 NA Homo sapiens
TAX030778
GO:0097267 biological process omega hydroxylase P450 pathway The chemical reactions and pathways by which arachidonic acid is converted to other compounds initia (more detail) 10 NA Homo sapiens
TAX028951
GO:0070475 biological process rRNA base methylation The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in (more detail) 10 NA Homo sapiens
TAX017526
GO:0009128 biological process purine nucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a (more detail) 10 NA Homo sapiens
TAX019280
GO:0016884 molecular function carbon nitrogen ligase activity, with glutamine as amido N donor Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases cat (more detail) 10 NA Homo sapiens
TAX025575
GO:0046459 biological process short chain fatty acid metabolic process The chemical reactions and pathways involving fatty acids with a chain length of less than C6. (more detail) 10 NA Homo sapiens
TAX022481
GO:0034427 biological process nuclear transcribed mRNA catabolic process, exonucleolytic, 3' 5' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occu (more detail) 10 NA Homo sapiens
MEX001679
Genes associated with Kinase Inhibitor Kinome 504 Genes associated with Kinase Inhibitor Kinome_504, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX000193
Genes associated with Approved Drug mafenide Genes associated with Approved Drug mafenide, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MOX002210
Genes associated with Computational Drug Signature Hypaconitine Genes associated with Computational Drug Signature Hypaconitine, curated by the Drug Signature Datab (more detail) 10 25990557 Homo sapiens
TAX001377
Genes annotated by the GO term GO:0008373. Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors. (more detail) 10 NA Homo sapiens
MEX001919
Genes associated with Kinase Inhibitor BMS 345541 free base Genes associated with Kinase Inhibitor BMS-345541 free base, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MEX002334
Genes associated with Kinase Inhibitor Nilotinib Genes associated with Kinase Inhibitor Nilotinib, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX001700
Genes associated with Kinase Inhibitor PD 173074 Genes associated with Kinase Inhibitor PD 173074, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
WIG000829
Genes involved in Ethanol oxidation (more detail) 10 NA Homo sapiens
WIG001114
Genes involved in Purine catabolism (more detail) 10 NA Homo sapiens
TAX001188
Genes annotated by the GO term GO:0042054. Catalysis of the transfer of a methyl group (CH3 ) to a histone. (more detail) 10 NA Homo sapiens
MOX017941
Genes associated with Computational Drug Signature Afatinib Genes associated with Computational Drug Signature Afatinib, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MOX008993
Genes associated with Computational Drug Signature CHEMBL230686 Genes associated with Computational Drug Signature CHEMBL230686, curated by the Drug Signature Datab (more detail) 10 25990557 Homo sapiens
WIG000679
Genes involved in Adenylate cyclase activating pathway (more detail) 10 NA Homo sapiens
WAG001149
Unwinding of DNA (more detail) 10 NA Homo sapiens
FOX000542
Genes in the cancer module 21 (more detail) 10 NA Homo sapiens
TAX000534
Genes annotated by the GO term GO:0006471. The transfer, from NAD, of ADP ribose to protein amino acids. (more detail) 10 NA Homo sapiens
WIG000627
Taurine and hypotaurine metabolism (more detail) 10 NA Homo sapiens
PEX001303
Cyclin N: Cyclin, N terminal domain Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is r (more detail) 10 NA Homo sapiens
MOX014386
Genes associated with Computational Drug Signature PD 0183812 Genes associated with Computational Drug Signature PD-0183812, curated by the Drug Signature Databas (more detail) 10 25990557 Homo sapiens
WAG000695
Nicotinate metabolism (more detail) 10 NA Homo sapiens
MOX002418
Genes associated with Computational Drug Signature 8 Oxo dG Genes associated with Computational Drug Signature 8-Oxo-dG, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MOX005477
Genes associated with Computational Drug Signature 10Z Hymenialdisine Genes associated with Computational Drug Signature 10Z-Hymenialdisine, curated by the Drug Signature (more detail) 10 25990557 Homo sapiens
MEX001737
Genes associated with Kinase Inhibitor GW612286X Genes associated with Kinase Inhibitor GW612286X, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX001743
Genes associated with Kinase Inhibitor CHEMBL1956068 Genes associated with Kinase Inhibitor CHEMBL1956068, curated by the Drug Signature Database (DSigDB (more detail) 10 25990557 Homo sapiens
MEX002075
Genes associated with Kinase Inhibitor 1 [4 (4 aminothieno[2,3 d]pyrimidin 5 yl)phenyl] 3 (3 methylphenyl)urea Genes associated with Kinase Inhibitor 1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylp (more detail) 10 25990557 Homo sapiens
WIG000335
Glycolysis Pathway Glycolysis was one of the first metabolic pathways studied and is one of the best understood, in ter (more detail) 10 NA Homo sapiens
TAX001324
Genes annotated by the GO term GO:0033558. Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. (more detail) 10 NA Homo sapiens
WIG000518
Folate biosynthesis (more detail) 10 NA Homo sapiens
TAX001149
Genes annotated by the GO term GO:0004520. Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. (more detail) 10 NA Homo sapiens
WIG001251
Genes involved in Synthesis of PE (more detail) 10 NA Homo sapiens
TAX001284
Genes annotated by the GO term GO:0016667. Catalysis of an oxidation reduction (redox) reaction in which a sulfur containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. (more detail) 10 NA Homo sapiens
PEX002031
Metallophos: Calcineurin like phosphoesterase This family includes a diverse range of phosphoesterases 1, including protein phosphoserine phosphat (more detail) 10 NA Homo sapiens
MOX012431
Genes associated with Computational Drug Signature doxorubicin Genes associated with Computational Drug Signature doxorubicin, curated by the Drug Signature Databa (more detail) 10 25990557 Homo sapiens
WAG000812
1 and 2 Methylnaphthalene degradation (more detail) 10 NA Homo sapiens
WAG001135
Synthesis of bile acids and bile salts (more detail) 10 NA Homo sapiens
MEX001588
Genes associated with Kinase Inhibitor AG F 35231 Genes associated with Kinase Inhibitor AG-F-35231, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
TAX001187
Genes annotated by the GO term GO:0042826. Interacting selectively with the enzyme histone deacetylase. (more detail) 10 NA Homo sapiens
WIG001245
Genes involved in Synthesis of bile acids and bile salts via 24 hydroxycholesterol (more detail) 10 NA Homo sapiens
TAX001291
Genes annotated by the GO term GO:0016706. Catalysis of an oxidation reduction (redox) reaction in which hydrogen or electrons are transferred from 2 oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. (more detail) 10 NA Homo sapiens
MOX014383
Genes associated with Computational Drug Signature PD 0173956 Genes associated with Computational Drug Signature PD-0173956, curated by the Drug Signature Databas (more detail) 10 25990557 Homo sapiens
WAG001245
role of beta arrestins in the activation and targeting of map kinases The binding of ?arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kise activation c (more detail) 10 NA Homo sapiens
TAX001163
Genes annotated by the GO term GO:0008417. Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. (more detail) 10 NA Homo sapiens
MOX003384
Genes associated with Computational Drug Signature monohydroxymethoxychlor Genes associated with Computational Drug Signature monohydroxymethoxychlor, curated by the Drug Sign (more detail) 10 25990557 Homo sapiens
MOX012803
Genes associated with Computational Drug Signature gamma Imino ATP Genes associated with Computational Drug Signature gamma-Imino-ATP, curated by the Drug Signature Da (more detail) 10 25990557 Homo sapiens
MEX001222
Genes associated with Kinase Inhibitor GSK 3 Inhibitor XIII Genes associated with Kinase Inhibitor GSK-3 Inhibitor XIII, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MEX000910
Genes associated with Approved Drug telaprevir Genes associated with Approved Drug telaprevir, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX000658
Genes associated with Approved Drug sildenafil citrate Genes associated with Approved Drug sildenafil citrate, curated by the Drug Signature Database (DSig (more detail) 10 25990557 Homo sapiens
TAX001239
Genes annotated by the GO term GO:0000030. Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. (more detail) 10 NA Homo sapiens
FOX000751
Genes in the cancer module 471 (more detail) 10 NA Homo sapiens
FOX000778
Genes in the cancer module 514 (more detail) 10 NA Homo sapiens
TAX001288
Genes annotated by the GO term GO:0016645. Catalysis of an oxidation reduction (redox) reaction in which a CH NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. (more detail) 10 NA Homo sapiens
MOX014394
Genes associated with Computational Drug Signature PD166326 Genes associated with Computational Drug Signature PD166326, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MEX001900
Genes associated with Kinase Inhibitor BMS 345541 free base Genes associated with Kinase Inhibitor BMS-345541 free base, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
MEX001630
Genes associated with Kinase Inhibitor Kinome 2812 Genes associated with Kinase Inhibitor Kinome_2812, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX001641
Genes associated with Kinase Inhibitor 1 [4 (4 Aminothieno[2,3 D]pyrimidin 5 Yl)phenyl] 3 [2 Fluoro 5 (Trifluoromethyl)phenyl]urea Genes associated with Kinase Inhibitor 1-[4-(4-Aminothieno[2,3-D]pyrimidin-5-Yl)phenyl]-3-[2-Fluoro- (more detail) 10 25990557 Homo sapiens
FOX000430
Genes in the cancer module 101 (more detail) 10 NA Homo sapiens
WAG000923
Synthesis of bile acids and bile salts via 24 hydroxycholesterol (more detail) 10 NA Homo sapiens
TAX000139
Genes annotated by the GO term GO:0051187. The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. (more detail) 10 NA Homo sapiens
PEX002589
Aldedh: Aldehyde dehydrogenase family This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family (more detail) 10 NA Homo sapiens
MEX001313
Genes associated with Kinase Inhibitor GSK2220400A Genes associated with Kinase Inhibitor GSK2220400A, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX002245
Genes associated with Kinase Inhibitor Kinome 192 Genes associated with Kinase Inhibitor Kinome_192, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX002390
Genes associated with Kinase Inhibitor CHEMBL212299 Genes associated with Kinase Inhibitor CHEMBL212299, curated by the Drug Signature Database (DSigDB) (more detail) 10 25990557 Homo sapiens
MEX002168
Genes associated with Kinase Inhibitor GW782612X Genes associated with Kinase Inhibitor GW782612X, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX002193
Genes associated with Kinase Inhibitor Kinome 1218 Genes associated with Kinase Inhibitor Kinome_1218, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
TAX000136
Genes annotated by the GO term GO:0009108. The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. (more detail) 10 NA Homo sapiens
TAX021302
GO:0032042 biological process mitochondrial DNA metabolic process The chemical reactions and pathways involving mitochondrial DNA. (more detail) 12 NA Homo sapiens
TAX023988
GO:0042738 biological process exogenous drug catabolic process The chemical reactions and pathways resulting in the breakdown of a drug that has originated externa (more detail) 12 NA Homo sapiens
TAX020748
GO:0030983 molecular function mismatched DNA binding Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatche (more detail) 12 NA Homo sapiens
TAX016771
GO:0007077 biological process mitotic nuclear envelope disassembly The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell (more detail) 12 NA Homo sapiens
TAX021073
GO:0031597 cellular component cytosolic proteasome complex A proteasome complex found in the cytosol of a cell. (more detail) 12 NA Homo sapiens
TAX016508
GO:0006662 biological process glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two orga (more detail) 12 NA Homo sapiens
IEI011402
Protein protein interactors of human gene RNF150 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF150 (SwissProt ID (more detail) 12 17535438 Homo sapiens
IEI014170
Protein protein interactors of human gene TRAF7 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRAF7 (SwissProt ID= (more detail) 12 17535438 Homo sapiens
TAX017513
GO:0009111 biological process vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unre (more detail) 12 NA Homo sapiens
MOX012907
Genes associated with Computational Drug Signature Go 6976 Genes associated with Computational Drug Signature Go 6976, curated by the Drug Signature Database ( (more detail) 12 25990557 Homo sapiens
WAG001527
RNA Polymerase III Chain Elongation (more detail) 12 NA Homo sapiens
MOX001010
Genes associated with Computational Drug Signature ANILINE Genes associated with Computational Drug Signature ANILINE, curated by the Drug Signature Database ( (more detail) 12 25990557 Homo sapiens
MOX002238
Genes associated with Computational Drug Signature 2',4' Dihydroxychalcone Genes associated with Computational Drug Signature 2',4'-Dihydroxychalcone, curated by the Drug Sign (more detail) 12 25990557 Homo sapiens
MOX005726
Genes associated with Computational Drug Signature 2 mercaptoethanol Genes associated with Computational Drug Signature 2-mercaptoethanol, curated by the Drug Signature (more detail) 12 25990557 Homo sapiens
WAG001448
Nonhomologous end joining Nonhomologous end joining (NHEJ) elimites D double-strand breaks (DSBs) by direct ligation. NHEJ inv (more detail) 12 NA Homo sapiens
WIG001157
Genes involved in Resolution of AP sites via the single nucleotide replacement pathway (more detail) 12 NA Homo sapiens
TAX000232
Genes annotated by the GO term GO:0006041. The chemical reactions and pathways involving glucosamine (2 amino 2 deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. (more detail) 12 NA Homo sapiens
WIG000570
Non homologous end joining Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ (more detail) 12 NA Homo sapiens
MOX000494
Genes associated with Computational Drug Signature Norharman Genes associated with Computational Drug Signature Norharman, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
WAG000909
RNA Polymerase III Transcription Termination (more detail) 12 NA Homo sapiens
WIG000415
Rab GTPases Mark Targets In The Endocytotic Machinery The eukaryotic cell contains compartments with distinct functions bounded by lipid bilayer membranes (more detail) 12 NA Homo sapiens
WIG001252
Genes involved in Synthesis of PIPs at the early endosome membrane (more detail) 12 NA Homo sapiens
WIG000826
Genes involved in ERKs are inactivated (more detail) 12 NA Homo sapiens
FEX003089
StemCell Lim08 14genes Table 4 Genes associated with lipid biosynthesis (more detail) 12 18510698 Homo sapiens
MOX014858
Genes associated with Computational Drug Signature Ro 4396686 Genes associated with Computational Drug Signature Ro-4396686, curated by the Drug Signature Databas (more detail) 12 25990557 Homo sapiens
MOX004548
Genes associated with Computational Drug Signature PLATINUM Genes associated with Computational Drug Signature PLATINUM, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
MOX003542
Genes associated with Computational Drug Signature CID755673 Genes associated with Computational Drug Signature CID755673, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
MEX000218
Genes associated with Approved Drug metolazone Genes associated with Approved Drug metolazone, curated by the Drug Signature Database (DSigDB). (more detail) 12 25990557 Homo sapiens
WIG000686
Genes involved in alpha linolenic acid (ALA) metabolism (more detail) 12 NA Homo sapiens
MOX012992
Genes associated with Computational Drug Signature heme Genes associated with Computational Drug Signature heme, curated by the Drug Signature Database (DSi (more detail) 12 25990557 Homo sapiens
PEX000411
AAA: ATPase family associated with various cellular activities (AAA) AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, o (more detail) 12 NA Homo sapiens
WAG000308
RNA Polymerase III Transcription (more detail) 12 NA Homo sapiens
WAG000705
RNA Polymerase I Transcription Termination (more detail) 20 NA Homo sapiens
MOX003534
Genes associated with Computational Drug Signature NVP BEZ235 Genes associated with Computational Drug Signature NVP-BEZ235, curated by the Drug Signature Databas (more detail) 20 25990557 Homo sapiens
WAG000410
role of erbb2 in signal transduction and oncology Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor recep (more detail) 20 NA Homo sapiens
WAG000115
RNA Polymerase I Promoter Clearance (more detail) 20 NA Homo sapiens
GEX001252
overall effect overall effect associated genes. PAGER constructed this gene set by grouping all genes which are ass (more detail) 20 NA Homo sapiens
MOX003047
Genes associated with Computational Drug Signature Dutasteride Genes associated with Computational Drug Signature Dutasteride, curated by the Drug Signature Databa (more detail) 20 25990557 Homo sapiens
WAG001545
RNA Polymerase I Promoter Escape (more detail) 20 NA Homo sapiens
GEX000631
endometrial cancer endometrial cancer associated genes. PAGER constructed this gene set by grouping all genes which are (more detail) 20 NA Homo sapiens
WAG000314
RNA Polymerase I Transcription Initiation (more detail) 20 NA Homo sapiens
MOX004700
Genes associated with Computational Drug Signature sulfinpyrazone Genes associated with Computational Drug Signature sulfinpyrazone, curated by the Drug Signature Dat (more detail) 20 25990557 Homo sapiens
MOX004228
Genes associated with Computational Drug Signature Isatin Genes associated with Computational Drug Signature Isatin, curated by the Drug Signature Database (D (more detail) 20 25990557 Homo sapiens
WIG001177
Genes involved in RNA Polymerase I Transcription Termination (more detail) 20 NA Homo sapiens
GEX000989
leukemia leukemia associated genes. PAGER constructed this gene set by grouping all genes which are associate (more detail) 20 NA Homo sapiens
MEX002755
Genes associated with Perturbagen Signature C 75 Genes associated with Perturbagen Signature C-75, curated by the Drug Signature Database (DSigDB). (more detail) 20 25990557 Homo sapiens
WAG001465
ccr3 signaling in eosinophils Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic rea (more detail) 20 NA Homo sapiens
TAX020902
GO:0031293 biological process membrane protein intracellular domain proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domai (more detail) 20 NA Homo sapiens
IEI006353
Protein protein interactors of human gene IL3RA from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene IL3RA (SwissProt ID= (more detail) 20 17535438 Homo sapiens
IEI010920
Protein protein interactors of human gene RABGGTB from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RABGGTB (SwissProt I (more detail) 20 17535438 Homo sapiens
IEI004615
Protein protein interactors of human gene FBXL15 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene FBXL15 (SwissProt ID (more detail) 20 17535438 Homo sapiens
IEI010130
Protein protein interactors of human gene PLXNB1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PLXNB1 (SwissProt ID (more detail) 20 17535438 Homo sapiens
IEI006101
Protein protein interactors of human gene HTR2A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene HTR2A (SwissProt ID= (more detail) 20 17535438 Homo sapiens
MOX016093
Genes associated with Computational Drug Signature nimesulide Genes associated with Computational Drug Signature nimesulide, curated by the Drug Signature Databas (more detail) 18 25990557 Homo sapiens
WAG001026
ras signaling pathway Ras activates many sigling cascades. Here we illustrate some of the well-characterized cascades in (more detail) 18 NA Homo sapiens
WIG000649
Genes involved in ABCA transporters in lipid homeostasis (more detail) 18 NA Homo sapiens
MAX002049
Composition of the 2 MDa human TFTC complex containing KAT2A [GeneID=2648] . Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific transcriptional (more detail) 18 NA Homo sapiens
MOX004647
Genes associated with Computational Drug Signature selegiline Genes associated with Computational Drug Signature selegiline, curated by the Drug Signature Databas (more detail) 18 25990557 Homo sapiens
MOX007450
Genes associated with Computational Drug Signature Caffeic acid phenethyl ester Genes associated with Computational Drug Signature Caffeic acid phenethyl ester, curated by the Drug (more detail) 18 25990557 Homo sapiens
WAG000431
chrebp regulation by carbohydrates and camp (more detail) 18 NA Homo sapiens
WIG000443
Telomeres, Telomerase, Cellular Aging, and Immortality Telomeres, which define the ends of chromosomes, consist of short, tandemly repeated DNA sequences l (more detail) 18 NA Homo sapiens
WIG001150
Genes involved in Regulation of signaling by CBL (more detail) 18 NA Homo sapiens
MOX001255
Genes associated with Computational Drug Signature 76180 96 6 Genes associated with Computational Drug Signature 76180-96-6, curated by the Drug Signature Databas (more detail) 18 25990557 Homo sapiens
WIG001120
Genes involved in Pyruvate metabolism (more detail) 18 NA Homo sapiens
WIG000750
Genes involved in cGMP effects (more detail) 18 NA Homo sapiens
TAX014115
GO:0002204 biological process somatic recombination of immunoglobulin genes involved in immune response The process in which immunoglobulin genes are formed through recombination of the germline genetic e (more detail) 18 NA Homo sapiens
MOX015097
Genes associated with Computational Drug Signature simvastatin Genes associated with Computational Drug Signature simvastatin, curated by the Drug Signature Databa (more detail) 18 25990557 Homo sapiens
WIG001092
Genes involved in Post chaperonin tubulin folding pathway (more detail) 18 NA Homo sapiens
MOX012876
Genes associated with Computational Drug Signature GLYCYRRHETINIC ACID Genes associated with Computational Drug Signature GLYCYRRHETINIC ACID, curated by the Drug Signatur (more detail) 18 25990557 Homo sapiens
TAX014116
GO:0002208 biological process somatic diversification of immunoglobulins involved in immune response The somatic process that results in the generation of sequence diversity of immunoglobulins after in (more detail) 18 NA Homo sapiens
TAX013563
GO:0000966 biological process RNA 5' end processing Any process involved in forming the mature 5' end of an RNA molecule. (more detail) 18 NA Homo sapiens
IEI004620
Protein protein interactors of human gene FBXL2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene FBXL2 (SwissProt ID= (more detail) 18 17535438 Homo sapiens
TAX025002
GO:0045190 biological process isotype switching The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immuno (more detail) 18 NA Homo sapiens
IEI014814
Protein protein interactors of human gene UTP18 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UTP18 (SwissProt ID= (more detail) 18 17535438 Homo sapiens
TAX021317
GO:0032069 biological process regulation of nuclease activity Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of est (more detail) 18 NA Homo sapiens
IEI011251
Protein protein interactors of human gene RGS19 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RGS19 (SwissProt ID= (more detail) 18 17535438 Homo sapiens
WIG000096
IL5 mediated signaling events (more detail) 14 NA Homo sapiens
