GS_ID NAME GS_SIZE ORGANISM DESCRIPTION LINK REFERENCE PUBMED_ID CATEGORY STATUS CURATOR CURATOR_CONTACT CONTRIBUTED_BY FLAG COCO_V2 GO_FLAG VERSION REF_OLD_ID ORIGINAL_ID RECORD_DATE SOURCE TYPE SOURCE_RECORD
FAX000342 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCTY which matches annotation for ESRRA: estrogen-related receptor alpha 955 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCTY which matches annotation for ESRRA: estrogen-related receptor alpha http://www.broadinstitute.org/gsea/msigdb/cards/TGACCTY_V$ERR1_Q2 M11396 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 10.035541492394 N 1.0 13-AUG-20 MSigDB A 13229
FAX000345 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGANTCA which matches annotation for JUN: jun oncogene 1048 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGANTCA which matches annotation for JUN: jun oncogene http://www.broadinstitute.org/gsea/msigdb/cards/TGANTCA_V$AP1_C M13826 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 20.2685150274333 N 1.0 13-AUG-20 MSigDB A 13229
FAX000348 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGAYRTCA which matches annotation for ATF3: activating transcription factor 3 496 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGAYRTCA which matches annotation for ATF3: activating transcription factor 3 http://www.broadinstitute.org/gsea/msigdb/cards/TGAYRTCA_V$ATF3_Q6 M9955 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.562558108472 N 1.0 13-AUG-20 MSigDB A 13229
FAX000366 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif TTTNNANAGCYR. Motif does not match any known transcription factor 83 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif TTTNNANAGCYR. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/TTTNNANAGCYR_UNKNOWN M15966 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 65.8534779816637 N 1.0 13-AUG-20 MSigDB A 13229
FAX000371 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTNGCGTGNNN which matches annotation for AHR: aryl hydrocarbon receptor 198 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTNGCGTGNNN which matches annotation for AHR: aryl hydrocarbon receptor http://www.broadinstitute.org/gsea/msigdb/cards/V$AHR_Q5 M17378 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 6.65446742117765 N 1.0 13-AUG-20 MSigDB A 13229
FAX000374 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CKGDYTAAAAATAACYMM. Motif does not match any known transcription factor 237 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CKGDYTAAAAATAACYMM. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$AMEF2_Q6 M3489 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.48997524032034 N 1.0 13-AUG-20 MSigDB A 13229
FAX000378 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RSTGACTNMNW which matches annotation for JUN: jun oncogene 253 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RSTGACTNMNW which matches annotation for JUN: jun oncogene http://www.broadinstitute.org/gsea/msigdb/cards/V$AP1FJ_Q2 M16919 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 23.4495471810624 N 1.0 13-AUG-20 MSigDB A 13229
FAX000381 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RSTGACTNANW which matches annotation for JUN: jun oncogene 247 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RSTGACTNANW which matches annotation for JUN: jun oncogene http://www.broadinstitute.org/gsea/msigdb/cards/V$AP1_Q2 M9376 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 17.9975091721192 N 1.0 13-AUG-20 MSigDB A 13229
FAX000384 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGAGTCAN which matches annotation for JUN: jun oncogene 240 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGAGTCAN which matches annotation for JUN: jun oncogene http://www.broadinstitute.org/gsea/msigdb/cards/V$AP1_Q4_01 M12460 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 7.95501142114287 N 1.0 13-AUG-20 MSigDB A 13229
FAX000387 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GCCNNNRGS which matches annotation for TFAP2A: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 222 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GCCNNNRGS which matches annotation for TFAP2A: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) http://www.broadinstitute.org/gsea/msigdb/cards/V$AP2ALPHA_01 M18732 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 9.24073212082368 N 1.0 13-AUG-20 MSigDB A 13229
FAX000391 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif MKCCCSCNGGCG which matches annotation for GTF3A: general transcription factor IIIA 243 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif MKCCCSCNGGCG which matches annotation for GTF3A: general transcription factor IIIA http://www.broadinstitute.org/gsea/msigdb/cards/V$AP2_Q6 M18558 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.10923006018341 N 1.0 13-AUG-20 MSigDB A 13229
FAX000399 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif WNWCACCTGWNN which matches annotation for TCF8: transcription factor 8 (represses interleukin 2 expression) 238 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif WNWCACCTGWNN which matches annotation for TCF8: transcription factor 8 (represses interleukin 2 expression) http://www.broadinstitute.org/gsea/msigdb/cards/V$AREB6_02 M6885 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 3.91401354718881 N 1.0 13-AUG-20 MSigDB A 13229
FAX000405 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGTACANNRTGTTCT which matches annotation for AR: androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) 141 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGTACANNRTGTTCT which matches annotation for AR: androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) http://www.broadinstitute.org/gsea/msigdb/cards/V$AR_01 M16670 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.326876513317191 N 1.0 13-AUG-20 MSigDB A 13229
FAX000407 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNNRGNACRNNGTGTTCTNNNNNN which matches annotation for AR: androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) 52 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNNRGNACRNNGTGTTCTNNNNNN which matches annotation for AR: androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) http://www.broadinstitute.org/gsea/msigdb/cards/V$AR_03 M2274 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.0 N 1.0 13-AUG-20 MSigDB A 13229
FAX000414 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CNSTGACGTNNNYC. Motif does not match any known transcription factor 242 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CNSTGACGTNNNYC. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$ATF_01 M16213 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 9.63430578424931 N 1.0 13-AUG-20 MSigDB A 13229
FAX000417 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SRTGAGTCANC which matches annotation for BACH2: BTB and CNC homology 1, basic leucine zipper transcription factor 2 251 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SRTGAGTCANC which matches annotation for BACH2: BTB and CNC homology 1, basic leucine zipper transcription factor 2 http://www.broadinstitute.org/gsea/msigdb/cards/V$BACH2_01 M13237 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 13.9637419781881 N 1.0 13-AUG-20 MSigDB A 13229
FAX000421 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNTAATTNNCATTANCN which matches annotation for CART1: cartilage paired-class homeoprotein 1 204 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNTAATTNNCATTANCN which matches annotation for CART1: cartilage paired-class homeoprotein 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$CART1_01 M15595 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.03834921661736 N 1.0 13-AUG-20 MSigDB A 13229
FAX000424 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NATYGATSSS which matches annotation for CUTL1: cut-like 1, CCAAT displacement protein (Drosophila) 214 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NATYGATSSS which matches annotation for CUTL1: cut-like 1, CCAAT displacement protein (Drosophila) http://www.broadinstitute.org/gsea/msigdb/cards/V$CDPCR3HD_01 M15128 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.26060431014624 N 1.0 13-AUG-20 MSigDB A 13229
FAX000427 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NWNATCGATTANYNN which matches annotation for CUTL1: cut-like 1, CCAAT displacement protein (Drosophila) 99 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NWNATCGATTANYNN which matches annotation for CUTL1: cut-like 1, CCAAT displacement protein (Drosophila) http://www.broadinstitute.org/gsea/msigdb/cards/V$CDP_02 M2852 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.92127034172672 N 1.0 13-AUG-20 MSigDB A 13229
FAX000434 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNTKTGGWNANNN which matches annotation for CEBPA: CCAAT/enhancer binding protein (C/EBP), alpha 247 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNTKTGGWNANNN which matches annotation for CEBPA: CCAAT/enhancer binding protein (C/EBP), alpha http://www.broadinstitute.org/gsea/msigdb/cards/V$CEBP_01 M8695 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.86491090384515 N 1.0 13-AUG-20 MSigDB A 13229
FAX000437 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTTRCNNAANNN which matches annotation for CEBPA: CCAAT/enhancer binding protein (C/EBP), alpha 252 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTTRCNNAANNN which matches annotation for CEBPA: CCAAT/enhancer binding protein (C/EBP), alpha http://www.broadinstitute.org/gsea/msigdb/cards/V$CEBP_Q2_01 M6830 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 12.7515464855538 N 1.0 13-AUG-20 MSigDB A 13229
FAX000440 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNRTGCAATMCCC which matches annotation for DDIT3: DNA-damage-inducible transcript 3
CEBPA DIFF GENES 216 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNRTGCAATMCCC which matches annotation for DDIT3: DNA-damage-inducible transcript 3
CEBPA DIFF GENES http://www.broadinstitute.org/gsea/msigdb/cards/V$CHOP_01 M9852 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.61184822610845 N 1.0 13-AUG-20 MSigDB A 13229
FAX000532 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CARGKTSAWTRACC which matches annotation for NR1H4: nuclear receptor subfamily 1, group H, member 4 106 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CARGKTSAWTRACC which matches annotation for NR1H4: nuclear receptor subfamily 1, group H, member 4 http://www.broadinstitute.org/gsea/msigdb/cards/V$FXR_Q3 M9731 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.31434571466072 N 1.0 13-AUG-20 MSigDB A 13229
FAX000451 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTACGTAA which matches annotation for ATF2: activating transcription factor 2 167 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTACGTAA which matches annotation for ATF2: activating transcription factor 2 http://www.broadinstitute.org/gsea/msigdb/cards/V$CREBP1_01 M15359 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.6872136869706 N 1.0 13-AUG-20 MSigDB A 13229
FAX000454 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNGNTGACGTNN which matches annotation for CREB1: cAMP responsive element binding protein 1 227 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNGNTGACGTNN which matches annotation for CREB1: cAMP responsive element binding protein 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$CREB_02 M6342 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 3.94257289492288 N 1.0 13-AUG-20 MSigDB A 13229
FAX000457 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CGTCAN which matches annotation for CREB1: cAMP responsive element binding protein 1 226 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CGTCAN which matches annotation for CREB1: cAMP responsive element binding protein 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$CREB_Q3 M14786 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.18859915519597 N 1.0 13-AUG-20 MSigDB A 13229
FAX000460 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SGGRNTTTCC which matches annotation for REL: v-rel reticuloendotheliosis viral oncogene homolog (avian) 249 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SGGRNTTTCC which matches annotation for REL: v-rel reticuloendotheliosis viral oncogene homolog (avian) http://www.broadinstitute.org/gsea/msigdb/cards/V$CREL_01 M10143 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 27.1884356607294 N 1.0 13-AUG-20 MSigDB A 13229
FAX000466 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RRCAGGTGNCV which matches annotation for TCF3: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 247 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RRCAGGTGNCV which matches annotation for TCF3: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) http://www.broadinstitute.org/gsea/msigdb/cards/V$E12_Q6 M15183 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 3.85951205035437 N 1.0 13-AUG-20 MSigDB A 13229
FAX000469 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F1: E2F transcription factor 1
TFDP1: transcription factor Dp-1 215 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F1: E2F transcription factor 1
TFDP1: transcription factor Dp-1 http://www.broadinstitute.org/gsea/msigdb/cards/V$E2F1DP1_01 M12402 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 355.517505070569 N 1.0 13-AUG-20 MSigDB A 13229
FAX000472 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTGGCGCGRAANNGNM which matches annotation for E2F1: E2F transcription factor 1 232 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTGGCGCGRAANNGNM which matches annotation for E2F1: E2F transcription factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$E2F1_Q3_01 M17736 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 19.7365579322625 N 1.0 13-AUG-20 MSigDB A 13229
FAX000476 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTTTCGCGCS which matches annotation for E2F1: E2F transcription factor 1 221 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTTTCGCGCS which matches annotation for E2F1: E2F transcription factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$E2F1_Q6_01 M3037 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 274.996925090752 N 1.0 13-AUG-20 MSigDB A 13229
FAX000478 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F4: E2F transcription factor 4, p107/p130-binding
TFDP2: transcription factor Dp-2 (E2F dimerization partner 2) 215 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTTCSCGC which matches annotation for E2F4: E2F transcription factor 4, p107/p130-binding
TFDP2: transcription factor Dp-2 (E2F dimerization partner 2) http://www.broadinstitute.org/gsea/msigdb/cards/V$E2F4DP2_01 M19298 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 355.517505070569 N 1.0 13-AUG-20 MSigDB A 13229
FAX000486 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NCSCGCSAAAN which matches annotation for E2F
TFDP1: transcription factor Dp-1 216 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NCSCGCSAAAN which matches annotation for E2F
TFDP1: transcription factor Dp-1 http://www.broadinstitute.org/gsea/msigdb/cards/V$E2F_Q4_01 M102 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 395.221264774183 N 1.0 13-AUG-20 MSigDB A 13229
FAX000489 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif VSNGCAGGTGKNCNN which matches annotation for TCF3: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 238 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif VSNGCAGGTGKNCNN which matches annotation for TCF3: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) http://www.broadinstitute.org/gsea/msigdb/cards/V$E47_01 M5067 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 9.74555026877042 N 1.0 13-AUG-20 MSigDB A 13229
FAX000493 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif MGTTACYAGGCAAM which matches annotation for RFX1: regulatory factor X, 1 (influences HLA class II expression) 249 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif MGTTACYAGGCAAM which matches annotation for RFX1: regulatory factor X, 1 (influences HLA class II expression) http://www.broadinstitute.org/gsea/msigdb/cards/V$EFC_Q6 M1181 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.12061726015048 N 1.0 13-AUG-20 MSigDB A 13229
FAX000496 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTGCGTGGGCGK which matches annotation for EGR3: early growth response 3 80 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTGCGTGGGCGK which matches annotation for EGR3: early growth response 3 http://www.broadinstitute.org/gsea/msigdb/cards/V$EGR3_01 M545 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 3.73046613544568 N 1.0 13-AUG-20 MSigDB A 13229
FAX000498 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RNWMBAGGAART which matches annotation for ELF1: E74-like factor 1 (ets domain transcription factor) 226 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RNWMBAGGAART which matches annotation for ELF1: E74-like factor 1 (ets domain transcription factor) http://www.broadinstitute.org/gsea/msigdb/cards/V$ELF1_Q6 M9902 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 22.9364866166762 N 1.0 13-AUG-20 MSigDB A 13229
FAX000504 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif KDMAYYNTGACCT which matches annotation for AR: androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) 241 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif KDMAYYNTGACCT which matches annotation for AR: androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) http://www.broadinstitute.org/gsea/msigdb/cards/V$ER_Q6_01 M19434 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.30531488160938 N 1.0 13-AUG-20 MSigDB A 13229
FAX000508 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif KRCAGGAARTRNKT which matches annotation for ETS2: v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 264 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif KRCAGGAARTRNKT which matches annotation for ETS2: v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) http://www.broadinstitute.org/gsea/msigdb/cards/V$ETS2_B M3956 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 11.3396096637586 N 1.0 13-AUG-20 MSigDB A 13229
FAX000511 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AGAYAAGATAA which matches annotation for EVI1: ecotropic viral integration site 1 116 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AGAYAAGATAA which matches annotation for EVI1: ecotropic viral integration site 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$EVI1_02 M1855 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.48792241454594 N 1.0 13-AUG-20 MSigDB A 13229
FAX000514 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AGATAAGATAN which matches annotation for EVI1: ecotropic viral integration site 1 160 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AGATAAGATAN which matches annotation for EVI1: ecotropic viral integration site 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$EVI1_05 M12043 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.730660342701563 N 1.0 13-AUG-20 MSigDB A 13229
FAX000522 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GNNTTGTTTACNTT which matches annotation for FOXO1A: forkhead box O1A (rhabdomyosarcoma) 226 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GNNTTGTTTACNTT which matches annotation for FOXO1A: forkhead box O1A (rhabdomyosarcoma) http://www.broadinstitute.org/gsea/msigdb/cards/V$FOXO1_02 M4774 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 6.31814636272004 N 1.0 13-AUG-20 MSigDB A 13229
FAX000525 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNGTTGTTTACNTN which matches annotation for MLLT7: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 239 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNGTTGTTTACNTN which matches annotation for MLLT7: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 http://www.broadinstitute.org/gsea/msigdb/cards/V$FOXO4_02 M16417 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.03054844280355 N 1.0 13-AUG-20 MSigDB A 13229
FAX000529 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CTWAWGTAAACANWGN which matches annotation for FOXD1: forkhead box D1 141 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CTWAWGTAAACANWGN which matches annotation for FOXD1: forkhead box D1 http://www.broadinstitute.org/gsea/msigdb/cards/V$FREAC4_01 M14649 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.23086282064281 N 1.0 13-AUG-20 MSigDB A 13229
WIG001922 IL-7 signaling pathway 25 Homo sapiens IL-7 signaling pathway http://www.wikipathways.org/index.php/Pathway:WP205 PAGER curation team PAGER-contact@googlegroups.com A.Pandey, MaintBot, Khanspers, MartijnVanIersel, AlexanderPico CURRENT 4721.70170393503 N 1.0 13-AUG-20 WikiPathway P 144
WIG001988 Cytoplasmic Ribosomal Proteins 89 Homo sapiens Cytoplasmic Ribosomal Proteins http://www.wikipathways.org/index.php/Pathway:WP477 PAGER curation team PAGER-contact@googlegroups.com Kdahlquist, MaintBot, MartijnVanIersel, Khanspers CURRENT 42935.2239110943 N 1.0 13-AUG-20 WikiPathway P 144
WIG001996 Hypertrophy Model 19 Homo sapiens Hypertrophy Model http://www.wikipathways.org/index.php/Pathway:WP516 PAGER curation team PAGER-contact@googlegroups.com A.C.Zambon, MaintBot, Derob, Thomas, Khanspers, AlexanderPico CURRENT 177.131248280684 N 1.0 13-AUG-20 WikiPathway P 144
WIG002021 TCR Signaling Pathway 88 Homo sapiens TCR Signaling Pathway http://www.wikipathways.org/index.php/Pathway:WP69 PAGER curation team PAGER-contact@googlegroups.com A.Pandey, MaintBot, Thomas, Khanspers CURRENT 3857.79844053774 N 1.0 13-AUG-20 WikiPathway P 144
WIG002030 metapathway biotransformation 174 Homo sapiens metapathway biotransformation http://www.wikipathways.org/index.php/Pathway:WP702 PAGER curation team PAGER-contact@googlegroups.com Pieter Giesbertz, Khanspers, MaintBot, MartijnVanIersel CURRENT 1802.86856733812 N 1.0 13-AUG-20 WikiPathway P 144
GEX000664 exercise (leisure time) 1 Homo sapiens exercise (leisure time) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
FAX000538 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NCWGATAACA which matches annotation for GATA1: GATA binding protein 1 (globin transcription factor 1) 265 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NCWGATAACA which matches annotation for GATA1: GATA binding protein 1 (globin transcription factor 1) http://www.broadinstitute.org/gsea/msigdb/cards/V$GATA1_05 M2958 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 9.25286152860261 N 1.0 13-AUG-20 MSigDB A 13229
FAX000542 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNGATWANN which matches annotation for GATA6: GATA binding protein 6 249 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNGATWANN which matches annotation for GATA6: GATA binding protein 6 http://www.broadinstitute.org/gsea/msigdb/cards/V$GATA6_01 M13052 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.22038766207004 N 1.0 13-AUG-20 MSigDB A 13229
FAX000545 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CNNRCCCGCATD which matches annotation for GCM1: glial cells missing homolog 1 (Drosophila) 224 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CNNRCCCGCATD which matches annotation for GCM1: glial cells missing homolog 1 (Drosophila) http://www.broadinstitute.org/gsea/msigdb/cards/V$GCM_Q2 M955 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 3.9641673999544 N 1.0 13-AUG-20 MSigDB A 13229
FAX000548 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGTACAANNTGTYCTK which matches annotation for NR3C1: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 118 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGTACAANNTGTYCTK which matches annotation for NR3C1: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) http://www.broadinstitute.org/gsea/msigdb/cards/V$GRE_C M13457 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.745259089261988 N 1.0 13-AUG-20 MSigDB A 13229
FAX000550 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNNCNNTNTGTNCTNN which matches annotation for NR3C1: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 247 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNNCNNTNTGTNCTNN which matches annotation for NR3C1: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) http://www.broadinstitute.org/gsea/msigdb/cards/V$GR_Q6 M7038 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.07294526303995 N 1.0 13-AUG-20 MSigDB A 13229
FAX000557 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif KNNTRTTTRTTTA which matches annotation for FOXI1: forkhead box I1 175 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif KNNTRTTTRTTTA which matches annotation for FOXI1: forkhead box I1 http://www.broadinstitute.org/gsea/msigdb/cards/V$HFH3_01 M13641 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.75360012729732 N 1.0 13-AUG-20 MSigDB A 13229
FAX000560 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GNNKACGTGCGGNN which matches annotation for HIF1A: hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 209 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GNNKACGTGCGGNN which matches annotation for HIF1A: hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) http://www.broadinstitute.org/gsea/msigdb/cards/V$HIF1_Q3 M14011 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.95670396699157 N 1.0 13-AUG-20 MSigDB A 13229
FAX000564 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGAAAWT which matches annotation for HMGA1: high mobility group AT-hook 1 235 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGAAAWT which matches annotation for HMGA1: high mobility group AT-hook 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$HMGIY_Q6 M19147 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 3.19578506263534 N 1.0 13-AUG-20 MSigDB A 13229
FAX000567 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif DGTTAATKAWTNACCAM which matches annotation for TCF1: transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor 227 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif DGTTAATKAWTNACCAM which matches annotation for TCF1: transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor http://www.broadinstitute.org/gsea/msigdb/cards/V$HNF1_C M14593 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.27582154568133 N 1.0 13-AUG-20 MSigDB A 13229
FAX000570 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif KGNANTRTTTRYTTW which matches annotation for FOXA2: forkhead box A2 199 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif KGNANTRTTTRYTTW which matches annotation for FOXA2: forkhead box A2 http://www.broadinstitute.org/gsea/msigdb/cards/V$HNF3B_01 M6136 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.15162554127431 N 1.0 13-AUG-20 MSigDB A 13229
FAX000443 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NCNRNNGRCNGTTGGKGG which matches annotation for MYB: v-myb myeloblastosis viral oncogene homolog (avian) 228 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NCNRNNGRCNGTTGGKGG which matches annotation for MYB: v-myb myeloblastosis viral oncogene homolog (avian) http://www.broadinstitute.org/gsea/msigdb/cards/V$CMYB_01 M10817 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 9.08231612344061 N 1.0 13-AUG-20 MSigDB A 13229
FAX000448 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GCHCDAMCCAG which matches annotation for TFCP2: transcription factor CP2 249 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GCHCDAMCCAG which matches annotation for TFCP2: transcription factor CP2 http://www.broadinstitute.org/gsea/msigdb/cards/V$CP2_01 M17000 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 7.140590006235 N 1.0 13-AUG-20 MSigDB A 13229
FAX000731 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AGACNBCNN which matches annotation for SMAD1: SMAD, mothers against DPP homolog 1 (Drosophila) 232 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AGACNBCNN which matches annotation for SMAD1: SMAD, mothers against DPP homolog 1 (Drosophila) http://www.broadinstitute.org/gsea/msigdb/cards/V$SMAD_Q6 M1903 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 6.97828167163783 N 1.0 13-AUG-20 MSigDB A 13229
FAX000737 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NGGGGGCGGGGYN which matches annotation for SP1: Sp1 transcription factor 237 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NGGGGGCGGGGYN which matches annotation for SP1: Sp1 transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$SP1_Q6 M9525 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 11.5699946700844 N 1.0 13-AUG-20 MSigDB A 13229
FAX000740 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif DNNGGRGGGWWNNNN which matches annotation for SPZ1: spermatogenic leucine zipper 1 218 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif DNNGGRGGGWWNNNN which matches annotation for SPZ1: spermatogenic leucine zipper 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$SPZ1_01 M17319 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 23.7050809748386 N 1.0 13-AUG-20 MSigDB A 13229
FAX000743 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CACSCCA which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1 231 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CACSCCA which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$SREBP1_Q6 M19265 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.87268853637726 N 1.0 13-AUG-20 MSigDB A 13229
GEX001357 primary hyperparathyroidism 3 Homo sapiens primary hyperparathyroidism associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
TAX034454 GO:2000057 biological_process negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis 1 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000057 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034455 GO:2000058 biological_process regulation of ubiquitin-dependent protein catabolic process 154 Homo sapiens Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000058 PAGER curation team PAGER-contact@googlegroups.com 189.325820665731 2 13-AUG-20 GOA A 21894
TAX034456 GO:2000059 biological_process negative regulation of ubiquitin-dependent protein catabolic process 47 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000059 PAGER curation team PAGER-contact@googlegroups.com 51.0935068491291 2 13-AUG-20 GOA A 21894
TAX034457 GO:2000060 biological_process positive regulation of ubiquitin-dependent protein catabolic process 101 Homo sapiens Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000060 PAGER curation team PAGER-contact@googlegroups.com 130.671450114147 2 13-AUG-20 GOA A 21894
TAX034458 GO:2000061 biological_process regulation of ureter smooth muscle cell differentiation 1 Homo sapiens Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000061 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034459 GO:2000062 biological_process negative regulation of ureter smooth muscle cell differentiation 1 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000062 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034460 GO:2000063 biological_process positive regulation of ureter smooth muscle cell differentiation 1 Homo sapiens Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000063 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034461 GO:2000064 biological_process regulation of cortisol biosynthetic process 6 Homo sapiens Any process that modulates the frequency, rate or extent of cortisol biosynthetic process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000064 PAGER curation team PAGER-contact@googlegroups.com 17.1866295264624 2 13-AUG-20 GOA A 21894
TAX034462 GO:2000065 biological_process negative regulation of cortisol biosynthetic process 4 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000065 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX034463 GO:2000066 biological_process positive regulation of cortisol biosynthetic process 1 Homo sapiens Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000066 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034464 GO:2000067 biological_process regulation of root morphogenesis 1 Homo sapiens Any process that modulates the frequency, rate or extent of root morphogenesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000067 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034465 GO:2000074 biological_process regulation of type B pancreatic cell development 8 Homo sapiens Any process that modulates the frequency, rate or extent of pancreatic B cell development. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000074 PAGER curation team PAGER-contact@googlegroups.com 22.9022403258656 2 13-AUG-20 GOA A 21894
TAX034466 GO:2000077 biological_process negative regulation of type B pancreatic cell development 2 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000077 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX034467 GO:2000078 biological_process positive regulation of type B pancreatic cell development 3 Homo sapiens Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000078 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034468 GO:2000079 biological_process regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation 2 Homo sapiens Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000079 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX034469 GO:2000080 biological_process negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation 1 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000080 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034470 GO:2000081 biological_process positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation 1 Homo sapiens Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000081 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX034471 GO:2000095 biological_process regulation of Wnt signaling pathway, planar cell polarity pathway 14 Homo sapiens Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000095 PAGER curation team PAGER-contact@googlegroups.com 18.5231116121759 2 13-AUG-20 GOA A 21894
TAX034472 GO:2000096 biological_process positive regulation of Wnt signaling pathway, planar cell polarity pathway 8 Homo sapiens Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000096 PAGER curation team PAGER-contact@googlegroups.com 9.91853360488798 2 13-AUG-20 GOA A 21894
TAX034473 GO:2000097 biological_process regulation of smooth muscle cell-matrix adhesion 3 Homo sapiens Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion. http://amigo.geneontology.org/amigo/search/ontology?q=GO:2000097 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
FAX000756 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNTTCCN which matches annotation for STAT3: signal transducer and activator of transcription 3 (acute-phase response factor) 137 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNTTCCN which matches annotation for STAT3: signal transducer and activator of transcription 3 (acute-phase response factor) http://www.broadinstitute.org/gsea/msigdb/cards/V$STAT3_02 M3263 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.13437573684414 N 1.0 13-AUG-20 MSigDB A 13229
FAX000759 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTCCNRGAANNNNNNTTCCNNGRR which matches annotation for STAT5A: signal transducer and activator of transcription 5A 132 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTCCNRGAANNNNNNTTCCNNGRR which matches annotation for STAT5A: signal transducer and activator of transcription 5A http://www.broadinstitute.org/gsea/msigdb/cards/V$STAT5A_02 M18386 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.64472186458054 N 1.0 13-AUG-20 MSigDB A 13229
FAX000762 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NAWTTCYNGGAAWTN which matches annotation for STAT5B: signal transducer and activator of transcription 5B 225 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NAWTTCYNGGAAWTN which matches annotation for STAT5B: signal transducer and activator of transcription 5B http://www.broadinstitute.org/gsea/msigdb/cards/V$STAT5B_01 M6144 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 14.5818184167917 N 1.0 13-AUG-20 MSigDB A 13229
FAX000766 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NNNNNTTCTKGGA. Motif does not match any known transcription factor 242 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NNNNNTTCTKGGA. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$STAT_Q6 M3437 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.49272907784851 N 1.0 13-AUG-20 MSigDB A 13229
FAX000773 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif GGGGGTTGACGYANA. Motif does not match any known transcription factor 128 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif GGGGGTTGACGYANA. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$TAXCREB_01 M5608 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 7.45589107252548 N 1.0 13-AUG-20 MSigDB A 13229
FAX000776 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNATGACTCAGCANTTNNG which matches annotation for TCF11
MAFG: v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 195 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNATGACTCAGCANTTNNG which matches annotation for TCF11
MAFG: v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) http://www.broadinstitute.org/gsea/msigdb/cards/V$TCF11MAFG_01 M4121 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 10.5387727021255 N 1.0 13-AUG-20 MSigDB A 13229
FAX000779 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SCTTTGAW which matches annotation for TCF4: transcription factor 4 217 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SCTTTGAW which matches annotation for TCF4: transcription factor 4 http://www.broadinstitute.org/gsea/msigdb/cards/V$TCF4_Q5 M1224 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.01139971974765 N 1.0 13-AUG-20 MSigDB A 13229
FAX000782 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif YTACTTCCTG which matches annotation for ETV7: ets variant gene 7 (TEL2 oncogene) 221 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif YTACTTCCTG which matches annotation for ETV7: ets variant gene 7 (TEL2 oncogene) http://www.broadinstitute.org/gsea/msigdb/cards/V$TEL2_Q6 M5155 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 12.658495431103 N 1.0 13-AUG-20 MSigDB A 13229
FAX000789 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CASGYG. Motif does not match any known transcription factor 236 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CASGYG. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$USF2_Q6 M17508 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 6.07900675393415 N 1.0 13-AUG-20 MSigDB A 13229
FAX000795 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGGKNARNRRGGWSA which matches annotation for VDR: vitamin D (1,25- dihydroxyvitamin D3) receptor 209 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGGKNARNRRGGWSA which matches annotation for VDR: vitamin D (1,25- dihydroxyvitamin D3) receptor http://www.broadinstitute.org/gsea/msigdb/cards/V$VDR_Q3 M14782 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 11.033486403118 N 1.0 13-AUG-20 MSigDB A 13229
FAX000799 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNCCATNTWNNNWN which matches annotation for YY1: YY1 transcription factor 228 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNCCATNTWNNNWN which matches annotation for YY1: YY1 transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$YY1_01 M1517 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 10.7295035596301 N 1.0 13-AUG-20 MSigDB A 13229
FAX000802 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GSGCGCGR which matches annotation for ZFP161: zinc finger protein 161 homolog (mouse) 224 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GSGCGCGR which matches annotation for ZFP161: zinc finger protein 161 homolog (mouse) http://www.broadinstitute.org/gsea/msigdb/cards/V$ZF5_01 M1793 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 9.40506989664057 N 1.0 13-AUG-20 MSigDB A 13229
WIG001446 Chks in Checkpoint Regulation 51 Homo sapiens Chks in Checkpoint Regulation http://www.proteinlounge.com/pathway/Chks in Checkpoint Regulation PAGER curation team PAGER-contact@googlegroups.com CURRENT 2029.08876881341 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001452 Cleavage and Polyadenylation of Pre-mRNA 11 Homo sapiens Cleavage and Polyadenylation of Pre-mRNA http://www.proteinlounge.com/pathway/Cleavage and Polyadenylation of Pre-mRNA PAGER curation team PAGER-contact@googlegroups.com CURRENT 695.485965351396 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001482 Epithelial Adherens Junctions 249 Homo sapiens Epithelial Adherens Junctions http://www.proteinlounge.com/pathway/Epithelial Adherens Junctions PAGER curation team PAGER-contact@googlegroups.com CURRENT 137.086825682909 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001491 Agrin Interaction at Neuromuscular Junction 49 Homo sapiens Agrin Interaction at Neuromuscular Junction http://www.proteinlounge.com/pathway/Agrin Interaction at Neuromuscular Junction PAGER curation team PAGER-contact@googlegroups.com CURRENT 394.398404858455 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001500 Fc-GammaR Pathway 38 Homo sapiens Fc-GammaR Pathway http://www.proteinlounge.com/pathway/Fc-GammaR Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 219.381685592728 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001507 14-3-3 and Regulation of BAD Activity 27 Homo sapiens 14-3-3 and Regulation of BAD Activity http://www.proteinlounge.com/pathway/14-3-3 and Regulation of BAD Activity PAGER curation team PAGER-contact@googlegroups.com CURRENT 272.386948826353 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001533 Growth Hormone Signaling 55 Homo sapiens Growth Hormone Signaling http://www.proteinlounge.com/pathway/Growth Hormone Signaling PAGER curation team PAGER-contact@googlegroups.com CURRENT 382.177617684649 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001540 Hedgehog Signaling in Mammals 74 Homo sapiens Hedgehog Signaling in Mammals http://www.proteinlounge.com/pathway/Hedgehog Signaling in Mammals PAGER curation team PAGER-contact@googlegroups.com CURRENT 906.292706081758 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001549 HTLV1 Replication Cycle 4 Homo sapiens HTLV1 Replication Cycle http://www.proteinlounge.com/pathway/HTLV1 Replication Cycle PAGER curation team PAGER-contact@googlegroups.com CURRENT 151.800928775248 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001574 Intracellular Calcium Signaling 294 Homo sapiens Intracellular Calcium Signaling http://www.proteinlounge.com/pathway/Intracellular Calcium Signaling PAGER curation team PAGER-contact@googlegroups.com CURRENT 110.776897180859 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001582 Neuropathic Pain - Signaling in Dorsal Horn Neurons 43 Homo sapiens Neuropathic Pain - Signaling in Dorsal Horn Neurons http://www.proteinlounge.com/pathway/Neuropathic Pain - Signaling in Dorsal Horn Neurons PAGER curation team PAGER-contact@googlegroups.com CURRENT 486.246712756075 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001592 NK1R-mediated Non-Apoptotic PCD 4 Homo sapiens NK1R-mediated Non-Apoptotic PCD http://www.proteinlounge.com/pathway/NK1R-mediated Non-Apoptotic PCD PAGER curation team PAGER-contact@googlegroups.com CURRENT 49.0179485014931 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001623 PGC1Alpha Pathway 116 Homo sapiens PGC1Alpha Pathway http://www.proteinlounge.com/pathway/PGC1Alpha Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 169.163834876239 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001630 PKC-Theta Pathway 64 Homo sapiens PKC-Theta Pathway http://www.proteinlounge.com/pathway/PKC-Theta Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 201.400978583836 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001667 Salvage Pathway from Serine to Phosphatidylcholine 9 4 Homo sapiens Salvage Pathway from Serine to Phosphatidylcholine 9 http://www.proteinlounge.com/pathway/Salvage Pathway from Serine to Phosphatidylcholine 9 PAGER curation team PAGER-contact@googlegroups.com CURRENT 17.1866295264624 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001676 siRNA Pathway in Nematode and Mammal 4 Homo sapiens siRNA Pathway in Nematode and Mammal http://www.proteinlounge.com/pathway/siRNA Pathway in Nematode and Mammal PAGER curation team PAGER-contact@googlegroups.com CURRENT 5.1088534107402 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001684 Synthesis of Cardiolipin and Phosphatidylinositol 1 Homo sapiens Synthesis of Cardiolipin and Phosphatidylinositol http://www.proteinlounge.com/pathway/Synthesis of Cardiolipin and Phosphatidylinositol PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001715 Tumoricidal Effects of Hepatic NK Cells 19 Homo sapiens Tumoricidal Effects of Hepatic NK Cells http://www.proteinlounge.com/pathway/Tumoricidal Effects of Hepatic NK Cells PAGER curation team PAGER-contact@googlegroups.com CURRENT 409.326518225368 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001723 Virus-Induced Airway Inflammation 7 Homo sapiens Virus-Induced Airway Inflammation http://www.proteinlounge.com/pathway/Virus-Induced Airway Inflammation PAGER curation team PAGER-contact@googlegroups.com CURRENT 183.181808512901 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001730 Macrophage Differentiation and Growth Inhibition by METS 25 Homo sapiens Macrophage Differentiation and Growth Inhibition by METS http://www.proteinlounge.com/pathway/Macrophage Differentiation and Growth Inhibition by METS PAGER curation team PAGER-contact@googlegroups.com CURRENT 974.468663542322 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001751 MODY (Maturity-Onset Diabetes of Young) 9 Homo sapiens MODY (Maturity-Onset Diabetes of Young) http://www.proteinlounge.com/pathway/MODY (Maturity-Onset Diabetes of Young) PAGER curation team PAGER-contact@googlegroups.com CURRENT 48.0965639470909 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001758 Muscular Dystrophies and Dystrophin-Glycoprotein Complex 3 Homo sapiens Muscular Dystrophies and Dystrophin-Glycoprotein Complex http://www.proteinlounge.com/pathway/Muscular Dystrophies and Dystrophin-Glycoprotein Complex PAGER curation team PAGER-contact@googlegroups.com CURRENT 53.7883959044369 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001767 LT-BetaR Pathway 28 Homo sapiens LT-BetaR Pathway http://www.proteinlounge.com/pathway/LT-BetaR Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 357.880970131113 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001913 miRs in Muscle Cell Differentiation 29 Homo sapiens miRs in Muscle Cell Differentiation http://www.wikipathways.org/index.php/Pathway:WP2012 PAGER curation team PAGER-contact@googlegroups.com Samuel Sklar, Khanspers, MartijnVanIersel CURRENT 724.417303084134 N 1.0 13-AUG-20 WikiPathway P 144
TAX023858 GO:0042475 biological_process odontogenesis of dentin-containing tooth 68 Homo sapiens The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042475 PAGER curation team PAGER-contact@googlegroups.com 228.357081588449 2 13-AUG-20 GOA A 21894
TAX023859 GO:0042476 biological_process odontogenesis 97 Homo sapiens The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042476 PAGER curation team PAGER-contact@googlegroups.com 206.636748547621 2 13-AUG-20 GOA A 21894
TAX023860 GO:0042478 biological_process regulation of eye photoreceptor cell development 2 Homo sapiens Any process that modulates the frequency, rate or extent of eye photoreceptor development. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042478 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023861 GO:0042480 biological_process negative regulation of eye photoreceptor cell development 2 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042480 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023862 GO:0042481 biological_process regulation of odontogenesis 26 Homo sapiens Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042481 PAGER curation team PAGER-contact@googlegroups.com 235.602266122262 2 13-AUG-20 GOA A 21894
TAX023864 GO:0042483 biological_process negative regulation of odontogenesis 4 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042483 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023865 GO:0042487 biological_process regulation of odontogenesis of dentin-containing tooth 14 Homo sapiens Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042487 PAGER curation team PAGER-contact@googlegroups.com 98.8813066546735 2 13-AUG-20 GOA A 21894
TAX023866 GO:0042488 biological_process positive regulation of odontogenesis of dentin-containing tooth 4 Homo sapiens Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042488 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX023867 GO:0042489 biological_process negative regulation of odontogenesis of dentin-containing tooth 2 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042489 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023868 GO:0042490 biological_process mechanoreceptor differentiation 12 Homo sapiens The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042490 PAGER curation team PAGER-contact@googlegroups.com 124.430521063282 2 13-AUG-20 GOA A 21894
TAX023869 GO:0042491 biological_process inner ear auditory receptor cell differentiation 4 Homo sapiens The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042491 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
GEX000694 fibrinogen myocardial infarct 2 Homo sapiens fibrinogen myocardial infarct associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001399 radiotherapy response 6 Homo sapiens radiotherapy response associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 328.886391772882 N 1.0 13-AUG-20 GAD G 1671
GEX001021 liver disease 7 Homo sapiens liver disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 48.1647058823529 N 1.0 13-AUG-20 GAD G 1671
GEX001084 melanoma 31 Homo sapiens melanoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 88.4994300345435 N 1.0 13-AUG-20 GAD G 1671
GEX001678 wilson disease 2 Homo sapiens wilson disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000759 graft-versus-host disease 11 Homo sapiens graft-versus-host disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 298.25891090042 N 1.0 13-AUG-20 GAD G 1671
WIG001542 HGF Pathway 52 Homo sapiens HGF Pathway http://www.proteinlounge.com/pathway/HGF Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 844.35295591649 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001594 nNOS Signaling in Skeletal Muscle 14 Homo sapiens nNOS Signaling in Skeletal Muscle http://www.proteinlounge.com/pathway/nNOS Signaling in Skeletal Muscle PAGER curation team PAGER-contact@googlegroups.com CURRENT 58.602481858939 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001631 PKR Pathway 45 Homo sapiens PKR Pathway http://www.proteinlounge.com/pathway/PKR Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 438.029187442165 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001962 Mitochondrial LC-Fatty Acid Beta-Oxidation 16 Homo sapiens Mitochondrial LC-Fatty Acid Beta-Oxidation http://www.wikipathways.org/index.php/Pathway:WP368 PAGER curation team PAGER-contact@googlegroups.com N.Reyes, MaintBot, Thomas, Khanspers, Jildau, MartijnVanIersel, AlexanderPico CURRENT 2010.45411692921 N 1.0 13-AUG-20 WikiPathway P 144
WIG002020 Catalytic cycle of mammalian FMOs 5 Homo sapiens Catalytic cycle of mammalian FMOs http://www.wikipathways.org/index.php/Pathway:WP688 PAGER curation team PAGER-contact@googlegroups.com Pieter Giesbertz, AlexanderPico, MaintBot, Khanspers, MartijnVanIersel CURRENT 882.508700274157 N 1.0 13-AUG-20 WikiPathway P 144
FAX000380 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTGASTCAG which matches annotation for JUN: jun oncogene 256 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTGASTCAG which matches annotation for JUN: jun oncogene http://www.broadinstitute.org/gsea/msigdb/cards/V$AP1_C M7937 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.0201147936008 N 1.0 13-AUG-20 MSigDB A 13229
FAX000599 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SWWCAAAGGG which matches annotation for LEF1: lymphoid enhancer-binding factor 1
TCF1: transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor 244 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SWWCAAAGGG which matches annotation for LEF1: lymphoid enhancer-binding factor 1
TCF1: transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor http://www.broadinstitute.org/gsea/msigdb/cards/V$LEF1_Q6 M14944 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.91742190727207 N 1.0 13-AUG-20 MSigDB A 13229
FAX000575 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGAMCTTTGNCCN which matches annotation for HNF4A: hepatocyte nuclear factor 4, alpha 242 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGAMCTTTGNCCN which matches annotation for HNF4A: hepatocyte nuclear factor 4, alpha http://www.broadinstitute.org/gsea/msigdb/cards/V$HNF4_DR1_Q3 M13332 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.84856594333585 N 1.0 13-AUG-20 MSigDB A 13229
FAX000668 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNGAATATKCANNNN which matches annotation for POU2F1: POU domain, class 2, transcription factor 1 202 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNGAATATKCANNNN which matches annotation for POU2F1: POU domain, class 2, transcription factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$OCT1_02 M7213 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 6.11924030842664 N 1.0 13-AUG-20 MSigDB A 13229
FAX000671 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif MKVATTTGCATATT which matches annotation for POU2F1: POU domain, class 2, transcription factor 1 230 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif MKVATTTGCATATT which matches annotation for POU2F1: POU domain, class 2, transcription factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$OCT1_05 M5708 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 7.56922690760798 N 1.0 13-AUG-20 MSigDB A 13229
FAX000674 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TATGCAAATN which matches annotation for POU2F1: POU domain, class 2, transcription factor 1 237 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TATGCAAATN which matches annotation for POU2F1: POU domain, class 2, transcription factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$OCT1_B M15558 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 6.37668045235895 N 1.0 13-AUG-20 MSigDB A 13229
FAX000684 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNGTCANGNRTKANNNN which matches annotation for PAX2: paired box gene 2 53 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNGTCANGNRTKANNNN which matches annotation for PAX2: paired box gene 2 http://www.broadinstitute.org/gsea/msigdb/cards/V$PAX2_01 M11949 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.863888156159325 N 1.0 13-AUG-20 MSigDB A 13229
FAX000687 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNNCGTCACGSTYNNNNN which matches annotation for PAX3: paired box gene 3 (Waardenburg syndrome 1) 86 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNNCGTCACGSTYNNNNN which matches annotation for PAX3: paired box gene 3 (Waardenburg syndrome 1) http://www.broadinstitute.org/gsea/msigdb/cards/V$PAX3_B M2034 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.95335933516248 N 1.0 13-AUG-20 MSigDB A 13229
FAX000691 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RAAAAWTANNNNNNNNNNNNNNNYCACNCC which matches annotation for PAX4: paired box gene 4 199 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RAAAAWTANNNNNNNNNNNNNNNYCACNCC which matches annotation for PAX4: paired box gene 4 http://www.broadinstitute.org/gsea/msigdb/cards/V$PAX4_04 M4215 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 3.8421600012891 N 1.0 13-AUG-20 MSigDB A 13229
FAX000693 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RRMSWGANWYCTNRAGCGKRACSRYNSM which matches annotation for PAX5: paired box gene 5 (B-cell lineage specific activator) 15 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RRMSWGANWYCTNRAGCGKRACSRYNSM which matches annotation for PAX5: paired box gene 5 (B-cell lineage specific activator) http://www.broadinstitute.org/gsea/msigdb/cards/V$PAX5_02 M18203 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.53917050691244 N 1.0 13-AUG-20 MSigDB A 13229
FAX000701 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NMTTCATAAWTATWNMNA which matches annotation for POU1F1: POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) 210 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NMTTCATAAWTATWNMNA which matches annotation for POU1F1: POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) http://www.broadinstitute.org/gsea/msigdb/cards/V$PIT1_Q6 M15591 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 3.90106468706705 N 1.0 13-AUG-20 MSigDB A 13229
FAX000704 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif ATGMATWWATTCAT which matches annotation for POU3F2: POU domain, class 3, transcription factor 2 98 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif ATGMATWWATTCAT which matches annotation for POU3F2: POU domain, class 3, transcription factor 2 http://www.broadinstitute.org/gsea/msigdb/cards/V$POU3F2_01 M3720 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.753466402559805 N 1.0 13-AUG-20 MSigDB A 13229
FAX000707 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CARAACTAGGNCAAAGGTCA which matches annotation for PPARA: peroxisome proliferative activated receptor, alpha 34 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CARAACTAGGNCAAAGGTCA which matches annotation for PPARA: peroxisome proliferative activated receptor, alpha http://www.broadinstitute.org/gsea/msigdb/cards/V$PPARA_01 M14641 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 11.1553136847254 N 1.0 13-AUG-20 MSigDB A 13229
FAX000578 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGCNHNCWYCCYCATTAKTNNDCNMNHYCN which matches annotation for HOXA5: homeobox A5 42 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGCNHNCWYCCYCATTAKTNNDCNMNHYCN which matches annotation for HOXA5: homeobox A5 http://www.broadinstitute.org/gsea/msigdb/cards/V$HOX13_01 M9036 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.87995998666222 N 1.0 13-AUG-20 MSigDB A 13229
FAX000582 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AGAANRTTCN which matches annotation for HSF1: heat shock transcription factor 1 254 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AGAANRTTCN which matches annotation for HSF1: heat shock transcription factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$HSF1_01 M19734 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.6742340210003 N 1.0 13-AUG-20 MSigDB A 13229
FAX000585 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NNWWWWNGMCACGTCATYNYWNNN. Motif does not match any known transcription factor 67 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NNWWWWNGMCACGTCATYNYWNNN. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$HTF_01 M14002 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.868504772004242 N 1.0 13-AUG-20 MSigDB A 13229
FAX000589 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif TNYTGGGAATACC. Motif does not match any known transcription factor 208 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif TNYTGGGAATACC. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$IK3_01 M15551 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.410787821508135 N 1.0 13-AUG-20 MSigDB A 13229
FAX000595 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif BNCRSTTTCANTTYY which matches annotation for IRF1: interferon regulatory factor 1 228 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif BNCRSTTTCANTTYY which matches annotation for IRF1: interferon regulatory factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$IRF_Q6 M14066 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 27.3660413408742 N 1.0 13-AUG-20 MSigDB A 13229
FAX000598 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TCAAAG which matches annotation for LEF1: lymphoid enhancer-binding factor 1
TCF1: transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor 201 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TCAAAG which matches annotation for LEF1: lymphoid enhancer-binding factor 1
TCF1: transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor http://www.broadinstitute.org/gsea/msigdb/cards/V$LEF1_Q2 M3572 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.126352577458163 N 1.0 13-AUG-20 MSigDB A 13229
FAX000601 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AATTAATTAA which matches annotation for LHX3: LIM homeobox 3 211 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif AATTAATTAA which matches annotation for LHX3: LIM homeobox 3 http://www.broadinstitute.org/gsea/msigdb/cards/V$LHX3_01 M11495 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.55882552383536 N 1.0 13-AUG-20 MSigDB A 13229
FAX000604 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCGNNAGTRACCC which matches annotation for NR1H3: nuclear receptor subfamily 1, group H, member 3 86 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCGNNAGTRACCC which matches annotation for NR1H3: nuclear receptor subfamily 1, group H, member 3 http://www.broadinstitute.org/gsea/msigdb/cards/V$LXR_DR4_Q3 M5331 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 8.65690785097102 N 1.0 13-AUG-20 MSigDB A 13229
FAX000611 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CTCTAAAAATAACYCY. Motif does not match any known transcription factor 132 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CTCTAAAAATAACYCY. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$MEF2_01 M2501 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 15.0669315965102 N 1.0 13-AUG-20 MSigDB A 13229
FAX000614 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NNTGTTACTAAAAATAGAAMNN. Motif does not match any known transcription factor 23 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NNTGTTACTAAAAATAGAAMNN. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$MEF2_04 M19969 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.0 N 1.0 13-AUG-20 MSigDB A 13229
FAX000617 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACAGTTTTAYGR which matches annotation for MEIS1: Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)
HOXA9: homeobox A9 136 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACAGTTTTAYGR which matches annotation for MEIS1: Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)
HOXA9: homeobox A9 http://www.broadinstitute.org/gsea/msigdb/cards/V$MEIS1BHOXA9_01 M8376 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 2.48828021088337 N 1.0 13-AUG-20 MSigDB A 13229
FAX000620 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CKSNYTAAAAAWRMCY. Motif does not match any known transcription factor 252 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif CKSNYTAAAAAWRMCY. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$MMEF2_Q6 M19101 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.348951578749 N 1.0 13-AUG-20 MSigDB A 13229
FAX000623 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNGNCAGTTN which matches annotation for MYB: v-myb myeloblastosis viral oncogene homolog (avian) 231 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNGNCAGTTN which matches annotation for MYB: v-myb myeloblastosis viral oncogene homolog (avian) http://www.broadinstitute.org/gsea/msigdb/cards/V$MYB_Q3 M14466 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.46622310985499 N 1.0 13-AUG-20 MSigDB A 13229
FAX000628 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNNNCACGTGNNNNNNN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)
MAX: MYC associated factor X 231 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNNNNCACGTGNNNNNNN which matches annotation for MYC: v-myc myelocytomatosis viral oncogene homolog (avian)
MAX: MYC associated factor X http://www.broadinstitute.org/gsea/msigdb/cards/V$MYCMAX_03 M17944 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 20.0577157464192 N 1.0 13-AUG-20 MSigDB A 13229
FAX000631 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SRACAGGTGKYG which matches annotation for MYOD1: myogenic differentiation 1 241 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SRACAGGTGKYG which matches annotation for MYOD1: myogenic differentiation 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$MYOD_01 M12599 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.0 N 1.0 13-AUG-20 MSigDB A 13229
FAX000634 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RGCAGSTG which matches annotation for MYOG: myogenin (myogenic factor 4) 236 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif RGCAGSTG which matches annotation for MYOG: myogenin (myogenic factor 4) http://www.broadinstitute.org/gsea/msigdb/cards/V$MYOGENIN_Q6 M10411 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.13946287143453 N 1.0 13-AUG-20 MSigDB A 13229
FAX000637 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif KNNNKAGGGGNAA. Motif does not match any known transcription factor 219 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif KNNNKAGGGGNAA. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$MZF1_02 M18254 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.32476563477672 N 1.0 13-AUG-20 MSigDB A 13229
FAX000640 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNTTGGCNNNNNNCCNNN which matches annotation for NF1: neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) 242 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNTTGGCNNNNNNCCNNN which matches annotation for NF1: neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) http://www.broadinstitute.org/gsea/msigdb/cards/V$NF1_Q6 M4803 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.306591424748386 N 1.0 13-AUG-20 MSigDB A 13229
FAX000646 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGGAMTTYCC which matches annotation for NFKB
RELA: v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) 242 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGGAMTTYCC which matches annotation for NFKB
RELA: v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) http://www.broadinstitute.org/gsea/msigdb/cards/V$NFKAPPAB_01 M9949 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 46.3249754161476 N 1.0 13-AUG-20 MSigDB A 13229
FAX000651 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NNNRRCCAATSRGNNN. Motif does not match any known transcription factor 231 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NNNRRCCAATSRGNNN. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$NFY_01 M4225 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 16.1178234367142 N 1.0 13-AUG-20 MSigDB A 13229
FAX000655 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif WTGCGTGGGYGG which matches annotation for EGR4: early growth response 4 237 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif WTGCGTGGGYGG which matches annotation for EGR4: early growth response 4 http://www.broadinstitute.org/gsea/msigdb/cards/V$NGFIC_01 M8101 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 25.6352928527699 N 1.0 13-AUG-20 MSigDB A 13229
FAX000658 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CWTAATTG which matches annotation for NKX2-5: NK2 transcription factor related, locus 5 (Drosophila) 244 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif CWTAATTG which matches annotation for NKX2-5: NK2 transcription factor related, locus 5 (Drosophila) http://www.broadinstitute.org/gsea/msigdb/cards/V$NKX25_02 M10704 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.3335265140539 N 1.0 13-AUG-20 MSigDB A 13229
FAX000665 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTGCTGAGTCAKN which matches annotation for NFE2L2: nuclear factor (erythroid-derived 2)-like 2 239 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NTGCTGAGTCAKN which matches annotation for NFE2L2: nuclear factor (erythroid-derived 2)-like 2 http://www.broadinstitute.org/gsea/msigdb/cards/V$NRF2_Q4 M14141 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 20.6478239513074 N 1.0 13-AUG-20 MSigDB A 13229
FAX000710 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCTTTGNCCY which matches annotation for PPARA: peroxisome proliferative activated receptor, alpha 241 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGACCTTTGNCCY which matches annotation for PPARA: peroxisome proliferative activated receptor, alpha http://www.broadinstitute.org/gsea/msigdb/cards/V$PPAR_DR1_Q2 M13889 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 5.28928023558812 N 1.0 13-AUG-20 MSigDB A 13229
FAX000713 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NWNAGRACAN which matches annotation for NR3C1: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 243 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NWNAGRACAN which matches annotation for NR3C1: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) http://www.broadinstitute.org/gsea/msigdb/cards/V$PR_Q2 M19331 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 0.0 N 1.0 13-AUG-20 MSigDB A 13229
FAX000719 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GCACCCAWGGGTGM which matches annotation for ZNF423: zinc finger protein 423 9 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GCACCCAWGGGTGM which matches annotation for ZNF423: zinc finger protein 423 http://www.broadinstitute.org/gsea/msigdb/cards/V$ROAZ_01 M5297 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 6.28410914927769 N 1.0 13-AUG-20 MSigDB A 13229
FAX000722 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNAACATCTGGA which matches annotation for ZNF238: zinc finger protein 238 192 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNAACATCTGGA which matches annotation for ZNF238: zinc finger protein 238 http://www.broadinstitute.org/gsea/msigdb/cards/V$RP58_01 M2120 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.46422018348624 N 1.0 13-AUG-20 MSigDB A 13229
FAX000725 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif ANKCTAWAAATAGMHNN which matches annotation for MEF2A: MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) 199 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif ANKCTAWAAATAGMHNN which matches annotation for MEF2A: MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) http://www.broadinstitute.org/gsea/msigdb/cards/V$RSRFC4_Q2 M9937 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 9.11650485977923 N 1.0 13-AUG-20 MSigDB A 13229
FAX000728 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGRCCTTG which matches annotation for SF1: splicing factor 1 234 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TGRCCTTG which matches annotation for SF1: splicing factor 1 http://www.broadinstitute.org/gsea/msigdb/cards/V$SF1_Q6 M8812 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 13.9724866793875 N 1.0 13-AUG-20 MSigDB A 13229
TAX023871 GO:0042493 biological_process response to drug 731 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042493 PAGER curation team PAGER-contact@googlegroups.com 540.523447696539 2 13-AUG-20 GOA A 21894
WAG000383 Chondroitin sulfate biosynthesis 21 Homo sapiens Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide units and form proteglycans by covalently attaching to their core proteins. Chondroitin sulfate (CS) is a glycosaminoglycan with the disaccharide unit of beta-D-galactosamine (Galc) and beta-D-glucuronic acid (GlcA), and often modified with ester-linked sulfate at certain positions. Dermatan sulfate (DS) is a modified form of CS, in which a portion of D-glucurote residues is epimerized to L-idurotes (IdoA). CS and DS are linked to serine residues in core proteins via a linkage tetrasaccharide formed by the transfer of xylose and three more residues [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00532 PAGER curation team PAGER-contact@googlegroups.com 951.620243653437 1.0 13-AUG-20 KEGG P 199
WAG000384 Small cell lung cancer 78 Homo sapiens Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of termil differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05222 PAGER curation team PAGER-contact@googlegroups.com 2282.34241222612 1.0 13-AUG-20 KEGG P 199
WAG000385 Styrene degradation 18 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00643 PAGER curation team PAGER-contact@googlegroups.com 532.810806338174 1.0 13-AUG-20 KEGG P 199
WAG000386 Aminosugars metabolism 33 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00530 PAGER curation team PAGER-contact@googlegroups.com 910.743555515841 1.0 13-AUG-20 KEGG P 199
WAG000387 Thiamine metabolism 43 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00730 PAGER curation team PAGER-contact@googlegroups.com 1695.95253844938 1.0 13-AUG-20 KEGG P 199
WAG000388 Long-term potentiation 56 Homo sapiens Hippocampal long-term potentiation (LTP), a long-lasting increase in syptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kise II (CaM KII) . Constitutively active CaM kise II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsyptic Ca2+ increases generated through NMDA receptors activate several sigl transduction pathways including the Erk/MAP kise and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptiol pathway may increase expression of a family of genes required for late-phase LTP (L-LTP). http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04720 PAGER curation team PAGER-contact@googlegroups.com 2633.41531295885 1.0 13-AUG-20 KEGG P 199
WAG000389 Vibrio cholerae infection 51 Homo sapiens Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the ER, the A-chain (CTXA) is recognized by protein disulfide isomerase (PDI), unfolded, and delivered to the membrane where the membrane-associated ER-oxidase, Ero1, oxidizes PDI to release the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol and induces water and electrolyte secretion by increasing cAMP levels via adenylate cyclase (AC) to exert toxicity. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05110 PAGER curation team PAGER-contact@googlegroups.com 1311.30616080423 1.0 13-AUG-20 KEGG P 199
WAG000390 Alanine and aspartate metabolism 40 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00252 PAGER curation team PAGER-contact@googlegroups.com 1581.84221416082 1.0 13-AUG-20 KEGG P 199
WAG000391 Adherens junction 60 Homo sapiens Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kises (RTKs) and cytoplasmic tyrosine kises (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kise II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of sigling beta-catenin. Wnt sigling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of sigling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce sigls through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04520 PAGER curation team PAGER-contact@googlegroups.com 1824.61772660722 1.0 13-AUG-20 KEGG P 199
WAG000392 Glycosaminoglycan degradation 16 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00531 PAGER curation team PAGER-contact@googlegroups.com 648.734629327265 1.0 13-AUG-20 KEGG P 199
TAX023719 GO:0042214 biological_process terpene metabolic process 3 Homo sapiens The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042214 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023720 GO:0042218 biological_process 1-aminocyclopropane-1-carboxylate biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042218 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023721 GO:0042219 biological_process cellular modified amino acid catabolic process 28 Homo sapiens The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042219 PAGER curation team PAGER-contact@googlegroups.com 60.1208921445065 2 13-AUG-20 GOA A 21894
TAX023722 GO:0042220 biological_process response to cocaine 32 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042220 PAGER curation team PAGER-contact@googlegroups.com 120.615865726778 2 13-AUG-20 GOA A 21894
TAX023723 GO:0042221 biological_process response to chemical 2510 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042221 PAGER curation team PAGER-contact@googlegroups.com 568.305090807974 2 13-AUG-20 GOA A 21894
WAG000993 Citrate cycle (TCA cycle) 48 Homo sapiens The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the fil steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies DH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00020 PAGER curation team PAGER-contact@googlegroups.com 4148.78396895834 1.0 13-AUG-20 KEGG P 199
WAG000994 Fructose and mannose metabolism 42 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00051 PAGER curation team PAGER-contact@googlegroups.com 1271.38437465318 1.0 13-AUG-20 KEGG P 199
WAG000995 Starch and sucrose metabolism 73 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00500 PAGER curation team PAGER-contact@googlegroups.com 347.262725864661 1.0 13-AUG-20 KEGG P 199
WAG000996 Glycan structures - degradation 27 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa01032 PAGER curation team PAGER-contact@googlegroups.com 363.451238418539 1.0 13-AUG-20 KEGG P 199
WAG000997 Limonene and pinene degradation 15 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00903 PAGER curation team PAGER-contact@googlegroups.com 827.807429317113 1.0 13-AUG-20 KEGG P 199
WAG000998 Arginine and proline metabolism 30 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00330 PAGER curation team PAGER-contact@googlegroups.com 833.221095094665 1.0 13-AUG-20 KEGG P 199
WAG000999 Protein export 8 Homo sapiens The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functiolly different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03060 PAGER curation team PAGER-contact@googlegroups.com 3000.73646789951 1.0 13-AUG-20 KEGG P 199
WAG001000 Dentatorubropallidoluysian atrophy (DRPLA) 14 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05050 PAGER curation team PAGER-contact@googlegroups.com 188.502888381747 1.0 13-AUG-20 KEGG P 199
WAG001001 Nucleotide excision repair 41 Homo sapiens Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky D damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged D involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by R polymerase II (RP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03420 PAGER curation team PAGER-contact@googlegroups.com 12956.8418433764 1.0 13-AUG-20 KEGG P 199
WAG001003 Phenylalanine, tyrosine and tryptophan biosynthesis 27 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00400 PAGER curation team PAGER-contact@googlegroups.com 1492.71713119266 1.0 13-AUG-20 KEGG P 199
WAG001004 Ascorbate and aldarate metabolism 14 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00053 PAGER curation team PAGER-contact@googlegroups.com 535.711763508237 1.0 13-AUG-20 KEGG P 199
WAG001005 Proteasome 41 Homo sapiens The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, sigl transduction pathways, antigen processing for appropriate immune responses, stress sigling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that eble the proteasome to degrade ubiquitited proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03050 PAGER curation team PAGER-contact@googlegroups.com 25828.5825712488 1.0 13-AUG-20 KEGG P 199
TAX023724 GO:0042222 biological_process interleukin-1 biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042222 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023725 GO:0042226 biological_process interleukin-6 biosynthetic process 2 Homo sapiens The chemical reactions and pathways resulting in the formation of interleukin-6. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042226 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023727 GO:0042231 biological_process interleukin-13 biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of interleukin-13. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042231 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023728 GO:0042245 biological_process RNA repair 2 Homo sapiens Any process that results in the repair of damaged RNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042245 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023729 GO:0042246 biological_process tissue regeneration 42 Homo sapiens The regrowth of lost or destroyed tissues. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042246 PAGER curation team PAGER-contact@googlegroups.com 13.0708721105368 2 13-AUG-20 GOA A 21894
TAX023730 GO:0042247 biological_process establishment of planar polarity of follicular epithelium 1 Homo sapiens Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042247 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023731 GO:0042249 biological_process establishment of planar polarity of embryonic epithelium 4 Homo sapiens Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042249 PAGER curation team PAGER-contact@googlegroups.com 79.8458149779736 2 13-AUG-20 GOA A 21894
TAX023732 GO:0042253 biological_process granulocyte macrophage colony-stimulating factor biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042253 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023733 GO:0042254 biological_process ribosome biogenesis 28 Homo sapiens A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042254 PAGER curation team PAGER-contact@googlegroups.com 322.257706848898 2 13-AUG-20 GOA A 21894
TAX023734 GO:0042255 biological_process ribosome assembly 13 Homo sapiens The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042255 PAGER curation team PAGER-contact@googlegroups.com 32.0800450958286 2 13-AUG-20 GOA A 21894
TAX023736 GO:0042262 biological_process DNA protection 5 Homo sapiens Any process in which DNA is protected from damage by, for example, oxidative stress. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042262 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023737 GO:0042264 biological_process peptidyl-aspartic acid hydroxylation 4 Homo sapiens The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042264 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023738 GO:0042265 biological_process peptidyl-asparagine hydroxylation 1 Homo sapiens The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042265 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023739 GO:0042267 biological_process natural killer cell mediated cytotoxicity 20 Homo sapiens The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042267 PAGER curation team PAGER-contact@googlegroups.com 94.3829131516207 2 13-AUG-20 GOA A 21894
TAX023740 GO:0042268 biological_process regulation of cytolysis 16 Homo sapiens Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042268 PAGER curation team PAGER-contact@googlegroups.com 19.7982619031505 2 13-AUG-20 GOA A 21894
TAX023741 GO:0042269 biological_process regulation of natural killer cell mediated cytotoxicity 34 Homo sapiens Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042269 PAGER curation team PAGER-contact@googlegroups.com 33.3919325535256 2 13-AUG-20 GOA A 21894
TAX023742 GO:0042270 biological_process protection from natural killer cell mediated cytotoxicity 3 Homo sapiens The process of protecting a cell from natural killer cell mediated cytotoxicity. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042270 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000393 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 26 Homo sapiens Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis gene result in a genetic disorder, paroxysmal nocturl hemoglobinuria. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00563 PAGER curation team PAGER-contact@googlegroups.com 1640.07258543497 1.0 13-AUG-20 KEGG P 199
WAG000394 Tetrachloroethene degradation 19 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00625 PAGER curation team PAGER-contact@googlegroups.com 975.147506877426 1.0 13-AUG-20 KEGG P 199
WAG000395 Pyrimidine metabolism 98 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00240 PAGER curation team PAGER-contact@googlegroups.com 3229.9467655314 1.0 13-AUG-20 KEGG P 199
TAX023872 GO:0042494 biological_process detection of bacterial lipoprotein 4 Homo sapiens The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042494 PAGER curation team PAGER-contact@googlegroups.com 226.45236784141 2 13-AUG-20 GOA A 21894
TAX023873 GO:0042495 biological_process detection of triacyl bacterial lipopeptide 2 Homo sapiens The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042495 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023874 GO:0042496 biological_process detection of diacyl bacterial lipopeptide 2 Homo sapiens The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042496 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023875 GO:0042497 molecular_function triacyl lipopeptide binding 1 Homo sapiens Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042497 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023876 GO:0042500 molecular_function aspartic endopeptidase activity, intramembrane cleaving 6 Homo sapiens Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042500 PAGER curation team PAGER-contact@googlegroups.com 38.857938718663 2 13-AUG-20 GOA A 21894
TAX023877 GO:0042501 biological_process serine phosphorylation of STAT protein 4 Homo sapiens The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042501 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX023878 GO:0042509 biological_process regulation of tyrosine phosphorylation of STAT protein 72 Homo sapiens Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042509 PAGER curation team PAGER-contact@googlegroups.com 1152.78552492047 2 13-AUG-20 GOA A 21894
WAG000985 Leukocyte transendothelial migration 103 Homo sapiens """Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kise p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell sigls that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated sigls activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the """"""""endothelial passage"""""""" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces DPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteises and loss of VE-cadherin-mediated adhesion.""" http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04670 PAGER curation team PAGER-contact@googlegroups.com 2467.78859485184 1.0 13-AUG-20 KEGG P 199
WAG000986 Neuroactive ligand-receptor interaction 240 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04080 PAGER curation team PAGER-contact@googlegroups.com 5329.73366593939 1.0 13-AUG-20 KEGG P 199
WAG000987 Cyanoamino acid metabolism 29 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00460 PAGER curation team PAGER-contact@googlegroups.com 1519.26475596263 1.0 13-AUG-20 KEGG P 199
WAG000988 Ubiquitin mediated proteolysis 121 Homo sapiens Protein ubiquitition plays an important role in eukaryotic cellular processes. It mainly functions as a sigl for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, med E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitition. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04120 PAGER curation team PAGER-contact@googlegroups.com 2031.90100477016 1.0 13-AUG-20 KEGG P 199
WAG000989 Bladder cancer 35 Homo sapiens The urothelium covers the lumil surface of almost the entire uriry tract, extending from the rel pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the rel pelvis and ureter account for only approximately 7% of the total. Urothelial tumours arise and evolve through divergent phenotypic pathways. Some tumours progress from urothelial hyperplasia to low-grade non-invasive superficial papillary tumours. More aggressive variants arise either from flat, high-grade carcinoma in situ (CIS) and progress to invasive tumours, or they arise de novo as invasive tumours. Low-grade papillary tumors frequently show a constitutive activation of the receptor tyrosine kise-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. In contrast, CIS and invasive tumors frequently show alterations in the TP53 and RB genes and pathways. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteises (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF). http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05219 PAGER curation team PAGER-contact@googlegroups.com 2832.9586645469 1.0 13-AUG-20 KEGG P 199
WAG000990 Glycerophospholipid metabolism 74 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00564 PAGER curation team PAGER-contact@googlegroups.com 1382.22925103797 1.0 13-AUG-20 KEGG P 199