WIG000167
S1P4 pathway (more detail) 14 NA Homo sapiens
MEX000169
Genes associated with Approved Drug indapamide Genes associated with Approved Drug indapamide, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
WAG001077
Apoptotic cleavage of cellular proteins (more detail) 14 NA Homo sapiens
MOX017531
Genes associated with Computational Drug Signature piperazine Genes associated with Computational Drug Signature piperazine, curated by the Drug Signature Databas (more detail) 14 25990557 Homo sapiens
PEX001173
zf C3HC4 3: Zinc finger, C3HC4 type (RING finger) (more detail) 14 NA Homo sapiens
FOX000733
Genes in the cancer module 445 (more detail) 14 NA Homo sapiens
MOX007449
Genes associated with Computational Drug Signature caffeic acid Genes associated with Computational Drug Signature caffeic acid, curated by the Drug Signature Datab (more detail) 14 25990557 Homo sapiens
MOX004962
Genes associated with Computational Drug Signature fluvoxamine Genes associated with Computational Drug Signature fluvoxamine, curated by the Drug Signature Databa (more detail) 14 25990557 Homo sapiens
TAX000213
Genes annotated by the GO term GO:0006633. The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. (more detail) 14 NA Homo sapiens
TAX000050
Genes annotated by the GO term GO:0043284. The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins. (more detail) 14 NA Homo sapiens
WIG000179
Ras signaling in the CD4+ TCR pathway (more detail) 14 NA Homo sapiens
WIG001235
Genes involved in SOS mediated signalling (more detail) 14 NA Homo sapiens
IEI011282
Protein protein interactors of human gene RHOBTB2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RHOBTB2 (SwissProt I (more detail) 14 17535438 Homo sapiens
IEI007785
Protein protein interactors of human gene MCF2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MCF2 (SwissProt ID=P (more detail) 14 17535438 Homo sapiens
TAX028525
GO:0061647 biological process histone H3 K9 modification The modification of histone H3 at a lysine in position 9 of the histone. (more detail) 14 NA Homo sapiens
IEI011375
Protein protein interactors of human gene RNF103 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF103 (SwissProt ID (more detail) 14 17535438 Homo sapiens
IEI007094
Protein protein interactors of human gene KSR2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene KSR2 (SwissProt ID=Q (more detail) 14 17535438 Homo sapiens
TAX016072
GO:0006012 biological process galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose (more detail) 14 NA Homo sapiens
IEI003359
Protein protein interactors of human gene DCLRE1C from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DCLRE1C (SwissProt I (more detail) 14 17535438 Homo sapiens
IEI005680
Protein protein interactors of human gene H3 5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene H3-5 (SwissProt ID=Q (more detail) 14 17535438 Homo sapiens
IEI001350
Protein protein interactors of human gene BIRC8 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene BIRC8 (SwissProt ID= (more detail) 14 17535438 Homo sapiens
TAX024643
GO:0044247 biological process cellular polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (more detail) 14 NA Homo sapiens
WAG000211
sprouty regulation of tyrosine kinase signals Four different members of the Sprouty protein family block the cellular proliferation and differenti (more detail) 16 NA Homo sapiens
MOX003413
Genes associated with Computational Drug Signature NVP AEW541 Genes associated with Computational Drug Signature NVP-AEW541, curated by the Drug Signature Databas (more detail) 16 25990557 Homo sapiens
TAX000339
Genes annotated by the GO term GO:0007018. Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. (more detail) 16 NA Homo sapiens
MOX004352
Genes associated with Computational Drug Signature N Methyl N nitrosourea Genes associated with Computational Drug Signature N-Methyl-N-nitrosourea, curated by the Drug Signa (more detail) 16 25990557 Homo sapiens
TAX001147
Genes annotated by the GO term GO:0008144. Interacting selectively with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. (more detail) 16 NA Homo sapiens
TAX023483
GO:0038084 biological process vascular endothelial growth factor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF (more detail) 16 NA Homo sapiens
IEI002734
Protein protein interactors of human gene CNOT4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CNOT4 (SwissProt ID= (more detail) 16 17535438 Homo sapiens
TAX022017
GO:0033176 cellular component proton transporting V type ATPase complex A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of prot (more detail) 16 NA Homo sapiens
TAX016458
GO:0006595 biological process polyamine metabolic process The chemical reactions and pathways involving polyamines, any organic compound containing two or mor (more detail) 16 NA Homo sapiens
MEX001211
Genes associated with Kinase Inhibitor purvalanol A Genes associated with Kinase Inhibitor purvalanol A, curated by the Drug Signature Database (DSigDB) (more detail) 9 25990557 Homo sapiens
WAG000888
Lagging Strand Synthesis (more detail) 9 NA Homo sapiens
WIG001309
Genes involved in Tryptophan catabolism (more detail) 9 NA Homo sapiens
MEX001403
Genes associated with Kinase Inhibitor NCGC00346961 01 Genes associated with Kinase Inhibitor NCGC00346961-01, curated by the Drug Signature Database (DSig (more detail) 9 25990557 Homo sapiens
MEX001887
Genes associated with Kinase Inhibitor aminopurvalanol A Genes associated with Kinase Inhibitor aminopurvalanol A, curated by the Drug Signature Database (DS (more detail) 9 25990557 Homo sapiens
MEX001911
Genes associated with Kinase Inhibitor ML 9 Genes associated with Kinase Inhibitor ML-9, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001682
Genes associated with Kinase Inhibitor 7 Hydroxystaurosporine Genes associated with Kinase Inhibitor 7-Hydroxystaurosporine, curated by the Drug Signature Databas (more detail) 9 25990557 Homo sapiens
MEX002078
Genes associated with Kinase Inhibitor Kinome 2052 Genes associated with Kinase Inhibitor Kinome_2052, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001793
Genes associated with Kinase Inhibitor CHEMBL1979577 Genes associated with Kinase Inhibitor CHEMBL1979577, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MOX000596
Genes associated with Computational Drug Signature Mycotoxin HT 2 Genes associated with Computational Drug Signature Mycotoxin HT 2, curated by the Drug Signature Dat (more detail) 9 25990557 Homo sapiens
MOX007345
Genes associated with Computational Drug Signature BMS 754807 Genes associated with Computational Drug Signature BMS-754807, curated by the Drug Signature Databas (more detail) 9 25990557 Homo sapiens
TAX014054
GO:0002084 biological process protein depalmitoylation The removal of palymitoyl groups from a lipoprotein. (more detail) 9 NA Homo sapiens
PEX001977
Peptidase C14: Caspase domain (more detail) 9 NA Homo sapiens
PEX001484
Rhodanese: Rhodanese like domain Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain (more detail) 9 NA Homo sapiens
PEX002198
GST C 3: Glutathione S transferase, C terminal domain This domain is closely related to Pfam:PF00043. (more detail) 9 NA Homo sapiens
PEX001660
HECT: HECT domain (ubiquitin transferase) The name HECT comes from Homologous to the E6-AP Carboxyl Terminus. (more detail) 9 NA Homo sapiens
WAG001548
Telomere C strand (Lagging Strand) Synthesis (more detail) 9 NA Homo sapiens
MEX001433
Genes associated with Kinase Inhibitor S1107 Selleck Genes associated with Kinase Inhibitor S1107_Selleck, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MEX001377
Genes associated with Kinase Inhibitor Kinome 468 Genes associated with Kinase Inhibitor Kinome_468, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001901
Genes associated with Kinase Inhibitor Kinome 709 Genes associated with Kinase Inhibitor Kinome_709, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002033
Genes associated with Kinase Inhibitor Sorafenib Genes associated with Kinase Inhibitor Sorafenib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002191
Genes associated with Kinase Inhibitor CHEMBL241517 Genes associated with Kinase Inhibitor CHEMBL241517, curated by the Drug Signature Database (DSigDB) (more detail) 9 25990557 Homo sapiens
MOX002520
Genes associated with Computational Drug Signature Risedronate Genes associated with Computational Drug Signature Risedronate, curated by the Drug Signature Databa (more detail) 9 25990557 Homo sapiens
MOX014196
Genes associated with Computational Drug Signature nu6102 Genes associated with Computational Drug Signature nu6102, curated by the Drug Signature Database (D (more detail) 9 25990557 Homo sapiens
MOX017827
Genes associated with Computational Drug Signature tetrahydrofolate Genes associated with Computational Drug Signature tetrahydrofolate, curated by the Drug Signature D (more detail) 9 25990557 Homo sapiens
WIG000324
Feeder Pathways for Glycolysis The glycolytic pathway begins with the simple sugar glucose and leads to pyruvate and eventually the (more detail) 9 NA Homo sapiens
TAX000764
Genes annotated by the GO term GO:0030148. The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long chain amine diol sphingosine or a closely related base (a sphingoid). (more detail) 9 NA Homo sapiens
TAX000576
Genes annotated by the GO term GO:0006220. The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5' hydroxyl group of its glycose moiety. (more detail) 9 NA Homo sapiens
MEX001449
Genes associated with Kinase Inhibitor CHEMBL47203 Genes associated with Kinase Inhibitor CHEMBL47203, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001260
Genes associated with Kinase Inhibitor Sunitinib Genes associated with Kinase Inhibitor Sunitinib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001354
Genes associated with Kinase Inhibitor Dasatinib Genes associated with Kinase Inhibitor Dasatinib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002068
Genes associated with Kinase Inhibitor BX 320 Genes associated with Kinase Inhibitor BX-320, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MOX006632
Genes associated with Computational Drug Signature Adenosine diphosphate Genes associated with Computational Drug Signature Adenosine diphosphate, curated by the Drug Signat (more detail) 9 25990557 Homo sapiens
MOX013420
Genes associated with Computational Drug Signature leucettamine B Genes associated with Computational Drug Signature leucettamine B, curated by the Drug Signature Dat (more detail) 9 25990557 Homo sapiens
FEX001900
Lung Yabuki07 10genes Table 4. ABC transporter genes highly expressed in drug-resistant cell line NCI-H460/PTX250 relative (more detail) 9 17284363 Homo sapiens
WAG000293
Leading Strand Synthesis (more detail) 9 NA Homo sapiens
WAG001128
Processive synthesis on the lagging strand (more detail) 9 NA Homo sapiens
WAG000332
mRNA Processing (more detail) 9 NA Homo sapiens
MAX002047
Composition of the 2 MDa human PCAF complex. Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific transcriptional (more detail) 9 NA Homo sapiens
WIG002026
Benzo(a)pyrene metabolism Benzo(a)pyrene metabolism (more detail) 9 NA Homo sapiens
WIG001347
Erlotinib Pathway, Pharmacokinetics Model human liver cell showing genes involved in the transportation and metabolism of Erlotinib. (more detail) 9 NA Homo sapiens
MEX001253
Genes associated with Kinase Inhibitor Kinome 242 Genes associated with Kinase Inhibitor Kinome_242, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002218
Genes associated with Kinase Inhibitor BX 517 Genes associated with Kinase Inhibitor BX-517, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001563
Genes associated with Kinase Inhibitor Kinome 2079 Genes associated with Kinase Inhibitor Kinome_2079, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002231
Genes associated with Kinase Inhibitor 1 NM PP1 Genes associated with Kinase Inhibitor 1-NM-PP1, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001691
Genes associated with Kinase Inhibitor Kinome 413 Genes associated with Kinase Inhibitor Kinome_413, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002402
Genes associated with Kinase Inhibitor Lapatinib Genes associated with Kinase Inhibitor Lapatinib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002147
Genes associated with Kinase Inhibitor CHEMBL1979883 Genes associated with Kinase Inhibitor CHEMBL1979883, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MOX002712
Genes associated with Computational Drug Signature 7 Hydroxy 4 (trifluoromethyl)coumarin Genes associated with Computational Drug Signature 7-Hydroxy-4-(trifluoromethyl)coumarin, curated by (more detail) 9 25990557 Homo sapiens
TAX014727
GO:0003374 biological process dynamin family protein polymerization involved in mitochondrial fission The process of creating dynamin protein family polymers, compounds composed of a large number of dyn (more detail) 9 NA Homo sapiens
TAX013597
GO:0001054 molecular function RNA polymerase I activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA (more detail) 9 NA Homo sapiens
PEX000646
Exo endo phos: Endonuclease/Exonuclease/phosphatase family This large family of proteins includes magnesium dependent endonucleases and a large number of phosp (more detail) 9 NA Homo sapiens
WAG000285
DNA strand elongation (more detail) 9 NA Homo sapiens
FEX000430
Breast Park06 11genes ABC transporters Table 2. Differentially expressed ABC transporters ordered by significance (more detail) 9 16752223 Homo sapiens
TAX001384
Genes annotated by the GO term GO:0019783. Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin like sequences from larger leaving groups. (more detail) 9 NA Homo sapiens
MEX001372
Genes associated with Kinase Inhibitor Kinome 1335 Genes associated with Kinase Inhibitor Kinome_1335, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001374
Genes associated with Kinase Inhibitor CHEMBL411903 Genes associated with Kinase Inhibitor CHEMBL411903, curated by the Drug Signature Database (DSigDB) (more detail) 9 25990557 Homo sapiens
MEX001289
Genes associated with Kinase Inhibitor SU11274 Genes associated with Kinase Inhibitor SU11274, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001071
Genes associated with Approved Drug belinostat Genes associated with Approved Drug belinostat, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX000784
Genes associated with Approved Drug naproxen Genes associated with Approved Drug naproxen, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002000
Genes associated with Kinase Inhibitor CHEMBL1993941 Genes associated with Kinase Inhibitor CHEMBL1993941, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MEX002183
Genes associated with Kinase Inhibitor PDGF Receptor Tyrosine Kinase Inhibitor V Genes associated with Kinase Inhibitor PDGF Receptor Tyrosine Kinase Inhibitor V, curated by the Dru (more detail) 9 25990557 Homo sapiens
MEX000164
Genes associated with Approved Drug phenelzine Genes associated with Approved Drug phenelzine, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MOX001138
Genes associated with Computational Drug Signature 4 Hydroxyestrone Genes associated with Computational Drug Signature 4-Hydroxyestrone, curated by the Drug Signature D (more detail) 9 25990557 Homo sapiens
MOX003016
Genes associated with Computational Drug Signature OSW 1 Genes associated with Computational Drug Signature OSW-1, curated by the Drug Signature Database (DS (more detail) 9 25990557 Homo sapiens
TAX014726
GO:0003373 biological process dynamin family protein polymerization involved in membrane fission The process of creating dynamin family protein polymers, compounds composed of a large number of dyn (more detail) 9 NA Homo sapiens
TAX013710
GO:0001574 biological process ganglioside biosynthetic process The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying (more detail) 9 NA Homo sapiens
PEX002570
zf RING 2: Ring finger domain (more detail) 9 NA Homo sapiens
WIG002010
Heme Biosynthesis Heme Biosynthesis (more detail) 9 NA Homo sapiens
WAG001543
Pyrimidine biosynthesis (interconversion) (more detail) 9 NA Homo sapiens
WIG001116
Genes involved in Purine ribonucleoside monophosphate biosynthesis (more detail) 9 NA Homo sapiens
MEX001398
Genes associated with Kinase Inhibitor JNK Inhibitor V Genes associated with Kinase Inhibitor JNK Inhibitor V, curated by the Drug Signature Database (DSig (more detail) 9 25990557 Homo sapiens
MEX001823
Genes associated with Kinase Inhibitor GW843682X Genes associated with Kinase Inhibitor GW843682X, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MOX000027
Genes associated with Computational Drug Signature N phenylanthranilic acid Genes associated with Computational Drug Signature N-phenylanthranilic acid, curated by the Drug Sig (more detail) 9 25990557 Homo sapiens
MOX012197
Genes associated with Computational Drug Signature Debromohymenialdisine Genes associated with Computational Drug Signature Debromohymenialdisine, curated by the Drug Signat (more detail) 9 25990557 Homo sapiens
WAG001367
Ribonucleotide salvage (more detail) 9 NA Homo sapiens
GEX000594
dna dna associated genes. PAGER constructed this gene set by grouping all genes which are associated wit (more detail) 9 NA Homo sapiens
WIG000551
Limonene and pinene degradation (more detail) 9 NA Homo sapiens
MEX001380
Genes associated with Kinase Inhibitor lfm a13 Genes associated with Kinase Inhibitor lfm-a13, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001049
Genes associated with Approved Drug sunitinib malate Genes associated with Approved Drug sunitinib malate, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
MEX002104
Genes associated with Kinase Inhibitor PF 477736 Genes associated with Kinase Inhibitor PF-477736, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX002119
Genes associated with Kinase Inhibitor GW809897X Genes associated with Kinase Inhibitor GW809897X, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
PEX001840
EphA2 TM: Ephrin type A receptor 2 transmembrane domain Epha2_TM represents the left-handed dimer transmembrane domain of of EphA2 receptor. This domain ol (more detail) 9 NA Homo sapiens
TAX001241
Genes annotated by the GO term GO:0004709. Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. (more detail) 9 NA Homo sapiens
MEX002310
Genes associated with Kinase Inhibitor Tozasertib Genes associated with Kinase Inhibitor Tozasertib, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MEX001888
Genes associated with Kinase Inhibitor Oxindole Based Inhibitor 54 Genes associated with Kinase Inhibitor Oxindole-Based Inhibitor 54, curated by the Drug Signature Da (more detail) 9 25990557 Homo sapiens
MEX002121
Genes associated with Kinase Inhibitor CHEMBL2062937 Genes associated with Kinase Inhibitor CHEMBL2062937, curated by the Drug Signature Database (DSigDB (more detail) 9 25990557 Homo sapiens
TAX016398
GO:0006531 biological process aspartate metabolic process The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-ami (more detail) 9 NA Homo sapiens
TAX016405
GO:0006538 biological process glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopen (more detail) 9 NA Homo sapiens
TAX016066
GO:0006002 biological process fructose 6 phosphate metabolic process The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantio (more detail) 9 NA Homo sapiens
TAX022021
GO:0033180 cellular component proton transporting V type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysi (more detail) 9 NA Homo sapiens
TAX029262
GO:0071028 biological process nuclear mRNA surveillance The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nu (more detail) 9 NA Homo sapiens
TAX022781
GO:0035252 molecular function UDP xylosyltransferase activity Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. (more detail) 9 NA Homo sapiens
TAX017104
GO:0008174 molecular function mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in (more detail) 9 NA Homo sapiens
TAX017531
GO:0009133 biological process nucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compou (more detail) 9 NA Homo sapiens
TAX020953
GO:0031371 cellular component ubiquitin conjugating enzyme complex Any complex that possesses ubiquitin conjugating enzyme activity. (more detail) 9 NA Homo sapiens
TAX025466
GO:0046130 biological process purine ribonucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucle (more detail) 9 NA Homo sapiens
TAX027416
GO:0052646 biological process alditol phosphate metabolic process The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alco (more detail) 9 NA Homo sapiens
TAX032254
GO:1901750 biological process leukotriene D4 biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene D4. (more detail) 9 NA Homo sapiens
TAX014916
GO:0004017 molecular function adenylate kinase activity Catalysis of the reaction: ATP + AMP = 2 ADP. (more detail) 9 NA Homo sapiens
TAX016427
GO:0006560 biological process proline metabolic process The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyc (more detail) 9 NA Homo sapiens
TAX023363
GO:0036374 molecular function glutathione hydrolase activity Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. (more detail) 9 NA Homo sapiens
TAX022780
GO:0035251 molecular function UDP glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. (more detail) 9 NA Homo sapiens
TAX017074
GO:0008121 molecular function ubiquinol cytochrome c reductase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to th (more detail) 9 NA Homo sapiens
TAX017606
GO:0009215 biological process purine deoxyribonucleoside triphosphate metabolic process The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound co (more detail) 9 NA Homo sapiens
TAX025772
GO:0046855 biological process inositol phosphate dephosphorylation The process of removing a phosphate group from any mono- or polyphosphorylated inositol. (more detail) 9 NA Homo sapiens
TAX027417
GO:0052650 molecular function NADP retinol dehydrogenase activity Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. (more detail) 9 NA Homo sapiens
TAX016094
GO:0006048 biological process UDP N acetylglucosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substan (more detail) 9 NA Homo sapiens
TAX016183
GO:0006198 biological process cAMP catabolic process The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, a (more detail) 9 NA Homo sapiens
TAX023797
GO:0042364 biological process water soluble vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins (more detail) 9 NA Homo sapiens
TAX019706
GO:0019388 biological process galactose catabolic process The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto- (more detail) 9 NA Homo sapiens
TAX021505
GO:0032389 cellular component MutLalpha complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In h (more detail) 9 NA Homo sapiens
TAX019156
GO:0016670 molecular function oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hy (more detail) 9 NA Homo sapiens
TAX026609
GO:0050812 biological process regulation of acyl CoA biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resu (more detail) 9 NA Homo sapiens
TAX019246
GO:0016832 molecular function aldehyde lyase activity Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl gro (more detail) 9 NA Homo sapiens
TAX025828
GO:0046951 biological process ketone body biosynthetic process The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the thre (more detail) 9 NA Homo sapiens
TAX021046
GO:0031545 molecular function peptidyl proline 4 dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-pro (more detail) 9 NA Homo sapiens
TAX025880