WAG000991 Antigen processing and presentation 61 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04612 PAGER curation team PAGER-contact@googlegroups.com 901.035855489284 1.0 13-AUG-20 KEGG P 199
WAG000992 Renin-angiotensin system 17 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04614 PAGER curation team PAGER-contact@googlegroups.com 696.307501192959 1.0 13-AUG-20 KEGG P 199
TAX023879 GO:0042531 biological_process positive regulation of tyrosine phosphorylation of STAT protein 62 Homo sapiens Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042531 PAGER curation team PAGER-contact@googlegroups.com 1350.03913051775 2 13-AUG-20 GOA A 21894
WAG000030 IL12 signaling mediated by STAT4 25 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 3004.9044055866 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000031 Endothelins 32 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=endothelinpathway&pathway_me=Endothelins&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1862.83175998625 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000032 TCR signaling in naive CD4+ T cells 59 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 4482.47714694628 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000033 IL2-mediated signaling events 38 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=il2_1pathway&pathway_me=IL2-mediated sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 6136.41367364926 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000034 Glypican 1 network 16 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=glypicanpathway&pathway_me=Glypican pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 547.826287075733 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000037 Signaling events mediated by the Hedgehog family 21 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 1064.38278606286 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000038 TRAIL signaling pathway 20 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 4591.54390989638 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000039 Visual signal transduction: Cones 17 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 586.307761067637 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000040 Class IB PI3K non-lipid kinase events 3 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=pi3kcipathway&pathway_me=Class I PI3K sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000041 LPA4-mediated signaling events 5 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=lpa4_pathway&pathway_me=LPA4-mediated%20sigling%20events&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 188.558607956135 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000044 Class I PI3K signaling events mediated by Akt 30 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=pi3kcipathway&pathway_me=Class I PI3K sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1906.79429511693 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000045 Signaling events mediated by HDAC Class III 21 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 855.228881616749 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000047 VEGFR3 signaling in lymphatic endothelium 19 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 3818.24632496218 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000048 Glypican 2 network 2 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=glypicanpathway&pathway_me=Glypican pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX023880 GO:0042532 biological_process negative regulation of tyrosine phosphorylation of STAT protein 11 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042532 PAGER curation team PAGER-contact@googlegroups.com 53.6067705879027 2 13-AUG-20 GOA A 21894
TAX023881 GO:0042534 biological_process regulation of tumor necrosis factor biosynthetic process 20 Homo sapiens Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042534 PAGER curation team PAGER-contact@googlegroups.com 58.5213395763605 2 13-AUG-20 GOA A 21894
TAX023882 GO:0042535 biological_process positive regulation of tumor necrosis factor biosynthetic process 11 Homo sapiens Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042535 PAGER curation team PAGER-contact@googlegroups.com 50.7910014513788 2 13-AUG-20 GOA A 21894
TAX023883 GO:0042536 biological_process negative regulation of tumor necrosis factor biosynthetic process 6 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042536 PAGER curation team PAGER-contact@googlegroups.com 38.857938718663 2 13-AUG-20 GOA A 21894
TAX023884 GO:0042537 biological_process benzene-containing compound metabolic process 23 Homo sapiens The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042537 PAGER curation team PAGER-contact@googlegroups.com 258.681893095244 2 13-AUG-20 GOA A 21894
TAX023701 GO:0042162 molecular_function telomeric DNA binding 36 Homo sapiens Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042162 PAGER curation team PAGER-contact@googlegroups.com 1218.98068343063 2 13-AUG-20 GOA A 21894
TAX023702 GO:0042163 molecular_function interleukin-12 beta subunit binding 1 Homo sapiens Interacting selectively and non-covalently with the beta subunit of interleukin-12. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042163 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023703 GO:0042164 molecular_function interleukin-12 alpha subunit binding 1 Homo sapiens Interacting selectively and non-covalently with the alpha subunit of interleukin-12. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042164 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023704 GO:0042165 molecular_function neurotransmitter binding 51 Homo sapiens Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042165 PAGER curation team PAGER-contact@googlegroups.com 790.439591076242 2 13-AUG-20 GOA A 21894
TAX023705 GO:0042166 molecular_function acetylcholine binding 17 Homo sapiens Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042166 PAGER curation team PAGER-contact@googlegroups.com 4018.67921607459 2 13-AUG-20 GOA A 21894
TAX023706 GO:0042167 biological_process heme catabolic process 7 Homo sapiens The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042167 PAGER curation team PAGER-contact@googlegroups.com 451.909622440525 2 13-AUG-20 GOA A 21894
TAX023707 GO:0042168 biological_process heme metabolic process 29 Homo sapiens The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042168 PAGER curation team PAGER-contact@googlegroups.com 309.929769203825 2 13-AUG-20 GOA A 21894
WAG000374 Allograft rejection 22 Homo sapiens Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of antigen presentation. In the direct pathway, recipient T cells react to intact allogeneic MHC molecules expressed on the surface of donor cells. This pathway would activate host CD4 or CD8 T cells. In contrast, donor MHC molecules (and all other proteins) shed from the graft can be taken up by host APCs and presented to recipient T cells in the context of self-MHC molecules - the indirect pathway. Such presentation activates predomintly CD4 T cells. A direct cytotoxic T-cell attack on graft cells can be made only by T cells that recognize the graft MHC molecules directly. Nontheless, T cells with indirect allospecificity can contribute to graft rejection by activating macrophages, which cause tissue injury and fibrosis, and are also likely to be important in the development of an alloantibody response to graft. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05330 PAGER curation team PAGER-contact@googlegroups.com 4311.67511188168 1.0 13-AUG-20 KEGG P 199
WAG000375 Focal adhesion 174 Homo sapiens Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctiol plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are siglling molecules, including different protein kises and phosphatases, their substrates, and various adapter proteins. Integrin sigling is dependent upon the non-receptor tyrosine kise activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream sigling events. These siglling events culmite in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated siglling. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04510 PAGER curation team PAGER-contact@googlegroups.com 5480.3855131441 1.0 13-AUG-20 KEGG P 199
WAG000376 Purine metabolism 144 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00230 PAGER curation team PAGER-contact@googlegroups.com 8194.62396633701 1.0 13-AUG-20 KEGG P 199
WAG000377 Ether lipid metabolism 26 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00565 PAGER curation team PAGER-contact@googlegroups.com 3553.90744290741 1.0 13-AUG-20 KEGG P 199
WAG000378 Tyrosine metabolism 57 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00350 PAGER curation team PAGER-contact@googlegroups.com 772.860835214789 1.0 13-AUG-20 KEGG P 199
WAG000379 Non-small cell lung cancer 45 Homo sapiens Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS, c-erbB-2 and EML4-ALK, and ictivation of tumorsuppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene ictivate GTPase activity and the p21-RAS protein continuously transmits growth sigls to the nucleus. Overexpression of c-erbB-2 or EGFR leads to a proliferative advantage. EML4-ALK fusion leads to constitutive ALK activation, which causes cell proliferation, invasion, and inhibition of apoptosis. Ictivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. Loss of p16INK4a expression is a common feature of NSCLC. RAR-beta is a nuclear receptor that bears vitamin-A-dependent transcriptiol activity. RASSF1A is able to form heterodimers with Nore-1, an RAS effector.Therefore loss of RASSF1A might shift the balance of RAS activity towards a growth-promoting effect. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05223 PAGER curation team PAGER-contact@googlegroups.com 3567.88108526207 1.0 13-AUG-20 KEGG P 199
WAG000380 Drug metabolism - other enzymes 49 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00983 PAGER curation team PAGER-contact@googlegroups.com 1041.78822459405 1.0 13-AUG-20 KEGG P 199
WAG000381 PPAR signaling pathway 59 Homo sapiens Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03320 PAGER curation team PAGER-contact@googlegroups.com 1265.0951511664 1.0 13-AUG-20 KEGG P 199
WAG000382 Aminoacyl-tRNA biosynthesis 89 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00970 PAGER curation team PAGER-contact@googlegroups.com 1133.92295252747 1.0 13-AUG-20 KEGG P 199
TAX023708 GO:0042169 molecular_function SH2 domain binding 33 Homo sapiens Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042169 PAGER curation team PAGER-contact@googlegroups.com 327.006714477941 2 13-AUG-20 GOA A 21894
TAX023709 GO:0042171 molecular_function lysophosphatidic acid acyltransferase activity 20 Homo sapiens Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042171 PAGER curation team PAGER-contact@googlegroups.com 356.507201068268 2 13-AUG-20 GOA A 21894
TAX023710 GO:0042175 cellular_component nuclear outer membrane-endoplasmic reticulum membrane network 2 Homo sapiens The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042175 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023711 GO:0042176 biological_process regulation of protein catabolic process 362 Homo sapiens Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042176 PAGER curation team PAGER-contact@googlegroups.com 378.681565937862 2 13-AUG-20 GOA A 21894
TAX023712 GO:0042177 biological_process negative regulation of protein catabolic process 120 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042177 PAGER curation team PAGER-contact@googlegroups.com 72.2929289040158 2 13-AUG-20 GOA A 21894
TAX023713 GO:0042178 biological_process xenobiotic catabolic process 10 Homo sapiens The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042178 PAGER curation team PAGER-contact@googlegroups.com 820.264679532644 2 13-AUG-20 GOA A 21894
TAX023714 GO:0042180 biological_process cellular ketone metabolic process 68 Homo sapiens The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042180 PAGER curation team PAGER-contact@googlegroups.com 165.297356484839 2 13-AUG-20 GOA A 21894
TAX023715 GO:0042181 biological_process ketone biosynthetic process 28 Homo sapiens The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042181 PAGER curation team PAGER-contact@googlegroups.com 422.309428604595 2 13-AUG-20 GOA A 21894
TAX023716 GO:0042182 biological_process ketone catabolic process 8 Homo sapiens The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042182 PAGER curation team PAGER-contact@googlegroups.com 9.91853360488798 2 13-AUG-20 GOA A 21894
TAX023717 GO:0042196 biological_process chlorinated hydrocarbon metabolic process 1 Homo sapiens The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042196 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023718 GO:0042197 biological_process halogenated hydrocarbon metabolic process 2 Homo sapiens The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042197 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023805 GO:0042377 biological_process vitamin K catabolic process 2 Homo sapiens The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042377 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023806 GO:0042379 molecular_function chemokine receptor binding 60 Homo sapiens Interacting selectively and non-covalently with any chemokine receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042379 PAGER curation team PAGER-contact@googlegroups.com 4555.56937766948 2 13-AUG-20 GOA A 21894
TAX023808 GO:0042383 cellular_component sarcolemma 91 Homo sapiens The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042383 PAGER curation team PAGER-contact@googlegroups.com 315.621642978475 2 13-AUG-20 GOA A 21894
TAX023809 GO:0042391 biological_process regulation of membrane potential 400 Homo sapiens Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042391 PAGER curation team PAGER-contact@googlegroups.com 266.58730102192 2 13-AUG-20 GOA A 21894
TAX023810 GO:0042392 molecular_function sphingosine-1-phosphate phosphatase activity 5 Homo sapiens Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042392 PAGER curation team PAGER-contact@googlegroups.com 23.9931740614334 2 13-AUG-20 GOA A 21894
TAX023811 GO:0042393 molecular_function histone binding 175 Homo sapiens Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042393 PAGER curation team PAGER-contact@googlegroups.com 145.246136046401 2 13-AUG-20 GOA A 21894
TAX023812 GO:0042396 biological_process phosphagen biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042396 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023813 GO:0042398 biological_process cellular modified amino acid biosynthetic process 44 Homo sapiens The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042398 PAGER curation team PAGER-contact@googlegroups.com 258.397952423691 2 13-AUG-20 GOA A 21894
TAX023814 GO:0042401 biological_process cellular biogenic amine biosynthetic process 21 Homo sapiens The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042401 PAGER curation team PAGER-contact@googlegroups.com 309.698394422777 2 13-AUG-20 GOA A 21894
TAX023815 GO:0042402 biological_process cellular biogenic amine catabolic process 23 Homo sapiens The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042402 PAGER curation team PAGER-contact@googlegroups.com 239.68670245414 2 13-AUG-20 GOA A 21894
TAX023816 GO:0042403 biological_process thyroid hormone metabolic process 15 Homo sapiens The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042403 PAGER curation team PAGER-contact@googlegroups.com 182.243665491305 2 13-AUG-20 GOA A 21894
TAX023817 GO:0042404 biological_process thyroid hormone catabolic process 1 Homo sapiens The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042404 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023818 GO:0042405 cellular_component nuclear inclusion body 13 Homo sapiens An intranuclear focus at which aggregated proteins have been sequestered. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042405 PAGER curation team PAGER-contact@googlegroups.com 257.164762011664 2 13-AUG-20 GOA A 21894
TAX023819 GO:0042406 cellular_component extrinsic component of endoplasmic reticulum membrane 5 Homo sapiens The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042406 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023820 GO:0042407 biological_process cristae formation 21 Homo sapiens The assembly of cristae, the inwards folds of the inner mitochondrial membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042407 PAGER curation team PAGER-contact@googlegroups.com 237.772714055119 2 13-AUG-20 GOA A 21894
TAX023821 GO:0042412 biological_process taurine biosynthetic process 2 Homo sapiens The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042412 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023822 GO:0042413 biological_process carnitine catabolic process 1 Homo sapiens The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042413 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023823 GO:0042414 biological_process epinephrine metabolic process 3 Homo sapiens The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042414 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX023824 GO:0042415 biological_process norepinephrine metabolic process 12 Homo sapiens The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042415 PAGER curation team PAGER-contact@googlegroups.com 4.19867549668874 2 13-AUG-20 GOA A 21894
TAX023825 GO:0042416 biological_process dopamine biosynthetic process 10 Homo sapiens The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042416 PAGER curation team PAGER-contact@googlegroups.com 127.984153943783 2 13-AUG-20 GOA A 21894
TAX023826 GO:0042417 biological_process dopamine metabolic process 28 Homo sapiens The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042417 PAGER curation team PAGER-contact@googlegroups.com 423.391645324926 2 13-AUG-20 GOA A 21894
WAG000396 Alkaloid biosynthesis I 15 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00950 PAGER curation team PAGER-contact@googlegroups.com 2106.55910015735 1.0 13-AUG-20 KEGG P 199
TAX023827 GO:0042418 biological_process epinephrine biosynthetic process 2 Homo sapiens The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042418 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023828 GO:0042420 biological_process dopamine catabolic process 8 Homo sapiens The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042420 PAGER curation team PAGER-contact@googlegroups.com 365.232289768464 2 13-AUG-20 GOA A 21894
TAX023829 GO:0042421 biological_process norepinephrine biosynthetic process 6 Homo sapiens The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042421 PAGER curation team PAGER-contact@googlegroups.com 17.1866295264624 2 13-AUG-20 GOA A 21894
TAX023830 GO:0042423 biological_process catecholamine biosynthetic process 18 Homo sapiens The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042423 PAGER curation team PAGER-contact@googlegroups.com 154.192169756534 2 13-AUG-20 GOA A 21894
TAX023831 GO:0042424 biological_process catecholamine catabolic process 9 Homo sapiens The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042424 PAGER curation team PAGER-contact@googlegroups.com 292.835319527254 2 13-AUG-20 GOA A 21894
TAX023832 GO:0042426 biological_process choline catabolic process 6 Homo sapiens The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042426 PAGER curation team PAGER-contact@googlegroups.com 244.685539236375 2 13-AUG-20 GOA A 21894
TAX023833 GO:0042427 biological_process serotonin biosynthetic process 3 Homo sapiens The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042427 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX023834 GO:0042428 biological_process serotonin metabolic process 10 Homo sapiens The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042428 PAGER curation team PAGER-contact@googlegroups.com 82.7131845160327 2 13-AUG-20 GOA A 21894
TAX023835 GO:0042430 biological_process indole-containing compound metabolic process 24 Homo sapiens The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042430 PAGER curation team PAGER-contact@googlegroups.com 313.321976226388 2 13-AUG-20 GOA A 21894
TAX023836 GO:0042431 biological_process indole metabolic process 1 Homo sapiens The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042431 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023838 GO:0042436 biological_process indole-containing compound catabolic process 10 Homo sapiens The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042436 PAGER curation team PAGER-contact@googlegroups.com 845.357702788458 2 13-AUG-20 GOA A 21894
TAX023839 GO:0042438 biological_process melanin biosynthetic process 12 Homo sapiens The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042438 PAGER curation team PAGER-contact@googlegroups.com 293.900782974614 2 13-AUG-20 GOA A 21894
TAX023840 GO:0042439 biological_process ethanolamine-containing compound metabolic process 7 Homo sapiens The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042439 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023841 GO:0042440 biological_process pigment metabolic process 64 Homo sapiens The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042440 PAGER curation team PAGER-contact@googlegroups.com 202.485989596192 2 13-AUG-20 GOA A 21894
TAX023842 GO:0042441 biological_process eye pigment metabolic process 4 Homo sapiens The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042441 PAGER curation team PAGER-contact@googlegroups.com 226.45236784141 2 13-AUG-20 GOA A 21894
TAX023843 GO:0042445 biological_process hormone metabolic process 184 Homo sapiens The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042445 PAGER curation team PAGER-contact@googlegroups.com 322.489812842942 2 13-AUG-20 GOA A 21894
TAX023844 GO:0042446 biological_process hormone biosynthetic process 61 Homo sapiens The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042446 PAGER curation team PAGER-contact@googlegroups.com 375.827223786137 2 13-AUG-20 GOA A 21894
TAX023845 GO:0042447 biological_process hormone catabolic process 14 Homo sapiens The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042447 PAGER curation team PAGER-contact@googlegroups.com 89.1757438228743 2 13-AUG-20 GOA A 21894
TAX023846 GO:0042448 biological_process progesterone metabolic process 13 Homo sapiens The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042448 PAGER curation team PAGER-contact@googlegroups.com 306.623797627584 2 13-AUG-20 GOA A 21894
TAX023847 GO:0042450 biological_process arginine biosynthetic process via ornithine 2 Homo sapiens The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042450 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX023848 GO:0042451 biological_process purine nucleoside biosynthetic process 23 Homo sapiens The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042451 PAGER curation team PAGER-contact@googlegroups.com 925.298212525175 2 13-AUG-20 GOA A 21894
TAX023849 GO:0042454 biological_process ribonucleoside catabolic process 21 Homo sapiens The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042454 PAGER curation team PAGER-contact@googlegroups.com 176.602794570083 2 13-AUG-20 GOA A 21894
TAX023850 GO:0042455 biological_process ribonucleoside biosynthetic process 40 Homo sapiens The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042455 PAGER curation team PAGER-contact@googlegroups.com 789.059495603183 2 13-AUG-20 GOA A 21894
TAX023851 GO:0042461 biological_process photoreceptor cell development 35 Homo sapiens Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042461 PAGER curation team PAGER-contact@googlegroups.com 47.1674733358334 2 13-AUG-20 GOA A 21894
TAX023852 GO:0042462 biological_process eye photoreceptor cell development 33 Homo sapiens Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042462 PAGER curation team PAGER-contact@googlegroups.com 51.0914977009423 2 13-AUG-20 GOA A 21894
TAX023853 GO:0042470 cellular_component melanosome 100 Homo sapiens A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042470 PAGER curation team PAGER-contact@googlegroups.com 208.555503802411 2 13-AUG-20 GOA A 21894
TAX023854 GO:0042471 biological_process ear morphogenesis 4 Homo sapiens The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042471 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023855 GO:0042472 biological_process inner ear morphogenesis 53 Homo sapiens The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042472 PAGER curation team PAGER-contact@googlegroups.com 65.6856797614446 2 13-AUG-20 GOA A 21894
TAX023856 GO:0042473 biological_process outer ear morphogenesis 9 Homo sapiens The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042473 PAGER curation team PAGER-contact@googlegroups.com 78.5975352971164 2 13-AUG-20 GOA A 21894
TAX030125 GO:0072708 biological_process response to sorbitol 5 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072708 PAGER curation team PAGER-contact@googlegroups.com 188.558607956135 2 13-AUG-20 GOA A 21894
TAX030126 GO:0072709 biological_process cellular response to sorbitol 3 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072709 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX030127 GO:0072710 biological_process response to hydroxyurea 8 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072710 PAGER curation team PAGER-contact@googlegroups.com 116.239046253618 2 13-AUG-20 GOA A 21894
WAG001071 Downstream signaling in na??ve CD8+ T cells 43 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=cd8tcrpathway&pathway_me=TCR%20sigling%20in%20%EFve%20CD8+%20T%20cells&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2521.73531491132 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001072 Plasma membrane estrogen receptor signaling 24 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=er_nongenomic_pathway&pathway_me=Plasma membrane estrogen receptor sigling&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3005.87428400848 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001074 Glypican pathway 3 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=glypicanpathway&pathway_me=Glypican pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001075 a4b1 and a4b7 Integrin signaling 3 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX030129 GO:0072714 biological_process response to selenite ion 1 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072714 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030130 GO:0072715 biological_process cellular response to selenite ion 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072715 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030131 GO:0072716 biological_process response to actinomycin D 4 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072716 PAGER curation team PAGER-contact@googlegroups.com 282.003028634361 2 13-AUG-20 GOA A 21894
TAX030132 GO:0072717 biological_process cellular response to actinomycin D 3 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072717 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX030133 GO:0072718 biological_process response to cisplatin 8 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072718 PAGER curation team PAGER-contact@googlegroups.com 9.91853360488798 2 13-AUG-20 GOA A 21894
TAX030134 GO:0072719 biological_process cellular response to cisplatin 5 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072719 PAGER curation team PAGER-contact@googlegroups.com 23.9931740614334 2 13-AUG-20 GOA A 21894
TAX030135 GO:0072720 biological_process response to dithiothreitol 2 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072720 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030136 GO:0072721 biological_process cellular response to dithiothreitol 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072721 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030137 GO:0072733 biological_process response to staurosporine 5 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072733 PAGER curation team PAGER-contact@googlegroups.com 151.800928775248 2 13-AUG-20 GOA A 21894
TAX030138 GO:0072734 biological_process cellular response to staurosporine 5 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072734 PAGER curation team PAGER-contact@googlegroups.com 151.800928775248 2 13-AUG-20 GOA A 21894
TAX030139 GO:0072737 biological_process response to diamide 2 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072737 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030140 GO:0072738 biological_process cellular response to diamide 2 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072738 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030141 GO:0072739 biological_process response to anisomycin 2 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072739 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023743 GO:0042271 biological_process susceptibility to natural killer cell mediated cytotoxicity 4 Homo sapiens The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042271 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023744 GO:0042272 cellular_component nuclear RNA export factor complex 4 Homo sapiens A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042272 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023745 GO:0042273 biological_process ribosomal large subunit biogenesis 26 Homo sapiens A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042273 PAGER curation team PAGER-contact@googlegroups.com 1465.34596477515 2 13-AUG-20 GOA A 21894
TAX023746 GO:0042274 biological_process ribosomal small subunit biogenesis 17 Homo sapiens A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042274 PAGER curation team PAGER-contact@googlegroups.com 1063.21060821278 2 13-AUG-20 GOA A 21894
WIG001772 B-Cell Development 2 Homo sapiens B-Cell Development http://www.proteinlounge.com/pathway/B-Cell Development PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 Protein Lounge P 388
WAG000186 Cytokine-cytokine receptor interaction 243 Homo sapiens Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in inte as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04060 PAGER curation team PAGER-contact@googlegroups.com 2418.16928573511 1.0 13-AUG-20 KEGG P 199
TAX023747 GO:0042275 biological_process error-free postreplication DNA repair 1 Homo sapiens The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042275 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023748 GO:0042276 biological_process error-prone translesion synthesis 20 Homo sapiens The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042276 PAGER curation team PAGER-contact@googlegroups.com 2534.74743248819 2 13-AUG-20 GOA A 21894
TAX023749 GO:0042277 molecular_function peptide binding 290 Homo sapiens Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042277 PAGER curation team PAGER-contact@googlegroups.com 168.01034208692 2 13-AUG-20 GOA A 21894
TAX023750 GO:0042278 biological_process purine nucleoside metabolic process 72 Homo sapiens The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042278 PAGER curation team PAGER-contact@googlegroups.com 356.657272939686 2 13-AUG-20 GOA A 21894
TAX023751 GO:0042281 molecular_function dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity 2 Homo sapiens Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042281 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023752 GO:0042282 molecular_function hydroxymethylglutaryl-CoA reductase activity 1 Homo sapiens Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042282 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023753 GO:0042284 molecular_function sphingolipid delta-4 desaturase activity 2 Homo sapiens Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042284 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023754 GO:0042285 molecular_function xylosyltransferase activity 9 Homo sapiens Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042285 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023755 GO:0042287 molecular_function MHC protein binding 34 Homo sapiens Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042287 PAGER curation team PAGER-contact@googlegroups.com 77.783294606824 2 13-AUG-20 GOA A 21894
TAX023756 GO:0042288 molecular_function MHC class I protein binding 18 Homo sapiens Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042288 PAGER curation team PAGER-contact@googlegroups.com 102.488025135723 2 13-AUG-20 GOA A 21894
TAX023759 GO:0042296 molecular_function ISG15 transferase activity 4 Homo sapiens Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042296 PAGER curation team PAGER-contact@googlegroups.com 282.003028634361 2 13-AUG-20 GOA A 21894
TAX023760 GO:0042297 biological_process vocal learning 7 Homo sapiens A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042297 PAGER curation team PAGER-contact@googlegroups.com 29.3647058823529 2 13-AUG-20 GOA A 21894
TAX023761 GO:0042301 molecular_function phosphate ion binding 9 Homo sapiens Interacting selectively and non-covalently with phosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042301 PAGER curation team PAGER-contact@googlegroups.com 12.2278664731495 2 13-AUG-20 GOA A 21894
TAX023762 GO:0042303 biological_process molting cycle 15 Homo sapiens The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042303 PAGER curation team PAGER-contact@googlegroups.com 6.16998950682057 2 13-AUG-20 GOA A 21894
TAX023763 GO:0042304 biological_process regulation of fatty acid biosynthetic process 43 Homo sapiens Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042304 PAGER curation team PAGER-contact@googlegroups.com 85.2368022657922 2 13-AUG-20 GOA A 21894
TAX023764 GO:0042306 biological_process regulation of protein import into nucleus 64 Homo sapiens Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042306 PAGER curation team PAGER-contact@googlegroups.com 225.809128603472 2 13-AUG-20 GOA A 21894
TAX023765 GO:0042307 biological_process positive regulation of protein import into nucleus 41 Homo sapiens Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042307 PAGER curation team PAGER-contact@googlegroups.com 272.431903049117 2 13-AUG-20 GOA A 21894
TAX023766 GO:0042308 biological_process negative regulation of protein import into nucleus 14 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042308 PAGER curation team PAGER-contact@googlegroups.com 2.90304396843292 2 13-AUG-20 GOA A 21894
TAX023767 GO:0042309 biological_process homoiothermy 2 Homo sapiens Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042309 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023768 GO:0042310 biological_process vasoconstriction 31 Homo sapiens A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042310 PAGER curation team PAGER-contact@googlegroups.com 734.426042948599 2 13-AUG-20 GOA A 21894
TAX023769 GO:0042311 biological_process vasodilation 24 Homo sapiens An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042311 PAGER curation team PAGER-contact@googlegroups.com 434.5174351792 2 13-AUG-20 GOA A 21894
TAX023771 GO:0042316 biological_process penicillin metabolic process 1 Homo sapiens The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042316 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023772 GO:0042320 biological_process regulation of circadian sleep/wake cycle, REM sleep 5 Homo sapiens Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042320 PAGER curation team PAGER-contact@googlegroups.com 151.800928775248 2 13-AUG-20 GOA A 21894
TAX023773 GO:0042321 biological_process negative regulation of circadian sleep/wake cycle, sleep 5 Homo sapiens Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042321 PAGER curation team PAGER-contact@googlegroups.com 124.19795221843 2 13-AUG-20 GOA A 21894
TAX023774 GO:0042322 biological_process negative regulation of circadian sleep/wake cycle, REM sleep 2 Homo sapiens Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042322 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023775 GO:0042323 biological_process negative regulation of circadian sleep/wake cycle, non-REM sleep 2 Homo sapiens Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042323 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023776 GO:0042324 molecular_function hypocretin receptor binding 1 Homo sapiens Interacting selectively and non-covalently with the hypocretin receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042324 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023777 GO:0042325 biological_process regulation of phosphorylation 1465 Homo sapiens Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042325 PAGER curation team PAGER-contact@googlegroups.com 677.908096885804 2 13-AUG-20 GOA A 21894
TAX023778 GO:0042326 biological_process negative regulation of phosphorylation 455 Homo sapiens Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042326 PAGER curation team PAGER-contact@googlegroups.com 162.130515578623 2 13-AUG-20 GOA A 21894
TAX023779 GO:0042327 biological_process positive regulation of phosphorylation 977 Homo sapiens Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042327 PAGER curation team PAGER-contact@googlegroups.com 841.734718005179 2 13-AUG-20 GOA A 21894
TAX023780 GO:0042328 molecular_function heparan sulfate N-acetylglucosaminyltransferase activity 4 Homo sapiens Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042328 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 2 13-AUG-20 GOA A 21894
TAX023781 GO:0042330 biological_process taxis 301 Homo sapiens The directed movement of a motile cell or organism in response to an external stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042330 PAGER curation team PAGER-contact@googlegroups.com 1343.75256984697 2 13-AUG-20 GOA A 21894
TAX023782 GO:0042335 biological_process cuticle development 3 Homo sapiens The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042335 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000660 Paxillin-dependent events mediated by a4b1 19 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 3643.73341634993 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000661 p38 MAPK signaling pathway 17 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 1906.27642438061 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000663 Regulation of Telomerase 61 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=rhoa_reg_pathway&pathway_me=Regulation of RhoA activity&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1921.2505825755 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000664 Regulation of p38-alpha and p38-beta 15 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=rhoa_reg_pathway&pathway_me=Regulation of RhoA activity&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1773.51780608101 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000665 Signaling mediated by p38-gamma and p38-delta 10 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 364.588430437487 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000666 IL6-mediated signaling events 42 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=il6_7pathway&pathway_me=IL6-mediated sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2947.58096887185 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX023784 GO:0042340 biological_process keratan sulfate catabolic process 12 Homo sapiens The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042340 PAGER curation team PAGER-contact@googlegroups.com 688.093612030905 2 13-AUG-20 GOA A 21894
TAX023785 GO:0042350 biological_process GDP-L-fucose biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042350 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX023786 GO:0042351 biological_process 'de novo' GDP-L-fucose biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042351 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023788 GO:0042354 biological_process L-fucose metabolic process 9 Homo sapiens The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042354 PAGER curation team PAGER-contact@googlegroups.com 1213.5641529554 2 13-AUG-20 GOA A 21894
TAX023789 GO:0042355 biological_process L-fucose catabolic process 9 Homo sapiens The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042355 PAGER curation team PAGER-contact@googlegroups.com 1213.5641529554 2 13-AUG-20 GOA A 21894
TAX023791 GO:0042357 biological_process thiamine diphosphate metabolic process 2 Homo sapiens The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042357 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023792 GO:0042359 biological_process vitamin D metabolic process 14 Homo sapiens The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042359 PAGER curation team PAGER-contact@googlegroups.com 261.304694645934 2 13-AUG-20 GOA A 21894
TAX023793 GO:0042360 biological_process vitamin E metabolic process 4 Homo sapiens The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042360 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX023794 GO:0042361 biological_process menaquinone catabolic process 2 Homo sapiens The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042361 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX023795 GO:0042362 biological_process fat-soluble vitamin biosynthetic process 6 Homo sapiens The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042362 PAGER curation team PAGER-contact@googlegroups.com 17.1866295264624 2 13-AUG-20 GOA A 21894
TAX023796 GO:0042363 biological_process fat-soluble vitamin catabolic process 9 Homo sapiens The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042363 PAGER curation team PAGER-contact@googlegroups.com 214.577432010107 2 13-AUG-20 GOA A 21894
TAX023797 GO:0042364 biological_process water-soluble vitamin biosynthetic process 9 Homo sapiens The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042364 PAGER curation team PAGER-contact@googlegroups.com 64.3066914910123 2 13-AUG-20 GOA A 21894
TAX023798 GO:0042365 biological_process water-soluble vitamin catabolic process 2 Homo sapiens The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042365 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000399 Cysteine metabolism 16 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00272 PAGER curation team PAGER-contact@googlegroups.com 1460.32263343457 1.0 13-AUG-20 KEGG P 199
WAG000400 Lysine biosynthesis 20 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00300 PAGER curation team PAGER-contact@googlegroups.com 614.651106160323 1.0 13-AUG-20 KEGG P 199
WAG000401 Primary immunodeficiency 34 Homo sapiens Primary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells such as phagocytes and tural killer (NK) cells. These disorders of the immune system cause increased susceptibility to infection, autoimmune disease, and maligncy. Most of PIs are due to genetic defects that affect cell maturation or function at different levels during hematopoiesis. Disruption of the cellular immunity is observed in patients with defects in T cells or both T and B cells. These cellular immunodeficiencies comprise 20% of all PIs. Disorders of humoral immunity affect B-cell differentiation and antibody production. They account for 70% of all PIs. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05340 PAGER curation team PAGER-contact@googlegroups.com 996.673220843187 1.0 13-AUG-20 KEGG P 199
WAG000402 One carbon pool by folate 16 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00670 PAGER curation team PAGER-contact@googlegroups.com 5139.0756499357 1.0 13-AUG-20 KEGG P 199
WAG000403 Fatty acid elongation in mitochondria 14 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00062 PAGER curation team PAGER-contact@googlegroups.com 1222.96596997055 1.0 13-AUG-20 KEGG P 199
WAG000404 Butanoate metabolism 51 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00650 PAGER curation team PAGER-contact@googlegroups.com 1162.32469461786 1.0 13-AUG-20 KEGG P 199
WAG000405 Keratan sulfate biosynthesis 14 Homo sapiens Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)Glcc(b1-3), with sulfate esters at C-6 of Glcc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00533 PAGER curation team PAGER-contact@googlegroups.com 598.358375164251 1.0 13-AUG-20 KEGG P 199
WAG000406 Nucleotide sugars metabolism 30 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00520 PAGER curation team PAGER-contact@googlegroups.com 359.75086100827 1.0 13-AUG-20 KEGG P 199
WAG000407 Inositol metabolism 2 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00031 PAGER curation team PAGER-contact@googlegroups.com 0.0 1.0 13-AUG-20 KEGG P 199
WAG000408 Geraniol degradation 11 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00281 PAGER curation team PAGER-contact@googlegroups.com 1074.01391061768 1.0 13-AUG-20 KEGG P 199
TAX023799 GO:0042368 biological_process vitamin D biosynthetic process 3 Homo sapiens The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042368 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX023800 GO:0042369 biological_process vitamin D catabolic process 3 Homo sapiens The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042369 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX023801 GO:0042371 biological_process vitamin K biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042371 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX023802 GO:0042373 biological_process vitamin K metabolic process 6 Homo sapiens The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042373 PAGER curation team PAGER-contact@googlegroups.com 63.3983286908078 2 13-AUG-20 GOA A 21894
TAX023803 GO:0042374 biological_process phylloquinone metabolic process 3 Homo sapiens The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042374 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX023804 GO:0042376 biological_process phylloquinone catabolic process 3 Homo sapiens The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0042376 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX030142 GO:0072740 biological_process cellular response to anisomycin 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072740 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030143 GO:0072749 biological_process cellular response to cytochalasin B 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072749 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000187 Prostate cancer 78 Homo sapiens Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-sigling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determints of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Idequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR sigl transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05215 PAGER curation team PAGER-contact@googlegroups.com 3358.13989843394 1.0 13-AUG-20 KEGG P 199
WAG000188 Glutathione metabolism 48 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00480 PAGER curation team PAGER-contact@googlegroups.com 7090.79095853353 1.0 13-AUG-20 KEGG P 199
WAG000195 Cell cycle 100 Homo sapiens Mitotic cell cycle progression is accomplished through a reproducible sequence of events, D replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kises (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and ictivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04110 PAGER curation team PAGER-contact@googlegroups.com 7075.69967780655 1.0 13-AUG-20 KEGG P 199
WAG000196 Type I diabetes mellitus 28 Homo sapiens Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic sigls from APC activate CD4+ T cells, predomintly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma). http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04940 PAGER curation team PAGER-contact@googlegroups.com 1305.86603131476 1.0 13-AUG-20 KEGG P 199
WAG000197 Biosynthesis of steroids 29 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00100 PAGER curation team PAGER-contact@googlegroups.com 1625.19751390656 1.0 13-AUG-20 KEGG P 199
WAG000198 Inositol phosphate metabolism 42 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00562 PAGER curation team PAGER-contact@googlegroups.com 6753.19976919204 1.0 13-AUG-20 KEGG P 199
WAG000199 Sulfur metabolism 23 Homo sapiens Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in sulfate to -2 in sulfide (H2S). Sulfate reduction can occur in both an energy consuming assimilatory pathway and an energy producing dissimilatory pathway. The assimilatory pathway, which is found in a wide range of organisms, produces reduced sulfur compounds for the biosynthesis of S-containing amino acids and does not lead to direct excretion of sulfide. In the dissimilatory pathway, which is restricted to obligatory aerobic bacterial and archaeal lineages, sulfate (or sulfur) is the termil electron acceptor of the respiratory chain producing large quantities of inorganic sulfide. Both pathways start from the activation of sulfate by reaction with ATP to form adenylyl sulfate (APS). In the assimilatory pathway [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00920 PAGER curation team PAGER-contact@googlegroups.com 597.937562845651 1.0 13-AUG-20 KEGG P 199
WAG000200 Gap junction 83 Homo sapiens Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctiol communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctiol applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kises involved in Cx43 and Cx36 phosphorylation. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04540 PAGER curation team PAGER-contact@googlegroups.com 1494.15549867305 1.0 13-AUG-20 KEGG P 199
TAX030005 GO:0072414 biological_process response to mitotic cell cycle checkpoint signaling 1 Homo sapiens A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072414 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000802 N-Glycan degradation 14 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00511 PAGER curation team PAGER-contact@googlegroups.com 260.38799555064 1.0 13-AUG-20 KEGG P 199
TAX030006 GO:0072422 biological_process signal transduction involved in DNA damage checkpoint 70 Homo sapiens A signal transduction process that contributes to a DNA damage checkpoint. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072422 PAGER curation team PAGER-contact@googlegroups.com 1279.91782963396 2 13-AUG-20 GOA A 21894
TAX030007 GO:0072423 biological_process response to DNA damage checkpoint signaling 6 Homo sapiens A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072423 PAGER curation team PAGER-contact@googlegroups.com 109.155904448384 2 13-AUG-20 GOA A 21894
TAX030008 GO:0072425 biological_process signal transduction involved in G2 DNA damage checkpoint 12 Homo sapiens A signal transduction process that contributes to a G2/M transition DNA damage checkpoint. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072425 PAGER curation team PAGER-contact@googlegroups.com 413.421190903238 2 13-AUG-20 GOA A 21894
TAX030009 GO:0072428 biological_process signal transduction involved in intra-S DNA damage checkpoint 1 Homo sapiens A signal transduction process that contributes to an intra-S DNA damage checkpoint. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072428 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030010 GO:0072429 biological_process response to intra-S DNA damage checkpoint signaling 4 Homo sapiens A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072429 PAGER curation team PAGER-contact@googlegroups.com 226.45236784141 2 13-AUG-20 GOA A 21894
TAX030011 GO:0072431 biological_process signal transduction involved in mitotic G1 DNA damage checkpoint 57 Homo sapiens A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072431 PAGER curation team PAGER-contact@googlegroups.com 1149.77877137595 2 13-AUG-20 GOA A 21894
TAX030012 GO:0072432 biological_process response to G1 DNA damage checkpoint signaling 1 Homo sapiens A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072432 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030013 GO:0072434 biological_process signal transduction involved in mitotic G2 DNA damage checkpoint 1 Homo sapiens A signal transduction process that contributes to a mitotic G2/M transition DNA damage checkpoint. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072434 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030014 GO:0072487 cellular_component MSL complex 5 Homo sapiens A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072487 PAGER curation team PAGER-contact@googlegroups.com 490.957645610698 2 13-AUG-20 GOA A 21894
TAX030015 GO:0072488 biological_process ammonium transmembrane transport 16 Homo sapiens The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072488 PAGER curation team PAGER-contact@googlegroups.com 26.6868375716056 2 13-AUG-20 GOA A 21894
TAX030016 GO:0072492 cellular_component host cell mitochondrial intermembrane space 1 Homo sapiens The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072492 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030017 GO:0072498 biological_process embryonic skeletal joint development 5 Homo sapiens The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072498 PAGER curation team PAGER-contact@googlegroups.com 53.7883959044369 2 13-AUG-20 GOA A 21894
TAX030018 GO:0072501 biological_process cellular divalent inorganic anion homeostasis 9 Homo sapiens Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072501 PAGER curation team PAGER-contact@googlegroups.com 93.7232085466675 2 13-AUG-20 GOA A 21894
TAX030019 GO:0072502 biological_process cellular trivalent inorganic anion homeostasis 9 Homo sapiens Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072502 PAGER curation team PAGER-contact@googlegroups.com 93.7232085466675 2 13-AUG-20 GOA A 21894
WAG000803 TGF-beta signaling pathway 83 Homo sapiens The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other D-binding and coactivator (or co-repressor) proteins. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04350 PAGER curation team PAGER-contact@googlegroups.com 2458.31694216168 1.0 13-AUG-20 KEGG P 199
WAG000804 Type II diabetes mellitus 39 Homo sapiens """Insulin resistance is strongly associated with type II diabetes. """"""""Diabetogenic"""""""" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kises (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process.""" http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04930 PAGER curation team PAGER-contact@googlegroups.com 1971.80316795484 1.0 13-AUG-20 KEGG P 199
TAX030020 GO:0072503 biological_process cellular divalent inorganic cation homeostasis 405 Homo sapiens Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072503 PAGER curation team PAGER-contact@googlegroups.com 1266.57158292118 2 13-AUG-20 GOA A 21894
TAX030021 GO:0072505 biological_process divalent inorganic anion homeostasis 14 Homo sapiens Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072505 PAGER curation team PAGER-contact@googlegroups.com 156.012996198458 2 13-AUG-20 GOA A 21894
WAG001066 Trk receptor signaling mediated by the MAPK pathway 25 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=trkrpathway&pathway_me=Neurotrophic%20factor-mediated%20Trk%20receptor%20sigling&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 755.262530757471 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001069 PDGFR-alpha signaling pathway 22 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=pdgfrapathway&pathway_me=PDGFR-alpha sigling pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1606.66246606146 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001070 BARD1 signaling events 26 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=bard1pathway&pathway_me=BARD1 sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3387.54661016686 1.0 13-AUG-20 NCI-Nature Curated P 132
WIG001493 Ethylene Signaling in Arabidopsis 3 Homo sapiens Ethylene Signaling in Arabidopsis http://www.proteinlounge.com/pathway/Ethylene Signaling in Arabidopsis PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 Protein Lounge P 388
TAX030022 GO:0072506 biological_process trivalent inorganic anion homeostasis 14 Homo sapiens Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072506 PAGER curation team PAGER-contact@googlegroups.com 156.012996198458 2 13-AUG-20 GOA A 21894
TAX030023 GO:0072507 biological_process divalent inorganic cation homeostasis 427 Homo sapiens Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072507 PAGER curation team PAGER-contact@googlegroups.com 1140.68111515242 2 13-AUG-20 GOA A 21894
TAX030024 GO:0072509 molecular_function divalent inorganic cation transmembrane transporter activity 26 Homo sapiens Enables the transfer of inorganic cations with a valency of two from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072509 PAGER curation team PAGER-contact@googlegroups.com 318.817164422252 2 13-AUG-20 GOA A 21894
TAX030025 GO:0072510 molecular_function trivalent inorganic cation transmembrane transporter activity 3 Homo sapiens Enables the transfer of inorganic cations with a valency of three from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072510 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX030026 GO:0072511 biological_process divalent inorganic cation transport 286 Homo sapiens The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072511 PAGER curation team PAGER-contact@googlegroups.com 293.779552741721 2 13-AUG-20 GOA A 21894
TAX030027 GO:0072512 biological_process trivalent inorganic cation transport 41 Homo sapiens The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072512 PAGER curation team PAGER-contact@googlegroups.com 4839.20621677467 2 13-AUG-20 GOA A 21894
TAX030028 GO:0072513 biological_process positive regulation of secondary heart field cardioblast proliferation 4 Homo sapiens Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072513 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX030030 GO:0072518 molecular_function Rho-dependent protein serine/threonine kinase activity 1 Homo sapiens Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072518 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030031 GO:0072520 biological_process seminiferous tubule development 11 Homo sapiens The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072520 PAGER curation team PAGER-contact@googlegroups.com 20.6313497822932 2 13-AUG-20 GOA A 21894
GEX001486 serum markers of iron status 14 Homo sapiens serum markers of iron status associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 10.3880856371275 N 1.0 13-AUG-20 GAD G 1671
WAG000206 O-Glycan biosynthesis 24 Homo sapiens O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (Galc) to serine or threonine. The first Galc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additiol four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00512 PAGER curation team PAGER-contact@googlegroups.com 3184.6501022361 1.0 13-AUG-20 KEGG P 199
TAX030144 GO:0072750 biological_process cellular response to leptomycin B 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072750 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030145 GO:0072752 biological_process cellular response to rapamycin 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072752 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030146 GO:0072755 biological_process cellular response to benomyl 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072755 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030147 GO:0072757 biological_process cellular response to camptothecin 4 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072757 PAGER curation team PAGER-contact@googlegroups.com 226.45236784141 2 13-AUG-20 GOA A 21894
TAX030148 GO:0075044 biological_process autophagy of host cells involved in interaction with symbiont 5 Homo sapiens The process in which the host cells digest parts of their own cytoplasm during interaction with its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075044 PAGER curation team PAGER-contact@googlegroups.com 536.008840149947 2 13-AUG-20 GOA A 21894
TAX030149 GO:0075071 biological_process autophagy involved in symbiotic interaction 5 Homo sapiens The process in which cells digest parts of their own cytoplasm during a symbiotic interaction; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075071 PAGER curation team PAGER-contact@googlegroups.com 536.008840149947 2 13-AUG-20 GOA A 21894
TAX030150 GO:0075109 biological_process modulation by symbiont of host receptor-mediated signal transduction 1 Homo sapiens Any process in which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075109 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030151 GO:0075111 biological_process negative regulation by symbiont of host receptor-mediated signal transduction 1 Homo sapiens Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075111 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030152 GO:0075112 biological_process modulation by symbiont of host transmembrane receptor-mediated signal transduction 1 Homo sapiens Any process in which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075112 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030153 GO:0075114 biological_process negative regulation by symbiont of host transmembrane receptor-mediated signal transduction 1 Homo sapiens Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075114 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030154 GO:0075136 biological_process response to host 7 Homo sapiens Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075136 PAGER curation team PAGER-contact@googlegroups.com 12.8588235294118 2 13-AUG-20 GOA A 21894
TAX030155 GO:0075205 biological_process modulation by host of symbiont cAMP-mediated signal transduction 3 Homo sapiens Any process in which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075205 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030156 GO:0075206 biological_process positive regulation by host of symbiont cAMP-mediated signal transduction 3 Homo sapiens Any process in which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075206 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000796 MAPK signaling pathway 233 Homo sapiens The mitogen-activated protein kise (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular sigl-related kises (ERK)-1/2, Jun amino-termil kises (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK siglling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04010 PAGER curation team PAGER-contact@googlegroups.com 2013.07159156347 1.0 13-AUG-20 KEGG P 199
WAG000797 B cell receptor signaling pathway 54 Homo sapiens B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kises (PTKs) -the SRC-family kise LYN, SYK and the TEC-family kise BTK- are activated. Phosphatidylinositol 3-kise (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR siglling. This siglling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04662 PAGER curation team PAGER-contact@googlegroups.com 2599.81973034872 1.0 13-AUG-20 KEGG P 199
WAG000798 Wnt signaling pathway 131 Homo sapiens Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the plar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Plar cell polarity (PCP) sigling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kise JNK (Jun N-termil kise) and ROCK (RHO-associated coiled-coil-containing protein kise 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ siglling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kise PKC (protein kise C) and CAMKII (calcium calmodulin mediated kise II) and the phosphatase calcineurin. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04310 PAGER curation team PAGER-contact@googlegroups.com 2845.21925717726 1.0 13-AUG-20 KEGG P 199
WAG000799 3-Chloroacrylic acid degradation 13 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00641 PAGER curation team PAGER-contact@googlegroups.com 2993.22904655311 1.0 13-AUG-20 KEGG P 199
WAG000800 Epithelial cell signaling in Helicobacter pylori infection 59 Homo sapiens Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA). http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05120 PAGER curation team PAGER-contact@googlegroups.com 1447.37094313819 1.0 13-AUG-20 KEGG P 199
TAX030157 GO:0075341 cellular_component host cell PML body 1 Homo sapiens A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075341 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030158 GO:0075509 biological_process endocytosis involved in viral entry into host cell 3 Homo sapiens Any endocytosis that is involved in the uptake of a virus into a host cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075509 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX030159 GO:0075519 biological_process microtubule-dependent intracellular transport of viral material 1 Homo sapiens The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075519 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030160 GO:0075521 biological_process microtubule-dependent intracellular transport of viral material towards nucleus 1 Homo sapiens The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075521 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030161 GO:0075522 biological_process IRES-dependent viral translational initiation 10 Homo sapiens Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075522 PAGER curation team PAGER-contact@googlegroups.com 395.606881555863 2 13-AUG-20 GOA A 21894
TAX030162 GO:0075525 biological_process viral translational termination-reinitiation 5 Homo sapiens A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075525 PAGER curation team PAGER-contact@googlegroups.com 1216.80585240307 2 13-AUG-20 GOA A 21894
TAX030163 GO:0075528 biological_process modulation by virus of host immune response 2 Homo sapiens The process in which a virus effects a change in the host immune response. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075528 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030164 GO:0075606 biological_process transport of viral material towards nucleus 1 Homo sapiens The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0075606 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX029994 GO:0072385 biological_process minus-end-directed organelle transport along microtubule 4 Homo sapiens The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072385 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 2 13-AUG-20 GOA A 21894
WAG001046 p75(NTR)-mediated signaling 54 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 1581.93967408078 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001047 Signaling mediated by p38-alpha and p38-beta 31 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 477.196826407496 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001048 Regulation of nuclear SMAD2/3 signaling 69 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=rhoa_reg_pathway&pathway_me=Regulation of RhoA activity&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2656.3835084849 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001049 Syndecan-4-mediated signaling events 32 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=syndecan_pathway&pathway_me=Proteoglycan%20syndecan-mediated%20sigling%20events&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1150.39863843128 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001050 LPA receptor mediated events 46 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=lysophospholipid_pathway&pathway_me=LPA receptor mediated events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3601.12363077294 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001051 Signaling events mediated by HDAC Class I 48 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 2418.82436980817 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001052 Fc-epsilon receptor I signaling in mast cells 61 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=fcer1pathway&pathway_me=Fc-epsilon receptor I sigling in mast cells&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 4956.51805223166 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001053 Presenilin action in Notch and Wnt signaling 42 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=ps1pathway&pathway_me=Presenilin action in Notch and Wnt sigling&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1860.61328707736 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001054 EPHB forward signaling 33 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=ephrinb_ephbpathway&pathway_me=EphrinB-EPHB%20pathway&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3871.41243346626 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001055 FoxO family signaling 28 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=foxopathway&pathway_me=FoxO family sigling&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1209.24263017651 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001056 Sphingosine 1-phosphate (S1P) pathway 9 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 948.58635449067 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001057 IL2 signaling events mediated by STAT5 28 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 3790.30067146927 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001058 Aurora A signaling 29 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=aurora_kise_pathway&pathway_me=Sigling%20by%20Aurora%20kises&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 747.554448742568 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001059 a6b1 and a6b4 Integrin signaling 24 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 3587.9402562307 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001060 Role of Calcineurin-dependent NFAT signaling in lymphocytes 33 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 954.411751443993 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001061 Aurora B signaling 37 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=aurora_b_pathway&pathway_me=Aurora%20B%20sigling&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2338.96263132663 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001062 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 45 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 1937.86769467535 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001063 Trk receptor signaling mediated by PI3K and PLC-gamma 26 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 2104.09303774865 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001064 EPHA forward signaling 14 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=ephri_ephapathway&pathway_me=Ephri-EPHA%20pathway&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 945.438427024678 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000202 Nitrogen metabolism 32 Homo sapiens The biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in nitrate to -3 in ammonia. The core nitrogen cycle involves four reduction pathways and two oxidation pathways. Nitrogen fixation [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00910 PAGER curation team PAGER-contact@googlegroups.com 1491.86406086843 1.0 13-AUG-20 KEGG P 199
TAX029995 GO:0072386 biological_process plus-end-directed organelle transport along microtubule 8 Homo sapiens The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072386 PAGER curation team PAGER-contact@googlegroups.com 594.365302417194 2 13-AUG-20 GOA A 21894
WAG000201 Arachidonic acid metabolism 51 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00590 PAGER curation team PAGER-contact@googlegroups.com 6653.48977090408 1.0 13-AUG-20 KEGG P 199
WAG000204 Mismatch repair 21 Homo sapiens D mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects D mismatches generated during D replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombition and was recently shown to play a role in D damage sigling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03430 PAGER curation team PAGER-contact@googlegroups.com 5816.89801744397 1.0 13-AUG-20 KEGG P 199
WAG000205 D-Arginine and D-ornithine metabolism 8 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00472 PAGER curation team PAGER-contact@googlegroups.com 1536.33005949191 1.0 13-AUG-20 KEGG P 199
WAG000189 Olfactory transduction 295 Homo sapiens Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical sigl that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert ictive forms of protein kise A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04740 PAGER curation team PAGER-contact@googlegroups.com 55652.6010121786 1.0 13-AUG-20 KEGG P 199
WAG000190 Tight junction 118 Homo sapiens Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctiol adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. The transmembrane proteins mediate cell adhesion and are thought to constitute the intramembrane and paracellular diffusion barriers. The cytoplasmic 'plaque' contains three major multi-protein complexes consisting largely of scaffolding proteins, the ZO protein complex, the CRB3-Pals1-PATJ complex and the PAR-3-aPKC-PAR-6 complex. The ZO protein complex appears to organize the transmembrane proteins and couple them to other cytoplasmic proteins and to actin microfilaments. Two evolutiorily conserved protein complexes, the CRB3 and PAR complexes are involved in the establishment and maintence of epithelial cell polarity. Besides these three protein complexes which seem to be constitutively associated at TJs, a number of proteins with different functions has been identified at TJs. These include additiol scaffolding proteins like MUPP1 and MAGI-1, adaptor proteins, transcription regulators and R processing factors, regulatory proteins like small GTPases and G-proteins, kises and phosphatases, and heat shock proteins. These are proposed to be involved in junction assembly, barrier regulation, gene transcription, and perhaps other, presently undefined pathways. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04530 PAGER curation team PAGER-contact@googlegroups.com 1549.38883658156 1.0 13-AUG-20 KEGG P 199
WAG000191 Alzheimer's disease 49 Homo sapiens Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Altertively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal domint or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05010 PAGER curation team PAGER-contact@googlegroups.com 956.904372718915 1.0 13-AUG-20 KEGG P 199
TAX029996 GO:0072387 biological_process flavin adenine dinucleotide metabolic process 2 Homo sapiens The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072387 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX029997 GO:0072388 biological_process flavin adenine dinucleotide biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072388 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX029998 GO:0072389 biological_process flavin adenine dinucleotide catabolic process 1 Homo sapiens The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072389 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX029999 GO:0072393 biological_process microtubule anchoring at microtubule organizing center 11 Homo sapiens Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072393 PAGER curation team PAGER-contact@googlegroups.com 127.163591125855 2 13-AUG-20 GOA A 21894
TAX030000 GO:0072395 biological_process signal transduction involved in cell cycle checkpoint 71 Homo sapiens A signal transduction process that contributes to a cell cycle checkpoint. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072395 PAGER curation team PAGER-contact@googlegroups.com 1245.70896485921 2 13-AUG-20 GOA A 21894
TAX030001 GO:0072396 biological_process response to cell cycle checkpoint signaling 6 Homo sapiens A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072396 PAGER curation team PAGER-contact@googlegroups.com 109.155904448384 2 13-AUG-20 GOA A 21894
TAX030002 GO:0072401 biological_process signal transduction involved in DNA integrity checkpoint 70 Homo sapiens A signal transduction process that contributes to a DNA integrity checkpoint. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072401 PAGER curation team PAGER-contact@googlegroups.com 1279.91782963396 2 13-AUG-20 GOA A 21894
TAX030003 GO:0072402 biological_process response to DNA integrity checkpoint signaling 6 Homo sapiens A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072402 PAGER curation team PAGER-contact@googlegroups.com 109.155904448384 2 13-AUG-20 GOA A 21894
TAX030082 GO:0072594 biological_process establishment of protein localization to organelle 356 Homo sapiens The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072594 PAGER curation team PAGER-contact@googlegroups.com 3312.98894166947 2 13-AUG-20 GOA A 21894
TAX030083 GO:0072595 biological_process maintenance of protein localization in organelle 37 Homo sapiens Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072595 PAGER curation team PAGER-contact@googlegroups.com 64.3924422159716 2 13-AUG-20 GOA A 21894
TAX030084 GO:0072599 biological_process establishment of protein localization to endoplasmic reticulum 103 Homo sapiens The directed movement of a protein to a specific location in the endoplasmic reticulum. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072599 PAGER curation team PAGER-contact@googlegroups.com 40521.1376309462 2 13-AUG-20 GOA A 21894
TAX030086 GO:0072604 biological_process interleukin-6 secretion 2 Homo sapiens The regulated release of interleukin-6 from a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072604 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030087 GO:0072606 biological_process interleukin-8 secretion 4 Homo sapiens The regulated release of interleukin-8 from a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072606 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX030088 GO:0072608 biological_process interleukin-10 secretion 1 Homo sapiens The regulated release of interleukin-10 from a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072608 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030089 GO:0072610 biological_process interleukin-12 secretion 2 Homo sapiens The regulated release of interleukin-12 from a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072610 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030090 GO:0072615 biological_process interleukin-17 secretion 2 Homo sapiens The regulated release of any member of the interleukin-17 family of cytokines from a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072615 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030091 GO:0072616 biological_process interleukin-18 secretion 1 Homo sapiens The regulated release of interleukin-18 from a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072616 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030092 GO:0072619 biological_process interleukin-21 secretion 1 Homo sapiens The regulated release of interleukin-21 from a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072619 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030093 GO:0072643 biological_process interferon-gamma secretion 7 Homo sapiens The regulated release of interferon-gamma from a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072643 PAGER curation team PAGER-contact@googlegroups.com 12.8588235294118 2 13-AUG-20 GOA A 21894
TAX030094 GO:0072655 biological_process establishment of protein localization to mitochondrion 62 Homo sapiens The directed movement of a protein to the mitochondrion or a part of the mitochondrion. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072655 PAGER curation team PAGER-contact@googlegroups.com 1069.87218601538 2 13-AUG-20 GOA A 21894
TAX030095 GO:0072656 biological_process maintenance of protein location in mitochondrion 5 Homo sapiens Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072656 PAGER curation team PAGER-contact@googlegroups.com 340.449448889386 2 13-AUG-20 GOA A 21894
TAX030096 GO:0072657 biological_process protein localization to membrane 404 Homo sapiens A process in which a protein is transported to, or maintained in, a specific location in a membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072657 PAGER curation team PAGER-contact@googlegroups.com 2054.24792661972 2 13-AUG-20 GOA A 21894
TAX030097 GO:0072658 biological_process maintenance of protein location in membrane 1 Homo sapiens Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072658 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030098 GO:0072659 biological_process protein localization to plasma membrane 157 Homo sapiens A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072659 PAGER curation team PAGER-contact@googlegroups.com 41.8757983818388 2 13-AUG-20 GOA A 21894
WAG000601 Parkinson's disease 15 Homo sapiens Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-interlized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neurol death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, syptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformatiol transition could lead to the lost of a beneficial activity of the tively folded protein, PrPC. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05020 PAGER curation team PAGER-contact@googlegroups.com 382.602857136814 1.0 13-AUG-20 KEGG P 199
WAG000602 Hematopoietic cell lineage 80 Homo sapiens Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the tural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04640 PAGER curation team PAGER-contact@googlegroups.com 3751.06908892394 1.0 13-AUG-20 KEGG P 199
WAG000603 GnRH signaling pathway 86 Homo sapiens Godotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the godotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its sigl to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kise C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasiolly observed in a cell-specific fashion. Sigling downstream of protein kise C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kises (MAPKs), including extracellular-sigl-regulated kise (ERK), Jun N-termil kise (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04912 PAGER curation team PAGER-contact@googlegroups.com 2622.13045001693 1.0 13-AUG-20 KEGG P 199
WAG000604 Glycan structures - biosynthesis 1 104 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa01030 PAGER curation team PAGER-contact@googlegroups.com 480.954609125769 1.0 13-AUG-20 KEGG P 199
WAG000605 Biosynthesis of unsaturated fatty acids 21 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa01040 PAGER curation team PAGER-contact@googlegroups.com 278.089822177435 1.0 13-AUG-20 KEGG P 199
WAG000446 Reelin signaling pathway 27 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=reelinpathway&pathway_me=Reelin sigling pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2108.18489474243 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000449 p38 signaling mediated by MAPKAP kinases 14 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=p38_mkk3_6pathway&pathway_me=p38%20MAPK%20sigling%20pathway&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 733.291212998781 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000450 S1P1 pathway 12 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 1712.63815305372 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX030099 GO:0072660 biological_process maintenance of protein location in plasma membrane 1 Homo sapiens Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072660 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030100 GO:0072662 biological_process protein localization to peroxisome 67 Homo sapiens A process in which a protein is transported to, or maintained at, a location in a peroxisome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072662 PAGER curation team PAGER-contact@googlegroups.com 1191.43849638633 2 13-AUG-20 GOA A 21894
TAX030101 GO:0072663 biological_process establishment of protein localization to peroxisome 67 Homo sapiens The directed movement of a protein to a specific location in a peroxisome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072663 PAGER curation team PAGER-contact@googlegroups.com 1191.43849638633 2 13-AUG-20 GOA A 21894
TAX030102 GO:0072665 biological_process protein localization to vacuole 42 Homo sapiens A process in which a protein is transported to, or maintained at, a location in a vacuole. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072665 PAGER curation team PAGER-contact@googlegroups.com 74.1202436942431 2 13-AUG-20 GOA A 21894
TAX030103 GO:0072666 biological_process establishment of protein localization to vacuole 30 Homo sapiens The directed movement of a protein to a specific location in a vacuole. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072666 PAGER curation team PAGER-contact@googlegroups.com 127.511993253627 2 13-AUG-20 GOA A 21894
WAG000451 Glypican 3 network 6 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=glypicanpathway&pathway_me=Glypican pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 362.270792887088 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX030104 GO:0072669 cellular_component tRNA-splicing ligase complex 7 Homo sapiens A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072669 PAGER curation team PAGER-contact@googlegroups.com 80.2818161110516 2 13-AUG-20 GOA A 21894
TAX030105 GO:0072671 biological_process mitochondria-associated ubiquitin-dependent protein catabolic process 1 Homo sapiens The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072671 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030106 GO:0072672 biological_process neutrophil extravasation 6 Homo sapiens The migration of a neutrophil from the blood vessels into the surrounding tissue. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072672 PAGER curation team PAGER-contact@googlegroups.com 17.1866295264624 2 13-AUG-20 GOA A 21894
TAX030107 GO:0072673 biological_process lamellipodium morphogenesis 6 Homo sapiens A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072673 PAGER curation team PAGER-contact@googlegroups.com 135.910779100194 2 13-AUG-20 GOA A 21894
TAX030108 GO:0072674 biological_process multinuclear osteoclast differentiation 2 Homo sapiens The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072674 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030109 GO:0072675 biological_process osteoclast fusion 5 Homo sapiens The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072675 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030110 GO:0072676 biological_process lymphocyte migration 57 Homo sapiens The movement of a lymphocyte within or between different tissues and organs of the body. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072676 PAGER curation team PAGER-contact@googlegroups.com 2473.77520283557 2 13-AUG-20 GOA A 21894
TAX030111 GO:0072677 biological_process eosinophil migration 10 Homo sapiens The movement of an eosinophil within or between different tissues and organs of the body. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072677 PAGER curation team PAGER-contact@googlegroups.com 697.79062301691 2 13-AUG-20 GOA A 21894
TAX030112 GO:0072678 biological_process T cell migration 22 Homo sapiens The movement of a T cell within or between different tissues and organs of the body. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072678 PAGER curation team PAGER-contact@googlegroups.com 1096.06320599871 2 13-AUG-20 GOA A 21894
TAX030113 GO:0072679 biological_process thymocyte migration 2 Homo sapiens The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072679 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030114 GO:0072683 biological_process T cell extravasation 2 Homo sapiens The migration of a T cell from the blood vessels into the surrounding tissue. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072683 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030115 GO:0072684 biological_process mitochondrial tRNA 3'-trailer cleavage, endonucleolytic 1 Homo sapiens Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072684 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030116 GO:0072686 cellular_component mitotic spindle 63 Homo sapiens A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072686 PAGER curation team PAGER-contact@googlegroups.com 297.025903526115 2 13-AUG-20 GOA A 21894