GO:0047144 molecular function 2 acylglycerol 3 phosphate O acyltransferase activity Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA. (more detail) 9 NA Homo sapiens
TAX032862
GO:1903265 biological process positive regulation of tumor necrosis factor mediated signaling pathway Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-media (more detail) 9 NA Homo sapiens
TAX023788
GO:0042354 biological process L fucose metabolic process The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in (more detail) 9 NA Homo sapiens
TAX024563
GO:0043996 molecular function histone acetyltransferase activity (H4 K8 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acety (more detail) 9 NA Homo sapiens
TAX019137
GO:0016634 molecular function oxidoreductase activity, acting on the CH CH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or el (more detail) 9 NA Homo sapiens
TAX019181
GO:0016725 molecular function oxidoreductase activity, acting on CH or CH2 groups Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or elec (more detail) 9 NA Homo sapiens
TAX025617
GO:0046520 biological process sphingoid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of comp (more detail) 9 NA Homo sapiens
TAX015558
GO:0005024 molecular function transforming growth factor beta activated receptor activity Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side (more detail) 9 NA Homo sapiens
TAX032253
GO:1901748 biological process leukotriene D4 metabolic process The chemical reactions and pathways involving leukotriene D4. (more detail) 9 NA Homo sapiens
TAX023789
GO:0042355 biological process L fucose catabolic process The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose). (more detail) 9 NA Homo sapiens
TAX029193
GO:0070933 biological process histone H4 deacetylation The modification of histone H4 by the removal of one or more acetyl groups. (more detail) 9 NA Homo sapiens
TAX017556
GO:0009158 biological process ribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a (more detail) 9 NA Homo sapiens
TAX017455
GO:0008970 molecular function phospholipase A1 activity Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. (more detail) 9 NA Homo sapiens
TAX024562
GO:0043995 molecular function histone acetyltransferase activity (H4 K5 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acety (more detail) 9 NA Homo sapiens
TAX025842
GO:0046972 molecular function histone acetyltransferase activity (H4 K16 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acet (more detail) 9 NA Homo sapiens
TAX014794
GO:0003810 molecular function protein glutamine gamma glutamyltransferase activity Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This re (more detail) 9 NA Homo sapiens
TAX015240
GO:0004579 molecular function dolichyl diphosphooligosaccharide protein glycotransferase activity Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl dipho (more detail) 9 NA Homo sapiens
TAX014921
GO:0004022 molecular function alcohol dehydrogenase (NAD) activity Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. (more detail) 9 NA Homo sapiens
TAX015321
GO:0004690 molecular function cyclic nucleotide dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the pres (more detail) 9 NA Homo sapiens
TAX017344
GO:0008553 molecular function proton exporting ATPase activity, phosphorylative mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: (more detail) 9 NA Homo sapiens
TAX014994
GO:0004126 molecular function cytidine deaminase activity Catalysis of the reaction: cytidine + H2O = uridine + NH3. (more detail) 9 NA Homo sapiens
TAX017566
GO:0009169 biological process purine ribonucleoside monophosphate catabolic process The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphat (more detail) 9 NA Homo sapiens
TAX019162
GO:0016681 molecular function oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts (more detail) 9 NA Homo sapiens
TAX019228
GO:0016803 molecular function ether hydrolase activity Catalysis of the hydrolysis of an ether bond, -O-. (more detail) 9 NA Homo sapiens
TAX027430
GO:0052696 biological process flavonoid glucuronidation The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucu (more detail) 9 NA Homo sapiens
TAX025597
GO:0046487 biological process glyoxylate metabolic process The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. (more detail) 9 NA Homo sapiens
TAX016098
GO:0006054 biological process N acetylneuraminate metabolic process The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5- (more detail) 9 NA Homo sapiens
TAX016157
GO:0006152 biological process purine nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family (more detail) 9 NA Homo sapiens
IEI011435
Protein protein interactors of human gene RNF26 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF26 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
IEI012886
Protein protein interactors of human gene SPINK5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SPINK5 (SwissProt ID (more detail) 9 17535438 Homo sapiens
TAX023754
GO:0042285 molecular function xylosyltransferase activity Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate (more detail) 9 NA Homo sapiens
TAX016501
GO:0006655 biological process phosphatidylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a cl (more detail) 9 NA Homo sapiens
TAX017426
GO:0008821 molecular function crossover junction endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossov (more detail) 9 NA Homo sapiens
TAX019674
GO:0019317 biological process fucose catabolic process The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose). (more detail) 9 NA Homo sapiens
TAX027425
GO:0052659 molecular function inositol 1,3,4,5 tetrakisphosphate 5 phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-t (more detail) 9 NA Homo sapiens
TAX025943
GO:0047498 molecular function calcium dependent phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. (more detail) 9 NA Homo sapiens
TAX014815
GO:0003857 molecular function 3 hydroxyacyl CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). (more detail) 9 NA Homo sapiens
IEI001010
Protein protein interactors of human gene ATAD5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ATAD5 (SwissProt ID= (more detail) 11 17535438 Homo sapiens
TAX016136
GO:0006107 biological process oxaloacetate metabolic process The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an imp (more detail) 11 NA Homo sapiens
IEI007759
Protein protein interactors of human gene MBD3L2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MBD3L2 (SwissProt ID (more detail) 11 17535438 Homo sapiens
TAX018871
GO:0016114 biological process terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class (more detail) 11 NA Homo sapiens
TAX016053
GO:0005984 biological process disaccharide metabolic process The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharid (more detail) 11 NA Homo sapiens
TAX024380
GO:0043471 biological process regulation of cellular carbohydrate catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways res (more detail) 11 NA Homo sapiens
TAX016376
GO:0006501 biological process C terminal protein lipidation The covalent attachment of a lipid group to the carboxy terminus of a protein. (more detail) 11 NA Homo sapiens
IEI014460
Protein protein interactors of human gene TUB from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TUB (SwissProt ID=P5 (more detail) 11 17535438 Homo sapiens
TAX032593
GO:1902644 biological process tertiary alcohol metabolic process The chemical reactions and pathways involving tertiary alcohol. (more detail) 11 NA Homo sapiens
TAX030586
GO:0090646 biological process mitochondrial tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an ami (more detail) 11 NA Homo sapiens
TAX016350
GO:0006465 biological process signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific l (more detail) 11 NA Homo sapiens
TAX021305
GO:0032048 biological process cardiolipin metabolic process The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. (more detail) 11 NA Homo sapiens
TAX025031
GO:0045240 cellular component dihydrolipoyl dehydrogenase complex A protein complex that possesses alpha-ketoglutarate dehydrogenase activity. (more detail) 11 NA Homo sapiens
TAX029528
GO:0071545 biological process inositol phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6 (more detail) 11 NA Homo sapiens
TAX016420
GO:0006553 biological process lysine metabolic process The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. (more detail) 11 NA Homo sapiens
WIG001271
Genes involved in The activation of arylsulfatases (more detail) 11 NA Homo sapiens
TAX001266
Genes annotated by the GO term GO:0004715. Catalysis of the reaction: ATP + a protein L tyrosine = ADP + a protein L tyrosine phosphate. (more detail) 11 NA Homo sapiens
TAX001071
Genes annotated by the GO term GO:0043531. Interacting selectively with ADP, adenosine 5' diphosphate. (more detail) 11 NA Homo sapiens
TAX013995
GO:0002003 biological process angiotensin maturation The process leading to the attainment of the full functional capacity of angiotensin by conversion o (more detail) 11 NA Homo sapiens
MOX017337
Genes associated with Computational Drug Signature MOCO Genes associated with Computational Drug Signature MOCO, curated by the Drug Signature Database (DSi (more detail) 11 25990557 Homo sapiens
GEX001017
liver cancer liver cancer associated genes. PAGER constructed this gene set by grouping all genes which are assoc (more detail) 11 NA Homo sapiens
TAX000443
Genes annotated by the GO term GO:0006044. The chemical reactions and pathways involving N acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein. (more detail) 11 NA Homo sapiens
MOX007489
Genes associated with Computational Drug Signature Carbidopa hydrate Genes associated with Computational Drug Signature Carbidopa hydrate, curated by the Drug Signature (more detail) 11 25990557 Homo sapiens
TAX001393
Genes annotated by the GO term GO:0016229. Catalysis of an oxidation reduction (redox) reaction in which one substrate is a sterol derivative. (more detail) 11 NA Homo sapiens
TAX000233
Genes annotated by the GO term GO:0006007. The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco hexose. (more detail) 11 NA Homo sapiens
MEX000065
Genes associated with Approved Drug chloroquine Genes associated with Approved Drug chloroquine, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX000395
Genes associated with Approved Drug cephalothin Genes associated with Approved Drug cephalothin, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MAX000845
Genes from the lightyellow module which are up regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1 palmitoyl 2 arachidonyl sn 3 glycerophosphorylcholine (oxPAPC). Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) t (more detail) 11 NA Homo sapiens
GEX000227
benzene toxicity benzene toxicity associated genes. PAGER constructed this gene set by grouping all genes which are a (more detail) 11 NA Homo sapiens
WAG000256
Noncanonical Wnt signaling pathway (more detail) 11 NA Homo sapiens
MOX018031
Genes associated with Computational Drug Signature Udp glucuronic acid Genes associated with Computational Drug Signature Udp glucuronic acid, curated by the Drug Signatur (more detail) 11 25990557 Homo sapiens
MOX015148
Genes associated with Computational Drug Signature Sorafenib Genes associated with Computational Drug Signature Sorafenib, curated by the Drug Signature Database (more detail) 11 25990557 Homo sapiens
MOX000118
Genes associated with Computational Drug Signature O ANISIDINE Genes associated with Computational Drug Signature O-ANISIDINE, curated by the Drug Signature Databa (more detail) 11 25990557 Homo sapiens
MOX001108
Genes associated with Computational Drug Signature Arsenic acid Genes associated with Computational Drug Signature Arsenic acid, curated by the Drug Signature Datab (more detail) 11 25990557 Homo sapiens
MEX000334
Genes associated with Approved Drug trichlormethiazide Genes associated with Approved Drug trichlormethiazide, curated by the Drug Signature Database (DSig (more detail) 11 25990557 Homo sapiens
FOX000786
Genes in the cancer module 528 (more detail) 11 NA Homo sapiens
MOX007058
Genes associated with Computational Drug Signature arachidonic acid Genes associated with Computational Drug Signature arachidonic acid, curated by the Drug Signature D (more detail) 17 25990557 Homo sapiens
MOX000593
Genes associated with Computational Drug Signature tranilast Genes associated with Computational Drug Signature tranilast, curated by the Drug Signature Database (more detail) 17 25990557 Homo sapiens
MOX016939
Genes associated with Computational Drug Signature flavin adenine dinucleotide Genes associated with Computational Drug Signature flavin adenine dinucleotide, curated by the Drug (more detail) 17 25990557 Homo sapiens
MOX003972
Genes associated with Computational Drug Signature Diethylcarbamodithioic acid Genes associated with Computational Drug Signature Diethylcarbamodithioic acid, curated by the Drug (more detail) 17 25990557 Homo sapiens
WAG000992
Renin angiotensin system (more detail) 17 NA Homo sapiens
MOX013197
Genes associated with Computational Drug Signature Isokaempferide Genes associated with Computational Drug Signature Isokaempferide, curated by the Drug Signature Dat (more detail) 17 25990557 Homo sapiens
TAX000046
Genes annotated by the GO term GO:0006284. In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. (more detail) 17 NA Homo sapiens
MOX004184
Genes associated with Computational Drug Signature HEXACHLOROBENZENE Genes associated with Computational Drug Signature HEXACHLOROBENZENE, curated by the Drug Signature (more detail) 17 25990557 Homo sapiens
WIG000609
Renin angiotensin system (more detail) 17 NA Homo sapiens
FEX002083
Lung not cancer Harvey06 19genes SuppTable 5: Examples of genes differentially expressed in the small airway epithelium of 10 smokers (more detail) 17 17115125 Homo sapiens
WAG001450
phosphoinositides and their downstream targets Nine currently identified phosphoinositide 3-kises (PI 3-K) constitute a subfamily of lipid kises th (more detail) 17 NA Homo sapiens
MOX001042
Genes associated with Computational Drug Signature Solvent Yellow ?14 Genes associated with Computational Drug Signature Solvent Yellow-?14, curated by the Drug Signature (more detail) 17 25990557 Homo sapiens
IEI007907
Protein protein interactors of human gene METTL22 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene METTL22 (SwissProt I (more detail) 17 17535438 Homo sapiens
IEI013191
Protein protein interactors of human gene SUDS3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SUDS3 (SwissProt ID= (more detail) 17 17535438 Homo sapiens
TAX023476
GO:0038061 biological process NIK/NF kappaB signaling The process in which a signal is passed on to downstream components within the cell through the NIK- (more detail) 17 NA Homo sapiens
TAX016568
GO:0006743 biological process ubiquinone metabolic process The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coen (more detail) 17 NA Homo sapiens
IEI008966
Protein protein interactors of human gene NOXA1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NOXA1 (SwissProt ID= (more detail) 17 17535438 Homo sapiens
IEI010346
Protein protein interactors of human gene PPP1R14A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PPP1R14A (SwissProt (more detail) 17 17535438 Homo sapiens
TAX030562
GO:0090545 cellular component CHD type complex A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) famil (more detail) 17 NA Homo sapiens
TAX019107
GO:0016581 cellular component NuRD complex An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activi (more detail) 17 NA Homo sapiens
IEI003569
Protein protein interactors of human gene DIS3L from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DIS3L (SwissProt ID= (more detail) 17 17535438 Homo sapiens
IEI011421
Protein protein interactors of human gene RNF19A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF19A (SwissProt ID (more detail) 17 17535438 Homo sapiens
WIG000059
ErbB receptor signaling network (more detail) 15 NA Homo sapiens
MOX001364
Genes associated with Computational Drug Signature CHLOROBENZENE Genes associated with Computational Drug Signature CHLOROBENZENE, curated by the Drug Signature Data (more detail) 15 25990557 Homo sapiens
MEX000144
Genes associated with Approved Drug furosemide Genes associated with Approved Drug furosemide, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
WIG001189
Genes involved in SHC1 events in EGFR signaling (more detail) 15 NA Homo sapiens
WAG000219
thrombin signaling and protease activated receptors Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation thr (more detail) 15 NA Homo sapiens
MOX006991
Genes associated with Computational Drug Signature amsacrine Genes associated with Computational Drug Signature amsacrine, curated by the Drug Signature Database (more detail) 15 25990557 Homo sapiens
MOX007135
Genes associated with Computational Drug Signature azathioprine Genes associated with Computational Drug Signature azathioprine, curated by the Drug Signature Datab (more detail) 15 25990557 Homo sapiens
WIG001131
Genes involved in Regulation of AMPK activity via LKB1 (more detail) 15 NA Homo sapiens
WIG001106
Genes involved in Processive synthesis on the lagging strand (more detail) 15 NA Homo sapiens
FOX000446
Genes in the cancer module 116 (more detail) 15 NA Homo sapiens
WIG000010
Arf6 downstream pathway (more detail) 15 NA Homo sapiens
MEX000481
Genes associated with Approved Drug erythromycin Genes associated with Approved Drug erythromycin, curated by the Drug Signature Database (DSigDB). (more detail) 15 25990557 Homo sapiens
WAG001552
Repair synthesis of patch ~27 30 bases long by DNA polymerase (more detail) 15 NA Homo sapiens
WIG000688
Genes involved in Amine derived hormones (more detail) 15 NA Homo sapiens
WAG000601
Parkinson's disease Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal n (more detail) 15 NA Homo sapiens
WIG000355
IL 3 signaling pathway Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding (more detail) 15 NA Homo sapiens
WAG000533
Repair synthesis for gap filling by DNA polymerase in TC NER (more detail) 15 NA Homo sapiens
IEI003117
Protein protein interactors of human gene CTLA4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CTLA4 (SwissProt ID= (more detail) 15 17535438 Homo sapiens
IEI013079
Protein protein interactors of human gene STAP2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene STAP2 (SwissProt ID= (more detail) 15 17535438 Homo sapiens
TAX032407
GO:1902187 biological process negative regulation of viral release from host cell Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host (more detail) 15 NA Homo sapiens
TAX023816
GO:0042403 biological process thyroid hormone metabolic process The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, la (more detail) 15 NA Homo sapiens
TAX019041
GO:0016471 cellular component vacuolar proton transporting V type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a p (more detail) 15 NA Homo sapiens
TAX033418
GO:1904380 biological process endoplasmic reticulum mannose trimming Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control (more detail) 15 NA Homo sapiens
IEI010237
Protein protein interactors of human gene POLR3G from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene POLR3G (SwissProt ID (more detail) 15 17535438 Homo sapiens
IEI011434
Protein protein interactors of human gene RNF25 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RNF25 (SwissProt ID= (more detail) 15 17535438 Homo sapiens
TAX030932
GO:0097617 molecular function annealing activity A nucleic acid binding activity that brings together complementary sequences of nucleic acids so tha (more detail) 13 NA Homo sapiens
IEI003377
Protein protein interactors of human gene DCUN1D2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DCUN1D2 (SwissProt I (more detail) 13 17535438 Homo sapiens
TAX017692
GO:0009437 biological process carnitine metabolic process The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a com (more detail) 13 NA Homo sapiens
TAX016120
GO:0006085 biological process acetyl CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzy (more detail) 13 NA Homo sapiens
TAX029635
GO:0071712 biological process ER associated misfolded protein catabolic process The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported fro (more detail) 13 NA Homo sapiens
TAX024005
GO:0042762 biological process regulation of sulfur metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways invo (more detail) 13 NA Homo sapiens
TAX028976
GO:0070525 biological process tRNA threonylcarbamoyladenosine metabolic process The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside (more detail) 13 NA Homo sapiens
TAX017631
GO:0009251 biological process glucan catabolic process The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consistin (more detail) 13 NA Homo sapiens
IEI014257
Protein protein interactors of human gene TRIM50 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM50 (SwissProt ID (more detail) 13 17535438 Homo sapiens
TAX033695
GO:1904923 biological process regulation of autophagy of mitochondrion in response to mitochondrial depolarization Any process that modulates the frequency, rate or extent of autophagy of mitochondrion in response t (more detail) 13 NA Homo sapiens
IEI014580
Protein protein interactors of human gene UBE2J2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene UBE2J2 (SwissProt ID (more detail) 13 17535438 Homo sapiens
IEI009745
Protein protein interactors of human gene PELI3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PELI3 (SwissProt ID= (more detail) 13 17535438 Homo sapiens
TAX023892
GO:0042554 biological process superoxide anion generation The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any c (more detail) 13 NA Homo sapiens
MEX001158
Genes associated with Approved Drug cephapirin sodium Genes associated with Approved Drug cephapirin sodium, curated by the Drug Signature Database (DSigD (more detail) 13 25990557 Homo sapiens
TAX001208
Genes annotated by the GO term GO:0004434. (more detail) 13 NA Homo sapiens
FEX002159
Lymphoma Lam01 23genes SuppTable 5. Proliferation genes (more detail) 13 11597333 Homo sapiens
MOX001847
Genes associated with Computational Drug Signature Ginkgolide B Genes associated with Computational Drug Signature Ginkgolide B, curated by the Drug Signature Datab (more detail) 13 25990557 Homo sapiens
MEX000430
Genes associated with Approved Drug pseudoephedrine Genes associated with Approved Drug pseudoephedrine, curated by the Drug Signature Database (DSigDB) (more detail) 13 25990557 Homo sapiens
MOX015935
Genes associated with Computational Drug Signature zaprinast Genes associated with Computational Drug Signature zaprinast, curated by the Drug Signature Database (more detail) 13 25990557 Homo sapiens
TAX001273
Genes annotated by the GO term GO:0019201. Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. (more detail) 13 NA Homo sapiens
MOX011994
Genes associated with Computational Drug Signature cisapride Genes associated with Computational Drug Signature cisapride, curated by the Drug Signature Database (more detail) 13 25990557 Homo sapiens
MOX001381
Genes associated with Computational Drug Signature 7 hydroxycoumarin Genes associated with Computational Drug Signature 7-hydroxycoumarin, curated by the Drug Signature (more detail) 13 25990557 Homo sapiens
MEX002309
Genes associated with Kinase Inhibitor Kinome 203 Genes associated with Kinase Inhibitor Kinome_203, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001547