TAX030117 GO:0072687 cellular_component meiotic spindle 8 Homo sapiens A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072687 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030118 GO:0072695 biological_process regulation of DNA recombination at telomere 2 Homo sapiens Any process that modulates the frequency, rate or extent of DNA recombination within the telomere. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072695 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030119 GO:0072697 biological_process protein localization to cell cortex 2 Homo sapiens A process in which a protein is transported to, or maintained in, the cell cortex. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072697 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030120 GO:0072698 biological_process protein localization to microtubule cytoskeleton 31 Homo sapiens A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072698 PAGER curation team PAGER-contact@googlegroups.com 74.8643332667243 2 13-AUG-20 GOA A 21894
TAX030121 GO:0072702 biological_process response to methyl methanesulfonate 1 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072702 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030122 GO:0072703 biological_process cellular response to methyl methanesulfonate 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072703 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030123 GO:0072706 biological_process response to sodium dodecyl sulfate 1 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072706 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030124 GO:0072707 biological_process cellular response to sodium dodecyl sulfate 1 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072707 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
GEX000630 end-stage renal disease 2 Homo sapiens end-stage renal disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001103 menopause 49 Homo sapiens menopause associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.02059708850256 N 1.0 13-AUG-20 GAD G 1671
GEX001582 thyroid neoplasms 4 Homo sapiens thyroid neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001137 mucocutaneous lymph node syndrome 18 Homo sapiens mucocutaneous lymph node syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.0639127045986 N 1.0 13-AUG-20 GAD G 1671
GEX001190 neutrophil count 3 Homo sapiens neutrophil count associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000237 biomedical quantitative traits 5 Homo sapiens biomedical quantitative traits associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000737 glaucoma 7 Homo sapiens glaucoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 22.9022403258656 N 1.0 13-AUG-20 GAD G 1671
FAX000518 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNWAAAYAAAYANNNNN which matches annotation for FOXJ2: forkhead box J2 168 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNWAAAYAAAYANNNNN which matches annotation for FOXJ2: forkhead box J2 http://www.broadinstitute.org/gsea/msigdb/cards/V$FOXJ2_01 M13325 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.25427951615228 N 1.0 13-AUG-20 MSigDB A 13229
FAX000648 Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NGGGGAMTTTCCNN. Motif does not match any known transcription factor 244 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing motif NGGGGAMTTTCCNN. Motif does not match any known transcription factor http://www.broadinstitute.org/gsea/msigdb/cards/V$NFKB_Q6 M11921 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 32.0952426837727 N 1.0 13-AUG-20 MSigDB A 13229
FAX000694 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNTTCACGCWTGANTKNNN which matches annotation for PAX6: paired box gene 6 (aniridia, keratitis) 91 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNNTTCACGCWTGANTKNNN which matches annotation for PAX6: paired box gene 6 (aniridia, keratitis) http://www.broadinstitute.org/gsea/msigdb/cards/V$PAX6_01 M17373 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 1.75810103866185 N 1.0 13-AUG-20 MSigDB A 13229
FAX000771 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif STATAAAWRNNNNNN which matches annotation for TAF
TATA 241 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif STATAAAWRNNNNNN which matches annotation for TAF
TATA http://www.broadinstitute.org/gsea/msigdb/cards/V$TATA_01 M3150 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 19.8285497726488 N 1.0 13-AUG-20 MSigDB A 13229
WIG001424 Actin Nucleation and Branching 101 Homo sapiens Actin Nucleation and Branching http://www.proteinlounge.com/pathway/Actin Nucleation and Branching PAGER curation team PAGER-contact@googlegroups.com CURRENT 130.26140759989 N 1.0 13-AUG-20 Protein Lounge P 388
WAG000820 Glioma 53 Homo sapiens Gliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predomintly of astrocytes (astrocytomas), oligodendrocytes (oligodendrogliomas), mixtures of various glial cells (for example,oligoastrocytomas) and ependymal cells (ependymomas). The most malignt form of infiltrating astrocytoma - glioblastoma multiforme (GBM) - is one of the most aggressive human cancers. GBM may develop de novo (primary glioblastoma) or by progression from low-grade or aplastic astrocytoma (secondary glioblastoma). Primary glioblastomas develop in older patients and typically show genetic alterations (EGFR amplification, p16/INK4a deletion, and PTEN mutations) at frequencies of 24-34%. Secondary glioblastomas develop in younger patients and frequently show overexpression of PDGF and CDK4 as well as p53 mutations (65%) and loss of Rb playing major roles in such transformations. Loss of PTEN has been implicated in both pathways, although it is much more common in the pathogenesis of primary GBM. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05214 PAGER curation team PAGER-contact@googlegroups.com 4498.10685835938 1.0 13-AUG-20 KEGG P 199
WAG000821 Urea cycle and metabolism of amino groups 26 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00220 PAGER curation team PAGER-contact@googlegroups.com 787.535650305313 1.0 13-AUG-20 KEGG P 199
WAG000822 Bisphenol A degradation 4 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00363 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 1.0 13-AUG-20 KEGG P 199
WAG000823 Prion diseases 11 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05060 PAGER curation team PAGER-contact@googlegroups.com 454.659491451944 1.0 13-AUG-20 KEGG P 199
TAX031524 GO:0102751 molecular_function UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity 2 Homo sapiens Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102751 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX031525 GO:0102752 molecular_function 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) 1 Homo sapiens Catalysis of the reaction: a glucosylated glycogenin = a glycogen http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102752 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031526 GO:0102756 molecular_function very-long-chain 3-ketoacyl-CoA synthase activity 7 Homo sapiens Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102756 PAGER curation team PAGER-contact@googlegroups.com 185.042537578412 2 13-AUG-20 GOA A 21894
TAX031527 GO:0102758 molecular_function very-long-chain enoyl-CoA reductase activity 1 Homo sapiens Catalysis of the reaction: NADP(3-) + a very-long-chain 2,3,4-saturated fatty acyl CoA <=> NADPH(4-) + H+ + a very-long-chain trans-2,3-dehydroacyl-CoA http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102758 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031528 GO:0102769 molecular_function dihydroceramide glucosyltransferase activity 1 Homo sapiens Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102769 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031529 GO:0102773 molecular_function dihydroceramide kinase activity 1 Homo sapiens Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102773 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031530 GO:0102797 molecular_function geranial:oxygen oxidoreductase activity 1 Homo sapiens Catalysis of the reaction: geranial + O2 + H2O = H+ + geranate + hydrogen peroxide http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102797 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031531 GO:0102798 molecular_function heptaldehyde:oxygen oxidoreductase activity 1 Homo sapiens Catalysis of the reaction: heptanal + O2 + H2O = H+ + heptanoate + hydrogen peroxide http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102798 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031532 GO:0102867 molecular_function molybdenum cofactor sulfurtransferase activity 1 Homo sapiens Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102867 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
GEX000078 alzheimer's disease 120 Homo sapiens alzheimer's disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 409.77818170122 N 1.0 13-AUG-20 GAD G 1671
GEX001043 lupus erythematosus 34 Homo sapiens lupus erythematosus associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 139.540879223135 N 1.0 13-AUG-20 GAD G 1671
GEX001522 speech perception in dyslexia 3 Homo sapiens speech perception in dyslexia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000096 aneurysm, abdominal aortic 3 Homo sapiens aneurysm, abdominal aortic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001559 tacrolimus pharmacokinetics 3 Homo sapiens tacrolimus pharmacokinetics associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 GAD G 1671
TAX030032 GO:0072521 biological_process purine-containing compound metabolic process 388 Homo sapiens The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072521 PAGER curation team PAGER-contact@googlegroups.com 490.80559035867 2 13-AUG-20 GOA A 21894
TAX030033 GO:0072522 biological_process purine-containing compound biosynthetic process 192 Homo sapiens The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072522 PAGER curation team PAGER-contact@googlegroups.com 655.891713713085 2 13-AUG-20 GOA A 21894
TAX030034 GO:0072523 biological_process purine-containing compound catabolic process 51 Homo sapiens The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072523 PAGER curation team PAGER-contact@googlegroups.com 1830.26554553262 2 13-AUG-20 GOA A 21894
TAX030035 GO:0072524 biological_process pyridine-containing compound metabolic process 115 Homo sapiens The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072524 PAGER curation team PAGER-contact@googlegroups.com 1152.56720611591 2 13-AUG-20 GOA A 21894
TAX030036 GO:0072525 biological_process pyridine-containing compound biosynthetic process 73 Homo sapiens The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072525 PAGER curation team PAGER-contact@googlegroups.com 942.499595607529 2 13-AUG-20 GOA A 21894
TAX030037 GO:0072526 biological_process pyridine-containing compound catabolic process 6 Homo sapiens The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072526 PAGER curation team PAGER-contact@googlegroups.com 48.1647058823529 2 13-AUG-20 GOA A 21894
TAX030038 GO:0072527 biological_process pyrimidine-containing compound metabolic process 94 Homo sapiens The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072527 PAGER curation team PAGER-contact@googlegroups.com 545.998584950577 2 13-AUG-20 GOA A 21894
TAX030039 GO:0072528 biological_process pyrimidine-containing compound biosynthetic process 54 Homo sapiens The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072528 PAGER curation team PAGER-contact@googlegroups.com 759.536225680956 2 13-AUG-20 GOA A 21894
TAX030040 GO:0072529 biological_process pyrimidine-containing compound catabolic process 34 Homo sapiens The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072529 PAGER curation team PAGER-contact@googlegroups.com 366.64773751862 2 13-AUG-20 GOA A 21894
TAX030041 GO:0072530 biological_process purine-containing compound transmembrane transport 8 Homo sapiens The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072530 PAGER curation team PAGER-contact@googlegroups.com 9.91853360488798 2 13-AUG-20 GOA A 21894
WAG000207 Amyotrophic lateral sclerosis (ALS) 13 Homo sapiens """Drug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic system that projects from the ventral tegmental area (VTA) of the midbrain to the nucleus accumbens (c), and to other forebrain sites, is the major substrate of reward and reinforcement for both tural rewards and addictive drugs. Cocaine binds strongly to the dopamine-reuptake transporter, preventing the reuptake of dopamine into the nerve termil. Because of this blocking effect, dopamine remains at high concentrations in the sypse and continues to affect adjacent neurons, producing the characteristic cocaine """"""""high."""""""" Activated D1 receptor activates the PKA sigling pathway, and this pathway plays a critical role in mediating the behavioral responses to cocaine administration. Cocaine-induced neuroadaptations, including dopamine depletion, may underlie craving and hedonic dysregulation.""" http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05030 PAGER curation team PAGER-contact@googlegroups.com 365.27178788337 1.0 13-AUG-20 KEGG P 199
WAG000208 Regulation of autophagy 28 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04140 PAGER curation team PAGER-contact@googlegroups.com 934.989331744319 1.0 13-AUG-20 KEGG P 199
WAG000209 Monoterpenoid biosynthesis 3 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00902 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 1.0 13-AUG-20 KEGG P 199
WAG000210 Caprolactam degradation 6 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00930 PAGER curation team PAGER-contact@googlegroups.com 507.274309951887 1.0 13-AUG-20 KEGG P 199
TAX030042 GO:0072531 biological_process pyrimidine-containing compound transmembrane transport 9 Homo sapiens The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072531 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030043 GO:0072534 cellular_component perineuronal net 2 Homo sapiens A dense extracellular matrix (ECM) structure that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072534 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030044 GO:0072536 cellular_component interleukin-23 receptor complex 2 Homo sapiens A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072536 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030045 GO:0072537 biological_process fibroblast activation 4 Homo sapiens A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072537 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX030046 GO:0072539 biological_process T-helper 17 cell differentiation 3 Homo sapiens The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072539 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX030047 GO:0072540 biological_process T-helper 17 cell lineage commitment 6 Homo sapiens The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072540 PAGER curation team PAGER-contact@googlegroups.com 63.3983286908078 2 13-AUG-20 GOA A 21894
TAX030048 GO:0072542 molecular_function protein phosphatase activator activity 8 Homo sapiens Increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072542 PAGER curation team PAGER-contact@googlegroups.com 22.9022403258656 2 13-AUG-20 GOA A 21894
TAX030049 GO:0072544 molecular_function L-DOPA binding 1 Homo sapiens Interacting selectively and non-covalently with L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072544 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030050 GO:0072545 molecular_function tyrosine binding 2 Homo sapiens Interacting selectively and non-covalently with2-amino-3-(4-hydroxyphenyl)propanoic acid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072545 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030051 GO:0072546 cellular_component ER membrane protein complex 10 Homo sapiens A transmembrane protein complex located in the ER that is involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072546 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030052 GO:0072553 biological_process terminal button organization 3 Homo sapiens A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072553 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX030053 GO:0072554 biological_process blood vessel lumenization 2 Homo sapiens The process in which a developing blood vessel forms an endothelial lumen through which blood will flow. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072554 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX030054 GO:0072555 molecular_function 17-beta-ketosteroid reductase activity 1 Homo sapiens Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072555 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030056 GO:0072557 cellular_component IPAF inflammasome complex 5 Homo sapiens A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072557 PAGER curation team PAGER-contact@googlegroups.com 188.558607956135 2 13-AUG-20 GOA A 21894
TAX030057 GO:0072558 cellular_component NLRP1 inflammasome complex 4 Homo sapiens A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072558 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 2 13-AUG-20 GOA A 21894
TAX030058 GO:0072559 cellular_component NLRP3 inflammasome complex 9 Homo sapiens A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072559 PAGER curation team PAGER-contact@googlegroups.com 505.218850741159 2 13-AUG-20 GOA A 21894
TAX030059 GO:0072560 biological_process type B pancreatic cell maturation 2 Homo sapiens A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072560 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030060 GO:0072562 cellular_component blood microparticle 191 Homo sapiens A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072562 PAGER curation team PAGER-contact@googlegroups.com 322.95099418913 2 13-AUG-20 GOA A 21894
TAX030061 GO:0072563 cellular_component endothelial microparticle 2 Homo sapiens A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072563 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030062 GO:0072570 molecular_function ADP-D-ribose binding 1 Homo sapiens Interacting selectively and non-covalently with ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072570 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030063 GO:0072572 molecular_function poly-ADP-D-ribose binding 1 Homo sapiens Interacting selectively and non-covalently with polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072572 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030064 GO:0072573 biological_process tolerance induction to lipopolysaccharide 2 Homo sapiens Tolerance induction directed at lipopolysaccharide antigens. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072573 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030065 GO:0072574 biological_process hepatocyte proliferation 3 Homo sapiens The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072574 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX030066 GO:0072575 biological_process epithelial cell proliferation involved in liver morphogenesis 3 Homo sapiens The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072575 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX030067 GO:0072576 biological_process liver morphogenesis 1 Homo sapiens The process in which the anatomical structures of the liver are generated and organized. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072576 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030068 GO:0072577 biological_process endothelial cell apoptotic process 8 Homo sapiens Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072577 PAGER curation team PAGER-contact@googlegroups.com 97.766541161968 2 13-AUG-20 GOA A 21894
TAX030069 GO:0072578 biological_process neurotransmitter-gated ion channel clustering 7 Homo sapiens The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072578 PAGER curation team PAGER-contact@googlegroups.com 147.829257900343 2 13-AUG-20 GOA A 21894
TAX030070 GO:0072579 biological_process glycine receptor clustering 1 Homo sapiens The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072579 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030071 GO:0072582 molecular_function 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1 Homo sapiens Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072582 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030072 GO:0072583 biological_process clathrin-dependent endocytosis 24 Homo sapiens An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072583 PAGER curation team PAGER-contact@googlegroups.com 1044.89433985514 2 13-AUG-20 GOA A 21894
TAX030073 GO:0072584 biological_process caveolin-mediated endocytosis 5 Homo sapiens An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072584 PAGER curation team PAGER-contact@googlegroups.com 188.558607956135 2 13-AUG-20 GOA A 21894
TAX030075 GO:0072587 molecular_function DNA topoisomerase (ATP-hydrolyzing) activator activity 1 Homo sapiens Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072587 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030076 GO:0072588 cellular_component box H/ACA RNP complex 6 Homo sapiens A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072588 PAGER curation team PAGER-contact@googlegroups.com 841.135695394052 2 13-AUG-20 GOA A 21894
GEX000291 bone density fractures, vertebral 3 Homo sapiens bone density fractures, vertebral associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX001242 osteosarcoma 2 Homo sapiens osteosarcoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000323 breast cancer, male 3 Homo sapiens breast cancer, male associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000814 hepatitis b 16 Homo sapiens hepatitis b associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1129.56104753223 N 1.0 13-AUG-20 GAD G 1671
GEX001270 pancreatitis, chronic 4 Homo sapiens pancreatitis, chronic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 23.9931740614334 N 1.0 13-AUG-20 GAD G 1671
GEX000352 carcinoma, squamous cell|mouth neoplasms 2 Homo sapiens carcinoma, squamous cell|mouth neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000390 cerebrum 2 Homo sapiens cerebrum associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000433 chronic pancreatitis 2 Homo sapiens chronic pancreatitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000951 ischemia 2 Homo sapiens ischemia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001420 respiratory distress syndrome 2 Homo sapiens respiratory distress syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000987 leprosy, lepromatous 2 Homo sapiens leprosy, lepromatous associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000039 aging and longevity 2 Homo sapiens aging and longevity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000524 crohn's disease ulcerative colitis 15 Homo sapiens crohn's disease ulcerative colitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 163.893341400162 N 1.0 13-AUG-20 GAD G 1671
TAX030077 GO:0072589 cellular_component box H/ACA scaRNP complex 4 Homo sapiens A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072589 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 2 13-AUG-20 GOA A 21894
TAX030078 GO:0072590 molecular_function N-acetyl-L-aspartate-L-glutamate ligase activity 2 Homo sapiens Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072590 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030079 GO:0072591 molecular_function citrate-L-glutamate ligase activity 1 Homo sapiens Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072591 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030080 GO:0072592 biological_process oxygen metabolic process 3 Homo sapiens The chemical reactions and pathways involving diatomic oxygen (O2). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072592 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX030081 GO:0072593 biological_process reactive oxygen species metabolic process 99 Homo sapiens The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0072593 PAGER curation team PAGER-contact@googlegroups.com 180.835743259216 2 13-AUG-20 GOA A 21894
WAG000437 FOXM1 transcription factor network 35 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=foxm1pathway&pathway_me=FOXM1 transcription factor network&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2449.83514736456 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000438 Signaling events mediated by HDAC Class II 33 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 1536.27559738664 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000439 S1P4 pathway 7 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 1097.07937033969 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000440 PDGFR-beta signaling pathway 38 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=pdgfrbpathway&pathway_me=PDGFR-beta sigling pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3979.61217920142 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000441 Signaling events mediated by PTP1B 43 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 3841.30503252055 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000443 Signaling by Aurora kinases 3 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000444 Atypical NF-kappaB pathway 14 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=nfkappabatypicalpathway&pathway_me=Atypical NF-kappaB pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2405.74111834008 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX031534 GO:0102953 molecular_function hypoglycin A gamma-glutamyl transpeptidase activity 5 Homo sapiens Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102953 PAGER curation team PAGER-contact@googlegroups.com 53.7883959044369 2 13-AUG-20 GOA A 21894
TAX031535 GO:0102965 molecular_function alcohol-forming fatty acyl-CoA reductase activity 2 Homo sapiens Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102965 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031536 GO:0102966 molecular_function arachidoyl-CoA:1-dodecanol O-acyltransferase activity 2 Homo sapiens Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102966 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031537 GO:0102991 molecular_function myristoyl-CoA hydrolase activity 7 Homo sapiens Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102991 PAGER curation team PAGER-contact@googlegroups.com 9.91853360488798 2 13-AUG-20 GOA A 21894
TAX031539 GO:0103025 molecular_function alpha-amylase activity (releasing maltohexaose) 3 Homo sapiens Catalysis of the reaction: n H2O + a 1,4-alpha-D-glucan = alpha-maltohexaose + a 1,4-alpha-D-glucan http://amigo.geneontology.org/amigo/search/ontology?q=GO:0103025 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031540 GO:0103045 molecular_function methione N-acyltransferase activity 1 Homo sapiens Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0103045 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031541 GO:0103046 molecular_function alanylglutamate dipeptidase activity 1 Homo sapiens Catalysis of the reaction: L-alanyl-L-glutamate + H2O <=> L-alanine + L-glutamate http://amigo.geneontology.org/amigo/search/ontology?q=GO:0103046 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000260 BCR signaling pathway 63 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=bcr_5pathway&pathway_me=BCR sigling pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3518.80651374693 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX031542 GO:0103053 molecular_function 1-ethyladenine demethylase activity 2 Homo sapiens Catalysis of the reaction: 1-ethyladenine + O2 + 2-oxoglutarate(2-) <=> adenine + carbon dioxide + acetaldehyde + succinate http://amigo.geneontology.org/amigo/search/ontology?q=GO:0103053 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX031543 GO:0103066 molecular_function 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity 1 Homo sapiens Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H http://amigo.geneontology.org/amigo/search/ontology?q=GO:0103066 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031544 GO:0103067 molecular_function 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity 1 Homo sapiens Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H http://amigo.geneontology.org/amigo/search/ontology?q=GO:0103067 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031545 GO:0103068 molecular_function leukotriene C4 gamma-glutamyl transferase activity 5 Homo sapiens Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid http://amigo.geneontology.org/amigo/search/ontology?q=GO:0103068 PAGER curation team PAGER-contact@googlegroups.com 53.7883959044369 2 13-AUG-20 GOA A 21894
TAX031546 GO:0103073 molecular_function anandamide amidohydrolase activity 2 Homo sapiens Catalysis of the reaction: anandamide + H2O <=> arachidonate + ethanolaminium(1+) http://amigo.geneontology.org/amigo/search/ontology?q=GO:0103073 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000252 RXR and RAR hetrodimerization with other nuclear receptor 14 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 708.550514013438 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX031548 GO:0104004 biological_process cellular response to environmental stimulus 278 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0104004 PAGER curation team PAGER-contact@googlegroups.com 482.612772713483 2 13-AUG-20 GOA A 21894
TAX031549 GO:0104005 molecular_function hijacked molecular function 76 Homo sapiens A function that was not selected for in the evolution of an organism, but arises from co-option by another organism, e.g. a human protein used as a virus receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0104005 PAGER curation team PAGER-contact@googlegroups.com 252.199124067795 2 13-AUG-20 GOA A 21894
TAX031550 GO:0106001 biological_process intestinal hexose absorption 6 Homo sapiens Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106001 PAGER curation team PAGER-contact@googlegroups.com 135.910779100194 2 13-AUG-20 GOA A 21894
TAX031551 GO:0106003 cellular_component amyloid-beta complex 1 Homo sapiens Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106003 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031552 GO:0106004 biological_process tRNA (guanine-N7)-methylation 2 Homo sapiens The process whereby a guanine in a tRNA is methylated at the N7 position of guanine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106004 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX031553 GO:0106005 biological_process RNA 5'-cap (guanine-N7)-methylation 1 Homo sapiens The process whereby a guanine in 5-cap is methylated at the N7 position of guanine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106005 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000620 DNA replication 33 Homo sapiens A complex network of interacting proteins and enzymes is required for D replication. Generally, D replication follows a multistep enzymatic pathway. At the D replication fork, a D helicase (DB or MCM complex) precedes the D synthetic machinery and unwinds the duplex parental D in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, D replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a D polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The D primase (DG) is needed to form R primers. Normally, during replication of the lagging-strand D template, an R primer is removed either by an Rse H or by the 5 to 3 exonuclease activity of D pol I, and the D ligase joins the Okazaki fragments. In eukaryotes, three D polymerases (alpha, delta, and epsilon) have been identified. D primase forms a permanent complex with D polymerase alpha. PC and RFC function as a clamp and a clamp loader. FEN 1 and Rse H1 remove the R from the Okazaki fragments and D ligase I joins the D. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03030 PAGER curation team PAGER-contact@googlegroups.com 9777.4798273082 1.0 13-AUG-20 KEGG P 199
WAG000621 Pentose and glucuronate interconversions 39 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00040 PAGER curation team PAGER-contact@googlegroups.com 497.943209726812 1.0 13-AUG-20 KEGG P 199
WAG000622 Biotin metabolism 4 Homo sapiens Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00780 PAGER curation team PAGER-contact@googlegroups.com 79.8458149779736 1.0 13-AUG-20 KEGG P 199
WAG000623 Lipoic acid metabolism 4 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00785 PAGER curation team PAGER-contact@googlegroups.com 129.88986784141 1.0 13-AUG-20 KEGG P 199
WAG000624 Glycine, serine and threonine metabolism 35 Homo sapiens Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00260 PAGER curation team PAGER-contact@googlegroups.com 982.538164546442 1.0 13-AUG-20 KEGG P 199
WAG000806 VEGF signaling pathway 60 Homo sapiens There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial sigl transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different sigling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kise-MEK-mitogen-activated protein kise (MAPK) pathway and subsequent initiation of D synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kise (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration sigling. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04370 PAGER curation team PAGER-contact@googlegroups.com 3264.94569262144 1.0 13-AUG-20 KEGG P 199
WAG000807 Valine, leucine and isoleucine degradation 42 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00280 PAGER curation team PAGER-contact@googlegroups.com 1840.54897386947 1.0 13-AUG-20 KEGG P 199
WAG000808 RNA polymerase 21 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03020 PAGER curation team PAGER-contact@googlegroups.com 6883.42494026376 1.0 13-AUG-20 KEGG P 199
WAG000809 Huntington's disease 27 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05040 PAGER curation team PAGER-contact@googlegroups.com 767.536336685217 1.0 13-AUG-20 KEGG P 199
WAG000810 Drug metabolism - cytochrome P450 69 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00982 PAGER curation team PAGER-contact@googlegroups.com 8561.06444179967 1.0 13-AUG-20 KEGG P 199
WAG000811 Fc epsilon RI signaling pathway 65 Homo sapiens Fc epsilon RI-mediated sigling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous sigling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04664 PAGER curation team PAGER-contact@googlegroups.com 4976.32531845134 1.0 13-AUG-20 KEGG P 199
WAG000812 1- and 2-Methylnaphthalene degradation 10 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00624 PAGER curation team PAGER-contact@googlegroups.com 43.5124309652611 1.0 13-AUG-20 KEGG P 199
WAG000814 Methionine metabolism 22 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00271 PAGER curation team PAGER-contact@googlegroups.com 964.792546456089 1.0 13-AUG-20 KEGG P 199
WAG000815 ABC transporters 38 Homo sapiens The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD). http://www.genome.jp/dbget-bin/www_bget?pathway+hsa02010 PAGER curation team PAGER-contact@googlegroups.com 606.276776607718 1.0 13-AUG-20 KEGG P 199
WAG000816 Atrazine degradation 8 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00791 PAGER curation team PAGER-contact@googlegroups.com 184.389420757852 1.0 13-AUG-20 KEGG P 199
WAG000817 Pantothenate and CoA biosynthesis 26 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00770 PAGER curation team PAGER-contact@googlegroups.com 419.955552728162 1.0 13-AUG-20 KEGG P 199
TAX031389 GO:0099534 molecular_function calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration 2 Homo sapiens The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099534 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX031391 GO:0099537 biological_process trans-synaptic signaling 307 Homo sapiens Cell-cell signaling in either direction across the synaptic cleft. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099537 PAGER curation team PAGER-contact@googlegroups.com 376.691236788062 2 13-AUG-20 GOA A 21894
TAX031393 GO:0099540 biological_process trans-synaptic signaling by neuropeptide 1 Homo sapiens Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099540 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031394 GO:0099541 biological_process trans-synaptic signaling by lipid 3 Homo sapiens Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099541 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031395 GO:0099542 biological_process trans-synaptic signaling by endocannabinoid 3 Homo sapiens Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099542 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031396 GO:0099543 biological_process trans-synaptic signaling by soluble gas 2 Homo sapiens Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099543 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031397 GO:0099545 biological_process trans-synaptic signaling by trans-synaptic complex 7 Homo sapiens Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099545 PAGER curation team PAGER-contact@googlegroups.com 29.3647058823529 2 13-AUG-20 GOA A 21894
TAX031398 GO:0099546 biological_process protein catabolic process, modulating synaptic transmission 1 Homo sapiens Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099546 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031400 GO:0099548 biological_process trans-synaptic signaling by nitric oxide 2 Homo sapiens Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099548 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031401 GO:0099550 biological_process trans-synaptic signaling, modulating synaptic transmission 10 Homo sapiens Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099550 PAGER curation team PAGER-contact@googlegroups.com 24.8555377207063 2 13-AUG-20 GOA A 21894
TAX031402 GO:0099551 biological_process trans-synaptic signaling by neuropeptide, modulating synaptic transmission 1 Homo sapiens Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099551 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031403 GO:0099552 biological_process trans-synaptic signaling by lipid, modulating synaptic transmission 2 Homo sapiens Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099552 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031404 GO:0099553 biological_process trans-synaptic signaling by endocannabinoid, modulating synaptic transmission 2 Homo sapiens Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099553 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031405 GO:0099554 biological_process trans-synaptic signaling by soluble gas, modulating synaptic transmission 1 Homo sapiens Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099554 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031406 GO:0099555 biological_process trans-synaptic signaling by nitric oxide, modulating synaptic transmission 1 Homo sapiens Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099555 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031407 GO:0099557 biological_process trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission 3 Homo sapiens Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099557 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX031408 GO:0099558 biological_process maintenance of synapse structure 12 Homo sapiens A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099558 PAGER curation team PAGER-contact@googlegroups.com 119.339628173289 2 13-AUG-20 GOA A 21894
TAX031409 GO:0099560 biological_process synaptic membrane adhesion 23 Homo sapiens The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099560 PAGER curation team PAGER-contact@googlegroups.com 20.1114112086428 2 13-AUG-20 GOA A 21894
TAX031410 GO:0099562 biological_process maintenance of postsynaptic density structure 4 Homo sapiens A process which maintains the organization and the arrangement of proteins in the presynaptic density. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099562 PAGER curation team PAGER-contact@googlegroups.com 226.45236784141 2 13-AUG-20 GOA A 21894
TAX031554 GO:0106014 biological_process regulation of inflammatory response to wounding 2 Homo sapiens Any process that modulates the frequency, rate or extent of the inflammatory response to wounding. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106014 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031555 GO:0106015 biological_process negative regulation of inflammatory response to wounding 2 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106015 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031556 GO:0106017 molecular_function phosphatidylinositol-3,4-bisphosphate phosphatase activity 4 Homo sapiens Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106017 PAGER curation team PAGER-contact@googlegroups.com 79.8458149779736 2 13-AUG-20 GOA A 21894
TAX031557 GO:0106018 molecular_function phosphatidylinositol-3,5-bisphosphate phosphatase activity 15 Homo sapiens Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106018 PAGER curation team PAGER-contact@googlegroups.com 1304.97173143763 2 13-AUG-20 GOA A 21894
TAX031558 GO:0106019 molecular_function phosphatidylinositol-4,5-bisphosphate phosphatase activity 12 Homo sapiens Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106019 PAGER curation team PAGER-contact@googlegroups.com 386.798674346946 2 13-AUG-20 GOA A 21894
TAX031559 GO:0106020 biological_process regulation of vesicle docking 3 Homo sapiens Any process that modulates the frequency, rate or extent of vesicle docking. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106020 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031560 GO:0106022 biological_process positive regulation of vesicle docking 1 Homo sapiens Any process that activates or increases the frequency, rate or extent of vesicle docking. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106022 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000606 Apoptosis 78 Homo sapiens Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a sigling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04210 PAGER curation team PAGER-contact@googlegroups.com 4139.33489511953 1.0 13-AUG-20 KEGG P 199
WAG000607 gamma-Hexachlorocyclohexane degradation 21 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00361 PAGER curation team PAGER-contact@googlegroups.com 532.007952219349 1.0 13-AUG-20 KEGG P 199
WAG000608 Linoleic acid metabolism 37 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00591 PAGER curation team PAGER-contact@googlegroups.com 16582.1710896417 1.0 13-AUG-20 KEGG P 199
WAG000609 Axon guidance 109 Homo sapiens Axon guidance represents a key stage in the formation of neurol network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and sigl transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04360 PAGER curation team PAGER-contact@googlegroups.com 1173.20033231201 1.0 13-AUG-20 KEGG P 199
WAG000610 Chronic myeloid leukemia 67 Homo sapiens Chronic myelogenous leukemia (CML) origites in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and other hematopoetic cell lineages are involved in the process of clol proliferation and differentiation. On the cellular level, CML is associated with a specific chromosome abnormality, the t(9; 22) reciprocal translocation that forms the Philadelphia (Ph) chromosome. The Ph chromosome is the result of a molecular rearrangement between the c-ABL proto-oncogene on chromosome 9 and the BCR (breakpoint cluster region) gene on chromosome 22. The BCR/ABL fusion gene encodes p210 BCR/ABL, an oncoprotein, which, unlike the normal p145 c-Abl, has constitutive tyrosine kise activity and is predomintly localized in the cytoplasm. While fusion of c-ABL and BCR is believed to be the primary cause of the chronic phase of CML, progression to blast crisis requires other molecular changes. Common secondary abnormalities include mutations in TP53, RB, and p16/INK4A, or overexpression of genes such as EVI1. Additiol chromosome translocations are also observed,such as t(3;21)(q26;q22), which generates AML1-EVI1. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05220 PAGER curation team PAGER-contact@googlegroups.com 3807.03487877684 1.0 13-AUG-20 KEGG P 199
TAX031587 GO:0106101 biological_process ER-dependent peroxisome localization 1 Homo sapiens A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106101 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031588 GO:0106104 biological_process regulation of glutamate receptor clustering 3 Homo sapiens Any process that modulates the frequency, rate or extent of glutamate receptor clustering. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106104 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031589 GO:0106105 molecular_function Ala-tRNA(Thr) hydrolase activity 1 Homo sapiens Catalysis of the hydrolysis of misacylated ala-tRNA(thr). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106105 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031590 GO:0106118 biological_process regulation of sterol biosynthetic process 42 Homo sapiens Any process that modulates the frequency, rate or extent of a sterol biosynthetic process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106118 PAGER curation team PAGER-contact@googlegroups.com 1934.1365477836 2 13-AUG-20 GOA A 21894
TAX031592 GO:0106120 biological_process positive regulation of sterol biosynthetic process 5 Homo sapiens Any process that activates or increases the frequency, rate or extent of a sterol biosynthetic process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106120 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031593 GO:0106130 molecular_function purine phosphoribosyltransferase activity 3 Homo sapiens Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106130 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX031594 GO:0106134 biological_process positive regulation of cardiac muscle cell contraction 3 Homo sapiens Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106134 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031595 GO:0106135 biological_process negative regulation of cardiac muscle cell contraction 2 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106135 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031596 GO:0110008 biological_process ncRNA deadenylation 1 Homo sapiens Shortening of the poly(A) tail of a nuclear-transcribed ncRNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0110008 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031561 GO:0106027 biological_process neuron projection organization 39 Homo sapiens A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106027 PAGER curation team PAGER-contact@googlegroups.com 227.287569435776 2 13-AUG-20 GOA A 21894
TAX031562 GO:0106028 biological_process neuron projection retraction 2 Homo sapiens The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106028 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000805 Selenoamino acid metabolism 30 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00450 PAGER curation team PAGER-contact@googlegroups.com 298.983622078981 1.0 13-AUG-20 KEGG P 199
WIG001539 HCV Life Cycle 2 Homo sapiens HCV Life Cycle http://www.proteinlounge.com/pathway/HCV Life Cycle PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001554 IL-1 Pathway 42 Homo sapiens IL-1 Pathway http://www.proteinlounge.com/pathway/IL-1 Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 331.415160900329 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001575 Intrinsic Prothrombin Activation Pathway 24 Homo sapiens Intrinsic Prothrombin Activation Pathway http://www.proteinlounge.com/pathway/Intrinsic Prothrombin Activation Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 644.611795159686 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001629 PKA Signaling 172 Homo sapiens PKA Signaling http://www.proteinlounge.com/pathway/PKA Signaling PAGER curation team PAGER-contact@googlegroups.com CURRENT 201.82756263126 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001654 Antiproliferative Role of SSTR2 43 Homo sapiens Antiproliferative Role of SSTR2 http://www.proteinlounge.com/pathway/Antiproliferative Role of SSTR2 PAGER curation team PAGER-contact@googlegroups.com CURRENT 250.645039595607 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001685 Apoptotic Pathways in Synovial Fibroblasts 115 Homo sapiens Apoptotic Pathways in Synovial Fibroblasts http://www.proteinlounge.com/pathway/Apoptotic Pathways in Synovial Fibroblasts PAGER curation team PAGER-contact@googlegroups.com CURRENT 251.273117015875 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001712 Transendothelial Migration of Leukocytes 252 Homo sapiens Transendothelial Migration of Leukocytes http://www.proteinlounge.com/pathway/Transendothelial Migration of Leukocytes PAGER curation team PAGER-contact@googlegroups.com CURRENT 283.141124342521 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001740 MIF Action Through Endocytic Pathway 11 Homo sapiens MIF Action Through Endocytic Pathway http://www.proteinlounge.com/pathway/MIF Action Through Endocytic Pathway PAGER curation team PAGER-contact@googlegroups.com CURRENT 102.590035156897 N 1.0 13-AUG-20 Protein Lounge P 388
WIG001920 TWEAK Signaling Pathway 42 Homo sapiens TWEAK Signaling Pathway http://www.wikipathways.org/index.php/Pathway:WP2036 PAGER curation team PAGER-contact@googlegroups.com Khanspers CURRENT 3511.16546824583 N 1.0 13-AUG-20 WikiPathway P 144
WIG001980 Non-homologous end joining 5 Homo sapiens Non-homologous end joining http://www.wikipathways.org/index.php/Pathway:WP438 PAGER curation team PAGER-contact@googlegroups.com Thomas, AlexanderPico, Khanspers, MaintBot, MartijnVanIersel, Chetan1 CURRENT 1152.95503784362 N 1.0 13-AUG-20 WikiPathway P 144
WIG002010 Heme Biosynthesis 9 Homo sapiens Heme Biosynthesis http://www.wikipathways.org/index.php/Pathway:WP561 PAGER curation team PAGER-contact@googlegroups.com Kdahlquist, MaintBot, Khanspers, Mills42, Andra, AlexanderPico CURRENT 1951.46439011656 N 1.0 13-AUG-20 WikiPathway P 144
TAX031563 GO:0106029 molecular_function tRNA pseudouridine synthase activity 3 Homo sapiens Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106029 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031564 GO:0106030 biological_process neuron projection fasciculation 21 Homo sapiens The collection of neuronal projections into a bundle of rods, known as a fascicle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106030 PAGER curation team PAGER-contact@googlegroups.com 60.4910938819429 2 13-AUG-20 GOA A 21894
TAX031565 GO:0106044 biological_process guanine deglycation 1 Homo sapiens The removal of a sugar or dicarbonyl from a glycated guanine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106044 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031566 GO:0106045 biological_process guanine deglycation, methylglyoxal removal 1 Homo sapiens The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106045 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031568 GO:0106049 biological_process regulation of cellular response to osmotic stress 6 Homo sapiens Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106049 PAGER curation team PAGER-contact@googlegroups.com 17.1866295264624 2 13-AUG-20 GOA A 21894
TAX031569 GO:0106050 molecular_function tRNA 2'-O-methyltransferase activity 2 Homo sapiens Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106050 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031570 GO:0106056 biological_process regulation of calcineurin-mediated signaling 32 Homo sapiens Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106056 PAGER curation team PAGER-contact@googlegroups.com 59.4164993750903 2 13-AUG-20 GOA A 21894
GEX000836 hip geometry 6 Homo sapiens hip geometry associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000492 copd 4 Homo sapiens copd associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 GAD G 1671
WIG001514 G1-S Phase Transition 40 Homo sapiens G1-S Phase Transition http://www.proteinlounge.com/pathway/G1-S Phase Transition PAGER curation team PAGER-contact@googlegroups.com CURRENT 1324.14637455095 N 1.0 13-AUG-20 Protein Lounge P 388
GEX000595 dna adducts 2 Homo sapiens dna adducts associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001619 upper aerodigestive tract cancer 5 Homo sapiens upper aerodigestive tract cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 340.449448889386 N 1.0 13-AUG-20 GAD G 1671
GEX000191 atopy (total & specific ige) 1 Homo sapiens atopy (total & specific ige) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000702 follicular lymphoma 2 Homo sapiens follicular lymphoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 GAD G 1671
TAX031572 GO:0106058 biological_process positive regulation of calcineurin-mediated signaling 16 Homo sapiens Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106058 PAGER curation team PAGER-contact@googlegroups.com 12.1658986175115 2 13-AUG-20 GOA A 21894
TAX031573 GO:0106064 biological_process regulation of cobalamin metabolic process 1 Homo sapiens Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106064 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031574 GO:0106068 cellular_component SUMO ligase complex 7 Homo sapiens A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106068 PAGER curation team PAGER-contact@googlegroups.com 856.482660669902 2 13-AUG-20 GOA A 21894
TAX031575 GO:0106070 biological_process regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway 12 Homo sapiens Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein coupled receptor signaling pathway http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106070 PAGER curation team PAGER-contact@googlegroups.com 135.298070732156 2 13-AUG-20 GOA A 21894
TAX031576 GO:0106071 biological_process positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway 5 Homo sapiens Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein coupled receptor signaling pathway. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106071 PAGER curation team PAGER-contact@googlegroups.com 87.4402730375427 2 13-AUG-20 GOA A 21894
TAX031577 GO:0106072 biological_process negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway 9 Homo sapiens Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein coupled receptor signaling pathway. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106072 PAGER curation team PAGER-contact@googlegroups.com 180.986767737217 2 13-AUG-20 GOA A 21894
TAX031579 GO:0106074 biological_process aminoacyl-tRNA metabolism involved in translational fidelity 8 Homo sapiens Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106074 PAGER curation team PAGER-contact@googlegroups.com 348.417235935662 2 13-AUG-20 GOA A 21894
TAX031580 GO:0106075 molecular_function peptide N-succinyltransferase activity 1 Homo sapiens Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106075 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031581 GO:0106077 biological_process histone succinylation 4 Homo sapiens The modification of a histone by the addition of an succinyl group. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106077 PAGER curation team PAGER-contact@googlegroups.com 226.45236784141 2 13-AUG-20 GOA A 21894
TAX031582 GO:0106078 molecular_function histone succinyltransferase activity 1 Homo sapiens Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106078 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031583 GO:0106083 cellular_component nuclear membrane protein complex 7 Homo sapiens Any protein complex that is part of the nuclear membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106083 PAGER curation team PAGER-contact@googlegroups.com 225.71889404009 2 13-AUG-20 GOA A 21894
TAX031584 GO:0106088 biological_process regulation of cell adhesion involved in sprouting angiogenesis 1 Homo sapiens Any process that modulates the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106088 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031585 GO:0106089 biological_process negative regulation of cell adhesion involved in sprouting angiogenesis 1 Homo sapiens Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0106089 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031384 GO:0099526 biological_process presynapse to nucleus signaling pathway 2 Homo sapiens A series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099526 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
WAG000612 Melanogenesis 88 Homo sapiens Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosise (TYR), tyrosise-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles med melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04916 PAGER curation team PAGER-contact@googlegroups.com 3100.87063489287 1.0 13-AUG-20 KEGG P 199
WAG000613 Adipocytokine signaling pathway 67 Homo sapiens Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04920 PAGER curation team PAGER-contact@googlegroups.com 1831.53656425452 1.0 13-AUG-20 KEGG P 199
WAG000614 Folate biosynthesis 52 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00790 PAGER curation team PAGER-contact@googlegroups.com 1843.40136799783 1.0 13-AUG-20 KEGG P 199
WAG000615 Heparan sulfate biosynthesis 20 Homo sapiens Heparan sulfate (HS) and heparin (Hep) are glycosaminoglycans with repeating disaccharide units that consist of alterting residues of alpha-D-glucosamine (GlcN) and uronic acid, the latter being either beta-D-glucuronic acid (GlcA) or alpha-L-iduronic acid (IdoA). In these sugar residues, sulfation modification may be performed at various positions. Structural studies show that Hep possesses a higher degree of sulfation than HS. The biosynthesis of HS/Hep occurs with the addition of the first Glcc residue by EXTL3 glycosyltransferase after completion of tetrasaccharide linkage region attached to serine residue of a core protein. The chain polymeraization is then catalyzed by EXT1 and EXT2 transferases. As the chain polymerizes, HS/Hep undergoes a series of modification reactions including N-deacetylation, N-sulfation, epimerization, and subsequently O-sulfation. As fil products of biosynthesis, HS is present in the form of hepran sulfate proteoglycan (HSPG) whereas Hep exists as a sugar chain without a core protein. The proteoglycan families with HS, as well as CS (chondroitin sulfate), DS (dermatan sulfate), and KS (keratan sulfate), are composed of two main types depending on the subcellular locations: cell membrane and extracellular matrix [BR: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00534 PAGER curation team PAGER-contact@googlegroups.com 1122.29876982944 1.0 13-AUG-20 KEGG P 199
WAG000616 Notch signaling pathway 38 Homo sapiens The Notch sigling pathway is an evolutiorily conserved, intercellular sigling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additiol proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the D binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptiol activation of Notch target genes. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04330 PAGER curation team PAGER-contact@googlegroups.com 2008.85935463389 1.0 13-AUG-20 KEGG P 199
WAG000617 Fatty acid biosynthesis 14 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00061 PAGER curation team PAGER-contact@googlegroups.com 774.224208923747 1.0 13-AUG-20 KEGG P 199
WAG000618 SNARE interactions in vesicular transport 37 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04130 PAGER curation team PAGER-contact@googlegroups.com 6699.30304512657 1.0 13-AUG-20 KEGG P 199
WAG000619 Glycerolipid metabolism 38 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00561 PAGER curation team PAGER-contact@googlegroups.com 1751.74060034614 1.0 13-AUG-20 KEGG P 199
TAX031385 GO:0099527 biological_process postsynapse to nucleus signaling pathway 8 Homo sapiens A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099527 PAGER curation team PAGER-contact@googlegroups.com 97.766541161968 2 13-AUG-20 GOA A 21894
TAX031386 GO:0099528 molecular_function G-protein coupled neurotransmitter receptor activity 40 Homo sapiens Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099528 PAGER curation team PAGER-contact@googlegroups.com 997.695838447489 2 13-AUG-20 GOA A 21894
TAX031387 GO:0099529 molecular_function neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 22 Homo sapiens Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel.) http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099529 PAGER curation team PAGER-contact@googlegroups.com 2393.99901209686 2 13-AUG-20 GOA A 21894
TAX031388 GO:0099530 molecular_function G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential 3 Homo sapiens G-protein coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099530 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX031486 GO:0102200 molecular_function N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity 1 Homo sapiens Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102200 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031487 GO:0102250 molecular_function linear malto-oligosaccharide phosphorylase activity 3 Homo sapiens Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102250 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX031488 GO:0102279 molecular_function lecithin:11-cis retinol acyltransferase activity 1 Homo sapiens Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102279 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031489 GO:0102294 molecular_function cholesterol dehydrogenase activity 2 Homo sapiens Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102294 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031490 GO:0102336 molecular_function 3-oxo-arachidoyl-CoA synthase activity 7 Homo sapiens Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102336 PAGER curation team PAGER-contact@googlegroups.com 185.042537578412 2 13-AUG-20 GOA A 21894
TAX031491 GO:0102337 molecular_function 3-oxo-cerotoyl-CoA synthase activity 7 Homo sapiens Catalysis of the reaction: tetracosanoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxohexacosanoyl-CoA + carbon dioxide + coenzyme A. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102337 PAGER curation team PAGER-contact@googlegroups.com 185.042537578412 2 13-AUG-20 GOA A 21894
TAX031492 GO:0102338 molecular_function 3-oxo-lignoceronyl-CoA synthase activity 7 Homo sapiens Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102338 PAGER curation team PAGER-contact@googlegroups.com 185.042537578412 2 13-AUG-20 GOA A 21894
TAX031493 GO:0102339 molecular_function 3-oxo-arachidoyl-CoA reductase activity 1 Homo sapiens Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA(4-) + NADP(3-) <=> 3-oxoicosanoyl-CoA + NADPH + H+. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102339 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031494 GO:0102340 molecular_function 3-oxo-behenoyl-CoA reductase activity 1 Homo sapiens Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA(4-) + NADP(3-) <=> 3-oxodocosanoyl-CoA + NADPH + H+. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102340 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031495 GO:0102341 molecular_function 3-oxo-lignoceroyl-CoA reductase activity 1 Homo sapiens Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA + NADP <=> 3-oxotetracosanoyl-CoA + NADPH + H+. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102341 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031496 GO:0102342 molecular_function 3-oxo-cerotoyl-CoA reductase activity 1 Homo sapiens Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA + NADP <=> 3-oxohexacosanoyl-CoA + NADPH + H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102342 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031497 GO:0102343 molecular_function 3-hydroxy-arachidoyl-CoA dehydratase activity 4 Homo sapiens Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA <=> trans-2-icosenoyl-CoA + H2O http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102343 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031498 GO:0102344 molecular_function 3-hydroxy-behenoyl-CoA dehydratase activity 4 Homo sapiens Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA <=> trans-2-docosenoyl-CoA + H2O. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102344 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031500 GO:0102389 molecular_function polyprenol reductase activity 1 Homo sapiens Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102389 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031501 GO:0102390 molecular_function mycophenolic acid acyl-glucuronide esterase activity 1 Homo sapiens Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O <=> mycophenolate + H+ + D-glucopyranuronate http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102390 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031502 GO:0102391 molecular_function decanoate-CoA ligase activity 8 Homo sapiens Catalysis of the reaction: decanoate + ATP(4-) + coenzyme A(4-) <=> decanoyl-CoA(4-) + AMP(2-) + diphosphoric acid http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102391 PAGER curation team PAGER-contact@googlegroups.com 342.673752545825 2 13-AUG-20 GOA A 21894
TAX031503 GO:0102420 molecular_function sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity 4 Homo sapiens Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102420 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031504 GO:0102483 molecular_function scopolin beta-glucosidase activity 1 Homo sapiens Catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102483 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031505 GO:0102485 molecular_function dATP phosphohydrolase activity 3 Homo sapiens Catalysis of the reaction: dATP + 2 H2O = dAMP + 2 hydrogenphosphate + 2 H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102485 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX031506 GO:0102486 molecular_function dCTP phosphohydrolase activity 3 Homo sapiens Catalysis of the reaction: dCTP + 2 H2O = dCMP + 2 hydrogenphosphate + 2 H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102486 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX031508 GO:0102488 molecular_function dTTP phosphohydrolase activity 3 Homo sapiens Catalysis of the reaction: dTTP + 2 H2O = dTMP + 2 hydrogenphosphate + 2 H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102488 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX031509 GO:0102489 molecular_function GTP phosphohydrolase activity 3 Homo sapiens Catalysis of the reaction: GTP + 2 H2O = GMP + 2 hydrogenphosphate + 2 H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102489 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX031510 GO:0102490 molecular_function 8-oxo-dGTP phosphohydrolase activity 3 Homo sapiens Catalysis of the reaction: 8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 hydrogenphosphate + 2 H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102490 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX031511 GO:0102491 molecular_function dGTP phosphohydrolase activity 3 Homo sapiens Catalysis of the reaction: dGTP + 2 H2O = dGMP + 2 hydrogenphosphate + 2 H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102491 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX031512 GO:0102499 molecular_function SHG alpha-glucan phosphorylase activity 3 Homo sapiens Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102499 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX031513 GO:0102500 molecular_function beta-maltose 4-alpha-glucanotransferase activity 1 Homo sapiens Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102500 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031514 GO:0102521 molecular_function tRNA-4-demethylwyosine synthase activity 2 Homo sapiens Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102521 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031515 GO:0102522 molecular_function tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity 1 Homo sapiens Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe <=> 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102522 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031516 GO:0102524 molecular_function tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity 1 Homo sapiens Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102524 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031517 GO:0102549 molecular_function 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity 1 Homo sapiens Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O <=> sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102549 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031518 GO:0102555 molecular_function octanoyl transferase activity (acting on glycine-cleavage complex H protein) 1 Homo sapiens Catalysis of the reaction: [glycine cleavage system lipoyl-carrier protein]-L-lysine + OCTANOYL-ACP = H+ + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein] http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102555 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031519 GO:0102567 molecular_function phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) 19 Homo sapiens Catalysis of the reaction: 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102567 PAGER curation team PAGER-contact@googlegroups.com 1359.37607478891 2 13-AUG-20 GOA A 21894
TAX031520 GO:0102568 molecular_function phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) 19 Homo sapiens Catalysis of the reaction: 1-18:1-2-18:1-phosphatidylethanolamine + H2O = 1-oleoyl-sn-glycero-3-phosphoethanolamine + oleate + H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102568 PAGER curation team PAGER-contact@googlegroups.com 1359.37607478891 2 13-AUG-20 GOA A 21894
TAX031522 GO:0102704 molecular_function GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity 1 Homo sapiens Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102704 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031523 GO:0102707 molecular_function S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity 1 Homo sapiens Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102707 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG001241 yaci and bcma stimulation of b cell immune responses 8 Homo sapiens TACI and BCMA sigl transduction pathway that enhances cell survival APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors. Both APRIL and BAFF bind to both the BCMA and TACI receptors to activate the humoral immune response, stimulating B cell immunoglobulin production and proliferation. BAFF is found as a membrane bound form in T cells and a soluble form that is released from the cell to stimulate B cell proliferation and differentiation. As members of the TNF receptor gene family, BCMA and TACI interact with TRAF family members to transduce sigls downstream to NF-kappaB activation and MAP kise pathways. Abnormally active BAFF or APRIL sigling may play a role in autoimmune disorders such as lupus. https://cgap.nci.nih.gov/Pathways/BioCarta/h_tall1Pathway PAGER curation team PAGER-contact@googlegroups.com 1266.11801908029 1.0 13-AUG-20 BioCarta P 252
TAX021084 GO:0031629 biological_process synaptic vesicle fusion to presynaptic active zone membrane 13 Homo sapiens Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031629 PAGER curation team PAGER-contact@googlegroups.com 600.870671157812 2 13-AUG-20 GOA A 21894
WAG000611 Aminophosphonate metabolism 36 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00440 PAGER curation team PAGER-contact@googlegroups.com 723.133423015776 1.0 13-AUG-20 KEGG P 199
WIG001940 Notch Signaling Pathway 46 Homo sapiens Notch Signaling Pathway http://www.wikipathways.org/index.php/Pathway:WP268 PAGER curation team PAGER-contact@googlegroups.com 127.0.0.1, MaintBot, AlexanderPico, Thomas, Khanspers, Nsalomonis CURRENT 1878.91425383595 N 1.0 13-AUG-20 WikiPathway P 144
WAG001029 actions of nitric oxide in the heart 23 Homo sapiens Nitric oxide (NO) has a number of important physiological actions in the cardiovascular system. In the heart, NO plays role in keeping the vessels patent via vasodilation and prevention of platelet aggregation. It also plays an important role in regulating the force and rate of contraction. In vivo NO is released by shear stress of ligands that increase intracellular Ca2+ in endothelial cells. The increase intracellular Ca2+ activates nitric oxide synthase III (NOSIII) by promoting the binding of Ca/Calmodulin to the enzyme. NOSIII, which is resident in the Golgi complex, is transported together with caveolin-1 to the caveolae at the plasma membrane via vesicles. Shear stress sigls via a potassium channel and the cytoskeleton, which results in tyrosine phosphorylation of specific proteins, activation of phosphatidylinositol 3-kise, and subsequently in activation of Akt kise. Akt activation by shear stress but also by VEGF activates NOSIII by serine phosphorylation, which increases the affinity of NOSIII for calmodulin. After agonist binding at the plasma membrane, NOSIII-activating receptors translocate to caveolae. VEGF receptor sigls via its tyrosine kise domain. Furthermore, agonist receptors activate calcium channels of the endoplasmic reticulum (ER) via phospholipase C and inositol 1,4,5-trisphosphate. This calcium flux induces binding of calmodulin to NOSIII, whereas the NOSIII-caveolin-1 interaction is disrupted. At the same time, NOSIII is translocated into the cytosol. On binding of calmodulin, NOSIII generates NO, is enhanced by the interaction with Hsp90. Once activated, NOSIII catabolizes L-arginine to NO, which diffuses out of the cell. NO stimulates guanylate (G-) cyclase and increases cGMP levels. cGMP activates cGMP-dependent protein kise (PKG), cGMP-inhibited phosphodiesterase (PDEIII), and cGMP-stimulated phosphodiesterase (PDEII). PKG may reduce the force and rate of contraction, possibly by phosphorylating troponin I or by phosphorylating phospholamban. PDEIII is inhibited by the increases in cGMP brought about by NO. This may result in an increase in cAMP and cAMP-dependent protein kise (PKA). PKA in turn activates Ca2+ channels, countering the effects of PKG. In contrast, cGMP may stimulate PDEII, reduce cAMP levels and PKA activity, and thereby reduce Ca2+ channel activity. Ach, acetylcholine. CAT-1, cationic amino acid transporter. https://cgap.nci.nih.gov/Pathways/BioCarta/h_no1Pathway PAGER curation team PAGER-contact@googlegroups.com 980.146288149753 1.0 13-AUG-20 BioCarta P 252
WAG001030 the information processing pathway at the ifn beta enhancer 21 Homo sapiens The packaging of eukaryotic D into nucleosomes inhibits the access of factors to D and results in the repression of transcription, replication and recombition. Local modification of histones on enhancers and promoters is required to activate gene expression. The transcription factors that bind to nucleosome-free regions of D or to D within nucleosomes recruit two types of enzymatic activities that modify the surrounding chromatin architecture. Chromatin remodeling machines, such as SWI/SNF complex, alter the structure of the pronucleosome in an ATP-dependent manner, and often cause nucleosome sliding. The second type of chromatin modifying complexes recruited by transcription factors covalently modify the N-termil tails of histones by adding or removing phosphate, methyl, or acetyl groups. https://cgap.nci.nih.gov/Pathways/BioCarta/h_pcafpathway PAGER curation team PAGER-contact@googlegroups.com 4907.53010134258 1.0 13-AUG-20 BioCarta P 252
WAG001031 hiv-1 defeats host-mediated resistance by cem15 4 Homo sapiens Cells have many defenses against viral infection, including intracellular proteins that interfere with viral replication. Just as mammals have evolved defenses against viruses, viruses have evolved countermeasures to defeat cellular defenses. Vif is a viral gene produced by the HIV virus whose molecular function has remained unclear, but many aspects of its behavior have been revealed. Vif proteins are required for the production of infectious viral particles in many cells, acting to repress an intracellular T cell antiviral defense. Vif interacts with viral R and may help package viral genomic R to form mature virus. Some Vif is also found packaged in virion particles and multimerization of Vif appears to play a role in its activity. https://cgap.nci.nih.gov/Pathways/BioCarta/h_vifPathway PAGER curation team PAGER-contact@googlegroups.com 129.88986784141 1.0 13-AUG-20 BioCarta P 252
WAG001032 rb tumor suppressor/checkpoint signaling in response to dna damage 12 Homo sapiens Cell cycle checkpoint controls at the G1 to S transition and the G2 to M transition prevent the cell cycle from progressing when D is damaged. The ATM protein kise detects D damage and in response to this activates D repair factors and inhibits cell cycle progression. Two of the proteins that ATM phosphorylates in response to D damage are the tumor suppressor p53 and the checkpoint kise chk1. In turn, the tumor suppressor p53 interacts with p21 to block the activity of cdk2 (cyclin dependent kise 2) preventing passage from G1 to S phase and harmful replication of damaged D. One of the targets of cdk2 is the Rb gene product, another tumor suppressor. When dephosphorylated, Rb interacts with E2F transcription factors and prevents transcription of genes required for progression through the cell cycle. When phosphorylated by cell cycle dependent kises like cdk2 and cdk4, Rb no longer interacts with E2F and the cell cycle proceeds through the G1-S checkpoint (see 'Cyclins and Cell Cycle Regulation' pathway and 'Cell Cycle: G1/S Check Point' pathway). D damage also regulates the G2-M phase transition by acting on the cell cycle regulator cdc2 (See 'cdc25 and chk1 Regulatory Pathway in response to D damage'). https://cgap.nci.nih.gov/Pathways/BioCarta/h_rbPathway PAGER curation team PAGER-contact@googlegroups.com 1483.81897320248 1.0 13-AUG-20 BioCarta P 252
WAG001033 t cell receptor signaling pathway 34 Homo sapiens The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains (shown here) or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation sigl to the T cell's transcriptiol machiry upon engagement of the receptor. https://cgap.nci.nih.gov/Pathways/BioCarta/h_tcrPathway PAGER curation team PAGER-contact@googlegroups.com 4407.34977837766 1.0 13-AUG-20 BioCarta P 252
TAX021071 GO:0031594 cellular_component neuromuscular junction 71 Homo sapiens The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031594 PAGER curation team PAGER-contact@googlegroups.com 92.4504470521662 2 13-AUG-20 GOA A 21894
WAG000852 IL23-mediated signaling events 37 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=il23pathway&pathway_me=IL23-mediated sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 6289.99792099792 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000853 JNK signaling in the CD4+ TCR pathway 12 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 1504.07893556843 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000854 Syndecan-3-mediated signaling events 16 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 558.708682726623 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000855 HIV-1 Nef: Negative effector of Fas and TNF-alpha 35 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=hivnefpathway&pathway_me=HIV-1 Nef: Negative effector of Fas and TNF-alpha&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 7043.38144941903 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000856 Caspase cascade in apoptosis 45 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=caspase_pathway&pathway_me=Caspase Cascade in Apoptosis&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3080.06184247978 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000857 Retinoic acid receptors-mediated signaling 22 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 2006.24840940423 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000859 Osteopontin-mediated events 27 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 2207.21474704484 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000860 amb2 Integrin signaling 33 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 1734.12050740776 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000861 Sumoylation by RanBP2 regulates transcriptional repression 11 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 3001.35242116374 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000862 Aurora C signaling 3 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=aurora_c_pathway&pathway_me=Aurora%20C%20sigling&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX021072 GO:0031595 cellular_component nuclear proteasome complex 8 Homo sapiens A proteasome found in the nucleus of a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031595 PAGER curation team PAGER-contact@googlegroups.com 1963.88898193804 2 13-AUG-20 GOA A 21894
TAX021073 GO:0031597 cellular_component cytosolic proteasome complex 12 Homo sapiens A proteasome complex found in the cytosol of a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031597 PAGER curation team PAGER-contact@googlegroups.com 4432.41311396247 2 13-AUG-20 GOA A 21894
TAX021074 GO:0031616 cellular_component spindle pole centrosome 14 Homo sapiens A centrosome from which one pole of a mitotic or meiotic spindle is organized. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031616 PAGER curation team PAGER-contact@googlegroups.com 40.0551124812734 2 13-AUG-20 GOA A 21894
TAX021077 GO:0031622 biological_process positive regulation of fever generation 7 Homo sapiens Any process that activates or increases the frequency, rate, or extent of fever generation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031622 PAGER curation team PAGER-contact@googlegroups.com 147.829257900343 2 13-AUG-20 GOA A 21894
TAX021078 GO:0031623 biological_process receptor internalization 56 Homo sapiens A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031623 PAGER curation team PAGER-contact@googlegroups.com 265.473506240897 2 13-AUG-20 GOA A 21894
TAX021079 GO:0031624 molecular_function ubiquitin conjugating enzyme binding 33 Homo sapiens Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031624 PAGER curation team PAGER-contact@googlegroups.com 2.27012758468984 2 13-AUG-20 GOA A 21894
TAX021080 GO:0031625 molecular_function ubiquitin protein ligase binding 309 Homo sapiens Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031625 PAGER curation team PAGER-contact@googlegroups.com 700.502429286812 2 13-AUG-20 GOA A 21894
TAX021081 GO:0031626 molecular_function beta-endorphin binding 1 Homo sapiens Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031626 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX021082 GO:0031627 biological_process telomeric loop formation 3 Homo sapiens The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031627 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX021083 GO:0031628 molecular_function opioid receptor binding 9 Homo sapiens Interacting selectively and non-covalently with an opioid receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031628 PAGER curation team PAGER-contact@googlegroups.com 78.5975352971164 2 13-AUG-20 GOA A 21894
TAX021085 GO:0031630 biological_process regulation of synaptic vesicle fusion to presynaptic active zone membrane 11 Homo sapiens Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031630 PAGER curation team PAGER-contact@googlegroups.com 248.071362599664 2 13-AUG-20 GOA A 21894
TAX021086 GO:0031632 biological_process positive regulation of synaptic vesicle fusion to presynaptic active zone membrane 4 Homo sapiens Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031632 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX021087 GO:0031635 biological_process adenylate cyclase-inhibiting opioid receptor signaling pathway 2 Homo sapiens The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031635 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX021088 GO:0031638 biological_process zymogen activation 35 Homo sapiens The proteolytic processing of an inactive enzyme to an active form. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031638 PAGER curation team PAGER-contact@googlegroups.com 86.2330713153418 2 13-AUG-20 GOA A 21894
TAX031411 GO:0099563 biological_process modification of synaptic structure 11 Homo sapiens Any process that modifies the structure/morphology of a synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099563 PAGER curation team PAGER-contact@googlegroups.com 265.883550411852 2 13-AUG-20 GOA A 21894
TAX031412 GO:0099564 biological_process modification of synaptic structure, modulating synaptic transmission 1 Homo sapiens Any process that modulates synaptic transmission via modification of the structure of the synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099564 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031413 GO:0099566 biological_process regulation of postsynaptic cytosolic calcium ion concentration 9 Homo sapiens Any process that regulates the concentration of calcium in the postsynaptic cytosol. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099566 PAGER curation team PAGER-contact@googlegroups.com 43.689407540395 2 13-AUG-20 GOA A 21894
WAG000259 Angiopoietin receptor Tie2-mediated signaling 43 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=angiopoietinreceptor_pathway&pathway_me=Angiopoietin receptor Tie2-mediated sigling&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2991.553850852 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX031414 GO:0099567 molecular_function calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration 1 Homo sapiens The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099567 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031415 GO:0099568 cellular_component cytoplasmic region 218 Homo sapiens Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099568 PAGER curation team PAGER-contact@googlegroups.com 79.6847768924662 2 13-AUG-20 GOA A 21894
TAX031416 GO:0099569 cellular_component presynaptic cytoskeleton 3 Homo sapiens The portion of the cytoskeleton contained within the presynapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099569 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX031419 GO:0099575 biological_process regulation of protein catabolic process at presynapse, modulating synaptic transmission 3 Homo sapiens Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099575 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031420 GO:0099576 biological_process regulation of protein catabolic process at postsynapse, modulating synaptic transmission 4 Homo sapiens Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099576 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031421 GO:0099577 biological_process regulation of translation at presynapse, modulating synaptic transmission 1 Homo sapiens Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099577 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031422 GO:0099578 biological_process regulation of translation at postsynapse, modulating synaptic transmission 3 Homo sapiens Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099578 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX031423 GO:0099579 molecular_function G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2 Homo sapiens G-protein coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099579 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031424 GO:0099580 molecular_function ion antiporter activity involved in regulation of postsynaptic membrane potential 2 Homo sapiens Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099580 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX031425 GO:0099582 molecular_function neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration 1 Homo sapiens Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099582 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031426 GO:0099583 molecular_function neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration 3 Homo sapiens Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099583 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX031427 GO:0099587 biological_process inorganic ion import across plasma membrane 49 Homo sapiens The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099587 PAGER curation team PAGER-contact@googlegroups.com 34.4230142541624 2 13-AUG-20 GOA A 21894
TAX031428 GO:0099588 biological_process positive regulation of postsynaptic cytosolic calcium concentration 1 Homo sapiens Any process that increases the concentration of calcium ions in the postsynaptic cytosol. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099588 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031429 GO:0099589 molecular_function serotonin receptor activity 24 Homo sapiens Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099589 PAGER curation team PAGER-contact@googlegroups.com 1669.74027912447 2 13-AUG-20 GOA A 21894
WAG000254 HIF-1-alpha transcription factor network 60 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=hif1apathway&pathway_me=Hypoxic%20and%20oxygen%20homeostasis%20regulation%20of%20HIF-1-alpha&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1278.79618156864 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000255 TCR signaling in naive CD8+ T cells 48 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 3965.26163027856 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000256 Noncanonical Wnt signaling pathway 11 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 454.858276995953 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000257 IFN-gamma pathway 30 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=ifngpathway&pathway_me=IFN-gamma pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1997.92458678389 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000258 FAS signaling pathway (CD95) 34 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=faspathway&pathway_me=FAS (CD95) sigling pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2324.17387773995 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX031430 GO:0099590 biological_process neurotransmitter receptor internalization 6 Homo sapiens A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099590 PAGER curation team PAGER-contact@googlegroups.com 17.1866295264624 2 13-AUG-20 GOA A 21894
TAX031431 GO:0099601 biological_process regulation of neurotransmitter receptor activity 52 Homo sapiens Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099601 PAGER curation team PAGER-contact@googlegroups.com 194.623395490341 2 13-AUG-20 GOA A 21894
TAX031432 GO:0099602 molecular_function neurotransmitter receptor regulator activity 11 Homo sapiens A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099602 PAGER curation team PAGER-contact@googlegroups.com 68.6367406178727 2 13-AUG-20 GOA A 21894
TAX031433 GO:0099604 molecular_function ligand-gated calcium channel activity 24 Homo sapiens Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099604 PAGER curation team PAGER-contact@googlegroups.com 463.916989872872 2 13-AUG-20 GOA A 21894
TAX031434 GO:0099606 biological_process microtubule plus-end directed mitotic chromosome migration 1 Homo sapiens The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099606 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031435 GO:0099607 biological_process lateral attachment of mitotic spindle microtubules to kinetochore 1 Homo sapiens The cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099607 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031436 GO:0099609 molecular_function microtubule lateral binding 2 Homo sapiens Interacting selectively and non-covalently with the side of a microtubule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099609 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031437 GO:0099612 biological_process protein localization to axon 8 Homo sapiens A process in which a protein is transported to or maintained in a location within an axon. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099612 PAGER curation team PAGER-contact@googlegroups.com 144.898585727302 2 13-AUG-20 GOA A 21894
TAX031439 GO:0099622 biological_process cardiac muscle cell membrane repolarization 16 Homo sapiens The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099622 PAGER curation team PAGER-contact@googlegroups.com 510.179036348178 2 13-AUG-20 GOA A 21894
TAX031440 GO:0099623 biological_process regulation of cardiac muscle cell membrane repolarization 24 Homo sapiens Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099623 PAGER curation team PAGER-contact@googlegroups.com 664.590874811463 2 13-AUG-20 GOA A 21894
TAX031441 GO:0099624 biological_process atrial cardiac muscle cell membrane repolarization 5 Homo sapiens The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099624 PAGER curation team PAGER-contact@googlegroups.com 188.558607956135 2 13-AUG-20 GOA A 21894
TAX031442 GO:0099625 biological_process ventricular cardiac muscle cell membrane repolarization 8 Homo sapiens The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099625 PAGER curation team PAGER-contact@googlegroups.com 535.471429815629 2 13-AUG-20 GOA A 21894
TAX031443 GO:0099627 biological_process neurotransmitter receptor cycle 1 Homo sapiens The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome. This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent anchoring (trapping). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099627 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031444 GO:0099628 biological_process neurotransmitter receptor diffusion trapping 2 Homo sapiens The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099628 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031445 GO:0099629 cellular_component postsynaptic specialization of symmetric synapse 2 Homo sapiens A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099629 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031446 GO:0099630 biological_process postsynaptic neurotransmitter receptor cycle 1 Homo sapiens The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099630 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031447 GO:0099632 biological_process protein transport within plasma membrane 11 Homo sapiens A process in which protein is transported from one region of the plasma membrane to another. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099632 PAGER curation team PAGER-contact@googlegroups.com 29.9709724238026 2 13-AUG-20 GOA A 21894
TAX031448 GO:0099633 biological_process protein localization to postsynaptic specialization membrane 7 Homo sapiens A process in which a protein is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. post synaptic density). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099633 PAGER curation team PAGER-contact@googlegroups.com 409.384471535093 2 13-AUG-20 GOA A 21894
TAX031449 GO:0099634 cellular_component postsynaptic specialization membrane 5 Homo sapiens The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099634 PAGER curation team PAGER-contact@googlegroups.com 87.4402730375427 2 13-AUG-20 GOA A 21894
TAX031450 GO:0099637 biological_process neurotransmitter receptor transport 11 Homo sapiens The directed movement of neurotransmitter receptors. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099637 PAGER curation team PAGER-contact@googlegroups.com 29.9709724238026 2 13-AUG-20 GOA A 21894
TAX031451 GO:0099638 biological_process endosome to plasma membrane protein transport 8 Homo sapiens The directed movement of proteins from the endosome to the plasma membrane in transport vesicles. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099638 PAGER curation team PAGER-contact@googlegroups.com 30.3680430879713 2 13-AUG-20 GOA A 21894
TAX031452 GO:0099639 biological_process neurotransmitter receptor transport, endosome to plasma membrane 8 Homo sapiens The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099639 PAGER curation team PAGER-contact@googlegroups.com 37.7902240325866 2 13-AUG-20 GOA A 21894
WAG000261 Signaling events mediated by VEGFR1 and VEGFR2 61 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 4766.7974304343 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000262 Cellular roles of Anthrax toxin 13 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=anthraxpathway&pathway_me=Cellular roles of Anthrax toxin&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 806.065843022042 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX031453 GO:0099640 biological_process axo-dendritic protein transport 12 Homo sapiens The directed movement of proteins along microtubules in neuron projections. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099640 PAGER curation team PAGER-contact@googlegroups.com 45.1732604396615 2 13-AUG-20 GOA A 21894
TAX031454 GO:0099641 biological_process anterograde axonal protein transport 9 Homo sapiens The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099641 PAGER curation team PAGER-contact@googlegroups.com 64.3066914910123 2 13-AUG-20 GOA A 21894
TAX031455 GO:0099642 biological_process retrograde axonal protein transport 2 Homo sapiens The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099642 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX031456 GO:0099643 biological_process signal release from synapse 86 Homo sapiens Any signal release from a synapse. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099643 PAGER curation team PAGER-contact@googlegroups.com 227.286672656586 2 13-AUG-20 GOA A 21894
TAX031457 GO:0099645 biological_process neurotransmitter receptor localization to postsynaptic specialization membrane 7 Homo sapiens A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099645 PAGER curation team PAGER-contact@googlegroups.com 409.384471535093 2 13-AUG-20 GOA A 21894
TAX031459 GO:0099738 cellular_component cell cortex region 28 Homo sapiens The complete extent of cell cortex that underlies some some region of the plasma membrane http://amigo.geneontology.org/amigo/search/ontology?q=GO:0099738 PAGER curation team PAGER-contact@googlegroups.com 59.2494846832488 2 13-AUG-20 GOA A 21894
TAX031460 GO:0100002 biological_process negative regulation of protein kinase activity by protein phosphorylation 1 Homo sapiens Any protein phosphorylation process that negatively_regulates protein kinase activity http://amigo.geneontology.org/amigo/search/ontology?q=GO:0100002 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031461 GO:0100012 biological_process regulation of heart induction by canonical Wnt signaling pathway 1 Homo sapiens Any canonical Wnt signaling pathway process that regulates heart induction http://amigo.geneontology.org/amigo/search/ontology?q=GO:0100012 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG000264 Alternative NF-kappaB pathway 6 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=nfkappabaltertivepathway&pathway_me=Altertive NF-kappaB pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1152.95503784362 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000266 IL1-mediated signaling events 31 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=il1pathway&pathway_me=IL1-mediated sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3957.07771833034 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000267 Ephrin B reverse signaling 17 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=ephrinb_ephbpathway&pathway_me=EphrinB-EPHB pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 791.542190429891 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000268 Proteogylcan syndecan-mediated signaling events 4 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=syndecan_pathway&pathway_me=Proteoglycan syndecan-mediated sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX031462 GO:0100057 biological_process regulation of phenotypic switching by transcription from RNA polymerase II promoter 1 Homo sapiens Any transcription from RNA polymerase II promoter process that regulates phenotypic switching http://amigo.geneontology.org/amigo/search/ontology?q=GO:0100057 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031463 GO:0101003 cellular_component ficolin-1-rich granule membrane 60 Homo sapiens The lipid bilayer surrounding a ficolin-1-rich granule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0101003 PAGER curation team PAGER-contact@googlegroups.com 77.130195690184 2 13-AUG-20 GOA A 21894
TAX031464 GO:0101005 molecular_function ubiquitinyl hydrolase activity 123 Homo sapiens Catalysis of the hydrolysis of ubiquitin from proteins and other molecules. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0101005 PAGER curation team PAGER-contact@googlegroups.com 154.823292546759 2 13-AUG-20 GOA A 21894
TAX031465 GO:0101006 molecular_function protein histidine phosphatase activity 3 Homo sapiens Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate http://amigo.geneontology.org/amigo/search/ontology?q=GO:0101006 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031466 GO:0101020 molecular_function estrogen 16-alpha-hydroxylase activity 5 Homo sapiens Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0101020 PAGER curation team PAGER-contact@googlegroups.com 882.508700274157 2 13-AUG-20 GOA A 21894
TAX031467 GO:0101030 biological_process tRNA-guanine transglycosylation 2 Homo sapiens The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0101030 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031468 GO:0101031 cellular_component chaperone complex 21 Homo sapiens A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0101031 PAGER curation team PAGER-contact@googlegroups.com 1939.29399339924 2 13-AUG-20 GOA A 21894
TAX031469 GO:0102007 molecular_function acyl-L-homoserine-lactone lactonohydrolase activity 3 Homo sapiens Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102007 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX031470 GO:0102008 molecular_function cytosolic dipeptidase activity 1 Homo sapiens Catalysis of the reaction: H2O + a dipeptide <=> 2 a standard alpha amino acid that occurs in the cytosol http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102008 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031471 GO:0102009 molecular_function proline dipeptidase activity 1 Homo sapiens Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102009 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031472 GO:0102076 molecular_function beta,beta-carotene-9',10'-cleaving oxygenase activity 1 Homo sapiens Catalysis of the reaction: beta-carotene + O2 <=> 10'-apo-beta-carotenal + beta-ionone http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102076 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031473 GO:0102077 molecular_function oleamide hydrolase activity 2 Homo sapiens Catalysis of the reaction: oleamide + H2O <=> oleate + ammonium http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102077 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031474 GO:0102084 molecular_function L-dopa O-methyltransferase activity 2 Homo sapiens Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine <=> 3-O-methyldopa + S-adenosyl-L-homocysteine + H+ http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102084 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031475 GO:0102092 molecular_function 5-diphosphoinositol pentakisphosphate 3-kinase activity 2 Homo sapiens Catalysis of the reaction: 5-diphospho-1D-myo-inositol pentakisphosphate + ATP = 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102092 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX031476 GO:0102102 molecular_function homocarnosine synthase activity 1 Homo sapiens Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102102 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031477 GO:0102113 molecular_function hypoxia-inducible factor-asparagine oxygenase activity 1 Homo sapiens Catalysis of the reaction: 2-oxoglutarate + O2 + a hypoxia inducible factor (HIF) alpha subunit = succinate + carbon dioxide + a (3S)-3-hydroxy-L-asparagine-HIF alpha subunit http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102113 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031478 GO:0102116 molecular_function laurate hydroxylase activity 1 Homo sapiens Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ <=> 11-hydroxylaurate + NADP + H2O http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102116 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031479 GO:0102121 molecular_function ceramidase activity 4 Homo sapiens Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102121 PAGER curation team PAGER-contact@googlegroups.com 282.003028634361 2 13-AUG-20 GOA A 21894
TAX031481 GO:0102132 molecular_function 3-oxo-pimeloyl-[acp] methyl ester reductase activity 1 Homo sapiens Catalysis of the reaction: NADP + a 3R-hydroxypimeloyl-[acp] methyl ester <=> NADPH + H+ + a 3-oxo-pimeloyl-[acp] methyl ester. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102132 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX031482 GO:0102148 molecular_function N-acetyl-beta-D-galactosaminidase activity 2 Homo sapiens Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan http://amigo.geneontology.org/amigo/search/ontology?q=GO:0102148 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX021089 GO:0031639 biological_process plasminogen activation 10 Homo sapiens The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031639 PAGER curation team PAGER-contact@googlegroups.com 392.484685126195 2 13-AUG-20 GOA A 21894
TAX021090 GO:0031640 biological_process killing of cells of other organism 48 Homo sapiens Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031640 PAGER curation team PAGER-contact@googlegroups.com 116.56865126905 2 13-AUG-20 GOA A 21894
TAX021091 GO:0031641 biological_process regulation of myelination 35 Homo sapiens Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031641 PAGER curation team PAGER-contact@googlegroups.com 35.4341048742397 2 13-AUG-20 GOA A 21894
TAX021092 GO:0031642 biological_process negative regulation of myelination 6 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031642 PAGER curation team PAGER-contact@googlegroups.com 38.857938718663 2 13-AUG-20 GOA A 21894
TAX021093 GO:0031643 biological_process positive regulation of myelination 15 Homo sapiens Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031643 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX021094 GO:0031644 biological_process regulation of neurological system process 121 Homo sapiens Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031644 PAGER curation team PAGER-contact@googlegroups.com 229.679393882347 2 13-AUG-20 GOA A 21894
TAX021095 GO:0031645 biological_process negative regulation of neurological system process 21 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031645 PAGER curation team PAGER-contact@googlegroups.com 15.2720848056537 2 13-AUG-20 GOA A 21894
TAX021096 GO:0031646 biological_process positive regulation of neurological system process 57 Homo sapiens Any process that activates or increases the frequency, rate or extent of a neurophysiological process. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031646 PAGER curation team PAGER-contact@googlegroups.com 86.7820614013293 2 13-AUG-20 GOA A 21894
TAX021097 GO:0031647 biological_process regulation of protein stability 251 Homo sapiens Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031647 PAGER curation team PAGER-contact@googlegroups.com 242.73266078973 2 13-AUG-20 GOA A 21894
TAX021098 GO:0031648 biological_process protein destabilization 41 Homo sapiens Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031648 PAGER curation team PAGER-contact@googlegroups.com 92.09974672677 2 13-AUG-20 GOA A 21894
TAX021099 GO:0031649 biological_process heat generation 8 Homo sapiens Any homeostatic process in which an organism produces heat, thereby raising its internal temperature. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031649 PAGER curation team PAGER-contact@googlegroups.com 320.443609979633 2 13-AUG-20 GOA A 21894
TAX021100 GO:0031650 biological_process regulation of heat generation 13 Homo sapiens Any process that modulates the rate or extent of heat generation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031650 PAGER curation team PAGER-contact@googlegroups.com 102.757290767023 2 13-AUG-20 GOA A 21894
TAX021101 GO:0031651 biological_process negative regulation of heat generation 1 Homo sapiens Any process that stops, prevents, or reduces the rate or extent of heat generation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031651 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX021102 GO:0031652 biological_process positive regulation of heat generation 11 Homo sapiens Any process that activates or increases the rate or extent of heat generation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031652 PAGER curation team PAGER-contact@googlegroups.com 114.572879950238 2 13-AUG-20 GOA A 21894
TAX021104 GO:0031658 biological_process negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle 7 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031658 PAGER curation team PAGER-contact@googlegroups.com 1381.79805894189 2 13-AUG-20 GOA A 21894
TAX021105 GO:0031659 biological_process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle 7 Homo sapiens Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031659 PAGER curation team PAGER-contact@googlegroups.com 48.1647058823529 2 13-AUG-20 GOA A 21894
TAX021106 GO:0031663 biological_process lipopolysaccharide-mediated signaling pathway 31 Homo sapiens A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031663 PAGER curation team PAGER-contact@googlegroups.com 1686.81685325486 2 13-AUG-20 GOA A 21894
TAX021108 GO:0031665 biological_process negative regulation of lipopolysaccharide-mediated signaling pathway 13 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031665 PAGER curation team PAGER-contact@googlegroups.com 3.47746650426309 2 13-AUG-20 GOA A 21894
WAG000642 cadmium induces dna synthesis and proliferation in macrophages 14 Homo sapiens Exposure to divalent cadmium ions (Cd2+) is a known cancer risk factor, but the molecular mechanisms responsible for the ippropriate induction of cellular proliferation by cadmium are still being figured out. One cellular model used to study this process is macrophages grown in culture. In cultured macrophages, cadmium acts both at the cell surface and in the cytoplasm to induce proliferation. At the cell surface, cadmium interacts with a pertussis-sensitive cell surface receptor, probably a Gi-coupled GPCR, to stimulate proliferation. Cadmium can enter cells through calcium ion channels and once in cells affects calcium release by the ER. In addition to changes in intracellular calcium, the proliferative effects of cadmium are mediated by the Ras/Map kise pathway, and also NF-kB. Inhibition of phospholipase C, map kises, or NF-kB with a variety of pharmacological inhibitors all blocked the activation of cellular proliferation by cadmium. Protein kise C is also activated by cadmium, upstream of the Map kise pathway. Changes in transcription induced by cadmium include induction of immediate early genes like fos, jun, and myc. In addition to inducing cellular proliferation, cadmium also is slightly genotoxic due to inhibition of D repair, activates stress genes, and inhibits the immune system. The immuno-modulatory effects observed with cadmium treatment may also involvement transcriptiol disregulation, including the expression of cytokines such as IL-4, IL-10, and TNF-alpha. Although macrophages have been used for many studies, other cell types are also the target of cadmium?toxicity. https://cgap.nci.nih.gov/Pathways/BioCarta/h_cdMacPathway PAGER curation team PAGER-contact@googlegroups.com 2007.97964838017 1.0 13-AUG-20 BioCarta P 252
WAG000643 e2f1 destruction pathway 10 Homo sapiens E2F-1 is a transcription factor that regulates the expression of genes involved in the cell cycle and that is involved in progression of the cell cycle from G1 into S phase. Over-expression of E2F-1 can induce cellular transformation and its under-expression can repress apoptosis. Association with the tumor suppressor Rb represses E2F-1 activity, and this repression is relieved when the cdk2/cyclin E complex at the G1 to S phase transition phosphorylates Rb. Like many cell cycle regulators, E2F-1 is regulated through phosphorylation by a cyclin-dependent protein kise, cdk2/cyclin A, and by proteolytic degradation. Phosphorylation of E2F-1 by cdk2/cyclin A leads to E2F-1 ictivation, blocking D binding. E2F-1 is also regulated through degradation in the proteosome at the S/G2 transition. The F box complex that degrades E2F-1 contains components shared with the complexes that target other cell cycle factors for degradation. The F box protein that specifically recruits E2F for ubiquitition and degradation is Skp2. Other components of the SCF complex include Skp1, Cul1, and cdc34. Skp2 expression is cyclical, increasing in the S/G2 transition as E2F-1 is degraded. Knowledge of E2F-1 activity and its regulation form part of the complex set of interactions regulating the cell cycle and potential targets for the treatment of cancer. https://cgap.nci.nih.gov/Pathways/BioCarta/h_skp2e2fPathway PAGER curation team PAGER-contact@googlegroups.com 3219.27998432192 1.0 13-AUG-20 BioCarta P 252
WAG001254 control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) 12 Homo sapiens The differentiation of muscle cells is transcriptiolly regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to MyoD and other basic helix-loop-helix factors to activate transcription of genes involved in muscle cell differentiation. Transcriptiol activation by MEF2 is blocked by interaction with HDAC5 and other histone deacetylases. In undifferentiated myoblasts, HDAC5 is present in the nucleus where it binds to MEF2 to block activation of muscle genes. When activated by IGF-1 sigling, CaM kise phosphorylates HDAC proteins, causing them to be exported from the nucleus, releasing the block on MEF2 transcriptiol activation and allowing differentiation to proceed. Transcription cofactors also interact with MEF2 to contribute to gene regulation and myogenesis. The transcriptiol regulator NFAT, for example, acts as a cofactor for MEF2 when calcium and calcineurin sigling activate it. https://cgap.nci.nih.gov/Pathways/BioCarta/h_hdacPathway PAGER curation team PAGER-contact@googlegroups.com 419.401761454137 1.0 13-AUG-20 BioCarta P 252
WAG000599 Glycolysis / Gluconeogenesis 79 Homo sapiens Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and DH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00010 PAGER curation team PAGER-contact@googlegroups.com 2384.40476814445 1.0 13-AUG-20 KEGG P 199
WAG000600 Ribosome 66 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03010 PAGER curation team PAGER-contact@googlegroups.com 44742.2528921373 1.0 13-AUG-20 KEGG P 199
WAG001255 rac1 cell motility signaling pathway 18 Homo sapiens Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellular sigls. Several changes in cytoskeletal structure and other aspects of cell structure are involved in cell motility. Rac-1 is activated by GEF factors, and repressed by GAPs. GEFs are guanine nucleotide exchange factors, including Trio and Vav. Sos-1 is involved in Ras sigling and also acts as a GEF for Rac to transduce sigls between Ras and Rac. SWAP-70 is a Rac GEF that binds IP3 and transduces sigls from tyrosine kises to Rac to modulate the cytoskeleton and cause membrane ruffling. GAPs are GTPase- activating proteins. Rac stimulates the formation of actin-based structures such as filopodia and lamellopodia, while GAPs such as chimerin oppose the formation of these Rac dependent structures. Several different factors downstream of Rac act on cytoskeletal structure and other aspects of cell motility. Pak1 provides a direct link from Rac to cell motility through phosphorylation of the myosin light chain. Pak1 also phosphorylates and activates LIM kise, which phosphorylates cofilin as one target. Cofilin stimulates actin depolymerization and changes in cell structure, and phosphorylation of cofilin by LIM kise represses its activity. In neurons, Rac acts through the protein kise cdk5 and p35 to phosphorylate and downregulate Pak1, increasing neurol migration. Rac-1 also interacts with several other factors to regulate a variety of processes. Interaction of Por1 with Rac-1 is involved in membrane ruffling. WAVE is a member of the WASP family of proteins that regulate actin organization and that is involved in Rac sigling to cause membrane ruffling. Interaction of Rac-1 with MEKK1 integrates Rac sigling with pathways sigling through map kises. https://cgap.nci.nih.gov/Pathways/BioCarta/h_rac1Pathway PAGER curation team PAGER-contact@googlegroups.com 486.675506077837 1.0 13-AUG-20 BioCarta P 252
WAG001256 phosphatidylcholine biosynthesis pathway 3 Homo sapiens The main components of biological membranes are phosphoglyceride lipids composed of a glycerol unit esterified to two fatty acids and a polar alcohol group. The properties of phospholipids give lipid bilayer membranes their self-organizing structure. The polar alcohol group is hydrophilic and organizes itself in the membrane facing outward toward water, while the hydrophobic fatty acid alkyl chains face inward toward other fatty acid chains. One of the primary membrane phospholipids is phosphatidylcholine, in which the polar head group is composed of phosphocholine. The biosynthesis of phosphatidylcholine and phosphatidylethanolamine follow similar routes. The first step in phosphatidylcholine is the phosphorylation of choline to make phosphocholine, which is then activated by CTP. CDP-choline reacts with diacylglycerol to produce phosphatidylcholine. https://cgap.nci.nih.gov/Pathways/BioCarta/ PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 BioCarta P 252
WAG001257 phospholipase c delta in phospholipid associated cell signaling 4 Homo sapiens Phospholipase C (PLC) d1 is a member of the PLC family that produces two second messengers, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) by hydrolyzing the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). DAG in combition with Ca++ is necessary for further activation of Protein Kise C, while IP3 diffuses into the cytoplasm and mediates the release of intracellular calcium. PLC d1 has a pleckstrin homology (PH) domain that binds to PIP2 in the membrane with an affinity of 1.7 mM. It has selectivity for PIP2 over other phosphatidylinositol lipids and provides a specific probe for activation of PIP2 metabolism to DG and IP3. Activation of PLC d1 results in its translocation from the membrane to the cytoplasm. PLC d1 activity is feedback-inhibited by IP3, which has a 8-fold higher affinity for PLC d1 than does PIP2. The members of the PLC family play a key role in the sigl transduction cascade for many receptors. At basal Ca++ levels PLC d1 has been shown to be activated by the adrenoreceptor a1B, adrenoreceptor a1D, a-thromboxane receptor and oxytocin receptor. The G protein involved is the GTP-binding protein known as tissue transglutamise (Gah or TGII). Gah is a bifunctiol enzyme, having GTPase and transglutamise (TGase) activity and is present in the plasma membrane, cytosol, and nucleus. Exchange of GDP to GTP by Gah is facilitated by activation of the receptors. However, a bimodal regulation of PLC d1 activity has been observed depending on Ca++ levels and occupancy of the guanine nucleotide bindign site of Gah. In addition, the GTPase activating protein RhoGAP interacts with and stimulates PLC d1. The complex regulation of PLC d1 activity ebles the protein to modulate intracellular sigling. https://cgap.nci.nih.gov/Pathways/BioCarta/h_plcdPathway PAGER curation team PAGER-contact@googlegroups.com 129.88986784141 1.0 13-AUG-20 BioCarta P 252
WAG001470 transcription factor creb and its extracellular signals 18 Homo sapiens The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular sigls including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kise A and the calmodulin-dependent protein kises CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptiol activity. Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133. Phosphorylation occurs at Ser133 via p44/42 MAP Kise and p90RSK and also via p38 MAP Kise and MSK1. CREB exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively. https://cgap.nci.nih.gov/Pathways/BioCarta/h_crebPathway PAGER curation team PAGER-contact@googlegroups.com 1447.0995449858 1.0 13-AUG-20 BioCarta P 252
WAG001471 signaling pathway from g-protein families 19 Homo sapiens G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation. The bg subunits from Gai and other G proteins are able to activate the MAP kise pathways and PLCb. GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC. Second messenger pathways then activate a range of effector systems to change cell behaviour; in many cases this includes the regulation of gene transcription. Dotted line shows a more indirect pathway. https://cgap.nci.nih.gov/Pathways/BioCarta/h_gpcrPathway PAGER curation team PAGER-contact@googlegroups.com 1574.58465068817 1.0 13-AUG-20 BioCarta P 252
WAG001472 cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway 12 Homo sapiens The defects in cAMP-regulated chloride channel CTFR are believed to be the major cause for cystic fibrosis. Regulation of CFTR protein by the surface receptor beta adrenergic receptor is mediated through the ezrin/radixin/moesin binding phosphoprotein 50 (EBP50), which binds both the C-termini CFTR and b2AR through their PDZ binding motifs. In the resting state, CFTR, b2AR, and EBP50 exist as a macromolecular complex on the apical surface of epithelial cells. Upon agonist activation of the b2AR, the adenulate cyclase is stimulated through the G protein pathway, leading to an increase in cAMP. The elevated concentration of cAMP activates PKA, which is anchored near CFTR via interaction with Ezrin. The phosphorylation of CFTR by PKA disrupts the complex and leads to compartmentalized and specific sigling of the channel. https://cgap.nci.nih.gov/Pathways/BioCarta/h_cftrPathway PAGER curation team PAGER-contact@googlegroups.com 4170.94574365342 1.0 13-AUG-20 BioCarta P 252
WAG001473 lck and fyn tyrosine kinases in initiation of tcr activation 10 Homo sapiens T cell activation is initiated by recognition of antigen by the T cell receptor (TCR) in the context of Class II MHC on an antigen-presenting cell. The T cell receptor contains multiple subunits and interacts with several factors to transduce antigen-stimulated T cell activation. One of the key steps that initiates receptor activation is the tyrosine phosphorylation of TCR subunits by the src family protein kises Lck and Fyn. T cell receptor phosphorylated by Lck and Fyn recruits the ZAP-70 protein kise to the receptor complex, which becomes activated and stimulates downstream pathways like the Map kise cascade (see 'T Cell Receptor Sigling Pathway'). The CD45 protein tyrosine phosphatase activates Lck and Fyn by dephosphorylating these proteins and is required for TCR activation. Association of the CD4 coreceptor with Lck may also be involved in Lck activation. https://cgap.nci.nih.gov/Pathways/BioCarta/h_tcraPathway PAGER curation team PAGER-contact@googlegroups.com 4302.99846952107 1.0 13-AUG-20 BioCarta P 252
TAX021109 GO:0031666 biological_process positive regulation of lipopolysaccharide-mediated signaling pathway 8 Homo sapiens Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031666 PAGER curation team PAGER-contact@googlegroups.com 97.766541161968 2 13-AUG-20 GOA A 21894
TAX021110 GO:0031667 biological_process response to nutrient levels 417 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031667 PAGER curation team PAGER-contact@googlegroups.com 318.247665218093 2 13-AUG-20 GOA A 21894
TAX021111 GO:0031668 biological_process cellular response to extracellular stimulus 225 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031668 PAGER curation team PAGER-contact@googlegroups.com 172.382532705281 2 13-AUG-20 GOA A 21894
TAX021112 GO:0031669 biological_process cellular response to nutrient levels 201 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031669 PAGER curation team PAGER-contact@googlegroups.com 171.659823613947 2 13-AUG-20 GOA A 21894
TAX021113 GO:0031670 biological_process cellular response to nutrient 56 Homo sapiens Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031670 PAGER curation team PAGER-contact@googlegroups.com 104.021810136343 2 13-AUG-20 GOA A 21894
TAX021114 GO:0031672 cellular_component A band 14 Homo sapiens The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031672 PAGER curation team PAGER-contact@googlegroups.com 678.970544887671 2 13-AUG-20 GOA A 21894
TAX021115 GO:0031673 cellular_component H zone 1 Homo sapiens A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031673 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX021116 GO:0031674 cellular_component I band 21 Homo sapiens A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031674 PAGER curation team PAGER-contact@googlegroups.com 148.86410036679 2 13-AUG-20 GOA A 21894
TAX021117 GO:0031681 molecular_function G-protein beta-subunit binding 9 Homo sapiens Interacting selectively and non-covalently with a G-protein beta subunit. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031681 PAGER curation team PAGER-contact@googlegroups.com 165.825717332466 2 13-AUG-20 GOA A 21894
TAX021118 GO:0031682 molecular_function G-protein gamma-subunit binding 1 Homo sapiens Interacting selectively and non-covalently with a G-protein gamma subunit. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031682 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX021119 GO:0031683 molecular_function G-protein beta/gamma-subunit complex binding 20 Homo sapiens Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031683 PAGER curation team PAGER-contact@googlegroups.com 5593.17057190179 2 13-AUG-20 GOA A 21894
TAX021120 GO:0031685 molecular_function adenosine receptor binding 4 Homo sapiens Interacting selectively and non-covalently with an adenosine receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031685 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX021121 GO:0031686 molecular_function A1 adenosine receptor binding 1 Homo sapiens Interacting selectively and non-covalently with an A1 adenosine receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031686 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX021122 GO:0031687 molecular_function A2A adenosine receptor binding 1 Homo sapiens Interacting selectively and non-covalently with an A2A adenosine receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031687 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX021123 GO:0031690 molecular_function adrenergic receptor binding 19 Homo sapiens Interacting selectively and non-covalently with an adrenergic receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031690 PAGER curation team PAGER-contact@googlegroups.com 243.126839441117 2 13-AUG-20 GOA A 21894
TAX021124 GO:0031691 molecular_function alpha-1A adrenergic receptor binding 2 Homo sapiens Interacting selectively and non-covalently with an alpha-1A adrenergic receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031691 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX021125 GO:0031692 molecular_function alpha-1B adrenergic receptor binding 3 Homo sapiens Interacting selectively and non-covalently with an alpha-1B adrenergic receptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0031692 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX013411 GO:0000429 biological_process carbon catabolite regulation of transcription from RNA polymerase II promoter 4 Homo sapiens A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000429 PAGER curation team PAGER-contact@googlegroups.com 79.8458149779736 2 13-AUG-20 GOA A 21894
WAG000445 FOXA2 and FOXA3 transcription factor networks 37 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 696.662345603522 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000432 ion channels and their functional role in vascular endothelium 9 Homo sapiens Endothelial cells (EC) form a multifunctiol sigl-transducing surface that performs different tasks dependent on its localization in the vessel tree. Arterial EC provide a pathway for delivery of oxygen from blood to tissue. They modulate the tone of vascular smooth muscle cells, which in turn controls blood pressure and blood flow by adjusting the caliber of arteries and arterioles. In the microvascular bed, EC regulate the permeation of various metabolites, macromolecules and gases, as well as autocrine and paracrine factors and are involved in the regulation of cell nutrition. In all vessel types, EC are involved in blood coagulation, control of the transport between blood and tissue, movement of cells adhering to EC, wound healing, and angiogenesis. Other functions require an active response of EC to various sigls of mechanical, chemical, or neurol ture. This sigl transduction is impaired during vessel disease (arteriosclerosis) and injury, inflammation, or hemodymic disturbances (hypertension). The role of ion channels in the transduction of these sigls into cellular responses is still a matter of debate and has received substantial attention only in the last few years. Our current knowledge is limited to effects of ion channels on fast endothelial responses, these channels being mainly essential for the regulation of Ca2+ sigling. Here we illustrated the negative feedback of cyclic nucleotides (CNG)-induced membrane depolarization on Ca2+ entry. Ca2+ entry via receptor-activated cation channels (RACC) and/or store-operated or capacitative (SOC) elevates [Ca2+]i and stimulates endothelial nitric oxide synthase (eNOS). The subsequent activation of soluble guanylate cyclase (sGC) increases cGMP. cGMP and cAMP [via agonist activation of G protein-coupled receptors (GPCRs), Gs, and adenylate cyclase (AC)] activate CNG and/or nonselective cation channels (HCN) channels, which induces membrane depolarization. This depolarization exerts a negative feedback on Ca2+ entry via RACC/SOC. In addition, a feedback inhibition of Ca2+ entry channels via activation of PKG has been described. https://cgap.nci.nih.gov/Pathways/BioCarta/h_raccPathway PAGER curation team PAGER-contact@googlegroups.com 495.696091396936 1.0 13-AUG-20 BioCarta P 252
WAG000632 regulation of ck1/cdk5 by type 1 glutamate receptors 21 Homo sapiens Cdk5 is a cyclin dependent protein kise involved in dopaminergic sigling in the neostriatal region of the brain. The role of cdk5 in dopamine responses occurs through phosphorylation of DARPP-32. Caseine kise 1 (CK1) also regulates DARPP-32 phosphorylation and dopamine sigling. The phosphorylation of DARPP-32 by cdk5 reduced dopamine sigling. Depending on its phosphorylation state, DARPP-32 inhibits either protein phosphatase 1 (PP1) or PKA. The role of mGLUR1 in this process is supported by the induction of cdk5 and CK1 activity by the mGLUR1 agonist DHPG and the subsequent phosphorylation of DARPP-32 associated with DHPG treatment of nigrostriatal neurons. CK-1 and Ckd5 inhibitors block the DHPG induced DARPP-32 phosphorylation. Dopamine exerts a positive sigl that increases dopamine response by reversing phosphorylation of DARPP-32 at threonine-75. Dopamine initiates this pathway through activation of the D1 dopamine receptor, a Gs coupled GPCR, elevating cAMP and activating PKA. PKA activates protein phosphatase 2A (PP2A) which dephosphorylates DARPP-32 and increases dopamine responsiveness. This also removes the inhibition of PKA by DARPP-32, forming a positive feedback loop for further DARPP-32 ictivation by PKA. Activation of the D2 dopamine receptor has the opposite effect, shifting the DARPP-32 population toward the threonine-75 phosphorylated form. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ck1Pathway PAGER curation team PAGER-contact@googlegroups.com 1371.83311037672 1.0 13-AUG-20 BioCarta P 252
WAG000633 deregulation of cdk5 in alzheimers disease 6 Homo sapiens Cyclin-dependent kise 5 (cdk5), a multi-functiol kise, and its neuron-specific activator p35 are required for neurite outgrowth and cortical lamition. Proteolytic cleavage of p35 produces p25, which accumulates in the brains of patients with Alzheimer's disease. Conversion of p35 to p25 causes prolonged activation and mislocalization of cdk5 and the hyperphosphorylates tau, leading to the formation of paired helical filaments and promotes apoptosis. In cultured primary cortical neurons, excitotoxins, hypoxic stress and calcium influx induce the production of p25. In fresh brain lysates, addition of calcium can stimulate cleavage of p35 to p25. Specific inhibitors of calpain1, effectively inhibit the calcium-induced cleavage of p35. In vitro, calpain1 directly cleaves p35 to release a fragment with relative molecular mass 25,000. Application of the amyloid beta-peptide A beta induces the conversion of p35 to p25 in primary cortical neurons. Inhibition of cdk5 or calpain activity reduces cell death in A beta-treated cortical neurons. These observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease. GSK3B also phosphoryklates tau but does not induce hyperphosphorylation in response to calpain activating stimuli. Additiolly down-regulation or inhibition of PP2A increases the hyper-phosphorylation of tau. https://cgap.nci.nih.gov/Pathways/BioCarta/h_p35alzheimersPathway PAGER curation team PAGER-contact@googlegroups.com 600.933675192032 1.0 13-AUG-20 BioCarta P 252
WAG000634 mcalpain and friends in cell motility 28 Homo sapiens The mammalian calpain gene family curently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. ( An excellent introduction to the Calpain family can be found on a web site created by Valery Thompson https://cgap.nci.nih.gov/Pathways/BioCarta/h_ucalpainPathway PAGER curation team PAGER-contact@googlegroups.com 3776.96105195881 1.0 13-AUG-20 BioCarta P 252
WAG000635 fc epsilon receptor i signaling in mast cells 29 Homo sapiens The Fc Epsilon Receptor 1 sigling pathway in mast cells uses multiple core sigl path to achieve its necessary ends. Through the BTK protein and PKC Mast cells are able to degranulate, through the PKC and MAPK paths the cells are able to alter cytokine expression and arachidonic acid release. https://cgap.nci.nih.gov/Pathways/BioCarta/h_fcer1Pathway PAGER curation team PAGER-contact@googlegroups.com 5368.11339765557 1.0 13-AUG-20 BioCarta P 252
WAG001450 phosphoinositides and their downstream targets 17 Homo sapiens Nine currently identified phosphoinositide 3-kises (PI 3-K) constitute a subfamily of lipid kises that catalyze the addition of a phosphate molecule on the 3-position of the inositol ring of phosphoinositides. Phosphatidylinositol (PtdIns), the precursor of all phosphoinosi-tides (PI), constitutes less than 10% of the total lipid in eukaryotic cell membranes. Approximately 5% of cellular PI is phosphorylated at the 4-position (PtdIns-4-P), and another 5% is phosphorylated at both the 4- and 5-positions (PtdIns-4,5-P2 ). However, less than 0.25% of the total inositol-containing lipids are phosphorylated at the 3-position, consistent with the idea that these lipids exert specific regulatory functions inside the cell, as opposed to a structural function. Here we have chosen to highlight a group of the phosphoinositide targets of the PI3-Ks and their downstream targets. The downstream effects of these PI-3 targets are indicated in the lower band illustrating the important role the PI3Ks have in cell function and survival. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ptdinsPathway PAGER curation team PAGER-contact@googlegroups.com 767.059517680355 1.0 13-AUG-20 BioCarta P 252
WAG001451 hypoxia and p53 in the cardiovascular system 18 Homo sapiens Hypoxic stress, like D damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike D damage, hypoxia does not induce p53-dependent cell cycle arrest, suggesting that p53 activity is differentially regulated by these two stresses. Hypoxia induces p53 protein accumulation, but in contrast to D damage, hypoxia fails to induce endogenous downstream p53 effector mRs and proteins, such as p21, Bax, CIP1, WAF1 etc. Hypoxia does not inhibit the induction of p53 target genes by ionizing radiation, indicating that p53-dependent transactivation requires a D damage-inducible sigl that is lacking under hypoxic treatment alone. The phosphatidylinositol 3-OH-kise-Akt pathway inhibits p53-mediated transcription and apoptosis. Mdm2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 and serves as a good substrate for Akt. Mdm-2 targets the p53 tumor suppressor for ubiquitin-dependent degradation by the proteasome, but, in addition, the p53 transcription factor induces Mdm-2, thus, establishing a feedback loop. Hypoxia or D damage by abrogating binding of HIF-1 with VHL and p53 with Mdm-2, respectively, leads to stabilization and accumulation transcriptiolly active HIF-1 and p53. At the molecular level, D damage induces the interaction of p53 with the transcriptiol activator p300 as well as with the transcriptiol corepressor mSin3A. In contrast, hypoxia primarily induces an interaction of p53 with mSin3A, but not with p300. https://cgap.nci.nih.gov/Pathways/BioCarta/h_p53hypoxiaPathway PAGER curation team PAGER-contact@googlegroups.com 1501.07538954701 1.0 13-AUG-20 BioCarta P 252
WAG001452 sumoylation by ranbp2 regulates transcriptional repression 14 Homo sapiens Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptiol repression. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ranbp2Pathway PAGER curation team PAGER-contact@googlegroups.com 2927.86477784835 1.0 13-AUG-20 BioCarta P 252
WAG001453 agrin in postsynaptic differentiation 20 Homo sapiens The heparan sulphate proteoglycan agrin is well known as the key assembly factor of postsyptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle. Sigling through muscle-specific proteins such as muscle specific kise (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kise (PAK) that are involved in actin polymerization. Agrin also engages sigling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). https://cgap.nci.nih.gov/Pathways/BioCarta/h_agrPathway PAGER curation team PAGER-contact@googlegroups.com 2154.50587003118 1.0 13-AUG-20 BioCarta P 252
WAG001454 repression of pain sensation by the transcriptional regulator dream 14 Homo sapiens The molecular events that lead to the perception of pain are a key research field in medicine and drug discovery. The opioid receptors modulate pain sigling in response to endogenous peptide ligands and opiate drugs such as morphine. The kappa opioid receptor plays a key role in the profound algesia of opiates and is activated by the endogenous peptide ligand dynorphin, encoded by the prodynorphin gene. Production of prodynorphin is transcriptiolly regulated by a downstream regulatory element (DRE) in the prodynorphin gene. A transcription factor called DREAM (DRE antagonistic modulator) binds to the DRE and represses prodynorphin transcription when bound. DREAM binds calcium with 4 EF-hand motifs and the binding of DREAM to D is repressed in the presence of calcium. Many transcription factors are regulated by calcium indirectly through calcium sensitive kises and phosphatases, but DREAM is unique to date in being a transcription factor that directly binds calcium and is regulated by calcium binding. DREAM may also regulate other genes such as c-fos. https://cgap.nci.nih.gov/Pathways/BioCarta/h_dreampathway PAGER curation team PAGER-contact@googlegroups.com 1664.42314032886 1.0 13-AUG-20 BioCarta P 252
WAG001455 hiv-1 nef: negative effector of fas and tnf 32 Homo sapiens HIV infection leads to drastic declines in CD4 T helper cells, in part through apoptosis of uninfected cells. Apoptosis of uninfected cells may be induced through the expression of Fas ligand on the surface of HIV-infected cells, stimulating the Fas-dependent apoptotic pathway in cells that come in contact with infected cells. The NEF protein expressed by HIV may play induce the expression of Fas-ligand by infected cells. If this is the case, then a question that arises is how infected cells themselves escape Fas-mediated apoptosis. The NEF protein appears to play a role in this process as well. NEF interacts with the ASK1 kise (apoptosis sigl-regulating kise) involved in apoptotic sigling by TNF and Fas-ligand. Interaction of NEF with ASK1 prevents phosphorylation of downstream MAP kises and JNK kises involved in apoptotic sigling. https://cgap.nci.nih.gov/Pathways/BioCarta/h_HivnefPathway PAGER curation team PAGER-contact@googlegroups.com 6557.28171717482 1.0 13-AUG-20 BioCarta P 252
WAG001456 growth hormone signaling pathway 17 Homo sapiens Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone sigling can result in dwarfism and decreases in growth hormone levels with age have been suggested to play a role in the reduced function of some physiological systems. Growth hormone sigls a response in cells through the growth hormone receptor, a member of the cytokine receptor gene family. Growth hormone causes the receptor to dimerize, activating the JAK2 protein kise. The activity of JAK2 mediates many of the downstream responses to growth hormone through phosphorylation of STAT transcription factors, MAP kises, other kise cascades and molecules involved in metabolism like IRS-1. Factors like SOCS and SHP-1 appear to play a role in the down regulation of sigling by growth hormone and cytokines. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ghPathway PAGER curation team PAGER-contact@googlegroups.com 1994.734217654 1.0 13-AUG-20 BioCarta P 252
WAG000220 multi-drug resistance factors 5 Homo sapiens Cancer cells resistant to a diverse set of hydrophobic drugs are known as MDR cells (multidrug-resistant). Large membrane proteins overproduced in MDR cells, belong to a family of transport P-glycoproteins known as ATP-binding cassette transporter proteins (ABC-ATPases). These proteins were initially thought to affect the permeability of cells to drugs, but they were later found to to be pumps that remove drugs from cells at the cost of ATP hydrolysis. There are seven major families of ABC(ATP-binding cassette) proteins, two of them are shown on this pathway, MDR/TAP (Multi-Drug Resistance) and MRP (Multi-Drug Resistance Related Proteins). Members of the MDR/TAP subfamily are involved in multi-drug resistance as well as antigen presentation. Additiol factors involved in detoxification are the P450 cytochromes (CYPs), glutathione-S-transferase (GST). https://cgap.nci.nih.gov/Pathways/BioCarta/h_mrpPathway PAGER curation team PAGER-contact@googlegroups.com 663.65831141946 1.0 13-AUG-20 BioCarta P 252
WAG000028 the prc2 complex sets long-term gene silencing through modification of histone tails 10 Homo sapiens Packaging of D into chromatin allows the cell to store its genetic information efficiently and has an important role in regulating gene expression. Recent studies have revealed that chromatin structure can be altered by covalent modification of nucleosomes, in particular acetylation and methylation of the core histone tails. Histone hyperacetylation usually characterizes active chromatin, while histone deacetylation correlates with repressed transcription. The Polycomb group (PcG) proteins are constituents of evolutiory highly conserved molecular pathways regulating cell fate in several tissues through diverse mechanisms, including 1) regulation of self-renewal/proliferation, 2) regulation of senescence/immortalization, 3) interaction with the initiation transcription machinery, 4) interaction with chromatin-condensation proteins, 5) modification of histones, 6) ictivation of paterl X chromosome, and 7) regulation of cell death. The PcG proteins form multimeric protein complexes, PRC1 and PRC2 which are involved in the heritablestable repression of genes through modification of chromatin structure. https://cgap.nci.nih.gov/Pathways/BioCarta/h_prc2Pathway PAGER curation team PAGER-contact@googlegroups.com 3698.95736123036 1.0 13-AUG-20 BioCarta P 252
WAG000638 platelet amyloid precursor protein pathway 13 Homo sapiens The amyloid -beta peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP), is the major componenet of senile plaques, the hallmark of alzhemier?disease. Platelets contain both APP and Ab and probably contribute greater than 90% of circulating APP. The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation. Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules. These important molecules released from platelets are key regulators of hemostasis, the physiologic arrest of hemorrhage at site of vascular leakage. https://cgap.nci.nih.gov/Pathways/BioCarta/h_plateletAppPathway PAGER curation team PAGER-contact@googlegroups.com 1002.93097322475 1.0 13-AUG-20 BioCarta P 252
WAG000639 map kinase inactivation of smrt corepressor 14 Homo sapiens Corepressors are coregulators that interact with transcriptiol silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kise pathway is shown in this diagram. The EFG receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kise sigling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by each pathway is shown, causing SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF. https://cgap.nci.nih.gov/Pathways/BioCarta/h_egfr_smrtePathway PAGER curation team PAGER-contact@googlegroups.com 2053.98369150685 1.0 13-AUG-20 BioCarta P 252
WAG000640 role of erk5 in neuronal survival pathway 19 Homo sapiens Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF and neurotrophin-3 that stimulate the survival of the associated neuron. Local sigling by activated Trk receptors at the syptic terminus mediates some presyptic neurol responses to neurotrophins. Map kise pathways activated by Trk receptor activate Erk1 and Erk2 at the terminus stimulating axol growth, and PI3K activates AKT in the terminus as well. Activation of these kises does not propagate a sigl to the cell body though and does not induce a transcriptiol response. This local sigling at the terminus or local sigling at the cell body appears distinct from the sigling pathway that transduces the survival sigl from the target tissue. https://cgap.nci.nih.gov/Pathways/BioCarta/h_erk5Pathway PAGER curation team PAGER-contact@googlegroups.com 4060.02352668917 1.0 13-AUG-20 BioCarta P 252
WAG000641 bone remodeling 13 Homo sapiens Bone density and structure is maintained through a balance of bone resorption by osteoclasts and bone deposition by osteoblasts. The combition of simultaneous resorption and deposition creates continual remodeling of bone while excess osteoclast activity leads to an imbalance and a loss of bone density, causing osteoporosis. RANK (receptor activator of NF-kB ligand) is a receptor in the TNF receptor gene family that is involved in osteoclast differentiation. RANK-ligand, also called osteoprotegerin-ligand, binds to RANK, induces receptor dimerization, and activates downstream sigling. Osteoprotegerin is a decoy receptor for RANK-ligand that suppresses osteoclast activity and bone remodeling, helping to maintain balanced bone remodeling. RANK-ligand and osteoprotegerin are produced by osteoblasts and some factors regulate osteoclast activity indirectly through their action on the expression of these factors by osteoblasts. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ranklPathway PAGER curation team PAGER-contact@googlegroups.com 953.573415104089 1.0 13-AUG-20 BioCarta P 252
WAG001035 inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors 4 Homo sapiens Huntington's disease is a neurodegenerative condition caused by a domint mutation in a gene encoding a protein now called huntingtin. Large polyglutamine repeats in the huntingtin protein are the genetic defect responsible for this condition, caused by expansion of a three-base pair repeat in the gene. Similar expansions of polyglutamine repeats are also found in other genes involved in neurodegenerative conditions. The polyglutamine repeat makes huntingtin protein insoluble and triggers the formation of protein aggregates. There are a few hypotheses for the connection between these aggregates and the neurodegeneration observed in Huntington's disease. One hypothesis is that mutant huntingtin moves into the nucleus and interferes with transcriptiol activation involving the transcriptiol coactivator CBP (CREB binding protein) and other coactivators. CBP interacts with transcriptiol regulatory factors and with the basal transcriptiol machinery to help regulate transcription. CBP is a large protein with multiple domains and in addition to interacting with several different transcription factors also has a histone acetylase enzyme activity. Mutant huntingtin binds to CBP, drawing it into insoluble protein aggregates. Mutant huntingtin also interacts directly with the acetyltransferase domain of CBP, blocking this activity. Activation of CBP acetyltransferase activity by transcriptiol regulators results in the acetylation of histones in the promoter and enhancer regions of active genes, contributing to transcriptiol activation by making these genes more accessible in chromatin. The lack of CBP in Huntington's affected neurons may lead to transcriptiol repression of key genes that in turn leads to neurodegeneration. One potential treatment being tested is the treatment of Huntington's affected individuals with histone deacetylase inhibitors to restore normal acetylation levels and transcription. The repression of transcription may also be involved in other neurogenerative conditions caused by proteins with expansions of polyglutamine repeats. https://cgap.nci.nih.gov/Pathways/BioCarta/h_HuntingtonPathway PAGER curation team PAGER-contact@googlegroups.com 449.593691000629 1.0 13-AUG-20 BioCarta P 252
WAG001036 the igf-1 receptor and longevity 13 Homo sapiens A demonstrated means to increase lifespan in a wide range of organisms is through the restriction of caloric intake. Reducing the consumption of calories increases the lifespan of many different organisms, including mice. Although caloric restriction has not been demonstrated experimentally to increase human lifespan, short-term changes in physiological measures like insulin responsiveness have been observed. Caloric restriction not only increases lifespan, but decreases age-related deterioration of systems and physiological responses, reducing age related diseases like cancer and neurodegenerative disease. Caloric restriction in animals reduces the levels of plasma glucose and insulin and reduces inflammatory responses and may reduce oxidative stress through reduced oxidative metabolism, further contributing to the health benefits of reduced calorie intake. The reduction in inflammation may be related to reduces plasma glucose and in humans could reduce an inflammation connection to cancer, heart disease, and Alzheimer?disease. https://cgap.nci.nih.gov/Pathways/BioCarta/h_longevityPathway PAGER curation team PAGER-contact@googlegroups.com 2761.09090858491 1.0 13-AUG-20 BioCarta P 252
WAG001037 y branching of actin filaments 15 Homo sapiens Mammalian cell motility requires actin polymerization in the direction of movement to change membrane shape and extend cytoplasm into lamellipodia. The polymerization of actin to drive cell movement also involves branching of actin filaments into a network oriented with the growing ends of the fibers near the cell membrane. Manipulation of this process helps bacteria like Salmonella gain entry into cells they infect. Two of the proteins involved in the formation of Y branches and in cell motility are Arp2 and Arp3, both members of a large multiprotein complex containing several other polypeptides as well. The Arp2/3 complex is localized at the Y branch junction and induces actin polymerization. Activity of this complex is regulated by multiple different cell surface receptor sigling systems, activating WASP, and Arp2/3 in turn to cause changes in cell shape and cell motility. Wasp and its cousin Wave-1 interact with the Arp2/3 complex through the p21 component of the complex. The crystal structure of the Arp2/3 complex has revealed further insights into the ture of how the complex works. https://cgap.nci.nih.gov/Pathways/BioCarta/h_actinYPathway PAGER curation team PAGER-contact@googlegroups.com 2029.62972311241 1.0 13-AUG-20 BioCarta P 252
WAG001246 toll-like receptor pathway 35 Homo sapiens The inte immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS, endotoxin), bacterial lipoproteins, peptidoglycans and also CpG nucleic acids activate inte immunity as well as stimulating the antigen-specific immune response and triggering the inflammatory response. Members of the toll-like receptor (TLR) gene family convey sigls stimulated by these factors, activating sigl transduction pathways that result in transcriptiol regulation and stimulate immune function. TLR2 is activated by bacterial lipoproteins, TLR4 is activated by LPS, and TLR9 is activated by CpG D; peptidoglycan recognition protein (PGRP) is activated by peptidoglycan (PGN). The downstream sigling pathways used by these receptors are similar to that used by the IL-1 receptor, activating the IL-1 receptor associated kise (IRAK) through the MyD88 adaptor protein, and sigling through TRAF-6 and protein kise cascades to activate NF-kB and Jun. NF-kB and c-Jun activate transcription of genes such as the proinflammatory cytokines IL-1 and IL-12. Several recent reports have suggested that the functiol outcomes of sigling via TLR2, TLR4 and PGRP are not equivalent. For example, while the LPS-induced, p38-dependent response was dependent upon PU.1 binding, the PGN-induced, p38 response was not. The intracelular receptor for PGN, PGRP is conserved from insects to mammals. In insects, PGRP activates prophenoloxidase cascade, a part of the insect antimicrobial defense system. Because mammals do not have the prophenoloxidase cascade, its function in mammals is unknown. However, it was suggested that an identical protein Tag7 was a tumor necrosis factor-like (TNF-like) cytokine. PGRP/Tag7 possesses cytotoxicity and triggers intranucleosomal D fragmentation in target cells in the same way as many known members of the TNF family. Fragmentation of D is one of the characteristics of apoptosis. The possibility that in another system, PGRP/Tag7 would induce NF-kB activation, as observed for TRAIL (TNF-related apoptosis-inducing ligand) receptors canot be ruled out. https://cgap.nci.nih.gov/Pathways/BioCarta/h_tollPathway PAGER curation team PAGER-contact@googlegroups.com 4502.78730563165 1.0 13-AUG-20 BioCarta P 252
WAG001239 influence of ras and rho proteins on g1 to s transition 25 Homo sapiens The cell cycle transition from G1 to S phase is a key regulatory point in the cell cycle. This transition is regulated by the checkpoint kise cdk2 that activates the G1 to S transition when it is associated with cyclin E. Cdk2/Cyclin E causes the G1 to S transition through phosphorylation of the tumor suppressor Rb, releasing the transcription factor E2F-1. Other pathways acting through Rac, Ras and Rho also regulate the G1 to S transition. Ras regulates cyclin D1 expression to affect the G1 to S transition. Transforming forms of Ras or Raf induce cyclin D1 expression and cause early entry into S phase. Sigling from Ras to Raf to MEK to ERKs induces Cyclin D1 expression, allowing Cyclin D1 to complex with Cdk4 and Cdk6 and phosphorylate Rb. Rac-1 and PAK appear to induce Cyclin D1 expression and induce the G1 to S transition primarily through activation of NF-kB to activate the Cyclin D1 promoter. Rho activates cdk2 and also inhibits p21 and p27 to induce cyclin D1 and stimulate the G1 to S transition. Rho represses p21 expression to block p21 induction by Ras and to allow Ras induced progression from G1 to S. Cells that lack p21 do not require Rho for Ras to induce cell cycle progression from G1 to S phase. The cooperative action of Ras, Rac and Rho to induce Cyclin D1 expression is a key component of oncogenic transformation. https://cgap.nci.nih.gov/Pathways/BioCarta/h_RacCycDPathway PAGER curation team PAGER-contact@googlegroups.com 3592.00213097773 1.0 13-AUG-20 BioCarta P 252
WAG001240 ctcf: first multivalent nuclear factor 15 Homo sapiens CTCF is central to sigling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF? Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic ictivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptiol activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is bo fide ¿ltivalent?D-sequence binder which specificity is mediated by different sets of zinc fingers (ZFs). For three different D target sites, particular groups of ZFs which cannot be deleted from the 11 ZF domain without loosing binding to a given site, are shown by a ¿inbow?in the box on the left. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ctcfPathway PAGER curation team PAGER-contact@googlegroups.com 1369.32047826216 1.0 13-AUG-20 BioCarta P 252
TAX013377 GO:0000347 cellular_component THO complex 6 Homo sapiens The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000347 PAGER curation team PAGER-contact@googlegroups.com 1744.99138319124 2 13-AUG-20 GOA A 21894
TAX013378 GO:0000349 biological_process generation of catalytic spliceosome for first transesterification step 2 Homo sapiens Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000349 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013379 GO:0000350 biological_process generation of catalytic spliceosome for second transesterification step 3 Homo sapiens Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000350 PAGER curation team PAGER-contact@googlegroups.com 79.8458149779736 2 13-AUG-20 GOA A 21894
TAX013380 GO:0000354 biological_process cis assembly of pre-catalytic spliceosome 2 Homo sapiens Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000354 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013381 GO:0000375 biological_process RNA splicing, via transesterification reactions 253 Homo sapiens Splicing of RNA via a series of two transesterification reactions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000375 PAGER curation team PAGER-contact@googlegroups.com 11913.0838063695 2 13-AUG-20 GOA A 21894
TAX013382 GO:0000377 biological_process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 248 Homo sapiens Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000377 PAGER curation team PAGER-contact@googlegroups.com 12210.121381153 2 13-AUG-20 GOA A 21894
WAG001442 Propanoate metabolism 30 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00640 PAGER curation team PAGER-contact@googlegroups.com 932.823745181811 1.0 13-AUG-20 KEGG P 199
TAX013383 GO:0000379 biological_process tRNA-type intron splice site recognition and cleavage 3 Homo sapiens RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000379 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX013384 GO:0000380 biological_process alternative mRNA splicing, via spliceosome 16 Homo sapiens The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000380 PAGER curation team PAGER-contact@googlegroups.com 221.235002093838 2 13-AUG-20 GOA A 21894
TAX013385 GO:0000381 biological_process regulation of alternative mRNA splicing, via spliceosome 44 Homo sapiens Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000381 PAGER curation team PAGER-contact@googlegroups.com 550.663148619147 2 13-AUG-20 GOA A 21894
TAX013386 GO:0000384 molecular_function first spliceosomal transesterification activity 2 Homo sapiens Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000384 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013387 GO:0000386 molecular_function second spliceosomal transesterification activity 3 Homo sapiens Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000386 PAGER curation team PAGER-contact@googlegroups.com 226.45236784141 2 13-AUG-20 GOA A 21894
TAX013388 GO:0000387 biological_process spliceosomal snRNP assembly 37 Homo sapiens The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000387 PAGER curation team PAGER-contact@googlegroups.com 3474.93016998899 2 13-AUG-20 GOA A 21894
TAX013389 GO:0000389 biological_process mRNA 3'-splice site recognition 6 Homo sapiens Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000389 PAGER curation team PAGER-contact@googlegroups.com 214.379132551138 2 13-AUG-20 GOA A 21894
TAX013390 GO:0000390 biological_process spliceosomal complex disassembly 2 Homo sapiens Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000390 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013391 GO:0000394 biological_process RNA splicing, via endonucleolytic cleavage and ligation 10 Homo sapiens Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000394 PAGER curation team PAGER-contact@googlegroups.com 134.847820000747 2 13-AUG-20 GOA A 21894
TAX013392 GO:0000395 biological_process mRNA 5'-splice site recognition 6 Homo sapiens Recognition of the intron 5'-splice site by components of the assembling spliceosome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000395 PAGER curation team PAGER-contact@googlegroups.com 38.857938718663 2 13-AUG-20 GOA A 21894
TAX013393 GO:0000398 biological_process mRNA splicing, via spliceosome 248 Homo sapiens The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000398 PAGER curation team PAGER-contact@googlegroups.com 12210.121381153 2 13-AUG-20 GOA A 21894
WAG001444 Thyroid cancer 23 Homo sapiens Thyroid cancer is the most common endocrine maligncy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05216 PAGER curation team PAGER-contact@googlegroups.com 1037.81997634691 1.0 13-AUG-20 KEGG P 199
WAG001446 beta-Alanine metabolism 41 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00410 PAGER curation team PAGER-contact@googlegroups.com 2067.62060006525 1.0 13-AUG-20 KEGG P 199
WAG001447 Ubiquinone biosynthesis 8 Homo sapiens Ubiquinone (UQ), also called coenzyme Q, and plastoquinone (PQ) are electron carriers in oxidative phosphorylation and photosynthesis, respectively. The quinoid nucleus of ubiquinone is derived from the shikimate pathway; 4-hydroxybenzoate is directly formed from chorismate in bacteria, while it can be formed from either chorismate or tyrosine in yeast. The following biosynthesis of terpenoid moiety involves reactions of prenylation, decarboxylation, and three hydroxylations alterting with three methylations. The order of these reactions are somewhat different between bacteria and yeast. Phylloquinone (vitamin K1), mequinone (vitamin K2), and tocopherol (vitamin E) are fat-soluble vitamins. Phylloquinone is a compound present in all photosynthetic plants serving as a cofactor for photosystem I-mediated electron transport. Mequinone is an obligatory component of the electron-transfer pathway in bacteria. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00130 PAGER curation team PAGER-contact@googlegroups.com 235.867563473297 1.0 13-AUG-20 KEGG P 199
WAG001448 Nonhomologous end joining 12 Homo sapiens Nonhomologous end joining (NHEJ) elimites D double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded D ends, recruitment of D-PKcs (MRX complex in yeast), processing of ends, and recruitment of the D ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and D ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two D DSBs without the need for sequence homology, and so is error-prone. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03450 PAGER curation team PAGER-contact@googlegroups.com 2756.94800864606 1.0 13-AUG-20 KEGG P 199
TAX013394 GO:0000400 molecular_function four-way junction DNA binding 17 Homo sapiens Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000400 PAGER curation team PAGER-contact@googlegroups.com 1204.70547237823 2 13-AUG-20 GOA A 21894
TAX013395 GO:0000403 molecular_function Y-form DNA binding 6 Homo sapiens Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000403 PAGER curation team PAGER-contact@googlegroups.com 416.551095917391 2 13-AUG-20 GOA A 21894
WAG001431 Melanoma 65 Homo sapiens Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignt transformation of pigment-producing cells, melanocytes. The only known environmental risk factor is exposure to ultraviolet (UV) light and in people with fair skin the risk is greatly increased. Melanoma pathogenesis is also driven by genetic factors. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Melanoma development has been shown to be strongly associated with ictivation of the p16INK4a/cyclin dependent kises 4 and 6/retinoblastoma protein (p16INK4a/CDK4,6/pRb) and p14ARF/human double minute 2/p53 (p14ARF/HMD2/p53) tumor suppressor pathways. MITF and TP53 are implicated in further melanoma progression. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05218 PAGER curation team PAGER-contact@googlegroups.com 4305.42530517935 1.0 13-AUG-20 KEGG P 199
WAG001432 Oxidative phosphorylation 89 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00190 PAGER curation team PAGER-contact@googlegroups.com 12900.9697624683 1.0 13-AUG-20 KEGG P 199
TAX013396 GO:0000404 molecular_function heteroduplex DNA loop binding 3 Homo sapiens Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000404 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX013397 GO:0000405 molecular_function bubble DNA binding 7 Homo sapiens Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000405 PAGER curation team PAGER-contact@googlegroups.com 197.476316723873 2 13-AUG-20 GOA A 21894
TAX013398 GO:0000406 molecular_function double-strand/single-strand DNA junction binding 2 Homo sapiens Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000406 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013399 GO:0000407 cellular_component phagophore assembly site 19 Homo sapiens Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000407 PAGER curation team PAGER-contact@googlegroups.com 152.343523623401 2 13-AUG-20 GOA A 21894
TAX013400 GO:0000408 cellular_component EKC/KEOPS complex 6 Homo sapiens A protein complex involved in t6A tRNA modification; originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000408 PAGER curation team PAGER-contact@googlegroups.com 622.855118032695 2 13-AUG-20 GOA A 21894
TAX013402 GO:0000411 biological_process positive regulation of transcription by galactose 1 Homo sapiens Any process involving galactose that activates or increases the rate of transcription. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000411 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013403 GO:0000413 biological_process protein peptidyl-prolyl isomerization 40 Homo sapiens The modification of a protein by cis-trans isomerization of a proline residue. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000413 PAGER curation team PAGER-contact@googlegroups.com 384.052298781019 2 13-AUG-20 GOA A 21894
WAG001443 Pyruvate metabolism 55 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00620 PAGER curation team PAGER-contact@googlegroups.com 1952.94550415636 1.0 13-AUG-20 KEGG P 199
TAX013404 GO:0000414 biological_process regulation of histone H3-K36 methylation 6 Homo sapiens Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000414 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013405 GO:0000415 biological_process negative regulation of histone H3-K36 methylation 1 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000415 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013406 GO:0000416 biological_process positive regulation of histone H3-K36 methylation 3 Homo sapiens Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000416 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013407 GO:0000421 cellular_component autophagosome membrane 29 Homo sapiens The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000421 PAGER curation team PAGER-contact@googlegroups.com 139.058188824154 2 13-AUG-20 GOA A 21894
TAX013408 GO:0000422 biological_process autophagy of mitochondrion 43 Homo sapiens The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000422 PAGER curation team PAGER-contact@googlegroups.com 1005.24078308785 2 13-AUG-20 GOA A 21894
TAX013409 GO:0000423 biological_process mitophagy 6 Homo sapiens Degradation of a mitochondrion by macroautophagy. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000423 PAGER curation team PAGER-contact@googlegroups.com 164.518021440027 2 13-AUG-20 GOA A 21894
TAX013412 GO:0000430 biological_process regulation of transcription from RNA polymerase II promoter by glucose 3 Homo sapiens Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000430 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX013413 GO:0000431 biological_process regulation of transcription from RNA polymerase II promoter by galactose 1 Homo sapiens Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000431 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG001457 eicosanoid metabolism 17 Homo sapiens The eicosanoids are a family of lipophilic hormones derived from the twenty carbon fatty acid arachidonic acid. Although they are diverse in structure, many eicosanoids have roles in inflammation, including regulation of vasodilation, vascular permeability, pain, and recruitment of leukocytes. Most members of this family are rapidly metabolized near their site of synthesis, so they act locally on neighboring cells, not distant parts of the body. They are also not stored in cells, but synthesized rapidly in response to stimuli, making regulation of their synthesis a key to their activity. Many drugs act through modulating the production of eicosanoids or modulating their sigling pathways. Hormones in the eicosanoid family include the prostaglandins, thromboxanes, leukotrienes, and prostacyclins. The first step in the production of eicosanoids is the release of arachidonic acid from either diacylglycerol or phospholipids by membrane bound phospholipases in response to extracellular stimuli. Arachidonic acid has several possible fates, including oxygetion by lipoxygeses to make HPETEs (hydroperoxy-eicosatetraenoic acids), or production of prostaglandin H2 by PGH2 synthase. 5-lipoxygese acts with the membrane bound protein FLAP (five lipoxygese activating protein) to produce the epoxide leukotriene LTA4 which is hydrolyzed to produce LTB4 or has glutathione added by a glutathione S-transferase to produce LTC4 and LTD4. A G-protein coupled receptor for LTD4, CysLT1, mediates an important component of the inflammatory response of leukotrienes on airway constriction and recruitment of leukocytes, and several marketed asthma drugs act as antagonists of the CysLT1 receptor. PGH2 synthase actually consists of two enzyme components, a cyclooxygese and a peroxidase, and there are more than one type of cycloxygese, including Cox-1 and Cox-2. Recent NSAIDS acting selectively as Cox-2 inhibitors like Vioxx are widely used for the treatment of arthritis and other inflammatory conditions, inhibiting the production of downstream thromboxanes and prostaglandins. PGH2 also has several possible fates, including conversion by thromboxane synthase to Tpx2, an eicosinoid with potent coagulation and vasoconstriction activity. PGI2, or prostacyclin, synthesized by prostacyclin synthase, has properties opposite those of thromboxane, causing vasodilation and a reduction in clotting through the IP receptor, causing thromboxanes and PGI2 to act in opposition to each other. Thromboxane antagonists and prostacyclin agonists both provide tools and drugs to reduce vasoconstriction. The prostaglandins include PGD2, PGE2 and PGF2, with varying degrees of selectivity among their receptors, DP, EP and FP, respectively. PGE2 exerts biological effects including induction of pain, fever and vasodilation through at least four receptors, EP1, EP2, EP3 and EP4, and EP3 is found in multiple splice variants. The diversity of the eicosanoids and their receptors and their involvement in many disease states makes it likely that this pathway will continue as a major research focus. https://cgap.nci.nih.gov/Pathways/BioCarta/h_eicosanoidPathway PAGER curation team PAGER-contact@googlegroups.com 575.912457076662 1.0 13-AUG-20 BioCarta P 252
WAG001038 stathmin and breast cancer resistance to antimicrotubule agents 12 Homo sapiens Stathmin is a ubiquitous, cytosolic 19-kDa protein, which is phosphorylated on up to four sites in response to many regulatory sigls within cells. Its molecular characterization indicates a functiol organization including an N-termil regulatory domain that bears the phosphorylation sites, linked to a putative alpha-helical binding domain predicted to participate in coiled-coil, protein-protein interactions. In addtion to the protein kises that phospjhorylate Stathmin such as CaMK, MAPK, p34cdc2, PKA, a few other proteins have been suggested to interact with stathmin in vivo. One of them was identified as BiP, a member of the hsp70 heat-shock protein family. Another is a previously unidentified, putative serine/threonine kise, KIS, which might be regulated by stathmin or, more likely, be part of the kises controlling its phosphorylation state. Filly, two proteins, CC1 and CC2, predicted to form alpha-helices participating in coiled-coil interacting structures. It has been also suggest that the action of antimicrotubule drugs can be affected by stathmin in at least two ways: (a) altered drug binding; and (b) growth arrest at the G2 to M boundary. Mutant p53 breast cancers exhibiting high levels of stathmin may be resistant to antimicrotubule agents. https://cgap.nci.nih.gov/Pathways/BioCarta/h_stathminPathway PAGER curation team PAGER-contact@googlegroups.com 1460.70113019684 1.0 13-AUG-20 BioCarta P 252
WAG001238 role of nicotinic acetylcholine receptors in the regulation of apoptosis 17 Homo sapiens Nicotinic acetylcholine receptors are essential for neuromuscular sigling and are also expressed in non-neurol tissues, where their function is less clear. Although nicotinic acetylcholine receptors are primarily known for their action as ligand-gated ion channels transducing action potentials across sypses, they may have other actions. Nicotinic acetylcholine receptors in neurons alter apoptotic sigling, protecting against cell death in some settings, and this action may in some cases be directed through altertive sigling pathways. In neurons the alpha-7 nicotinic receptor activates PI3 kise through a src-family kise, activating the anti-apoptotic kise AKT (See ¿T sigling pathway?. One pathway involved in AKT sigling involves phosphorylation of the forkhead transcription factor FKHRL1, causing its retention in the cytoplasm associated with 14-3-3, and blocking expression of the apoptotic fas protein. The PI3 kise/AKT pathway protects a broad range of neurons against apoptotic cell death and may block apoptosis triggered by beta-amyloid fragments that contributes to the progression of Alzheimer?disease. If so, nicotinic agents may prove useful in the treatment of this and other neurodegenerative conditions. https://cgap.nci.nih.gov/Pathways/BioCarta/h_achPathway PAGER curation team PAGER-contact@googlegroups.com 762.652782787335 1.0 13-AUG-20 BioCarta P 252
WAG001458 il-2 receptor beta chain in t cell activation 40 Homo sapiens The IL-2 receptor is a key component of immune sigling and is required for the activation, proliferation, and survival of T cells. This receptor is composed of three polypeptide chains, the alpha, beta and gamma chains. The IL-2 receptor gamma chain is a common component for several other cytokine receptors, including IL-4, IL-7, IL-9 and IL-15. The IL-2 receptor beta chain is essential for IL-2 sigling and is also a component of the IL-15 receptor complex. The polypeptides of the IL-2 receptor do not themselves have intrinsic catalytic activity, but interact with cytoplasmic sigling proteins to transduce sigls. https://cgap.nci.nih.gov/Pathways/BioCarta/h_il2rbPathway PAGER curation team PAGER-contact@googlegroups.com 5511.12926923465 1.0 13-AUG-20 BioCarta P 252