Genes associated with Kinase Inhibitor 732983 37 8 Genes associated with Kinase Inhibitor 732983-37-8, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
TAX016359
GO:0006477 biological process protein sulfation The addition of a sulfate group as an ester to a protein amino acid. (more detail) 8 NA Homo sapiens
TAX024179
GO:0043139 molecular function 5' 3' DNA helicase activity Catalysis of the unwinding of the DNA helix in the direction 5' to 3'. (more detail) 8 NA Homo sapiens
TAX018861
GO:0016093 biological process polyprenol metabolic process The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid resid (more detail) 8 NA Homo sapiens
TAX014096
GO:0002161 molecular function aminoacyl tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA. (more detail) 8 NA Homo sapiens
PEX000706
PI3 PI4 kinase: Phosphatidylinositol 3 and 4 kinase Some members of this family probably do not have lipid kinase activity and are protein kinases, e.g. (more detail) 8 NA Homo sapiens
PEX001460
ADH zinc N 2: Zinc binding dehydrogenase (more detail) 8 NA Homo sapiens
PEX000780
2 Hacid dh C: D isomer specific 2 hydroxyacid dehydrogenase, NAD binding domain This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogena (more detail) 8 NA Homo sapiens
MOX011633
Genes associated with Computational Drug Signature CHEMBL608532 Genes associated with Computational Drug Signature CHEMBL608532, curated by the Drug Signature Datab (more detail) 8 25990557 Homo sapiens
TAX031502
GO:0102391 molecular function decanoate CoA ligase activity Catalysis of the reaction: decanoate + ATP(4-) + coenzyme A(4-) <=> decanoyl-CoA(4-) + AMP(2-) + dip (more detail) 8 NA Homo sapiens
TAX013211
GO:0000014 molecular function single stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecul (more detail) 8 NA Homo sapiens
WAG000513
Purine biosynthesis (more detail) 8 NA Homo sapiens
WIG000365
The Citric Acid Cycle The Krebs cycle, also called the citric acid cycle, is a fundamental metabolic pathway involving eig (more detail) 8 NA Homo sapiens
WIG002002
Mismatch repair Mismatch repair (more detail) 8 NA Homo sapiens
MEX001325
Genes associated with Kinase Inhibitor Kinome 463 Genes associated with Kinase Inhibitor Kinome_463, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001657
Genes associated with Kinase Inhibitor Kinome 3177 Genes associated with Kinase Inhibitor Kinome_3177, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001627
Genes associated with Kinase Inhibitor GW770249X Genes associated with Kinase Inhibitor GW770249X, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002351
Genes associated with Kinase Inhibitor 406209 26 5 Genes associated with Kinase Inhibitor 406209-26-5, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MOX003249
Genes associated with Computational Drug Signature 2 Propen 1 one, 3 (4 hydroxyphenyl) 1 phenyl Genes associated with Computational Drug Signature 2-Propen-1-one, 3-(4-hydroxyphenyl)-1-phenyl-, cu (more detail) 8 25990557 Homo sapiens
MOX006911
Genes associated with Computational Drug Signature ALOISINE A Genes associated with Computational Drug Signature ALOISINE A, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
TAX017555
GO:0009157 biological process deoxyribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphat (more detail) 8 NA Homo sapiens
TAX018788
GO:0015925 molecular function galactosidase activity Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cy (more detail) 8 NA Homo sapiens
TAX025980
GO:0047760 molecular function butyrate CoA ligase activity Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA. (more detail) 8 NA Homo sapiens
TAX027261
GO:0051920 molecular function peroxiredoxin activity Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. (more detail) 8 NA Homo sapiens
TAX019281
GO:0016885 molecular function ligase activity, forming carbon carbon bonds Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis (more detail) 8 NA Homo sapiens
TAX019307
GO:0016926 biological process protein desumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target pr (more detail) 8 NA Homo sapiens
TAX025613
GO:0046512 biological process sphingosine biosynthetic process The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), tran (more detail) 8 NA Homo sapiens
PEX000367
Abhydrolase 1: alpha/beta hydrolase fold This catalytic domain is found in a very wide range of enzymes. (more detail) 8 NA Homo sapiens
MOX015427
Genes associated with Computational Drug Signature Tarenflurbil Genes associated with Computational Drug Signature Tarenflurbil, curated by the Drug Signature Datab (more detail) 8 25990557 Homo sapiens
MOX015025
Genes associated with Computational Drug Signature SC 44463 Genes associated with Computational Drug Signature SC-44463, curated by the Drug Signature Database (more detail) 8 25990557 Homo sapiens
TAX001126
Genes annotated by the GO term GO:0009975. Catalysis of a ring closure reaction. (more detail) 8 NA Homo sapiens
WIG000639
Valine, leucine and isoleucine biosynthesis (more detail) 8 NA Homo sapiens
WIG001377
Caffeine Pathway, Pharmacokinetics Stylized liver cell showing candidate genes involved in the metabolism of caffeine. (more detail) 8 NA Homo sapiens
WIG001931
Glucocorticoid & Mineralcorticoid Metabolism Glucocorticoid & Mineralcorticoid Metabolism (more detail) 8 NA Homo sapiens
MEX001975
Genes associated with Kinase Inhibitor 1173900 33 8 Genes associated with Kinase Inhibitor 1173900-33-8, curated by the Drug Signature Database (DSigDB) (more detail) 8 25990557 Homo sapiens
MEX002140
Genes associated with Kinase Inhibitor Vatalanib Genes associated with Kinase Inhibitor Vatalanib, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MOX001992
Genes associated with Computational Drug Signature Hydroxychavicol Genes associated with Computational Drug Signature Hydroxychavicol, curated by the Drug Signature Da (more detail) 8 25990557 Homo sapiens
MOX012657
Genes associated with Computational Drug Signature Fasudil Genes associated with Computational Drug Signature Fasudil, curated by the Drug Signature Database ( (more detail) 8 25990557 Homo sapiens
TAX029096
GO:0070739 molecular function protein glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue (more detail) 8 NA Homo sapiens
TAX029097
GO:0070740 molecular function tubulin glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl (more detail) 8 NA Homo sapiens
TAX019019
GO:0016427 molecular function tRNA (cytosine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA contain (more detail) 8 NA Homo sapiens
TAX019189
GO:0016742 molecular function hydroxymethyl , formyl and related transferase activity Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another ( (more detail) 8 NA Homo sapiens
TAX018911
GO:0016208 molecular function AMP binding Interacting selectively and non-covalently with AMP, adenosine monophosphate. (more detail) 8 NA Homo sapiens
TAX019265
GO:0016861 molecular function intramolecular oxidoreductase activity, interconverting aldoses and ketoses Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which (more detail) 8 NA Homo sapiens
TAX027452
GO:0052805 biological process imidazole containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic (more detail) 8 NA Homo sapiens
TAX033407
GO:1904354 biological process negative regulation of telomere capping Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping. (more detail) 8 NA Homo sapiens
TAX016114
GO:0006072 biological process glycerol 3 phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycer (more detail) 8 NA Homo sapiens
TAX015232
GO:0004571 molecular function mannosyl oligosaccharide 1,2 alpha mannosidase activity Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-manno (more detail) 8 NA Homo sapiens
MOX009479
Genes associated with Computational Drug Signature CHEMBL292495 Genes associated with Computational Drug Signature CHEMBL292495, curated by the Drug Signature Datab (more detail) 8 25990557 Homo sapiens
TAX022977
GO:0035608 biological process protein deglutamylation The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encode (more detail) 8 NA Homo sapiens
TAX023318
GO:0036289 biological process peptidyl serine autophosphorylation The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine r (more detail) 8 NA Homo sapiens
TAX016415
GO:0006548 biological process histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol- (more detail) 8 NA Homo sapiens
TAX021562
GO:0032453 molecular function histone demethylase activity (H3 K4 specific) Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein. (more detail) 8 NA Homo sapiens
TAX021249
GO:0031956 molecular function medium chain fatty acid CoA ligase activity Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl- (more detail) 8 NA Homo sapiens
TAX020596
GO:0030638 biological process polyketide metabolic process The chemical reactions and pathways involving polyketides, any of a diverse group of natural product (more detail) 8 NA Homo sapiens
TAX026501
GO:0050665 biological process hydrogen peroxide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potent (more detail) 8 NA Homo sapiens
TAX027192
GO:0051791 biological process medium chain fatty acid metabolic process The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain (more detail) 8 NA Homo sapiens
TAX020829
GO:0031119 biological process tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. (more detail) 8 NA Homo sapiens
PEX002107
Peptidase C1: Papain family cysteine protease (more detail) 8 NA Homo sapiens
TAX031579
GO:0106074 biological process aminoacyl tRNA metabolism involved in translational fidelity Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or r (more detail) 8 NA Homo sapiens
WIG000201
Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. na (more detail) 8 NA Homo sapiens
WIG001338
Gefitinib Pathway, Pharmacokinetics Representation of the candidate genes involved in the transportation and metabolism of gefitinib. (more detail) 8 NA Homo sapiens
MEX001264
Genes associated with Kinase Inhibitor SB 747651A Genes associated with Kinase Inhibitor SB-747651A, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX000025
Genes associated with Approved Drug allopurinol Genes associated with Approved Drug allopurinol, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002242
Genes associated with Kinase Inhibitor Kinome 3566 Genes associated with Kinase Inhibitor Kinome_3566, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001462
Genes associated with Kinase Inhibitor SU9516 Genes associated with Kinase Inhibitor SU9516, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MOX000391
Genes associated with Computational Drug Signature 4 Nitrophenyl acetate Genes associated with Computational Drug Signature 4-Nitrophenyl acetate, curated by the Drug Signat (more detail) 8 25990557 Homo sapiens
TAX017198
GO:0008318 molecular function protein prenyltransferase activity Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group (more detail) 8 NA Homo sapiens
TAX022635
GO:0034720 biological process histone H3 K4 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the his (more detail) 8 NA Homo sapiens
TAX017136
GO:0008216 biological process spermidine metabolic process The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane. (more detail) 8 NA Homo sapiens
TAX017946
GO:0010510 biological process regulation of acetyl CoA biosynthetic process from pyruvate Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resu (more detail) 8 NA Homo sapiens
TAX024798
GO:0044598 biological process doxorubicin metabolic process The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in canc (more detail) 8 NA Homo sapiens
TAX021518
GO:0032404 molecular function mismatch repair complex binding Interacting selectively and non-covalently with a mismatch repair complex. (more detail) 8 NA Homo sapiens
TAX019172
GO:0016713 molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron sulfur protein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred (more detail) 8 NA Homo sapiens
TAX014761
GO:0003689 molecular function DNA clamp loader activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure o (more detail) 8 NA Homo sapiens
TAX033277
GO:1904047 molecular function S adenosyl L methionine binding Interacting selectively and non-covalently with S-adenosyl-L-methionine. (more detail) 8 NA Homo sapiens
WIG001791
Biosynthesis of Neurotransmitters Biosynthesis of Neurotransmitters (more detail) 8 NA Homo sapiens
MOX014959
Genes associated with Computational Drug Signature salicylic acid Genes associated with Computational Drug Signature salicylic acid, curated by the Drug Signature Dat (more detail) 8 25990557 Homo sapiens
WAG000205
D Arginine and D ornithine metabolism (more detail) 8 NA Homo sapiens
WAG000816
Atrazine degradation (more detail) 8 NA Homo sapiens
MAX001960
Genes involved in pyruvate metabolism; based on literature and sequence annotation resources and converted to Affymetrix HG U133A probe sets. DNA microarrays can be used to identify gene expression changes characteristic of human disease. Thi (more detail) 8 NA Homo sapiens
TAX001313
Genes annotated by the GO term GO:0016849. (more detail) 8 NA Homo sapiens
WIG001326
Warfarin Pathway, Pharmacokinetics Representation of the candidate genes involved in transport, metabolism and clearance of warfarin. (more detail) 8 NA Homo sapiens
MEX001406
Genes associated with Kinase Inhibitor CHEMBL1967720 Genes associated with Kinase Inhibitor CHEMBL1967720, curated by the Drug Signature Database (DSigDB (more detail) 8 25990557 Homo sapiens
MEX001586
Genes associated with Kinase Inhibitor Cdk4 Inhibitor Genes associated with Kinase Inhibitor Cdk4 Inhibitor, curated by the Drug Signature Database (DSigD (more detail) 8 25990557 Homo sapiens
MOX006316
Genes associated with Computational Drug Signature 693228 63 6 Genes associated with Computational Drug Signature 693228-63-6, curated by the Drug Signature Databa (more detail) 8 25990557 Homo sapiens
MOX003127
Genes associated with Computational Drug Signature 1,1' Biphenyl, 2,2',3,4',5',6 hexachloro Genes associated with Computational Drug Signature 1,1'-Biphenyl, 2,2',3,4',5',6-hexachloro-, curate (more detail) 8 25990557 Homo sapiens
MOX002683
Genes associated with Computational Drug Signature Ibrolipim Genes associated with Computational Drug Signature Ibrolipim, curated by the Drug Signature Database (more detail) 8 25990557 Homo sapiens
TAX029007
GO:0070567 molecular function cytidylyltransferase activity Catalysis of the transfer of a cytidylyl group to an acceptor. (more detail) 8 NA Homo sapiens
TAX029354
GO:0071265 biological process L methionine biosynthetic process The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (more detail) 8 NA Homo sapiens
TAX024797
GO:0044597 biological process daunorubicin metabolic process The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline (more detail) 8 NA Homo sapiens
TAX019422
GO:0017169 molecular function CDP alcohol phosphatidyltransferase activity Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. (more detail) 8 NA Homo sapiens
TAX019802
GO:0019773 cellular component proteasome core complex, alpha subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. (more detail) 8 NA Homo sapiens
TAX019129
GO:0016615 molecular function malate dehydrogenase activity Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. (more detail) 8 NA Homo sapiens
TAX019134
GO:0016624 molecular function oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts (more detail) 8 NA Homo sapiens
PEX000542
Acyl CoA dh N: Acyl CoA dehydrogenase, N terminal domain The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha domain. (more detail) 8 NA Homo sapiens
PEX002016
JmjN: jmjN domain (more detail) 8 NA Homo sapiens
MOX012534
Genes associated with Computational Drug Signature Entinostat Genes associated with Computational Drug Signature Entinostat, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
TAX013277
GO:0000150 molecular function recombinase activity Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA (more detail) 8 NA Homo sapiens
WAG000914
Phenylalanine and tyrosine catabolism (more detail) 8 NA Homo sapiens
MEX001319
Genes associated with Kinase Inhibitor CHEMBL592030 Genes associated with Kinase Inhibitor CHEMBL592030, curated by the Drug Signature Database (DSigDB) (more detail) 8 25990557 Homo sapiens
WAG001141
Transformation of lanosterol to cholesterol (more detail) 8 NA Homo sapiens
MEX000746
Genes associated with Approved Drug tadalafil Genes associated with Approved Drug tadalafil, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002316
Genes associated with Kinase Inhibitor GW693917A Genes associated with Kinase Inhibitor GW693917A, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001661
Genes associated with Kinase Inhibitor CGP 57380 Genes associated with Kinase Inhibitor CGP 57380, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001480
Genes associated with Kinase Inhibitor Src Kinase Inhibitor I Genes associated with Kinase Inhibitor Src Kinase Inhibitor I, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
MEX001489
Genes associated with Kinase Inhibitor Kinome 458 Genes associated with Kinase Inhibitor Kinome_458, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MOX004874
Genes associated with Computational Drug Signature 3,4 Dihydroxyphenylacetic acid Genes associated with Computational Drug Signature 3,4-Dihydroxyphenylacetic acid, curated by the Dr (more detail) 8 25990557 Homo sapiens
TAX022015
GO:0033170 molecular function protein DNA loading ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the assembly of a protein or protei (more detail) 8 NA Homo sapiens
TAX016394
GO:0006527 biological process arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidami (more detail) 8 NA Homo sapiens
TAX016709
GO:0006975 biological process DNA damage induced protein phosphorylation The widespread phosphorylation of various molecules, triggering many downstream processes, that occu (more detail) 8 NA Homo sapiens
TAX017596
GO:0009204 biological process deoxyribonucleoside triphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate (more detail) 8 NA Homo sapiens
TAX025035
GO:0045254 cellular component pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises sub (more detail) 8 NA Homo sapiens
TAX019007
GO:0016413 molecular function O acetyltransferase activity Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. (more detail) 8 NA Homo sapiens
TAX024890
GO:0045008 biological process depyrimidination The disruption of the bond between the sugar in the backbone and the C or T base, causing the base t (more detail) 8 NA Homo sapiens
TAX025809
GO:0046920 molecular function alpha (1 >3) fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to fo (more detail) 8 NA Homo sapiens
TAX014802
GO:0003831 molecular function beta N acetylglucosaminylglycopeptide beta 1,4 galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-g (more detail) 8 NA Homo sapiens
TAX015039
GO:0004300 molecular function enoyl CoA hydratase activity Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. (more detail) 8 NA Homo sapiens
TAX016073
GO:0006013 biological process mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer o (more detail) 8 NA Homo sapiens
TAX015132
GO:0004439 molecular function phosphatidylinositol 4,5 bisphosphate 5 phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- (more detail) 8 NA Homo sapiens
TAX015546
GO:0005005 molecular function transmembrane ephrin receptor activity Combining with a transmembrane ephrin to initiate a change in cell activity. (more detail) 8 NA Homo sapiens
PEX000430
Acyl CoA dh 1: Acyl CoA dehydrogenase, C terminal domain C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle. (more detail) 8 NA Homo sapiens
PEX002015
Ephrin lbd: Ephrin receptor ligand binding domain The Eph receptors, which bind to ephrins Pfam:PF00812 are a large family of receptor tyrosine kinase (more detail) 8 NA Homo sapiens
MOX012672
Genes associated with Computational Drug Signature ferulic acid Genes associated with Computational Drug Signature ferulic acid, curated by the Drug Signature Datab (more detail) 8 25990557 Homo sapiens
MOX014659
Genes associated with Computational Drug Signature Psoralen Genes associated with Computational Drug Signature Psoralen, curated by the Drug Signature Database (more detail) 8 25990557 Homo sapiens
MEX001920
Genes associated with Kinase Inhibitor GW784307A Genes associated with Kinase Inhibitor GW784307A, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002272
Genes associated with Kinase Inhibitor Kinome 876 Genes associated with Kinase Inhibitor Kinome_876, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX002300
Genes associated with Kinase Inhibitor GSK619487A Genes associated with Kinase Inhibitor GSK619487A, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001470
Genes associated with Kinase Inhibitor Kinome 258 Genes associated with Kinase Inhibitor Kinome_258, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MOX004918
Genes associated with Computational Drug Signature fluconazole Genes associated with Computational Drug Signature fluconazole, curated by the Drug Signature Databa (more detail) 8 25990557 Homo sapiens
MOX004579
Genes associated with Computational Drug Signature Prodigiosin Genes associated with Computational Drug Signature Prodigiosin, curated by the Drug Signature Databa (more detail) 8 25990557 Homo sapiens
MOX011985
Genes associated with Computational Drug Signature ciprofloxacin Genes associated with Computational Drug Signature ciprofloxacin, curated by the Drug Signature Data (more detail) 8 25990557 Homo sapiens
TAX023290
GO:0036155 biological process acylglycerol acyl chain remodeling Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation react (more detail) 8 NA Homo sapiens
TAX017290
GO:0008469 molecular function histone arginine N methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine (more detail) 8 NA Homo sapiens
TAX022518
GO:0034475 biological process U4 snRNA 3' end processing Any process involved in forming the mature 3' end of a U4 snRNA molecule. (more detail) 8 NA Homo sapiens
TAX016592
GO:0006782 biological process protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. (more detail) 8 NA Homo sapiens
TAX030195
GO:0085020 biological process protein K6 linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine (more detail) 8 NA Homo sapiens
TAX018887
GO:0016139 biological process glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a g (more detail) 8 NA Homo sapiens
TAX026111
GO:0048256 molecular function flap endonuclease activity Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the en (more detail) 8 NA Homo sapiens
TAX016137
GO:0006108 biological process malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral (more detail) 8 NA Homo sapiens
TAX014903
GO:0003996 molecular function acyl CoA ligase activity Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-Co (more detail) 8 NA Homo sapiens
PEX001793
Acyl CoA dh M: Acyl CoA dehydrogenase, middle domain Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold. (more detail) 8 NA Homo sapiens
PEX001107
Acetyltransf 1: Acetyltransferase (GNAT) family This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins. (more detail) 8 NA Homo sapiens
WIG001815
Catabolic Pathway for Arginine,Histidine,Glutamate,Glutamine and Proline Catabolic Pathway for Arginine,Histidine,Glutamate,Glutamine and Proline (more detail) 8 NA Homo sapiens
MOX015639