WAG001459 aspirin blocks signaling pathway involved in platelet activation 15 Homo sapiens Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4 are cleaved by the protease thrombin, releasing a tethered peptide ligand that activates the receptor and triggers intracellular calcium release. Platelets from mice lacking the PAR4 gene are not activated by thrombin and are impaired in clotting, supporting the importance of thrombin sigling through PAR4 in clotting. Human platelets express both PAR1 and PAR4, with PAR1 playing a more domint role in clotting in humans. Calcium release induced by PARs activates PKC, modulating integrin alpha IIB beta 3 (glycoprotein IIb/IIIa) and opening integrin ligand binding sites to contribute to platelet aggregation. Intracellular calcium increases induced by thrombin activates phospholipase A2, liberating arachidonic acid, the first step in prostaglandin and thromboxane biosynthesis. Ras/Map kise activation by the PAR receptors also activates phospholipase A2. The activation of PAR-induced platelet aggregation is inhibited by aspirin, indicating that thromboxane production induced by PAR sigling contributes to platelet activation. Arachidonic acid is converted to the prostaglandin PGG2 by the enzyme Cox-1 in platelets, and Cox-1 is inhibited by aspirin, reducing thromboxane A2 production by platelets. Thromboxane is a potent vasoconstrictor and platelet activator, so inhibition of Cox-1 in platelets by aspirin may explain some of the cardioprotective actions of aspirin. https://cgap.nci.nih.gov/Pathways/BioCarta/h_sppaPathway PAGER curation team PAGER-contact@googlegroups.com 1763.7012342878 1.0 13-AUG-20 BioCarta P 252
WAG001460 b cell survival pathway 11 Homo sapiens Physical interactions between intergrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignt B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, surviving, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction. https://cgap.nci.nih.gov/Pathways/BioCarta/h_bcellsurvivalPathway PAGER curation team PAGER-contact@googlegroups.com 535.586788309419 1.0 13-AUG-20 BioCarta P 252
WAG001474 mechanism of acetaminophen activity and toxicity 4 Homo sapiens Acetaminophen is one of the worlds most commonly used drugs, used for the treatment of pain and fever. Like other NSAIDs (non-steroidal anti-inflammatory drugs), acetaminophen has a unique activity profile based in part on its action at its molecular targets, the cyclooxygese enzymes that produce prostaglandins responsible for pain, fever and inflammation. Until very recently, only two Cox enzymes, Cox-1 and Cox-2, were known to be targets of NSAIDS. Cox-1 is expressed in a constitutive manner throughout most tissues, and plays an essential role in maintaining the integrity of the stomach mucosal lining. Cox-2 is an inducible enzyme whose expression is induced by inflammation. NSAIDS selective for Cox-2 have been developed to avoid the development of ulcers by some non-selective NSAIDs, including aspirin. While these two isoforms were sufficient to account for most NSAIDs pharmacology, the actions of acetaminophen remained hard to explain on the basis of inhibiting Cox-1 and Cox-2 alone, such as its efficacy at reducing pain and fever but lack of anti-inflammatory effects. A novel Cox enzyme isoform encoded by the Cox-1 gene, Cox-3, contains an additiol 30-34 amino acids and is expressed selectively in the brain. This insertion alters the pharmacology of the Cox enzyme, making Cox-3 sensitive to selective inhibition by acetaminophen and other drugs that reduce pain and fever but have weak anti-inflammatory activity, explaining the pharmacology of these drugs. https://cgap.nci.nih.gov/Pathways/BioCarta/h_AcetaminophenPathway PAGER curation team PAGER-contact@googlegroups.com 188.558607956135 1.0 13-AUG-20 BioCarta P 252
WAG001475 role of ran in mitotic spindle regulation 10 Homo sapiens One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes are not just passengers along for a ride with the spindle, but active participants in the nucleation and stabilization of spindle microtubules in their near vicinity. The ras-like GTPase Ran that regulates nucleocytoplasmic transport through the nuclear pore complex (NPC) during interphase (See ¿le of Ran in Nucleocytoplasmic Transport?Pathway) also regulates the formation of the mitotic spindle. Ran plays a similar role in each of these processes, regulating downstream sigling pathways in a differential manner based on whether GDP or GTP is bound. Like other GTPases, the inherent GTPase activity of Ran is regulated by GTPase activating proteins (GAPs) and by exchange factors. An exchange factor that stimulates nucleotide exchange by the Ran GTPase is RCC1, which binds to chromatin in both interphase and mitosis. While RCC1 helps RAN drive transport between the nucleus and cytoplasm during interphase, the localization of RCC1 on chromatin during mitosis localizes Ran-GTP near chromosomes, localizing microtubule formation in these regions. Ran-BP1 and Ran-GAP1 stimulate GTP hydrolysis by Ran, converting it back to Ran-GDP further away from chromosomes. Aster promoting activities (APA) and the importin-alpha and importin-beta proteins involved with Ran in nucleocytoplasmic transport are also involved in mitotic spindle formation. Aster promoting activities stabilize microtubules during spindle formation, but binding of importins to APA neutralizes their activity in forming microtubules. The importins bind to APA when far from the chromosomes, where Ran-GDP predomites, but Ran-GTP near chromosomes causes importins to release APA factors including Tpx2 and NuMa, allowing them to stimulate microtubule formation. Tpx2 interacts with the microtubule motor protein Xklp2 and also activates the Aurora A mitotic kise, required for spindle formation. In addition to regulating spindle formation, Ran may also help reform the nuclear envelope after cell division and may use a similar mechanism to regulate other cellular processes. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ranMSpathway PAGER curation team PAGER-contact@googlegroups.com 940.394938220912 1.0 13-AUG-20 BioCarta P 252
WAG001461 skeletal muscle hypertrophy is regulated via akt-mtor pathway 24 Homo sapiens Skeletal muscle atrophies with disuse while with increased use and increased load skeletal muscle exhibits hypertrophy, with an increase in the size of existing muscle fibers. One sigling pathway involved in regulating skeletal muscle atrophy and hypertrophy is the AKT/mTOR pathway (see mTOR pathway). The mTOR pathway activity increases in response to muscle activity during hypertrophy and decreases in activity during atrophy. Blocking this pathway genetically or with the mTOR inhibitor rapamycin blocks hypertrophy and genetic activation of the pathway induces hypertrophy. One agent that promotes muscle hypertrophy is the growth factor IGF-1. IGF-1 activates AKT, GSK-3beta and mTOR to promote hypertrophy. In contrast, the calcineurin pathway is not involved in hypertrophy and is down-regulated by agents such as IGF-1 that promote hypertrophy. Calcineurin may modulate other aspects of muscle function such as the development of slow muscle fibers through transcriptiol regulation. These pathways lead to regulation of protein translation, with increased translation apparently acting as a key regulatory point in skeletal muscle hypertrophy. Agents such as IGF-1 that stimulate skeletal muscle hypertrophy may provide treatments for muscle atrophy and wasting. https://cgap.nci.nih.gov/Pathways/BioCarta/h_igf1mtorpathway PAGER curation team PAGER-contact@googlegroups.com 1638.35006565445 1.0 13-AUG-20 BioCarta P 252
WAG001462 signal transduction through il1r 30 Homo sapiens Interleukin-1 (IL-1) is a pro-inflammatory cytokine that sigls primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include induction of fever, expression of vascular adhesion molecules, and roles in arthritis and septic shock. The inflammatory activities of IL-1 are partially derived by transcriptiolly inducing expression of cytokines such as TNF-alpha and interferons, as well as inducing the expression of other inflammation-related genes. There are two forms of IL-1 encoded by distinct genes, IL-1 alpha and IL-1 beta. IL-1 beta is produced as a 269 amino acid precursor that is cleaved by IL-1beta converting enzyme (ICE) to the active IL-1 beta form that is secreted. IL-1 sigling is opposed by the turally occurring peptide IL-1 receptor antagonist which is a therapeutic agent for the treatment of arthritis. https://cgap.nci.nih.gov/Pathways/BioCarta/h_il1rPathway PAGER curation team PAGER-contact@googlegroups.com 4204.55231167116 1.0 13-AUG-20 BioCarta P 252
WAG001463 wnt lrp6 signalling 5 Homo sapiens Wnt glycoproteins play a role in diverse processes during embryonic patterning in metazoa through interaction with frizzled-type seven-transmembrane-domain receptors (Frz) to stabilize b-catenin. LDL-receptor-related protein 6 (LRP6), a Wnt co-receptor, is required for this interaction. Dikkopf (dkk) proteins are both positive and negative modulators of this sigling. https://cgap.nci.nih.gov/Pathways/BioCarta/h_wnt-lrp6Pathway PAGER curation team PAGER-contact@googlegroups.com 882.508700274157 1.0 13-AUG-20 BioCarta P 252
WAG001464 multi-step regulation of transcription by pitx2 22 Homo sapiens Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordited transcriptiol control of proliferation in specific developmental cell types is crucial in multiple developmental settings. One of a family of three bicoid-related transcription factors, Pitx2 acts downstream of the extracellular sigling protein Wnt to drive proliferation of cells with specific developmental fates, including cells in the pituitary, cardiac outflow region, and muscle. Wnt binds to Frizzled, a G-protein coupled receptor, activating homologs of the Drosophila Disheveled protein. Activation of Frizzled and Disheveled inhibits the kise GSK-3 beta, part of a protein complex in the absence of Wnt sigling, causing beta-catenin protein to accumulate in the cytoplasm. Beta-catenin is known to alter the function of transcription factors like TCF/Lef. One result of Wnt sigling is activation of the transcription factor Lef by beta-catenin, inducing Pitx2 expression. Wnt activation also changes Pitx2 from a repressor to an activator by causing transcriptiol corepressors like histone deacetylase 1 (HDAC1) bound to Pitx2 to be exchanged for coactivators. With coactivators bound, Pitx2 activates transcription of genes that regulate the cell cycle like Cyclin D2. Different coactivators are recruited by Pitx2 and other transcription factors like Myc to the Cyclin D2 promoter, with CBP/p300 recruited first, followed by NLI/Ldb/CLIM, Tip60/TRRAP, and PBP coactivators. Many of these coactivators help to alter histone acetylation and chromatin structure as part of transcriptiol activation. The activation of cell cycle genes by Pitx2 ultimately stimulates the proliferation of specific cell types with the confluence of tissue-specific gene expression, growth factor sigling and coactivator recruitment. https://cgap.nci.nih.gov/Pathways/BioCarta/h_pitx2Pathway PAGER curation team PAGER-contact@googlegroups.com 1283.94884135904 1.0 13-AUG-20 BioCarta P 252
WAG001465 ccr3 signaling in eosinophils 20 Homo sapiens Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response in inflammation is absent in mice lacking CCR3, indicating the key role of this G protein coupled receptor in inflammation and allergic responses. Eotaxin is a chemokine ligand for CCR3 that recruits eosinophils to the site of inflammation and activates them. Other chemokine ligands of CCR3 include eotaxin-2, MCP-3, MCP-4, and RANTES. Multiple sigling pathways activated by CCR3 participate in the inflammatory response of eosinophils. Eotaxin stimulates intracellular calcium release, production of reactive oxygen species, and changes in actin polymerization through a pertussis sensitive pathway. Rho and ROCK regulate actin stress fiber formation and are required for eosinophil chemotaxis. Rho is a G protein that activates ROCK, a protein kise. Map kise pathways are also involved in chemotaxis. Another key action of activated eosinophils is the release of reactive oxygen species, causing tissue damage during chronic inflammatory responses. Blocking eosinophil activation and the sigling pathways that lead to chemotaxis, degranulation and reactive oxygen release may alleviate inflammatory conditions and inflammation-associated tissue damage. https://cgap.nci.nih.gov/Pathways/BioCarta/h_CCR3Pathway PAGER curation team PAGER-contact@googlegroups.com 1020.32497077163 1.0 13-AUG-20 BioCarta P 252
WAG001466 overview of telomerase protein component gene htert transcriptional regulation 10 Homo sapiens Telomerase is an enzyme which replicates the termil sequences of eukaryotic chromosomes, mely the telomeres. Cells which have an unlimited replicative capacity such as male germ cells and the majority of human cancers have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential R subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase R gene (hTERC) are controlled at least in part at the transcriptiol level. The hTERC gene is expressed at high levels in cancer cells, and is absent or at low levels in some normal tissues. https://cgap.nci.nih.gov/Pathways/BioCarta/h_tercPathway PAGER curation team PAGER-contact@googlegroups.com 1607.32558139535 1.0 13-AUG-20 BioCarta P 252
WAG001467 nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells 13 Homo sapiens RXR and RAR are nuclear receptors that bind either all trans retinoic (tRA) or 9cis retinoic acid (9cisRA). In the absence of ligand corepressors with histone deacetylase activity are bound to the RAR/RXR hetrodimer and suppress transcription. Once they bind retinoic acid a conformatiol change in the receptors cause the dissociation of the corepressors and the binding of coactivators with histone acetylase activity (1). Following ligand binding by the hetrodimer the receptors and proteins in the basal transcription machinery (like TBP and TAF135) are degraded by the proteasome (2). https://cgap.nci.nih.gov/Pathways/BioCarta/h_rarrxrPathway PAGER curation team PAGER-contact@googlegroups.com 1561.19573031978 1.0 13-AUG-20 BioCarta P 252
WAG001468 il-7 signal transduction 12 Homo sapiens IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T cells. Some humans with SCID (severe combined immunodeficiency disease) also have mutation of their IL-7 receptor gene leading to an absence of T cells and greatly impaired B cell production. The IL-7 receptor includes two polypeptides, a gamma chain and an alpha chain. The alpha-chain is unique to the IL-7 receptor while several other cytokines use the same gamma receptor chain as IL-7, including IL-2, IL-4, IL-9, IL-15 and IL-21. Binding of IL-7 to the alpha chain leads to dimerization of the alpha and gamma chains. JAK3 associated with the gamma chain tyrosine phosphorylates the alpha chain after dimerization. The importance of JAK3 in IL-7 sigling is supported by the similarity of the immune defects in JAK3 knockout mice and IL-7 knockout mice. The phosphorylated alpha chain serves as the site for recruiting other sigling molecules to the complex to be phosphorylated and activated, including STAT5, src kises, PI3 kise, Pyk2 and Bcl2 proteins. Some targets of IL-7 sigling contribute to cellular survival, including Bcl2 and Pyk2. Other targets contribute to cellular proliferation, including PI3 kise, src family kises (lck and fyn) and STAT5. The transcription factor STAT5 contributes to activation of multiple different downstream genes in B and T cells and may contribute to VDJ recombition through alteration of chromatin structure. The cell survival and cell proliferation sigls induced by IL-7 combine to induce normal B and T cell development. https://cgap.nci.nih.gov/Pathways/BioCarta/h_il7Pathway PAGER curation team PAGER-contact@googlegroups.com 1658.32080114054 1.0 13-AUG-20 BioCarta P 252
WAG001469 basic mechanisms of sumoylation 6 Homo sapiens Like ubiquitin, SUMO (small ubiquitin-related modifier) proteins are small protein tags that are conjugated to proteins to modify their function. The ubiquitin system tags proteins for degradation by the proteosome (see Proteosome pathway) but SUMO conjugation has a range of other functions, stabilizing some proteins and altering their subcellular localization. Sumoylation may also influence ubiquitition and protein stability indirectly. Three different SUMO proteins are conjugated to proteins, SUMO-1, SUMO-2 and SUMO-3. The SUMO-2 and SUMO-3 genes are closely related, with 86% sequence identity while SUMO-1 is less closely related with about 50% sequence identity with SUMO-2 and SUMO-3. These SUMO proteins also have distinct functions, with SUMO-1 conjugated to proteins as a monomer, while SUMO-2 and SUMO-3 are conjugated to proteins as higher molecular weight polymers with SUMO-1 termiting further SUMO addition. SUMO proteins are first activated by adenylation by one enzyme complex (SAE1/SAE2), then transferred to Ubc-9 and filly to the termil amino group of a lysine side chain in target proteins. The same conjugation system appears to work for all three SUMO proteins. https://cgap.nci.nih.gov/Pathways/BioCarta/h_sumoPathway PAGER curation team PAGER-contact@googlegroups.com 1744.99138319124 1.0 13-AUG-20 BioCarta P 252
TAX013414 GO:0000432 biological_process positive regulation of transcription from RNA polymerase II promoter by glucose 3 Homo sapiens Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000432 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX013415 GO:0000435 biological_process positive regulation of transcription from RNA polymerase II promoter by galactose 1 Homo sapiens Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000435 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013416 GO:0000436 biological_process carbon catabolite activation of transcription from RNA polymerase II promoter 4 Homo sapiens Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000436 PAGER curation team PAGER-contact@googlegroups.com 79.8458149779736 2 13-AUG-20 GOA A 21894
TAX013417 GO:0000438 cellular_component core TFIIH complex portion of holo TFIIH complex 3 Homo sapiens The core TFIIH complex when it is part of the general transcription factor TFIIH. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000438 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX013401 GO:0000409 biological_process regulation of transcription by galactose 1 Homo sapiens Any process involving galactose that modulates the frequency, rate or extent or transcription. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000409 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013418 GO:0000439 cellular_component core TFIIH complex 8 Homo sapiens The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000439 PAGER curation team PAGER-contact@googlegroups.com 1744.59486212349 2 13-AUG-20 GOA A 21894
TAX013419 GO:0000444 cellular_component MIS12/MIND type complex 5 Homo sapiens A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000444 PAGER curation team PAGER-contact@googlegroups.com 490.957645610698 2 13-AUG-20 GOA A 21894
TAX013420 GO:0000445 cellular_component THO complex part of transcription export complex 6 Homo sapiens The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000445 PAGER curation team PAGER-contact@googlegroups.com 1744.99138319124 2 13-AUG-20 GOA A 21894
TAX013421 GO:0000447 biological_process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 9 Homo sapiens Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000447 PAGER curation team PAGER-contact@googlegroups.com 275.934028316501 2 13-AUG-20 GOA A 21894
TAX013422 GO:0000448 biological_process cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2 Homo sapiens Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000448 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013423 GO:0000451 biological_process rRNA 2'-O-methylation 5 Homo sapiens The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000451 PAGER curation team PAGER-contact@googlegroups.com 23.9931740614334 2 13-AUG-20 GOA A 21894
TAX013425 GO:0000454 biological_process snoRNA guided rRNA pseudouridine synthesis 3 Homo sapiens The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000454 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX013426 GO:0000455 biological_process enzyme-directed rRNA pseudouridine synthesis 3 Homo sapiens The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000455 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX013427 GO:0000459 biological_process exonucleolytic trimming involved in rRNA processing 5 Homo sapiens Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000459 PAGER curation team PAGER-contact@googlegroups.com 1216.80585240307 2 13-AUG-20 GOA A 21894
TAX013429 GO:0000461 biological_process endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 2 Homo sapiens Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000461 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013430 GO:0000462 biological_process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 30 Homo sapiens Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000462 PAGER curation team PAGER-contact@googlegroups.com 4905.8730632774 2 13-AUG-20 GOA A 21894
TAX013272 GO:0000138 cellular_component Golgi trans cisterna 7 Homo sapiens The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000138 PAGER curation team PAGER-contact@googlegroups.com 12.8588235294118 2 13-AUG-20 GOA A 21894
TAX013273 GO:0000139 cellular_component Golgi membrane 674 Homo sapiens The lipid bilayer surrounding any of the compartments of the Golgi apparatus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000139 PAGER curation team PAGER-contact@googlegroups.com 129.084953773349 2 13-AUG-20 GOA A 21894
TAX013274 GO:0000145 cellular_component exocyst 18 Homo sapiens A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000145 PAGER curation team PAGER-contact@googlegroups.com 1199.67138895115 2 13-AUG-20 GOA A 21894
TAX013275 GO:0000146 molecular_function microfilament motor activity 21 Homo sapiens Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000146 PAGER curation team PAGER-contact@googlegroups.com 495.405715367231 2 13-AUG-20 GOA A 21894
TAX013276 GO:0000149 molecular_function SNARE binding 128 Homo sapiens Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000149 PAGER curation team PAGER-contact@googlegroups.com 940.528678272996 2 13-AUG-20 GOA A 21894
WAG001440 Toll-like receptor signaling pathway 94 Homo sapiens Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating inte immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on inte immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of inte immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR sigling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04620 PAGER curation team PAGER-contact@googlegroups.com 4045.45631167141 1.0 13-AUG-20 KEGG P 199
WAG001441 1,4-Dichlorobenzene degradation 21 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00627 PAGER curation team PAGER-contact@googlegroups.com 1042.88840170549 1.0 13-AUG-20 KEGG P 199
TAX013277 GO:0000150 molecular_function recombinase activity 8 Homo sapiens Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000150 PAGER curation team PAGER-contact@googlegroups.com 1171.55971969129 2 13-AUG-20 GOA A 21894
TAX013278 GO:0000151 cellular_component ubiquitin ligase complex 304 Homo sapiens A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000151 PAGER curation team PAGER-contact@googlegroups.com 469.025141266346 2 13-AUG-20 GOA A 21894
TAX013279 GO:0000152 cellular_component nuclear ubiquitin ligase complex 40 Homo sapiens A ubiquitin ligase complex found in the nucleus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000152 PAGER curation team PAGER-contact@googlegroups.com 5085.11703778886 2 13-AUG-20 GOA A 21894
TAX013280 GO:0000153 cellular_component cytoplasmic ubiquitin ligase complex 12 Homo sapiens A ubiquitin ligase complex found in the cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000153 PAGER curation team PAGER-contact@googlegroups.com 217.39705447168 2 13-AUG-20 GOA A 21894
TAX013281 GO:0000154 biological_process rRNA modification 39 Homo sapiens The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000154 PAGER curation team PAGER-contact@googlegroups.com 363.429070382165 2 13-AUG-20 GOA A 21894
TAX013282 GO:0000155 molecular_function phosphorelay sensor kinase activity 6 Homo sapiens Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000155 PAGER curation team PAGER-contact@googlegroups.com 1263.08460172802 2 13-AUG-20 GOA A 21894
TAX013283 GO:0000159 cellular_component protein phosphatase type 2A complex 21 Homo sapiens A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000159 PAGER curation team PAGER-contact@googlegroups.com 3479.77257222569 2 13-AUG-20 GOA A 21894
TAX013285 GO:0000164 cellular_component protein phosphatase type 1 complex 14 Homo sapiens A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000164 PAGER curation team PAGER-contact@googlegroups.com 367.188344217311 2 13-AUG-20 GOA A 21894
TAX013286 GO:0000165 biological_process MAPK cascade 294 Homo sapiens An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000165 PAGER curation team PAGER-contact@googlegroups.com 1585.90221875176 2 13-AUG-20 GOA A 21894
TAX013288 GO:0000170 molecular_function sphingosine hydroxylase activity 1 Homo sapiens Catalysis of the hydroxylation of sphingolipid long chain bases. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000170 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013289 GO:0000171 molecular_function ribonuclease MRP activity 2 Homo sapiens Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000171 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013290 GO:0000172 cellular_component ribonuclease MRP complex 6 Homo sapiens A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000172 PAGER curation team PAGER-contact@googlegroups.com 1744.99138319124 2 13-AUG-20 GOA A 21894
TAX013291 GO:0000173 biological_process inactivation of MAPK activity involved in osmosensory signaling pathway 1 Homo sapiens Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000173 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013292 GO:0000175 molecular_function 3'-5'-exoribonuclease activity 30 Homo sapiens Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000175 PAGER curation team PAGER-contact@googlegroups.com 797.242421559241 2 13-AUG-20 GOA A 21894
TAX013293 GO:0000176 cellular_component nuclear exosome (RNase complex) 16 Homo sapiens A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000176 PAGER curation team PAGER-contact@googlegroups.com 4111.77818644039 2 13-AUG-20 GOA A 21894
TAX013294 GO:0000177 cellular_component cytoplasmic exosome (RNase complex) 13 Homo sapiens A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000177 PAGER curation team PAGER-contact@googlegroups.com 4752.68881038764 2 13-AUG-20 GOA A 21894
TAX013295 GO:0000178 cellular_component exosome (RNase complex) 26 Homo sapiens A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000178 PAGER curation team PAGER-contact@googlegroups.com 4871.1667543404 2 13-AUG-20 GOA A 21894
TAX013296 GO:0000179 molecular_function rRNA (adenine-N6,N6-)-dimethyltransferase activity 4 Homo sapiens Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000179 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013297 GO:0000182 molecular_function rDNA binding 9 Homo sapiens Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000182 PAGER curation team PAGER-contact@googlegroups.com 127.984153943783 2 13-AUG-20 GOA A 21894
TAX013298 GO:0000183 biological_process chromatin silencing at rDNA 8 Homo sapiens Repression of transcription of ribosomal DNA by altering the structure of chromatin. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000183 PAGER curation team PAGER-contact@googlegroups.com 307.841186074319 2 13-AUG-20 GOA A 21894
TAX013299 GO:0000184 biological_process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 117 Homo sapiens The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000184 PAGER curation team PAGER-contact@googlegroups.com 40474.1027218039 2 13-AUG-20 GOA A 21894
TAX013300 GO:0000185 biological_process activation of MAPKKK activity 18 Homo sapiens Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000185 PAGER curation team PAGER-contact@googlegroups.com 188.585115772344 2 13-AUG-20 GOA A 21894
TAX013301 GO:0000186 biological_process activation of MAPKK activity 51 Homo sapiens The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000186 PAGER curation team PAGER-contact@googlegroups.com 290.305822169589 2 13-AUG-20 GOA A 21894
TAX013302 GO:0000187 biological_process activation of MAPK activity 148 Homo sapiens The initiation of the activity of the inactive enzyme MAP kinase (MAPK). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000187 PAGER curation team PAGER-contact@googlegroups.com 827.635938549978 2 13-AUG-20 GOA A 21894
TAX013303 GO:0000188 biological_process inactivation of MAPK activity 26 Homo sapiens Any process that terminates the activity of the active enzyme MAP kinase. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000188 PAGER curation team PAGER-contact@googlegroups.com 190.94857852632 2 13-AUG-20 GOA A 21894
TAX013304 GO:0000209 biological_process protein polyubiquitination 237 Homo sapiens Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000209 PAGER curation team PAGER-contact@googlegroups.com 884.345470839327 2 13-AUG-20 GOA A 21894
TAX013305 GO:0000210 molecular_function NAD+ diphosphatase activity 1 Homo sapiens Catalysis of the reaction: NAD+ + H2O = AMP + NMN. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000210 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013431 GO:0000463 biological_process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 9 Homo sapiens Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000463 PAGER curation team PAGER-contact@googlegroups.com 2707.73681021936 2 13-AUG-20 GOA A 21894
TAX013432 GO:0000466 biological_process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 4 Homo sapiens Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000466 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 2 13-AUG-20 GOA A 21894
TAX013433 GO:0000467 biological_process exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 5 Homo sapiens Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000467 PAGER curation team PAGER-contact@googlegroups.com 1216.80585240307 2 13-AUG-20 GOA A 21894
TAX013435 GO:0000470 biological_process maturation of LSU-rRNA 23 Homo sapiens Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000470 PAGER curation team PAGER-contact@googlegroups.com 4964.71820621431 2 13-AUG-20 GOA A 21894
TAX013436 GO:0000472 biological_process endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3 Homo sapiens Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000472 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX013205 GO:0000002 biological_process mitochondrial genome maintenance 12 Homo sapiens The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000002 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013206 GO:0000003 biological_process reproduction 10 Homo sapiens The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000003 PAGER curation team PAGER-contact@googlegroups.com 95.3536339542349 2 13-AUG-20 GOA A 21894
TAX013207 GO:0000009 molecular_function alpha-1,6-mannosyltransferase activity 1 Homo sapiens Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000009 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013208 GO:0000010 molecular_function trans-hexaprenyltranstransferase activity 2 Homo sapiens Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000010 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013209 GO:0000011 biological_process vacuole inheritance 1 Homo sapiens The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000011 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013210 GO:0000012 biological_process single strand break repair 7 Homo sapiens The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000012 PAGER curation team PAGER-contact@googlegroups.com 239.687539661801 2 13-AUG-20 GOA A 21894
TAX013211 GO:0000014 molecular_function single-stranded DNA endodeoxyribonuclease activity 8 Homo sapiens Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000014 PAGER curation team PAGER-contact@googlegroups.com 164.246854566406 2 13-AUG-20 GOA A 21894
TAX013212 GO:0000015 cellular_component phosphopyruvate hydratase complex 4 Homo sapiens A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000015 PAGER curation team PAGER-contact@googlegroups.com 79.8458149779736 2 13-AUG-20 GOA A 21894
TAX013213 GO:0000016 molecular_function lactase activity 1 Homo sapiens Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000016 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013214 GO:0000018 biological_process regulation of DNA recombination 81 Homo sapiens Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000018 PAGER curation team PAGER-contact@googlegroups.com 221.667478693324 2 13-AUG-20 GOA A 21894
TAX013215 GO:0000019 biological_process regulation of mitotic recombination 5 Homo sapiens Any process that modulates the frequency, rate or extent of DNA recombination during mitosis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000019 PAGER curation team PAGER-contact@googlegroups.com 53.7883959044369 2 13-AUG-20 GOA A 21894
TAX013217 GO:0000023 biological_process maltose metabolic process 3 Homo sapiens The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000023 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX013218 GO:0000026 molecular_function alpha-1,2-mannosyltransferase activity 3 Homo sapiens Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000026 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013219 GO:0000027 biological_process ribosomal large subunit assembly 29 Homo sapiens The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000027 PAGER curation team PAGER-contact@googlegroups.com 3291.59968009737 2 13-AUG-20 GOA A 21894
TAX013220 GO:0000028 biological_process ribosomal small subunit assembly 18 Homo sapiens The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000028 PAGER curation team PAGER-contact@googlegroups.com 2478.77079703716 2 13-AUG-20 GOA A 21894
TAX013221 GO:0000030 molecular_function mannosyltransferase activity 25 Homo sapiens Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000030 PAGER curation team PAGER-contact@googlegroups.com 226.118357610586 2 13-AUG-20 GOA A 21894
TAX013222 GO:0000032 biological_process cell wall mannoprotein biosynthetic process 1 Homo sapiens The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000032 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013223 GO:0000033 molecular_function alpha-1,3-mannosyltransferase activity 3 Homo sapiens Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000033 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX013224 GO:0000035 molecular_function acyl binding 3 Homo sapiens Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000035 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013225 GO:0000036 molecular_function acyl carrier activity 2 Homo sapiens Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000036 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013226 GO:0000038 biological_process very long-chain fatty acid metabolic process 29 Homo sapiens The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000038 PAGER curation team PAGER-contact@googlegroups.com 119.020086328441 2 13-AUG-20 GOA A 21894
WAG001279 Paxillin-independent events mediated by a4b1 and a4b7 23 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 3570.03798668342 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX013227 GO:0000041 biological_process transition metal ion transport 109 Homo sapiens The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000041 PAGER curation team PAGER-contact@googlegroups.com 732.832807426716 2 13-AUG-20 GOA A 21894
TAX013228 GO:0000045 biological_process autophagosome assembly 47 Homo sapiens The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000045 PAGER curation team PAGER-contact@googlegroups.com 873.223653821378 2 13-AUG-20 GOA A 21894
TAX013229 GO:0000048 molecular_function peptidyltransferase activity 2 Homo sapiens Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000048 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013230 GO:0000049 molecular_function tRNA binding 48 Homo sapiens Interacting selectively and non-covalently with transfer RNA. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000049 PAGER curation team PAGER-contact@googlegroups.com 446.1767606308 2 13-AUG-20 GOA A 21894
TAX013231 GO:0000050 biological_process urea cycle 11 Homo sapiens The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000050 PAGER curation team PAGER-contact@googlegroups.com 1223.881590108 2 13-AUG-20 GOA A 21894
TAX013232 GO:0000052 biological_process citrulline metabolic process 7 Homo sapiens The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000052 PAGER curation team PAGER-contact@googlegroups.com 382.113883299799 2 13-AUG-20 GOA A 21894
TAX013233 GO:0000053 biological_process argininosuccinate metabolic process 1 Homo sapiens The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000053 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013234 GO:0000054 biological_process ribosomal subunit export from nucleus 12 Homo sapiens The directed movement of a ribosomal subunit from the nucleus into the cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000054 PAGER curation team PAGER-contact@googlegroups.com 430.27915819784 2 13-AUG-20 GOA A 21894
TAX013235 GO:0000055 biological_process ribosomal large subunit export from nucleus 8 Homo sapiens The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000055 PAGER curation team PAGER-contact@googlegroups.com 288.305452084897 2 13-AUG-20 GOA A 21894
TAX013236 GO:0000056 biological_process ribosomal small subunit export from nucleus 5 Homo sapiens The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000056 PAGER curation team PAGER-contact@googlegroups.com 194.824428125264 2 13-AUG-20 GOA A 21894
TAX013238 GO:0000062 molecular_function fatty-acyl-CoA binding 17 Homo sapiens Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000062 PAGER curation team PAGER-contact@googlegroups.com 32.3041474654378 2 13-AUG-20 GOA A 21894
TAX013239 GO:0000064 molecular_function L-ornithine transmembrane transporter activity 5 Homo sapiens Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000064 PAGER curation team PAGER-contact@googlegroups.com 23.9931740614334 2 13-AUG-20 GOA A 21894
TAX013240 GO:0000070 biological_process mitotic sister chromatid segregation 25 Homo sapiens The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000070 PAGER curation team PAGER-contact@googlegroups.com 2258.39207450593 2 13-AUG-20 GOA A 21894
TAX013241 GO:0000075 biological_process cell cycle checkpoint 126 Homo sapiens A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000075 PAGER curation team PAGER-contact@googlegroups.com 1504.55408614549 2 13-AUG-20 GOA A 21894
TAX013242 GO:0000076 biological_process DNA replication checkpoint 15 Homo sapiens A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000076 PAGER curation team PAGER-contact@googlegroups.com 977.071286716186 2 13-AUG-20 GOA A 21894
WAG001210 Jak-STAT signaling pathway 141 Homo sapiens The Janus kise/sigl transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of sigls for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal sigling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cogte receptor, STATs are activated by members of the JAK family of tyrosine kises. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kises, PI3 kise etc. These molecules process downstream sigls via the Ras-Raf-MAP kise and PI3 kise pathways which results in the activation of additiol transcription factors. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04630 PAGER curation team PAGER-contact@googlegroups.com 6007.59717238831 1.0 13-AUG-20 KEGG P 199
WAG001211 Benzoate degradation via CoA ligation 11 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00632 PAGER curation team PAGER-contact@googlegroups.com 186.9127058039 1.0 13-AUG-20 KEGG P 199
TAX013243 GO:0000077 biological_process DNA damage checkpoint 68 Homo sapiens A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000077 PAGER curation team PAGER-contact@googlegroups.com 706.948964392754 2 13-AUG-20 GOA A 21894
TAX013244 GO:0000079 biological_process regulation of cyclin-dependent protein serine/threonine kinase activity 86 Homo sapiens Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000079 PAGER curation team PAGER-contact@googlegroups.com 885.143625299988 2 13-AUG-20 GOA A 21894
TAX013245 GO:0000082 biological_process G1/S transition of mitotic cell cycle 98 Homo sapiens The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000082 PAGER curation team PAGER-contact@googlegroups.com 3539.90455369585 2 13-AUG-20 GOA A 21894
TAX013246 GO:0000083 biological_process regulation of transcription involved in G1/S transition of mitotic cell cycle 28 Homo sapiens Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000083 PAGER curation team PAGER-contact@googlegroups.com 2598.63880239894 2 13-AUG-20 GOA A 21894
WAG001280 S1P3 pathway 17 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 1882.59227679342 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001282 Ephrin A reverse signaling 3 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=ephrinb_ephbpathway&pathway_me=EphrinB-EPHB pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX013248 GO:0000095 molecular_function S-adenosyl-L-methionine transmembrane transporter activity 1 Homo sapiens Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000095 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013249 GO:0000096 biological_process sulfur amino acid metabolic process 39 Homo sapiens The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000096 PAGER curation team PAGER-contact@googlegroups.com 491.973763975074 2 13-AUG-20 GOA A 21894
TAX013250 GO:0000097 biological_process sulfur amino acid biosynthetic process 17 Homo sapiens The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000097 PAGER curation team PAGER-contact@googlegroups.com 531.690289872281 2 13-AUG-20 GOA A 21894
TAX013251 GO:0000098 biological_process sulfur amino acid catabolic process 14 Homo sapiens The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000098 PAGER curation team PAGER-contact@googlegroups.com 137.196761700149 2 13-AUG-20 GOA A 21894
TAX013252 GO:0000099 molecular_function sulfur amino acid transmembrane transporter activity 7 Homo sapiens Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000099 PAGER curation team PAGER-contact@googlegroups.com 124.641022606226 2 13-AUG-20 GOA A 21894
TAX013253 GO:0000101 biological_process sulfur amino acid transport 6 Homo sapiens The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000101 PAGER curation team PAGER-contact@googlegroups.com 63.3983286908078 2 13-AUG-20 GOA A 21894
TAX013254 GO:0000103 biological_process sulfate assimilation 3 Homo sapiens The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000103 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX013255 GO:0000104 molecular_function succinate dehydrogenase activity 5 Homo sapiens Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000104 PAGER curation team PAGER-contact@googlegroups.com 351.314327115163 2 13-AUG-20 GOA A 21894
TAX013257 GO:0000109 cellular_component nucleotide-excision repair complex 10 Homo sapiens Any complex formed of proteins that act in nucleotide-excision repair. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000109 PAGER curation team PAGER-contact@googlegroups.com 1952.49587517265 2 13-AUG-20 GOA A 21894
TAX013258 GO:0000110 cellular_component nucleotide-excision repair factor 1 complex 3 Homo sapiens One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000110 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX013259 GO:0000111 cellular_component nucleotide-excision repair factor 2 complex 1 Homo sapiens One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000111 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013260 GO:0000117 biological_process regulation of transcription involved in G2/M transition of mitotic cell cycle 2 Homo sapiens Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000117 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013261 GO:0000118 cellular_component histone deacetylase complex 61 Homo sapiens A protein complex that possesses histone deacetylase activity. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000118 PAGER curation team PAGER-contact@googlegroups.com 5119.96882605228 2 13-AUG-20 GOA A 21894
TAX013262 GO:0000120 cellular_component RNA polymerase I transcription factor complex 4 Homo sapiens A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000120 PAGER curation team PAGER-contact@googlegroups.com 882.508700274157 2 13-AUG-20 GOA A 21894
TAX013263 GO:0000121 molecular_function glycerol-1-phosphatase activity 1 Homo sapiens Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000121 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013264 GO:0000122 biological_process negative regulation of transcription by RNA polymerase II 781 Homo sapiens Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000122 PAGER curation team PAGER-contact@googlegroups.com 577.275886402433 2 13-AUG-20 GOA A 21894
TAX013265 GO:0000123 cellular_component histone acetyltransferase complex 79 Homo sapiens A protein complex that possesses histone acetyltransferase activity. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000123 PAGER curation team PAGER-contact@googlegroups.com 1889.107198376 2 13-AUG-20 GOA A 21894
TAX013266 GO:0000124 cellular_component SAGA complex 15 Homo sapiens A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000124 PAGER curation team PAGER-contact@googlegroups.com 2006.52426803833 2 13-AUG-20 GOA A 21894
TAX013267 GO:0000125 cellular_component PCAF complex 5 Homo sapiens A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000125 PAGER curation team PAGER-contact@googlegroups.com 1216.80585240307 2 13-AUG-20 GOA A 21894
TAX013268 GO:0000126 cellular_component transcription factor TFIIIB complex 3 Homo sapiens A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000126 PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 2 13-AUG-20 GOA A 21894
TAX013269 GO:0000127 cellular_component transcription factor TFIIIC complex 6 Homo sapiens A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000127 PAGER curation team PAGER-contact@googlegroups.com 1744.99138319124 2 13-AUG-20 GOA A 21894
TAX013270 GO:0000132 biological_process establishment of mitotic spindle orientation 22 Homo sapiens A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000132 PAGER curation team PAGER-contact@googlegroups.com 351.219586224802 2 13-AUG-20 GOA A 21894
TAX013271 GO:0000137 cellular_component Golgi cis cisterna 8 Homo sapiens The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000137 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013361 GO:0000306 cellular_component extrinsic component of vacuolar membrane 3 Homo sapiens The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000306 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013362 GO:0000307 cellular_component cyclin-dependent protein kinase holoenzyme complex 40 Homo sapiens Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000307 PAGER curation team PAGER-contact@googlegroups.com 2838.0580680423 2 13-AUG-20 GOA A 21894
TAX013363 GO:0000308 cellular_component cytoplasmic cyclin-dependent protein kinase holoenzyme complex 2 Homo sapiens Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000308 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013364 GO:0000309 molecular_function nicotinamide-nucleotide adenylyltransferase activity 3 Homo sapiens Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000309 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX013365 GO:0000313 cellular_component organellar ribosome 25 Homo sapiens A ribosome contained within a subcellular membrane-bounded organelle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000313 PAGER curation team PAGER-contact@googlegroups.com 740.337350640949 2 13-AUG-20 GOA A 21894
TAX013366 GO:0000314 cellular_component organellar small ribosomal subunit 28 Homo sapiens The smaller of the two subunits of an organellar ribosome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000314 PAGER curation team PAGER-contact@googlegroups.com 1667.0590937838 2 13-AUG-20 GOA A 21894
TAX013367 GO:0000315 cellular_component organellar large ribosomal subunit 56 Homo sapiens The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000315 PAGER curation team PAGER-contact@googlegroups.com 2478.06045381702 2 13-AUG-20 GOA A 21894
TAX013368 GO:0000320 biological_process re-entry into mitotic cell cycle 2 Homo sapiens The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000320 PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 2 13-AUG-20 GOA A 21894
TAX013370 GO:0000323 cellular_component lytic vacuole 276 Homo sapiens A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000323 PAGER curation team PAGER-contact@googlegroups.com 87.0141938826254 2 13-AUG-20 GOA A 21894
TAX013371 GO:0000333 cellular_component telomerase catalytic core complex 1 Homo sapiens The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000333 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013372 GO:0000334 molecular_function 3-hydroxyanthranilate 3,4-dioxygenase activity 1 Homo sapiens Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000334 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
WAG001620 Complement and coagulation cascades 65 Homo sapiens The complement system is a proteolytic cascade in blood plasma and a mediator of inte immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the altertive pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culmiting the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of inte immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04610 PAGER curation team PAGER-contact@googlegroups.com 3383.86407463898 1.0 13-AUG-20 KEGG P 199
WAG001623 alpha-Linolenic acid metabolism 14 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00592 PAGER curation team PAGER-contact@googlegroups.com 3322.38162344983 1.0 13-AUG-20 KEGG P 199
WAG001624 Sphingolipid metabolism 40 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00600 PAGER curation team PAGER-contact@googlegroups.com 1869.17512017819 1.0 13-AUG-20 KEGG P 199
WAG001625 Basal transcription factors 33 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03022 PAGER curation team PAGER-contact@googlegroups.com 6389.53494113145 1.0 13-AUG-20 KEGG P 199
WAG001626 C21-Steroid hormone metabolism 11 Homo sapiens Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctiol enzyme complex to the gestagen hormone, progesterone [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00140 PAGER curation team PAGER-contact@googlegroups.com 1500.28132245113 1.0 13-AUG-20 KEGG P 199
WAG001629 D-Glutamine and D-glutamate metabolism 17 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00471 PAGER curation team PAGER-contact@googlegroups.com 2718.61827074685 1.0 13-AUG-20 KEGG P 199
WAG001630 N-Glycan biosynthesis 46 Homo sapiens N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, Glcc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-Glcc and the lipid-like precursor P-Dol (dolichol phosphate) to generate Glcc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00510 PAGER curation team PAGER-contact@googlegroups.com 552.209489482351 1.0 13-AUG-20 KEGG P 199
TAX013373 GO:0000338 biological_process protein deneddylation 10 Homo sapiens The removal of a ubiquitin-like protein of the NEDD8 type from a protein. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000338 PAGER curation team PAGER-contact@googlegroups.com 2866.94394154317 2 13-AUG-20 GOA A 21894
TAX013374 GO:0000339 molecular_function RNA cap binding 17 Homo sapiens Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000339 PAGER curation team PAGER-contact@googlegroups.com 357.447369777023 2 13-AUG-20 GOA A 21894
TAX013375 GO:0000340 molecular_function RNA 7-methylguanosine cap binding 8 Homo sapiens Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000340 PAGER curation team PAGER-contact@googlegroups.com 365.232289768464 2 13-AUG-20 GOA A 21894
TAX013376 GO:0000346 cellular_component transcription export complex 13 Homo sapiens The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000346 PAGER curation team PAGER-contact@googlegroups.com 937.011038309865 2 13-AUG-20 GOA A 21894
WAG000651 p38 mapk signaling pathway 24 Homo sapiens p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress sigls are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kise (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kise. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1. https://cgap.nci.nih.gov/Pathways/BioCarta/h_p38mapkPathway PAGER curation team PAGER-contact@googlegroups.com 841.647711969403 1.0 13-AUG-20 BioCarta P 252
WAG000652 role of mef2d in t-cell apoptosis 21 Homo sapiens Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell Calcium Induced Apoptosis. Several factors regulate Mef2 transcription factors, including Map kises and histone deacetylase (HDAC) enzymes. https://cgap.nci.nih.gov/Pathways/BioCarta/h_mef2dPathway PAGER curation team PAGER-contact@googlegroups.com 1683.76093064546 1.0 13-AUG-20 BioCarta P 252
WAG000653 oxidative stress induced gene expression via nrf2 7 Homo sapiens Reactive oxygen species (ROS) can damage biological macromolecules and are detrimental to cellular health. Electrophilic compounds, xenobiotics and antioxidants are sources of reactive oxygen species, creating oxidative stress that can harm cells. Enzymes are involved in the Phase II detoxification of xenobiotics to reduce cellular stress include glutathione transferases, quinone reductase, epoxide hydrolase, heme oxygese, UDP-glucuronosyl transferases, and gamma-glutamylcysteine synthetase. Expression of these genes protects cells from oxidative damage and can prevent mutagenesis and cancer. Transcription of these enzymes is coorditely regulated through antioxidant response elements (AREs). Nrf2 (NF-E2-related factor 2) and Nrf1 are transcription factors that bind to AREs and activate these genes. Ictive Nrf2 is retained in the cytosol by association a complex with the cytoskeletal protein Keap1. Cytosolic Nrf2 is phosphorylated and translocates into the nucleus in response to protein kise C activation and Map kise pathways. In the nucleus, Nrf2 activate genes through AREs by interacting with transcription factors in the bZIP family, including CREB, ATF4 and fos or jun. Nrf2 activation of genes is opposed by small maf proteins, including MafG and MafK, maintaining a counterbalance to Nrf2 and balancing the oxidation level of the intracellular environment. https://cgap.nci.nih.gov/Pathways/BioCarta/h_arenrf2Pathway PAGER curation team PAGER-contact@googlegroups.com 480.109622440525 1.0 13-AUG-20 BioCarta P 252
WAG000654 rna polymerase iii transcription 8 Homo sapiens Unlike the R polymerase II that transcribes a large variety of genes that encode proteins, R polymerase III transcribes only a limited number of genes (i.e., 5S rR. tR. 7SL R, U6 snR and a few other small stable Rs); however, the transcriptiol activities of R pol III along with pol I account for 80% of total R synthesis. The A and B block sequences found in most pol III promoters is recognized by a multisubunit complex, TFIIIC. The binding of TFIIIC recruits TFIIIB, a complex of polypeptides (in human, TATA-binding protein (TBP), TFIIB-related factor (BRF), and one or more unidentified protein). Once TFIIIB is brought to the general location by TFIIIC and optimally positioned by TBP, the transcription initiates about 30bp downstream. The transcription process requires the melting of dsD and participation of TFIIIB. Unlike pol I and II, pol III termition occurs efficiently at four or more T residues without other protein factors. La protein can stimulate the release of R and pol III transcription; however, deletion of La has no apparent effect on pol III activity. https://cgap.nci.nih.gov/Pathways/BioCarta/h_Rpol3Pathway PAGER curation team PAGER-contact@googlegroups.com 850.925708811234 1.0 13-AUG-20 BioCarta P 252
WAG001006 tpo signaling pathway 20 Homo sapiens Thrombopoietin (TPO) binds to its receptor inducing aggregation and activation. TPO sigls its growth regulating effects to the cell through several major pathways including MAPK (ERK and JNK), Protein Kise C, and JAK/Stat. https://cgap.nci.nih.gov/Pathways/BioCarta/h_TPOPathway PAGER curation team PAGER-contact@googlegroups.com 3963.86362959057 1.0 13-AUG-20 BioCarta P 252
WAG001007 trefoil factors initiate mucosal healing 30 Homo sapiens Maintaining the integrity of the gastrointestil tract despite the continual presence of microbial flora and injurious agents is essential. Epithelial repair requires restitution and regeneration. During restitution, epithelial cells spread and migrate across the basement membrane to re-establish surface-cell continuity, a process that is independent of cell proliferation. Epithelial continuity depends on a family of small abundant secreted proteins, the trefoil factors (TFFs). https://cgap.nci.nih.gov/Pathways/BioCarta/h_tffPathway PAGER curation team PAGER-contact@googlegroups.com 2920.6542159429 1.0 13-AUG-20 BioCarta P 252
WAG001020 erk and pi-3 kinase are necessary for collagen binding in corneal epithelia 26 Homo sapiens Activation of the MAPK kise pathway has been identified as a mechanism that integrins use to regulate gene expression leading to cell shape changes during cell spreading or migration Epithelial cells respond to extracellular matrix (ECM) cause integrin-mediated FAK phosphorylation that in turn phosphorylates the surrounding proteins (paxillin, Fyn/shc, and src) and leads to sigl amplification. FAK also binds PI-3 kise and is upstream of the MAP kise pathway. When MAPkise or PI-3 kise was inhibited, actin reorganization was blocked. Src phosphorylates p190RhoGAP, ictivating its GAP function that may allow RhoGTP to stay active longer, promoting further sigl amplification. Activated RhoGTP binds to downstream kises such as Rho-associated coiled coil-containing protein kise (p160ROCK) and p140 diaphanous (p140Dia) to increase actin polymerization and contraction. Actin reorganization assists integrin clustering, allowing more ECM binding that increase FAK phosphorylation and other sigl transduction events. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ecmPathway PAGER curation team PAGER-contact@googlegroups.com 4182.73085492656 1.0 13-AUG-20 BioCarta P 252
WAG001014 pdgf signaling pathway 24 Homo sapiens Platelet Derived Growth Factor (PDGF) plays a critical role in cellular proliferation and development. The biologically active form is a dimer formed from the A and B chains. PDGF is active to a differing degree depending on which dimer is formed (AA, AB, or BB). The PDGF Receptor (PDGFR) is also a dimer and can form from the combition of the alpha and beta chains in any order (alpha-alpha, alpha-beta, beta-beta). The PDGFR dimer is only formed after ligand binding so the alpha/beta composition of the receptor can be influenced by the form of PDGF that is present. Upon binding of ligand the PDGFR is tyrosine phosphorylated and leads to the phosphorylation of several other cellular proteins. https://cgap.nci.nih.gov/Pathways/BioCarta/h_pdgfPathway PAGER curation team PAGER-contact@googlegroups.com 4009.62830164117 1.0 13-AUG-20 BioCarta P 252
WAG000655 role of parkin in ubiquitin-proteasomal pathway 2 Homo sapiens The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examition of these neurons in diseased tissue has revealed the presence of Lewy bodies, dense aggregates that include the protein alpha-synuclein. A genetic basis for most cases of Parkinson's disease has not yet been identified, but mutations in alpha-synuclein have been associated with at least one rare form of the disease, and mutations in another protein, the parkin gene, are associated with another inherited form of Parkinson's disease. Parkin is found in Lewy bodies along with alpha-synuclein and the parkin protein is an E3 ubiquitin ligase. Parkin appears to work in conjuction with ubiquitin activating (Uba)1, an E1 protein and the ubiquitin-conjugating (Ubc) enzymes UbcH7&8. The E1 delivers ubiquitin to the E2 in a cycle that creates an increasing chain of ubiquitin. The Parkin E3 ligates this onto substrates and so tags these proteins in normal cells, targeting them for destruction in the proteosome (see Proteosome pathway). One of the proteins that parkin normally targets for destruction is a specific O-glycosylated form of alpha-synuclein. Failure of parkin-mediated degradation of alpha-synuclein may be a key factor leading to the death of dopaminergic neurons. Another substrate of parkin is a GPCR-like protein called Pael-R that accumulates in the ER of affected cells and may cause neurol cell death. The involvement of Parkin and alpha-synuclein mutations in genetic forms of Parkinson's suggest that failure of ubiquitition and protein degradation may be causative in other forms of Parkinson's. Questions remaining include the cause of the lack of effective ubiquitition in individuals lacking obvious genetic defects in this pathway and how to use this knowledge of ubiquitition and protein degradation in Parkinson's disease to identify therapeutic strategies. https://cgap.nci.nih.gov/Pathways/BioCarta/h_parkinPathway PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 1.0 13-AUG-20 BioCarta P 252
WAG000656 regulation of eif2 9 Homo sapiens Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRi and transfers the Met-tR to the 40S subunit, to form the 43S preinitiation complex. Later in the cycle, prior to elongation, the bound GTP is hydrolyzed , releasing eIF-2-GDP. For eIF-2 to promote another round of initiation, GDP must be exchanged for GTP, a reaction catalyzed by eIF-2B. Kises activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), and hemin deficiency (HRI) can phosphorylate the a subunit of eIF-2. This phosphorylation stabilizes the eIF-2-GDP-eIF-2B complex, inhibiting the turnover of eIF-2B. eIF-2B is also inhibited by GSK-3b phosphorylation. These events result in a shut-down of cellular protein synthesis and can lead to apoptosis. https://cgap.nci.nih.gov/Pathways/BioCarta/h_eif2Pathway PAGER curation team PAGER-contact@googlegroups.com 1102.13440218 1.0 13-AUG-20 BioCarta P 252
WAG000657 apoptotic dna-fragmentation and tissue homeostasis 8 Homo sapiens Apoptotic cell death can be triggered by many different cellular stimuli, resulting in activation of apoptotic sigling pathways including caspases (see Caspase Cascade pathway) and mitochondria (see Role of Mitochondria in Apoptotic Sigling pathway). A cellular response that is characteristic of apoptosis is fragmentation of the nuclear genome to create a nucleosomal ladder. This activity is conducted by multiple nucleases activated by apoptotic sigling pathways. One nuclease involved in apoptosis is D fragmentation factor (DFF), a caspase-activated Dse (CAD). DFF/CAD is activated through cleavage of its associated inhibitor ICAD by caspases proteases during apoptosis. DFF/CAD interacts with chromatin components such as topo II and histone H1 to condense chromatin structure and perhaps recruit CAD to chromatin. Another apoptosis activated protease is endonuclease G, EndoG. EndoG is encoded in the nuclear genome but is localized to mitochondria in normal cells. EndoG may play a role in the replication of the mitochondrial genome, as well as in apoptosis. Apoptotic sigling causes the release of EndoG from mitochondria. Mitochondria are involved in apoptotic sigling in other ways as well, through the release of cytochrome c induced by Bid to activate the caspase protease cascade. These pathways are independent since the EndoG pathway still occurs in cells lacking DFF. https://cgap.nci.nih.gov/Pathways/BioCarta/h_DfragmentPathway PAGER curation team PAGER-contact@googlegroups.com 914.348084601779 1.0 13-AUG-20 BioCarta P 252
WAG000658 nitric oxide signaling pathway 9 Homo sapiens Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsyptic density protein 95 (PSD95)-neurol nitric oxide synthase (NOS1) terry complex. The increased intracellular Ca2+ stimulates the interaction of nNOS and calmodulin (CaM) and the translocaton of nNOS from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated sigling pathways. https://cgap.nci.nih.gov/Pathways/BioCarta/h_nos1Pathway PAGER curation team PAGER-contact@googlegroups.com 1357.30149758775 1.0 13-AUG-20 BioCarta P 252
WAG000659 ahr signal transduction pathway 3 Homo sapiens The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ahreceptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and D(P)H quinone oxidoreductase. The ictive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also refered to as AIP or ARA9). https://cgap.nci.nih.gov/Pathways/BioCarta/h_acrPathway PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 BioCarta P 252
WAG001008 the co-stimulatory signal during t-cell activation 17 Homo sapiens For a T cell to be activated by a specific antigen, the T cell receptor must recognize complexes of MHCI with the antigen on the surface of an antigen-presenting cell. T cells and the T cell receptor complex do not respond to antigen in solution, but even for the specific antigen they only respond to antigen-MHC-1 complexes on the cell surface. This interaction is necessary for T cell activation, but it is not sufficient. T cell activation also requires a co-stimulatory sigl involving interaction of CD28 on the T cell with CD80 or CD86 (B7 family genes) on the antigen-presenting cell. CD28 activates a sigl transduction pathway acting through PI-3K, Lck and Grb-2/ITK to provide its co-stimulatory sigl for T cell activation. Another means to control T cell activation is by expressing factors that down-regulate T cell activation. Sigling by activated T cell receptors induces expression of CTLA-4, a receptor that opposes T cell activation. CTLA-4 has a higher affinity than CD28 for B7 proteins, termiting T cell activation. ICOS is a protein related to CD28 that is only expressed on activated T cells, and that provides another important co-stimulatory sigl. The requirement for co-stimulatory sigls provides additiol control mechanisms that prevent ippropriate and hazardous T cell activation. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ctla4Pathway PAGER curation team PAGER-contact@googlegroups.com 4493.73113948325 1.0 13-AUG-20 BioCarta P 252
WAG001009 intrinsic prothrombin activation pathway 22 Homo sapiens Blood coagulation or clotting takes place in 3 essential phases. The first phase is the activation of a prothrombin activator complex. The second phase is the activation of prothrombin. The third stage is clot formation as a result of fibrinogen cleavage by activated thrombin. (See https://cgap.nci.nih.gov/Pathways/BioCarta/h_intrinsicPathway PAGER curation team PAGER-contact@googlegroups.com 1474.69600746318 1.0 13-AUG-20 BioCarta P 252
WAG001010 roles of beta arrestin dependent recruitment of src kinases in gpcr signaling 11 Homo sapiens The binding of ?arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kises, including c-Src, Hck and c-Fgr (Src-TK), to the receptor?arrestin complex. Several sigling events have been reported to involve ?arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent ?-adrenergic receptor endocytosis by tyrosine phosphorylation of dymin, Ras-dependent activation of the ERK1/2 MAP kise cascade and stimulation of cell proliferation by ?-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation https://cgap.nci.nih.gov/Pathways/BioCarta/h_bArrestin-srcPathway PAGER curation team PAGER-contact@googlegroups.com 1368.99647029065 1.0 13-AUG-20 BioCarta P 252
WAG001011 p53 signaling pathway 13 Homo sapiens p53 is a transcription factor who's activity is regulated by phosphorylation. The function is p53 is to keep the cell from progressing through the cell cycle if there is damage to D present. It may do this in multiple ways from holding the cell at a checkpoint until repairs can be made to causing the cell to enter apoptosis if the damage cannot be repaired. The critical role of p53 is evidenced by the fact that it is mutated in a very large fraction of tumors from nearly all sources. https://cgap.nci.nih.gov/Pathways/BioCarta/h_p53Pathway PAGER curation team PAGER-contact@googlegroups.com 3656.58867151589 1.0 13-AUG-20 BioCarta P 252
WAG001012 insulin signaling pathway 10 Homo sapiens The appropriate sigling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a complex with the Insulin Receptor (IR) and b chains to form the active sigling complex. Through recruitment of adaptor molecules and the activation of RAS, the activated IR can cause transcriptiol activation. https://cgap.nci.nih.gov/Pathways/BioCarta/h_insulinPathway PAGER curation team PAGER-contact@googlegroups.com 2605.66238008138 1.0 13-AUG-20 BioCarta P 252
WAG001428 Long-term depression 62 Homo sapiens Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the syptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple sigl transduction pathways have been shown to be involved in this process. Activation of PFs termiting on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple syptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular sigls, generated from two different syptic origins, trigger a cascade of events culmiting in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC sypse. This may take place either through receptor interlization and/or through receptor desensitization. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04730 PAGER curation team PAGER-contact@googlegroups.com 2427.25089821406 1.0 13-AUG-20 KEGG P 199
TAX013306 GO:0000212 biological_process meiotic spindle organization 11 Homo sapiens A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000212 PAGER curation team PAGER-contact@googlegroups.com 43.5124309652611 2 13-AUG-20 GOA A 21894
TAX013307 GO:0000213 molecular_function tRNA-intron endonuclease activity 4 Homo sapiens Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000213 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 2 13-AUG-20 GOA A 21894
TAX013308 GO:0000214 cellular_component tRNA-intron endonuclease complex 4 Homo sapiens A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000214 PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 2 13-AUG-20 GOA A 21894
TAX013309 GO:0000215 molecular_function tRNA 2'-phosphotransferase activity 2 Homo sapiens Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000215 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013310 GO:0000217 molecular_function DNA secondary structure binding 25 Homo sapiens Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000217 PAGER curation team PAGER-contact@googlegroups.com 1310.19714817111 2 13-AUG-20 GOA A 21894
WAG001429 Porphyrin and chlorophyll metabolism 58 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00860 PAGER curation team PAGER-contact@googlegroups.com 579.730021378629 1.0 13-AUG-20 KEGG P 199
WAG001430 Regulation of actin cytoskeleton 184 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04810 PAGER curation team PAGER-contact@googlegroups.com 2313.63801521092 1.0 13-AUG-20 KEGG P 199
TAX013311 GO:0000220 cellular_component vacuolar proton-transporting V-type ATPase, V0 domain 6 Homo sapiens The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000220 PAGER curation team PAGER-contact@googlegroups.com 1744.99138319124 2 13-AUG-20 GOA A 21894
TAX013312 GO:0000221 cellular_component vacuolar proton-transporting V-type ATPase, V1 domain 3 Homo sapiens The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000221 PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 2 13-AUG-20 GOA A 21894
TAX013313 GO:0000224 molecular_function peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity 1 Homo sapiens Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000224 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013314 GO:0000225 molecular_function N-acetylglucosaminylphosphatidylinositol deacetylase activity 1 Homo sapiens Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000225 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013316 GO:0000228 cellular_component nuclear chromosome 50 Homo sapiens A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000228 PAGER curation team PAGER-contact@googlegroups.com 304.542391104001 2 13-AUG-20 GOA A 21894
TAX013317 GO:0000229 cellular_component cytoplasmic chromosome 1 Homo sapiens A chromosome found in the cytoplasm. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000229 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013318 GO:0000235 cellular_component astral microtubule 7 Homo sapiens Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000235 PAGER curation team PAGER-contact@googlegroups.com 29.3647058823529 2 13-AUG-20 GOA A 21894
TAX013319 GO:0000242 cellular_component pericentriolar material 19 Homo sapiens A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000242 PAGER curation team PAGER-contact@googlegroups.com 118.784220118289 2 13-AUG-20 GOA A 21894
TAX013320 GO:0000243 cellular_component commitment complex 8 Homo sapiens A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000243 PAGER curation team PAGER-contact@googlegroups.com 1002.48820881123 2 13-AUG-20 GOA A 21894
TAX013321 GO:0000244 biological_process spliceosomal tri-snRNP complex assembly 12 Homo sapiens The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000244 PAGER curation team PAGER-contact@googlegroups.com 500.498764026858 2 13-AUG-20 GOA A 21894
TAX013322 GO:0000245 biological_process spliceosomal complex assembly 27 Homo sapiens The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000245 PAGER curation team PAGER-contact@googlegroups.com 1990.08812703519 2 13-AUG-20 GOA A 21894
TAX013323 GO:0000246 molecular_function delta24(24-1) sterol reductase activity 1 Homo sapiens Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000246 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013324 GO:0000247 molecular_function C-8 sterol isomerase activity 2 Homo sapiens Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000247 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013325 GO:0000248 molecular_function C-5 sterol desaturase activity 2 Homo sapiens Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000248 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013326 GO:0000250 molecular_function lanosterol synthase activity 1 Homo sapiens Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000250 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013327 GO:0000252 molecular_function C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity 1 Homo sapiens Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000252 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013328 GO:0000253 molecular_function 3-keto sterol reductase activity 4 Homo sapiens Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000253 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013329 GO:0000254 molecular_function C-4 methylsterol oxidase activity 1 Homo sapiens Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000254 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013330 GO:0000255 biological_process allantoin metabolic process 5 Homo sapiens The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000255 PAGER curation team PAGER-contact@googlegroups.com 151.800928775248 2 13-AUG-20 GOA A 21894
TAX013331 GO:0000256 biological_process allantoin catabolic process 1 Homo sapiens The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000256 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013332 GO:0000257 molecular_function nitrilase activity 1 Homo sapiens Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000257 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013334 GO:0000266 biological_process mitochondrial fission 21 Homo sapiens The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000266 PAGER curation team PAGER-contact@googlegroups.com 24.581171237954 2 13-AUG-20 GOA A 21894
TAX013335 GO:0000268 molecular_function peroxisome targeting sequence binding 5 Homo sapiens Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000268 PAGER curation team PAGER-contact@googlegroups.com 188.558607956135 2 13-AUG-20 GOA A 21894
TAX013337 GO:0000271 biological_process polysaccharide biosynthetic process 37 Homo sapiens The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000271 PAGER curation team PAGER-contact@googlegroups.com 194.024091965268 2 13-AUG-20 GOA A 21894
TAX013338 GO:0000272 biological_process polysaccharide catabolic process 16 Homo sapiens The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000272 PAGER curation team PAGER-contact@googlegroups.com 282.135777977057 2 13-AUG-20 GOA A 21894
TAX013340 GO:0000275 cellular_component mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) 3 Homo sapiens The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000275 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013341 GO:0000276 cellular_component mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) 4 Homo sapiens All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000276 PAGER curation team PAGER-contact@googlegroups.com 134.847820000747 2 13-AUG-20 GOA A 21894
TAX013342 GO:0000278 biological_process mitotic cell cycle 103 Homo sapiens Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000278 PAGER curation team PAGER-contact@googlegroups.com 610.853039544736 2 13-AUG-20 GOA A 21894
TAX013343 GO:0000280 biological_process nuclear division 59 Homo sapiens The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000280 PAGER curation team PAGER-contact@googlegroups.com 61.2820055288829 2 13-AUG-20 GOA A 21894
TAX013344 GO:0000281 biological_process mitotic cytokinesis 45 Homo sapiens A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000281 PAGER curation team PAGER-contact@googlegroups.com 580.935736342756 2 13-AUG-20 GOA A 21894
TAX013345 GO:0000285 molecular_function 1-phosphatidylinositol-3-phosphate 5-kinase activity 4 Homo sapiens Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000285 PAGER curation team PAGER-contact@googlegroups.com 79.8458149779736 2 13-AUG-20 GOA A 21894
TAX013346 GO:0000287 molecular_function magnesium ion binding 201 Homo sapiens Interacting selectively and non-covalently with magnesium (Mg) ions. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000287 PAGER curation team PAGER-contact@googlegroups.com 62.8387475539715 2 13-AUG-20 GOA A 21894
TAX013347 GO:0000288 biological_process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 11 Homo sapiens A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000288 PAGER curation team PAGER-contact@googlegroups.com 79.3624300228074 2 13-AUG-20 GOA A 21894
TAX013348 GO:0000289 biological_process nuclear-transcribed mRNA poly(A) tail shortening 22 Homo sapiens Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000289 PAGER curation team PAGER-contact@googlegroups.com 920.025321343548 2 13-AUG-20 GOA A 21894
TAX013349 GO:0000290 biological_process deadenylation-dependent decapping of nuclear-transcribed mRNA 10 Homo sapiens Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000290 PAGER curation team PAGER-contact@googlegroups.com 248.06462540595 2 13-AUG-20 GOA A 21894
TAX013350 GO:0000291 biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic 35 Homo sapiens The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000291 PAGER curation team PAGER-contact@googlegroups.com 2734.18573903833 2 13-AUG-20 GOA A 21894
TAX013351 GO:0000293 molecular_function ferric-chelate reductase activity 3 Homo sapiens Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+). http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000293 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 2 13-AUG-20 GOA A 21894
TAX013353 GO:0000295 molecular_function adenine nucleotide transmembrane transporter activity 13 Homo sapiens Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000295 PAGER curation team PAGER-contact@googlegroups.com 40.0551124812734 2 13-AUG-20 GOA A 21894
TAX013354 GO:0000296 biological_process spermine transport 1 Homo sapiens The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000296 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013355 GO:0000298 molecular_function endopolyphosphatase activity 4 Homo sapiens Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000298 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
TAX013356 GO:0000301 biological_process retrograde transport, vesicle recycling within Golgi 4 Homo sapiens The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000301 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 2 13-AUG-20 GOA A 21894
WAG001433 Pancreatic cancer 65 Homo sapiens Infiltrating ductal adenocarcinoma is the most common maligncy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, ictivation of the p16 gene at an intermediate stage, and the ictivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventiolly regarded as upstream activators of RAS proteins, they can also act as RAS sigl transducers via RAS-induced autocrine activation of the EGFR family ligands. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Ictivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta siglling pathway. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05212 PAGER curation team PAGER-contact@googlegroups.com 3782.08942100166 1.0 13-AUG-20 KEGG P 199
WAG001434 Valine, leucine and isoleucine biosynthesis 19 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00290 PAGER curation team PAGER-contact@googlegroups.com 2062.30698487303 1.0 13-AUG-20 KEGG P 199
WAG001435 Lysine degradation 38 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00310 PAGER curation team PAGER-contact@googlegroups.com 775.599114139481 1.0 13-AUG-20 KEGG P 199
WAG001436 Homologous recombination 22 Homo sapiens Homologous recombition (HR) is essential for the accurate repair of D double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of D, followed by strand invasion, formation of a Holliday junction, D synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03440 PAGER curation team PAGER-contact@googlegroups.com 2494.5911310663 1.0 13-AUG-20 KEGG P 199
WAG001437 Histidine metabolism 33 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00340 PAGER curation team PAGER-contact@googlegroups.com 679.383690864514 1.0 13-AUG-20 KEGG P 199
WAG001438 Nicotinate and nicotinamide metabolism 20 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00760 PAGER curation team PAGER-contact@googlegroups.com 1977.54338192907 1.0 13-AUG-20 KEGG P 199
WAG001439 Circadian rhythm 11 Homo sapiens Circadian rhythm is an interl biological clock, which ebles to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of cell-autonomous transcription-translation feedback loops that drive rhythmic, 24-hour expression patterns of core clock components. The first negative feedback loop is a rhythmic transcription of period genes (PER1, PER2, and PER3) and chryptochrome genes (CRY1 and CRY2). PER and CRY proteins form a heterodimer, which acts on the CLOCK/BMAL1 heterodimer to repress its own transcription. PER and CRY proteins are phosphorylated by casein kise epsilon (CKIepsilon), which leads to degradation and restarting of the cycle. The second loop is a positive feedback loop driven by the CLOCK/BMAL1 heterodimer, which initiates transcription of target genes containing E-box cis-regulatory enhancer sequences. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04710 PAGER curation team PAGER-contact@googlegroups.com 3477.83497171634 1.0 13-AUG-20 KEGG P 199
WAG001618 Reductive carboxylate cycle (CO2 fixation) 17 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00720 PAGER curation team PAGER-contact@googlegroups.com 1247.54765620571 1.0 13-AUG-20 KEGG P 199
WAG001619 Pentose phosphate pathway 41 Homo sapiens The pentose phosphate pathway is a process of glucose turnover that produces DPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and DPH is generated [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00030 PAGER curation team PAGER-contact@googlegroups.com 4696.91796484573 1.0 13-AUG-20 KEGG P 199
TAX013357 GO:0000302 biological_process response to reactive oxygen species 173 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000302 PAGER curation team PAGER-contact@googlegroups.com 416.868872173855 2 13-AUG-20 GOA A 21894
TAX013358 GO:0000303 biological_process response to superoxide 6 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000303 PAGER curation team PAGER-contact@googlegroups.com 48.1647058823529 2 13-AUG-20 GOA A 21894
WAG001476 Hedgehog signaling events mediated by Gli proteins 35 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 1548.45908416515 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001477 Canonical Wnt signaling pathway 29 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=nfkappabcanonicalpathway&pathway_me=Canonical NF-kappaB pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2208.70609964637 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001478 Signaling events mediated by Stem cell factor receptor (c-Kit) 52 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 4187.90457046353 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001479 Integrins in angiogenesis 45 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=avb3_integrin_pathway&pathway_me=Integrins in angiogenesis&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3404.96050852082 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001480 Syndecan-1-mediated signaling events 11 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 213.49593802424 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001481 Circadian rhythm pathway 12 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=circadianpathway&pathway_me=Circadian rhythm pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 900.113824743291 1.0 13-AUG-20 NCI-Nature Curated P 132
TAX013359 GO:0000304 biological_process response to singlet oxygen 1 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000304 PAGER curation team PAGER-contact@googlegroups.com 0.0 2 13-AUG-20 GOA A 21894
TAX013360 GO:0000305 biological_process response to oxygen radical 9 Homo sapiens Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. http://amigo.geneontology.org/amigo/search/ontology?q=GO:0000305 PAGER curation team PAGER-contact@googlegroups.com 60.4815409309791 2 13-AUG-20 GOA A 21894