Genes associated with Computational Drug Signature Triphenylacrylonitrile Genes associated with Computational Drug Signature Triphenylacrylonitrile, curated by the Drug Signa (more detail) 8 25990557 Homo sapiens
MOX014153
Genes associated with Computational Drug Signature NSC160436 Genes associated with Computational Drug Signature NSC160436, curated by the Drug Signature Database (more detail) 8 25990557 Homo sapiens
MOX014852
Genes associated with Computational Drug Signature ro 32 0432 Genes associated with Computational Drug Signature ro 32-0432, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
TAX023716
GO:0042182 biological process ketone catabolic process The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compou (more detail) 8 NA Homo sapiens
WIG002029
Aflatoxin B1 metabolism Aflatoxin B1 metabolism (more detail) 8 NA Homo sapiens
MEX001241
Genes associated with Kinase Inhibitor Kinome 77 Genes associated with Kinase Inhibitor Kinome_77, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MEX001338
Genes associated with Kinase Inhibitor 5Z 7 Oxozeaenol Genes associated with Kinase Inhibitor 5Z-7-Oxozeaenol, curated by the Drug Signature Database (DSig (more detail) 8 25990557 Homo sapiens
MEX001541
Genes associated with Kinase Inhibitor Bay 65 1942 hydrochloride Genes associated with Kinase Inhibitor Bay 65-1942 hydrochloride, curated by the Drug Signature Data (more detail) 8 25990557 Homo sapiens
MEX002257
Genes associated with Kinase Inhibitor 4 anilinopyrimidine 8c Genes associated with Kinase Inhibitor 4-anilinopyrimidine 8c, curated by the Drug Signature Databas (more detail) 8 25990557 Homo sapiens
MEX001609
Genes associated with Kinase Inhibitor 2zv2 Genes associated with Kinase Inhibitor 2zv2, curated by the Drug Signature Database (DSigDB). (more detail) 8 25990557 Homo sapiens
MOX001093
Genes associated with Computational Drug Signature SODIUM HYDROSULFIDE Genes associated with Computational Drug Signature SODIUM HYDROSULFIDE, curated by the Drug Signatur (more detail) 8 25990557 Homo sapiens
MOX000545
Genes associated with Computational Drug Signature 4 Hydroperoxycyclofosfamide Genes associated with Computational Drug Signature 4-Hydroperoxycyclofosfamide, curated by the Drug (more detail) 16 25990557 Homo sapiens
GEX001179
neural tube defects neural tube defects associated genes. PAGER constructed this gene set by grouping all genes which ar (more detail) 16 NA Homo sapiens
MOX005111
Genes associated with Computational Drug Signature cisapride Genes associated with Computational Drug Signature cisapride, curated by the Drug Signature Database (more detail) 16 25990557 Homo sapiens
MEX000118
Genes associated with Approved Drug ethoxzolamide Genes associated with Approved Drug ethoxzolamide, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
MAX003219
Down regulated genes distinguishing hepatocellular carcinoma (HCC) samples positive for EPCAM [GeneID=4072] from the negative ones. The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers ha (more detail) 16 NA Homo sapiens
WAG001484
EPHA2 forward signaling (more detail) 16 NA Homo sapiens
MOX004474
Genes associated with Computational Drug Signature papaverine Genes associated with Computational Drug Signature papaverine, curated by the Drug Signature Databas (more detail) 16 25990557 Homo sapiens
MOX006275
Genes associated with Computational Drug Signature 6 bromo N (3 chlorophenyl)quinazolin 4 amine Genes associated with Computational Drug Signature 6-bromo-N-(3-chlorophenyl)quinazolin-4-amine, cur (more detail) 16 25990557 Homo sapiens
FEX001580
Leukemia Sanchez Guijo08 17genes Supplementary Table 2f. Genes differentially expressed in Group A and Group B chronic myeloid leukae (more detail) 16 18722011 Homo sapiens
MOX017210
Genes associated with Computational Drug Signature DEHYDROASCORBIC ACID Genes associated with Computational Drug Signature DEHYDROASCORBIC ACID, curated by the Drug Signatu (more detail) 16 25990557 Homo sapiens
TAX013293
GO:0000176 cellular component nuclear exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuc (more detail) 16 NA Homo sapiens
MEX000042
Genes associated with Approved Drug azathioprine Genes associated with Approved Drug azathioprine, curated by the Drug Signature Database (DSigDB). (more detail) 16 25990557 Homo sapiens
WAG000423
human cytomegalovirus and map kinase pathways To replicate in the host cell, viruses commandeer cellular sigling pathways. Cytomegalovirus (CMV) i (more detail) 16 NA Homo sapiens
TAX013457
GO:0000712 biological process resolution of meiotic recombination intermediates The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recom (more detail) 16 NA Homo sapiens
MOX005520
Genes associated with Computational Drug Signature 172889 27 9 Genes associated with Computational Drug Signature 172889-27-9, curated by the Drug Signature Databa (more detail) 16 25990557 Homo sapiens
FEX001032
Esophagus Fukuda04 19genes Table 3. Upregulated genes in radioresistant sublines in comparison to parent cell lines (more detail) 16 15365572 Homo sapiens
TAX000332
Genes annotated by the GO term GO:0007131. The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. (more detail) 16 NA Homo sapiens
MOX001203
Genes associated with Computational Drug Signature AFLATOXIN G1 Genes associated with Computational Drug Signature AFLATOXIN G1, curated by the Drug Signature Datab (more detail) 16 25990557 Homo sapiens
MOX002190
Genes associated with Computational Drug Signature Isoorientin Genes associated with Computational Drug Signature Isoorientin, curated by the Drug Signature Databa (more detail) 16 25990557 Homo sapiens
WAG000900
Gluconeogenesis (more detail) 16 NA Homo sapiens
TAX022514
GO:0034471 biological process ncRNA 5' end processing Any process involved in forming the mature 5' end of a non-coding RNA molecule. (more detail) 16 NA Homo sapiens
IEI012036
Protein protein interactors of human gene SERPINB4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SERPINB4 (SwissProt (more detail) 16 17535438 Homo sapiens
IEI009853
Protein protein interactors of human gene PHF7 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PHF7 (SwissProt ID=Q (more detail) 16 17535438 Homo sapiens
IEI003055
Protein protein interactors of human gene CSN1S1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CSN1S1 (SwissProt ID (more detail) 16 17535438 Homo sapiens
TAX017849
GO:0010042 biological process response to manganese ion Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 16 NA Homo sapiens
IEI011497
Protein protein interactors of human gene RPH3A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RPH3A (SwissProt ID= (more detail) 16 17535438 Homo sapiens
TAX032219
GO:1901663 biological process quinone biosynthetic process The chemical reactions and pathways resulting in the formation of quinone. (more detail) 16 NA Homo sapiens
TAX016569
GO:0006744 biological process ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electr (more detail) 16 NA Homo sapiens
IEI002204
Protein protein interactors of human gene CDCA4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CDCA4 (SwissProt ID= (more detail) 16 17535438 Homo sapiens
TAX022007
GO:0033158 biological process regulation of protein import into nucleus, translocation Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, (more detail) 16 NA Homo sapiens
MOX003945
Genes associated with Computational Drug Signature dextromethorphan Genes associated with Computational Drug Signature dextromethorphan, curated by the Drug Signature D (more detail) 10 25990557 Homo sapiens
MEX000534
Genes associated with Approved Drug deslanoside Genes associated with Approved Drug deslanoside, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MEX000417
Genes associated with Approved Drug isopropamide iodide Genes associated with Approved Drug isopropamide iodide, curated by the Drug Signature Database (DSi (more detail) 10 25990557 Homo sapiens
WIG001404
Nicotine Pathway, Pharmacokinetics Summary of nicotine metabolism in human liver cell. (more detail) 10 NA Homo sapiens
WIG001362
Fluoropyrimidine Pathway, Pharmacodynamics Model non-tissue-specific cancer cell displaying genes which may be involved in the pharmacodynamics (more detail) 10 NA Homo sapiens
WIG001122
Genes involved in RAF/MAP kinase cascade (more detail) 10 NA Homo sapiens
TAX001200
Genes annotated by the GO term GO:0016799. Catalysis of the hydrolysis of any N glycosyl bond. (more detail) 10 NA Homo sapiens
MOX004370
Genes associated with Computational Drug Signature minoxidil Genes associated with Computational Drug Signature minoxidil, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
WIG001991
Steroid Biosynthesis Steroid Biosynthesis (more detail) 10 NA Homo sapiens
MOX013102
Genes associated with Computational Drug Signature IK 682 Genes associated with Computational Drug Signature IK-682, curated by the Drug Signature Database (D (more detail) 10 25990557 Homo sapiens
MOX006342
Genes associated with Computational Drug Signature 7 hydroxy 3 phenyl 2H chromen 2 one Genes associated with Computational Drug Signature 7-hydroxy-3-phenyl-2H-chromen-2-one, curated by t (more detail) 10 25990557 Homo sapiens
MOX001445
Genes associated with Computational Drug Signature 1 aminobenzotriazole Genes associated with Computational Drug Signature 1-aminobenzotriazole, curated by the Drug Signatu (more detail) 10 25990557 Homo sapiens
MOX013460
Genes associated with Computational Drug Signature Linifanib Genes associated with Computational Drug Signature Linifanib, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
TAX000574
Genes annotated by the GO term GO:0006163. The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5' hydroxyl group of its glycose moiety. (more detail) 10 NA Homo sapiens
TAX001394
Genes annotated by the GO term GO:0033764. Catalysis of an oxidation reduction (redox) reaction in which a CH OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. (more detail) 10 NA Homo sapiens
WIG001142
Genes involved in Regulation of Insulin Secretion by Acetylcholine (more detail) 10 NA Homo sapiens
MOX007171
Genes associated with Computational Drug Signature balanol Genes associated with Computational Drug Signature balanol, curated by the Drug Signature Database ( (more detail) 10 25990557 Homo sapiens
MOX013985
Genes associated with Computational Drug Signature naringenin Genes associated with Computational Drug Signature naringenin, curated by the Drug Signature Databas (more detail) 10 25990557 Homo sapiens
MOX016433
Genes associated with Computational Drug Signature Nafamostat Genes associated with Computational Drug Signature Nafamostat, curated by the Drug Signature Databas (more detail) 10 25990557 Homo sapiens
MOX017025
Genes associated with Computational Drug Signature GUANOSINE TRIPHOSPHATE Genes associated with Computational Drug Signature GUANOSINE TRIPHOSPHATE, curated by the Drug Signa (more detail) 10 25990557 Homo sapiens
PEX001072
FKBP C: FKBP type peptidyl prolyl cis trans isomerase (more detail) 10 NA Homo sapiens
MOX015964
Genes associated with Computational Drug Signature ZM 336372 Genes associated with Computational Drug Signature ZM 336372, curated by the Drug Signature Database (more detail) 10 25990557 Homo sapiens
TAX000231
Genes annotated by the GO term GO:0006073. The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. (more detail) 10 NA Homo sapiens
WIG001254
Genes involved in Synthesis of PIPs at the late endosome membrane (more detail) 10 NA Homo sapiens
TAX000998
Genes annotated by the GO term GO:0008250. A multisubunit protein complex in the endoplasmic reticulum membrane of eukaryotes that transfers lipid linked oligosaccharide precursor to asparagine residues on nascent proteins; includes at least nine different subunits, at least in yeast. (more detail) 10 NA Homo sapiens
MOX003351
Genes associated with Computational Drug Signature 6,7 dihydroxyflavone Genes associated with Computational Drug Signature 6,7-dihydroxyflavone, curated by the Drug Signatu (more detail) 10 25990557 Homo sapiens
TAX000002
Genes annotated by the GO term GO:0030048. Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. (more detail) 10 NA Homo sapiens
MAX002889
Protein kinase genes most significantly up regulated in ASPS (alveolar soft part sarcoma) tumors compared to four other types of primitive sarcomas. Specific chromosomal translocations encoding chimeric transcription factors are considered to play c (more detail) 10 NA Homo sapiens
MOX001574
Genes associated with Computational Drug Signature 3,3',4,4' Tetrabromobiphenyl Genes associated with Computational Drug Signature 3,3',4,4'-Tetrabromobiphenyl, curated by the Drug (more detail) 10 25990557 Homo sapiens
MOX000174
Genes associated with Computational Drug Signature Harman Genes associated with Computational Drug Signature Harman, curated by the Drug Signature Database (D (more detail) 10 25990557 Homo sapiens
WIG000862
Genes involved in Gamma carboxylation, transport, and amino terminal cleavage of proteins (more detail) 10 NA Homo sapiens
WIG000721
Genes involved in Base free sugar phosphate removal via the single nucleotide replacement pathway (more detail) 10 NA Homo sapiens
MEX000550
Genes associated with Approved Drug carbidopa Genes associated with Approved Drug carbidopa, curated by the Drug Signature Database (DSigDB). (more detail) 10 25990557 Homo sapiens
MOX005135
Genes associated with Computational Drug Signature DEXMEDETOMIDINE Genes associated with Computational Drug Signature DEXMEDETOMIDINE, curated by the Drug Signature Da (more detail) 10 25990557 Homo sapiens
TAX013894
GO:0001867 biological process complement activation, lectin pathway Any process involved in the activation of any of the steps of the lectin pathway of the complement c (more detail) 10 NA Homo sapiens
WIG000951
Genes involved in IRAK1 recruits IKK complex (more detail) 10 NA Homo sapiens
MOX001433
Genes associated with Computational Drug Signature 3,3',4,4',5,5' Hexabromobiphenyl Genes associated with Computational Drug Signature 3,3',4,4',5,5'-Hexabromobiphenyl, curated by the (more detail) 10 25990557 Homo sapiens
MOX003729
Genes associated with Computational Drug Signature Benzofurans Genes associated with Computational Drug Signature Benzofurans, curated by the Drug Signature Databa (more detail) 10 25990557 Homo sapiens
TAX030593
GO:0090657 biological process telomeric loop disassembly The telomere maintenance process in which telomeric loops are disassembled to permit efficient telom (more detail) 10 NA Homo sapiens
TAX020412
GO:0030259 biological process lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. (more detail) 10 NA Homo sapiens
TAX022681
GO:0034982 biological process mitochondrial protein processing The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. (more detail) 10 NA Homo sapiens
TAX025548
GO:0046385 biological process deoxyribose phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phospho (more detail) 10 NA Homo sapiens
TAX027064
GO:0051567 biological process histone H3 K9 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of t (more detail) 10 NA Homo sapiens
IEI007758
Protein protein interactors of human gene MBD3L1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MBD3L1 (SwissProt ID (more detail) 10 17535438 Homo sapiens
TAX020976
GO:0031414 cellular component N terminal protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acce (more detail) 10 NA Homo sapiens
TAX019681
GO:0019336 biological process phenol containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing (more detail) 10 NA Homo sapiens
TAX017642
GO:0009265 biological process 2' deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compou (more detail) 10 NA Homo sapiens
IEI015829
Protein protein interactors of human gene ZNRF4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ZNRF4 (SwissProt ID= (more detail) 10 17535438 Homo sapiens
TAX016421
GO:0006554 biological process lysine catabolic process The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. (more detail) 10 NA Homo sapiens
TAX021476
GO:0032356 molecular function oxidized DNA binding Interacting selectively and non-covalently with oxidized residues in DNA. (more detail) 10 NA Homo sapiens
WEX000042
IDH1/2 The genes related to idh1/2 (metabolism) in tumor, immune using next-generation sequencer (NGS) read (more detail) 10 NA Homo sapiens
TAX016343
GO:0006450 biological process regulation of translational fidelity Any process that modulates the ability of the translational apparatus to interpret the genetic code. (more detail) 14 NA Homo sapiens
IEI008654
Protein protein interactors of human gene NDFIP2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NDFIP2 (SwissProt ID (more detail) 14 17535438 Homo sapiens
IEI000951
Protein protein interactors of human gene ASB11 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ASB11 (SwissProt ID= (more detail) 14 17535438 Homo sapiens
IEI013376
Protein protein interactors of human gene TAOK2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TAOK2 (SwissProt ID= (more detail) 14 17535438 Homo sapiens
IEI004219
Protein protein interactors of human gene EPM2A from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EPM2A (SwissProt ID= (more detail) 14 17535438 Homo sapiens
IEI005910
Protein protein interactors of human gene HMGN2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene HMGN2 (SwissProt ID= (more detail) 14 17535438 Homo sapiens
IEI012133
Protein protein interactors of human gene SH2B1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SH2B1 (SwissProt ID= (more detail) 14 17535438 Homo sapiens
TAX023845
GO:0042447 biological process hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring s (more detail) 14 NA Homo sapiens
IEI015022
Protein protein interactors of human gene WDR74 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene WDR74 (SwissProt ID= (more detail) 14 17535438 Homo sapiens
MOX000540
Genes associated with Computational Drug Signature zaprinast Genes associated with Computational Drug Signature zaprinast, curated by the Drug Signature Database (more detail) 14 25990557 Homo sapiens
FEX000726
Breast Lin09 15genes 2. ER-associated degradation (ERAD) Pathway (more detail) 14 19695104 Homo sapiens
FEX001363
Leukemia Bal05 15genes Table 6 Deregulation of DNA repair proteins in acutely HTLV-1 transformed cells (more detail) 14 15896717 Homo sapiens
FEX002644
Prostate Hendriksen06 15genes Table S3b. AR pathway genes differentially expressed between normal prostate low- and highgrade PC (more detail) 14 16707422 Homo sapiens
WIG001444
Checkpoint Comparative Pathways Checkpoint Comparative Pathways (more detail) 14 NA Homo sapiens
MOX003993
Genes associated with Computational Drug Signature Succimer Genes associated with Computational Drug Signature Succimer, curated by the Drug Signature Database (more detail) 14 25990557 Homo sapiens
MOX003446
Genes associated with Computational Drug Signature 3',4' Dimethoxyflavone Genes associated with Computational Drug Signature 3',4'-Dimethoxyflavone, curated by the Drug Signa (more detail) 14 25990557 Homo sapiens
MEX000897
Genes associated with Approved Drug sulindac Genes associated with Approved Drug sulindac, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MOX014351
Genes associated with Computational Drug Signature papaverine Genes associated with Computational Drug Signature papaverine, curated by the Drug Signature Databas (more detail) 14 25990557 Homo sapiens
MOX014037
Genes associated with Computational Drug Signature nimesulide Genes associated with Computational Drug Signature nimesulide, curated by the Drug Signature Databas (more detail) 14 25990557 Homo sapiens
WIG001155
Genes involved in Repair synthesis for gap filling by DNA polymerase in TC NER (more detail) 14 NA Homo sapiens
WAG001365
Removal of the Flap Intermediate (more detail) 14 NA Homo sapiens
MOX004084
Genes associated with Computational Drug Signature 4602 84 0 Genes associated with Computational Drug Signature 4602-84-0, curated by the Drug Signature Database (more detail) 14 25990557 Homo sapiens
MEX000200
Genes associated with Approved Drug mefenamic acid Genes associated with Approved Drug mefenamic acid, curated by the Drug Signature Database (DSigDB). (more detail) 14 25990557 Homo sapiens
MOX003221
Genes associated with Computational Drug Signature 7 Hydroxyflavone Genes associated with Computational Drug Signature 7-Hydroxyflavone, curated by the Drug Signature D (more detail) 14 25990557 Homo sapiens
MOX003817
Genes associated with Computational Drug Signature cephalothin Genes associated with Computational Drug Signature cephalothin, curated by the Drug Signature Databa (more detail) 14 25990557 Homo sapiens
WIG001322
Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics Drug-specific representation of the candidate genes involved in transport, metabolism and clearance. (more detail) 14 NA Homo sapiens
TAX019454
GO:0018065 biological process protein cofactor linkage The covalent attachment of a cofactor to a protein. (more detail) 12 NA Homo sapiens
TAX028832
GO:0070262 biological process peptidyl serine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine. (more detail) 12 NA Homo sapiens
TAX015905
GO:0005750 cellular component mitochondrial respiratory chain complex III A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial r (more detail) 12 NA Homo sapiens
IEI001304
Protein protein interactors of human gene BDKRB2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene BDKRB2 (SwissProt ID (more detail) 12 17535438 Homo sapiens
IEI008415
Protein protein interactors of human gene MYBPC3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MYBPC3 (SwissProt ID (more detail) 12 17535438 Homo sapiens
IEI003378
Protein protein interactors of human gene DCUN1D3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DCUN1D3 (SwissProt I (more detail) 12 17535438 Homo sapiens
IEI012174
Protein protein interactors of human gene SHC2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene SHC2 (SwissProt ID=P (more detail) 12 17535438 Homo sapiens
TAX027451
GO:0052803 biological process imidazole containing compound metabolic process The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containi (more detail) 12 NA Homo sapiens
TAX016049
GO:0005980 biological process glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly b (more detail) 12 NA Homo sapiens
TAX022860
GO:0035404 biological process histone serine phosphorylation The modification of histones by addition of a phosphate group to a serine residue. (more detail) 12 NA Homo sapiens
TAX024184
GO:0043144 biological process snoRNA processing Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a m (more detail) 12 NA Homo sapiens
TAX019493
GO:0018206 biological process peptidyl methionine modification The modification of peptidyl-methionine. (more detail) 12 NA Homo sapiens
TAX026800
GO:0051103 biological process DNA ligation involved in DNA repair The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, tha (more detail) 12 NA Homo sapiens
TAX022674
GO:0034969 biological process histone arginine methylation The modification of a histone by addition of a methyl group to an arginine residue. (more detail) 12 NA Homo sapiens
TAX025045
GO:0045275 cellular component respiratory chain complex III A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two proto (more detail) 12 NA Homo sapiens
TAX033697
GO:1904925 biological process positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization Any process that activates or increases the frequency, rate or extent of autophagy of the mitochondr (more detail) 12 NA Homo sapiens
TAX016167
GO:0006171 biological process cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, a (more detail) 12 NA Homo sapiens
TAX015866
GO:0005675 cellular component holo TFIIH complex A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the lar (more detail) 12 NA Homo sapiens
MOX014228
Genes associated with Computational Drug Signature ofloxacin Genes associated with Computational Drug Signature ofloxacin, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
MOX005179
Genes associated with Computational Drug Signature ( ) Epicatechin Genes associated with Computational Drug Signature (-)-Epicatechin, curated by the Drug Signature Da (more detail) 12 25990557 Homo sapiens
PEX002387
FGF: Fibroblast growth factor Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide (more detail) 12 NA Homo sapiens
MAX002077
Genes down regulated in acute myeloid leukemia (AML) samples with constitutively activated FLT3 [GeneID=2322] or with activating point mutations within NRAS [GeneID=4893] . In acute myeloid leukemia (AML), constitutive activation of the FLT3 receptor tyrosine kinase, eithe (more detail) 12 NA Homo sapiens
MOX002260
Genes associated with Computational Drug Signature 5,7 Dimethoxyflavone Genes associated with Computational Drug Signature 5,7-Dimethoxyflavone, curated by the Drug Signatu (more detail) 12 25990557 Homo sapiens
TAX000297
Genes annotated by the GO term GO:0006720. The chemical reactions and pathways involving isoprenoid compounds, isoprene (2 methylbuta 1,3 diene) or compounds containing or derived from linked isoprene (3 methyl 2 butenylene) residues. (more detail) 12 NA Homo sapiens
MOX015616
Genes associated with Computational Drug Signature trichostatin A Genes associated with Computational Drug Signature trichostatin A, curated by the Drug Signature Dat (more detail) 12 25990557 Homo sapiens
MOX017808
Genes associated with Computational Drug Signature 2,6 Di tert butyl 4 methylphenol Genes associated with Computational Drug Signature 2,6-Di-tert-butyl-4-methylphenol, curated by the (more detail) 12 25990557 Homo sapiens
TAX000803
Genes annotated by the GO term GO:0006399. The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. (more detail) 12 NA Homo sapiens
MOX000604
Genes associated with Computational Drug Signature quercitrin Genes associated with Computational Drug Signature quercitrin, curated by the Drug Signature Databas (more detail) 12 25990557 Homo sapiens
MOX013103
Genes associated with Computational Drug Signature Ilomastat Genes associated with Computational Drug Signature Ilomastat, curated by the Drug Signature Database (more detail) 12 25990557 Homo sapiens
MOX017383
Genes associated with Computational Drug Signature sodium azide Genes associated with Computational Drug Signature sodium azide, curated by the Drug Signature Datab (more detail) 12 25990557 Homo sapiens
MOX004165
Genes associated with Computational Drug Signature cyclic gmp Genes associated with Computational Drug Signature cyclic gmp, curated by the Drug Signature Databas (more detail) 12 25990557 Homo sapiens
TAX013463
GO:0000722 biological process telomere maintenance via recombination Any recombinational process that contributes to the maintenance of proper telomeric length. (more detail) 12 NA Homo sapiens
MEX001916
Genes associated with Kinase Inhibitor (E) N Methyl 2 ((3 (2 (pyridin 2 yl)vinyl) 1H indazol 6 yl)thio)benzamide Genes associated with Kinase Inhibitor (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)th (more detail) 7 25990557 Homo sapiens
MOX013193
Genes associated with Computational Drug Signature isogranulatimide Genes associated with Computational Drug Signature isogranulatimide, curated by the Drug Signature D (more detail) 7 25990557 Homo sapiens
MOX011750
Genes associated with Computational Drug Signature CHEMBL76100 Genes associated with Computational Drug Signature CHEMBL76100, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX014635
Genes associated with Computational Drug Signature propylthiouracil Genes associated with Computational Drug Signature propylthiouracil, curated by the Drug Signature D (more detail) 7 25990557 Homo sapiens
WAG001228
Methane metabolism (more detail) 7 NA Homo sapiens
WAG001292
Cholesterol biosynthesis (more detail) 7 NA Homo sapiens
WAG001349
Pentose phosphate pathway (hexose monophosphate shunt) (more detail) 7 NA Homo sapiens
MEX002258
Genes associated with Kinase Inhibitor GW795486X Genes associated with Kinase Inhibitor GW795486X, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001614
Genes associated with Kinase Inhibitor Kinome 245 Genes associated with Kinase Inhibitor Kinome_245, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002282
Genes associated with Kinase Inhibitor Akt inhibitor VIII Genes associated with Kinase Inhibitor Akt inhibitor VIII, curated by the Drug Signature Database (D (more detail) 7 25990557 Homo sapiens
MEX001845
Genes associated with Kinase Inhibitor Lapatinib Genes associated with Kinase Inhibitor Lapatinib, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX000162
Genes associated with Approved Drug hydroxyurea Genes associated with Approved Drug hydroxyurea, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX001579
Genes associated with Computational Drug Signature MeIQ Genes associated with Computational Drug Signature MeIQ, curated by the Drug Signature Database (DSi (more detail) 7 25990557 Homo sapiens
MOX000842
Genes associated with Computational Drug Signature Mea alpha C Genes associated with Computational Drug Signature Mea-alpha-C, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX004765
Genes associated with Computational Drug Signature Ticrynafen Genes associated with Computational Drug Signature Ticrynafen, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
MOX005106
Genes associated with Computational Drug Signature Delavirdine Genes associated with Computational Drug Signature Delavirdine, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX013239
Genes associated with Computational Drug Signature JNJ 10198409 Genes associated with Computational Drug Signature JNJ-10198409, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
MOX012970
Genes associated with Computational Drug Signature gw8510 Genes associated with Computational Drug Signature gw8510, curated by the Drug Signature Database (D (more detail) 7 25990557 Homo sapiens
MOX011430
Genes associated with Computational Drug Signature CHEMBL574589 Genes associated with Computational Drug Signature CHEMBL574589, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
MEX001607
Genes associated with Kinase Inhibitor Kinome 41 Genes associated with Kinase Inhibitor Kinome_41, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001611
Genes associated with Kinase Inhibitor Kinome 125 Genes associated with Kinase Inhibitor Kinome_125, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002291
Genes associated with Kinase Inhibitor CHEMBL188268 Genes associated with Kinase Inhibitor CHEMBL188268, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MEX001494
Genes associated with Kinase Inhibitor EGFR/ErbB 2/ErbB 4 Inhibitor Genes associated with Kinase Inhibitor EGFR/ErbB-2/ErbB-4 Inhibitor, curated by the Drug Signature D (more detail) 7 25990557 Homo sapiens
MEX001824
Genes associated with Kinase Inhibitor Kinome 575 Genes associated with Kinase Inhibitor Kinome_575, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002185
Genes associated with Kinase Inhibitor Kinome 507 Genes associated with Kinase Inhibitor Kinome_507, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX005340
Genes associated with Computational Drug Signature 1,5 Diaminopentane Genes associated with Computational Drug Signature 1,5-Diaminopentane, curated by the Drug Signature (more detail) 7 25990557 Homo sapiens
MOX002598
Genes associated with Computational Drug Signature 126861 72 1 Genes associated with Computational Drug Signature 126861-72-1, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX011447
Genes associated with Computational Drug Signature CHEMBL575896 Genes associated with Computational Drug Signature CHEMBL575896, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
MOX013311
Genes associated with Computational Drug Signature KT 6528 Genes associated with Computational Drug Signature KT 6528, curated by the Drug Signature Database ( (more detail) 7 25990557 Homo sapiens
GEX168000
Alcohol dependence Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replic (more detail) 7 23456092 Homo sapiens
PEX000267
BIR: Inhibitor of Apoptosis domain BIR stands for Baculovirus Inhibitor of apoptosis protein Repeat. It is found repeated in inhibitor (more detail) 7 NA Homo sapiens
PEX000047
Pyr redox: Pyridine nucleotide disulphide oxidoreductase This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidase (more detail) 7 NA Homo sapiens
MOX012707
Genes associated with Computational Drug Signature fluconazole Genes associated with Computational Drug Signature fluconazole, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX011736
Genes associated with Computational Drug Signature CHEMBL73495 Genes associated with Computational Drug Signature CHEMBL73495, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX014225
Genes associated with Computational Drug Signature Octyl Sulfamate Genes associated with Computational Drug Signature Octyl Sulfamate, curated by the Drug Signature Da (more detail) 7 25990557 Homo sapiens
WIG001015
Genes involved in Negative regulation of the PI3K/AKT network (more detail) 7 NA Homo sapiens
MEX001379
Genes associated with Kinase Inhibitor Kinome 683 Genes associated with Kinase Inhibitor Kinome_683, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001256
Genes associated with Kinase Inhibitor 1 [4 (4 amino 6 methylthieno[2,3 d]pyrimidin 5 yl)phenyl] 3 (3,5 dimethylphenyl)urea Genes associated with Kinase Inhibitor 1-[4-(4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]-3-( (more detail) 7 25990557 Homo sapiens
MEX002270
Genes associated with Kinase Inhibitor Tozasertib Genes associated with Kinase Inhibitor Tozasertib, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002330
Genes associated with Kinase Inhibitor Kinome 423 Genes associated with Kinase Inhibitor Kinome_423, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001808
Genes associated with Kinase Inhibitor TG003 Genes associated with Kinase Inhibitor TG003, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX003102
Genes associated with Computational Drug Signature 5 Hydroxydiclofenac Genes associated with Computational Drug Signature 5-Hydroxydiclofenac, curated by the Drug Signatur (more detail) 7 25990557 Homo sapiens
MOX006665
Genes associated with Computational Drug Signature AGN PC 001QKA Genes associated with Computational Drug Signature AGN-PC-001QKA, curated by the Drug Signature Data (more detail) 7 25990557 Homo sapiens
MOX006363
Genes associated with Computational Drug Signature 722544 51 6 Genes associated with Computational Drug Signature 722544-51-6, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
WAG000532
Removal of DNA patch containing abasic residue (more detail) 7 NA Homo sapiens
WIG001999
Acetylcholine Synthesis Acetylcholine Synthesis (more detail) 7 NA Homo sapiens
MEX001936
Genes associated with Kinase Inhibitor SU 5416 Genes associated with Kinase Inhibitor SU 5416, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001870
Genes associated with Kinase Inhibitor CHEMBL458415 Genes associated with Kinase Inhibitor CHEMBL458415, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MOX003935
Genes associated with Computational Drug Signature 2' deoxyguanosine Genes associated with Computational Drug Signature 2'-deoxyguanosine, curated by the Drug Signature (more detail) 7 25990557 Homo sapiens
MOX000978
Genes associated with Computational Drug Signature CHLORIC ACID Genes associated with Computational Drug Signature CHLORIC ACID, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
MOX002434
Genes associated with Computational Drug Signature 4450 98 0 Genes associated with Computational Drug Signature 4450-98-0, curated by the Drug Signature Database (more detail) 7 25990557 Homo sapiens
MOX006904
Genes associated with Computational Drug Signature allopurinol Genes associated with Computational Drug Signature allopurinol, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX009490
Genes associated with Computational Drug Signature CHEMBL294120 Genes associated with Computational Drug Signature CHEMBL294120, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
MOX011982
Genes associated with Computational Drug Signature Cipemastat Genes associated with Computational Drug Signature Cipemastat, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
PEX002507
RNase PH: 3' exoribonuclease family, domain 1 This family includes 3-5 exoribonucleases. Ribonuclease PH contains a single copy of this domain, a (more detail) 7 NA Homo sapiens
PEX002651
Asp: Eukaryotic aspartyl protease Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably a (more detail) 7 NA Homo sapiens
PEX000022
GSHPx: Glutathione peroxidase (more detail) 7 NA Homo sapiens
MOX015388
Genes associated with Computational Drug Signature SYRINGIC ACID Genes associated with Computational Drug Signature SYRINGIC ACID, curated by the Drug Signature Data (more detail) 7 25990557 Homo sapiens
MOX016010
Genes associated with Computational Drug Signature iproniazid Genes associated with Computational Drug Signature iproniazid, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
TAX013336
GO:0000270 biological process peptidoglycan metabolic process The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates foun (more detail) 7 NA Homo sapiens
WAG000514
Pyrimidine salvage reactions (more detail) 7 NA Homo sapiens
WAG000881
Cyclin A/B1 associated events during G2/M transition (more detail) 7 NA Homo sapiens
WIG002025
Arylamine metabolism Arylamine metabolism (more detail) 7 NA Homo sapiens
WIG001392
Oxidative Stress Regulatory Pathway (Erythrocyte) A simplified diagram to show several of the regulatory mechanisms that prevent oxidative stress in r (more detail) 7 NA Homo sapiens
MEX001322
Genes associated with Kinase Inhibitor CHEMBL189231 Genes associated with Kinase Inhibitor CHEMBL189231, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MOX014469
Genes associated with Computational Drug Signature Phenol, 4,4' (3 methyl 1 butenylidene)bis Genes associated with Computational Drug Signature Phenol, 4,4'-(3-methyl-1-butenylidene)bis-, curat (more detail) 7 25990557 Homo sapiens
MOX017603
Genes associated with Computational Drug Signature Methyltrienolone Genes associated with Computational Drug Signature Methyltrienolone, curated by the Drug Signature D (more detail) 7 25990557 Homo sapiens
PEX001937
RnaseA: Pancreatic ribonuclease Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold (more detail) 7 NA Homo sapiens
PEX001284
Hist deacetyl: Histone deacetylase domain Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is cau (more detail) 7 NA Homo sapiens
MOX015778
Genes associated with Computational Drug Signature UNII ZZ6VH5MZ17 Genes associated with Computational Drug Signature UNII-ZZ6VH5MZ17, curated by the Drug Signature Da (more detail) 7 25990557 Homo sapiens
MOX014397
Genes associated with Computational Drug Signature PD173955 Genes associated with Computational Drug Signature PD173955, curated by the Drug Signature Database (more detail) 7 25990557 Homo sapiens
MOX014637
Genes associated with Computational Drug Signature Prostratin Genes associated with Computational Drug Signature Prostratin, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
TAX013232
GO:0000052 biological process citrulline metabolic process The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino a (more detail) 7 NA Homo sapiens
FEX002728
Sarcoma Baird05 12genes Table 2. Tyrosine kinases and receptor tyrosine kinases associated with individual tumor groups (sho (more detail) 7 16230383 Homo sapiens
WAG000866
Aspartate, asparagine, glutamate, and glutamine metabolism (more detail) 7 NA Homo sapiens
WAG000334
mitochondrial fatty acid beta oxidation of saturated fatty acids (more detail) 7 NA Homo sapiens
MEX001660
Genes associated with Kinase Inhibitor GW827099X Genes associated with Kinase Inhibitor GW827099X, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001877
Genes associated with Kinase Inhibitor CHEMBL508928 Genes associated with Kinase Inhibitor CHEMBL508928, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MEX001619
Genes associated with Kinase Inhibitor GW410563A Genes associated with Kinase Inhibitor GW410563A, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001792
Genes associated with Kinase Inhibitor GSK994854A Genes associated with Kinase Inhibitor GSK994854A, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002157
Genes associated with Kinase Inhibitor Kinome 2847 Genes associated with Kinase Inhibitor Kinome_2847, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX000206
Genes associated with Computational Drug Signature 2 Nitroanisole Genes associated with Computational Drug Signature 2-Nitroanisole, curated by the Drug Signature Dat (more detail) 7 25990557 Homo sapiens
MOX003088
Genes associated with Computational Drug Signature Ranirestat Genes associated with Computational Drug Signature Ranirestat, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
MOX006350
Genes associated with Computational Drug Signature 7 Methoxycoumarin Genes associated with Computational Drug Signature 7-Methoxycoumarin, curated by the Drug Signature (more detail) 7 25990557 Homo sapiens
MOX005257
Genes associated with Computational Drug Signature (R) ( ) Rolipram Genes associated with Computational Drug Signature (R)-(-)-Rolipram, curated by the Drug Signature D (more detail) 7 25990557 Homo sapiens
MOX007218
Genes associated with Computational Drug Signature BENZOLAMIDE Genes associated with Computational Drug Signature BENZOLAMIDE, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX013168
Genes associated with Computational Drug Signature iproniazid Genes associated with Computational Drug Signature iproniazid, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
TAX013812
GO:0001758 molecular function retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis (more detail) 7 NA Homo sapiens
TAX013671
GO:0001517 molecular function N acetylglucosamine 6 O sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosin (more detail) 7 NA Homo sapiens
PEX000009
OTU: OTU like cysteine protease This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumou (more detail) 7 NA Homo sapiens
PEX000026
NAD binding 8: NAD(P) binding Rossmann like domain (more detail) 7 NA Homo sapiens
MOX011743
Genes associated with Computational Drug Signature CHEMBL74983 Genes associated with Computational Drug Signature CHEMBL74983, curated by the Drug Signature Databa (more detail) 7 25990557 Homo sapiens
MOX012111
Genes associated with Computational Drug Signature Cyclofenil diphenol Genes associated with Computational Drug Signature Cyclofenil diphenol, curated by the Drug Signatur (more detail) 7 25990557 Homo sapiens
MEX001637
Genes associated with Kinase Inhibitor MRT67307 Genes associated with Kinase Inhibitor MRT67307, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001754
Genes associated with Kinase Inhibitor Kinome 471 Genes associated with Kinase Inhibitor Kinome_471, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX001172
Genes associated with Computational Drug Signature naringenin chalcone Genes associated with Computational Drug Signature naringenin chalcone, curated by the Drug Signatur (more detail) 7 25990557 Homo sapiens
MOX006664
Genes associated with Computational Drug Signature AGN PC 001QK8 Genes associated with Computational Drug Signature AGN-PC-001QK8, curated by the Drug Signature Data (more detail) 7 25990557 Homo sapiens
MOX011418
Genes associated with Computational Drug Signature CHEMBL573935 Genes associated with Computational Drug Signature CHEMBL573935, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
MOX011199
Genes associated with Computational Drug Signature CHEMBL538718 Genes associated with Computational Drug Signature CHEMBL538718, curated by the Drug Signature Datab (more detail) 7 25990557 Homo sapiens
PEX001836
Amidohydro 1: Amidohydrolase family This family of enzymes are a a large metal dependent hydrolase superfamily 1. The family includes Ad (more detail) 7 NA Homo sapiens
PEX000832
Proteasome A N: Proteasome subunit A N terminal signature This domain is conserved in the A subunits of the proteasome complex proteins. (more detail) 7 NA Homo sapiens
MOX014751
Genes associated with Computational Drug Signature Racemetirosine Genes associated with Computational Drug Signature Racemetirosine, curated by the Drug Signature Dat (more detail) 7 25990557 Homo sapiens
MOX014316
Genes associated with Computational Drug Signature p coumaric acid Genes associated with Computational Drug Signature p-coumaric acid, curated by the Drug Signature Da (more detail) 7 25990557 Homo sapiens
WIG002019
Arachidonate Epoxygenase / Epoxide Hydrolase Arachidonate Epoxygenase / Epoxide Hydrolase (more detail) 7 NA Homo sapiens
WIG001415
Cyclophosphamide Pathway, Pharmacokinetics Model human liver cell showing genes involved in the metabolism of cyclophosphamide. (more detail) 7 NA Homo sapiens
MEX001399
Genes associated with Kinase Inhibitor MLS002232309 Genes associated with Kinase Inhibitor MLS002232309, curated by the Drug Signature Database (DSigDB) (more detail) 7 25990557 Homo sapiens
MEX001540
Genes associated with Kinase Inhibitor GW300660X Genes associated with Kinase Inhibitor GW300660X, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002065
Genes associated with Kinase Inhibitor Kinome 1078 Genes associated with Kinase Inhibitor Kinome_1078, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX000935
Genes associated with Computational Drug Signature TRIETHYLENE GLYCOL DIMETHACRYLATE Genes associated with Computational Drug Signature TRIETHYLENE GLYCOL DIMETHACRYLATE, curated by the (more detail) 7 25990557 Homo sapiens
MOX006051
Genes associated with Computational Drug Signature 4 cycloheptyliden(4 hydroxyphenyl)methylphenol Genes associated with Computational Drug Signature 4-cycloheptyliden(4-hydroxyphenyl)methylphenol, c (more detail) 7 25990557 Homo sapiens
MOX006666
Genes associated with Computational Drug Signature AGN PC 001QKE Genes associated with Computational Drug Signature AGN-PC-001QKE, curated by the Drug Signature Data (more detail) 7 25990557 Homo sapiens
PEX001610
Biotin lipoyl: Biotin requiring enzyme This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and l (more detail) 7 NA Homo sapiens
MOX014577
Genes associated with Computational Drug Signature PONATINIB Genes associated with Computational Drug Signature PONATINIB, curated by the Drug Signature Database (more detail) 7 25990557 Homo sapiens
MEX000887
Genes associated with Approved Drug propylthiouracil Genes associated with Approved Drug propylthiouracil, curated by the Drug Signature Database (DSigDB (more detail) 7 25990557 Homo sapiens
MEX001245
Genes associated with Kinase Inhibitor Kinome 131 Genes associated with Kinase Inhibitor Kinome_131, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX002022
Genes associated with Computational Drug Signature MY 5445 Genes associated with Computational Drug Signature MY-5445, curated by the Drug Signature Database ( (more detail) 7 25990557 Homo sapiens
MEX001693