WAG001013 cyclin e destruction pathway 9 Homo sapiens Cyclins are proteins that associate with cyclin-dependent protein kises to regulate their activity and the progression of the cell cycle through specific checkpoints. Disruption of cyclin action can lead to either cell cycle arrest, or to uncontrolled cell cycle proliferation. The cyclical increase and decrease in cyclin levels is a key to cell cycle regulation. When cyclin E is abundant it interacts with the cell cycle checkpoint kise cdk2 to activate cdk2 and allow progression of the cell cycle from G1 to S phase. One of the key targets of activated cdk2 complexed with cyclin E is the tumor suppressor Rb. When dephosphorylated in G1, Rb complexes with and blocks transcriptiol activation by E2F transcription factors. When Rb is phosphorylated by cdk2/Cyclin E, it dissociates from E2f, allowing E2F to activate the transcription of genes required for S phase. One of the genes activated by E2F is cyclin E itself, leading to a positive feedback cycle as cyclin E accumulates. The decision by the cell to either remain in G1 or progress into S phase is the result in part of the balance between cyclin E production and proteolytic degradation in the proteosome. Cyclin E is targeted for destruction by the proteosome through ubiquitition when associated with a complex of proteins called the SCF or F box complex. Proteins included this complex include an F box protein that targets specific substrates such as Cyclin E for degradation. In the case of cyclin E the F box protein Fbw7, also called hCdc4, associates with phosphorylated free cyclin E to recruit it into the SCF complex for degradation. SCFFbw7 is a ubiquitin ligase recruited into the complex that specifically targets cyclin E. Cul3, skp1, and Rbx1 also are part of the complex that degrades cyclin E. There may be redundancy for some components of the complex since cul1 deletion also disrupts cyclin E degradation, and multiple F box proteins may contribute to cyclin E degradation. The interaction of multiple different factors in cyclin E accumulation integrates different sigling pathways with cell cycle regulation and may play a role in the unregulated cell cycle progression of cancer. https://cgap.nci.nih.gov/Pathways/BioCarta/h_fbw7Pathway PAGER curation team PAGER-contact@googlegroups.com 1951.46439011656 1.0 13-AUG-20 BioCarta P 252
WAG000409 eukaryotic protein translation 14 Homo sapiens The scanning translation initiation model suggests that 40S ribosomal subunit preloaded with factors bind to the 5?end of the mR near the cap. The 48S subunit moves along the mR until it finds the initiation triplet and in complex with tR and 60S subunit formed the first peptide bond. Translation control is mostly regulated at the protein initiation step through translation initiation factors such as eIF2 or eIF4. https://cgap.nci.nih.gov/Pathways/BioCarta/h_eifPathway PAGER curation team PAGER-contact@googlegroups.com 4382.28970347366 1.0 13-AUG-20 BioCarta P 252
WAG000410 role of erbb2 in signal transduction and oncology 20 Homo sapiens Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the molecular weight of 185 KDa. Unlike other members of EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functiol heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as well as gp130 subunits of IL-6 receptor. In at least some cell types, the association between gp130 and HRBB2 is essential for HRBB2-ERBB3 phosphorylation and subsequent MAP kise sigling. Although ERBB1 can form homodimers, the sigling for ERBB1 is usually transient and the receptor undergoes interlization after ligand binding and activation. EGFR-HER2 complex increases the sigling capacity of EGFR by increasing the ligand affinity as well as the recycling of the heterodimer. Of all the ERBB heterodimers, ERBB2-ERBB3 heterodimers perhaps elicit the strongest sigl. Removing ERBB3 from the cell has a drastic effect on ERBB2 mediated sigling and downstream effectors. https://cgap.nci.nih.gov/Pathways/BioCarta/h_her2Pathway PAGER curation team PAGER-contact@googlegroups.com 4738.72110546284 1.0 13-AUG-20 BioCarta P 252
WAG000411 ifn alpha signaling pathway 9 Homo sapiens Interferon alpha plays a role in viral infections. Sigling takes place through an IFN Recpetor complex consisting of two alpha chains (Type I receptor) complexed with Jak1 and Tyk2. These kises phosphorylate Stat1 and Stat2 respectively. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ifPathway PAGER curation team PAGER-contact@googlegroups.com 1384.67905667487 1.0 13-AUG-20 BioCarta P 252
WAG001212 Calcium signaling pathway 153 Homo sapiens Ca2+ that enters the cell from the outside is a principal source of sigl Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this exterl source of sigl Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04020 PAGER curation team PAGER-contact@googlegroups.com 2431.74323585231 1.0 13-AUG-20 KEGG P 199
WAG001213 Systemic lupus erythematosus 39 Homo sapiens Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as D, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the rel glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the aphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05322 PAGER curation team PAGER-contact@googlegroups.com 467.430152527576 1.0 13-AUG-20 KEGG P 199
WAG001243 pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase 12 Homo sapiens The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation and possibly other processes. Phosphorylation by myosin light chain kise (MLCK) increases myosin activity and dephosphorylation by myosin phosphatase decreases myosin activity. CPI, a factor that binds to and inhibits myosin phosphatase, is a target of phosphorylation by PKC and PKN. The inhibitory activity of CPI is regulated by its own phosphorylation state; when CPI is phosphorylated, its inhibitory activity is increased. The activation of sigl transduction cascades such as GPCR pathways can lead to activation of PKC, phosphorylation of CPI, inhibition of myosin phosphatase, increased myosin phosphorylation and increased smooth muscle contraction or platelet release. The action of histamine in vasoconstriction, for example, may be mediated by activation of PKC through the histamine receptor, resulting in phosphorylation of CPI-17, increased inhibition of myosin phosphatase, and increased smooth muscle contraction. https://cgap.nci.nih.gov/Pathways/BioCarta/h_myosinPathway PAGER curation team PAGER-contact@googlegroups.com 598.485518993745 1.0 13-AUG-20 BioCarta P 252
WAG001258 regulation of splicing through sam68 9 Homo sapiens While transcriptiol regulation is often viewed as the most prevalent way extracellular sigls to regulate gene expression, post-transcriptiol regulation of splicing, R stability, and translation are also regulated by extracellular sigls. Sam68, a member of a family of R-binding proteins called STAR proteins, mediates altertive splicing in response to extracellular sigls, such as altered splicing of CD44 in response to phorbol ester treatment of T cells. R binding and activity of SAM68 is regulated by upstream sigls through phosphorylation and modulating of its interaction with other proteins, itself and with R. Phorbol ester treatment of T cells stimulates the ras/ Map kise pathway, activating Erk and phosphorylation of Sam68, inducing altertive splicing of CD44 and perhaps other cellular R targets. Sam68 is localized in the nucleus to a specific substructure called the Sam68/SLM Nuclear Bodies, colocalizing with splicing factors and helping to link perhaps sigl transduction with R processing. Sam68 has been suggested to play a role in a variety of pathways, including insulin sigling and HIV gene expression, substituting for the activity of viral Rev protein, and to be regulated by arginine methylation as well as phosphorylation. In addition to the role of Sam68 regulating posttranscriptiol gene expression, Sam68 also interacts with transcription factors such as CBP and appears to regulate gene expression. https://cgap.nci.nih.gov/Pathways/BioCarta/h_sam68Pathway PAGER curation team PAGER-contact@googlegroups.com 1300.66656090186 1.0 13-AUG-20 BioCarta P 252
WAG001260 ifn gamma signaling pathway 5 Homo sapiens Interferon gamma is secreted from CD4+ Th1 cells, CD8 cells, gamma/delta T cells and activated NK cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition it plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets. Sigling takes place through a IFN Recpetor complex consisting of two alpha chains (Type I receptor) and two beta chains (Type 2 receptor). Upon phosphorylation by Jak1, Stat1(alpha) transduces the sigl into transcriptiol events. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ifngPathway PAGER curation team PAGER-contact@googlegroups.com 1216.80585240307 1.0 13-AUG-20 BioCarta P 252
WAG001247 stat3 signaling pathway 4 Homo sapiens STATs, Sigl Transducers and Activators of Transcription, are transcription factors that are phosphorylated by JAK kises in response to cytokine activation to then dimerize and move into the nucleus to activate transcription of cytokine-responsive genes. There are at least 3 JAK kises and at least six STATs, with different cytokines inducing different patterns of JAK and STAT activation. Cytokines that activate STAT3 include growth hormone, IL-6 family cytokines, and G-CSF. STAT3, as well as STAT5, induces progression through the cell cycle, prevents apoptosis and may be associated with cancer development in some cases. STAT3 plays an important role in normal development, particularly hematopoiesis. The importance of STAT3 is underscored by the failure of mice lacking STAT3 to survive embryogenesis. Crosstalk from pathways other than JAK kises also leads to phosphorylation and activation of STAT3 as indicated by a role of mTOR (mammalian target of rapamycin, or p70 S6 kise) and mitogen-activated protein kise (MAP kise) pathways in STAT3 activation and sigling. https://cgap.nci.nih.gov/Pathways/BioCarta/h_stat3Pathway PAGER curation team PAGER-contact@googlegroups.com 188.558607956135 1.0 13-AUG-20 BioCarta P 252
WAG001248 inhibition of matrix metalloproteinases 8 Homo sapiens Cellular transformation is accompanied by many cellular changes, including uncontrolled proliferation, loss of the differentiated cell morphology, and invasion of the extracellular matrix. Degradation of the extracellular matrix is a key component of tumor cell invasion into surrounding tissues. Matrix metalloproteises (MMPs) are a class of proteases secreted by tumor cells, degrading the proteins of the extracellular matrix and allowing metastasis. Drug inhibitors of MMPs are one strategy to control cancer and block metastasis. In searching for genes that reverse the rounded morphology of transformed cells in culture, RECK was identified (reversion-inducing, cysteine-rich protein with Kazal motifs). https://cgap.nci.nih.gov/Pathways/BioCarta/h_reckPathway PAGER curation team PAGER-contact@googlegroups.com 2127.10953411405 1.0 13-AUG-20 BioCarta P 252
GEX001299 personality disorders 9 Homo sapiens personality disorders associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 813.302401410653 N 1.0 13-AUG-20 GAD G 1671
GEX000856 human renal transplantation 3 Homo sapiens human renal transplantation associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000419 cholesterol, ldl; cholesterol, total 2 Homo sapiens cholesterol, ldl; cholesterol, total associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000446 citalopram/adverse effects* 4 Homo sapiens citalopram/adverse effects* associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 449.593691000629 N 1.0 13-AUG-20 GAD G 1671
GEX000961 kidney diseases 33 Homo sapiens kidney diseases associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.32347291586631 N 1.0 13-AUG-20 GAD G 1671
GEX000027 adiponectin 58 Homo sapiens adiponectin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 5.85690488755621 N 1.0 13-AUG-20 GAD G 1671
GEX001464 schizotypal traits 2 Homo sapiens schizotypal traits associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
WAG001259 g-protein signaling through tubby proteins 3 Homo sapiens The tubby gene product is expressed in the brain and has been implicated by mouse genetics in obesity and other disorders such as blindness. Structural alysis predicted that this gene acts as a transcription factor, binding to D to regulate gene expression. More recently, it was reported that tubby binds to phosphoinositides in the plasma membrane, helping to localize this factor in the membrane region in the absence of pathway activation. Tubby also interacts with Galpha-q g-protein subunits, localizing tubby to regions of g-protein activation. Activation of phosphipase C activity and hydrolysis of membrane phosphoinositides leads to release of tubby from the plasma membrane, allowing tubby to enter the nucleus to bind D and regulate transcription. Some G-protein coupled receptors such as 5-HT2c may sigl in part through tubby in addition to calcium-mediated pathways and protein-kise sigling pathways. The identity of genes regulated by tubby and the mechanism by which tubby affects obesity remain to be explored. https://cgap.nci.nih.gov/Pathways/BioCarta/h_tubbyPathway PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 1.0 13-AUG-20 BioCarta P 252
GEX001117 methamphetamine induced psychosis 2 Homo sapiens methamphetamine induced psychosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
WAG001250 cxcr4 signaling pathway 10 Homo sapiens CXCR4 is a chemokine receptor in the GPCR gene family, and is expressed by cells in the immune system and the central nervous system. In response to binding its ligand SDF-1 (stromal cell-derived factor-1), CXCR4 triggers the migration and recruitment of immune cells. This ligand-receptor pair may also play a role in development of the nervous system. In addition to acting as a chemokine receptor, CXCR4 is a co-receptor for entry of HIV into T cells and ligands of CXCR4, including SDF-1 may help to block HIV infection. Early in the infection of an individual, HIV viruses often are tropic for the CCR5 coreceptor that provides for macrophage entry, then later in infection are tropic for CXCR4 and T cell entry. Viruses that are tropic for CXCR4 are generally syncitium forming, causing T cells to aggregate and be destroyed at a rapid rate. https://cgap.nci.nih.gov/Pathways/BioCarta/h_cxcr4Pathway PAGER curation team PAGER-contact@googlegroups.com 2794.29448654298 1.0 13-AUG-20 BioCarta P 252
WAG001251 g-secretase mediated erbb4 signaling pathway 3 Homo sapiens The HER4/erbB4 receptor tyrosine kise is a member of the EGF1 receptor family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and differentiation factors. HER4 can also bind and be activated by heparin-binding EGF growth factor, betacellulin, and epiregulin, members of the EGF family which, unlike the NRGs, are also ligands for the EGF receptor. HER4 mR is expressed in several tissues such as heart, brain, kidney, and skeletal muscle, suggesting that this receptor is involved in the development and maintence of a variety of organs and cell types. It is likely that the control of expression and function of HER4 is important in normal development as well as in disease. https://cgap.nci.nih.gov/Pathways/BioCarta/h_erbB4pathway PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 1.0 13-AUG-20 BioCarta P 252
GEX000811 hemostatic factors and hematological phenotypes 8 Homo sapiens hemostatic factors and hematological phenotypes associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 383.695607403896 N 1.0 13-AUG-20 GAD G 1671
GEX000812 hepatic gsta1/gsta2 expression 2 Homo sapiens hepatic gsta1/gsta2 expression associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000813 hepatitis 1 Homo sapiens hepatitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000815 hepatitis b liver cancer 2 Homo sapiens hepatitis b liver cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
WAG001249 regulation of eif-4e and p70s6 kinase 21 Homo sapiens eIF-4F and p70 S6 kise play critical roles in translatiol regulation. eIF-4F is a complex whose functions include the recognition of the mR 5' cap structure (eIF-4E), delivery of an R helicase to the 5' region (eIF-4A), bridging of the mR and the ribosome (eIF-4G), and circularization of the mR via interaction between eIF-4G and the poly(A) binding protein (PABP). Several stimuli, including growth factors and cytokines, regulate the eIF-4 complex and p70 S6 kise by initiating a phosphorylation cascade involving the sequential activation of PI3-K, PDK1/2, Akt/PKB, and FRAP/mTOR kise. FRAP/mTOR, together with an unidentified kise, phosphorylates 4E-BP, leading to its dissociation from and activation of eIF-4E. MNK1/2, activated by ERK and p38 MAPK, phosphorylates and activates eIF-4E. Both processes contribute to the association of eIF-4E and eIF-4G to form the active eIF-4F complex, a necessary component of the 48S initiation complex. Phosphorylation of ribosomal protein S6 by p70 S6 kise stimulates the translation of mRs with a 5' oligopyrimidine tract which typically encode components of the protein synthesis. https://cgap.nci.nih.gov/Pathways/BioCarta/h_eif4Pathway PAGER curation team PAGER-contact@googlegroups.com 1938.34336124691 1.0 13-AUG-20 BioCarta P 252
GEX000816 hepatitis b vaccines 4 Homo sapiens hepatitis b vaccines associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000817 hepatitis b, chronic 13 Homo sapiens hepatitis b, chronic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 181.076000975906 N 1.0 13-AUG-20 GAD G 1671
WAG001214 Insulin signaling pathway 120 Homo sapiens Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kise (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kise (PI3K). PI3K activates 3-phosphoinositide-dependent protein kise 1 (PDK1), which activates Akt, a serine kise. Akt in turn deactivates glycogen synthase kise 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04910 PAGER curation team PAGER-contact@googlegroups.com 1937.43621619952 1.0 13-AUG-20 KEGG P 199
WAG001215 Metabolism of xenobiotics by cytochrome P450 68 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00980 PAGER curation team PAGER-contact@googlegroups.com 11103.9168185107 1.0 13-AUG-20 KEGG P 199
WAG001216 Base excision repair 31 Homo sapiens Base excision repair (BER) is the predomint D damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as D repair initiated by lesion-specific D glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the D lesion and facilitate repair in a coordited fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintence of genome integrity by preventing the accumulation of highly toxic repair intermediates. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa03410 PAGER curation team PAGER-contact@googlegroups.com 1800.65116447935 1.0 13-AUG-20 KEGG P 199
WAG001217 Androgen and estrogen metabolism 52 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00150 PAGER curation team PAGER-contact@googlegroups.com 1862.03584520753 1.0 13-AUG-20 KEGG P 199
WAG001218 Glycan structures - biosynthesis 2 62 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa01031 PAGER curation team PAGER-contact@googlegroups.com 1609.77468540209 1.0 13-AUG-20 KEGG P 199
WAG001219 Galactose metabolism 23 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00052 PAGER curation team PAGER-contact@googlegroups.com 835.045245341073 1.0 13-AUG-20 KEGG P 199
WAG001220 Pathogenic Escherichia coli infection 46 Homo sapiens Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05130 PAGER curation team PAGER-contact@googlegroups.com 830.596168947457 1.0 13-AUG-20 KEGG P 199
WAG001221 Autoimmune thyroid disease 35 Homo sapiens The classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroiditis or primary myxedema. HT is characterized by the presence of goitre, thyroid autoantibodies against thyroid peroxidase (TPO) and thyroglobulin (Tg) in serum and varying degrees of thyroid dysfunction. During HT, self-reactive CD4+ T lymphocytes (Th) recruit B cells and CD8+ T cells (CTL) into the thyroid. Disease progression leads to the death of thyroid cells and hypothyroidism. Both autoantibodies and thyroid-specific cytotoxic T lymphocytes (CTLs) have been proposed to be responsible for autoimmune thyrocyte depletion. In GD, the TSH-R is the most important autoantigen. Antibodies directed against it mimic the effects of the hormone on thyroid cells, TSH, stimulating autonomous production of thyroxine and triiodothyronine and causing hyperthyroidism. The presence of TSH-R-blocking antibodies that bind the TSH receptor in a similar fashion to the antibodies in patients with Grave's disease but that block rather than activate the receptor explains some cases of atrophic hypothyroidism. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05320 PAGER curation team PAGER-contact@googlegroups.com 1410.5233730517 1.0 13-AUG-20 KEGG P 199
WAG001222 Glyoxylate and dicarboxylate metabolism 20 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00630 PAGER curation team PAGER-contact@googlegroups.com 659.916766482509 1.0 13-AUG-20 KEGG P 199
WAG001223 Tryptophan metabolism 47 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00380 PAGER curation team PAGER-contact@googlegroups.com 715.464996854917 1.0 13-AUG-20 KEGG P 199
WAG001224 Alkaloid biosynthesis II 20 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00960 PAGER curation team PAGER-contact@googlegroups.com 268.008004478282 1.0 13-AUG-20 KEGG P 199
WAG001225 Hedgehog signaling pathway 52 Homo sapiens The Hedgehog (Hh) family of secreted sigling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh sigling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a sigl. Transcriptiol activation occurs through the GLI family of proteins resulting in activation of target genes. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04340 PAGER curation team PAGER-contact@googlegroups.com 2336.49188081179 1.0 13-AUG-20 KEGG P 199
WAG001482 IL12-mediated signaling events 56 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=il12_2pathway&pathway_me=IL12-mediated sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 5062.55712708982 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001483 Neurotrophic factor-mediated Trk receptor signaling 44 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=trkrpathway&pathway_me=Neurotrophic factor-mediated Trk receptor sigling&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 2797.30009529977 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001484 EPHA2 forward signaling 16 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 3810.45318369091 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001485 S1P5 pathway 3 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001235 epo signaling pathway 9 Homo sapiens Thrombopoietin (TPO) binds to its receptor inducing aggregation and activation. TPO sigls its growth regulating effects to the cell through several major pathways including MAPK (ERK and JNK), Protein Kise C, and JAK/Stat. https://cgap.nci.nih.gov/Pathways/BioCarta/h_TPOPathway PAGER curation team PAGER-contact@googlegroups.com 2357.31073283537 1.0 13-AUG-20 BioCarta P 252
WAG001237 role of egf receptor transactivation by gpcrs in cardiac hypertrophy 26 Homo sapiens One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickness of the ventricular walls. Cardiac hypertrophy allows the heart to handle the increased stress caused by elevated blood pressure but is also a risk factor associated with heart disease. Cardiac hypertrophy results from cross-talk between G-protein coupled receptor sigling and the EGF receptor pathway. Several GPCR ligands are known to stimulate cardiac hypertrophy, including factors that regulate blood pressure such as angiotensin II and endothelin- 1. These factors stimulate phospholipase C through Gq activation, and the production of 1P3 and diacylglycerol second messengers. PKC-delta is activated by DAG and interacts with the metalloproteise ADAM12. ADAM12 cleaves the membrane-bound HB-EGF to release soluble EGF ligand that activates EGF receptor in myocardial cells. EGF receptor activation downstream through small G proteins and the MAP kise pathway ultimately leads to cardiac hypertrophy. Sigls by GPCR ligands such as angiotensin II result in transcriptiol translation of immediate early genes like fos and other genes involved in long-term remodeling of heart tissue and the physiological response to stress in the heart such as the atrial triuretic factor. Factors such as the AKT kise, reactive oxygen species (ROS) and NE-kB also are involved in sigling that leads to hypertrophy, although their role is not yet clear. Blocking this pathway at various steps may prevent heart disease through the prevention of cardiac hypertrophy, but may also have other consequences. https://cgap.nci.nih.gov/Pathways/BioCarta/h_cardiacegfPathway PAGER curation team PAGER-contact@googlegroups.com 3182.58961557505 1.0 13-AUG-20 BioCarta P 252
WAG001034 internal ribosome entry pathway 6 Homo sapiens Control of translation is one of the major regulatory events in eukaryotic gene expression. Interl ribosome entry sites (IRES) were first discovered in picorvirus Rs but it is now clear that IRESs are also present in the 5?untranslated region of many eukaryotic genes including those encoding: growth factors e.g. VEGF, FGF2 and PDGF; genes whose protein products are associated with apoptosis e.g. Apaf-1, IXAP;transcription factors e.g. c- myc; the potassium channel Kv1.4. IRES allows the ribosomes to be recruited to an initiator AUG, which is some distance from the 5' end of the message R to bypass the Kozak scanning mechanism.. In the Kozak scanning model, the 40S ribosomal subunit bearing Met-tRmet and initiation factors, binds near the capped 5¿d of the mR and travels along the mR until it comes to the first AUG. https://cgap.nci.nih.gov/Pathways/BioCarta/h_iresPathway PAGER curation team PAGER-contact@googlegroups.com 1744.99138319124 1.0 13-AUG-20 BioCarta P 252
WAG001252 cdc25 and chk1 regulatory pathway in response to dna damage 6 Homo sapiens Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into the M-phase of the cell cycle. Cdc25 is phosphorylated throughout interphase but not in mitosis. The primary site for phosphorylation of cdc25 is at Ser216. Phosphorylated cdc25 binds to members of the 14-3-3 family of proteins which prevents its activation of cdc2. Chk1, a protein kise involved in the D damage checkpoint response in fission yeast, has been shown to phosphorylate cdc25 at Ser216 in vitro. https://cgap.nci.nih.gov/Pathways/BioCarta/h_cdc25Pathway PAGER curation team PAGER-contact@googlegroups.com 273.733861995502 1.0 13-AUG-20 BioCarta P 252
WAG001253 chaperones modulate interferon signaling pathway 13 Homo sapiens Sigling by interferon-gamma stimulates anti-viral responses and tumor suppression through the heterodimeric interferon-gamma receptor. Sigling is initiated by binding of interferon-gamma to its receptor, activating the receptor-associated JAK2 tyrosine kise to phosphorylate STAT transcription factors that activate interferon responsive genes. Molecular chaperones that modulate or alter protein folding interact with different components of the interferon sigling pathway. One chaperone that modulates interferon sigling is hTid-1, a member of the DJ family of chaperones and a cochaperone for the heat shock protein Hsp70, another molecular chaperone. hTid-1 was found in a two-hybrid screen to bind to JAK2 and also to interact with the interferon-gamma receptor. In addition, hTid-1 and JAK2 also interact with Hsp70. Overexpression of hTid-1 represses transcriptiol activation by interferon-gamma and Hsp70 dissociates from these proteins when interferon is added to cells, suggesting that Hsp70 holds Jak2 in an ictive conformation prior to ligand activation, and is released in the presence of agonist to allow the activation of Jak-2 and downstream pathways. https://cgap.nci.nih.gov/Pathways/BioCarta/h_tidPathway PAGER curation team PAGER-contact@googlegroups.com 190.4293614033 1.0 13-AUG-20 BioCarta P 252
WAG001242 double stranded rna induced gene expression 11 Homo sapiens One defense against viral infection is provided by PKR, double-stranded R activated protein kise. When PKR interacts with dsR found in cells during viral infection, PKR phosphorylates itself and cellular proteins including the translation factor elF2a and the transcription factor NF-kB. The repression of translation caused by phosphorylation of elF2a prevents cells from producing viral proteins and creating infectious viral particles. PKR phosphorylation of I-kB kise activates NF-kB to induce transcription of inflammatory factors and stimulate an immune response that impedes viral infection. The PKR kise is induced by interferon and some of the anti-viral activity of interferon may be mediated by PKR. Some viruses have evolved mechanisms to ictivate PKR to promote successful infection. Another substrate of PKR, the tumor suppressor p53, may be involved in potential PKR regulation of the cell cycle and apoptosis. https://cgap.nci.nih.gov/Pathways/BioCarta/h_rPathway PAGER curation team PAGER-contact@googlegroups.com 327.540478389535 1.0 13-AUG-20 BioCarta P 252
GEX001201 non-small cell lung cancer 3 Homo sapiens non-small cell lung cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
NAX018010 NIF3L1 1 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 0.0 1.0 13-AUG-20 Genome Data N 17363
NAX015844 PIGB 1 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 0.0 1.0 13-AUG-20 Genome Data N 17363
GEX167671 Wilms tumor 3 Homo sapiens A genome-wide association study identifies susceptibility loci for Wilms tumor. http://www.ncbi.nlm.nih.gov/pubmed/22544364 Turnbull C,4/29/2012,Nat Genet 22544364.0 PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GWAS Catalog G 1230
WAG001244 inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages 32 Homo sapiens Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria in the lungs. CD14 and the Toll-like receptor TLR4 are activated by LPS, initiating a sigling cascade that activates PI3 kise and increases synthesis of the inositol phosphate PIP3 (see Toll-like Receptor pathway). PIP3 activates the inositol phosphate dependent protein kise PDK1, which activates AKT (protein kise B, see AKT Sigling Pathway). One of the key actions of AKT is to block apoptosis. AKT phosphorylation of NF-kB promotes the survival and activation of macrophages responding to LPS. Another substrate of AKT is the protein kise Gsk3-beta. AKT phosphorylates and deactivates Gsk3-beta. Non-phosphorylated Gsk3-beta is active and phosphorylates beta-catenin, leading to its degradation in the ubiquitin dependent proteosome pathway (see proteosome pathway). Stimulation by LPS causes the accumulation of beta-catenin in the nucleus and the activation of genes in concert with the transcription factor LEF1. This pathway is probably not restricted to alveolar pathway, but leads to the activation of beta-catenin dependent genes by LPS in other cells as well. Other pathways regulate this pathway also, such as the modulation of PI3 kise activity by ceramide, and the inhibition of Gsk3-beta activity by the Wnt/frizzled/disheveled (DSH) pathway. https://cgap.nci.nih.gov/Pathways/BioCarta/h_gsk3Pathway PAGER curation team PAGER-contact@googlegroups.com 1238.93485754241 1.0 13-AUG-20 BioCarta P 252
WAG001245 role of beta-arrestins in the activation and targeting of map kinases 10 Homo sapiens The binding of ?arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kise activation complex using ?arrestin as a scaffold, with subsequent activation of a ?arrestin-bound pool of ERK1/2. The receptor?arrestin¿K complexes are localized to endosomal vesicles, and their formation does not result in nuclear translocation of activated ERK1/2 or stimulation of cell proliferation. The function of ?arrestin-bound ERK1/2 is presently unknown. Activation of ERK1/2 by ?arrestin scaffolds may favor the phosphorylation of plasma membrane, cytosolic, or cytoskeletal ERK1/2 substrates, or it may lead to transcriptiol activation through the ERK-dependent activation of other kises. The model depicts ?arrestin scaffolding of the ERK1/2 MAP kise cascade, based upon data obtained with the protease-activated PAR2 and angiotensin AT1a receptors. A similar mechanism has been proposed for regulation of the JNK3 MAP kise cascade by AT1a receptors. https://cgap.nci.nih.gov/Pathways/BioCarta/h_barr-mapkPathway PAGER curation team PAGER-contact@googlegroups.com 1106.47965242305 1.0 13-AUG-20 BioCarta P 252
WAG001039 erythropoietin mediated neuroprotection through nf-kb 12 Homo sapiens Erythropoietin (Epo) is most commonly known as the cytokine secreted by the kidneys that stimulates red blood cell production and is used as a drug for the treatment of anemias. Epo is also secreted in the brain in response to hypoxia, such as ischemic stroke. Epo production in the brain is stimulated by the hypoxia-inducible transcription factor HIF-1 (see HIF pathway). Administration of Epo to the brain in rodents before hypoxic stress or other neurol stresses is neuroprotective, preventing neurol apoptosis. The erythropoietin receptor (EpoR) is known to associate with JAK kises that phosphorylate and activate the STAT family of transcription factors (See Epo pathway). The neuroprotection by Epo involves cross-talk between Epo receptor and anti-apoptotic pathways through activation of NF-kB by the JAK2 kise (see NF-kB pathway). Epo stimulates JAK2 phosphorylation of I-kB, releasing NF-kB to translocate into the nucleus and activate transcription of neuroprotective genes. Neuroprotective genes activated by NF-kB include the anti-oxidant enzyme manganese superoxide dismutase and calbindin-D(28k). The erythropoietin receptor is also essential for proper brain development in mice. The absence of EpoR causes high levels of neurol apoptosis in the developing mouse brain, further confirming the important role of Epo as a neuroprotective agent. https://cgap.nci.nih.gov/Pathways/BioCarta/h_eponfkbPathway PAGER curation team PAGER-contact@googlegroups.com 1577.25742158756 1.0 13-AUG-20 BioCarta P 252
WAG001040 transcription regulation by methyltransferase of carm1 11 Homo sapiens Several forms of post-translatiol modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptiol regulation. CARM1 associates with the p160 class of transcriptiol coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptiol coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translatiol protein modification such as phosphorylation are reversible in ture, but as of yet a protein demethylase is not known. https://cgap.nci.nih.gov/Pathways/BioCarta/h_carm1Pathway PAGER curation team PAGER-contact@googlegroups.com 969.917912276403 1.0 13-AUG-20 BioCarta P 252
WAG001226 ErbB signaling pathway 75 Homo sapiens The ErbB family of receptor tyrosine kises (RTKs) couples binding of extracellular growth factor ligands to intracellular sigling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kise domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Sigling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various sigling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kise (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kise (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kise Src, or the Cbl E3 ubiquitin protein ligase. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04012 PAGER curation team PAGER-contact@googlegroups.com 4583.14141447092 1.0 13-AUG-20 KEGG P 199
WAG001227 Phenylalanine metabolism 18 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00360 PAGER curation team PAGER-contact@googlegroups.com 957.818008109965 1.0 13-AUG-20 KEGG P 199
WAG001228 Methane metabolism 7 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00680 PAGER curation team PAGER-contact@googlegroups.com 185.042537578412 1.0 13-AUG-20 KEGG P 199
WAG001229 Glutamate metabolism 41 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00251 PAGER curation team PAGER-contact@googlegroups.com 2011.87841333939 1.0 13-AUG-20 KEGG P 199
WAG001230 Vitamin B6 metabolism 19 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00750 PAGER curation team PAGER-contact@googlegroups.com 1057.41749482439 1.0 13-AUG-20 KEGG P 199
WAG001231 Peptidoglycan biosynthesis 4 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00550 PAGER curation team PAGER-contact@googlegroups.com 35.7709251101322 1.0 13-AUG-20 KEGG P 199
WAG001232 Synthesis and degradation of ketone bodies 12 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00072 PAGER curation team PAGER-contact@googlegroups.com 2083.33730569352 1.0 13-AUG-20 KEGG P 199
WAG001233 Asthma 16 Homo sapiens Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, ive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05310 PAGER curation team PAGER-contact@googlegroups.com 1106.50758434571 1.0 13-AUG-20 KEGG P 199
WAG001234 Terpenoid biosynthesis 5 Homo sapiens Terpenoids, also known as isoprenoids, are a large class of tural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalote pathway [MD: http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00900 PAGER curation team PAGER-contact@googlegroups.com 882.508700274157 1.0 13-AUG-20 KEGG P 199
WAG001041 signal dependent regulation of myogenesis by corepressor mitr 4 Homo sapiens The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds to promoters to activate genes involved in muscle cell differentiation. One of the factors that regulates the role of MyoD/MEF2 in myogenesis is the protein MEF2-interacting transcription repressor (MITR), a transcriptiol repressor. When MITR is bound to MEF2, myogenesis genes are repressed rather than being activated. The transcriptiol repression by MITR occurs in part at least through interaction with the CtBP (carboxy-termil binding protein) corepressor. The inhibitory activity of MITR is itself regulated by the calmoldulin dependent protein kise CAMK. When CAMK is activated by factors such as IGF-1, it phosphorylates two specific residues in MITR, ser218 and ser448. Phosphorylated MITR does not bind to MEF2, but does bind to the protein 14-3-3, helping to block the repression of myogenesis. CAMK also plays a role in myogenesis through phosphorylation of histone deacetylase (HDAC, see Control of Skeletal Myogenesis pathway), in which HDAC alters chromatin to repress myogenesis. Like MITR, phosphorylation of HDAC removes the repression, allowing myogenesis to continue. MITR shares sequence homology with HDACs, but itself lacks the enzyme motif https://cgap.nci.nih.gov/Pathways/BioCarta/h_MITRPathway PAGER curation team PAGER-contact@googlegroups.com 226.45236784141 1.0 13-AUG-20 BioCarta P 252
WAG001042 spliceosomal assembly 7 Homo sapiens The assembly of the spliceosome is a dymic process that involves both small ribonucleoprotein particles (snRNPs), and non-snRNP proteins. The complete spliceosome consists of 5 snRNPs (U1, U2, U4, U5, and U6) and 50-100 non-snRNP factors. (Most are omitted here for simplicity.) The snRNPs themselves contain a snR and a number of different proteins. These proteins can be subdivided into two classes, those specific to the individual snRNP, and those common to all snRNPs. The later group consist of eight polypeptides; B, B? D1, D2, D3, E, F, and G, which bind together in a tight association, and are referred to as the sm proteins. While some of the particle-specific proteins have been well studied, i.e.U1-70K or U1-A, many have only been identified by their molecular weight and have yet to be cloned. These snRNP components are recruited to the pre-mR in an ordered manner, and begin with the recognition of exon-intron boundaries. The 5?end of the U1 snRNP recognizes the 5?splice site of the pre-mR. This interaction is mediated through conventiol base pairing. Subsequently snRNP U1 recognizes and binds to the conserved branch point Adenosine site. This step is the splicing cycle is called the commitment complex (CC) and is defined as point where the formation of a stable splicing complex ¿mmits?the spliceosome to assemble. Binding of the U1 snRNP encourages binding of U2 snRNP, and is helped by U2AF protein. SR proteins such as ASF/SF2 and SC35, or other intron bridging proteins, mediate the interaction between U1, U2 and U2AF. Binding of these factors facilitate recognition of the 3?splice site, and this whole complex is called the E (Early) complex. Spliceosomal A Complex is formed following recruitment of U2 snRNP to the branch point sequence. Meanwhile, snRNPs U4/U6 and U5 have formed a functiol tri-snRNP complex. The association of the tri-snRNP U4/U6-U5 with the pre-spliceosome creates the B complex. Several R:R interactions occur following this point, including the disassociation of the U4/U6 snRNP and the pairing of the 3?end of U6 with the 5?end of U2. These, and other, complex R rearrangements are required for mature spliceosomal formation, which is a pre requisite for the transesterification reactions that create the spliced mR. https://cgap.nci.nih.gov/Pathways/BioCarta/h_smPathway PAGER curation team PAGER-contact@googlegroups.com 1744.59486212349 1.0 13-AUG-20 BioCarta P 252
WAG000650 bioactive peptide induced signaling pathway 25 Homo sapiens Many different peptides act as sigling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pressure regulating peptide angiotensin. While these three proteins are distinct in their sequence and physiology, and act through different cell surface receptors, they share in a common class of cell surface receptors called G-protein coupled receptors (GPCRs). Other polypeptide ligands of GPCRs include vasopressin, oxytocin, somatostatin, neuropeptide Y, GnRH, leutinizing hormone, follicle stimulating hormone, parathyroid hormone, orexins, urotensin II, endorphins, enkephalins, and many others. GPCRs are a broad and diverse gene family that respond not only to peptide ligands but also small molecule neurotransmitters (acetylcholine, dopamine, serotonin and adreline), light, odorants, taste, lipids, nucleotides, and ions. The main sigling mechanism used by GPCRs is to interact with G-protein GTPase proteins coupled to downstream second messenger systems including intracellular calcium release and cAMP production. The intracellular sigling systems used by peptide GPCRs are similar to those used by all GPCRs, and are typically classified according to the G-protein they interact with and the second messenger system that is activated. For Gs-coupled GPCRs, activation of the G-protein Gs by receptor stimulates the downstream activation of adenylate cyclase and the production of cyclic AMP, while Gi-coupled receptors inhibit cAMP production. One of the key results of cAMP production is activation of protein kise A. Gq-coupled receptors stimulate phospholipase C, releasing IP3 and diacylglycerol. IP3 binds to a receptor in the ER to cause the release of intracellular calcium, and the subsequent activation of protein kise C, calmodulin-dependent pathways. In addition to these second messenger sigling systems for GPCRs, GPCR pathways exhibit crosstalk with other sigling pathways including tyrosine kise growth factor receptors and map kise pathways. Transactivation of either receptor tyrosine kises like the EGF receptor or focal adhesion complexes can stimulate ras activation through the adaptor proteins Shc, Grb2 and Sos, and downstream Map kises activating Erk1 and Erk2. Src kises may also play an essential intermediary role in the activation of ras and map kise pathways by GPCRs. https://cgap.nci.nih.gov/Pathways/BioCarta/h_biopeptidesPathway PAGER curation team PAGER-contact@googlegroups.com 4346.92517318526 1.0 13-AUG-20 BioCarta P 252
WAG000427 corticosteroids and cardioprotection 17 Homo sapiens Myocardial infarction damages heart tissue both during the initial ischemia and the subsequent reperfusion of tissues with oxygen. Corticosteroids can protect cardiac tissue from damage following a heart attack, but the mechanisms by which corticosteroids are cardioprotective have not been clear and negative side effects such as reduced wound healing may result from their use. Corticosteroids exert a variety of actions through binding to the glucocorticoid receptor (GR), a member of the steroid hormone receptor gene family. GR acts as a ligand-dependent transcription factor, but some of the cardioprotective effects mediated by GR-bound corticosteroids are non-transcriptiol in ture. Glucocorticoids are commonly used as anti-inflammatory drugs in a variety of conditions, and some of their effects in the heart result from inhibition of the inflammatory response of heart tissue to ischemia and reperfusion. NF-kB is a transcription factor involved in sigling by inflammatory factors such as TNF, and is repressed by glucocorticoids. Annexin-1 is a calcium-dependent phospholipid binding protein whose expression is induced by corticosteroids and inhibits the infiltration of neutrophils into tissue, blocking reperfusion-induced inflammatory heart damage. A non-transcriptiol cardioprotective effect of glucocorticoids is activation of NO production by endothelial nitric oxide synthase (eNOS). Glucocorticoids activate eNOS through activation of PI3 kise and AKT and increased NO produced by eNOS can diffuse into surrounding tissues to prevent clotting and cause vasodilation. The beta-2 adrenergic receptor can also activate PI3 kise and may synergize with glucocorticoids in this pathway. The atrial triuretic factor (ANF) is a peptide secreted by the atrial wall in response to increased atrial pressure such as occurs during cardiac failure and to be decreased by myocardial infarction. Glucocorticoids increase the secretion of ANF by acting at the transcriptiol level to increase expression of the pro-ANF peptide, perhaps inducing increased water excretion in the kidneys to reduce blood volume and reduce atrial pressure. The exploration of glucorticoid responses may allow the identification of compounds that retain the cardioprotective activities but do not inhibit wound healing. Altertive mechanisms of eNOS activation may also provide a route to identify cardioprotective drugs. https://cgap.nci.nih.gov/Pathways/BioCarta/h_gcrPathway PAGER curation team PAGER-contact@googlegroups.com 907.522531806644 1.0 13-AUG-20 BioCarta P 252
WAG001261 FOXA1 transcription factor network 34 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 612.029203320246 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001262 IL2 signaling events mediated by PI3K 34 Homo sapiens PAGER curation team PAGER-contact@googlegroups.com 4668.55844849058 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001263 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 12 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=hif1apathway&pathway_me=Hypoxic and oxygen homeostasis regulation of HIF-1-alpha&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1820.63561195053 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001264 TGF-beta receptor signaling 48 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 1603.26735782713 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001265 IL4-mediated signaling events 59 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=il4_2pathway&pathway_me=IL4-mediated sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1733.08337708225 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001266 Ceramide signaling pathway 47 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=ceramide_pathway&pathway_me=Ceramide sigling pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3208.28544896431 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001267 TNF receptor signaling pathway 35 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 4832.08691920152 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001268 Insulin-mediated glucose transport 17 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=insulin_pathway&pathway_me=Insulin Pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1222.32708140574 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001269 IGF1 pathway 29 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=igf1_pathway&pathway_me=IGF1 pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 6005.16253179782 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001270 FOXA transcription factor networks 3 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=hnf3pathway&pathway_me=FOXA transcription factor networks&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 59.7204968944099 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001271 ADP-ribosylation factor 1 pathway 17 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=100239&pathway_me=adp-ribosylation%20factor&source=BioCarta%20Imported&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1211.34414800311 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001272 Thromboxane A2 receptor signaling 29 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 1114.72180864448 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001274 Syndecan-2-mediated signaling events 30 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=syndecan_pathway&pathway_me=Proteoglycan%20syndecan-mediated%20sigling%20events&source=NCI-ture%20curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 1496.12941933551 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001275 IL27-mediated signaling events 26 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=il27pathway&pathway_me=IL27-mediated sigling events&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 6566.93210395989 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001276 Wnt signaling 2 Homo sapiens http://http://pid.nci.nih.gov PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG001277 Canonical NF-kappaB pathway 23 Homo sapiens http://pid.nci.nih.gov/search/pathway_landing.shtml?pathway_id=nfkappabcanonicalpathway&pathway_me=Canonical NF-kappaB pathway&source=NCI-ture curated&what=graphic&jpg=on&ppage=1 PAGER curation team PAGER-contact@googlegroups.com 3203.8897675577 1.0 13-AUG-20 NCI-Nature Curated P 132
WAG000428 er associated degradation (erad) pathway 10 Homo sapiens The endoplasmic reticulum (ER) of the cell operates a quality control system that identifies misfolded proteins, transports them into the cytoplasm and then targets them for degradation by the proteasome. Aberrant protein degradation is the mechanism underlying many diseases, including cystic fibrosis and heritable forms of lung and liver disease. The pathways that orchestrate the destruction of aberrant proteins are collectively termed ER-associated degradation (ERAD). https://cgap.nci.nih.gov/Pathways/BioCarta/h_eradPathway PAGER curation team PAGER-contact@googlegroups.com 146.496746228845 1.0 13-AUG-20 BioCarta P 252
WAG000429 il 2 signaling pathway 12 Homo sapiens Interleukin 2 (IL-2) is a potent cytokine that can lead to cellular activation and proliferation. IL-2 Receptors are found on activated B-Cells, LPS treated Monocytes, and many T cells. The receptor is formed from three chains alpha (CD25), beta (CD122), and gamma (CD132). Primary sigling is through the JAK/Stat pathway and MAPKs. https://cgap.nci.nih.gov/Pathways/BioCarta/h_il2Pathway PAGER curation team PAGER-contact@googlegroups.com 5435.78345175681 1.0 13-AUG-20 BioCarta P 252
WAG000430 antisense pathway 4 Homo sapiens About 8% of human genes have been estimated to carry out transcription from both D strands, resulting in significant level of endogenous antisense R. In cytoplasm the antisense R leads to formation of long dsR, which activates the interferon and R-dependent protein kise antiviral pathway. Most endogenous antisense R is made in nucleus and two responses have been suggested for the nuclear dsR. First, the dsR may be processed by enzymes of the family of adensoine deamises that act on R (ADAR). The deamited dsRs contain various levels of inosines. dsR containing high level of inosines are tightly bound by a protein complex that results in their nuclear retention. dsR containing low level of inosines may be able to exit the nucleus. Second, the nuclear dsR can lead to gene silencing and heterochromatin formation. https://cgap.nci.nih.gov/Pathways/BioCarta/h_antisensePathway PAGER curation team PAGER-contact@googlegroups.com 282.003028634361 1.0 13-AUG-20 BioCarta P 252
GEX000802 hematology indices 3 Homo sapiens hematology indices associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 17.1866295264624 N 1.0 13-AUG-20 GAD G 1671
GEX000803 hematopoietic stem cell transplantation 2 Homo sapiens hematopoietic stem cell transplantation associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000804 hemochromatosis 2 Homo sapiens hemochromatosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000805 hemoglobin 7 Homo sapiens hemoglobin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 12.8588235294118 N 1.0 13-AUG-20 GAD G 1671
GEX000806 hemoglobin a, glycosylated 200 Homo sapiens hemoglobin a, glycosylated associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000808 hemoglobins 282 Homo sapiens hemoglobins associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000832 high total ige 1 Homo sapiens high total ige associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000833 high-altitude pulmonary edema 1 Homo sapiens high-altitude pulmonary edema associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000834 higher sperm counts 2 Homo sapiens higher sperm counts associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000835 hip 414 Homo sapiens hip associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000837 hippocampal atrophy 14 Homo sapiens hippocampal atrophy associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000838 hippocampus 48 Homo sapiens hippocampus associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.672219472830006 N 1.0 13-AUG-20 GAD G 1671
GEX000840 hirschsprung's disease 5 Homo sapiens hirschsprung's disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 109.155904448384 N 1.0 13-AUG-20 GAD G 1671
WAG000431 chrebp regulation by carbohydrates and camp 18 Homo sapiens https://cgap.nci.nih.gov/Pathways/BioCarta/h_Chrebp.2Pathway PAGER curation team PAGER-contact@googlegroups.com 2006.67381289485 1.0 13-AUG-20 BioCarta P 252
GEX000841 hiv 33 Homo sapiens hiv associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 521.491789492096 N 1.0 13-AUG-20 GAD G 1671
GEX000842 hiv infection 2 Homo sapiens hiv infection associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000843 hiv infections 5 Homo sapiens hiv infections associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 53.7883959044369 N 1.0 13-AUG-20 GAD G 1671
GEX000844 hiv infections|[x]human immunodeficiency virus disease 2 Homo sapiens hiv infections|[x]human immunodeficiency virus disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000845 hiv-1 73 Homo sapiens hiv-1 associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000846 hiv-1 control 14 Homo sapiens hiv-1 control associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 23.547300713895 N 1.0 13-AUG-20 GAD G 1671
GEX000848 hodgkin disease 7 Homo sapiens hodgkin disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 9.91853360488798 N 1.0 13-AUG-20 GAD G 1671
GEX000849 hodgkin lymphoma 3 Homo sapiens hodgkin lymphoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000850 hodgkin's disease 3 Homo sapiens hodgkin's disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 134.16149068323 N 1.0 13-AUG-20 GAD G 1671
GEX000851 homocysteine 5 Homo sapiens homocysteine associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 188.558607956135 N 1.0 13-AUG-20 GAD G 1671
GEX001259 pah-dna adducts 2 Homo sapiens pah-dna adducts associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001260 pain 2 Homo sapiens pain associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001262 pain response 1 Homo sapiens pain response associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001263 palmoplanta pustulosis 3 Homo sapiens palmoplanta pustulosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX001264 palmoplantar pustulosis 1 Homo sapiens palmoplantar pustulosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001265 pancreatic cancer 12 Homo sapiens pancreatic cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 33.953642384106 N 1.0 13-AUG-20 GAD G 1671
GEX001266 pancreatic neoplasms 122 Homo sapiens pancreatic neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000764 graves' disease; hashimoto's thyroiditis 2 Homo sapiens graves' disease; hashimoto's thyroiditis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000273 body composition 61 Homo sapiens body composition associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0639050553463426 N 1.0 13-AUG-20 GAD G 1671
GEX000274 body fat 3 Homo sapiens body fat associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000275 body fat distribution 114 Homo sapiens body fat distribution associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000276 body height 642 Homo sapiens body height associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000277 body mass 24 Homo sapiens body mass associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 830.920262335704 N 1.0 13-AUG-20 GAD G 1671
GEX000278 body mass diabetes, type 2 insulin 2 Homo sapiens body mass diabetes, type 2 insulin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000279 body mass index 554 Homo sapiens body mass index associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000280 body mass insulin 2 Homo sapiens body mass insulin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000281 body mass leptin obesity 2 Homo sapiens body mass leptin obesity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000282 body mass obesity 4 Homo sapiens body mass obesity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000283 body mass; diabetes, type 2 2 Homo sapiens body mass; diabetes, type 2 associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000285 body mass; insulin; glucose 2 Homo sapiens body mass; insulin; glucose associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000286 body mass; triglycerides; blood pressure, arterial 3 Homo sapiens body mass; triglycerides; blood pressure, arterial associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000289 body weights and measures 163 Homo sapiens body weights and measures associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000290 bone density 196 Homo sapiens bone density associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 24.8560659303265 N 1.0 13-AUG-20 GAD G 1671
GEX000292 bone density; fractures 3 Homo sapiens bone density; fractures associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000293 bone density; fractures, vertebral 2 Homo sapiens bone density; fractures, vertebral associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000295 bone density; spondylosis, lumbar 2 Homo sapiens bone density; spondylosis, lumbar associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000296 bone fractures 2 Homo sapiens bone fractures associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000297 bone loss 3 Homo sapiens bone loss associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000298 bone marrow transplantation 3 Homo sapiens bone marrow transplantation associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000299 bone mass 10 Homo sapiens bone mass associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 136.734051289708 N 1.0 13-AUG-20 GAD G 1671
GEX000301 bone mineral density 27 Homo sapiens bone mineral density associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 637.331501663973 N 1.0 13-AUG-20 GAD G 1671
GEX000302 bone mineral density (bmd) 2 Homo sapiens bone mineral density (bmd) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000818 hepatitis c 16 Homo sapiens hepatitis c associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 124.980055935079 N 1.0 13-AUG-20 GAD G 1671
GEX000819 hepatitis c virus infection 2 Homo sapiens hepatitis c virus infection associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000820 hepatitis c, chronic 22 Homo sapiens hepatitis c, chronic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 45.4272946684515 N 1.0 13-AUG-20 GAD G 1671
GEX000821 hepatitis c, chronic|liver cirrhosis 2 Homo sapiens hepatitis c, chronic|liver cirrhosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000823 hepatitis, autoimmune 1 Homo sapiens hepatitis, autoimmune associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000824 hepatocellular carcinoma 7 Homo sapiens hepatocellular carcinoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 48.1647058823529 N 1.0 13-AUG-20 GAD G 1671
GEX001256 p-selectin 18 Homo sapiens p-selectin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001257 paclitaxel pharmacokinetics 2 Homo sapiens paclitaxel pharmacokinetics associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
WAG000644 role of brca1 brca2 and atr in cancer susceptibility 21 Homo sapiens BRCA1 and BRCA2 were identified genetically as breast cancer susceptibility genes when a single copy of the gene is mutated and are involved in the cellular response to D damage, including blocking cell cycle progression and inducing D repair to preserve the integrity of the genome during cell division. BRCA1 and BRCA2 induce double-stranded repair of breaks using homologous recombition, in part through activation of RAD51. BRCA1 acts as a ubiquitin ligase targeting the protein FancD2 that activates checkpoint control, integrating the ATM response to ionizing radiation and the FA response to cross-linking agents like mitomycin C. Mutation of one of the several components of the FA complex involved in maintaining integrity of the genome leads to the condition Fanconi anemia. One member of the FA complex was recently identified as BRCA2, which leads to Fanconi anemia when both copies of the gene are mutated. Another related factor involved in the response of cells to D damage is the kise ATM (see ¿M Sigling Pathway?and ¿c25 and chk1 Regulatory Pathway in response to D damage?pathway). ATM is mutated in patients with AT, a condition with many similar traits to Fanconi anemia. Like ATM, ATR serves as a checkpoint kise that halts cell cycle progression and induces D repair when D is damaged. Loss of ATR results in a loss of checkpoint control in response to D damage, leading to cell death, and deletion of the ATR gene in mice is embryonic lethal. ATRIP is a protein that interacts with ATR and is a substrate for its kise activity. ATRIP is required for ATR function, and removal of ATRIP also leads to a loss of checkpoint control of the cell cycle. ATR and ATM kise targets include repair enzymes like Rad51, and the checkpoint kises Chk1 and Chk2, as well as BRCA1 and BRCA2. The close relationship of the genes involved in breast cancer and Fanconi anemia has helped illumite this sigling system, and may help lead to improved understanding and treatment of these conditions. https://cgap.nci.nih.gov/Pathways/BioCarta/h_atrbrcaPathway PAGER curation team PAGER-contact@googlegroups.com 5956.81576926631 1.0 13-AUG-20 BioCarta P 252
WAG001607 Graft-versus-host disease 24 Homo sapiens Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells. GVHD pathophysiology can be summerized in a three-step process. Step 1 involves the development of an inflammatory milieu resulting from damage in the host tissues induced by the preparative chemotherapy or radiotherapy regimen. Damaged tissues secrete inflammatory cytokines, including interleukin 1 (IL-1), and tumor necrosis factor (TNF-alpha ). During step 2, antigen-presenting cells (APCs) trigger the activation of donor-derived T cells, which induce further T-cell expansion, induce cytotoxic T lymphocytes (CTL) and tural killer (NK) cells responses and prime additiol mononuclear phagocytes to produce TNF-alpha and IL-1. Also, nitric oxide (NO) is produced by activated macrophages, and it may contribute to the tissue damage seen during step 3. During step 3, the effector phase, activated CTL and NK cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions and perforin-granzyme B. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05332 PAGER curation team PAGER-contact@googlegroups.com 2761.21315673705 1.0 13-AUG-20 KEGG P 199
WAG001608 Taste transduction 46 Homo sapiens All taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. + salt depolarizes taste cells by passive influx of + through the amiloride-sensitive + channel (EC). Acids depolarize taste cells by a variety of mechanisms, including influx of protons (H+) through EC and a proton-gated cation channel (MDEG). Two putative umami receptors have been identified: a truncated variant of the metabotropic glutamate receptor mGluR4 and the heterodimer, T1R1 + T1R3. Umami receptors are coupled to a sigling pathway involving activation of PLCbeta2, production of IP3 and diacylglycerol, release of Ca2+ from intracellular stores and activation of a transient receptor potential channel, TRPM5. Bitter compounds, such as detonium and PROP, activate particular T2R/TRB isoforms, which activate gustducin heterotrimers. Activated alpha-gustducin stimulates PDE to hydrolyze cAMP, whereas betagamma subunits activate PLCbeta2 to generate IP3, which leads to release of Ca2+ from interl stores. Artificial sweeteners activate GPCRs (T1R heterodimers) apparently linked via PLC to IP3 production and release of Ca2+ from intracellular stores. Sugars apparently activate GPCRs linked via AC to cAMP production which, in turn, may inhibit basolateral K+ channels through phosphorylation by cAMP-activated protein kise A (PKA). http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04742 PAGER curation team PAGER-contact@googlegroups.com 371.622931918813 1.0 13-AUG-20 KEGG P 199
WAG000646 cell cycle: g1/s check point 25 Homo sapiens The G1/S cell cycle checkpoint controls the passage of eukaryotic cells from the first 'gap' phase (G1) into the D synthesis phase (S). Two cell cycle kises, CDK4/6-cyclin D and CDK2-cyclin E, and the transcription complex that includes Rb and E2F are pivotal in controlling this checkpoint. During G1 phase, the Rb-HDAC repressor complex binds to the E2F-DP1 transcription factors, inhibiting the downstream transcription. Phosphorylation of Rb by CDK4/6 and CDK2 dissociates the Rb-repressor complex, permitting transcription of S-phase genes encoding for proteins that amplify the G1 to S phase switch and that are required for D replication. Many different stimuli exert checkpoint control including TGFb, D damage, contact inhibition, replicative senescence, and growth factor withdrawal. The first four act by inducing members of the INK4 or Kip/Cip families of cell cycle kise inhibitors. TGFb additiolly inhibits the transcription of Cdc25A, a phosphatase that activates the cell cycle kises. Growth factor withdrawal activates GSK3b, which phosphorylates cyclin D, leading to its rapid ubiquitition and proteosomal degradation. Ubiquitition, nuclear export, and degradation are mechanisms commonly used to rapidly reduce the concentration of cell-cycle control proteins. https://cgap.nci.nih.gov/Pathways/BioCarta/h_g1Pathway PAGER curation team PAGER-contact@googlegroups.com 5704.54793471775 1.0 13-AUG-20 BioCarta P 252
WAG000647 transcriptional activation of dbpb from mrna 4 Homo sapiens Endothelial cells respond to treatment with the protease thrombin with increased secretion of the PDGF B-chain. This activation occurs at the transcriptiol level and a thrombin response element was identified in the promoter of the PDGF B-chain gene. A transcription factor called the D-binding protein B (dbpB) mediates the activation of PDGF B-chain transcription in response to thrombin treatment. DbpB is a member of the Y box family of transcription factors and binds to both R and D. In the absence of thrombin, endothelial cells contain a 50 kD form of dbpB that binds R in the cytoplasm and may play a role as a chaperone for mR. The 50 kD version of dbpB also binds D to regulate genes containing Y box elements in their promoters. Thrombin activation results in the cleavage of dbpB to a 30 kD form. The proteolytic cleavage releases dbpB from R in the nucleus, allowing it to enter the nucleus and binds to a regulatory element distinct from the site recognized by the full length 50 kD dbpB. The genes activated by cleaved dbpB include the PDGF B chain. Dephosphorylation of dbpB also regulates nuclear entry and transcriptiol activation. https://cgap.nci.nih.gov/Pathways/BioCarta/h_dbpbPathway PAGER curation team PAGER-contact@googlegroups.com 282.003028634361 1.0 13-AUG-20 BioCarta P 252
WAG000648 alternative complement pathway 9 Homo sapiens The complement system of plasma proteins is an important part of the immune system that forms a cascade of factors that lyses foreign cells. There are two branches of the complement system, the classical pathway that is initiated by antibody-antigen complexes on a cell and the altertive pathway that is antibody independent. The ultimate result in either pathway is the creation of the membrane attack complex, a large pore in the cell membrane that results in cell lysis. https://cgap.nci.nih.gov/Pathways/BioCarta/h_altertivePathway PAGER curation team PAGER-contact@googlegroups.com 2125.00348476677 1.0 13-AUG-20 BioCarta P 252
WAG000645 erk1/erk2 mapk signaling pathway 22 Homo sapiens The p44/42 MAP Kise pathway consists of a protein kise cascade linking growth and differentiation sigls with transcription in the nucleus. Growth factor receptors and tyrosine kises activate Ras which in turn activates c-Raf, MEK, and MAP kise. Activated p44/42 MAP Kise translocates to the nucleus and activates transcription by phosphorylation of kises such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, MEK and by their effects on development. Sigl amplification and the potential for crosstalk appear to be important features of this regulatory network. https://cgap.nci.nih.gov/Pathways/BioCarta/h_erkPathway PAGER curation team PAGER-contact@googlegroups.com 2446.1382624346 1.0 13-AUG-20 BioCarta P 252
WAG000649 pelp1 modulation of estrogen receptor activity 4 Homo sapiens Proline-,glutamic acid-,leucine-rich protein 1 (Pelp1 also known as:modulator of nongenomic activity of estrogen or MR) is a recently discovered transmitter of estrogen sigls. The receptors for estrogen (ER), progestin (PR), androgen (AR) and others are steroid hormone receptors, which are part of a large family of ligand-inducible transcription factors. It has been established that estrogen has at least two courses of action termed classical or genomic and nongenomic. The classical activation cascade is well known and an example of this is illustrated in the https://cgap.nci.nih.gov/Pathways/BioCarta/h_pelp1Pathway PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 1.0 13-AUG-20 BioCarta P 252
WAG000029 activation of camp-dependent protein kinase pka 9 Homo sapiens G-protein coupled receptors (GPCRs) are one of the largest gene families of sigling proteins. Residing in the plasma membrane with seven transmembrane domains, GPCRs respond to extracellular stimuli that include catecholamine neurotransmitters, neuropeptides, larger protein hormones, lipids, nucleotides and other biological molecules. When a GPCR binds its extracellular ligand, it interacts with a G-protein to transduce a sigl across the membrane into the cellular interior. G-proteins are a heterotrimeric complex containing a Ga subunit with GTPase activity, as well as b and g subunits. Ga can exist in an active state and an ictive state. Ga in the off state has GDP bound and does not activate downstream sigling molecules. When a GPCR is activated by ligand, it stimulates Ga subunits to bind GTP instead of GDP and become active, dissociating from the receptor and from the b/g subunits to activate downstream sigling factors like the enzyme adenylyl cyclase that synthesizes cyclic-AMP (cAMP) from ATP. Ga turns itself back off again with its intrinsic GTPase activity, hydrolyzing GTP to GDP to become ictive again. https://cgap.nci.nih.gov/Pathways/BioCarta/h_gsPathway PAGER curation team PAGER-contact@googlegroups.com 3613.12807687666 1.0 13-AUG-20 BioCarta P 252
WAG001609 Cell adhesion molecules (CAMs) 105 Homo sapiens Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neurol tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, mely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordited brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain sypses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04514 PAGER curation team PAGER-contact@googlegroups.com 1302.49863508979 1.0 13-AUG-20 KEGG P 199
WAG001610 Basal cell carcinoma 48 Homo sapiens Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog sigling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog sigling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05217 PAGER curation team PAGER-contact@googlegroups.com 7007.26572516999 1.0 13-AUG-20 KEGG P 199
WAG001611 Renal cell carcinoma 56 Homo sapiens Rel cell cancer (RCC) accounts for ~3% of human maligncies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to rel cancer accounts for 1-4% of cases. RCC is not a single disease, it has several morphological subtypes. Conventiol RCC (clear cell RCC) accounts for ~80% of cases, followed by papillary RCC (10-15%), chromophobe RCC (5%), and collecting duct RCC (<1%). Genes potentially involved in sporadic neoplasms of each particular type are VHL, MET, BHD, and FH respectively. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. Activated MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Loss of functiol FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventiol (clear cell) RCC. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05211 PAGER curation team PAGER-contact@googlegroups.com 3268.42726964554 1.0 13-AUG-20 KEGG P 199
WAG001612 Acute myeloid leukemia 49 Homo sapiens Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clol neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death. Two major types of genetic events have been described that are crucial for leukemic transformation. A proposed necessary first event is disordered cell growth and upregulation of cell survival genes. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis. Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. In other cases, the transcription factors themselves are mutated. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05221 PAGER curation team PAGER-contact@googlegroups.com 2487.75104895105 1.0 13-AUG-20 KEGG P 199
WAG001613 Caffeine metabolism 16 Homo sapiens http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00232 PAGER curation team PAGER-contact@googlegroups.com 669.350011420933 1.0 13-AUG-20 KEGG P 199
FAX000516 Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNCAMAACACRNA which matches annotation for FALZ: fetal Alzheimer antigen 210 Homo sapiens Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NNNCAMAACACRNA which matches annotation for FALZ: fetal Alzheimer antigen http://www.broadinstitute.org/gsea/msigdb/cards/V$FAC1_01 M8826 C3: motif gene sets TFT: transcription factor targets PAGER curation team PAGER-contact@googlegroups.com Xiaohui Xie (Broad Institute) CURRENT 4.31200821074239 N 1.0 13-AUG-20 MSigDB A 13229
GEX001009 lipoprotein 9 Homo sapiens lipoprotein associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 723.707065333836 N 1.0 13-AUG-20 GAD G 1671
GEX001467 sclerosis 9 Homo sapiens sclerosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 18.2764811490126 N 1.0 13-AUG-20 GAD G 1671
GEX000543 decreased airway responsiveness 1 Homo sapiens decreased airway responsiveness associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001498 sickle cell disease 2 Homo sapiens sickle cell disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000573 diabetes, type 2 160 Homo sapiens diabetes, type 2 associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 585.694695829261 N 1.0 13-AUG-20 GAD G 1671
GEX001070 malaria, plasmodium falciparum 5 Homo sapiens malaria, plasmodium falciparum associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 109.155904448384 N 1.0 13-AUG-20 GAD G 1671
GEX000603 drug hypersensitivity 7 Homo sapiens drug hypersensitivity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 147.829257900343 N 1.0 13-AUG-20 GAD G 1671
GEX001560 tacrolimus pharmcokinetics 2 Homo sapiens tacrolimus pharmcokinetics associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001129 monocyte chemoattractant protein 1 (66-77) 96 Homo sapiens monocyte chemoattractant protein 1 (66-77) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.348267145984078 N 1.0 13-AUG-20 GAD G 1671
GEX000665 exercise test 133 Homo sapiens exercise test associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.241364740678145 N 1.0 13-AUG-20 GAD G 1671
GEX001160 myopia 10 Homo sapiens myopia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000210 autoimmune hypothyroidism 1 Homo sapiens autoimmune hypothyroidism associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000697 floxacillin 2 Homo sapiens floxacillin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000730 genetic polymorphism 2 Homo sapiens genetic polymorphism associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001222 ocular physiological phenomena 10 Homo sapiens ocular physiological phenomena associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000762 graves' disease 18 Homo sapiens graves' disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 444.507825799818 N 1.0 13-AUG-20 GAD G 1671
GEX000272 bmi rosiglitazone or pioglitazone 2 Homo sapiens bmi rosiglitazone or pioglitazone associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000287 body weight 407 Homo sapiens body weight associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000300 bone mass; osteoporotic fractures 1 Homo sapiens bone mass; osteoporotic fractures associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
WAG001614 Bile acid biosynthesis 32 Homo sapiens Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa00120 PAGER curation team PAGER-contact@googlegroups.com 775.309804524219 1.0 13-AUG-20 KEGG P 199
WAG001615 p53 signaling pathway 60 Homo sapiens p53 activation is induced by a number of stress sigls, including D damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptiol activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged D or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other sigl transduction pathways. http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04115 PAGER curation team PAGER-contact@googlegroups.com 1801.10706948073 1.0 13-AUG-20 KEGG P 199
WAG001616 Colorectal cancer 73 Homo sapiens Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and ictivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from ictivation of the D mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated D mismatch repair genes in HNPCC). http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05210 PAGER curation team PAGER-contact@googlegroups.com 3423.75742043578 1.0 13-AUG-20 KEGG P 199
GEX000763 graves' disease ige 2 Homo sapiens graves' disease ige associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000765 growth disorders 2 Homo sapiens growth disorders associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000766 gstm1 methylation infertility, male 1 Homo sapiens gstm1 methylation infertility, male associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000767 guillain-barre syndrome 2 Homo sapiens guillain-barre syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000768 gvhd 2 Homo sapiens gvhd associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000769 h. pylori infection 9 Homo sapiens h. pylori infection associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 64.3701612602187 N 1.0 13-AUG-20 GAD G 1671
GEX000771 hair 18 Homo sapiens hair associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.47263249348393 N 1.0 13-AUG-20 GAD G 1671
GEX000774 hand strength 18 Homo sapiens hand strength associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000775 haptoglobin 2 Homo sapiens haptoglobin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000776 harm avoidance 2 Homo sapiens harm avoidance associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000777 hdl cholesterol 32 Homo sapiens hdl cholesterol associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 642.822941750281 N 1.0 13-AUG-20 GAD G 1671
GEX000778 head and neck cancer 17 Homo sapiens head and neck cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 149.993599465913 N 1.0 13-AUG-20 GAD G 1671
GEX000779 head and neck cancer lung cancer 10 Homo sapiens head and neck cancer lung cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 504.749925342491 N 1.0 13-AUG-20 GAD G 1671
GEX000781 hearing impairment 1 Homo sapiens hearing impairment associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000783 hearing loss, noise-induced 3 Homo sapiens hearing loss, noise-induced associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000784 hearing loss, sensorineural 2 Homo sapiens hearing loss, sensorineural associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000785 hearing loss, sensorineural nonsyndromic 4 Homo sapiens hearing loss, sensorineural nonsyndromic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 226.45236784141 N 1.0 13-AUG-20 GAD G 1671
GEX000786 hearing loss/deafness 5 Homo sapiens hearing loss/deafness associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 53.7883959044369 N 1.0 13-AUG-20 GAD G 1671
GEX000787 heart anomalies, congenital 7 Homo sapiens heart anomalies, congenital associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 48.1647058823529 N 1.0 13-AUG-20 GAD G 1671
GEX000788 heart disease, ischemic 9 Homo sapiens heart disease, ischemic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 47.8410914927769 N 1.0 13-AUG-20 GAD G 1671
GEX000789 heart disease, ischemic stroke, ischemic 2 Homo sapiens heart disease, ischemic stroke, ischemic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000790 heart disease, ischemic; peripheral vascular disease 2 Homo sapiens heart disease, ischemic; peripheral vascular disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001278 parkinson's disease (age of onset) 6 Homo sapiens parkinson's disease (age of onset) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001279 parkinson's disease (familial) 2 Homo sapiens parkinson's disease (familial) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001281 parkinson's disease; hallucinations 2 Homo sapiens parkinson's disease; hallucinations associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001283 partial thromboplastin time 3 Homo sapiens partial thromboplastin time associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 134.16149068323 N 1.0 13-AUG-20 GAD G 1671
GEX001284 parvovirus b19 infection 3 Homo sapiens parvovirus b19 infection associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX001322 plasma levels of liver enzymes 16 Homo sapiens plasma levels of liver enzymes associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 20.8732275752011 N 1.0 13-AUG-20 GAD G 1671
GEX001337 polysaccharides 5 Homo sapiens polysaccharides associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 23.9931740614334 N 1.0 13-AUG-20 GAD G 1671
GEX000396 chagas cardiomyopathy 3 Homo sapiens chagas cardiomyopathy associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000827 hereditary and sporadic prostate cancer susceptibility 2 Homo sapiens hereditary and sporadic prostate cancer susceptibility associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000828 hereditary hemochromatosis 1 Homo sapiens hereditary hemochromatosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000829 hereditary hemolytic anemia 2 Homo sapiens hereditary hemolytic anemia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000831 herpesvirus, kaposi sarcoma-associated 1 Homo sapiens herpesvirus, kaposi sarcoma-associated associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
FEX001920 Lung Vicent08 03genes 2 Homo sapiens SuppFigure2b. Identity list of genes with a FDR https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18381434-SuppFigure2b 18381434.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FAX002946 FPKM over or equal to 50 tissue specific expression (Artery - Tibial) from NGS 12 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 0.0 2.0 13-AUG-20 GTEx A 92
FAX002947 FPKM over or equal to 50 tissue specific expression (Nerve - Tibial) from NGS 35 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 2.27012758468984 2.0 13-AUG-20 GTEx A 92
FAX002948 FPKM over or equal to 50 tissue specific expression (Brain - Hypothalamus) from NGS 10 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 53.6067705879027 2.0 13-AUG-20 GTEx A 92
FAX002949 FPKM over or equal to 50 tissue specific expression (Liver) from NGS 185 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 452.37590909506 2.0 13-AUG-20 GTEx A 92
FAX002944 FPKM over or equal to 50 tissue specific expression (Artery - Aorta) from NGS 22 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 0.0 2.0 13-AUG-20 GTEx A 92
FAX002950 FPKM over or equal to 50 tissue specific expression (Brain - Cortex) from NGS 7 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 0.0 2.0 13-AUG-20 GTEx A 92
FAX002943 FPKM over or equal to 50 tissue specific expression (Esophagus - Mucosa) from NGS 42 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 0.0 2.0 13-AUG-20 GTEx A 92
FAX002945 FPKM over or equal to 50 tissue specific expression (Thyroid) from NGS 38 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 20.3077809502721 2.0 13-AUG-20 GTEx A 92
FAX002942 FPKM over or equal to 50 tissue specific expression (Pituitary) from NGS 58 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 8.05877498308385 2.0 13-AUG-20 GTEx A 92
FAX002938 FPKM over or equal to 50 tissue specific expression (Cells - Transformed fibroblasts) from NGS 78 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 9.76710469245145 2.0 13-AUG-20 GTEx A 92
FAX002937 FPKM over or equal to 50 tissue specific expression (Small Intestine - Terminal Ileum) from NGS 41 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 3.22967403521918 2.0 13-AUG-20 GTEx A 92
FAX002940 FPKM over or equal to 50 tissue specific expression (Pancreas) from NGS 52 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 54.5519363003255 2.0 13-AUG-20 GTEx A 92
FAX002939 FPKM over or equal to 50 tissue specific expression (Brain - Cerebellum) from NGS 8 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 0.0 2.0 13-AUG-20 GTEx A 92
GEX000410 cholesterol cholesterol, hdl cholesterol, ldl 2 Homo sapiens cholesterol cholesterol, hdl cholesterol, ldl associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000897 inattentive symptoms 3 Homo sapiens inattentive symptoms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000911 inflammatory urogenital disease 2 Homo sapiens inflammatory urogenital disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001351 premature coronary artery disease 2 Homo sapiens premature coronary artery disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001366 prostate carcinoma 3 Homo sapiens prostate carcinoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000431 chronic obstructive pulmonary disease/copd 22 Homo sapiens chronic obstructive pulmonary disease/copd associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 146.348119466209 N 1.0 13-AUG-20 GAD G 1671
GEX000447 cleft lip 14 Homo sapiens cleft lip associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.43441762854145 N 1.0 13-AUG-20 GAD G 1671
GEX000941 invitro fertilization 1 Homo sapiens invitro fertilization associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
FAX002936 FPKM over or equal to 50 tissue specific expression (Brain - Nucleus accumbens (basal ganglia)) from NGS 10 Homo sapiens http://www.gtexportal.org/ 23715323.0 PAGER curation team PAGER-contact@googlegroups.com Tan 0.0 2.0 13-AUG-20 GTEx A 92
WAG001514 Nuclear import of Rev protein 27 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Nuclear%2520import%2520of%2520Rev%2520protein&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 14461.6528353119 1.0 13-AUG-20 Reactome P 528
WAG001518 NGF-independant TRKA activation 3 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=NGF-independant%2520TRKA%2520activation&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 Reactome P 528