Genes associated with Kinase Inhibitor Kinome 421 Genes associated with Kinase Inhibitor Kinome_421, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MOX005843
Genes associated with Computational Drug Signature 3 (4 Hydroxy phenyl) 2,3 diphenyl acrylonitrile Genes associated with Computational Drug Signature 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile, (more detail) 7 25990557 Homo sapiens
MOX016707
Genes associated with Computational Drug Signature nordihydroguaiaretate Genes associated with Computational Drug Signature nordihydroguaiaretate, curated by the Drug Signat (more detail) 7 25990557 Homo sapiens
PEX001128
Methyltransf 23: Methyltransferase domain This family appears to be a methyltransferase domain. (more detail) 7 NA Homo sapiens
PEX000006
ABC tran: ABC transporter ABC transporters for a large family of proteins responsible for translocation of a variety of compou (more detail) 7 NA Homo sapiens
PEX000031
Peptidase M14: Zinc carboxypeptidase (more detail) 7 NA Homo sapiens
PEX001617
Cullin: Cullin family (more detail) 7 NA Homo sapiens
MOX012200
Genes associated with Computational Drug Signature Decyl Sulfamate Genes associated with Computational Drug Signature Decyl Sulfamate, curated by the Drug Signature Da (more detail) 7 25990557 Homo sapiens
MOX014459
Genes associated with Computational Drug Signature Phenelzine Genes associated with Computational Drug Signature Phenelzine, curated by the Drug Signature Databas (more detail) 7 25990557 Homo sapiens
MEX000052
Genes associated with Approved Drug busulfan Genes associated with Approved Drug busulfan, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX001608
Genes associated with Kinase Inhibitor Kinome 332 Genes associated with Kinase Inhibitor Kinome_332, curated by the Drug Signature Database (DSigDB). (more detail) 7 25990557 Homo sapiens
MEX002271
Genes associated with Kinase Inhibitor Oxindole Based Inhibitor 80 Genes associated with Kinase Inhibitor Oxindole-Based Inhibitor 80, curated by the Drug Signature Da (more detail) 7 25990557 Homo sapiens
MOX002530
Genes associated with Computational Drug Signature Erucin Genes associated with Computational Drug Signature Erucin, curated by the Drug Signature Database (D (more detail) 7 25990557 Homo sapiens
TAX019497
GO:0018211 biological process peptidyl tryptophan modification The chemical alteration of a tryptophan residue in a peptide. (more detail) 7 NA Homo sapiens
TAX025316
GO:0045869 biological process negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral (more detail) 7 NA Homo sapiens
TAX014848
GO:0003916 molecular function DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through (more detail) 7 NA Homo sapiens
TAX014774
GO:0003720 molecular function telomerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes (more detail) 7 NA Homo sapiens
TAX014928
GO:0004032 molecular function alditol:NADP+ 1 oxidoreductase activity Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. (more detail) 7 NA Homo sapiens
TAX015311
GO:0004673 molecular function protein histidine kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. (more detail) 7 NA Homo sapiens
TAX016444
GO:0006578 biological process amino acid betaine biosynthetic process The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl deriv (more detail) 7 NA Homo sapiens
TAX022755
GO:0035184 molecular function histone threonine kinase activity Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any (more detail) 7 NA Homo sapiens
TAX017632
GO:0009253 biological process peptidoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of (more detail) 7 NA Homo sapiens
TAX024180
GO:0043140 molecular function ATP dependent 3' 5' DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the (more detail) 7 NA Homo sapiens
TAX024212
GO:0043190 cellular component ATP binding cassette (ABC) transporter complex A complex for the transport of metabolites into and out of the cell, typically comprised of four dom (more detail) 7 NA Homo sapiens
TAX019812
GO:0019784 molecular function NEDD8 specific protease activity Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated (more detail) 7 NA Homo sapiens
TAX025693
GO:0046654 biological process tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahyd (more detail) 7 NA Homo sapiens
TAX025475
GO:0046146 biological process tetrahydrobiopterin metabolic process The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2- (more detail) 7 NA Homo sapiens
TAX015142
GO:0004457 molecular function lactate dehydrogenase activity Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. (more detail) 7 NA Homo sapiens
TAX015545
GO:0005004 molecular function GPI linked ephrin receptor activity Combining with a GPI-anchored ephrin to initiate a change in cell activity. (more detail) 7 NA Homo sapiens
TAX015329
GO:0004703 molecular function G protein coupled receptor kinase activity Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosp (more detail) 7 NA Homo sapiens
TAX032343
GO:1902031 biological process regulation of NADP metabolic process Any process that modulates the frequency, rate or extent of NADP metabolic process. (more detail) 7 NA Homo sapiens
TAX017296
GO:0008479 molecular function queuine tRNA ribosyltransferase activity Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. (more detail) 7 NA Homo sapiens
TAX017916
GO:0010452 biological process histone H3 K36 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of (more detail) 7 NA Homo sapiens
TAX025565
GO:0046439 biological process L cysteine metabolic process The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptoprop (more detail) 7 NA Homo sapiens
TAX025581
GO:0046465 biological process dolichyl diphosphate metabolic process The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol deri (more detail) 7 NA Homo sapiens
TAX020497
GO:0030388 biological process fructose 1,6 bisphosphate metabolic process The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D en (more detail) 7 NA Homo sapiens
TAX016085
GO:0006032 biological process chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide co (more detail) 7 NA Homo sapiens
TAX015322
GO:0004691 molecular function cAMP dependent protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the pres (more detail) 7 NA Homo sapiens
WEX000080
Pentose Phosphate The genes related to pentose phosphate (metabolism) in tumor, immune, stroma using next-generation s (more detail) 7 NA Homo sapiens
TAX031537
GO:0102991 molecular function myristoyl CoA hydrolase activity Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A (more detail) 7 NA Homo sapiens
TAX028903
GO:0070383 biological process DNA cytosine deamination The removal of an amino group from a cytosine residue in DNA, forming a uracil residue. (more detail) 7 NA Homo sapiens
TAX023696
GO:0042148 biological process strand invasion The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the rec (more detail) 7 NA Homo sapiens
TAX022568
GO:0034627 biological process 'de novo' NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (more detail) 7 NA Homo sapiens
TAX017779
GO:0009820 biological process alkaloid metabolic process The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which (more detail) 7 NA Homo sapiens
TAX017532
GO:0009134 biological process nucleoside diphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compou (more detail) 7 NA Homo sapiens
TAX019023
GO:0016433 molecular function rRNA (adenine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA contain (more detail) 7 NA Homo sapiens
TAX015055
GO:0004321 molecular function fatty acyl CoA synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain ac (more detail) 7 NA Homo sapiens
TAX015557
GO:0005021 molecular function vascular endothelial growth factor activated receptor activity Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the pl (more detail) 7 NA Homo sapiens
TAX015230
GO:0004568 molecular function chitinase activity Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of c (more detail) 7 NA Homo sapiens
TAX015316
GO:0004679 molecular function AMP activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the pres (more detail) 7 NA Homo sapiens
TAX031491
GO:0102337 molecular function 3 oxo cerotoyl CoA synthase activity Catalysis of the reaction: tetracosanoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxohexacosanoyl-CoA + (more detail) 7 NA Homo sapiens
TAX015373
GO:0004767 molecular function sphingomyelin phosphodiesterase activity Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). (more detail) 7 NA Homo sapiens
TAX021456
GO:0032324 biological process molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), (more detail) 7 NA Homo sapiens
TAX022682
GO:0034983 biological process peptidyl lysine deacetylation The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. (more detail) 7 NA Homo sapiens
TAX022691
GO:0035005 molecular function 1 phosphatidylinositol 4 phosphate 3 kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo- (more detail) 7 NA Homo sapiens
TAX023332
GO:0036310 molecular function annealing helicase activity Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between (more detail) 7 NA Homo sapiens
TAX016557
GO:0006729 biological process tetrahydrobiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced f (more detail) 7 NA Homo sapiens
TAX024434
GO:0043545 biological process molybdopterin cofactor metabolic process The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the c (more detail) 7 NA Homo sapiens
TAX019329
GO:0017002 molecular function activin activated receptor activity Combining with activin and transmitting the signal from one side of the membrane to the other to ini (more detail) 7 NA Homo sapiens
TAX019695
GO:0019367 biological process fatty acid elongation, saturated fatty acid Elongation of a saturated fatty acid chain. (more detail) 7 NA Homo sapiens
TAX019713
GO:0019405 biological process alditol catabolic process The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol d (more detail) 7 NA Homo sapiens
TAX019505
GO:0018243 biological process protein O linked glycosylation via threonine The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; (more detail) 7 NA Homo sapiens
TAX019247
GO:0016833 molecular function oxo acid lyase activity Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydro (more detail) 7 NA Homo sapiens
TAX019884
GO:0019919 biological process peptidyl arginine methylation, to asymmetrical dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-argini (more detail) 7 NA Homo sapiens
TAX015149
GO:0004465 molecular function lipoprotein lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacyl (more detail) 7 NA Homo sapiens
TAX031492
GO:0102338 molecular function 3 oxo lignoceronyl CoA synthase activity Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxotetracosanoyl-CoA. + car (more detail) 7 NA Homo sapiens
TAX021306
GO:0032049 biological process cardiolipin biosynthetic process The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidy (more detail) 7 NA Homo sapiens
TAX014996
GO:0004128 molecular function cytochrome b5 reductase activity, acting on NAD(P)H Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). (more detail) 7 NA Homo sapiens
TAX016368
GO:0006489 biological process dolichyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphor (more detail) 7 NA Homo sapiens
TAX017185
GO:0008297 molecular function single stranded DNA exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-st (more detail) 7 NA Homo sapiens
TAX029009
GO:0070569 molecular function uridylyltransferase activity Catalysis of the transfer of an uridylyl group to an acceptor. (more detail) 7 NA Homo sapiens
TAX017774
GO:0009804 biological process coumarin metabolic process The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic sk (more detail) 7 NA Homo sapiens
TAX019696
GO:0019368 biological process fatty acid elongation, unsaturated fatty acid Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced. (more detail) 7 NA Homo sapiens
TAX024155
GO:0043102 biological process amino acid salvage Any process which produces an amino acid from derivatives of it, without de novo synthesis. (more detail) 7 NA Homo sapiens
TAX024489
GO:0043633 biological process polyadenylation dependent RNA catabolic process The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by init (more detail) 7 NA Homo sapiens
TAX019253
GO:0016842 molecular function amidine lyase activity Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reve (more detail) 7 NA Homo sapiens
TAX018969
GO:0016308 molecular function 1 phosphatidylinositol 4 phosphate 5 kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo- (more detail) 7 NA Homo sapiens
TAX016084
GO:0006030 biological process chitin metabolic process The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1- (more detail) 7 NA Homo sapiens
TAX015277
GO:0004630 molecular function phospholipase D activity Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. (more detail) 7 NA Homo sapiens
TAX016503
GO:0006657 biological process CDP choline pathway The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and end (more detail) 7 NA Homo sapiens
TAX022567
GO:0034626 biological process fatty acid elongation, polyunsaturated fatty acid Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced. (more detail) 7 NA Homo sapiens
TAX019818
GO:0019798 molecular function procollagen proline dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L (more detail) 7 NA Homo sapiens
TAX019173
GO:0016714 molecular function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred (more detail) 7 NA Homo sapiens
TAX019535
GO:0018406 biological process protein C linked glycosylation via 2' alpha mannosyl L tryptophan The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolic (more detail) 7 NA Homo sapiens
TAX014843
GO:0003909 molecular function DNA ligase activity Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one (more detail) 7 NA Homo sapiens
TAX020450
GO:0030309 biological process poly N acetyllactosamine metabolic process The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N (more detail) 7 NA Homo sapiens
TAX021417
GO:0032261 biological process purine nucleotide salvage Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis. (more detail) 7 NA Homo sapiens
TAX017348
GO:0008559 molecular function xenobiotic transmembrane transporting ATPase activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). (more detail) 7 NA Homo sapiens
TAX016418
GO:0006551 biological process leucine metabolic process The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid. (more detail) 7 NA Homo sapiens
TAX017289
GO:0008467 molecular function [heparan sulfate] glucosamine 3 sulfotransferase 1 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3' (more detail) 7 NA Homo sapiens
TAX016869
GO:0007256 biological process activation of JNKK activity The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are i (more detail) 7 NA Homo sapiens
TAX017699
GO:0009445 biological process putrescine metabolic process The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be forme (more detail) 7 NA Homo sapiens
TAX017520
GO:0009120 biological process deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of (more detail) 7 NA Homo sapiens
TAX019459
GO:0018103 biological process protein C linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to (more detail) 7 NA Homo sapiens
TAX019518
GO:0018317 biological process protein C linked glycosylation via tryptophan The glycosylation of a carbon atom of a peptidyl-tryptophan residue. (more detail) 7 NA Homo sapiens
TAX026861
GO:0051189 biological process prosthetic group metabolic process The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of cert (more detail) 7 NA Homo sapiens
TAX015850
GO:0005655 cellular component nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' en (more detail) 7 NA Homo sapiens
TAX014900
GO:0003993 molecular function acid phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid (more detail) 7 NA Homo sapiens
TAX015345
GO:0004723 molecular function calcium dependent protein serine/threonine phosphatase activity Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein (more detail) 7 NA Homo sapiens
WEX000029
Fatty Acid Oxidation The genes related to fatty acid oxidation (metabolism) in tumor, immune, stroma using next-generatio (more detail) 7 NA Homo sapiens
TAX023840
GO:0042439 biological process ethanolamine containing compound metabolic process The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived fr (more detail) 7 NA Homo sapiens
TAX031490
GO:0102336 molecular function 3 oxo arachidoyl CoA synthase activity Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon (more detail) 7 NA Homo sapiens
TAX031526
GO:0102756 molecular function very long chain 3 ketoacyl CoA synthase activity Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon d (more detail) 7 NA Homo sapiens
TAX017272
GO:0008443 molecular function phosphofructokinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate mol (more detail) 7 NA Homo sapiens
TAX022773
GO:0035242 molecular function protein arginine omega N asymmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is o (more detail) 7 NA Homo sapiens
TAX017102
GO:0008172 molecular function S methyltransferase activity Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. (more detail) 7 NA Homo sapiens
TAX017135
GO:0008215 biological process spermine metabolic process The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in r (more detail) 7 NA Homo sapiens
TAX022861
GO:0035405 biological process histone threonine phosphorylation The modification of histones by addition of a phosphate group to a threonine residue. (more detail) 7 NA Homo sapiens
TAX022566
GO:0034625 biological process fatty acid elongation, monounsaturated fatty acid Elongation of a fatty acid chain into which one C-C double bond has been introduced. (more detail) 7 NA Homo sapiens
TAX016582
GO:0006768 biological process biotin metabolic process The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4 (more detail) 7 NA Homo sapiens
TAX029356
GO:0071267 biological process L methionine salvage Any process that generates L-methionine from derivatives of it, without de novo synthesis. (more detail) 7 NA Homo sapiens
TAX017745
GO:0009698 biological process phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. (more detail) 7 NA Homo sapiens
TAX017808
GO:0009922 molecular function fatty acid elongase activity Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C). (more detail) 7 NA Homo sapiens
TAX018856
GO:0016078 biological process tRNA catabolic process The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of rel (more detail) 7 NA Homo sapiens
TAX025879
GO:0047134 molecular function protein disulfide reductase activity Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. (more detail) 7 NA Homo sapiens
TAX015289
GO:0004645 molecular function phosphorylase activity Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D (more detail) 7 NA Homo sapiens
TAX015347
GO:0004726 molecular function non membrane spanning protein tyrosine phosphatase activity Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spa (more detail) 7 NA Homo sapiens
MOX006011
Genes associated with Computational Drug Signature 4 Amino 1,8 naphthalimide Genes associated with Computational Drug Signature 4-Amino-1,8-naphthalimide, curated by the Drug Si (more detail) 13 25990557 Homo sapiens
MOX003268
Genes associated with Computational Drug Signature Dehydroxymethylepoxyquinomicin Genes associated with Computational Drug Signature Dehydroxymethylepoxyquinomicin, curated by the Dr (more detail) 13 25990557 Homo sapiens
MOX004760
Genes associated with Computational Drug Signature THYMOL Genes associated with Computational Drug Signature THYMOL, curated by the Drug Signature Database (D (more detail) 13 25990557 Homo sapiens
MOX000324
Genes associated with Computational Drug Signature 2,2' Bioxirane Genes associated with Computational Drug Signature 2,2'-Bioxirane, curated by the Drug Signature Dat (more detail) 13 25990557 Homo sapiens
MEX002661
Genes associated with Perturbagen Signature BCB000039 Genes associated with Perturbagen Signature BCB000039, curated by the Drug Signature Database (DSigD (more detail) 13 25990557 Homo sapiens
WIG001334
Platinum Pathway, Pharmacokinetics/Pharmacodynamics Representation of the candidate genes involved in the metabolism of platinum containing drugs. (more detail) 13 NA Homo sapiens
WIG000250
Hemoglobin's Chaperone The function of hemoglobin in oxygen transport by red blood cells requires precise assembly of a tet (more detail) 13 NA Homo sapiens
WIG000301
D4 GDI Signaling Pathway D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras related Rho Family of GTPases (more detail) 13 NA Homo sapiens
MOX002107
Genes associated with Computational Drug Signature O,P' DDE Genes associated with Computational Drug Signature O,P'-DDE, curated by the Drug Signature Database (more detail) 13 25990557 Homo sapiens
MOX003909
Genes associated with Computational Drug Signature L cysteine Genes associated with Computational Drug Signature L-cysteine, curated by the Drug Signature Databas (more detail) 13 25990557 Homo sapiens
FEX003379
Viral Ruutu02 16genes Table I ? Upregulated Genes in all Passages of UT-DEC-1 (an HPV-33-positive cell line) Compared to C (more detail) 13 12115547 Homo sapiens
MOX005361
Genes associated with Computational Drug Signature 1 (3,4 Dichlorobenzyl) 1H indole 2,3 dione Genes associated with Computational Drug Signature 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione, curat (more detail) 13 25990557 Homo sapiens
MOX006256
Genes associated with Computational Drug Signature 6,7 Dimethyl 2 phenylquinoxaline Genes associated with Computational Drug Signature 6,7-Dimethyl-2-phenylquinoxaline, curated by the (more detail) 13 25990557 Homo sapiens
MOX003404
Genes associated with Computational Drug Signature Talmapimod Genes associated with Computational Drug Signature Talmapimod, curated by the Drug Signature Databas (more detail) 13 25990557 Homo sapiens
MOX017636
Genes associated with Computational Drug Signature 1 Methyl 3 nitro 1 nitrosoguanidine Genes associated with Computational Drug Signature 1-Methyl-3-nitro-1-nitrosoguanidine, curated by t (more detail) 13 25990557 Homo sapiens
WIG000278
CBL mediated ligand induced downregulation of EGF receptors As with many cell-surface receptors, activation of the EGF receptor can result in receptor internali (more detail) 13 NA Homo sapiens
MOX016663
Genes associated with Computational Drug Signature methoxsalen Genes associated with Computational Drug Signature methoxsalen, curated by the Drug Signature Databa (more detail) 13 25990557 Homo sapiens
MOX003212
Genes associated with Computational Drug Signature Roflumilast Genes associated with Computational Drug Signature Roflumilast, curated by the Drug Signature Databa (more detail) 13 25990557 Homo sapiens
TAX023700
GO:0042159 biological process lipoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble prot (more detail) 13 NA Homo sapiens
IEI014275
Protein protein interactors of human gene TRIM74 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM74 (SwissProt ID (more detail) 13 17535438 Homo sapiens
TAX017882
GO:0010248 biological process establishment or maintenance of transmembrane electrochemical gradient The directed movement of ions to establish or maintain an electrochemical gradient across a membrane (more detail) 13 NA Homo sapiens
TAX016459
GO:0006596 biological process polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound c (more detail) 13 NA Homo sapiens
IEI008622
Protein protein interactors of human gene NCF4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene NCF4 (SwissProt ID=Q (more detail) 13 17535438 Homo sapiens
TAX032025
GO:1901160 biological process primary amino compound metabolic process The chemical reactions and pathways involving primary amino compound. (more detail) 13 NA Homo sapiens
TAX031261
GO:0098993 cellular component anchored component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of the gene products that are tethered to (more detail) 13 NA Homo sapiens
TAX016606
GO:0006809 biological process nitric oxide biosynthetic process The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (N (more detail) 13 NA Homo sapiens
TAX019722
GO:0019430 biological process removal of superoxide radicals Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cel (more detail) 13 NA Homo sapiens
TAX029756
GO:0071941 biological process nitrogen cycle metabolic process A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is (more detail) 13 NA Homo sapiens
IEI000332
Protein protein interactors of human gene AFAP1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene AFAP1 (SwissProt ID= (more detail) 13 17535438 Homo sapiens
IEI004296
Protein protein interactors of human gene ESCO2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ESCO2 (SwissProt ID= (more detail) 13 17535438 Homo sapiens
IEI007782
Protein protein interactors of human gene MCCC1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene MCCC1 (SwissProt ID= (more detail) 13 17535438 Homo sapiens
IEI003982
Protein protein interactors of human gene EFNA5 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EFNA5 (SwissProt ID= (more detail) 13 17535438 Homo sapiens
IEI004989
Protein protein interactors of human gene GAB3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene GAB3 (SwissProt ID=Q (more detail) 9 17535438 Homo sapiens
IEI006261
Protein protein interactors of human gene IGLC1 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene IGLC1 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
IEI000385
Protein protein interactors of human gene AHCYL2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene AHCYL2 (SwissProt ID (more detail) 9 17535438 Homo sapiens
IEI014238
Protein protein interactors of human gene TRIM34 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene TRIM34 (SwissProt ID (more detail) 9 17535438 Homo sapiens
TAX025438
GO:0046085 biological process adenosine metabolic process The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found wi (more detail) 9 NA Homo sapiens
TAX026486
GO:0050650 biological process chondroitin sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, (more detail) 9 NA Homo sapiens
IEI001403
Protein protein interactors of human gene BORA from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene BORA (SwissProt ID=Q (more detail) 9 17535438 Homo sapiens
TAX021477
GO:0032357 molecular function oxidized purine DNA binding Interacting selectively and non-covalently with oxidized purine residues in DNA. (more detail) 9 NA Homo sapiens
TAX016439
GO:0006573 biological process valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. (more detail) 9 NA Homo sapiens
TAX026490
GO:0050654 biological process chondroitin sulfate proteoglycan metabolic process The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein who (more detail) 9 NA Homo sapiens
TAX023292
GO:0036157 cellular component outer dynein arm Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Out (more detail) 9 NA Homo sapiens
TAX021235
GO:0031936 biological process negative regulation of chromatin silencing Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing. (more detail) 9 NA Homo sapiens
TAX034688
GO:2000425 biological process regulation of apoptotic cell clearance Any process that modulates the frequency, rate or extent of apoptotic cell clearance. (more detail) 9 NA Homo sapiens
IEI000972
Protein protein interactors of human gene ASCL2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ASCL2 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
TAX019781
GO:0019695 biological process choline metabolic process The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino al (more detail) 9 NA Homo sapiens
TAX016214
GO:0006265 biological process DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded D (more detail) 9 NA Homo sapiens
TAX024015
GO:0042776 biological process mitochondrial ATP synthesis coupled proton transport The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (pr (more detail) 9 NA Homo sapiens
TAX031751
GO:0150065 biological process regulation of deacetylase activity Any process that modulates the frequency, rate or extent of deacetylase activity. (more detail) 9 NA Homo sapiens
IEI010497
Protein protein interactors of human gene PRKG2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PRKG2 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
IEI011127
Protein protein interactors of human gene RCBTB2 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RCBTB2 (SwissProt ID (more detail) 9 17535438 Homo sapiens
TAX030481
GO:0090308 biological process regulation of methylation dependent chromatin silencing Any process that modulates the rate, frequency, or extent of the repression of transcription by meth (more detail) 9 NA Homo sapiens
TAX024945
GO:0045091 biological process regulation of single stranded viral RNA replication via double stranded DNA intermediate Any process that modulates the frequency, rate or extent of single stranded viral RNA replication vi (more detail) 9 NA Homo sapiens
TAX019765
GO:0019614 biological process catechol containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Cat (more detail) 9 NA Homo sapiens
TAX023796
GO:0042363 biological process fat soluble vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins (more detail) 9 NA Homo sapiens
TAX022916
GO:0035520 biological process monoubiquitinated protein deubiquitination The removal of the ubiquitin group from a monoubiquitinated protein. (more detail) 9 NA Homo sapiens
TAX019702
GO:0019374 biological process galactolipid metabolic process The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more r (more detail) 9 NA Homo sapiens
TAX022022
GO:0033182 biological process regulation of histone ubiquitination Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a h (more detail) 9 NA Homo sapiens
IEI003981
Protein protein interactors of human gene EFNA4 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene EFNA4 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
TAX023831
GO:0042424 biological process catecholamine catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically (more detail) 9 NA Homo sapiens
TAX027233
GO:0051880 molecular function G quadruplex DNA binding Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four (more detail) 9 NA Homo sapiens
TAX020600
GO:0030647 biological process aminoglycoside antibiotic metabolic process The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of (more detail) 9 NA Homo sapiens
IEI003243
Protein protein interactors of human gene CYP2C9 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene CYP2C9 (SwissProt ID (more detail) 9 17535438 Homo sapiens
IEI003407
Protein protein interactors of human gene DDX11 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene DDX11 (SwissProt ID= (more detail) 9 17535438 Homo sapiens
WAG001258
regulation of splicing through sam68 While transcriptiol regulation is often viewed as the most prevalent way extracellular sigls to regu (more detail) 9 NA Homo sapiens
MOX004554
Genes associated with Computational Drug Signature Methylmitomycin Genes associated with Computational Drug Signature Methylmitomycin, curated by the Drug Signature Da (more detail) 9 25990557 Homo sapiens
WIG001526
Glutathione Metabolism in M. musculus Glutathione Metabolism in M. musculus (more detail) 9 NA Homo sapiens
TAX000442
Genes annotated by the GO term GO:0009225. The chemical reactions and pathways involving nucleotide sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5' diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. (more detail) 9 NA Homo sapiens
WIG001345
Clopidogrel Pathway, Pharmacokinetics Clopidogrel metabolism. (more detail) 9 NA Homo sapiens
MOX015748
Genes associated with Computational Drug Signature UNII J8AY0Z4CBP Genes associated with Computational Drug Signature UNII-J8AY0Z4CBP, curated by the Drug Signature Da (more detail) 9 25990557 Homo sapiens
MOX016871
Genes associated with Computational Drug Signature guaiacol Genes associated with Computational Drug Signature guaiacol, curated by the Drug Signature Database (more detail) 9 25990557 Homo sapiens
MOX004685
Genes associated with Computational Drug Signature STERIGMATOCYSTIN Genes associated with Computational Drug Signature STERIGMATOCYSTIN, curated by the Drug Signature D (more detail) 9 25990557 Homo sapiens
MOX005434
Genes associated with Computational Drug Signature 1 NM PP1 Genes associated with Computational Drug Signature 1-NM-PP1, curated by the Drug Signature Database (more detail) 9 25990557 Homo sapiens
MOX004420
Genes associated with Computational Drug Signature nitrazepam Genes associated with Computational Drug Signature nitrazepam, curated by the Drug Signature Databas (more detail) 9 25990557 Homo sapiens
MOX000957
Genes associated with Computational Drug Signature Hyperoside Genes associated with Computational Drug Signature Hyperoside, curated by the Drug Signature Databas (more detail) 9 25990557 Homo sapiens
MOX005589
Genes associated with Computational Drug Signature 2,6 Di tert butyl 4 methylphenol Genes associated with Computational Drug Signature 2,6-Di-tert-butyl-4-methylphenol, curated by the (more detail) 9 25990557 Homo sapiens
MOX004598
Genes associated with Computational Drug Signature Pyocyanin Genes associated with Computational Drug Signature Pyocyanin, curated by the Drug Signature Database (more detail) 9 25990557 Homo sapiens
GEX166599
HDL cholesterol Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (more detail) 9 18193043 Homo sapiens
GEX000343
cancer cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated (more detail) 9 NA Homo sapiens
FEX003497
Viral Cairo08 14genes Table S8. Overrepresented pathways (p (more detail) 9 19061838 Homo sapiens
MEX000568
Genes associated with Approved Drug diltiazem Genes associated with Approved Drug diltiazem, curated by the Drug Signature Database (DSigDB). (more detail) 9 25990557 Homo sapiens
MOX000598
Genes associated with Computational Drug Signature 6 HYDROXYMELATONIN Genes associated with Computational Drug Signature 6-HYDROXYMELATONIN, curated by the Drug Signature (more detail) 9 25990557 Homo sapiens
MOX004502
Genes associated with Computational Drug Signature Phenelzine Genes associated with Computational Drug Signature Phenelzine, curated by the Drug Signature Databas (more detail) 9 25990557 Homo sapiens
MOX016789
Genes associated with Computational Drug Signature prostaglandin h2 Genes associated with Computational Drug Signature prostaglandin h2, curated by the Drug Signature D (more detail) 9 25990557 Homo sapiens
MOX001367
Genes associated with Computational Drug Signature Tris(2 chloroethyl) phosphate Genes associated with Computational Drug Signature Tris(2-chloroethyl) phosphate, curated by the Dru (more detail) 9 25990557 Homo sapiens
GEX167928
Metabolite levels A genome-wide assessment of variability in human serum metabolism. (more detail) 9 23281178 Homo sapiens
TAX013771
GO:0001682 biological process tRNA 5' leader removal Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. (more detail) 9 NA Homo sapiens
MOX016671
Genes associated with Computational Drug Signature dTTP Genes associated with Computational Drug Signature dTTP, curated by the Drug Signature Database (DSi (more detail) 9 25990557 Homo sapiens
MOX015544
Genes associated with Computational Drug Signature ticlopidine Genes associated with Computational Drug Signature ticlopidine, curated by the Drug Signature Databa (more detail) 9 25990557 Homo sapiens
WIG000856
Genes involved in G2/M DNA damage checkpoint (more detail) 9 NA Homo sapiens
MOX003167
Genes associated with Computational Drug Signature Almotriptan Genes associated with Computational Drug Signature Almotriptan, curated by the Drug Signature Databa (more detail) 9 25990557 Homo sapiens
MOX010669
Genes associated with Computational Drug Signature CHEMBL448246 Genes associated with Computational Drug Signature CHEMBL448246, curated by the Drug Signature Datab (more detail) 9 25990557 Homo sapiens
MOX014154
Genes associated with Computational Drug Signature NSC172033 Genes associated with Computational Drug Signature NSC172033, curated by the Drug Signature Database (more detail) 9 25990557 Homo sapiens
MOX001834
Genes associated with Computational Drug Signature NSC336628 Genes associated with Computational Drug Signature NSC336628, curated by the Drug Signature Database (more detail) 9 25990557 Homo sapiens
MOX002838
Genes associated with Computational Drug Signature CTK2F5402 Genes associated with Computational Drug Signature CTK2F5402, curated by the Drug Signature Database (more detail) 9 25990557 Homo sapiens
MOX002276
Genes associated with Computational Drug Signature Benidipine Genes associated with Computational Drug Signature Benidipine, curated by the Drug Signature Databas (more detail) 9 25990557 Homo sapiens
MOX008615
Genes associated with Computational Drug Signature CHEMBL204357 Genes associated with Computational Drug Signature CHEMBL204357, curated by the Drug Signature Datab (more detail) 9 25990557 Homo sapiens
GEX000310
brain cancer brain cancer associated genes. PAGER constructed this gene set by grouping all genes which are assoc (more detail) 9 NA Homo sapiens
FOX000822
Genes in the cancer module 65 (more detail) 9 NA Homo sapiens
MEX000560
Genes associated with Approved Drug halofantrine hydrochloride Genes associated with Approved Drug halofantrine hydrochloride, curated by the Drug Signature Databa (more detail) 9 25990557 Homo sapiens
MOX004078
Genes associated with Computational Drug Signature 1 Ethyl 1 nitrosourea Genes associated with Computational Drug Signature 1-Ethyl-1-nitrosourea, curated by the Drug Signat (more detail) 9 25990557 Homo sapiens
MOX001810
Genes associated with Computational Drug Signature N Chlorothylnitrosourea sarcosinamide Genes associated with Computational Drug Signature N-Chlorothylnitrosourea sarcosinamide, curated by (more detail) 9 25990557 Homo sapiens
WAG000883
Displacement of DNA glycosylase by APE1 (more detail) 9 NA Homo sapiens
TAX000914
Genes annotated by the GO term GO:0030173. Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. (more detail) 9 NA Homo sapiens
TAX016134
GO:0006105 biological process succinate metabolic process The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarb (more detail) 11 NA Homo sapiens
TAX016542
GO:0006702 biological process androgen biosynthetic process The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones th (more detail) 11 NA Homo sapiens
TAX016430
GO:0006563 biological process L serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amin (more detail) 11 NA Homo sapiens
TAX016148
GO:0006122 biological process mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylatio (more detail) 11 NA Homo sapiens
TAX033388
GO:1904321 biological process response to forskolin Any process that results in a change in state or activity of a cell or an organism (in terms of move (more detail) 11 NA Homo sapiens
TAX020834
GO:0031125 biological process rRNA 3' end processing Any process involved in forming the mature 3' end of an rRNA molecule. (more detail) 11 NA Homo sapiens
TAX034842
GO:2000650 biological process negative regulation of sodium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembran (more detail) 11 NA Homo sapiens
IEI010773
Protein protein interactors of human gene PTX3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene PTX3 (SwissProt ID=P (more detail) 11 17535438 Homo sapiens
IEI001257
Protein protein interactors of human gene BCAN from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene BCAN (SwissProt ID=Q (more detail) 11 17535438 Homo sapiens
IEI011564
Protein protein interactors of human gene RPP40 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RPP40 (SwissProt ID= (more detail) 11 17535438 Homo sapiens
IEI011027
Protein protein interactors of human gene RASGRP3 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene RASGRP3 (SwissProt I (more detail) 11 17535438 Homo sapiens
TAX015793
GO:0005536 molecular function glucose binding Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. (more detail) 11 NA Homo sapiens
TAX016454
GO:0006590 biological process thyroid hormone generation The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodo (more detail) 11 NA Homo sapiens
IEI000814
Protein protein interactors of human gene ARHGAP26 from the Interologous Interaction Database ver 2.9 This PAG records all the protein-protein interaction partners of the human gene ARHGAP26 (SwissProt (more detail) 11 17535438 Homo sapiens
TAX033389
GO:1904322 biological process cellular response to forskolin Any process that results in a change in state or activity of a cell (in terms of movement, secretion (more detail) 11 NA Homo sapiens
TAX019086
GO:0016553 biological process base conversion or substitution editing Any base modification or substitution events that result in alterations in the coding potential or s (more detail) 11 NA Homo sapiens
MOX002483
Genes associated with Computational Drug Signature 2 Propenamide, 2 cyano 3 (3,4 dihydroxy 5 nitrophenyl) N,N diethyl Genes associated with Computational Drug Signature 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitroph (more detail) 11 25990557 Homo sapiens
TAX000048
Genes annotated by the GO term GO:0008206. The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. (more detail) 11 NA Homo sapiens
WIG000396
Deregulation of CDK5 in Alzheimers Disease Cyclin-dependent kinase 5 (cdk5), a multi-functional kinase, and its neuron-specific activator p35 a (more detail) 11 NA Homo sapiens
WIG000152
Sumoylation by RanBP2 regulates transcriptional repression (more detail) 11 NA Homo sapiens
MEX000623
Genes associated with Approved Drug zileuton Genes associated with Approved Drug zileuton, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MOX003674
Genes associated with Computational Drug Signature amoxicillin Genes associated with Computational Drug Signature amoxicillin, curated by the Drug Signature Databa (more detail) 11 25990557 Homo sapiens
FEX002085
Lung not cancer Harvey06 11genes Table 2. Examples of genes differentially expressed in the small airway epithelium in nonsmokers and (more detail) 11 17115125 Homo sapiens
MOX015669
Genes associated with Computational Drug Signature Tyrphostin AG 1478 Genes associated with Computational Drug Signature Tyrphostin AG 1478, curated by the Drug Signature (more detail) 11 25990557 Homo sapiens
WAG000299
Gab1 signalosome (more detail) 11 NA Homo sapiens
TAX000241
Genes annotated by the GO term GO:0006516. The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. (more detail) 11 NA Homo sapiens
MOX012791
Genes associated with Computational Drug Signature Galangin Genes associated with Computational Drug Signature Galangin, curated by the Drug Signature Database (more detail) 11 25990557 Homo sapiens
WIG000411
Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle Sonic Hedgehog (Shh) is a secreted protein identified genetically as an important developmental fact (more detail) 11 NA Homo sapiens
WIG001316
Genes involved in Vitamin B5 (pantothenate) metabolism (more detail) 11 NA Homo sapiens
MEX000552
Genes associated with Approved Drug zidovudine Genes associated with Approved Drug zidovudine, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MEX000413
Genes associated with Approved Drug ampicillin Genes associated with Approved Drug ampicillin, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
MOX001218
Genes associated with Computational Drug Signature 3',4' Dihydroxyflavone Genes associated with Computational Drug Signature 3',4'-Dihydroxyflavone, curated by the Drug Signa (more detail) 11 25990557 Homo sapiens
TAX000212
Genes annotated by the GO term GO:0006635. The metabolic oxidation of a long chain fatty acid by successive cycles of reactions during each of which the fatty acid is shortened by a two carbon fragment removed as acetyl coenzyme A. (more detail) 11 NA Homo sapiens
MEX001200
Genes associated with Approved Drug Sirolimus Genes associated with Approved Drug Sirolimus, curated by the Drug Signature Database (DSigDB). (more detail) 11 25990557 Homo sapiens
FEX002587
Prostate Bigler03 11genes Table 1. Genes on HG-U95AV2 Affymetrix oligonucleotide arrays which had a significantly altered exp (more detail) 11 12606954 Homo sapiens
WAG001017
hemoglobins chaperone The function of hemoglobin in oxygen transport by red blood cells requires precise assembly of a tet (more detail) 11 NA Homo sapiens
MOX017777
Genes associated with Computational Drug Signature sulfaphenazole Genes associated with Computational Drug Signature sulfaphenazole, curated by the Drug Signature Dat (more detail) 11 25990557 Homo sapiens
MOX004570
Genes associated with Computational Drug Signature PRIMAQUINE Genes associated with Computational Drug Signature PRIMAQUINE, curated by the Drug Signature Databas (more detail) 11 25990557 Homo sapiens
MOX002148
Genes associated with Computational Drug Signature ML 9 Genes associated with Computational Drug Signature ML-9, curated by the Drug Signature Database (DSi (more detail) 11 25990557 Homo sapiens
TAX000254
Genes annotated by the GO term GO:0042168. The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. (more detail) 11 NA Homo sapiens
WIG000368
Reversal of Insulin Resistance by Leptin The insulin resistance of type II diabetes appears to be caused in part by the presence of high leve (more detail) 11 NA Homo sapiens
FEX002661
Prostate Biancolella07 11genes Table 1 Genes differentially expressed in LNCaP treated with Dutasteride (more detail) 11 17636412 Homo sapiens
MOX016985
Genes associated with Computational Drug Signature gamma Linolenic acid Genes associated with Computational Drug Signature gamma-Linolenic acid, curated by the Drug Signatu (more detail) 11 25990557 Homo sapiens
MOX003005
Genes associated with Computational Drug Signature Perifosine Genes associated with Computational Drug Signature Perifosine, curated by the Drug Signature Databas (more detail) 11 25990557 Homo sapiens
MOX003625
Genes associated with Computational Drug Signature aconitine Genes associated with Computational Drug Signature aconitine, curated by the Drug Signature Database (more detail) 11 25990557 Homo sapiens
TAX000825
Genes annotated by the GO term GO:0006805. The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. (more detail) 11 NA Homo sapiens
TAX000445
Genes annotated by the GO term GO:0009311. The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. (more detail) 11 NA Homo sapiens
TAX000243
Genes annotated by the GO term GO:0006687. The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. (more detail) 11 NA Homo sapiens
MOX014713
Genes associated with Computational Drug Signature quercitrin Genes associated with Computational Drug Signature quercitrin, curated by the Drug Signature Databas (more detail) 11 25990557 Homo sapiens
WAG000861
Sumoylation by RanBP2 regulates transcriptional repression (more detail) 11 NA Homo sapiens
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GOA 