WAG001519 Nef Mediated CD4 Down-regulation 7 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Nef%2520Mediated%2520CD4%2520Down-regulation&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 762.891111374127 1.0 13-AUG-20 Reactome P 528
WAG001522 Generic Transcription Pathway 20 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Generic%2520Transcription%2520Pathway&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 5970.46559075696 1.0 13-AUG-20 Reactome P 528
GEX001380 psychoses schizophrenia 3 Homo sapiens psychoses schizophrenia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX001394 quantitative traits 21 Homo sapiens quantitative traits associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 17.687132028656 N 1.0 13-AUG-20 GAD G 1671
GEX001408 recurrent pregnancy loss 4 Homo sapiens recurrent pregnancy loss associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 756.782075991189 N 1.0 13-AUG-20 GAD G 1671
GEX000455 clinical parameters and endocrine status in elderly men 3 Homo sapiens clinical parameters and endocrine status in elderly men associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000473 colon cancer 3 Homo sapiens colon cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000959 kidney cancer 11 Homo sapiens kidney cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 234.138126024918 N 1.0 13-AUG-20 GAD G 1671
GEX000972 laryngeal cancer 3 Homo sapiens laryngeal cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX001415 renal function and chronic kidney disease 4 Homo sapiens renal function and chronic kidney disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 GAD G 1671
GEX001432 response to radiation 9 Homo sapiens response to radiation associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000007 acenocoumarol 4 Homo sapiens acenocoumarol associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 GAD G 1671
GEX000791 heart diseases 19 Homo sapiens heart diseases associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000792 heart failure 383 Homo sapiens heart failure associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001225 oocytes 7 Homo sapiens oocytes associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001226 optic disk 14 Homo sapiens optic disk associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001228 oral cancer 17 Homo sapiens oral cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 581.01487549359 N 1.0 13-AUG-20 GAD G 1671
GEX001229 oral cancer; oral submucous fibrosis 2 Homo sapiens oral cancer; oral submucous fibrosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001230 oral submucous fibrosis 2 Homo sapiens oral submucous fibrosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001232 ossification of the posterior longitudinal ligament of the spine 2 Homo sapiens ossification of the posterior longitudinal ligament of the spine associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001233 osteitis deformans 3 Homo sapiens osteitis deformans associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001234 osteoarthritis 22 Homo sapiens osteoarthritis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 109.527939380881 N 1.0 13-AUG-20 GAD G 1671
GEX001235 osteoarthritis, knee 4 Homo sapiens osteoarthritis, knee associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001236 osteomyelitis 2 Homo sapiens osteomyelitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001237 osteomyelitis|unspecified osteomyelitis nos 2 Homo sapiens osteomyelitis|unspecified osteomyelitis nos associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001238 osteonecrosis 4 Homo sapiens osteonecrosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 GAD G 1671
GEX001239 osteoporosis 74 Homo sapiens osteoporosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 4.69984189819716 N 1.0 13-AUG-20 GAD G 1671
GEX001241 osteoporosis, postmenopausal; bone density; hormone disturbance 2 Homo sapiens osteoporosis, postmenopausal; bone density; hormone disturbance associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001244 other metabolic traits 10 Homo sapiens other metabolic traits associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 159.686068648333 N 1.0 13-AUG-20 GAD G 1671
GEX001245 otitis media 2 Homo sapiens otitis media associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001246 otosclerosis 2 Homo sapiens otosclerosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001248 ovarian cancer 26 Homo sapiens ovarian cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 311.967478478998 N 1.0 13-AUG-20 GAD G 1671
GEX001249 ovarian carcinoma 2 Homo sapiens ovarian carcinoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001250 ovarian neoplasms 8 Homo sapiens ovarian neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001251 over anticoagulation 2 Homo sapiens over anticoagulation associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001252 overall effect 20 Homo sapiens overall effect associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 399.608127779561 N 1.0 13-AUG-20 GAD G 1671
GEX001253 overfeeding 4 Homo sapiens overfeeding associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 756.782075991189 N 1.0 13-AUG-20 GAD G 1671
GEX001255 oxidative stress 8 Homo sapiens oxidative stress associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 71.5987780040733 N 1.0 13-AUG-20 GAD G 1671
GEX000780 head and neck neoplasms 5 Homo sapiens head and neck neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001227 optic nerve 4 Homo sapiens optic nerve associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001240 osteoporosis, postmenopausal 3 Homo sapiens osteoporosis, postmenopausal associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 134.16149068323 N 1.0 13-AUG-20 GAD G 1671
GEX001254 oxaliplatin 3 Homo sapiens oxaliplatin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000303 bone mineral density (hip) 13 Homo sapiens bone mineral density (hip) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 41.7457375833951 N 1.0 13-AUG-20 GAD G 1671
GEX000317 brain mapping 2 Homo sapiens brain mapping associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000795 heart rate variability traits 1 Homo sapiens heart rate variability traits associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000809 hemophilia 1 Homo sapiens hemophilia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000822 hepatitis type 2, autoimmune 2 Homo sapiens hepatitis type 2, autoimmune associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001267 pancreatitis 9 Homo sapiens pancreatitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.066116984729 N 1.0 13-AUG-20 GAD G 1671
GEX001280 parkinson's disease; alcohol abuse 2 Homo sapiens parkinson's disease; alcohol abuse associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000347 carcinoma, basal cell 5 Homo sapiens carcinoma, basal cell associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000361 cardiovascular 30 Homo sapiens cardiovascular associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 559.249973875092 N 1.0 13-AUG-20 GAD G 1671
GEX000825 hepatotoxicity leukopenia 2 Homo sapiens hepatotoxicity leukopenia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000839 hirschsprung disease 3 Homo sapiens hirschsprung disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX001292 periodontitis 47 Homo sapiens periodontitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 690.444618251282 N 1.0 13-AUG-20 GAD G 1671
GEX001306 phosphorus 19 Homo sapiens phosphorus associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000379 central nervous system 7 Homo sapiens central nervous system associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000393 cervical cancer ovarian cancer 2 Homo sapiens cervical cancer ovarian cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000862 hyperbilirubinemia 1 Homo sapiens hyperbilirubinemia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000876 hypertension; cirrhosis 2 Homo sapiens hypertension; cirrhosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000304 bone mineral density (spine) 14 Homo sapiens bone mineral density (spine) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 32.8423629067011 N 1.0 13-AUG-20 GAD G 1671
GEX000305 bone mineral mass 1 Homo sapiens bone mineral mass associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000306 bone mineralization 1 Homo sapiens bone mineralization associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000307 bone size 3 Homo sapiens bone size associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000308 brain 76 Homo sapiens brain associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000309 brain aneurysm 6 Homo sapiens brain aneurysm associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 118.760445682451 N 1.0 13-AUG-20 GAD G 1671
GEX000310 brain cancer 9 Homo sapiens brain cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 127.984153943783 N 1.0 13-AUG-20 GAD G 1671
GEX000311 brain hemorrhage 3 Homo sapiens brain hemorrhage associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000312 brain imaging 7 Homo sapiens brain imaging associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000313 brain imaging in schizophrenia (interaction) 8 Homo sapiens brain imaging in schizophrenia (interaction) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 22.9022403258656 N 1.0 13-AUG-20 GAD G 1671
GEX000314 brain infarction 2 Homo sapiens brain infarction associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000315 brain ischemia|hypertension|stroke 3 Homo sapiens brain ischemia|hypertension|stroke associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000318 brain structure 12 Homo sapiens brain structure associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000319 breast cancer 127 Homo sapiens breast cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1156.67670714448 N 1.0 13-AUG-20 GAD G 1671
GEX000320 breast cancer colorectal cancer stomach cancer 2 Homo sapiens breast cancer colorectal cancer stomach cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000321 breast cancer melanoma 2 Homo sapiens breast cancer melanoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000322 breast cancer survival 2 Homo sapiens breast cancer survival associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000324 breast cancer; insulin-like growth factor 2 Homo sapiens breast cancer; insulin-like growth factor associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000327 breast density 3 Homo sapiens breast density associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000329 bronchial asthma 2 Homo sapiens bronchial asthma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000331 bronchitis; pneumonia 3 Homo sapiens bronchitis; pneumonia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000332 bronchopulmonary aspergillosis 2 Homo sapiens bronchopulmonary aspergillosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000794 heart rate 290 Homo sapiens heart rate associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000796 heart transplant complications 4 Homo sapiens heart transplant complications associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 449.593691000629 N 1.0 13-AUG-20 GAD G 1671
GEX000797 height 183 Homo sapiens height associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.95357592384719 N 1.0 13-AUG-20 GAD G 1671
GEX000798 helicobacter infections|stomach neoplasms 2 Homo sapiens helicobacter infections|stomach neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000799 helicobacter pylori infection 3 Homo sapiens helicobacter pylori infection associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000800 hematocrit 131 Homo sapiens hematocrit associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000801 hematological parameters 12 Homo sapiens hematological parameters associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 47.4677393132914 N 1.0 13-AUG-20 GAD G 1671
GEX000387 cerebral venous thrombosis 2 Homo sapiens cerebral venous thrombosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000388 cerebrovascular disease 7 Homo sapiens cerebrovascular disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 90.6470588235294 N 1.0 13-AUG-20 GAD G 1671
GEX000389 cerebrovascular disease, ischemic 2 Homo sapiens cerebrovascular disease, ischemic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000392 cervical cancer 16 Homo sapiens cervical cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 158.070719516812 N 1.0 13-AUG-20 GAD G 1671
GEX001268 pancreatitis, acute pancreatitis, chronic 2 Homo sapiens pancreatitis, acute pancreatitis, chronic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001269 pancreatitis, autoimmune; pancreatitis, chronic calcifying 3 Homo sapiens pancreatitis, autoimmune; pancreatitis, chronic calcifying associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX001271 panic disorder 32 Homo sapiens panic disorder associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 44.7763259495448 N 1.0 13-AUG-20 GAD G 1671
GEX001272 paragangliomas, head and neck 2 Homo sapiens paragangliomas, head and neck associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001273 paragangliomas, head and neck; pheochromocytomas 2 Homo sapiens paragangliomas, head and neck; pheochromocytomas associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001274 parasitic infection 1 Homo sapiens parasitic infection associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001275 parietal lobe 12 Homo sapiens parietal lobe associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001276 parkinson disease 220 Homo sapiens parkinson disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001277 parkinson's disease 66 Homo sapiens parkinson's disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 150.696228599688 N 1.0 13-AUG-20 GAD G 1671
GEX000568 diabetes, neurological manifestations 3 Homo sapiens diabetes, neurological manifestations associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX001050 lupus nephritis 3 Homo sapiens lupus nephritis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001063 major and bipolar depressives 3 Homo sapiens major and bipolar depressives associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX001503 skin cancer, non-melanoma 1 Homo sapiens skin cancer, non-melanoma associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001518 sodium 41 Homo sapiens sodium associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000365 cardiovascular risk factors 2 Homo sapiens cardiovascular risk factors associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000366 carotid arteries 23 Homo sapiens carotid arteries associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000367 carotid artery damage 1 Homo sapiens carotid artery damage associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000368 carotid artery diseases 65 Homo sapiens carotid artery diseases associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000369 carotid artery stenosis 4 Homo sapiens carotid artery stenosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 GAD G 1671
GEX000370 carotid atherosclerosis 13 Homo sapiens carotid atherosclerosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 489.128006916685 N 1.0 13-AUG-20 GAD G 1671
GEX000371 carotid atherosclerosis in hiv infection 7 Homo sapiens carotid atherosclerosis in hiv infection associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 22.9022403258656 N 1.0 13-AUG-20 GAD G 1671
GEX000373 carvedilol pharmacokinetics 3 Homo sapiens carvedilol pharmacokinetics associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 134.16149068323 N 1.0 13-AUG-20 GAD G 1671
GEX000374 caudate nucleus 2 Homo sapiens caudate nucleus associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000375 cd14 expression 1 Homo sapiens cd14 expression associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000376 cd40 ligand 28 Homo sapiens cd40 ligand associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000378 cell adhesion molecules 75 Homo sapiens cell adhesion molecules associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000381 cerebral hemorrhage 2 Homo sapiens cerebral hemorrhage associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000382 cerebral infarct 5 Homo sapiens cerebral infarct associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 23.9931740614334 N 1.0 13-AUG-20 GAD G 1671
GEX000383 cerebral infarct, atherothrombotic 2 Homo sapiens cerebral infarct, atherothrombotic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000384 cerebral infarction 4 Homo sapiens cerebral infarction associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000385 cerebral ischemia 1 Homo sapiens cerebral ischemia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000386 cerebral malaria 4 Homo sapiens cerebral malaria associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 129.88986784141 N 1.0 13-AUG-20 GAD G 1671
GEX001149 myelopathy, htlv-1 associated 2 Homo sapiens myelopathy, htlv-1 associated associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001151 myocardial infarct stroke, ischemic 4 Homo sapiens myocardial infarct stroke, ischemic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001152 myocardial infarct; atherosclerosis 2 Homo sapiens myocardial infarct; atherosclerosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
WAG000060 Activation of BMF and translocation to mitochondria 3 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Activation%2520of%2520BMF%2520and%2520translocation%2520to%2520mitochondria&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 Reactome P 528
WAG000061 Activation of caspases through apoptosome-mediated cleavage 5 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Activation%2520of%2520caspases%2520through%2520apoptosome-mediated%2520cleavage&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 1216.80585240307 1.0 13-AUG-20 Reactome P 528
WAG000062 Apoptotic cleavage of cell adhesion proteins 10 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Apoptotic%2520cleavage%2520of%2520cell%2520adhesion%2520%2520proteins&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 828.143753032961 1.0 13-AUG-20 Reactome P 528
WAG000066 FMO oxidizes nucleophiles 3 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=FMO%2520oxidizes%2520nucleophiles&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 Reactome P 528
WAG000067 FasL/ CD95L signaling 5 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=FasL/%2520CD95L%2520signaling&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 1216.80585240307 1.0 13-AUG-20 Reactome P 528
WAG000671 Cleavage of Growing Transcript in the Termination Region 33 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Cleavage%2520of%2520Growing%2520Transcript%2520in%2520the%2520Termination%2520Region&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 11957.5413810317 1.0 13-AUG-20 Reactome P 528
WAG000672 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 59 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Cdc20:Phospho-APC/C%2520mediated%2520degradation%2520of%2520Cyclin%2520A&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 38339.3386634303 1.0 13-AUG-20 Reactome P 528
WAG000673 ChREBP activates metabolic gene expression 2 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=ChREBP%2520activates%2520metabolic%2520gene%2520expression&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 1.0 13-AUG-20 Reactome P 528
WAG000674 ARMS-mediated activation 6 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=ARMS-mediated%2520activation&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 1152.95503784362 1.0 13-AUG-20 Reactome P 528
WAG000677 Activation of C3 and C5 4 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Activation%2520of%2520C3%2520and%2520C5&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 1.0 13-AUG-20 Reactome P 528
WAG000678 Alternative complement activation 3 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Alternative%2520complement%2520activation&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 Reactome P 528
WAG000679 Exocytosis of Alpha granule 41 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Exocytosis%2520of%2520Alpha%2520granule&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 6075.135234999 1.0 13-AUG-20 Reactome P 528
WAG000681 Formation of a pool of free 40S subunits 92 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Formation%2520of%2520a%2520pool%2520of%2520free%252040S%2520subunits&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 61360.6336716561 1.0 13-AUG-20 Reactome P 528
WAG000682 G2/M Checkpoints 2 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=G2/M%2520Checkpoints&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 1.0 13-AUG-20 Reactome P 528
WAG000683 G2/M DNA replication checkpoint 2 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=G2/M%2520DNA%2520replication%2520checkpoint&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 1.0 13-AUG-20 Reactome P 528
WAG000684 GTP hydrolysis and joining of the 60S ribosomal subunit 103 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=GTP%2520hydrolysis%2520and%2520joining%2520of%2520the%252060S%2520ribosomal%2520subunit&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 69517.183631585 1.0 13-AUG-20 Reactome P 528
WAG000685 Creatine metabolism 2 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Creatine%2520metabolism&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 1.0 13-AUG-20 Reactome P 528
WAG000687 Depyrimidination 5 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Depyrimidination&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 124.19795221843 1.0 13-AUG-20 Reactome P 528
WAG000691 Mitotic Prometaphase 72 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Mitotic%2520Prometaphase&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 28755.6256214423 1.0 13-AUG-20 Reactome P 528
WAG000692 Negative regulation of the PI3K/AKT network 4 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Negative%2520regulation%2520of%2520the%2520PI3K/AKT%2520network&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 282.003028634361 1.0 13-AUG-20 Reactome P 528
WAG000693 Neurophilin interactions with VEGF and VEGFR 2 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Neurophilin%2520interactions%2520with%2520VEGF%2520and%2520VEGFR&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 126.210526315789 1.0 13-AUG-20 Reactome P 528
GEX000470 cognitive trait 8 Homo sapiens cognitive trait associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 164.246854566406 N 1.0 13-AUG-20 GAD G 1671
GEX000471 coke-oven toxicity 5 Homo sapiens coke-oven toxicity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 536.008840149947 N 1.0 13-AUG-20 GAD G 1671
GEX000474 colonic neoplasms 4 Homo sapiens colonic neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
WAG000695 Nicotinate metabolism 10 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Nicotinate%2520metabolism&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 517.136417932734 1.0 13-AUG-20 Reactome P 528
WAG000696 Orc1 removal from chromatin 55 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Orc1%2520removal%2520from%2520chromatin&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 17778.8303212662 1.0 13-AUG-20 Reactome P 528
WAG001076 AKT phosphorylates targets in the nucleus 4 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=AKT%2520phosphorylates%2520targets%2520in%2520the%2520nucleus&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 129.88986784141 1.0 13-AUG-20 Reactome P 528
WAG001077 Apoptotic cleavage of cellular proteins 14 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Apoptotic%2520cleavage%2520of%2520cellular%2520proteins&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 597.379383580853 1.0 13-AUG-20 Reactome P 528
GEX000475 colony-forming units assay 2 Homo sapiens colony-forming units assay associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000476 colorectal adenocarcinomas 2 Homo sapiens colorectal adenocarcinomas associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000477 colorectal adenomas 2 Homo sapiens colorectal adenomas associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000478 colorectal cancer 98 Homo sapiens colorectal cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 819.283357454467 N 1.0 13-AUG-20 GAD G 1671
GEX000479 colorectal cancer stomach cancer 2 Homo sapiens colorectal cancer stomach cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000480 colorectal cancer; drug hypersensitivity 2 Homo sapiens colorectal cancer; drug hypersensitivity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000481 colorectal cancer; endometrial cancer 3 Homo sapiens colorectal cancer; endometrial cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000482 colorectal carcinomas 1 Homo sapiens colorectal carcinomas associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000483 colorectal neoplasms 14 Homo sapiens colorectal neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 9.3081452404318 N 1.0 13-AUG-20 GAD G 1671
GEX000947 iron 270 Homo sapiens iron associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000948 iron levels 3 Homo sapiens iron levels associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000949 iron-regulatory proteins 3 Homo sapiens iron-regulatory proteins associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000950 irritable bowel syndrome 5 Homo sapiens irritable bowel syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 53.7883959044369 N 1.0 13-AUG-20 GAD G 1671
GEX000952 isoxazoles 6 Homo sapiens isoxazoles associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000953 jaw abnormalities 4 Homo sapiens jaw abnormalities associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
WAG000486 Mineralocorticoid biosynthesis 3 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Mineralocorticoid%2520biosynthesis&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 134.16149068323 1.0 13-AUG-20 Reactome P 528
WAG000487 NADE modulates death signalling 2 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=NADE%2520modulates%2520death%2520signalling&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 384.396541225186 1.0 13-AUG-20 Reactome P 528
GEX000486 cone degeneration 2 Homo sapiens cone degeneration associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000487 congenital adrenal hyperplasia 1 Homo sapiens congenital adrenal hyperplasia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000488 congenital anomalies; renal disease 2 Homo sapiens congenital anomalies; renal disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000489 congenital bilateral absence of the vas deferens 1 Homo sapiens congenital bilateral absence of the vas deferens associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000490 congestive heart failure 3 Homo sapiens congestive heart failure associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000491 constipation|dyspepsia|gastrointestinal diseases|irritable bowel syndrome 5 Homo sapiens constipation|dyspepsia|gastrointestinal diseases|irritable bowel syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000494 cornea 8 Homo sapiens cornea associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000495 corneal topography 2 Homo sapiens corneal topography associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000496 coronary artery calcification 2 Homo sapiens coronary artery calcification associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000498 coronary artery disease|hypertension|myocardial infarction|stroke 2 Homo sapiens coronary artery disease|hypertension|myocardial infarction|stroke associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000499 coronary artery ectasia 2 Homo sapiens coronary artery ectasia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000500 coronary artery luminal dimensions 2 Homo sapiens coronary artery luminal dimensions associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000501 coronary artery spasm 3 Homo sapiens coronary artery spasm associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000502 coronary artery vasoconstriction 2 Homo sapiens coronary artery vasoconstriction associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000503 coronary atherosclerosis 5 Homo sapiens coronary atherosclerosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 298.196889162424 N 1.0 13-AUG-20 GAD G 1671
GEX000504 coronary calcification 3 Homo sapiens coronary calcification associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000505 coronary disease 144 Homo sapiens coronary disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.507224723713263 N 1.0 13-AUG-20 GAD G 1671
WAG000522 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 15 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=Synthesis%2520of%2520bile%2520acids%2520and%2520bile%2520salts%2520via%25207alpha-hydroxycholesterol&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 563.400915080873 1.0 13-AUG-20 Reactome P 528
WAG000524 TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade 12 Homo sapiens http://www.ndexbio.org/#/search?searchType=Networks&searchString=TRAF6%2520Mediated%2520Induction%2520of%2520the%2520antiviral%2520cytokine%2520IFN-alpha/beta%2520cascade&searchTermExpansion=false PAGER curation team PAGER-contact@googlegroups.com 1638.18216177369 1.0 13-AUG-20 Reactome P 528
GEX000418 cholesterol, ldl 540 Homo sapiens cholesterol, ldl associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000020 acute pancreatitis 4 Homo sapiens acute pancreatitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 449.593691000629 N 1.0 13-AUG-20 GAD G 1671
GEX000334 bronchopulmonary dysplasia 2 Homo sapiens bronchopulmonary dysplasia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000335 brucellosis 4 Homo sapiens brucellosis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 756.782075991189 N 1.0 13-AUG-20 GAD G 1671
GEX000336 brugada syndrome 1 Homo sapiens brugada syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000337 bulimia 2 Homo sapiens bulimia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000338 butyrylcholinesterase 3 Homo sapiens butyrylcholinesterase associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000339 c-reactive protein 164 Homo sapiens c-reactive protein associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.61454380748574 N 1.0 13-AUG-20 GAD G 1671
GEX000340 caffeine 10 Homo sapiens caffeine associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 6.28410914927769 N 1.0 13-AUG-20 GAD G 1671
GEX000341 calcium 104 Homo sapiens calcium associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000342 calcium-binding proteins 23 Homo sapiens calcium-binding proteins associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.92775151924375 N 1.0 13-AUG-20 GAD G 1671
GEX000343 cancer 9 Homo sapiens cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 101.265573705896 N 1.0 13-AUG-20 GAD G 1671
GEX000344 carbamazepine hypersensitivity 2 Homo sapiens carbamazepine hypersensitivity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000345 carbohydrate-deficient transferrin 4 Homo sapiens carbohydrate-deficient transferrin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.7709251101322 N 1.0 13-AUG-20 GAD G 1671
GEX000348 carcinoma, hepatocellular 6 Homo sapiens carcinoma, hepatocellular associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000349 carcinoma, hepatocellular|liver neoplasms 2 Homo sapiens carcinoma, hepatocellular|liver neoplasms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000350 carcinoma, non-small-cell lung 5 Homo sapiens carcinoma, non-small-cell lung associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000351 carcinoma, renal cell 4 Homo sapiens carcinoma, renal cell associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000353 cardiac death 5 Homo sapiens cardiac death associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 53.7883959044369 N 1.0 13-AUG-20 GAD G 1671
GEX000355 cardiac death myocardial infarct 2 Homo sapiens cardiac death myocardial infarct associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000356 cardiac structure and function 5 Homo sapiens cardiac structure and function associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000357 cardiomegaly 28 Homo sapiens cardiomegaly associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000358 cardiomyopathy 18 Homo sapiens cardiomyopathy associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 252.416974657418 N 1.0 13-AUG-20 GAD G 1671
GEX000362 cardiovascular disease 22 Homo sapiens cardiovascular disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 643.05060471316 N 1.0 13-AUG-20 GAD G 1671
GEX000364 cardiovascular diseases 60 Homo sapiens cardiovascular diseases associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.32598140910484 N 1.0 13-AUG-20 GAD G 1671
GEX000826 hepatotoxicity, diclofenac-induced 3 Homo sapiens hepatotoxicity, diclofenac-induced associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX000852 hormone disturbance 11 Homo sapiens hormone disturbance associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 147.095357472716 N 1.0 13-AUG-20 GAD G 1671
GEX000855 human papillomavirus infection 2 Homo sapiens human papillomavirus infection associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001287 pemphigus foliaceus 5 Homo sapiens pemphigus foliaceus associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 12.8588235294118 N 1.0 13-AUG-20 GAD G 1671
GEX001288 pemphigus vulgaris 2 Homo sapiens pemphigus vulgaris associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001289 pendred's syndrome 1 Homo sapiens pendred's syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001290 perceived parenting 2 Homo sapiens perceived parenting associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000394 cervical dystonia 1 Homo sapiens cervical dystonia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000857 huntington disease 2 Homo sapiens huntington disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000858 huntington's disease 2 Homo sapiens huntington's disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000860 hyperactive-impulsive symptoms 5 Homo sapiens hyperactive-impulsive symptoms associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000861 hyperandrogenism 3 Homo sapiens hyperandrogenism associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000863 hypercholesterolemia 9 Homo sapiens hypercholesterolemia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 250.385331471507 N 1.0 13-AUG-20 GAD G 1671
GEX000865 hyperlipidemia 8 Homo sapiens hyperlipidemia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1317.69807187265 N 1.0 13-AUG-20 GAD G 1671
GEX000866 hyperparathyroidism 3 Homo sapiens hyperparathyroidism associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000867 hypersensitivity, immediate 2 Homo sapiens hypersensitivity, immediate associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000868 hypertension 237 Homo sapiens hypertension associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 55.5340886456037 N 1.0 13-AUG-20 GAD G 1671
GEX000869 hypertension (young onset) 3 Homo sapiens hypertension (young onset) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000870 hypertension, pregnancy induced 6 Homo sapiens hypertension, pregnancy induced associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 135.910779100194 N 1.0 13-AUG-20 GAD G 1671
GEX000871 hypertension, pregnancy induced preeclampsia 3 Homo sapiens hypertension, pregnancy induced preeclampsia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 384.396541225186 N 1.0 13-AUG-20 GAD G 1671
GEX000872 hypertension, pulmonary arterial 2 Homo sapiens hypertension, pulmonary arterial associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000873 hypertension/complications* 7 Homo sapiens hypertension/complications* associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 355.796236240975 N 1.0 13-AUG-20 GAD G 1671
GEX000874 hypertension; blood pressure 1 Homo sapiens hypertension; blood pressure associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000875 hypertension; cardiovascular disease 2 Homo sapiens hypertension; cardiovascular disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000877 hypertension|obesity 2 Homo sapiens hypertension|obesity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000878 hypertriglyceridemia 9 Homo sapiens hypertriglyceridemia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 453.626329836873 N 1.0 13-AUG-20 GAD G 1671
GEX000879 hypertrophic cardiomyopathy 2 Homo sapiens hypertrophic cardiomyopathy associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000880 hypertrophy, left ventricular 90 Homo sapiens hypertrophy, left ventricular associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000881 hypoglycemia 1 Homo sapiens hypoglycemia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000882 hypospadias 5 Homo sapiens hypospadias associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001291 periodontal disease 5 Homo sapiens periodontal disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 340.449448889386 N 1.0 13-AUG-20 GAD G 1671
GEX001293 periodontitis, early-onset 2 Homo sapiens periodontitis, early-onset associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001294 peripheral vascular disease 3 Homo sapiens peripheral vascular disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GAD G 1671
GEX001295 peroxidase 17 Homo sapiens peroxidase associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001296 perphenazine 10 Homo sapiens perphenazine associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001298 personality dimensions 4 Homo sapiens personality dimensions associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001301 peutz-jeghers syndrome 1 Homo sapiens peutz-jeghers syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001302 phenprocoumon requirements 2 Homo sapiens phenprocoumon requirements associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001303 phenytoin 2 Homo sapiens phenytoin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001304 phosphatidylcholines 4 Homo sapiens phosphatidylcholines associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001307 physical function 2 Homo sapiens physical function associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001308 phytosterols 2 Homo sapiens phytosterols associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001311 pituitary cancer 2 Homo sapiens pituitary cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001312 placental abruption 2 Homo sapiens placental abruption associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001313 plasma c4b binding protein levels 1 Homo sapiens plasma c4b binding protein levels associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001314 plasma carotenoid and tocopherol levels 1 Homo sapiens plasma carotenoid and tocopherol levels associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001316 plasma coagulation factors 1 Homo sapiens plasma coagulation factors associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001317 plasma eosinophil count 7 Homo sapiens plasma eosinophil count associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 9.91853360488798 N 1.0 13-AUG-20 GAD G 1671
GEX000493 copd severity 1 Homo sapiens copd severity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000506 coronary disease|diabetes complications|hypercholesterolemia|hypertension|myocardial infarction 2 Homo sapiens coronary disease|diabetes complications|hypercholesterolemia|hypertension|myocardial infarction associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX000990 leukemia, acute myeloid 2 Homo sapiens leukemia, acute myeloid associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001004 lipid metabolism 16 Homo sapiens lipid metabolism associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 129.163575427505 N 1.0 13-AUG-20 GAD G 1671
GEX001446 rheumatic fever 2 Homo sapiens rheumatic fever associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001459 schizophrenia 299 Homo sapiens schizophrenia associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 34.6284373663467 N 1.0 13-AUG-20 GAD G 1671
GEX000036 age-related skeletal disorders 1 Homo sapiens age-related skeletal disorders associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000051 alcohol abuse cirrhosis, alcoholic pancreatitis, chronic 3 Homo sapiens alcohol abuse cirrhosis, alcoholic pancreatitis, chronic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 134.16149068323 N 1.0 13-AUG-20 GAD G 1671
GEX000525 crohn's disease; ulcerative colitis 16 Homo sapiens crohn's disease; ulcerative colitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 595.460860857273 N 1.0 13-AUG-20 GAD G 1671
GEX000540 dance performance 2 Homo sapiens dance performance associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001017 liver cancer 11 Homo sapiens liver cancer associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 335.724458471302 N 1.0 13-AUG-20 GAD G 1671
GEX001030 lumbar disc disease 2 Homo sapiens lumbar disc disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001477 sepsis; systemic inflammatory response syndrome 2 Homo sapiens sepsis; systemic inflammatory response syndrome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001493 severe rsv bronchiolitis 1 Homo sapiens severe rsv bronchiolitis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX000072 allograft outcome 4 Homo sapiens allograft outcome associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 756.782075991189 N 1.0 13-AUG-20 GAD G 1671
WAG000846 proteasome complex 24 Homo sapiens Attachment of the ubiquitin peptide to proteins targets them for proteolytic degradation by a complex cellular structure, the proteasome. The regulated proteolysis of proteins by proteasomes removes detured, damaged or improperly translated proteins from cells and regulates the level of proteins like cyclins or some transcription factors. E1 and E2 enzymes prepare ubiquitin chains that are then attached to proteins by the E3 enzyme. The sequence of ubiquitin and the basic structure and function of the proteasome are highly conserved. The core proteasome in man (20S proteasome) consists of four rings each with 14 subunits stacked on top of each other that are responsible for the proteolytic activity of the proteasome. The PA700 regulatory complex is stacked on the ends of the cylindrical core to form a 26S proteasome. Proteins that are tagged with ubiquitin are recognized and bound by the regulatory subunits, then unfolded in an ATP-dependent manner, and inserted into the core particle, where proteases degrade the protein, releasing small peptides and releasing the ubiquitin intact. The PA28 regulatory complex is altertive regulatory complex that appears to play a role in antigen processing for presentation of peptides to immune cells in the MHC I complex. https://cgap.nci.nih.gov/Pathways/BioCarta/ PAGER curation team PAGER-contact@googlegroups.com 8631.39279429721 1.0 13-AUG-20 BioCarta P 252
WAG000847 protein kinase a at the centrosome 10 Homo sapiens Protein kise A regulatory subunit RIIalpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-kise anchoring protein AKAP350 (also known as AKAP450 and CGP), MAP2 and Pericentrin. This diagram illustrates these three PKA-RII binding complexes. The cyclin B-p34(cdc2) kise (CDK1) has been shown to phosphorylate PKA-RIIa on T54 and this has been proposed to alter the subcellular localization of PKA-RIIa at the on set of mitosis. It has been demonstrated that PKA-RIIa dissociates and redistributes from centrosomes at mitosis. The focal point of this illustration is the AKAP350 complex. In addition to binding PKA-RIIa, AKAP350 binds PKN (Takahashi et al 1999) and the phosphatases PP1 and PPA2 (Takahashi et al 1999). PKN is a serine/threonine protein kise, having a catalytic domain homologous to the PKC family in the C-termil region and a unique regulatory region in the N-termil region. PKN is activated by a small GTPase RhoA and unsaturated fatty acids such as arachidonic acid. The binding of both kises and phophatases by the same scaffold protein provides a focal point where physiological events, such as cell cycle progression and intracellular membrane traffic, may be regulated by phosphorylation state of specific protein substrates. There are at least 4 isoforms of AKAP350 which lead to the possibility that they may behave differently at different subcellular locations. MAP2 is a member of a group of proteins that provide microtubule stabilization. MAP2 affinity appears to be dependent on PKA phosphorylation of MAP2. Pericentrin is also an AKAP (Diviani and Scott). Pericentrin binds Dynein which is also regulated by PKA leading to the possibility that pericentrin positions PKA to regulate dynein function (Diviani and Scott). Another example of AKAP/PKA interaction is illustrated in the AKAP95 role in mitosis and chromosome dymics?pathway. https://cgap.nci.nih.gov/Pathways/BioCarta/h_akapCentrosomePathway PAGER curation team PAGER-contact@googlegroups.com 1286.54166588129 1.0 13-AUG-20 BioCarta P 252
WAG000016 rho-selective guanine exchange factor akap13 mediates stress fiber formation 8 Homo sapiens The A-kise anchor protein 13 (AKAP13, also known as AKAP-LBC) is one of a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kise A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP13 is a splice variant of the oncogene Lbc. Altertive splicing of the AKAP13 gene results in at least 3 transcript variants encoding different isoforms containing a Dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the ictive GTPase to the active form capable of transducing sigls. The PH domain has multiple functions. These splice variants contain a fragment that was origilly identified as Ht31 (See Carr et al 1991) which acts as a scaffolding protein to regulate the Rho sigling pathway and as protein kise A-anchoring protein creating a coordition of these two siglling pathways. https://cgap.nci.nih.gov/Pathways/BioCarta/h_akap13Pathway PAGER curation team PAGER-contact@googlegroups.com 1159.6882034516 1.0 13-AUG-20 BioCarta P 252
WAG000017 btg family proteins and cell cycle regulation 9 Homo sapiens BTG2 is found to be one of the immediate early genes up-regulated by neural growth factor (NGF) and epidermal growth factor (EGF). Its transcriptiol level is also up-regulated by p53, gamma radiation, adriamycin and UV treatment of cells. BTG seems to be important for the cell cycle progression as BTG2 is preferentially expressed in quiescent cells. Over-expression of BTG2 decreases the growth of NIH3T3 cells and induces neurol differentiation and prevention apoptosis of PC12 cells. Molecularly, BTG2 expression induces hypophosphorylation of RB and G1 arrest which could be rescued by overexpression of cyclin D1. BTG1 and BTG2 interact with PRMT1 (predomint cellular arginine N-methyltransferase) and increase PRMT1 methyltransferase activity. Box C domain in BTG1 and 2 are responsible for the interaction. Box C domain alone acts as a domint negative which blocks PRMT1 activity. PRMT1 activity is essential for NGF induced PC12 differentiation, and blocking PRMT1 by Box C domain of BTG1 or 2 induces apoptosis. In addition, BTG2 and HoxB9 interaction enhances the transcription of Hoxb9. Lastly, association of BTG2 and BTG1 with Caf1 is also reported to modulates transcriptiol activity of CAF1. https://cgap.nci.nih.gov/Pathways/BioCarta/h_btg2Pathway PAGER curation team PAGER-contact@googlegroups.com 708.943007439916 1.0 13-AUG-20 BioCarta P 252
WAG000018 classical complement pathway 13 Homo sapiens The complement system is part of the defense against invading cells and is composed of about twenty different proteins found in the plasma. When activated, complement proteins form a pathway of proteolytic reactions that culmites in the lysis of foreign cells. The complement system also stimulates phagocytosis of foreign cells and an inflammatory response. There are two different complement systems, the classical complement pathway initiated by antibody complexes on the cell surface, and an altertive complement pathway that is initiated without antibodies. https://cgap.nci.nih.gov/Pathways/BioCarta/h_classicPathway PAGER curation team PAGER-contact@googlegroups.com 2204.4844073089 1.0 13-AUG-20 BioCarta P 252
GEX001396 radiation sensitivity 2 Homo sapiens radiation sensitivity associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001397 radiographically evident osteoarthritis 2 Homo sapiens radiographically evident osteoarthritis associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001398 radiotherapy 2 Homo sapiens radiotherapy associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001400 rate of decline in lung function in smokers 2 Homo sapiens rate of decline in lung function in smokers associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GAD G 1671
GEX001401 receptors, interleukin-6 2 Homo sapiens receptors, interleukin-6 associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001402 receptors, transferrin 2 Homo sapiens receptors, transferrin associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001403 receptors, tumor necrosis factor 15 Homo sapiens receptors, tumor necrosis factor associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.93452844894778 N 1.0 13-AUG-20 GAD G 1671
GEX001404 receptors, tumor necrosis factor, type ii 24 Homo sapiens receptors, tumor necrosis factor, type ii associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.11174785100287 N 1.0 13-AUG-20 GAD G 1671
GEX001405 recombination rate (females) 2 Homo sapiens recombination rate (females) associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001407 recombination, genetic 1 Homo sapiens recombination, genetic associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GAD G 1671
GEX001174 nephropathy 19 Homo sapiens nephropathy associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 267.880574280326 N 1.0 13-AUG-20 GAD G 1671
GEX001300 personality traits 10 Homo sapiens personality traits associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 470.335800141849 N 1.0 13-AUG-20 GAD G 1671
GEX000225 behcet's disease 11 Homo sapiens behcet's disease associated genes. PAGER constructed this gene set by grouping all genes which are associated with the same broad phenotype (disease) on GAD. http://geneticassociationdb.nih.gov/ PAGER curation team PAGER-contact@googlegroups.com CURRENT 114.572879950238 N 1.0 13-AUG-20 GAD G 1671
FEX001595 Leukemia Murati09 1686genes 1027 Homo sapiens SuppTable 2 Expression signature (1 686 discriminator genes) between the MYST3-linked subgroup and the M4/M5 AMLs subgroup https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18818702-SuppTable2 18818702.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 4.47641522571482 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001751 Liver Skawran08 62genes 51 Homo sapiens Table 3. SAM in regard to histological grading and in regard to loss of 13q; Upregulated genes are mainly involved in cell-cycle control and proliferation in particular six genes (TOP2A BIC RFC4 RBPMS RPSA and CPNE1) found upregulated for both parameters https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18820673-Table3 18820673.0 Liver PAGER curation team PAGER-contact@googlegroups.com CURRENT 108.397911755475 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001952 Lung Chitale09 25genes KRAS 18 Homo sapiens Table 1b. KRAS expression profiles https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19525976-Table1b 19525976.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.54633061527057 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002678 Prostate Alonso09 16genes 14 Homo sapiens Table 1. Mean comparisons for relative expression levels of the 14 genes in cDNA arrays. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19026495-table1 19026495.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 158.652287306618 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003463 Viral Gao08 5genes 4 Homo sapiens Table 1 Name and function of genes selected https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18317805-Table1 18317805.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 756.782075991189 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003234 Stomach Galamb08 24genes 16 Homo sapiens Table 2a Genes differentially expressed (RMA and MAS 5 overlaps) between the subgroups https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18321301-Table2a 18321301.0 Stomach PAGER curation team PAGER-contact@googlegroups.com CURRENT 69.309570161298 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000766 Breast Aar?e10 48genes 20 Homo sapiens Additional file 6 - Interaction confidence predicted by HEFalMp/Graphle between the core genes in each group (z-score https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20078854-TableS6a 20078854.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 112.387713114571 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002504 Breast Nagaraja10 1345genes 962 Homo sapiens Supplementary Table: up in clear cell (1345) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20081105-ST-1 20081105.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 206.991607692674 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002505 Breast Nagaraja10 3054genes 2170 Homo sapiens Supplementary Table: down in clear cell (1709) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20081105-ST-2 20081105.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 34.1584852902667 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001754 Liver Sakai08 81genes 78 Homo sapiens Table 1. Biological processes for genes up-regulated in HCC-infiltrating mononuclear inflammatory cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19074895-Table1 19074895.0 Liver PAGER curation team PAGER-contact@googlegroups.com CURRENT 214.399524070539 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001755 Liver Sakai08 86genes 79 Homo sapiens Table 3. Biological processes for genes up-regulated in PBMCs of HCC patients https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19074895-Table3 19074895.0 Liver PAGER curation team PAGER-contact@googlegroups.com CURRENT 383.27969746839 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003111 StemCell Kocer08 575genes 492 Homo sapiens Table S9. List of the genes that are differentially expressed in at least one array 2 fold in either 6+/MHCI+ cells or 6+/MHCI- cells and are consistently upregulated or down regulated in both arrays https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18667080-TableS9 18667080.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 285.253133529226 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000940 Colon Jorissen08 829genes 621 Homo sapiens Supplementary Table 2: The 829 and 192 genes (probesets) consistently changed between MSI and MSS cases across multiple studies of primary CRCs and across primary CRCs and CRC cell lines respectively. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19088021-supptable2 19088021.0 Colon PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.67383614238518 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000941 Colon Jorissen08 20genes 15 Homo sapiens Consistent MSI-associated candidate genes identified by at least two Affymetrix probe sets and one IMAGE clone https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19088021-Table4 19088021.0 Colon PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.47263249348393 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001562 Leukemia San Jose-Eneriz08 730genes 589 Homo sapiens TableS4 Total analysis of genes differently expressed between CD34+ cells of CML patients before and after 24 hours https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18537972-TableS4 18537972.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 9.02559555837894 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000034 Bladder Ewis06 38genes 29 Homo sapiens Table 1: Genes differentially up-regulated in SCC of the bladder compared to normal urothelium https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17349526-Table1 17349526.0 Bladder PAGER curation team PAGER-contact@googlegroups.com CURRENT 130.775860090495 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000035 Bladder Ewis06 44genes 33 Homo sapiens Table 2: Genes differentially down-regulated in SCC of the bladder compared to normal urothelium https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17349526-Table2 17349526.0 Bladder PAGER curation team PAGER-contact@googlegroups.com CURRENT 41.0482197110745 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002552 pancreas Jimeno07 39genes 33 Homo sapiens Table 2.Variation in expression of selected relevant genes in resistant versus susceptible and of intermediate susceptibility cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17363501-Table2 17363501.0 Pancreas PAGER curation team PAGER-contact@googlegroups.com CURRENT 450.111234763634 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000817 Cervical Lau07 60genes 59 Homo sapiens Table 1. Affymetrix GeneChip analysis of expression changes in UV-induced apoptosis related genes in cells treated with p16 siRNA compared to control siRNA https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17369842-Table1 17369842.0 Cervical PAGER curation team PAGER-contact@googlegroups.com CURRENT 759.244199096496 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000493 Breast Turashvili07 82genes 68 Homo sapiens Differentially expressed probe sets between normal ductal (D) and normal lobular (L) cells found by both rank products and pairwise analysis. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17389037-Tab1 17389037.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.440830104861471 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000494 Breast Turashvili07 326genes 225 Homo sapiens Differentially expressed probe sets between ductal carcinoma (Tduc) and normal ductal (D) cells found by both rank products and pairwise analysis. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17389037-Tab2 17389037.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 32.1804968145608 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000495 Breast Turashvili07 171genes 134 Homo sapiens Differentially expressed probe sets between ductal carcinoma (Tduc) and normal lobular (L) cells found by both rank products and pairwise analysis. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17389037-Tab3 17389037.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 54.2562518738605 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000496 Breast Turashvili07 32genes 25 Homo sapiens Differentially expressed probe sets between ductal (Tduc) and lobular carcinoma (Tlob) cells found by both rank products and pairwise analysis. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17389037-Tab4 17389037.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.841768779968034 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000497 Breast Turashvili07 201genes 158 Homo sapiens Differentially expressed probe sets between lobular carcinoma (Tlob) and normal ductal (D) cells found by both rank products and pairwise analysis. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17389037-Tab5 17389037.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 71.2265434303882 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000912 Colon Bandres07 8genes 6 Homo sapiens Table II. Signature gene-set differentially expressed between patients with different prognosis. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17390049-Table2 17390049.0 Colon PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000499 Breast Gruvberger-Saal07 50genes 27 Homo sapiens \Gene expressed in ERbeta positive patients after adjuvant tamoxifen treatment\\\ https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17404078-GeneList 17404078.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.841768779968034 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000500 Breast Ma07 28genes recurrence 20 Homo sapiens Table 1. The 28-gene signature for breast cancer recurrent and metastatic potential https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17404081-Table1 17404081.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 7.33506300963677 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000516 Breast Mackay07 1264GenesDownRegulated 929 Homo sapiens Table 1. Genes Down-regulated by AI Treatment https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17555561-Table1 17555561.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 13.2054169181354 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000517 Breast Mackay07 1395GenesUpRegulated 1130 Homo sapiens Table 2. Genes Up-regulated by AI Treatment https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17555561-Table2 17555561.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 11.5759607690783 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003439 Viral Chen07 60genes 40 Homo sapiens Supplemental Table 1: HCV Unique Genes categorized according to function revealed that HCV structural or NS proteins affected cell regulation which includes processes such as proliferation and apoptosis and also immune response and host defense genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17404395-TableS1c 17404395.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 31.1192905269018 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001372 Leukemia Gebauer05 20genes PHCCells 20 Homo sapiens Table 2b.Table showing the 20 most strongly expressed genes in PHC. The genes were ranked by the mean of normalized expression levels (??int??: intensity) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15950496-Table2b 15950496.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 965.503477316492 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001373 Leukemia Gebauer05 19genes 19 Homo sapiens Table 3a. Genes which are significantly regulated by stimulation with 1 ng/ml IL-1Beta in SW1353 cells (a) and PHCs in vitro; 312 investigated genes IL-1beta significantly up-regulated 11 genes and significantly downregulated eight genes in SW1353 cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15950496-Table3a 15950496.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 235.181142136328 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001374 Leukemia Gebauer05 34genes 34 Homo sapiens Table 3b. Genes which are significantly regulated by stimulation with 1 ng/ml IL-1Beta in SW1353 cells (b; the values for MMP-3 were beyond the linear range of the measurement and were therefore not included in b). Given are the ratios IL-1beta-stimulated vs controls. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15950496-Table3b 15950496.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 623.101899244836 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002577 Placenta Heikkila05 9genes 3 Homo sapiens Table 4. Selected up-regulated genes related to immunology functions https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15954879-Table4 15954879.0 Placenta PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.7204968944099 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002578 Placenta Heikkila05 10genes 4 Homo sapiens Table 6. Selected unclassified up-regulated genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15954879-Table6 15954879.0 Placenta PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002852 StemCell Komor05 21genes ErythropoieticDifferentiation 21 Homo sapiens SuppTable 1. Genes continuously regulated during erythropoietic differentiation with continuously increasing expression https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15955831-SuppTable1 15955831.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 10.3880856371275 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002853 StemCell Komor05 58genes 46 Homo sapiens SuppTable 2. Genes continuously regulated during erythropoietic differentiation with continuously decreasing expression https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15955831-SuppTable2 15955831.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 3.66863033873343 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002854 StemCell Komor05 21genes GranulopoieticDifferentiation 20 Homo sapiens SuppTable 3. Genes continuously regulated during granulopoietic differentiation with continuously increasing expression https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15955831-SuppTable3 15955831.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 27.2798129384256 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002855 StemCell Komor05 30genes 24 Homo sapiens SuppTable 4. Genes continuously regulated during granulopoietic differentiation with continuously decreasing expression https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15955831-SuppTable4 15955831.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 7.16200350920535 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002856 StemCell Komor05 91genes 80 Homo sapiens SuppTable 5. Genes continuously regulated during megakaryopoietic differentiation with continuously increasing expression https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15955831-SuppTable5 15955831.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 12.8753267070097 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002858 StemCell Komor05 39genes 37 Homo sapiens Table 4. Genes differentially expressed in erythropoiesis https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15955831-Table4 15955831.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 44.468279497842 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001833 Lung Wang05 64genes 56 Homo sapiens TABLE I. Transcripts of human growth factor expressed by human mast cells in a highly pure population of in vitro derived human cord bloodderived mast cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15696083-Table1 15696083.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 802.209848858182 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001330 Leukemia Karawajew05 20genes 19 Homo sapiens Table 1. Stress- and oligomycin-induced changes of gene expression in MOLT-3 cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15705792-Table1 15705792.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 267.338635105392 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001036 Esophagus Helm05 40genes 33 Homo sapiens Table 3. Candidate gene predictors of progression to adenocarcinoma in Barrett https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15814623-Table3 15814623.0 Esophagus PAGER curation team PAGER-contact@googlegroups.com CURRENT 8.94879927503398 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000015 Bladder Takata05 50genes 45 Homo sapiens Table 3. List of 50 discriminating genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15814643-Table3 15814643.0 Bladder PAGER curation team PAGER-contact@googlegroups.com CURRENT 9.3390749561239 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001340 Leukemia Janssen05 33genes 25 Homo sapiens Table 3. List of differentially expressed genes in index patient and level of differential expression https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15815727-Table3 15815727.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 59.4628641184142 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001341 Leukemia Falt05 50genes DownRegulatedVH3 48 Homo sapiens Table S1a. Genes down-regulated in VH3-21+ B-CLL https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15817677-TableS1a 15817677.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 12.1046179473262 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001342 Leukemia Falt05 50genes UpRegulatedVH3 43 Homo sapiens Table S1b. Genes up-regulated in VH3-21+ B-CLL https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15817677-TableS1b 15817677.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 17.0146727289831 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001344 Leukemia Falt05 50genes UpRegulatedLgUnmutatedNon-VH3 47 Homo sapiens Table S2b. Genes upregulated in Ig-unmutated non-VH3-21 B-CLL https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15817677-TableS2b 15817677.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 14.3545997905973 N 1.0 13-AUG-20 GeneSigDB G 2942
WAG000019 the 41bb-dependent immune response 11 Homo sapiens The activation of T cells requires a co-stimulatory sigl with T cell receptor activation, provided in many cases by activation of CD28 in resting T cells. 4-1BB (CD137) is a member of the TNF receptor gene family that provides another T cell co-stimulatory sigl. 4-1BB is expressed by activated cytotoxic and helper T cells and its expression is induced by a variety of T cell stimuli, including activation of the T cell receptor or stimulation with mitogens. The ligand for 4-1BB (4-1BBL) is induced on activated antigen-presenting cells including macrophages, activating T cells expressing 4-1BB. Mice lacking 4-1BB survive and have an altered though functiol immune response. T cells of mice lacking 4-1BB proliferate more rapidly than normal T cells, but have reduced cytokine secretion. The costimulatory sigl provided by 4-1BB may act in combition with CD28 activation to prolong the T cell response, and may also act independently of CD28. Stimulation of T cells with the 4-1BB ligand may provide a therapeutic immune response in the treatment of cancer or viral infection. https://cgap.nci.nih.gov/Pathways/BioCarta/h_41bbPathway PAGER curation team PAGER-contact@googlegroups.com 983.951520177935 1.0 13-AUG-20 BioCarta P 252
WAG000020 downregulated of mta-3 in er-negative breast tumors 11 Homo sapiens Approximately 30% of breast carcinomas lack ER expression. Presumably, these breast cancers become estrogen independent through genetic alterations that bypass the requirement for ER-dependent stimulation of cell proliferation. As such estrogen receptor is a key regulator of proliferation and differentiation in mammary epithelia and represents a crucial prognostic indicator and therapeutic target in breast cancer. Mechanistically, estrogen receptor induces changes in gene expression through direct gene activation of a number of genes (cathepsin D, HSP27 (heat shock protein 27,000 kDa, aldolase A, dehydrogese, alpha-tubulin, and glyceraldehyde-3-phosphat, Pdzk1, Greb ets) and also through the biological functions of target loci. The product of human MTA3 has been identified as an estrogen-dependent component of the Mi-2/NuRD transcriptiol corepressor in breast epithelial cells and demonstrate that MTA3 constitutes a key component of an estrogen-dependent pathway regulating growth and differentiation. The absence of estrogen receptor or of MTA3 leads to aberrant expression of the transcriptiol repressor Sil, a master regulator of epithelial to mesenchymal transitions. Aberrant Sil expression results in loss of expression of the cell adhesion molecule E-cadherin, an event associated with changes in epithelial architecture and invasive growth. MTA3 is the mechanistic link between estrogen receptor status and invasive growth of breast cancers. https://cgap.nci.nih.gov/Pathways/BioCarta/h_mta3Pathway PAGER curation team PAGER-contact@googlegroups.com 429.335381599532 1.0 13-AUG-20 BioCarta P 252
WAG000215 regulation of bad phosphorylation 22 Homo sapiens The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway . BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kise A inhibitors. https://cgap.nci.nih.gov/Pathways/BioCarta/h_badPathway PAGER curation team PAGER-contact@googlegroups.com 1353.85696856752 1.0 13-AUG-20 BioCarta P 252
WAG000425 il-10 anti-inflammatory signaling pathway 11 Homo sapiens IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by activated macrophages. The IL-10 receptor is in the JAK/STAT class of receptors but activation of the JAK/STAT pathways by IL-10 does not appear on its own to be responsible for the anti-inflammatory properties of this cytokine. The anti-inflammatory actions of IL-10 appear to require induction of the enzyme heme oxygese-1 (HO-1) through a map kise pathway involving the p38 kises. HO-1 is involved in the biosynthesis of heme, and catalyzes a reaction producing carbon monoxide, free iron, and the heme precursor biliverdin. HO-1 is induced by IL-10 and is also induced by oxidative stress. Blocking HO-1 with inhibitors or antisense blocks the anti-inflammatory actions of IL-10. The anti-inflammatory actions of HO-1 appear to be the result of sigling by carbon monoxide it produces since removal of CO blocks the anti-inflammatory action of IL-10 and HO-1. The anti-inflammatory actions of IL-10 may be therapeutically useful either directly or through modulation of HO-1 activity. https://cgap.nci.nih.gov/Pathways/BioCarta/h_il10Pathway PAGER curation team PAGER-contact@googlegroups.com 1364.53207170188 1.0 13-AUG-20 BioCarta P 252
WAG000211 sprouty regulation of tyrosine kinase signals 16 Homo sapiens Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors, including EGF and FGF. One mechanism by which Sprouty proteins inhibit sigling is through binding to Grb-2, a sigling intermediary between the tyrosine kise growth factors and the Ras/map kise pathway. Binding of Sprouty to Grb-2 prevents Grb-2 and Sos-1 from interacting with downstream sigling factors that activate Ras and map kises, including Ras, Raf-1, Mek1, Erk1/2 and downstream transcription factors. The action of Sprouty as an inhibitor of this pathway requires Sprouty phosphorylation and membrane localization, at the site of the factors it interacts with. The inhibition of growth factor sigling by Sprouty is specific to the Ras pathway since the PI3 Kise pathway responsible for cell survival sigls from growth factor receptors is not inhibited by Sprouty. Tyrosine kise activity of growth factor receptors is also not affected. The mechanism by which Sprouty inhibits Ras activation may be by blocking the nucleotide exchange activity of Sos. Sprouty expression is induced by growth factor receptor activation of Ras sigling, provided a self-regulatory feedback inhibition mechanism that regulates growth factor sigling through Ras. https://cgap.nci.nih.gov/Pathways/BioCarta/h_spryPathway PAGER curation team PAGER-contact@googlegroups.com 4009.66853120453 1.0 13-AUG-20 BioCarta P 252
FEX002506 Breast Nagaraja10 14genes 11 Homo sapiens Table 2. All mir-100 predicted target genes that were overexpressed in clear cell ovarian cancer https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20081105-Table2 20081105.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 12.2278664731495 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002507 Breast Nagaraja10 27genes 22 Homo sapiens Table 3. All mir-22 predicted target genes that were overexpressed in clear cell ovarian cancer https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20081105-Table3 20081105.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002509 Breast Nagaraja10 25genes mir-30aKnockdown 24 Homo sapiens Table 5. Top 25 mir-30a predicted target genes that were underexpressed in clear cell ovarian cancer and up-regulated after mir-30a knockdown https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20081105-Table5 20081105.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.4631122132672 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002353 Lymphoma Sagaert10 167genes 96 Homo sapiens Table 3 Chromosomal regions with differential expression composing the gastric MALT lymphoma signature and relevant genes mapped to these regions https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20081812-Table3 20081812.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 492.367711036497 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002354 Lymphoma Sagaert10 38genes 27 Homo sapiens Table 4 Chromosomal regions with differential expression composing the marginal zone signature and relevant genes mapped to these regions https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20081812-Table4 20081812.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 1575.63846517138 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002355 Lymphoma Zhao10 18genes 17 Homo sapiens Table 2a. Down-regulated (at least 1.5 fold change) miRNAs in Mantle Cell Lymphoma https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20086245-Table2a 20086245.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002356 Lymphoma Zhao10 21genes 20 Homo sapiens Table 2b. Up-regulated (at least 1.5 fold change) miRNAs in Mantle Cell Lymphoma https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20086245-Table2b 20086245.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000768 Breast Buffa10 51genes Hypoxia 46 Homo sapiens Table S5. Common Hypoxia Signature Genes ranked by the Common Connectivity Score (from highest to lowest) and their expression changes in cell lines experiments of hypoxia exposure and HIF1a siRNA https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20087356-TableS5 20087356.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 129.102567352966 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002777 Skin Dry10 269genes 176 Homo sapiens Table S3. Probeset centric RMA normalized Affymetrix expression data is shown for the 180 prioritized genes across the mixed-tumor and melanoma cell panels. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20215513-TableS3 20215513.0 Skin PAGER curation team PAGER-contact@googlegroups.com CURRENT 18.254706191054 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002778 Skin Dry10 181genes 176 Homo sapiens Table S4. 180 genes prioritized as markers of cell line response to AZD6244 following complementary statistical and biological filtering. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20215513-TableS4 20215513.0 Skin PAGER curation team PAGER-contact@googlegroups.com CURRENT 18.254706191054 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003235 Stomach Galamb08 36genes 26 Homo sapiens Table 2b Genes differentially expressed (RMA and MAS 5 overlaps) between the subgroups https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18321301-Table2b 18321301.0 Stomach PAGER curation team PAGER-contact@googlegroups.com CURRENT 48.721699363198 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003153 StemCell Novakova10 21genes 14 Homo sapiens Table 2. List of cytokines with transcripts upregulated by 10??m BrdU+DMA https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19802007-Table2 19802007.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 366.38298358533 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003154 StemCell Hassan09 1544genes 1040 Homo sapiens Supplementary Table 3. Gene list mapped to the Affymetrix Human Genome U133A focusing on gene sets ES exp1 PRC2 targets NOS targets and Myc targets https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19808871-TableS3 19808871.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 514.788507333615 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003365 Uterine Rajkumar09 20genes 16 Homo sapiens Additional File 2. Genes significant by different methods of analysis of the microarray data. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19832977-TableS1 19832977.0 Uterine PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003477 Viral Zekri08 12genes 10 Homo sapiens Table 4: Genes involved in the molecular function of the up regulated genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18959789-Table4 18959789.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001541 Leukemia Kiiveri08 100genes E2A-PBX1Parallel 68 Homo sapiens Table S10 Top 100 chi-square probe sets selected for E2A-PBX1 in parallel format https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18410693-TableS10 18410693.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001542 Leukemia Kiiveri08 100genes Hyperdiploid 80 Homo sapiens Table S11 Top 100 chi-square probe sets selected for Hyperdiploid https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18410693-TableS11 18410693.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 205.534223360081 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001543 Leukemia Kiiveri08 100genes MLLParallel 55 Homo sapiens Table S12 Top 100 chi-square probe sets selected for MLL in parallel format https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18410693-TableS12 18410693.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.454979699068545 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001544 Leukemia Kiiveri08 100genes T-ALLParallel 64 Homo sapiens Table S13 Top 100 chi-square probe sets selected for T-ALLin parallel format https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18410693-TableS13 18410693.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 188.274474278433 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001545 Leukemia Kiiveri08 100genes TEL-AML1Parallel 62 Homo sapiens Table S14 Top 100 chi-square probe sets selected for TEL-AML1 parallel format https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18410693-TableS14 18410693.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.51538980004493 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001546 Leukemia Kiiveri08 100genes BCR-ABLParallel 70 Homo sapiens Table S3 Top 100 chi-square probe sets selected for BCR-ABL in decision tree format https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18410693-TableS3 18410693.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.92599105387364 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002999 StemCell West07 25genes Decreased 19 Homo sapiens Table 2b. Decreased genes in pediatric ACT https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17234769-Table2b 17234769.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 26.449970771629 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003000 StemCell West07 350genes 272 Homo sapiens Table S2a. Upregulated in Tumor Relative to Normal https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17234769-TableS2a 17234769.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 414.313762027552 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003001 StemCell West07 669genes 514 Homo sapiens Table S2b. Downregulated in Tumor Relative to Normal https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17234769-TableS2b 17234769.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 17.736112757078 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003003 StemCell West07 97genes 46 Homo sapiens Table S3b. Downregulated in Pediatric Tumor vs Normal (Zam) compared to Adult Tumor vs Normal (Gio) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17234769-TableS3b 17234769.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 15.0907633329433 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003004 StemCell West07 56genes FetalvsAdultNormalCortex 27 Homo sapiens Table S4a. Upregulated in Pediatric Tumor vs Normal (Zam) compared to Fetal vs Adult Normal Cortex (Rainey) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17234769-TableS4a 17234769.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 115.567327345095 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003005 StemCell West07 71genes 41 Homo sapiens Table S4b. Downregulated in Pediatric Tumor vs Normal (Zam) compared to Fetal vs Adult Normal Cortex (Rainey) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17234769-TableS4b 17234769.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 39.8401230808192 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003006 StemCell West07 23genes 17 Homo sapiens Table S5a. Upregulated in ACC relative to Adenoma https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17234769-TableS5a 17234769.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 3.38537387017255 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003007 StemCell West07 29genes 23 Homo sapiens Table S5b. Downregulated in ACC relative to Adenoma https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17234769-TableS5b 17234769.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 3.23206205559147 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000490 Breast Forget07 15genes 6 Homo sapiens Table I. List of overexpressed candidate genes in breast cancer compared to normal tissues identified by cDNA (EST) and the SAGE DGED from the CGAP server. ?-actin and ubiquitin C are referenced as ubiquitously-expressed genes. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17245340-SuppTable1 17245340.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 38.857938718663 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002471 Ovarian Menendez07 148genes 5-aza-dCtreatment 109 Homo sapiens Additional File 1. Overlap between genes displaying a significant (p https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17254359-AddFile1 17254359.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 4.72191090392614 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003147 StemCell Fang09 79genes 73 Homo sapiens Table 1. Selected genes up-regulated by hypoxia in human monocyte-derived macrophages in vitro https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19454749-Table1 19454749.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 619.008778894383 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000501 Breast Huper07 66genes BasalCells 52 Homo sapiens Table 1a. Genes most differentially expressed in basal cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409405-Table1a 17409405.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 105.939269920866 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000502 Breast Huper07 66genes LuminalCells 57 Homo sapiens Table 1b. Genes most differentially expressed in luminal cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409405-Table1b 17409405.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 23.1150887560728 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002477 Ovarian Maloney07 84genes 67 Homo sapiens Table 1a. Genes that show decreased expression at the mRNA level in A2780 human ovarian cancer cells treated with 17AAG https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409432-Table1a 17409432.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 319.914010342084 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002478 Ovarian Maloney07 45genes 37 Homo sapiens Table 1b. Genes that show increased expression at the mRNA level in A2780 human ovarian cancer cells treated with 17AAG https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409432-Table1b 17409432.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 4.8206086269096 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002553 Pancreas Cui07 63genes 45 Homo sapiens Table 1. Overexpressed genes under glucose-deprived conditions https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409444-Table1 17409444.0 Pancreas PAGER curation team PAGER-contact@googlegroups.com CURRENT 51.3731660762514 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000503 Breast Winter07 126genes 87 Homo sapiens Table S2: The list of up-regulated genes of the hypoxia metagene https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409455-TableS2 17409455.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 10.5223037497134 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000504 Breast Winter07 67genes 46 Homo sapiens Table S3: The list of down-regulated genes of the hypoxia metagene https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409455-TableS3 17409455.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 34.3618997788089 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002767 Skin Alonso07 187genes 156 Homo sapiens Table 2. Functional categories of differentially expressed genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409456-Table2 17409456.0 Skin PAGER curation team PAGER-contact@googlegroups.com CURRENT 64.8465993970699 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002768 Skin Alonso07 41genes 34 Homo sapiens Table 3. EMT-related genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409456-Table3 17409456.0 Skin PAGER curation team PAGER-contact@googlegroups.com CURRENT 31.3190579351195 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002769 Skin Alonso07 22genes 18 Homo sapiens Table 4. Melanoma and neural-related genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17409456-Table4 17409456.0 Skin PAGER curation team PAGER-contact@googlegroups.com CURRENT 16.9720624486442 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001624 Leukemia Ueno09 30genes HighestUpRegulation3Days 22 Homo sapiens Supplementary Table S1. Thirty genes showing the highest up-regulation at 3 days after PU.1 induction https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749795-SuppTable1 19749795.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 890.474145100748 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001625 Leukemia Ueno09 30genes MostDownRegulated1Day 19 Homo sapiens Supplementary Table S2. Thirty genes showing the most down-regulation 1 day after PU.1 induction https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749795-SuppTable2 19749795.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001345 Leukemia Falt05 50genes UpRegulatedVH3a 39 Homo sapiens Table S2c. Genes upregulated in VH3-21+ B-CLLa https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15817677-TableS2c 15817677.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 12.0681903334582 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000351 Breast Itoh05 98genes 65 Homo sapiens Table 1. The Functional Grouping of Hormone Up-Regulated and Inhibitor(s) Down-Regulated Genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15831674-Table1 15831674.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 4.8711836956042 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000352 Breast Itoh05 92genes 60 Homo sapiens Table 2. The Functional Grouping of Hormone Down-Regulated and Inhibitor(s) Up-Regulated Genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15831674-Table2 15831674.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 80.9692190637854 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000353 Breast Itoh05 45genes 40 Homo sapiens Table 3. The List of Aromatase Inhibitors/TamoxifenModulated Genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15831674-Table3 15831674.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 12.2043948378096 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001346 Leukemia Alcalay05 369genes 300 Homo sapiens Table S2. Decreased and increased expression in NPMc+ leukemias https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15831697-TableS2 15831697.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 224.043364275953 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001347 Leukemia Alcalay05 160genes 122 Homo sapiens Table S3. Predictor genes identified with SAM https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15831697-TableS3 15831697.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 28.1433981784399 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001037 Esophagus Kimchi05 213genes 169 Homo sapiens Table1S. Selected genes included in clusters shown on Fig.2 and Fig.3 https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15833844-Table1S 15833844.0 Esophagus PAGER curation team PAGER-contact@googlegroups.com CURRENT 31.866227315411 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001038 Esophagus Kimchi05 18genes 15 Homo sapiens Table 2a. Genes up-regulated in Barrett https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15833844-Table2a 15833844.0 Esophagus PAGER curation team PAGER-contact@googlegroups.com CURRENT 6.16998950682057 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001039 Esophagus Kimchi05 06genes 5 Homo sapiens Table 2b. Genes down-regulated in Barrett https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15833844-Table2b 15833844.0 Esophagus PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001040 Esophagus Kimchi05 96genes 82 Homo sapiens Table 2S. Genes differentially expressed relative to normal epithelium both in BE and ADC https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15833844-Table2S 15833844.0 Esophagus PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.957931638913234 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001829 Lung Kakiuchi04 51genes 38 Homo sapiens Table 4. List of 51 candidate genes for discriminating responder (PR) from non-responder (PD) to gefitiniba https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15496427-Table4 15496427.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001830 Lung Oshita04 9genes 8 Homo sapiens Table III. Genes closely associated with sensitivity in chemotherapy for lung cancer. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15500010-table3 15500010.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 54.1140529531568 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000311 Breast Bieche04 29genes invasive 25 Homo sapiens Table 1 List of the significantly dysregulated genes in IBCs relative to non-IBCs https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=15501955-Table1 15501955.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 690.707814226799 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000871 Colon Craene05 25genes 16 Homo sapiens Supplementary Table 2b. Genes induced by hSnail https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16024625-SuppTable2b 16024625.0 Colon PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.47263249348393 N 1.0 13-AUG-20 GeneSigDB G 2942
WAG000233 generation of amyloid b-peptide by ps1 4 Homo sapiens Alzheimer's disease is associated with dense aggregations of proteins in the brain called amyloid plaques that contain beta-amyloid fragments as a primary component. If the development of amyloid plaques is responsible for neurodegeneration in Alzheimer's disease, reduction of beta-amyloid formation may prevent the development and progression of disease symptoms. Beta-amyloid fragments are derived from proteolytic processing of amyloid precursor protein (APP) in neurons, and the subsequent release of fragments into the extracellular space. APP in the ER is cleaved at residue 17 by alpha-secretase protease activity encoded by ADAM-10 and TACE. Beta-secretase activity, recently identified as BACE, cleaves in the N-terminus of the beta-amyloid fragment. Gamma-secretase cuts APP within the transmembrane domain at amino acids 40 and 42, releasing the beta-amyloid fragment containing residues 1-40/42 as well as shorter products such as p3 (residues 17-40/42) that requires alpha-secretase cleavage. The gamma-secretase activity requires the transmembrane protein Presenilin-1 that is itself cleaved into an N-termil and C-termil fragment that both are required for gamma-secretase activity. Mutations in presenilin-1 have been genetically associated with familial forms of Alzheimer's disease, further supporting the role of APP processing the development of the disease. Inhibition of the beta- or gamma-secretases may provide a mechanism to treat this disease. Other mechanisms may include altering degradation of beta-amyloid, and the use of vaccines against beta-amyloid to remove aggregates. https://cgap.nci.nih.gov/Pathways/BioCarta/h_appPathway PAGER curation team PAGER-contact@googlegroups.com 756.782075991189 1.0 13-AUG-20 BioCarta P 252
WAG000234 regulation of pgc-1a 9 Homo sapiens Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nuclear receptors and coordites transcriptiol programs important for energy metabolism and energy homeostasis. Ippropriate increases in PGC-1a activity have been linked to a number of pathological conditions including heart failure and diabetes. PGC-1a is highly expressed in metabolically active tissues including brown fat, skeletal muscle and heart. PGC-1a has been implicated in mitochondrial biogenesis in the heart and increased mitochondrial respiration in brown fat. PGC-1a is a coactivator for many factors including, CBP, Scr-1, PPARa, GR (glucocorticoid receptor), THR (thyroid hormone receptor), several orphan receptors and MEF2. This pathway illustrates two of the cofactor regulatory factors MEF2 and PPARa) and an example orphan receptor feedback inhibition loop. Glut4 is used as an example of the downstream elements leading to changes in metabolism. https://cgap.nci.nih.gov/Pathways/BioCarta/h_pgc1aPathway PAGER curation team PAGER-contact@googlegroups.com 165.825717332466 1.0 13-AUG-20 BioCarta P 252
WAG000212 brca1 dependent ub ligase activity 8 Homo sapiens BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiquitin ligase that catalyzes the synthesis of polyubiquitin chains. UbcH5c and UbcH7 also interact with the BRCA1/BARD1 complex with similar affinity (not shown on this figure). Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitition and is capable of monoubiquititing histones 2A and 2AX in vitro https://cgap.nci.nih.gov/Pathways/BioCarta/h_bard1Pathway PAGER curation team PAGER-contact@googlegroups.com 2952.437543547 1.0 13-AUG-20 BioCarta P 252
WAG001043 hop pathway in cardiac development 4 Homo sapiens Homeodomain transcription factors comprise a large family of D binding factors that regulate transcription and development. Many homeodomain genes arranged in genomic clusters determine anterior-posterior patterning, while others determine the fate of cells in specific tissues. The proliferation of cardiac myocytes and their differentiation early in development are both dependent on the coordite expression and action of serum response factor (SRF), GATA4 (see GATA pathway) and the homeodomain factor Nkx2-5. All three of these factors are expressed in developing cardiomyocytes and induce expression of cardiac genes. Disruption of the Nkx2-5 gene in mice leads to embryonic lethality and defective cardiac development. SRF also plays a duel role in cardiac development, influencing both cardiomyocyte proliferation and differentiation depending on the stage and other sigls that are present. https://cgap.nci.nih.gov/Pathways/BioCarta/h_hopPathway PAGER curation team PAGER-contact@googlegroups.com 282.003028634361 1.0 13-AUG-20 BioCarta P 252
WAG000426 calcium signaling by hbx of hepatitis b virus 13 Homo sapiens Hepatitis B is a small D virus that contains only 4 open reading frames in its genome. Three of these ORFs have been identified as the envelope, capsid and polymerase genes, while the function of the fourth has remained unknown until recently. The fourth reading frame has been called the X gene and produces HBx protein that is essential for viral replication in liver cells and acts broadly to activate a variety of transcription factors. One hypothesis of HBx activity has been that it enters the nucleus to act as a transcriptiol regulator. One piece of evidence supporting this mechanism of HBx action is that HBx interacts with the transcription factor CREB and increases its D-binding activity. This mechanism does not explain all of the effects of HBx however. Another hypothesis for the HBx mechanism of action is that HBx increases calcium release into the cytoplasm. This mechanism of action is consistent with the variety of transcription factors and kises affected by HBx since calcium sigling affects many different sigling pathways. HBx does not appear to interact directly with Ras or protein kises but does appear to activate the calcium activate protein kise Pyk2. A domint negative form of Pyk2 blocks HBx activity and the involvement of calcium in HBx activation of Pyk2 is indicated by the action of several molecular probes that alter cytosolic calcium sigling. BAPTA-AM chelates cytosolic and blocks HBx action. Cyclosporin A blocks mitochondrial calcium sigling and also blocked HBx sigling. CGP37157 is a compound that blocks the mitochondrial sodium calcium pump and also blocks hepatitis B viral replication, indicating that mitochondrial calcium sigling is the target of HBx function. Compounds that elevate cytoplasmic calcium levels (valinomycin and thapsigargin) increase the rate of replication of viruses that lack HBx, further supporting the role of HBx as an inducer of intracellular calcium sigling. The mechanism by which HBx causes calcium release is not yet known. Src activation appears to induce viral replication while Ras sigling does not, suggesting that the activation of Ras sigling by HBx may play a distinct function, perhaps the induction of cancer. https://cgap.nci.nih.gov/Pathways/BioCarta/h_HBxPathway PAGER curation team PAGER-contact@googlegroups.com 2407.38292253789 1.0 13-AUG-20 BioCarta P 252
FEX002635 Prostate Nadiminty06 50genes UpRegulated 47 Homo sapiens Table 1. Top 50 up-regulated genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16533764-Table1 16533764.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 22.2400690942524 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002636 Prostate Nadiminty06 50genes DownRegulated 46 Homo sapiens Table 2. Top 50 down-regulated genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16533764-Table2 16533764.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 27.4346585685231 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002637 Prostate Nadiminty06 110genes 71 Homo sapiens Table 3. PSA-regulated genes grouped into function classes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16533764-Table3 16533764.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 23.9610568581064 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002638 Prostate Nadiminty06 15genes 14 Homo sapiens Table 4. Changes on the expression of osteogenic associated genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16533764-Table4 16533764.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 185.508125757801 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000414 Breast Muggerud06 232genes 170 Homo sapiens Supplementary table 2 ANOVA-analysis output. ANOVA analysis of all the genes immobilized on the MetriGenix breast cancer chip. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16536878-SuppTable2 16536878.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 75.2038939641573 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000415 Breast Muggerud06 27genes LuminalvNonLuminal 21 Homo sapiens Supplementary table 4 PAM-analysis output. PAM output of the most differentially expressed genes between the two groups: luminal and non-luminal https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16536878-SuppTable4 16536878.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 10.2779836916234 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001872 Lung LopezRio06 25genes OverallSurvivalAfterSurgery 20 Homo sapiens Supplemental Table 3a. Top 25 Probe Sets Significantly Associated With Overall Survival After Surgery https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16540645-SuppTable3a 16540645.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 4.16254416961131 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001873 Lung LopezRio06 25genes SurgeryinEpithelioidMesotheliomas 22 Homo sapiens Supplemental Table 4a. Top 25 Probe Sets Significantly Associated With Overall Survival After Surgery in Epithelioid Mesotheliomas Only https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16540645-SuppTable4a 16540645.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.92775151924375 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001874 Lung LopezRio06 25genes ShortTermvsLongTerm 18 Homo sapiens Supplemental Table 5a. Top 25 Probe Sets Differentially Expressed Between Short-term ( https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16540645-SuppTable5a 16540645.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 152.99644451254 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001547 Leukemia Kiiveri08 100genes E2A-PBX1Tree 63 Homo sapiens Table S4 Top 100 chi-square probe sets selected for E2A-PBX1 in decision tree format https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18410693-TableS4 18410693.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001549 Leukemia Kiiveri08 100genes MLLTree 64 Homo sapiens Table S6 Top 100 chi-square probe sets selected for MLL in decision tree format https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18410693-TableS6 18410693.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.568939556893956 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003478 Viral Zekri08 28genes 16 Homo sapiens Table 5: Up regulated gene symbols and related pathway. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18959789-Table5 18959789.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 24.5093228655545 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003078 StemCell Hoque08 28genes 21 Homo sapiens Table 2. Cancer-specific methylated genes and their proposed functions https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18413733-Table2 18413733.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 3.66644159351789 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003165 StemCell Hao09 173genes 121 Homo sapiens Supplementary Table S5. Common genes found as the candidates for CRC metastasis when cross-comparing differential genes expressed between SCP51 and SCP58 cells with the differential genes found between SCP58 and SW480/EGFP https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20077526-TableS5 20077526.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.643268499402369 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003166 StemCell Hao09 97genes 74 Homo sapiens Supplementary Table S7. Genes found in the top ten clusters using gene-annotation enrichment analysis of DAVID https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20077526-TableS7 20077526.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 6.13497712437028 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000609 Breast Finak08 26genes 22 Homo sapiens Table 2. Description of genes in the 26-gene stroma-derived prognostic predictor https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18438415-Table2.1 18438415.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 70.7213598058335 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001921 Lung Ma08 378genes 241 Homo sapiens SuppTable1. Down-regulated genes in the nm23-H1 siRNA-transfected cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18440302-SuppTable1 18440302.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.128586093251931 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001922 Lung Ma08 708genes 435 Homo sapiens SuppTable2. Up-regulated genes in the nm23-H1 siRNA-transfected cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18440302-SuppTable2 18440302.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 4.32423768000511 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003492 Viral Cairo08 78genes 62 Homo sapiens Table S4b. GSEA: Rank-ordered list of upregulated genes associated to ?-catenin mutations in hepatocellular carcinoma according to Stahl et al (2005) and Boyault et al (2007) in hepatoblastoma versus non-tumor liver. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19061838-TableS4b 19061838.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.768366659177713 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003493 Viral Cairo08 25genes 24 Homo sapiens Table S5. Overrepresented pathways (p https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19061838-TableS5 19061838.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 41.1741026538821 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001600 Leukemia Lenz08 385genes 335 Homo sapiens SuppTable3 Complete listing of expression signature genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19038878-SuppTable3 19038878.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 83.6929727851601 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000675 Breast Thorner09 217genes 159 Homo sapiens Supplementary Table 2 Dox-treated; 217 genes; FDR 2.75% Doxorubicin-induced genes: Treated HME-CC Control vs. Treated HME-CC.B-Myb https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19043454-TableS2 19043454.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 17629.4390628219 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002490 Ovarian Marchini08 6genes Partition1 6 Homo sapiens Partition 1 data expression validation by qRT-PCR https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19047114-Table2 19047114.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002491 Ovarian Marchini08 6genes Partition2 6 Homo sapiens Table 3. Partition 2 gene expression validation by qRT-PCR in the original and in the test set https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19047114-Table3 19047114.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 38.857938718663 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002492 Ovarian Marchini08 2genes 2 Homo sapiens Table 4. Data expression validation by qRT-PCR of two genes found differently expressed between stage I relapsing (R) or nonrelapsing (nR) tumor samples https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19047114-Table4 19047114.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.210526315789 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002679 Prostate Wang08 79genes 56 Homo sapiens Supplementary Table 2. 79 genes identified to be significantly differentially expressed between castrate-resistant and androgen-dependent clinical samples with P https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19047173-tableS2 19047173.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 6.5536992922206 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003086 StemCell Lim08 50genes 47 Homo sapiens Table 1 Top 50 most highly upregulated genes (Specific upregulated genes profiles in CD41+ cells) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18510698-Table1 18510698.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 44.7905218287688 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003087 StemCell Lim08 25genes 23 Homo sapiens Table 2 Top 25 most highly downregulated genes (negatively regulates erythropoiesis which share identical upstream regulatory pathways with megakaryopoiesis) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18510698-Table2 18510698.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 39.1453400746266 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003088 StemCell Lim08 35genes 33 Homo sapiens Table 3 Genes associated with cell adhesion https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18510698-Table3 18510698.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 338.401652547822 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003089 StemCell Lim08 14genes 12 Homo sapiens Table 4 Genes associated with lipid biosynthesis https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18510698-Table4 18510698.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 253.841570513892 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003090 StemCell Lim08 23genes 23 Homo sapiens Table 5 Genes associated with transcription regulator activity https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18510698-Table5 18510698.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 27.0965563808238 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001626 Leukemia Ueno09 30genes MostDownRegulated3Days 22 Homo sapiens Supplementary Table S3. Thirty genes showing the most down-regulation at 3 days after PU.1 induction https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749795-SuppTable3 19749795.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 94.7692044067418 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001627 Leukemia Ueno09 30genes HighestUpRegulation1Day 24 Homo sapiens Table 1. Thirty genes showing the highest upregulation at day 1 after PU.1 induction https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749795-Table1 19749795.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 3097.94361173957 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001628 Leukemia Ueno09 26genes 18 Homo sapiens Table 2. Changes in cell cycle-related genes after PU.1 induction https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749795-Table2 19749795.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 7022.59626817873 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001760 Liver Chan09 15genes 15 Homo sapiens Table 1. Aberrantly expressed genes earlier identified in HCC that are also aberrantly regulated by the HCCTR mutants https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749797-Table1 19749797.0 Liver PAGER curation team PAGER-contact@googlegroups.com CURRENT 6.16998950682057 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001761 Liver Chan09 22genes 21 Homo sapiens Table 2. Partial list of cancer-implicated genes aberrantly regulated by the HCCTR mutants https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749797-Table2 19749797.0 Liver PAGER curation team PAGER-contact@googlegroups.com CURRENT 10.2779836916234 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001955 Lung Olaussen09 20genes 18 Homo sapiens Table 2. Selected examples (see complete list in Supplementary Table S2) of the differential transcriptional effects in A549 cells promoted by single or combined treatments of pazopanib and lapatinib https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749798-Table2 19749798.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 34.0848872260625 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001956 Lung Olaussen09 174genes 108 Homo sapiens Supplementary Table S2 List of the 174 genes that are specifically modified by the pazopanib/lapatinib combination in A549 cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19749798-TableS2 19749798.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 10.2704247370386 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001629 Leukemia Li09 419genes 394 Homo sapiens Table S6. 418 differentially expressed genes 39 which overlapped with the 62 classification markers we identified https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19755675-TableS6 19755675.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 110.653064172098 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000739 Breast Vegran09 28genes PandQValues 23 Homo sapiens Table 3. P-value and q-value for the 28 genes constituting the gene signature https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19755993-Table3 19755993.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000740 Breast Vegran09 28genes Details 25 Homo sapiens Table 4. Details of the 28 genes contained in discriminating profile https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19755993-Table4 19755993.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002348 Lymphoma VanLoo09 135genes 113 Homo sapiens Supplementary Table 1a. Gene expression signatures of NLPHL https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19797726-SuppTable1a 19797726.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 31.0763370688902 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002349 Lymphoma VanLoo09 407genes 360 Homo sapiens Supplementary Table 1b. Gene expression signatures of THRLBCL https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19797726-SuppTable1b 19797726.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 100.156767628063 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002350 Lymphoma VanLoo09 25genes 17 Homo sapiens Supplementary Table 5. Expression values of T cell genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19797726-SuppTable5 19797726.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 2542.87595688769 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002351 Lymphoma VanLoo09 11genes 10 Homo sapiens Table 2A. A selection of genes differentially expressed between NLPHL and THRLBCL (P https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19797726-Table2a 19797726.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 863.799125402899 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002352 Lymphoma VanLoo09 40genes 39 Homo sapiens Table 2B. A selection of genes differentially expressed between NLPHL and THRLBCL (P https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19797726-Table2b 19797726.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 646.049453984022 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001630 Leukemia Visser09 75genes 70 Homo sapiens Table 1 Summary of differentially expressed genes in siRNA-LATS1/2-treated HeLa cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19799973-Table1 19799973.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 30.4892530187468 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002316 Lymphoma Miyazaki08 121genes 64 Homo sapiens Table SI. (A) Signature genes overexpressed in CD21? DLBCLs. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18537973-SuppTable1a 18537973.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.18089911808991 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002317 Lymphoma Miyazaki08 70genes 47 Homo sapiens Table SI. (B) Signature genes overexpressed in CD21+ DLBCLs. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18537973-SuppTable1b 18537973.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001103 HeadandNeck Hensen08 26genes 24 Homo sapiens Table 2: Differentially expressed genes between N0 and N+ HNSCC as validated by the independent expression dataset https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18544165-Table2 18544165.0 Head and Neck Cancer PAGER curation team PAGER-contact@googlegroups.com CURRENT 80.7748120350555 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002318 Lymphoma Rimsza08 37genes 34 Homo sapiens Table 1. Prognostic genes identified in prior studies of CHOP-treated patients assessed using ArrayPlate https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18544678-Table1 18544678.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 53.8602176837471 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002319 Lymphoma Rimsza08 36genes 29 Homo sapiens Table 2. Results of univariate analyses of gene expression with overall survival https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18544678-Table2 18544678.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 49.8012278706663 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001563 Leukemia Mollinedo08 117genes 114 Homo sapiens Table 1 Major gene expression changes in DMSO-induced differentiation of HL-60 cells and peripheral blood human neutrophils https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18547747-Table1 18547747.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 774.024789214452 N 1.0 13-AUG-20 GeneSigDB G 2942
WAG000235 il 6 signaling pathway 10 Homo sapiens Interleukin-6 (IL-6) is a cytokine that provokes a broad range of cellular and physiological responses. In addition to playing a role in inflammation and hematopoiesis, IL-6 is involved in other processes such as neurol differentiation and bone loss. To produce these effects IL-6 sigls through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and gp130, a receptor subunit shared in common with other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events including activation of JAK kises and activation of ras-mediated sigling. Activated JAK kises phosphorylate and activate STAT transcription factors, particularly STAT3, that move into the nucleus to activate transcription of genes containing STAT3 response elements. The ras-mediated pathway, acting through Shc, Grb-2 and Sos-1 upstream and activating Map kises downstream, activates transcription factors such as ELK-1 and NF-IL-6 (C/EBP-beta) that can act through their own cogte response elements in the genome. These factors and other transcription factors like AP-1 and SRF (serum response factor) that respond to many different sigling pathways come together to regulate a variety of complex promoters and enhancers that respond to IL-6 and other sigling factors. https://cgap.nci.nih.gov/Pathways/BioCarta/h_il6Pathway PAGER curation team PAGER-contact@googlegroups.com 1975.35301802979 1.0 13-AUG-20 BioCarta P 252
WAG000236 cdk regulation of dna replication 18 Homo sapiens Initiation of D replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events to once per replication origin per S phase. Its control has been uncovered by the discovery of the cyclin dependent kises (CDKs) as master regulators of the cell cycle and the initiator proteins of D replication, such as the Origin Recognition Complex (ORC), Cdc6/18, Cdt1 and the mini-chromosome maintence complex (Mcm). The proteins and the sequence of events involved in this process are conserved throughout the eukaryotic kingdom. First, the ORC comprised of six proteins binds to replication origins in the chromosomal D. At the end of mitosis, ORC, Cdc6/18 and Cdt1 assist the binding of Mcm proteins 2? to chromatin, and chromatin becomes licensed for replication. The activated Mcm complex functions as a replicating helicase and moves along with the replication fork to bring the origins to the unlicensed state. The cycling of CDK activity in the cell cycle regulates the two states of replication origins, the licensed state in G1-phase and the unlicensed state for the rest of the cell cycle. The restriction on licensing is relieved when CDK falls off at the completion of mitosis to allow a new round of replication. https://cgap.nci.nih.gov/Pathways/BioCarta/h_mcmPathway PAGER curation team PAGER-contact@googlegroups.com 7161.25541282253 1.0 13-AUG-20 BioCarta P 252
WAG000412 visceral fat deposits and the metabolic syndrome 8 Homo sapiens Obesity is associated with many adverse health effects, including an increased risk of diabetes and heart disease. The combined condition of obesity, diabetes and heart disease is sometimes referred to as the metabolic syndrome. One of the factors that best correlates obesity with the rest of the metabolic syndrome is not overall body mass, but the distribution of adipose tissue in the abdomil region, visceral obesity. Glucocorticoids have been associated as a risk factor for the metabolic syndrome, but most obese individuals have normal levels of circulating corticosteroids. Active corticosteroids such as cortisol and corticosterone activate the glucocorticoid receptor, a nuclear hormone receptor and transcription factor. Obese individuals have elevated levels in adipose tissue of a key enzyme in glucocorticoid metabolism, 11beta hydroxysteroid dehydrogese type 1 (11betaHSD-1). 11betaHSD-1 interconverts ictive corticosteroids and the active form. When present in cells, 11betaHSD-1 can convert ictive corticosteroids from the blood to create locally high concentrations in a tissue such as adipose tissue. When activated in adipose tissue, GR increases the level of visceral fat, induces insulin resistance and dyslipidemias that increase the risk of heart disease. https://cgap.nci.nih.gov/Pathways/BioCarta/h_vobesityPathway PAGER curation team PAGER-contact@googlegroups.com 1835.75575825383 1.0 13-AUG-20 BioCarta P 252
WAG001015 no2-dependent il-12 pathway in nk cells 7 Homo sapiens Macrophages and NK cells help provide inte immunity against infection by intracellular parasites and communicate with each other to regulate this process. When stimulated, macrophages secrete the cytokine IL-12 that is essential for activation of the cytotoxic activity of tural killer (NK) cells. IL-12 stimulates this NK cell response through activation of a JAK/STAT sigling pathway. Binding of IL-12 to its receptor on NK cells causes tyrosine phosphorylation and activation of JAK2 and another JAK kise, Tyk2. Tyk2 in turn phosphorylates the transcription factor STAT4, which can then translocate to the nucleus to activate genes, including the expression of interferon-gamma. IFN-gamma and IL-12 induce the differentiation of TH1 helper T cells that activate macrophages through interferon-gamma. https://cgap.nci.nih.gov/Pathways/BioCarta/h_no2il12Pathway PAGER curation team PAGER-contact@googlegroups.com 1980.02549414132 1.0 13-AUG-20 BioCarta P 252
WAG001016 effects of calcineurin in keratinocyte differentiation 7 Homo sapiens The differentiation of keratinocytes constantly replenishes the upper layers of human skin we lose each day. One factor that contributes to termil keratinocyte differentiation is increased levels of intracellular calcium. Adding calcium to the medium of cultured keratinocytes elevates intracellular calcium and triggers differentiation. Intracellular calcium levels are also increased in response to phospholipase C activation, producing IP3 and releasing calcium from stores in the ER. Intracellular calcium alters multiple sigling pathways, one of which is binding to calmodulin to activate the serine-threonine protein phosphatase calcineurin. Calcineurin dephosphorylates and activates the transcription factor NFAT and both calcineurin and NFAT are expressed in differentiating keratinocytes. Activated NFAT can regulate transcription through binding its own cogte D binding site. One marker of keratinocyte differentiation, the p21 gene, is activated by NFAT by a different mechanism, with NFAT activating the p21 promoter by acting as a coactivator for the transcription factors Sp1 and Sp3. https://cgap.nci.nih.gov/Pathways/BioCarta/h_calcineurinPathway PAGER curation team PAGER-contact@googlegroups.com 209.348419931353 1.0 13-AUG-20 BioCarta P 252
FEX001875 Lung LopezRio06 25genes 25Shortest25Longest 19 Homo sapiens Supplemental Table 6a. Top 25 Probe Sets Differentially Expressed Between 25 Shortest and 25 Longest Survivors (n=50) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16540645-SuppTable6a 16540645.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.908080059303187 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001876 Lung LopezRio06 20genes 17 Homo sapiens Table 3. Top 20 probe sets differentially expressed according to histology https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16540645-Table3 16540645.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.47263249348393 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001877 Lung LopezRio06 35genes 26 Homo sapiens Table 4. MSKCC prognostic classifier https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16540645-Table4 16540645.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 237.592195301579 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002934 StemCell Vikesaa06 17genes 17 Homo sapiens Table 1: Downregulated transcripts in IMP-depleted cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16541107-Table1 16541107.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 37.3965149909604 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000892 Colon Graudens06 863genes 671 Homo sapiens SuppTable3. Descriptive statistics and annotation of differentially expressed genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16542501-SuppTable3 16542501.0 Colon PAGER curation team PAGER-contact@googlegroups.com CURRENT 119.002466176474 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000893 Colon Graudens06 30genes 29 Homo sapiens Table 2. Validation of microarray gene expression data https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16542501-Table2 16542501.0 Colon PAGER curation team PAGER-contact@googlegroups.com CURRENT 392.58503611262 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002937 StemCell Innes06 108genes 98 Homo sapiens Table 1. Statistically Significant Differentially Regulated Genes in IR-Treated Lymphoblasts and Fibroblasts Classified into Functional Categories https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16547157-Table1 16547157.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 505.185006670638 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001390 Leukemia Ge06 105genes 79 Homo sapiens Table 2. Top 105 probe sets selected for genes underexpressed in DS AMkL compared with non-DS AmkL https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16249385-Table2 16249385.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 46.5006553711151 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001391 Leukemia Ge06 106genes 81 Homo sapiens Table 3. Top 105 probe sets selected for genes overexpressed in DS AMkL compared with non-DS AMkL https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16249385-Table3 16249385.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.00931101096926 N 1.0 13-AUG-20 GeneSigDB G 2942
WAG000848 tgf beta signaling pathway 15 Homo sapiens TGF-beta regulates growth and proliferation of cells, blocking growth of many cell types. The TGF-beta receptor includes type 1 and type 2 subunits that are serine-threonine kises and that sigl through the SMAD family of transcriptiol regulators. Defects in TGF-beta sigling, includes mutation in SMADs, have been associated with cancer in humans. Prior to activation, receptor regulated SMADs are anchored to the cell membrane by factors like SARA (SMAD Anchor for Receptor Activation) that brings the SMADs into proximity of the TGF receptor kises. Binding of TGF induces phosphorylation and activation of the TGF-beta R1 receptor by the TGF-beta R2 receptor. The activated TGF-beta R1 phosphorylates SMAD2 and SMAD3, which bind to the SMAD4 mediator to move into the nucleus and form complexes that regulate transcription. SMADs regulate transcription in several ways, including binding to D, interacting with other transcription factors, and interacting with transcription corepressors and coactivators like p300 and CBP. SMAD-7 represses sigling by other SMADs to down-regulate the system. Other sigling pathways like the MAP kise-ERK cascade are activated by TGF-beta sigling, modulate SMAD activation. SnoN also regulates TGF-beta sigling, by binding to SMADs to block transcriptiol activation. TGF-beta sigling causes degradation of SnoN, releasing SMADs to regulate transcription, and also activates expression of SnoN, to down-regulate SMAD sigling at later times. https://cgap.nci.nih.gov/Pathways/BioCarta/h_tgfbPathway PAGER curation team PAGER-contact@googlegroups.com 1290.44054399597 1.0 13-AUG-20 BioCarta P 252
WAG000242 lectin induced complement pathway 11 Homo sapiens The complement cascade of proteolytic factors involved in cellular lysis can be initiated by several different factors, including antibody-dependent and antibody-independent recognition of infectious organisms (see classical and altertive complement pathways). In the lectin-induced complement cascade, carbohydrates on the surface of microbial cells activate the complement cascade by binding to mann-binding lectin (also called the mann-binding protein, Mbl/Mbp). Mbp is an acute phase serum protein whose expression is induced by microbial infection. The binding of Mbl to microbial ligands activates the Mbl associated serine proteases Masp1 and Masp2, triggering the cleavage of C2 and C4 to create C4bC2a, a C3 convertase that cleaves large numbers of C3. Masp1 and Masp2 are similar to the C1 protease in the classical complement pathway. Once formed the C3 convertase cleaves and activates the remaining complement factors leading ultimately to formation of a pore in the bacterial membrane by the membrane attack complex (MAC) that lyses the bacterial cell. The lectin-induced pathway also appears to play an important role of the activation of phagocytotic cells by infection. Although the initiating event activating the complement cascade is distinct in the lectin-induced pathway, from the C3 convertase onward the lectin induced complement pathway is the same as the classical complement pathway. Since antibodies are not required in the lectin-induced pathway, this aspect of the immune response is part of the inte immune response. The importance of this pathway to the immune response has been demonstrated by the identification of children and adults with little or no Mbl who lacked normal phagocytotic responses and are highly susceptible to infection. https://cgap.nci.nih.gov/Pathways/BioCarta/h_lectinPathway PAGER curation team PAGER-contact@googlegroups.com 3049.6546849377 1.0 13-AUG-20 BioCarta P 252
FEX003091 StemCell Mishra08 289genes 179 Homo sapiens Table 1. Top 10 pathways enriched in genes induced by the TCM-treated hMSCs for 30 d https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18519693-Table1 18519693.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 609.993675878444 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003426 Viral Okamoto06 36genes 29 Homo sapiens TABLE 2. The 36 genes commonly associated with the multicentric occurrence?associated genes and the multicentric recurrence?associated genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16788756-Table2 16788756.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 27.2362937334995 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003357 Uterine Lucerna06 67genes 52 Homo sapiens Supplementary Table 2: Genes upregulated by EGR-1 over 25 fold 24 h post-infection (67 genes) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16818645-SuppTable2 16818645.0 Uterine PAGER curation team PAGER-contact@googlegroups.com CURRENT 3.65901681248842 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003240 Stomach Zhao09 324genes 288 Homo sapiens Supporting Information Table 2. Up-regulated genes comparing malignant and premalignant lesions https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19306436-TableS2a 19306436.0 Stomach PAGER curation team PAGER-contact@googlegroups.com CURRENT 182.466446300571 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003241 Stomach Zhao09 168genes 149 Homo sapiens Supporting Information Table 2. Down-regulated genes comparing malignant and premalignant lesions https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19306436-TableS2b 19306436.0 Stomach PAGER curation team PAGER-contact@googlegroups.com CURRENT 3.79983777611142 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001046 Esophagus Ito08 22genes 21 Homo sapiens Table 3. Genes differentially expressed after anti-PTTG1 siRNA treatment in HSA/c and KYSE140 cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18451147-Table3 18451147.0 Esophagus PAGER curation team PAGER-contact@googlegroups.com CURRENT 27.6341938654447 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000596 Breast Vincent-Salomon08 1001genes 740 Homo sapiens 1001 genes exhibiting an interquartile range of https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18381933-SuppTableS4 18381933.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 7.36517477495041 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000597 Breast Mutarelli08 1488genes 1101 Homo sapiens Additional File 2-Selected gene list corresponding to the cluster analysis shown in Figure 2 and 3. Each gene is accompanied by its measured signal over time (data shows average log2 ratios normalized with quantile method). Genes with one or more missing https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18387200-Genes 18387200.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 631.418248217705 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003070 StemCell Yang08 53genes 44 Homo sapiens Table 1a. Selected Genes Differentially Expressed in High-Grade Astrocytomas (Genes up-regulated in gliomas) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18395814-Table1a 18395814.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 98.6347397830678 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003071 StemCell Yang08 49genes 41 Homo sapiens Table 1b. Selected Genes Differentially Expressed in High-Grade Astrocytomas (Genes down-regulated in gliomas) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18395814-Table1b 18395814.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 18.7896756191141 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003236 Stomach Galamb08 20genes 14 Homo sapiens Table 2c Genes differentially expressed (RMA and MAS 5 overlaps) between the subgroups https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18321301-Table2c 18321301.0 Stomach PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.05103042198234 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003237 Stomach Galamb08 6genes 5 Homo sapiens Table 2d Genes differentially expressed (RMA and MAS 5 overlaps) between the subgroups https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18321301-Table2d 18321301.0 Stomach PAGER curation team PAGER-contact@googlegroups.com CURRENT 23.9931740614334 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003287 Testicular Duale07 11genes 10 Homo sapiens Table 1: List of p53 responsive genes (n = 37). 26 genes were up-regulated and 11 genes were down-regulated in the TGCT cells following cisplatin exposure; B) 11 p53 target genes that are down-regulated in TGCT cells and up-regulated in HCT116 cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17711579-Table1b 17711579.0 Testicular PAGER curation team PAGER-contact@googlegroups.com CURRENT 5.1088534107402 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003288 Testicular Duale07 24genes 23 Homo sapiens Table 2: List of SAM-identified genes (n = 40) predicted as target for hsa-mir-372 and 373; A) 24 miR-372 https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17711579-Table2a 17711579.0 Testicular PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002483 Ovarian LePage08 34genes 25 Homo sapiens Figure 1. 34 probe sets identified differential expression between 17 serous tumors that were obtained from 10 patients showing early disease progression (within 18 months after surgery) and 7 patients who showed no disease progression in the 2 years foll https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18398031-Fig1 18398031.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 20.4690495384877 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002484 Ovarian LePage08 9genes primers 9 Homo sapiens Supplementary Table 1 Primers used in the study https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18398031-S1 18398031.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 7.82764811490126 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002671 Prostate Shepherd08 50genes 1 41 Homo sapiens TABLE I. Top 50GenesUp-RegulatedinCD133? Cells (Relative to Expression in CD133-) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18398820-table1 18398820.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 4.07802600866956 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002672 Prostate Shepherd08 50genes 2 43 Homo sapiens TABLE II. Top 50GenesUp-Regulatedin CD133- Cells (Relative to CD133? Cells) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18398820-table2 18398820.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 15.28910217021 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002673 Prostate Shepherd08 50genes 3 44 Homo sapiens TABLE IV. Top 50GenesUp-Regulatedin CD133? Cells FromHRPC (Ratio to CD133? Benign Samples) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18398820-table4 18398820.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 7.74818334045129 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002674 Prostate Shepherd08 50genes 4 44 Homo sapiens TABLE V. Top 50GenesUp-Regulatedin CD133- Cells FromHRPC (Ratio to CD133- Benign Samples) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18398820-table5 18398820.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 843.885336662101 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002300 Lymphoma Staege08 50genes UpRegulated HodgkinlymphvNorm 39 Homo sapiens Figure 1a. Gene set enrichment analysis (GSEA) of Hodgkin https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18400362-Figure1a 18400362.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 186.28246543123 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003079 StemCell Kumamoto08 10genes UpRegulated 9 Homo sapiens Table 1a. Nutlin-3ainduced p53-responsive genes in NHF-hTERT cells that are up-regulated https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18451145-Table1a 18451145.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003081 StemCell Kumamoto08 2005genes 1279 Homo sapiens Supplementary Table. S1 Up-regulated genes by nutlin-3a-induced p53 https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18451145-TableS1 18451145.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002094 Lung Kazeros08 14genes 12 Homo sapiens Table 3. Expression of apoptotic cell removal receptor genes in alveolar macrophages of normal smokers compared to normal nonsmokers https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18587056-Table3 18587056.0 Lung not cancer PAGER curation team PAGER-contact@googlegroups.com CURRENT 306.623797627584 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003163 StemCell Hao09 612genes 406 Homo sapiens Supplementary Table S3. The differential genes between SCP51 and SCP58 cells (SCP51 vs. SCP58 ) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20077526-TableS3 20077526.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 1.04003852438882 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003164 StemCell Hao09 359genes 237 Homo sapiens Supplementary Table S4. The differential genes between SW480/EGFP and SCP58 (SW480/EGFP vs. SCP58) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20077526-TableS4 20077526.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.216229219008927 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003446 Viral Schlecht07 38genes 27 Homo sapiens Table 3a. List of named genes that are differentially expressed (with higher expression) genes in HPV16+ and HPV16? primary HNSCC tumours in never-smokers https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17893858-Table3a 17893858.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 37.519992270756 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002272 Lymphoma Piccaluga07 185genes 125 Homo sapiens Table 2s. Genes differentially expressed in HLA-DR+ vs. HLA-DR- non-neoplastic T-lymphocytes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17304354-Table2s 17304354.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 79.5767617818854 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002273 Lymphoma Piccaluga07 70genes 50 Homo sapiens Table 3s. Genes differentially expressed in CD4+ vs. CD8+ non-neoplastic T-lymphocytes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17304354-Table3s 17304354.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 140.621886474414 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002274 Lymphoma Piccaluga07 64genes 54 Homo sapiens Table 5s. Genes over-expressed in PTCL/U vs. normal T-lymphocytes (corresponding to CD4+ CD8+ and HLA-DR+ elements) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17304354-Table5s 17304354.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 213.335479811773 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003447 Viral Schlecht07 85genes 66 Homo sapiens Table 3b. List of named genes that are differentially expressed (with lower expression) genes in HPV16+ and HPV16? primary HNSCC tumours in never-smokers https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17893858-Table3b 17893858.0 Viral PAGER curation team PAGER-contact@googlegroups.com CURRENT 27.5221806704704 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001499 Leukemia Sun07 407genes 326 Homo sapiens Supplementary Table 2a.Differentially expressed genes in M4Eo compared with M4 from the cDNA microarray that has significant p values at an fdr of 0.001 https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17571080-SuppTable2a 17571080.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 49.5939341917852 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001500 Leukemia Sun07 283genes 233 Homo sapiens Supplementary Table 2b. Differentially expressed genes in M4Eo compared with M4 from the Pathway microarray with p values https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17571080-SuppTable2b 17571080.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 436.733893075828 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001501 Leukemia Sun07 90genes 70 Homo sapiens Supplementary Table 2c. Differentially expressed genes that were present in both the cDNA and Pathway microarrays https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17571080-SuppTable2c 17571080.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 244.914720645101 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002278 Lymphoma Jaye07 genes 76 Homo sapiens Supplementary Table 1. Genes correlated with MTA3 expression https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17573669-SuppTable1 17573669.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 3.12519846461891 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002660 Prostate Verona07 41genes 35 Homo sapiens Table 1. TGF?-up-regulated PrSC genes involved in tissue remodeling https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17575140-Table1 17575140.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 178.32143322126 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001502 Leukemia Mullighan07 444genes 356 Homo sapiens Supplementary Table 2. 444 U133A probe sets differentially expressed between NPM1-mutant and all NPM1-wild-type pediatric AML cases https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17597811-SuppTable2 17597811.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 18.5908213314009 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001503 Leukemia Mullighan07 237genes 189 Homo sapiens Supplementary Table 3. 237 differentially expressed probe sets for NPM1-mutant v NPM1 wild type AML with normal/miscellaneous karyotype https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17597811-SuppTable3 17597811.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 14.7177243469625 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001504 Leukemia Mullighan07 744genes 571 Homo sapiens Supplementary Table 5. 744 U133A probe sets differentially expressed between MLL-rearranged and MLL-wild type pediatric AML cases https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17597811-SuppTable5 17597811.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 15.3914834745649 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001505 Leukemia Mullighan07 838genes 651 Homo sapiens Supplementary Table 6. 838 U133A probe sets differentially expressed between MLL-rearranged and MLL-wild type NPM1-wild type pediatric AML cases https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17597811-SuppTable6 17597811.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 19.6775054071443 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001506 Leukemia Mullighan07 566genes 452 Homo sapiens Supplementary Table 7. 566 U133A probe sets differentially expressed between NPM1-mutated and NPM1-wild type MLL-wild type pediatric AML cases https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17597811-SuppTable7 17597811.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 17.4616379164686 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001507 Leukemia Mullighan07 91genes 68 Homo sapiens Supplementary Table 9. 91 differentially expressed probe sets between NPM1-mutated and MLL-rearranged pediatric AML cases https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17597811-SuppTable9 17597811.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 7.90895683315995 N 1.0 13-AUG-20 GeneSigDB G 2942
WAG001017 hemoglobins chaperone 11 Homo sapiens The function of hemoglobin in oxygen transport by red blood cells requires precise assembly of a tetramer of two beta-subunits and two alpha-units. If too many beta-subunits are present, then all tetramers of beta-subunits are formed that bind oxygen but do not release it when needed. When alpha-subunits are in excess they form precipitates with oxidized heme that damage red blood cells. Red blood cells require a precise coregulation of alpha and beta subunit expression to maintain the proper ratio of the subunits and normal red blood cell function. Generally red blood cells express slightly more alpha than beta-subunits to avoid forming unproductive beta-tetramers (HbH). The slight excess of alpha units are blocked from precipitation by a molecular chaperone, AHSP, alpha-hemoglobin stabilizing protein. Expression of the AHSP gene is coorditely activated with the globin genes and heme biosynthesis genes by the GATA-1 gene involved in erythrocyte differentiation. AHSP blocks precipitation of alpha-units, and promotes the formation of normal productive alpha-beta tetramers (HbA). People with mutation or deletion of the beta-subunit gene have Beta-thalassemias resulting from an over-abundance of alpha subunits and their precipitation. The severity of the phenotype may depend on the AHSP genotype of these individuals and elevating AHSP levels through gene therapy may provide a treatment strategy for beta-thalassemia. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ahspPathway PAGER curation team PAGER-contact@googlegroups.com 1070.11535634177 1.0 13-AUG-20 BioCarta P 252
WAG001018 pten dependent cell cycle arrest and apoptosis 14 Homo sapiens PTEN is a tumor suppressor gene. Recombint PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of phosphatidylinositol 3 -kise. Many of the cancer-related mutations have been mapped to the phosphatase catalytic domain, it has been suggested that the phosphatase activity of PTEN is required for its tumor suppressor function. The activation of PKB/AKT is regulated in a complex manner via phosphorylation of AKT on Thr308 and Ser473 by PDK1 and ILK(integrin-linked kise) respectively. Ictivation of PTEN will constitutively activate PKB/AKT pathway. In addition to its role in regulating the PI 3-K/AKT cell survival pathway, PTEN also inhibits growth factor-induced Shc phosphorylation and suppresses the mitogen-activated protein (MAP) kise sigling pathway. PTEN also interact with FAK, a key molecule implicated in integrin sigling pathways, and it directly dephosphorylates tyrosine-phosphorylated FAK. PTEN down-regulation of p130CAS through FAK results in inhibition of cell migration and spreading. https://cgap.nci.nih.gov/Pathways/BioCarta/h_ptenPathway PAGER curation team PAGER-contact@googlegroups.com 2173.73063143277 1.0 13-AUG-20 BioCarta P 252
WAG001019 fibrinolysis pathway 14 Homo sapiens Clot formation and fibrinolysis is a balance of plasmin activation/inhibition and thrombin-thrombomodulin activity that regulates fibrin polymer formation and degradation. Active thrombin is produced by the cleavage of prothrombin in the https://cgap.nci.nih.gov/Pathways/BioCarta/h_fibrinolysisPathway PAGER curation team PAGER-contact@googlegroups.com 1523.53136955788 1.0 13-AUG-20 BioCarta P 252
FEX002876 StemCell Skottman06 91genes 67 Homo sapiens Table 5. Genes specifically expressed in HS237 hESCs cultured in serum-containing medium and with greater than twofold level compared with signal level in hESCs cultured in SR medium https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16100004-Table5 16100004.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 14.7586960678692 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002877 StemCell Skottman06 14genes 7 Homo sapiens Table 6. Genes specifically expressed in HS237 hESCs cultured in SR medium and with greater than twofold level compared with signal level in hESCs cultured in serum-containing medium https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16100004-Table6 16100004.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001854 Lung Coxon05 31genes 23 Homo sapiens Table 1. Differentially expressed transcripts in Mect1-Maml2 expressor clones compared with nonexpressor cell clones with https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16103063-Table1 16103063.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 5.89636688505063 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000021 Bladder MyersIrvin05 18genes 14 Homo sapiens Table 1. Genes that are up-regulated in cells expressing BLCA-4 compared with vector only controls https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16103064-Table1 16103064.0 Bladder PAGER curation team PAGER-contact@googlegroups.com CURRENT 41.3258809701622 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000022 Bladder MyersIrvin05 13genes 11 Homo sapiens Table 2. Genes that are down-regulated in cells expressing BLCA-4 compared with vector only controls https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16103064-Table2 16103064.0 Bladder PAGER curation team PAGER-contact@googlegroups.com CURRENT 29.9709724238026 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000023 Bladder Titus05 40genes 32 Homo sapiens Table 1. Gene expression differences found with Affymetrix HG-U133A GeneChip array analysis of pcDNA- and RhoGDI2-transfected metastatic human bladder cancer cell lines https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16103083-Table1 16103083.0 Bladder PAGER curation team PAGER-contact@googlegroups.com CURRENT 37.9208182905008 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001378 Leukemia Verhaak05 50genes 46 Homo sapiens Table 3. NPM1 mutation-associated gene expression in 275 patients with de novo AML https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16109776-Table3 16109776.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 125.549665672972 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001379 Leukemia Verhaak05 568genes 403 Homo sapiens Table S1. The 569 most significantly differentially expressed probe sets between AML cases https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16109776-TableS1 16109776.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 94.6149199250863 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000372 Breast Rouzier05 298genes 4classes 272 Homo sapiens Supplementary Table S1. Genes that characterize each of the 4 molecular classes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16115903-TableS1 16115903.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 21.5200744685887 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002437 Ovarian Okamoto05 44genes 34 Homo sapiens Table 2. Permutation analyses of 17 genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16115948-Table2 16115948.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 73.9107256188555 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002878 StemCell Chow06 57genes 55 Homo sapiens Table 1. Summary of genes differentially expressed in C666-1 RASSF1A-transfected clones https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16116475-Table1 16116475.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 24.5898161322518 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001380 Leukemia Bradbury05 23genes AssociatedProteinsPMBC 20 Homo sapiens Table S1 Expression of deacetylases and associated proteins in peripheral blood mononuclear cells (PBMC) from four normal donors measured by RTQ-PCR https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16121216-TableS1 16121216.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 3370.91529643207 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003036 StemCell Greco07 50genes MSCsandESCs 42 Homo sapiens Table 3. Top-ranked genes targeted by OCT4 in human MSCs and human ESCs. Data represent the 50 highest-ranked genes with known functions that were enriched with anti-OCT4. Chromatin was analyzed by chromatin immunoprecipitation-DNA selection and ligation; n=3. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17761754-Table3 17761754.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 10.0820446271443 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001240 Kidney Doghman07 98genes 64 Homo sapiens Supplementary Table I. Transcripts significantly regulated in H295R cells upon SF-1 overexpression. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17761949-TableS1 17761949.0 Kidney PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.96605249833948 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000538 Breast Watson07 67genes 62 Homo sapiens 67 unique transcripts overrepresented in EpCAM-selected samples at a level equal to or greater than that of the EpCAM antigen (TACSTD1) itself https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17785550-SuppTableS2 17785550.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 15.6333024964577 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002288 Lymphoma Uyttebroeck07 52genes 28 Homo sapiens Table II. Chromosomal regions discriminating T-ALL from T-LBL by CESH analysis linked with differentially expressed genes reported in the literature. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17786710-Table2 17786710.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 21.2888969465101 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001516 Leukemia Achiron07 55genes 49 Homo sapiens Table 2 Apoptosis-related genes operating in acute MS relapse https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17804543-Table2 17804543.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 344.863747805979 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000539 Breast Deeb07 61genesHumanGeneListHumanGeneList 59 Homo sapiens 61 genes significantly associated with overall survival (P https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17804718-HumanGeneList 17804718.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 15792.6668918598 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000984 EmbryonicStemCell Soh07 22genes 21 Homo sapiens Table 2. Selected list of human membrane receptors expressed in hESCs and hEBs arranged in descending order of signal intensity ratio of ESC/EB (Illumina platform). Only those genes with median signal intensities 10 in ESC were retained in this list. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17823238-Table2 17823238.0 Embryonic Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 13.5137138621201 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001620 Leukemia Gross09 279genes 248 Homo sapiens Supplemental Table S1. Comparison of Gene Expression Profiles in Parental IM-R and PD-R K562 Cells; 281 genes corresponding to 1% of the total set of genes present on the biochip were differentially expressed between parental and IM-R or PD-R https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19567819-SuppTable1 19567819.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 40.0382276451189 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000719 Breast Marella09 11genes GenesInvolvedBreastCancer 10 Homo sapiens Table 1. Highly up-regulated and down-regulated genes in MCF10CA1a involved in breast cancer https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19584277-Table1 19584277.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 40.0653120464441 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000720 Breast Marella09 30genes 27 Homo sapiens Table 2. Selected down-regulated genes in MCF10CA1a coding for functionally relevant proteins https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19584277-Table2 19584277.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 590.33632233483 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002347 Lymphoma Gentles09 780genes 540 Homo sapiens Table S6. Genes that are repressed in nave memory cord blood cells relative to centroblasts and centrocytes in the dataset of Basso et al. (Nature Genet 2005) (XLS 176 KB) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19636063-TableS6 19636063.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 1887.98523061276 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001510 Leukemia Lilljebjorn07 10genes 8 Homo sapiens Supplementary Table 1 The top ten probe sets within the minimally gained Xq region differing between ETV6/RUNX1-positive and other ALLs in the data set of Ross et al https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17690704-SuppTable1 17690704.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 126.426080635652 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001511 Leukemia Deaglio07 15genes 13 Homo sapiens Table 2. Differentially expressed genes of known function in the \migration\ https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17699742-Table2 17699742.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 6.16998950682057 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002556 Pancreas Nakamura07 1222genes 799 Homo sapiens Supplementary Table 1. A different level of expression for 1222 genes https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17699763-SuppTable1 17699763.0 Pancreas PAGER curation team PAGER-contact@googlegroups.com CURRENT 17.2228746045309 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002557 Pancreas Nakamura07 43genes 28 Homo sapiens Table 2. Top 20 up-regulated genes in peripheral zone and central zone of human pancreatic cancer growing in the pancreas of nude mice https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17699763-Table2 17699763.0 Pancreas PAGER curation team PAGER-contact@googlegroups.com CURRENT 21.7537746934589 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003028 StemCell Filippov07 15genes 14 Homo sapiens Table 1a. List of genes up-regulated in U2OSE6AS cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17699766-Table1a 17699766.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 39.4926719278467 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003029 StemCell Filippov07 23genes 13 Homo sapiens Table 1b. List of genes down-regulated in U2OSE6AS cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17699766-Table1b 17699766.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 3.47746650426309 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001905 Lung Johnson07 1334genes 838 Homo sapiens Supplemental Table 1: Genes that show altered expression in HepG2 cells in the presence of exogenously added let-7 https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17699775-SuppTable1 17699775.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 570.894058967238 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001907 Lung Johnson07 46genes 29 Homo sapiens Table 1. Cell cycle cell division and cell proliferation genes that respond to excess let-7 https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17699775-Table1 17699775.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 2439.81691007329 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001908 Lung Joo07 54genes 54 Homo sapiens Table 1. A partial list of genes induced and repressed in H460 cells after FOH treatment https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17699800-Table1 17699800.0 Lung PAGER curation team PAGER-contact@googlegroups.com CURRENT 549.08380200064 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002301 Lymphoma Staege08 50genes DownRegulated HodgkinlymphvNorm 39 Homo sapiens Figure 1a. Gene set enrichment analysis (GSEA) of Hodgkin https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18400362-Figure1b 18400362.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002303 Lymphoma Staege08 35genes 17 Homo sapiens Figure 2b. Examples of Hodgkin https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18400362-Figure2b 18400362.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 438.635877538857 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003172 StemCell Chang10 30genes 28 Homo sapiens Supplementary Table 2. List of genes commonly down-regulated in at least two resistant cell lines and re-activated by 5-Aza-dC https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=20215521-SuppTable2 20215521.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 6.90684508492023 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002335 Lymphoma Staub09 113genes 96 Homo sapiens Supplementary Table 2 WIPF1 correlation and survival/relapse association for 112genes of the WIPF1 module and WIPF1 itself https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19399471-SuppTable2 19399471.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.333807829181495 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002336 Lymphoma Staub09 39genes 33 Homo sapiens Table 1 Summary of WIPF1 correlation and survival/relapse association for 38 core genes of the WIPF1 module and WIPF1 itself https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19399471-Table1 19399471.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002337 Lymphoma Compagno09 genes 31 Homo sapiens Table S2. List of NF-kB related genes analyzed https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19412164-TableS2 19412164.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 4704.3543061459 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001614 Leukemia Haferlach09 500genes 300 Homo sapiens Table S1. Top 500 differentially expressed probe sets https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19429869-TableS1 19429869.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.59732735010158 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002498 Ovarian Murph09 45genes LPAinOVCAR3 37 Homo sapiens Table 1. Gene expression microarray results showing genes comprising the statistically-significant 39-gene LPA transcriptome signature in OVCAR-3. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19440550-table1 19440550.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 39.7872394324897 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001615 Leukemia Payton09 37genes 34 Homo sapiens Table 3 M3-specific signature?s most dysregulated genes: comparison of microarray and nCounter fold changes and nCounter average signal and qRT-PCR validation https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19451695-Table3 19451695.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 104.508338270637 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001616 Leukemia Porpaczy09 7genes 7 Homo sapiens Table 4 Validation by real-time PCR: genes associated with trisomy 12 and P-values https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19453646-Table4 19453646.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003076 StemCell Tondreau08 58genes 51 Homo sapiens Table 2a: List of genes detected by microarray analysis and modification of their expression after neurogenic differentiation (undifferentiated versus differentiated MSC) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18405367-Table2a 18405367.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 6.23189379407163 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003077 StemCell Tondreau08 52genes 40 Homo sapiens Table 2b: List of genes detected by microarray analysis and modification of their expression after neurogenic differentiation (undifferentiated versus differentiated MSC) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18405367-Table2b 18405367.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 78.1925049950421 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000708 Breast Tan07 5genes 5 Homo sapiens Table 1. Information on the 5 selected genes; all 5 genes overlap with the 32-gene signature identified by PAM (Thomassen et al. 2006a) and 2 of the 5 genes overlap with the 70-gene signature from van?t Veer et al. (2002) in their studies on breast cancer metastases https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19455244-Table1 19455244.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 23.9931740614334 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002338 Lymphoma Germinal07 18genes 16 Homo sapiens Table S10. Gene expression values of the main regulatory network distinguishing ABC and GCB https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19455257-TableS10 19455257.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 153.917678745727 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002339 Lymphoma Germinal07 77genes 42 Homo sapiens Table S8. Cell cycle gene set that best distinguishes ABC and GCB subgroup. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19455257-TableS8 19455257.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 28.2591704349752 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002340 Lymphoma Germinal07 44genes 42 Homo sapiens Table S9. The cell cycle genes which were chosen to distinguish the ABC and the GCB group. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19455257-TableS9 19455257.0 Lymphoma PAGER curation team PAGER-contact@googlegroups.com CURRENT 28.2591704349752 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002691 Prostate Zhang09 84genes 79 Homo sapiens Table 2 Ontological sorting of some differentially expressed genes in PC3-NKX3.1 (the NKX3.1 eukaryotic expression plasmid) and PC3-pcDNA3.1 (control) cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19462257-Table2 19462257.0 Prostate PAGER curation team PAGER-contact@googlegroups.com CURRENT 73.5865411586956 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000118 BoneMarrow Mahtouk07 41genes 31 Homo sapiens Table 1. SAM-defined overexpressed genes in HMCLs expressing HPSE https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17339423-Table1 17339423.0 Bone Marrow PAGER curation team PAGER-contact@googlegroups.com CURRENT 5.57100907061458 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001445 Leukemia Gebhard06 131genes 101 Homo sapiens Table 1. Hypermethylated gene fragments in myeloid leukemia cell lines https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=16778185-Table1 16778185.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 2.71444573901836 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002496 Ovarian Denkert09 300genes 267 Homo sapiens Supplementary Table 2. The 300-gene ovarian prognostic index (OPI) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19294737-SuppTable2 19294737.0 Ovarian PAGER curation team PAGER-contact@googlegroups.com CURRENT 18.2733953930453 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001613 Leukemia Yan09 13genes 13 Homo sapiens Table2. Up- or downregulated more than twofold genes in K562/A02 than in K562 cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=19302234-Table2 19302234.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 181.076000975906 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000518 Breast Creighton07 81genes ERnegHormoneIndependent EGFR 77 Homo sapiens SuppTable 3. Genes associated with hormone independence in both breast and prostate cancer are enriched for transcriptional targets of the EGFR signaling pathways. Excel worksheets with the expression data that was presented as heat maps in Figure 4 https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17598908-SuppTable3 17598908.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 18.7149617378808 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000519 Breast Creighton07 51genes ERnegHormoneIndependent up 50 Homo sapiens Table 1: Genes associated with hormone independence in breast cancer share significant overlap with genes associated with hormone independence in prostate cancer. Genes with elevated mRNA levels in common signature of hormone independence (Figure 1) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17598908-Table1 17598908.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 30.878771977049 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000520 Breast Creighton07 30genes ERnegHormoneIndependent down 27 Homo sapiens Table 2: Genes associated with hormone independence in breast cancer share significant overlap with genes associated with hormone independence in prostate cancer.Genes with diminished mRNA levels in common signature of hormone independence (Figure 2) https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17598908-Table2 17598908.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 8.09501712793098 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000521 Breast Lien07 213genes 171 Homo sapiens Supplementary Table 1 List of 213 probes representing 87 MCB- over-expressed genes and 121DCB-over-expressed genes as determined by Statistical Analysis of Microarrays (SAM) analysis with a false-discovery discovery rate up to 0.01. https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17603561-STable1 17603561.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 11.0852184998072 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX001508 Leukemia Rodriguez07 50genes 44 Homo sapiens Supplementary Table 3: Genes associated with Treatment-Free Survival https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17611561-SuppTable3 17611561.0 Leukemia PAGER curation team PAGER-contact@googlegroups.com CURRENT 266.390866575022 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003013 StemCell Nilsson07 55genes 54 Homo sapiens Table 3. Differentially expressed genes in 5q? versus normal CD34+CD38?Thy-1+ cells https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17616640-Table3 17616640.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 35.8188509576194 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX003063 StemCell Oh08 58genes 44 Homo sapiens Table 2 Differentially expressed genes in chronic GVHD patients https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=18332912-Table2 18332912.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.749139818579919 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002980 StemCell Ehrchen07 23genes 20 Homo sapiens Table 1. Genes up-regulated by GC treatment https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17018861-Table1 17018861.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 58.5213395763605 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002981 StemCell Ehrchen07 20genes 19 Homo sapiens Table 2. Genes down-regulated by GC treatment https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17018861-Table2 17018861.0 Stem Cell PAGER curation team PAGER-contact@googlegroups.com CURRENT 246.097333340975 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX000505 Breast Klein07 63genes human Mouse 62 Homo sapiens Table I. The 63 Genes Differentially Expressed in Human and Mouse Breast Tumors https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17410534-Table1 17410534.0 Breast PAGER curation team PAGER-contact@googlegroups.com CURRENT 754.391368196135 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002554 pancreas Kim07 34genes 31 Homo sapiens TABLE 2. Overexpressed Genes in pancreas Cancer With Lymph Node Metastasis https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17414055-Table2 17414055.0 Pancreas PAGER curation team PAGER-contact@googlegroups.com CURRENT 0.0 N 1.0 13-AUG-20 GeneSigDB G 2942
FEX002555 pancreas Kim07 59genes 47 Homo sapiens TABLE 3. Underexpressed Genes in pancreas Cancer With Lymph Node Metastasis https://www.genesigdb.org/genesigdb/signaturedetail.jsp?signatureId=17414055-Table3 17414055.0 Pancreas PAGER curation team PAGER-co